CN105699335A - Multifunctional SPR (surface plasmon resonance) detector - Google Patents
Multifunctional SPR (surface plasmon resonance) detector Download PDFInfo
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- CN105699335A CN105699335A CN201610228168.7A CN201610228168A CN105699335A CN 105699335 A CN105699335 A CN 105699335A CN 201610228168 A CN201610228168 A CN 201610228168A CN 105699335 A CN105699335 A CN 105699335A
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/066—Modifiable path; multiple paths in one sample
- G01N2201/0664—Using two ways, i.e. two devices in same path in one sample
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Abstract
The invention relates to a multifunctional SPR (surface plasmon resonance) detector. The multifunctional SPR detector comprises an incidence system, a rotating system and a detecting system, which are sequentially connected. Incidence light emitted by the incidence system reaches the detecting system at last by way of the rotating system. The multifunctional SPR detector also comprises an angle calibrating system used for calibrating incidence angle of the incidence light. The angle calibrating system is connected with the rotating system and the detecting system respectively. The multifunctional SPR detector can modulate angle and wavelength. When the detector works in an angle modulation mode, an incidence light source can be conveniently replaced, stability and convenience in measurement are upgraded. When the detector works in a wavelength modulation mode, a series of wavelength resonance spectrums corresponding to difference incidence angles can be obtained.
Description
Technical field
The present invention relates to photoelectric detection technology field, more particularly, to a kind of multi-functional SPR detector。
Background technology
Based on the detection technique of surface plasma resonance (SurfacePlasmonResonance, SPR) effect, its topmost application is the dielectric constant of detection medium。Dielectric constant is one of medium physical parameter most basic, most important。The often change such as through the dielectric permittivity that is associated such as react to each other between the component of material, material reflects。Since the eighties in last century, the detection technique based on SPR effect develops very swift and violent, and this technology has been widely used in the fields such as physics, biology, chemistry, environmental protection, medical science at present。In recent years, people do a lot of work in the exploitation optimizing design and instrumentation of SPR detector structure。At present, the research work of this respect is still hot subject。
SPR detector includes angle modulation type, many employing monochromatic light are as light source, automatically controlled turntable pointwise is adopted to carry out mechanical scanning, utilize photodetector that reflective light intensity is detected, by analyzing the position of the resonant angle that intensity minimum point is corresponding in reflectance spectrum, realizing the measurement of testing medium refractive index, single angle scanning can only obtain a spectral line。The accuracy of data owing to angle modulation type SPR detector cannot be carried out wavelength-modulated, therefore measurement result cannot be compared with wavelength-modulated measurement result easily in identical device, thus cannot be ensured well。
Summary of the invention
In order to overcome above the deficiencies in the prior art, the present invention provides a kind of multi-functional SPR detector being capable of angle and wavelength-modulated。
For solving prior art problem, the technical solution used in the present invention is:
A kind of multi-functional SPR detector, including the incidence system being sequentially connected with, rotation system and detection system, the incident illumination that described incidence system sends eventually arrives at detection system after rotation system;Described multi-functional SPR detector also includes the angle calibration system for the incident angle of incident illumination is demarcated, and described angle calibration system is connected with rotation system and detection system respectively。Due to the fact that and incidence system, rotation system and detection system are set, when incidence system adopts monochromater, under the cooperation of rotation system, it is possible to obtain normalized SPR angle modulation spectral line;Incidence system use wideband light source time, under the cooperation of rotation system, it is possible to obtain a series of normalized SPR wavelength-modulated spectral line, thus realizing angle and wavelength-modulated。
Described incidence system includes wideband light source, laser diode module, the first fiber coupling lens, the second fiber coupling lens, fiber coupler, parabolic reflector formula collimator, polarizing prism, adjustable diaphragm, unpolarized Amici prism and the first runner, and described unpolarized Amici prism is arranged on the first runner;
