CN105686892B - Infection by Schistosoma laboratory mice fixing device and experimental method - Google Patents
Infection by Schistosoma laboratory mice fixing device and experimental method Download PDFInfo
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- CN105686892B CN105686892B CN201410708210.6A CN201410708210A CN105686892B CN 105686892 B CN105686892 B CN 105686892B CN 201410708210 A CN201410708210 A CN 201410708210A CN 105686892 B CN105686892 B CN 105686892B
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- schistosoma
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Abstract
The invention discloses a kind of infection by Schistosoma laboratory mice fixing device and experimental method, including bottom plate, bottom plate upper surface has the working region for being used for placing mouse, the both sides of working region are provided with multiple holes, two holes in multiple holes are positioning hole, wherein it is equipped with elastic drawstring, the upper end of elastic drawstring is fixed on the limb arm of mouse, the other end is mutually fixed so that the limb arm of mouse is pressed on bottom plate through positioning hole and by locating part with bottom plate, is additionally provided with bottom plate for the fixture on bottom plate that mouse neck is fixed and clamped.The infection by Schistosoma laboratory mice fixture structure is simple, the four limbs and neck of the mouse of different volumes size can be fixed in experimentation, prevent from avoiding the staff that bites during mouse experiment while mouse from sustaining damage, the data in record mouse infection by Schistosoma experimentation in time can be realized simultaneously and data are timed with statistics, in order to the progress of subsequent experimental.
Description
Technical field
The present invention relates to a kind of zoopery apparatus, and in particular to a kind of infection by Schistosoma laboratory mice fixing device,
A kind of and mouse infection by Schistosoma experimental method.
Background technology
Mouse is a kind of conventional experimental animal of medical research, is to be formed according to the requirement directive breeding of scientific research, is
For the object and material of scientific experiment, it is mainly used in the study on reproduction of animal, is also widely used for nutrition, immune, cosmetics are surveyed
Examination etc., often needed in experimentation to mouse carry out oral cavity perfusion, be injected intraperitoneally, establish model, tail vein injection and
The operations such as blood sampling chemical examination, in the prior art, frequently with the method for single-handedly capturing mouse when carrying out these operations, due in Mice Body
A variety of viruses are carried, if bitten in free-hand crawl by mouse, the health of experimenter can be influenceed, even result in infectious disease
Break out.
The content of the invention
It is an object of the invention to provide a kind of infection by Schistosoma laboratory mice fixing device, its is simple in construction, can facilitate
The four limbs and neck to mouse be fixed, prevent that small damaged by rats hinders staff in experimentation.
To reach above-mentioned purpose, the technical solution adopted by the present invention is：
A kind of infection by Schistosoma laboratory mice fixing device includes bottom plate, and the bottom plate upper surface has small for placing
The working region of mouse, the both sides of the working region are provided with hole group of at least one row through the bottom plate upper and lower ends face,
Kong Zuzhong described in each column is provided with least two holes, has two holes respectively accordingly to use at least two holes described in per side
Elastic drawstring, the upper end of the elastic drawstring are equipped with the positioning hole of the fixed mouse two limb arms in side, the positioning hole
It is fixed on a limb arm for the mouse, the other end of the elastic drawstring through the positioning hole and passes through locating part and institute
Bottom plate is stated mutually to fix so that the limb arm of the mouse is pressed on the bottom plate；It is additionally provided with the bottom plate for by the neck of mouse
Portion is fixed and clamped the fixture on the bottom plate.
Preferably, the fixture can oscilaltion on the bottom plate, the fixture includes the pressure that middle part is arch
Plate, the pressing plate arch position have arcuate openings directed downwardly, the cushion of arch are provided with the opening, in described pressing plate
Multigroup shell fragment is provided between cushion, the fixture also includes the elasticity for being arranged on the pressing plate bow-shaped structural both sides lower surface
Element.
Preferably, the elastic drawstring is elastic rubber band, and its upper end is provided with the collar of collapsible size, the collar
It is set on the limb arm of mouse.
Preferably, the upper surface of described bottom plate is additionally provided with tally and timer for recording experiment information.
Preferably, it is provided with handle in the middle part of the bottom plate lower surface.
Preferably, it is provided with support feet on four angles of the bottom plate lower surface.
Preferably, the height of the support feet is not less than the height of the handle.
Preferably, the both sides of the bottom plate are respectively arranged with to deposit the drawer of experiment appliance and defective work.
Preferably, the disposable shield for preventing urine and dirt is provided with the working region of the bottom plate.
It is a further object of the present invention to provide a kind of mouse infection by Schistosoma experimental method.
