CN105682708B - Driving assembly for medicine delivery device and the medicine delivery device including driving assembly - Google Patents

Driving assembly for medicine delivery device and the medicine delivery device including driving assembly Download PDF

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Publication number
CN105682708B
CN105682708B CN201480057182.4A CN201480057182A CN105682708B CN 105682708 B CN105682708 B CN 105682708B CN 201480057182 A CN201480057182 A CN 201480057182A CN 105682708 B CN105682708 B CN 105682708B
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CN
China
Prior art keywords
piston rod
driving assembly
locking component
dosage
assembly according
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CN201480057182.4A
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Chinese (zh)
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CN105682708A (en
Inventor
S·L·比尔顿
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Sanofi Aventis France
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Sanofi Aventis France
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/3157—Means providing feedback signals when administration is completed

Abstract

The driving assembly (180) for being used for medicine delivery device (101) is provided, which includes spring member (127), piston rod (102) and the piston rod nut (126) engaged with piston rod (102).Piston rod nut (126) is configured to rotate during dosage setting and move in the axial direction, wherein, when moving piston stem nut (126) during dosage setting, spring member (127) is pressed, and wherein, piston rod nut (126) is fixed in steering during dosage distribution.

Description

Driving assembly for medicine delivery device and the drug conveying including driving assembly Device
Technical field
This disclosure relates to a kind of driving assembly for medicine delivery device and the medicine delivery device including driving assembly. Specifically, which can make spring driven.As an example, medicine delivery device can be automatic injection Device specifically can be semi-automatic automatic injector.It can be with spring loaded component during dosage setting.
Medicine delivery device includes for example in file US 7,740,618B2,1 EP 804 858B1 and WO 2011/ 060786A1。
Summary of the invention
It is an object of the present invention to provide the driving assemblies for medicine delivery device with improved property.
A kind of driving assembly for medicine delivery device is provided, the driving assembly include spring member, piston rod and The piston rod nut engaged with piston rod.Piston rod nut is configured to rotate during dosage setting and move in the axial direction, Wherein, when the moving piston stem nut during dosage setting, spring member is pressed.The piston rod nut during dosage distribution It can be fixed in steering.Specifically, piston rod nut can be configured to during dosage setting relative to driving assembly Shell is rotated and is moved in the axial direction.During dosage distribution, piston rod nut can be fixed in steering relative to shell.
During dosage setting, spring member can be pressed by piston rod nut.During dosage setting, piston rod spiral shell Mother rotates around piston rod and moves in the axial direction relative to piston rod.Piston rod nut is in the axial direction during dosage setting The distance of movement determines the amount of the dosage conveyed during dosage distribution.Specifically, piston rod nut exists during dosage setting The distance that axis moves upwards determines the distance of the piston rod movement during dosage distribution.During dosage distribution, piston rod nut It can be fixed relative to piston rod.
Spring member can be such as disc spring.But any kind of spring can be used, such as spring washer or waveform Spring.Spring member may be used as energy storage member.Specifically, when spring member is pressed, energy be can store in spring In component.The energy can be discharged during dosage distributes for driving piston rod in distal direction.It is applied as a result, by user The power being added in medicine delivery device can keep low-level.Specifically, by being applied to piston rod nut during dosage distribution Reinforcing, spring member can cause piston rod to move upwards towards the side of device distal end.Specifically, spring member can cause The movement of piston rod nut and to dosage distribution during moving piston bar.
According to an embodiment, spring member is contacted with piston rod nut.Specifically, spring member can be with piston rod nut Proximal end face contact and the applied force on the proximal end face of piston rod nut so that piston rod nut is during dosage distributes to device Distal movement.Specifically, dosage distribution during, piston rod nut can move in the axial direction and without in steering Movement.During dosage setting, it can be suppressed by the movement in the axial direction of spring member bring piston rod nut.In agent During measurement disappears, the movement of the combination in the axial direction and steering of piston rod nut can be caused by spring member.Specifically, in agent During measurement disappears, the relaxation of spring member can permit.
Term " distal end " can describe the end of device or the part that its distribution end from device is nearest.Term " proximal end " can To describe the end or its farthest part in distribution end from device of device.Similarly, term " distal direction " can describe court To the direction at the distribution end of device, and term " proximal direction " can describe the direction at the distribution end far from device.
According to an embodiment, piston rod includes that at least one screw thread and piston rod nut can connect with piston rod thread It closes.
Piston rod can be configured to driving screw.Piston rod can be configured as at drug container (such as storage tube) In plug or piston on, cause from the container allocation drug.Bearing surface can be set in the distal end of piston rod, wherein bearing Face is configured to against plug or piston.Piston rod may include more than one screw thread, such as two screw threads.Piston rod it is another One screw thread can be configured to medicine delivery device that piston rod can be inhibited to move during dosage setting another Component engagement.
According to an embodiment, during the setting and distribution of dosage, piston rod can be fixed in steering relative to shell. As an example, piston rod may include at least one axial notch or at least one axial splines.At least one axial direction Groove or at least one axial splines can be configured to the shell fixed piston rod on turning to relative to driving assembly.This can To pass through at least one groove or spline and the corresponding spline of component fixed in steering relative to shell or connecing for groove It closes to realize.Alternatively, at least one groove or spline can spline corresponding with shell or groove engagements.
According to an embodiment, driving assembly includes the locking component with lock state, wherein locking component and piston rod It is threadedly engaged, and wherein, when locking component is in its lock state, the locking component inhibits the relaxation of spring member.
According to an embodiment, piston rod can move in the axial direction, but fixed in steering during dosage distribution, especially It is to be fixed relative to shell.The axial movement of piston rod can be realized by locking component from the release of its lock state.? During dosage setting.Piston rod can be fixed in the axial direction relative to shell.
During dosage setting, locking component may be at its lock state.During the setting and distribution of dosage, locking Component can be fixed in the axial direction relative to shell.For example, locking component may include against medicine delivery device component or The flange of shell.Locking component can be such as lock nut.