When carrying out wavelength-modulated, the incident illumination that wideband light source is launched passes sequentially through the second fiber coupling lens, fiber coupler, parabolic reflector formula collimator, polarizing prism, adjustable diaphragm and unpolarized Amici prism and injects rotation system;When carrying out angle modulation or angle calibration, the incident illumination that laser diode module is launched passes sequentially through the first fiber coupling lens, fiber coupler, parabolic reflector formula collimator, polarizing prism, adjustable diaphragm and unpolarized Amici prism and injects rotation system。
Further, described incidence system is additionally provided with the first electronic control translation stage, described parabolic reflector formula collimator, polarizing prism, adjustable diaphragm and the first runner adopt cage coaxial construction to be arranged on the first electronic control translation stage, and the mechanical stability of device is greatly improved, and easy to adjust fast。
Further, the interface that described parabolic reflector formula collimator docks with fiber coupler adopts SMA, FC/PC or FC/APC optical fiber input interface。
Described rotation system includes automatically controlled turntable and the rhombic prism being arranged on automatically controlled turntable, described rhombic prism one side is provided with the film system exciting SPR effect, the incident ray entering rotation system occurs to launch and injection after refraction inside rhombic prism, enters detection system。
Described detection system includes the second electronic control translation stage, reflecting mirror, the second runner, the 3rd fiber coupling lens and fiber spectrometer, and described reflecting mirror is arranged on the second runner, and described second runner and the 3rd fiber coupling lens are arranged on the second electronic control translation stage;The incident illumination of entrance detection system exposes to after passing sequentially through reflecting mirror and the 3rd fiber coupling lens and reaches fiber spectrometer, and described fiber spectrometer is connected with background computer。
Further, described detection system also includes the first achromat, the second achromat, the 3rd achromat, the first photodetector, the second photodetector, the 3rd photodetector and data collecting card;The part emergent light of incidence system exposes to the first photodetector by the first achromat, the part emergent light of rotation system exposes to the second photodetector by the second achromat, and the part emergent light of detection system exposes to the 3rd photodetector by the 3rd achromat;Described first photodetector, the second photodetector and the 3rd photodetector are connected with data collecting card respectively, and described data collecting card is connected with background computer。
Described multi-functional SPR detector is additionally provided with the stepper motor driver for driving the first electronic control translation stage, the second electronic control translation stage and automatically controlled turntable to be operated, and described stepper motor driver is connected with background computer。
Compared with prior art, the invention has the beneficial effects as follows:
The present invention has redesigned structure and light path, it is achieved that a SPR detector can be not only used for angular modulation system, can be used for again wavelength-modulated mode, adopts cage coaxial construction can improve the mechanical stability of device simultaneously;When working with angular modulation system, it is convenient to change incident light source, do not need to adjust whole incidence system, improve stability and the convenience of measurement;When working in wavelength-modulated mode, it is possible to obtain a series of wavelength harmonic lights corresponding to different incidence angles degree and compose, obtain corresponding to the angle modulation spectral line of each wavelength in spectrum simultaneously, it is possible to characterize the film system being used for exciting SPR effect conveniently and efficiently。
Accompanying drawing explanation
Fig. 1 is the structural representation of the embodiment of the present invention。
Detailed description of the invention
Below in conjunction with accompanying drawing the present invention will be further explained explanation。Accompanying drawing being merely cited for property explanation, it is impossible to be interpreted as limitation of the present invention;In order to the present embodiment is better described, some parts of accompanying drawing have omission, zoom in or out;To those skilled in the art, in accompanying drawing, some known features and explanation thereof are likely to omission and will be understood by。