To reach above-mentioned purpose, the technical solution adopted by the present invention is：
Using the experimental method of above-mentioned infection by Schistosoma mouse fixing, comprise the following steps：
（1）The four limbs of mouse are fixed and clamped on the bottom plate：When fixed, first mouse is faced upward and is placed on the bottom plate
Working region in, its four limb arms are pulled open to the both sides of its body, the elastic drawstring upper end is fixed on the one of mouse
It is on individual limb arm, the elastic drawstring other end is through the hole on the bottom plate and mutually solid with the bottom plate by the locating part
It is fixed, so as to which a limb arm for mouse be fixed and clamped on the bottom plate, the compression mode and this phase of its excess-three limb arm of mouse
Together, until the four limbs of mouse are all pressed on bottom plate；
（2）The neck of mouse is fixed and clamped on the bottom plate：When fixed, the fixture is arranged on to the neck of mouse
Portion, mouse neck is pressed abd fixed on the bottom plate after adjusting fixture height；
（3）Infection by Schistosoma laboratory operating procedures：Mouse is first recorded into mouse blood through belly skin infection blood fluke cercaria
Fluke infection situation, time recording experimental data and statistical experiment result.
Due to the utilization of above-mentioned technical proposal, the present invention has following advantages compared with prior art：It is simple in construction, small
Position when can easily be fixed, while fix to the four limbs and neck of mouse in mouse infection by Schistosoma experimentation can root
It is adjusted according to the mouse of different volumes size, prevents mouse from can avoid work of biting during mouse experiment while sustaining damage
Make personnel；The data in record mouse infection by Schistosoma experimentation in time can be also realized in addition and data are timed with system
Meter, in order to the progress of subsequent experimental.
Brief description of the drawings
Fig. 1 is the overall structure diagram of infection by Schistosoma laboratory mice fixing device of the present invention；
Fig. 2 is infection by Schistosoma laboratory mice fixing device right side structural representation of the present invention.
Embodiment
Technical scheme is further elaborated with specific embodiment below in conjunction with the accompanying drawings.
Referring to the infection by Schistosoma laboratory mice fixing device shown in Fig. 1 and Fig. 2, the infection by Schistosoma laboratory mice
Fixing device includes bottom plate 1, and the upper surface of bottom plate 1 is provided with working region, for placing mouse, is all provided with the both sides of working region
At least one row are equipped with through the hole group 2 of the upper and lower ends face of bottom plate 1, the quantity at least two of the mesopore of each column hole group 2, per side institute
There are the forelimb and hind leg that two holes correspond to mouse respectively at least two holes stated, the two holes are positioning hole 201, in the positioning
Elastic drawstring 3 is equipped with hole 201, the upper end of elastic drawstring 3 is fixed on a limb arm 12 for mouse, elastic drawstring 3 it is another
One end is through positioning hole 21 and by locating part 4 with the phase fixation of bottom plate 1 so that the limb arm 12 of mouse is pressed on bottom plate 1.For side
Just use, elastic drawstring 3 can use elastic rubber band, and the upper end of elastic rubber band is provided with the collar 301 of collapsible size, should
The collar 301 is enclosed on the limb arm of mouse, and the collar 301 can be fixed on the limb arm of mouse by tensing the other end of elastic rubber band
On.
Multiple row hole group and multiple holes are provided with bottom plate 1, to facilitate according to the mouse of different volumes size easily to adjust
The fixed position of whole mouse, it can play a part of preventing mouse from coming to harm while fixed mouse is realized.Elastic drawstring 3 is tied up
The tightness of tight mouse can be adjusted by locating part 4, further mouse can be avoided to come to harm, spacing for convenience of using
Part 4 can be retraction cord button or spring cord lock.
It is additionally provided with the upper surface of bottom plate 1 for mouse neck to be fixed and clamped the fixture 5 on bottom plate 1, during fixture 5 includes
Portion is the pressing plate 501 of arch, and the arch position of pressing plate 501 has opening directed downwardly, and be open the interior cushion 502 for setting arch, to prevent
Only crushing mouse makes its agitation struggle, and multigroup shell fragment 503 is set between pressing plate 501 and cushion 502, so as to realize to mouse neck
The regulation of tightness is fixed in portion.To be adapted to the fixation of the neck to the big mouselet of different volumes, in the bow-shaped structural of pressing plate 501
The lower surface of domain both sides is provided with flexible member 504, and flexible member 504 can use spring or rubber blanket, so that fixture 5 can
Oscilaltion.The both sides of pressing plate 501 are provided with the connecting hole through its upper and lower end face, when flexible member uses rubber blanket,
The connecting hole passes through the hole group 2 on the connecting hole and bottom plate 1 through the upper and lower end face of rubber blanket correspondence position, bolt 505 simultaneously
In hole fixture 5 is fixed on bottom plate 1.