Due to the engagement during dosage setting with another component of medicine delivery device, locking component may be at locking Determine state.Another component can be fixed in steering relative to shell.When locking component is in its lock state, structure is locked The rotation of part is suppressed.Because locking component is engaged with piston rod thread, and piston rod is fixed in steering relative to shell, So the axial movement of piston rod is suppressed when the rotation of locking component is suppressed.The axial fortune of piston rod nut as a result, It is dynamic, and thus the relaxation of spring member can be suppressed.Specifically, the pure axial movement of piston rod nut can be pressed down System.But during dosage is cancelled, it can permit the relaxation of spring member.
According to an embodiment, when locking component is discharged from its lock state, locking component can make spring member relaxation.
During dosage distribution, the engagement of another component of locking component and medicine delivery device can be released, and And to which locking component can be discharged from its lock state.Specifically, when from its lock state discharge when, locking component relative to Shell can rotate freely.According to an embodiment, during dosage distribution, locking component can be configured to affect (overhaul) screw thread of piston rod, especially piston rod.Specifically, when it is discharged from lock state, locking component can be with It is rotated along piston rod.Thereby, it is possible to make piston rod in the axial direction towards the distal movement of device.Thus, it is possible to realize piston rod spiral shell Mother towards the distal end of device movement, and thus allow spring member relaxation.Thus, it is possible to realize point of drug dose Match.
According to an embodiment, when locking mechanism is discharged from its lock state, by means of spring member, piston rod can court To the distal movement of device.
According to an embodiment, driving assembly may include actuator, which is configured to convey and fill from drug It sets conveying drug dose and starts, wherein when actuator is activated, spring member can relax.It can be started by user and be caused Dynamic device.Actuator can be fixed in steering relative to shell.
According to an embodiment, when actuator is activated, locking component is released from its lock state.Specifically, when When actuator is not activated during dosage setting, locking component and actuator can be engaged.When actuator is activated, actuating Device and locking component can be detached from.As a result, locking component can rotate.When locking component is released from its lock state When, it can be realized the relaxation of spring member and the axial movement to realize piston rod.
According to an embodiment, driving assembly includes rotating member, wherein during dosage setting, piston rod nut is with rotation Turn the rotation of component and rotates.Rotating member can be sleeve.Piston rod nut can be fixed in steering, but can be in axial direction On relative to rotating member move.Rotating member can be rotated with setting dosage.When rotating member is rotated along dosage setting direction When, piston rod nut can be moved towards the proximal end of device.When rotating member, which cancels direction along dosage, to be rotated, piston rod nut It can be towards the distal movement of device.
According to an embodiment, driving assembly includes indicator, which is configured to the amount of instruction setting dosage.In agent Amount setting during, indicator can due to rotating member rotation and rotate.It specifically, can be proximally during dosage setting Rotation indicator.It, can be towards the distal end rotation indicator of device due to the rotation of rotating member during dosage is cancelled.Refer to Show that device can be digital sleeve.
According to another aspect of the present invention, a kind of medicine delivery device including driving assembly is provided.It can be as described above Constitute driving assembly.
Medicine delivery device can be injection device.Medicine delivery device can be variable dose device so that user can be with Select the size of dosage.Medicine delivery device can be configured for multi-dose application.Medicament can be conveyed by means of needle To user.Medicine delivery device can be pencil type apparatus.Medicine delivery device can be disposably.Term " disposable " means Medicament delivery device can cannot be reused after dosage from conveying device conveying.Medicine delivery device can be by It is configured to conveying liquid preparation.Medicament can be such as insulin.
Language " medicament " (medication) used herein preferably means containing at least one pharmaceutically active compound Pharmaceutical formulation,
Wherein in one embodiment, the pharmaceutically active compound have up to the molecular weight of 1500Da and/or Person is that peptide, protein, polysaccharide, vaccine, DNA, RNA, enzyme, antibody or its segment, hormone or oligonucleotides or above-mentioned pharmacy are living The mixture of property compound,
Wherein in a further embodiment, the pharmaceutically active compound for treat and/or prevent diabetes or with The related complication of diabetes, such as diabetic retinopathy (diabetic retinopathy), thromboembolic disorders (thromboembolism disorders) such as Deep venou or pulmonary thromboembolism, acute coronary syndrome (acute Coronary syndrome, ACS), it is angina pectoris, myocardial infarction, cancer, macular degeneration (macular degeneration), scorching Disease, hay fever, atherosclerosis and/or rheumatoid arthritis be it is useful,
Wherein in a further embodiment, the pharmaceutically active compound includes at least one for treatment and/or pre- The peptide of anti-diabetes or complication related with diabetes (such as diabetic retinopathy),
Wherein in a further embodiment, the pharmaceutically active compound includes at least one actrapid monotard or people's pancreas islet Plain analog or derivative, glucagon-like peptide (glucagon-like peptide, GLP-1) or its analog or derivative Object or Exendin -3 (exedin-3) or exendin-4 (exedin-4) or Exendin -3 or exendin The analog or derivative of peptide -4.
Insulin analog such as Gly (A21), Arg (B31), Arg (B32) actrapid monotard；Lys (B3), Glu (B29) people Insulin；Lys (B28), Pro (B29) actrapid monotard；Asp (B28) actrapid monotard；Actrapid monotard, wherein B28 proline It is replaced by Asp, Lys, Leu, Val or Ala and wherein B29 lysine could alternatively be Pro；Ala (B26) people's pancreas islet Element；Des (B28-B30) actrapid monotard；Des (B27) actrapid monotard；With Des (B30) actrapid monotard.
Insulin derivates such as B29-N- myristoyl-des (B30) actrapid monotard；B29-N- palmityl-des (B30) Actrapid monotard；B29-N- myristoyl human insulin；B29-N- palmitoyl human insulin；B28-N- myristoyl Lispro；B28-N- palmityl-Lispro；B30-N- myristoyl- ThrB29LysB30 actrapid monotard；B30-N- palmityl-ThrB29LysB30 actrapid monotard；B29-N- (N- palmityl-Y- paddy ammonia Acyl)-des (B30) actrapid monotard；B29-N- (N- stone gallbladder acyl-Y- glutamy)-des (B30) actrapid monotard；B29-N- (ω-carboxylic Base heptadecanoyl)-des (B30) actrapid monotard and B29-N- (ω-carboxyl heptadecanoyl) actrapid monotard.