As shown in Figure 1, a kind of multi-functional SPR detector, including incidence system, rotation system, detection system and angle calibration system, described incidence system includes wideband light source 5, laser diode module the 6, first fiber coupling lens the 7, second fiber coupling lens 8, fiber coupler 9, parabolic reflector formula collimator 10, polarizing prism 11, adjustable diaphragm 12, unpolarized Amici prism 13 and the first runner 14, and described unpolarized Amici prism 13 is arranged on the first runner 14;When carrying out wavelength-modulated, the incident illumination launched by wideband light source 5 exposes to fiber coupler 9 by the second fiber coupling lens 8, when carrying out angle modulation, the incident illumination that laser diode module 6 is launched exposes to fiber coupler 9 by the first fiber coupling lens 7;Then incident illumination injects rotation system after passing sequentially through parabolic reflector formula collimator 10, polarizing prism 11, adjustable diaphragm 12 and unpolarized Amici prism 13。Described incidence system is additionally provided with the first electronic control translation stage 15, and described parabolic reflector formula collimator 10, polarizing prism 11, adjustable diaphragm 12 and the first runner 14 adopt cage coaxial construction to be arranged on the first electronic control translation stage 15。The interface that described parabolic reflector formula collimator 10 docks with fiber coupler 9 adopts SMA fiber input interface。
Described rotation system includes automatically controlled turntable 16 and the rhombic prism 32 being arranged on automatically controlled turntable 16。In the present embodiment, described rhombic prism 32 has the first the 1, second side the 2, the 3rd, side side 3 and the 4th side 4, and the first side 1 is provided with the film system 17 exciting SPR effect。
Described detection system includes the second electronic control translation stage 28, reflecting mirror the 25, second runner the 26, the 3rd fiber coupling lens 27 and fiber spectrometer 29, described reflecting mirror 25 is arranged on the second runner 26, and described second runner 26 and the 3rd fiber coupling lens 27 are arranged on the second electronic control translation stage 28;The incident illumination of entrance detection system exposes to after passing sequentially through reflecting mirror 25 and the 3rd fiber coupling lens 27 and reaches fiber spectrometer 29, and described fiber spectrometer 29 is connected with background computer 31。
Described detection system also includes the first achromat the 19, second achromat the 20, the 3rd achromat the 22, first photodetector the 18, second photodetector the 21, the 3rd photodetector 23 and data collecting card 24,
The part emergent light of incidence system exposes to the first photodetector 18 by the first achromat 19, the part emergent light of rotation system exposes to the second photodetector 21 by the second achromat 20, and the part emergent light of detection system exposes to the 3rd photodetector 23 by the 3rd achromat 22;Described first photodetector the 18, second photodetector 21 and the 3rd photodetector 23 are connected with data collecting card 24 respectively, and described data collecting card 24 is connected with background computer 31。
Described multi-functional SPR detector is additionally provided with the stepper motor driver 30 for driving first electronic control translation stage the 15, second electronic control translation stage 28 and automatically controlled turntable 16 to be operated, and described stepper motor driver 30 is connected with background computer 31。
When carrying out angle modulation, after demarcating angle value, laser diode module launches the laser of a certain centre wavelength, by regulating two electronic control translation stages, make incident light beam strikes to the film system 17 exciting SPR effect, incident angle, detection system acquisition voltage data is scanned then as rotation system, by calculating the reflection of rhombic prism 32 surface and effect of dispersion, angle modulation spectral line R (θ) that the corresponding relation between incident angle θ and normalized reflectance R by rhombic prism 32 first side 1 is constituted may finally be obtained。
When carrying out wavelength-modulated, after demarcating angle value, select wideband light source 5, regulate the first electronic control translation stage 15 in incidence system, make incident illumination after refraction by prism, incide in the film system 17 exciting SPR effect, second electronic control translation stage 28 of detection system does corresponding translation, then as rotation system scanning incident angle progressively, fiber spectrometer 29 gathers spectrum, the a series of Wavelength modulation spectroscopies corresponding to angle of incidence values can be obtained, the reflection of rhombic prism 32 surface and effect of dispersion is revised by calculating, Wavelength modulation spectroscopy is divided by reference spectra, a series of normalized reflectance spectrum R (λ) of incident angle θ corresponding to rhombic prism 32 first side 1 may finally be obtained。
Obviously, the above embodiment of the present invention is only for clearly demonstrating example of the present invention, and is not the restriction to embodiments of the present invention。Can also make other changes in different forms on the basis of the above description, here without also cannot all of embodiment be given exhaustive。All any amendment, equivalent replacement and improvement etc. made within the spirit and principles in the present invention, should be included within the protection domain of the claims in the present invention。