For convenience, experiment information is recorded in time and periodically check simultaneously statistical experiment result, also set in the upper surface of bottom plate 1
There are tally 10 and timer 11.
For convenience of experimental implementation, the bottom plate 1 relative with placing mouse in infection by Schistosoma laboratory mice fixing device
Other end in the middle part of be provided with handle 6, carry out experimental implementation in order to clamp the fixing device with hand, it can in addition contain
Setting support feet 6 on four angles of one end end face of handle 6 is provided with bottom plate 1, the height of support feet 7 need to be high not less than handle 6
Degree, experimental implementation is carried out in order to which the infection by Schistosoma laboratory mice fixing device is placed on testing stand.
The both sides of bottom plate 1 are provided with drawer 8, place the experiments such as cotton swab, injection needle, marking pen in the drawer of side and use
Tool, the drawer of opposite side is interior to be can be used for placing some discarded articles in experimentation, and such setting can make experimental field whole
Realized while clean before using with using rear article separated, prevent bacterial virus cross-infection.
To avoid the excrement of mouse and urine pollution working region in experimentation, mouse is being placed on bottom plate 1
When in working region, disposable shield 9 is first laid in working region, the big I of shield 9 determines according to the size of mouse,
Shield 9 needs waterproof, and to prevent the pollutants such as urine from penetrating into the working region of bottom plate 1, shield 9 can use multilayer detachable
The structure being bonded together, one layer with tearing after dirty, it is convenient and swift.
Mouse infection by Schistosoma experimental method comprises the following steps：
（1）The four limbs of mouse are fixed and clamped on bottom plate：First mouse is faced upward and is placed on the workspace of the upper surface of bottom plate 1
In domain, its four limb arms 12 are pulled open to the both sides of its body, the collar 301 of the upper end of elastic drawstring 3 is enclosed on one of mouse
On limb arm 12, the other end of tensile elasticity drawstring 3, the collar 301 is tightened up and is fixed on the limb arm 12 of mouse, afterwards by elastic drawstring
3 other ends are fixed through the hole on bottom plate 1 and by locating part 4 and the phase of bottom plate 1, so as to which a limb arm 12 for mouse be pressed on
On bottom plate 1, the compression mode of its excess-three limb arm 12 of mouse is identical with this, until the four limbs of mouse are all pressed on bottom plate 1；
（2）The neck of mouse is fixed and clamped on the bottom plate：When fixed, the fixture 5 is arranged on to the neck of mouse
Portion, mouse neck is pressed abd fixed on bottom plate 1 after adjusting the height of fixture 5；
（3）Infection by Schistosoma laboratory operating procedures：Mouse is set then to be recorded through belly skin infection blood fluke cercaria first
Mouse infection by Schistosoma situation, and experimental data is recorded on tally 10 in time；Timer 11 is arranged to 20 minutes,
An experimental result was counted every 20 minutes.
So, can be easily to the small of different volumes size after using the infection by Schistosoma laboratory mice fixing device
Mouse is fixed, while the fixed position of mouse and tightness are adjustable, avoid mouse from being prevented while sustaining damage
Bite staff in experimentation.
The above embodiments merely illustrate the technical concept and features of the present invention, and its object is to allow person skilled in the art
Scholar can understand present disclosure and implement according to this, and it is not intended to limit the scope of the present invention.It is all according to the present invention
The equivalent change or modification that Spirit Essence is made, it should all be included within the scope of the present invention.
Claims (8)
- A kind of 1. infection by Schistosoma laboratory mice fixing device, it is characterised in that：Including bottom plate, the bottom plate upper surface has For placing the working region of mouse, the both sides of the working region are provided with least one row and run through the bottom plate upper and lower ends The hole group in face, Kong Zuzhong described in each column are provided with least two holes, there is two hole difference at least two holes described in per side To be correspondingly used for fixing the positioning hole of the mouse two limb arms in side, elastic drawstring, the elasticity are equipped with the positioning hole The upper end of drawstring is fixed on a limb arm for the mouse, and the other end of the elastic drawstring through the positioning hole and passes through Locating part is mutually fixed so that the limb arm of the mouse is pressed on the bottom plate with the bottom plate, and the elastic drawstring is elastic rubber Rubber band, its upper end are provided with the collar of collapsible size, and the collar is set on the limb arm of mouse；It is additionally provided with the bottom plate For the fixture that the neck of mouse is fixed and clamped on the bottom plate, the fixture can oscilaltion be located at the bottom plate On, the fixture includes the pressing plate that middle part is arch, and the pressing plate arch position has an arcuate openings directed downwardly, in the opening The cushion of arch is provided with, multigroup shell fragment is provided between described pressing plate and cushion, the fixture also includes being arranged on institute State the flexible member of pressing plate bow-shaped structural both sides lower surface.