Exendin-4 means such as exendin-4 (1-39), is the peptide with following sequences:
H
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu- Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro- Pro-Pro-Ser-NH2。
Exendin-4 derivative is for example selected from following compound lists:
H- (Lys) 4-des Pro36, des Pro37 exendin-4 (1-39)-NH2,
H- (Lys) 5-des Pro36, des Pro37 exendin-4 (1-39)-NH2,
Des Pro36 exendin-4 (1-39),
Des Pro36 [Asp28] exendin-4 (1-39),
Des Pro36 [IsoAsp28] exendin-4 (1-39),
Des Pro36 [Met (O) 14, Asp28] exendin-4 (1-39),
Des Pro36 [Met (O) 14, IsoAsp28] exendin-4 (1-39),
Des Pro36 [Trp (O2) 25, Asp28] exendin-4 (1-39),
Des Pro36 [Trp (O2) 25, IsoAsp28] exendin-4 (1-39),
Des Pro36 [Met (O) 14Trp (O2) 25, Asp28] exendin-4 (1-39),
Des Pro36 [Met (O) 14Trp (O2) 25, IsoAsp28] exendin-4 (1-39)；Or
Des Pro36 [Asp28] exendin-4 (1-39),
Des Pro36 [IsoAsp28] exendin-4 (1-39),
Des Pro36 [Met (O) 14, Asp28] exendin-4 (1-39),
Des Pro36 [Met (O) 14, IsoAsp28] exendin-4 (1-39),
Des Pro36 [Trp (O2) 25, Asp28] exendin-4 (1-39),
Des Pro36 [Trp (O2) 25, IsoAsp28] exendin-4 (1-39),
Des Pro36 [Met (O) 14Trp (O2) 25, Asp28] exendin-4 (1-39),
Des Pro36 [Met (O) 14Trp (O2) 25, IsoAsp28] exendin-4 (1-39),
Wherein-Lys6-NH2 group can be incorporated into the C-terminal of exendin-4 derivative；
Or the exendin-4 derivative of following sequences
Des Pro36 exendin-4 (1-39)-Lys6-NH2 (AVE0010),
H- (Lys) 6-des Pro36 [Asp28] exendin-4 (1-39)-Lys6-NH2,
Des Asp28Pro36, Pro37, Pro38 exendin-4 (1-39)-NH2,
H- (Lys) 6-des Pro36, Pro38 [Asp28] exendin-4 (1-39)-NH2,
H-Asn- (Glu) 5des Pro36, Pro37, Pro38 [Asp28] exendin-4 (1-39)-NH2,
Des Pro36, Pro37, Pro38 [Asp28] exendin-4 (1-39)-(Lys) 6-NH2,
H- (Lys) 6-des Pro36, Pro37, Pro38 [Asp28] exendin-4 (1-39)-(Lys) 6-NH2,
H-Asn- (Glu) 5-des Pro36, Pro37, Pro38 [Asp28] exendin-4 (1-39)-(Lys) 6- NH2,
H- (Lys) 6-des Pro36 [Trp (O2) 25, Asp28] exendin-4 (1-39)-Lys6-NH2,
H-des Asp28Pro36, Pro37, Pro38 [Trp (O2) 25] exendin-4 (1-39)-NH2,
H- (Lys) 6-des Pro36, Pro37, Pro38 [Trp (O2) 25, Asp28] exendin-4 (1-39)- NH2,
H-Asn- (Glu) 5-des Pro36, Pro37, Pro38 [Trp (O2) 25, Asp28] exendin-4 (1- 39)-NH2,
Des Pro36, Pro37, Pro38 [Trp (O2) 25, Asp28] exendin-4 (1-39)-(Lys) 6-NH2,
H- (Lys) 6-des Pro36, Pro37, Pro38 [Trp (O2) 25, Asp28] exendin-4 (1-39)- (Lys)6-NH2,
H-Asn- (Glu) 5-des Pro36, Pro37, Pro38 [Trp (O2) 25, Asp28] exendin-4 (1- 39)-(Lys)6-NH2,
H- (Lys) 6-des Pro36 [Met (O) 14, Asp28] exendin-4 (1-39)-Lys6-NH2,
Des Met (O) 14Asp28Pro36, Pro37, Pro38 exendin-4 (1-39)-NH2,
H- (Lys) 6-desPro36, Pro37, Pro38 [Met (O) 14, Asp28] exendin-4 (1-39)-NH2,
H-Asn- (Glu) 5-des Pro36, Pro37, Pro38 [Met (O) 14, Asp28] exendin-4 (1-39)- NH2,
Des Pro36, Pro37, Pro38 [Met (O) 14, Asp28] exendin-4 (1-39)-(Lys) 6-NH2,
H- (Lys) 6-des Pro36, Pro37, Pro38 [Met (O) 14, Asp28] exendin-4 (1-39)- (Lys)6-NH2,
H-Asn- (Glu) 5des Pro36, Pro37, Pro38 [Met (O) 14, Asp28] exendin-4 (1-39)- (Lys)6-NH2,
H-Lys6-des Pro36 [Met (O) 14, Trp (O2) 25, Asp28] exendin-4 (1-39)-Lys6- NH2,
H-des Asp28Pro36, Pro37, Pro38 [Met (O) 14, Trp (O2) 25] exendin-4 (1-39)- NH2,
H- (Lys) 6-des Pro36, Pro37, Pro38 [Met (O) 14, Asp28] exendin-4 (1-39)-NH2,
H-Asn- (Glu) 5-des Pro36, Pro37, Pro38 [Met (O) 14, Trp (O2) 25, Asp28] exendin Peptide -4 (1-39)-NH2,
Des Pro36, Pro37, Pro38 [Met (O) 14, Trp (O2) 25, Asp28] exendin-4 (1-39)- (Lys)6-NH2,
H- (Lys) 6-des Pro36, Pro37, Pro38 [Met (O) 14, Trp (O2) 25, Asp28] exendin-4 (S1-39)-(Lys)6-NH2,
H-Asn- (Glu) 5-des Pro36, Pro37, Pro38 [Met (O) 14, Trp (O2) 25, Asp28] exendin Peptide -4 (1-39)-(Lys) 6-NH2；
Or the pharmaceutically acceptable salt or solvate of aforementioned any exendin-4 derivative.