Claims (8)
1. a multi-functional SPR detector, it is characterised in that including the incidence system, rotation system and the detection system that are sequentially connected with, the incident illumination that described incidence system sends eventually arrives at detection system after rotation system;Described multi-functional SPR detector also includes the angle calibration system for the incident angle of incident illumination is demarcated, and described angle calibration system is connected with rotation system and detection system respectively。
2. multi-functional SPR detector according to claim 1, it is characterized in that, described incidence system includes wideband light source (5), laser diode module (6), the first fiber coupling lens (7), the second fiber coupling lens (8), fiber coupler (9), parabolic reflector formula collimator (10), polarizing prism (11), adjustable diaphragm (12), unpolarized Amici prism (13) and the first runner (14), and described unpolarized Amici prism (13) is arranged on the first runner (14);
The incident illumination that wideband light source (5) is launched passes sequentially through the second fiber coupling lens (8), fiber coupler (9), parabolic reflector formula collimator (10), polarizing prism (11), adjustable diaphragm (12) and unpolarized Amici prism (13) and injects rotation system;The incident illumination that laser diode module (6) is launched passes sequentially through the first fiber coupling lens (7), fiber coupler (9), parabolic reflector formula collimator (10), polarizing prism (11), adjustable diaphragm (12) and unpolarized Amici prism (13) and injects rotation system。
3. multi-functional SPR detector according to claim 2, it is characterized in that, described incidence system is additionally provided with the first electronic control translation stage (15), and described parabolic reflector formula collimator (10), polarizing prism (11), adjustable diaphragm (12) and the first runner (14) adopt cage coaxial construction to be arranged on the first electronic control translation stage (15)。
4. multi-functional SPR detector according to claim 3, it is characterised in that the interface that described parabolic reflector formula collimator (10) is docked with fiber coupler (9) adopts SMA, FC/PC or FC/APC optical fiber input interface。
5. the multi-functional SPR detector according to any one of Claims 1-4, it is characterized in that, described rotation system includes automatically controlled turntable (16) and the rhombic prism (32) being arranged on automatically controlled turntable (16), and described rhombic prism (32) one side is provided with the film system (17) exciting SPR effect。
6. the multi-functional SPR detector according to any one of Claims 1-4, it is characterized in that, described detection system includes the second electronic control translation stage (28), reflecting mirror (25), the second runner (26), the 3rd fiber coupling lens (27) and fiber spectrometer (29), described reflecting mirror (25) is arranged on the second runner (26), and described second runner (26) and the 3rd fiber coupling lens (27) are arranged on the second electronic control translation stage (28);The incident illumination of entrance detection system exposes to after passing sequentially through reflecting mirror (25) and the 3rd fiber coupling lens (27) and reaches fiber spectrometer (29), and described fiber spectrometer (29) is connected with background computer (31)。
7. multi-functional SPR detector according to claim 6, it is characterized in that, described detection system also includes the first achromat (19), second achromat (20), 3rd achromat (22), first photodetector (18), second photodetector (21), 3rd photodetector (23) and data collecting card (24), the part emergent light of incidence system exposes to the first photodetector (18) by the first achromat (19), the part emergent light of rotation system exposes to the second photodetector (21) by the second achromat (20), the part emergent light of detection system exposes to the 3rd photodetector (23) by the 3rd achromat (22);Described first photodetector (18), the second photodetector (21) and the 3rd photodetector (23) are connected with data collecting card (24) respectively, and described data collecting card (24) is connected with background computer (31)。
8. multi-functional SPR detector according to claim 6, it is characterized in that, being additionally provided with the stepper motor driver (30) for driving the first electronic control translation stage (15), the second electronic control translation stage (28) and automatically controlled turntable (16) to be operated, described stepper motor driver (30) is connected with background computer (31)。
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Cited By (1)
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CN107843558A (en) * | 2017-09-21 | 2018-03-27 | 丁利 | A kind of prism-type surface plasma resonance spectrometer angle modulated mechanism |
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