- 2. infection by Schistosoma laboratory mice fixing device according to claim 1, it is characterised in that：Described bottom plate Upper surface is additionally provided with tally and timer for recording experiment information.
- 3. infection by Schistosoma laboratory mice fixing device according to claim 1, it is characterised in that：The bottom plate lower end Handle is provided with the middle part of face.
- 4. infection by Schistosoma laboratory mice fixing device according to claim 3, it is characterised in that：The bottom plate lower end Support feet is provided with four angles in face.
- 5. infection by Schistosoma laboratory mice fixing device according to claim 4, it is characterised in that：The support feet Highly it is not less than the height of the handle.
- 6. infection by Schistosoma laboratory mice fixing device according to claim 1, it is characterised in that：The two of the bottom plate Side is respectively arranged with to deposit the drawer of experiment appliance and defective work.
- 7. infection by Schistosoma laboratory mice fixing device according to claim 1, it is characterised in that：The institute of the bottom plate State the disposable shield being provided with working region for preventing urine and dirt.
- 8. the experimental method of the infection by Schistosoma laboratory mice fixing device as described in any in claim 1 to 7 is used, its It is characterised by：Experimental method comprises the following steps：（1）The four limbs of mouse are fixed and clamped on the bottom plate：When fixed, first mouse is faced upward and is placed on the work of the bottom plate Make in region, its four limb arms are pulled open to the both sides of its body, the elastic drawstring upper end is fixed on to a limb for mouse On arm, the elastic drawstring other end is mutually fixed through the hole on the bottom plate and by the locating part and the bottom plate, So as to which a limb arm for mouse be fixed and clamped on the bottom plate, the compression mode of its excess-three limb arm of mouse is identical with this, Until the four limbs of mouse are all pressed on bottom plate；（2）The neck of mouse is fixed and clamped on the bottom plate：When fixed, the fixture is arranged on to the neck of mouse, adjusted Mouse neck is pressed abd fixed on the bottom plate after whole fixture height；（3）Infection by Schistosoma laboratory operating procedures：Mouse is first recorded into mouse blood fluke through belly skin infection blood fluke cercaria Infection conditions, time recording experimental data and statistical experiment result.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410708210.6A CN105686892B (en) | 2014-11-28 | 2014-11-28 | Infection by Schistosoma laboratory mice fixing device and experimental method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410708210.6A CN105686892B (en) | 2014-11-28 | 2014-11-28 | Infection by Schistosoma laboratory mice fixing device and experimental method |
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| Publication Number | Publication Date |
|---|---|
| CN105686892A CN105686892A (en) | 2016-06-22 |
| CN105686892B true CN105686892B (en) | 2018-04-03 |
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| CN201410708210.6A Active CN105686892B (en) | 2014-11-28 | 2014-11-28 | Infection by Schistosoma laboratory mice fixing device and experimental method |
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| KR102533678B1 (en) * | 2021-08-25 | 2023-05-17 | (주)플라스바이오 | Experimental animal restrainer applicable to various drug administration method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2334359Y (en) * | 1998-07-16 | 1999-08-25 | 山东医科大学 | Operation table for experiment animal sustained inhalation anesthesia |
| CN201692092U (en) * | 2010-03-29 | 2011-01-05 | 刘辉 | Mouse fixer |
| CN101984934A (en) * | 2010-12-16 | 2011-03-16 | 西安融慧专利产品开发咨询有限责任公司 | Big experimental animal fixer |
| CN202458771U (en) * | 2012-02-27 | 2012-10-03 | 河南农业大学 | Mouse experimental fixing device |
| CN102579152B (en) * | 2012-03-17 | 2014-10-22 | 江苏省血吸虫病防治研究所 | Semi-automatic mouse fixing apparatus for schistosome infection tests |
| CN202892142U (en) * | 2012-11-09 | 2013-04-24 | 绍兴市人民医院 | Experimental rat and mouse fixing apparatus assembly |
| CN203749638U (en) * | 2014-03-18 | 2014-08-06 | 苏州大学 | Caudal intravenous injection fixing device for mice |
| CN204274706U (en) * | 2014-11-28 | 2015-04-22 | 苏州大学 | Schistosomicide laboratory mice fixture |
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