Pituitrin (the hypophysis that hormone is for example listed in Rote Liste, ed.2008, the 50th chapter ) or hypothalamic hormone (hypothalamus hormones) or modulability active peptide (regulatory active hormones Peptides) and their antagonist, such as promoting sexual gland hormone (follitropic hormone (Follitropin), metakentrin (Lutropin), human chorionic gonadtropin (Choriongonadotropin), Menotrophins (Menotropin)), Somatropine (growth hormone (Somatropin)), minirin (Desmopressin), terlipressin (Terlipressin), Gonadorelin (Gonadorelin), Triptorelin (Triptorelin), Leuprorelin (Leuprorelin), Buserelin (Buserelin), nafarelin (Nafarelin), Goserelin (Goserelin).
Polysaccharide such as glucosaminoglycan (glucosaminoglycane), hyaluronic acid (hyaluronic acid), liver The sulphation of element, low molecular weight heparin or ultra-low molecular weight heparin or derivatives thereof or aforementioned polysaccharide, such as poly-sulfated shape Formula and/or its pharmaceutically acceptable salt.One example of the pharmaceutically acceptable salt of poly-sulfated low molecular weight heparin is according to promise liver Plain sodium (enoxaparin sodium).
Antibody is spherical plasma proteins (~150kDa), also referred to as immunoglobulin, shares a kind of foundation structure.Cause There is the sugar chain for being added to amino acid residue for them, so they are glycoprotein.The basic function unit of each antibody is to exempt from Epidemic disease globulin (Ig) monomer (only contains an Ig unit)；The antibody of secretion be also possible to tool there are two Ig unit dimer such as There are five the five poly- of Ig unit there are four the IgM of the tetramer such as bony fish (teleost fish) of Ig unit or tool for IgA, tool The IgM of body such as mammal.
Ig monomer is Y-shaped molecule, is made of four polypeptide chains；Two identical heavy chains and two identical light chains, They pass through the disulfide bond connection between cysteine residues.Each heavy chain is about 440 amino acid；Every light chain is about 220 A amino acid.Each heavy chain and light chain contain intrachain disulfide bond, and intrachain disulfide bond stablizes their folding.Every chain is all by claiming It is constituted for the structural domain in the domain Ig.About 70-110 amino acid is contained in these domains, and is returned according to their size and function classification Enter different scopes (for example, variable or V, constant or C).They have characteristic immunoglobulin folding, two of them β piece Layer creates a kind of " sandwich " shape, and the shape is by the phase interaction between conservative cysteine and other electrically charged amino acid With and keep together.
There are five types of types for mammal Ig heavy chain, are expressed as α, δ, ε, γ and μ.The type of existing heavy chain determines antibody Isotype；These chains can be found in IgA, IgD, IgE, IgG and IgM antibody respectively.
The size and composition of different heavy chains are different；α and γ contains about 450 amino acid, and δ contains about 500 A amino acid, and μ and ε has about 550 amino acid.There are two areas, i.e. constant region (CH) and variable region for each heavy chain tool (VH).In a species, constant region is substantially the same in all antibody of same isotype, but different of the same race It is different in the antibody of type.Heavy chain γ, α and δ have constant region and strand for increased flexibility comprising three domains Ig of connecting Sequence；Heavy chain μ and ε have the constant region comprising four immunoglobulin domains.The variable region of heavy chain is being generated by different B cells It is different in antibody, but it is identical for all antibody generated by single B cell or single B cell clone. The variable region of each heavy chain is about 110 amino acid longs and includes the single domain Ig.
In mammals, there are two types of the light chain immunoglobulin of type, λ and κ are expressed as.There are two continuous for light chain tool Domain a: constant domain (CL) and a variable domain (VL).Light chain grows about 211 to 217 amino acid.Each antibody contains two Light chain, they are always the same；There is only a type of light chain κ or λ for each antibody in mammals.
As detailed above, although the general structure of all antibody is closely similar, the peculiar property of given antibody is It is determined by variable area (V).More specifically, variable loop -- there are three it is each on light chain (VL) and on heavy chain (VH) -- is responsible for In conjunction with antigen, i.e. antigentic specificity.These rings are referred to as complementary determining region (Complementarity Determining Regions, CDRs).It is heavy chain and light chain because the CDR from the domain VH and VL contributes antigen binding site Combination is rather than a single one determine final antigentic specificity.
" antibody fragment " contains at least one antigen-binding fragment as defined above, and presents complete with derivative antibody fragment Whole antibody substantially the same function and specificity.It is with papain (papain) restrictive proteolytic digestion that Ig is former Type is cracked into three segments.Two identical amino-terminal fragments are antigen-binding fragment (Fab), each segment contain one it is complete Whole L chain and approximately half of H chain.The third fragment is crystallizable fragment (Fc) that is similar in size but include is two heavy chains The half of carboxyl terminal, and have interchain disulfide bond.Fc contains sugar, complement-binding site and FcR binding site.It is restricted Pepsin (pepsin) digestion generate 2 segment of single F (ab') containing two Fab and hinge area comprising H-H interchain Disulfide bond.F (ab') 2 is divalent for antigen binding.The disulfide bond of F (ab') 2 can be cracked to obtain Fab'.This Outside, the variable region of heavy chain and light chain can be fused together to form single chain variable fragment (scFv).
Pharmaceutically acceptable salt such as acid-addition salts and basic salt.Acid-addition salts such as HCl or HBr salt.Basic salt for example has There are the cation selected from alkali or alkaline earth, such as the salt of Na+ or K+ or Ca2+ or ammonium ion N+ (R1) (R2) (R3) (R4), Middle R1 to R4 is independently of one another are as follows: hydrogen, the C1-C6 alkyl optionally replaced, the C2-C6 alkenyl optionally replaced, the C6- optionally replaced C10 aryl or the C6-C10 heteroaryl optionally replaced.More examples of pharmaceutically acceptable salt are in " Remington's Pharmaceutical Sciences"17.ed.Alfonso R.Gennaro(Ed.),Mark Publishing Company, It is described in Easton, Pa., U.S.A., 1985 and in Encyclopedia of Pharmaceutical Technology.
Pharmaceutical acceptable solvents close object such as hydrate.
Detailed description of the invention
Other feature, improvement and suitability becomes obvious from the following description of exemplary embodiment relevant to attached drawing.
Fig. 1 shows the exploded view of medicine delivery device,
Fig. 2 shows the sectional view of the medicine delivery device of Fig. 1 under the assembled state,
Fig. 3 shows the detailed view of rotating member, piston rod, piston rod nut and locking component,
Fig. 4 shows the detailed view of locking component,
Fig. 5 shows the schematic diagram of piston rod,
Fig. 6 shows the other embodiment of piston rod,
Fig. 7 shows the sectional view of the engagement of actuator and piston rod, locking component and coupling compoonent during dosage setting,
Fig. 8 shows the component of Fig. 7 with different section views,
Fig. 9 A and Fig. 9 B show under assembled state the portions of proximal of the medicine delivery device (without dosage setting),
Figure 10 shows the portions of proximal of medicine delivery device, and setting dosage amount is shown in indication window,
Figure 11 A and Figure 11 B show the medicine delivery device of Fig. 9 A and Fig. 9 B in the state that maximum dose has been set,
Figure 12 A and Figure 12 B show in the case of the medicament of doses is conveyed from device Fig. 9 A, Fig. 9 B, The medicine delivery device of Figure 11 A and Figure 11 B,
Figure 13 shows the coupling compoonent engaged with indicator with detailed view,
Figure 14 shows the schematic diagram of indicator and window widget,
Figure 15 A and Figure 15 B show the section of storage tube bracket and indicator,
Figure 16 shows the section of window widget,
Figure 17 A to Figure 17 C show during the operation of medicine delivery device in three different conditions window widget and Indicator,
Figure 18 A to Figure 18 C shows the engagement of final dose stop dog component and rotating member under three different conditions,
Figure 19 shows the section across the proximal end of medicine delivery device,
Figure 20 shows the engagement of rotating member and dose,
Figure 21 A to Figure 21 C shows according to fig. 20 dose and rotating member under three kinds of different conditions,
Figure 22 shows the alternate embodiment of the engagement of rotating member and dose,
The operation of mechanism when Figure 23 A to Figure 23 D explanation is activated with actuator,
Figure 24 shows the actuator and locking component during dosage distribution,
Figure 25 A to Figure 25 C shows being re-engaged for after dosage is the allocated actuator and locking component.
Specific embodiment
Fig. 1 shows the assembly path of the exploded view of medicine delivery device 101 and the component of medicine delivery device 101.Specifically Ground, medicine delivery device 101 are injection devices.Medicine delivery device 101 is variable dose device, so that user can choose agent The size of amount.Medicine delivery device 101 is configured for multi-dose application.Device can be ready to make being fully assembled User is transported in the state of.There are device low components to count and be special for the application of cost sensitivity device It is attracting.
Storage tube 118 is incorporated in storage tube bracket 117.Storage tube bracket 117 is rigidly constrained to shell 116.It causes Dynamic device 120 is constrained to storage tube bracket 117 in steering.Reset is provided between actuator 120 and storage tube bracket 117 Component 121.Reset components 121 can be such as spring.The axial force of reset components 121 is transferred to storage tube bracket 117 simultaneously And storage cylinder bracket 117 is offset.Piston rod 102 is configured to against the piston 119 being arranged in storage tube 118.Piston rod 102 are constructed such that piston 119 is moved to the direction of the distal end of device 111, to convey medicament from storage tube 118.It later will more Describe piston rod 102 in detail.
Medicine delivery device 101 further includes indicator 128, and indicator 128 is configured to instruction setting drug dose amount.Refer to Show that device 128 can be digital sleeve.Indicator 128 links to rotating member 123 by means of coupling compoonent 130.Rotating member 123 It can be sleeve.Window widget 147 is placed on indicator 128.Window widget 147 includes transparent material.Final dose backstop Component 124 is engaged by means of screw thread with rotating member 123.Final dose stop dog component 124 can be such as lock nut.Most Post dose stop dog component 124 is configured to the dosage for preventing setting to be greater than residual pharmacy amount in storage tube 118.Locking component 125 It is configured to engage with piston rod 102 with piston rod nut 126 (will be more fully described later).Piston rod nut 126 are configured to drive control component.Specifically, piston rod nut 126 acts on piston rod 102 for conveying doses Medicament.Spring member 127 is arranged between piston rod nut 126 and lid 131.Spring member 127 can be such as disc spring.? Dose 122 is provided at the proximal end 112 of device 101.
Fig. 2 shows the sectional views of the medicine delivery device 101 under assembled state.Specifically, Fig. 2 shows driving groups Part 180.Dose 122 can rotate to set the medicament of doses along dosage setting direction 113.Dosage setting Direction 113 can be for example clockwise.Setting and administered needed for power be consistent and be in storage tube 118 Power Xiang Duli needed for middle moving piston 119.Dose 122 can cancel the rotation of direction 114 along dosage to cancel Set drug dose.Dosage, which cancels direction 114, can be for example counterclockwise.The permission of medicine delivery device 101 is not distributing Cancel dosage in the case where the pharmaceutical quantities of any dosage.When dose 122 cancels direction along dosage setting or dosage 113,114 rotation when, rotating member 123 also due to the engagement of dose 122 and rotating member 123 and rotate, later This point will be described in further detail.Specifically, when rotating dose 122, rotating member 123 is relative to shell 116 Rotation.Rotating member 123 is axially fixed relative to shell 116.When rotating rotating member 123 during dosage setting, Piston rod nut 126 also rotates.Therefore, it rotates with piston rod nut 126 around piston rod 102, and is transported towards the proximal end of device 112 It is dynamic.When piston rod nut 126 is moved towards the proximal end of device 112, spring member 127 is between lid 131 and piston rod nut 126 It is compressed.Specifically, spring member 127 is stored the energy filled when the dosage needed for user's selection by compressing.The energy It is stored, until device is actuated to administered.In this regard, the energy being stored in spring member 127 be used to from Storage tube 118 conveys medicament to user.
Coupling compoonent 130 revolves around it component 123 and is concentrically arranged.During dosage setting, coupling compoonent 130 and rotation Turn component 123 to engage.In addition, coupling compoonent 130 is engaged with indicator 128.Indicator 128 is same around coupling compoonent 130 It is centrally located.Specifically, during the setting of dosage, coupling compoonent 130 is relative to rotating member 123 and relative to instruction Device 128 is fixed in steering.During dosage distribution, coupling compoonent 130 is engaged with locking component 125 and indicator 128.? During the setting and distribution of dosage, coupling compoonent 130 is configured to lead to the rotation of indicator 128.It will retouch in more detail later State coupling compoonent 130 and indicator 128.
Fig. 3 shows the more detailed view of rotating member 123, piston rod 102, piston rod nut 126 and locking component 125 Figure.
Piston rod nut 126 is in the state being threadedly engaged with piston rod 102.In addition, piston rod nut 126 is relative to rotation It is fixed in steering to turn component 123.This is realized by means of the spline 137 of piston rod nut 126, is bonded on rotating member In 123 axial notch 154.In an alternative embodiment, rotating member 123 and piston rod nut 126 can be by means of rotating structure Groove connection in spline and piston rod nut 126 in part 123.Piston rod nut 126 is relative to rotating member 123 along rotation The axial notch 154 for turning component 123 moves in the axial direction.During the setting and cancellation of dosage, piston rod 102 is relative to drug The shell 116 of conveying device 101 is fixed axially and in steering.This point is more fully described in figures 7 and 8.
During the setting or cancellation of dosage, piston rod nut 126 is together with rotating member 123 relative to medicine delivery device 101 shell 116 rotates, because piston rod nut 126 is fixed in steering relative to rotating member 123.Therefore, piston rod spiral shell Mother 126 rotates relative to piston rod 102.Due to being threadedly engaged for piston rod nut 126 and piston rod 102, piston rod nut 126 It is spirally connected along piston rod 102.This causes piston rod nut 126 to be transported in the axial direction relative to rotating member 123 and piston rod 102 It is dynamic.Specifically, the edge during dosage setting of piston rod nut 126 is moved towards the direction of the proximal end of device 112, and is taken in dosage Edge is moved towards the direction of the distal end of device during disappearing.In addition, locking component 125 is engaged with piston rod 102.Specifically, it locks Component 125 is threadedly engaged with piston rod 102.The screw thread of locking component 125 has opposite spiral relative to piston rod nut 126 Direction.During dosage setting, locking component 125 is fixed in steering relative to shell.Therefore, the piston during dosage setting The movement of bar 102 is suppressed.During dosage distribution, locking component 125 can be rotated relative to shell.Specifically, structure is locked Part 125 affects piston rod 102.Torque needed for causing locking component 125 to affect piston rod 102 is provided by spring member 127.
Fig. 4 shows the more detailed view of locking component 125.Locking component 125 is configured to lock nut.Lock structure Part 125 is engaged by means of screw thread 152 with piston rod thread.In addition, locking component 125 includes multiple splines 136.136 ring of spline Circumferentially it is arranged around the periphery of locking component 125.Spline 136 is configured to engage during dosage setting with actuator 120 And it is engaged during dosage distribution with coupling compoonent 130.Locking component 125 can further include the spline 153 extended.Extend Spline 153 can be set into and be evenly distributed between spline 136.The end of the spline 153 of extension extends to the end of spline 136 Except portion.The end of the spline 153 of extension can be chamfered.By means of the spline 153 of extension, it is possible to reduce misalignment tolerance. In addition, can permit the molding of locking component 125 due to the spline 153 of extension.Locking component 125 further includes flange 135.It borrows Help flange 135, locking component 125 is fixed in the axial direction relative to the shell 116 of medicine delivery device.Specifically, flange 135 Inner surface against the distal end of rotating member 123.During dosage setting, locking component 125 is due to the engagement with actuator 120 And it is fixed in steering relative to shell 116, this point will be more fully described referring for example to Fig. 7 later.
Fig. 5 shows the schematic diagram of piston rod 102.Piston rod 102 is driving screw.Piston rod 102 includes 103 He of the first screw thread Second screw thread 104.First and second screw threads 103,104 extend over the overall length of piston rod 102.First screw thread 103 and the second spiral shell Line 104 is oppositely oriented.The pitch 105 of first screw thread 103 is equal to the pitch 106 of the second screw thread 104.This is in order to ensure in dosage Indicator 128 is rotated back to its initial position during distribution.In an alternative embodiment, the pitch 105 of the first screw thread 103 It can be different from the pitch 106 of the second screw thread.Due to the first screw thread 103 and the second screw thread 104 be it is oppositely oriented, they mutually Intersect.First screw thread 103 and the second screw thread 104 are double threads.First screw thread 103 includes two screw thread starting points 181,182.The Two screw threads 104 include two screw thread starting points 183,184.Piston rod 102 includes at least one axial splines 115.For example, piston rod 102 may include two axial splines 115.Spline 115 continues along the whole length of piston rod 102.In Fig. 5, only one Spline 115 is visible.Second spline is arranged to opposite with the first spline 115.Specifically, spline 115 is arranged in steering Symmetrically.Spline 115 is configured to engage with the engagement feature 133 of actuator 120.Alternatively, piston rod 102, especially Spline 115 can be engaged directly with shell 116.Locking component 125 is engaged with the first screw thread 103 of piston rod 102.Engagement lock The pitch 105 of the first screw thread 103 of component 125 is determined for ensuring to be applied to the axial force of piston rod 102 in locking component 125 It is to close that sufficient torque, which is generated, to overcome the thrust bearing friction of the interface between locking component 125 and rotating member 123 Key.Piston rod nut 126 is engaged with the second screw thread 104 of piston rod 102.First screw thread 103 is right-handed thread.Second spiral shell Line 104 is left hand thread.
Fig. 6 shows the preferred embodiment of piston rod 102.Piston rod 102 shown in Fig. 6 is similar to living shown in Fig. 5 Stopper rod 102, other than the first internal diameter 107 of the first screw thread 103 is less than the second internal diameter 108 of the second screw thread 104.First internal diameter 107 be the minor diameter of the first screw thread 103.Second internal diameter 108 is the minor diameter of the second screw thread.Specifically, the first internal diameter 107 be from Twice of the distance on the surface of the pitch 105 of the 191 to the first screw thread of main shaft 103 of piston rod 102.Specifically, the second internal diameter 108 be from twice of the distance on the surface of the pitch 105 of the 191 to the second screw thread of main shaft 104 of piston rod 102.Specifically, One screw thread, 103 to the second screw thread 104 cuts deeper.(the first internal diameter 107 is less than the first internal diameter 107 with the first screw thread 103 The second diameter 108 of second screw thread 104) one of piston rod 102 the advantage is that the first screw thread 103 and with the first screw thread Contact diameter between 103 components (specifically, locking component 125) engaged can be smaller.Specifically, in the first screw thread There is only small contact surfaces between 103 and the component (specifically, locking component 125) that engages with the first screw thread 103.For regulation Thread pitch, contact diameter is smaller, and lead angle is bigger.Increasing lead angle reduces the frictional force occurred in hickey.Cause This is in piston rod 102 and affects the contact diameter between element smaller, and friction loss is smaller.Therefore it is mentioned by spring member 127 The influence of confession can keep smaller compared with the component of the piston rod 102 with larger interior diameter.Specifically, work as locking component 125 when affecting piston rod 102 during the distribution of dosage, it is necessary to overcome the friction between locking component 125 and piston rod 102 Power.Piston rod 102 and affect that contact surface between element, individually contact diameter is smaller, the frictional force is with regard to smaller.
Since the second internal diameter 108 is greater than the first internal diameter 107, piston rod 102 still has sufficient mechanical stability.
Piston rod 102 further includes axial splines, for clarity reason, these axial splines are not shown in the figure.Flower Key is configured to as shown in Figure 5.
Fig. 7 shows during dosage setting or when device is not used actuator 120 and piston rod in a non-operating condition 102, the engagement of locking component 125 and coupling compoonent 130.Actuator 120 is fixed in steering relative to shell 116.Actuator 120 include opening 172, and piston rod 102 extends through opening 172.Actuator 120 is special by means of the first engagement of actuator 120 Sign portion 132 is engaged with locking component 125.First engagement feature 132 of actuator 120 may include that such as setting is activating Spline or tooth at the recess portion 173 of device 120.The spline 136 of first engagement feature 132 and locking component 125 of actuator 120 It engages.When the first engagement feature 132 of actuator 120 is engaged with the spline 136 of locking component 125, locking component 125 relative to actuator 120 rotary motion be suppressed.Shell 116 due to actuator 120 relative to medicine delivery device exists It is fixed in steering, so when the first engagement feature 132 of actuator 120 is engaged with the spline 136 of locking component 125, Locking component 125 is also fixed in steering relative to shell 116.In addition, actuator 120 includes the second engagement feature 133, the Two engagement features 133 are engaged with the axial splines 115 of piston rod 102.Second engagement feature 133 is arranged in actuator At 120 opening 172.Second engagement feature 133 of actuator 120 may be constructed such that spline or protrusion.Therefore, piston rod The 102 permanently fixation in steering of shell 116 relative to medicine delivery device.In addition, actuator 120 and 130 phase of coupling compoonent Engagement.Specifically, actuator 120 includes snap features portion 155, the engagement feature in snap features portion 155 and coupling compoonent 130 156 engage.In the period of assembly of device, the snap features portion 155 of actuator 120 can engage the engagement of coupling compoonent 130 Features 156.Due to the engagement, coupling compoonent 130 is relative to for good and all axial restraint of actuator 120.
Fig. 8 shows the actuator 120 of Fig. 7 with sectional view.In this embodiment, the second engagement for showing actuator 120 is special Sign portion 133, the second engagement feature 133 are configured to engage with the axial splines 115 of piston rod 102.In addition, actuator 120 include protrusion 167, and protrusion 167 is engaged with the groove in storage tube bracket 117.Therefore, actuator 120 is relative to storing Cylinder bracket 117 is fixed in steering, and therefore fixed in steering relative to shell 116, because of 117 rigidity of storage tube bracket Ground is constrained to shell 116.However, allowing the restricted axial stroke of actuator 120.
Fig. 9 A and Fig. 9 B show the driving assembly 180 of the medicine delivery device 101 under assembled state.Fig. 9 B is with section Illustrate the driving assembly 180 of device 101.For setting dosage, dose 122 is rotated along dosage setting direction 113. When rotating dose 122, rotating member 123 also rotates.This is because rotating member 123 and dose 122 are connected.Rotating member 123 and dosage setting structure are described more fully later with reference to Figure 20 and Figure 21 A to Figure 21 C The connection of part 122.Since piston rod nut 126 is fixed in steering relative to rotating member 123, so piston rod nut 126 It is rotated with rotating member 123.Therefore, piston rod nut 126 is rotated around piston rod 102 and along piston rod 102 towards device 112 Proximal end move axially.When the proximal end moving piston stem nut 126 of present dynasty's device, its compressed spring component 127.Even if ought not When setting dosage, spring member 127 is also lightly compressed, because needing to be greater than at piston 119 for all dosage sizes The minimum force of 0N.When making dose 122 cancel direction along dosage to rotate, piston rod nut 126 is towards the distal end of device Movement, and the compression of spring member 127 is released.The lid 131 and nearside of piston rod nut 126 is arranged in spring member 127 Between face 134.The movement of the instruction of arrow 164 piston rod nut 126 during dosage setting.Arrow 165 is indicated in dosage setting The movement of period final dose stop dog component 124.Final dose backstop structure will be described more fully by 8A to Figure 18 C referring to Fig.1 Part 124 and its function.
When rotating during setting or cancellation of the rotating member 123 in dosage, coupling compoonent 130 and indicator 128 also revolve Turn.This is because coupling compoonent 130 is engaged with rotating member 123 and indicator 128 is engaged with coupling compoonent, in Figure 13 more It is illustrated in detail this point.Specifically, the rotation of coupling compoonent 130 leads to rotation and the axial translation of indicator 128.Work as instruction When device 128 rotates, dosage that the digital indication shown in indication window 129 has been set.In the either side of indication window 129 On individual digit be also can see with assist determine dose 122 required rotation, as shown in Figure 10.Figure 10 show the portions of proximal of the medicine delivery device 101 in the case where setting dosage amount is shown in indication window 129.
Specifically, during the setting of dosage and distribution the two, coupling compoonent 130 makes the rotation of indicator 128 to ensure just True dosage is shown by indication window 129.Indication window 129 is the notch in the shell of medicine delivery device.Window widget 147 are arranged between indicator 128 and indication window 129.It is defeated that window widget 147 can prevent dust or dirt from invading drug Send the shell of device.It can be with the dosage between a unit increment selection zero and predetermined maximum.It can choose within the scope of this Any dosage.One unit is such as 0.01ml.
Figure 11 A and Figure 11 B show medicine delivery device in the state that dosage has been set.Specifically, it has set Determine maximum dose.Maximum is such as 80 units.Figure 11 B shows device 101 with sectional view.Setting dosage amount is in indication window It is indicated in 129.Setting dosage amount is indicated by indicator 128.Indicator 128 is in its most proximal position.Spring member 127 by To the compression of piston rod nut 126.Compared with the position of the final dose stop dog component 124 shown in Fig. 9 B, final dose stops Gear component 124 is axially translated along proximal direction.When actuator 120 is actuated by a user, such as by the arrow in Figure 11 A It indicated by 166, is moved in particular along distal direction, setting drug dose is conveyed from medicine delivery device.When making actuator 120 When actuating, locking component 125 is detached from from actuator 120.The mechanism is more fully described later with reference to Figure 23 A to Figure 23 D.When When being detached from locking component 125 from actuator 120, locking component 125 can be rotated relative to shell 116.When locking component 125 When can rotate, piston rod 102 can be moved axially relative to shell 116.During distribution, when a dose is to be set, it locks Component 125 is turning to be driven up along the contrary direction with rotating member 123, and therefore, turns round indicator 128 To reduce the value of shown dosage.
When setting dosage and when actuator 120 is activated, piston rod 102 is along the distal end towards medicine delivery device 111 direction movement.Specifically, the applied force in the proximal side 134 of piston rod nut 126 of spring member 127.The power makes piston Distal movement of the bar 102 towards device.Specifically, piston rod 102 moves axially, but does not rotate relative to shell 116.Work as work When stopper rod 102 is moved along the direction of the distal end towards device, locking component 125 affects piston rod 102.During the distribution of medicament, Indicator 128 moves back to its initial position.
Figure 12 A and Figure 12 B show the medicine delivery device in the case where conveying doses medicament from device 101.Except piston rod 102, final dose stop dog component 124, dose 122 and rotating member 123, locking component 125 And all components except piston rod nut 126 are in their initial position.Specifically, it is initial to be in it for indicator 128 Position, so that showing digital " 0 " in indication window 129.
Figure 13 shows the coupling compoonent 130 engaged with indicator 128 with detailed view.Specifically, indicator 128 is turning It is constrained to coupling compoonent 130 upwards.This passes through the engagement device 143 of coupling compoonent 130 and the engagement device of indicator 128 144 engage to realize.For example, the engagement device 144 of indicator 128 can be and the corresponding groove in coupling compoonent 130 The spline engaged.Indicator 128 and coupling compoonent 130 remain engaged in the entire extent of axial travel of indicator 128.
Figure 14 shows the schematic diagram of indicator 128 and the window widget 147 being concentrically arranged around indicator 128.Refer to Show that device 128 is printed with the spirality path of number, the spiral shell of spiral pitch-matched link indicator 128 and window widget 147 The pitch of line.The screw thread 148 of link indicator 128 and window widget 147 is shown in FIG. 16.It is visible by window widget 147 Indicator 128 quantity correspond to setting dosage.Window widget 147 includes amplifier element so that number on indicator 128 It is more clear for a user.Indicator 128 includes at least one maximum dose butting section 145.Window widget 147 includes extremely A few maximum dose butting section 146.It is more than the dosage of specified amount that maximum dose butting section 146, which inhibits setting,.Indicator 128 is also Including at least one stop feature portion 170.Stop feature portion 170 be configured to when setting dosage completely be assigned when against The stop feature portion 171 of storage tube bracket 117.In alternative embodiment, stop feature portion 171 can be locked in shell On 116.Specifically, the end of distribution backstop is served as in stop feature portion 170.Additionally, driver plate backstop is served as in stop feature portion 170 End.This indicates that being unable to driver plate makes dosage be more than zero unit during dosage is cancelled.
The section of storage tube bracket 117 and indicator 128 is shown in Figure 15 A and Figure 15 B.In Figure 15 A, in dosage point With period, the stop feature portion 170 of indicator 128 is close to the stop feature portion 171 of storage tube bracket 117.In Figure 15 B, refer to Show stop feature portion 171 of the stop feature portion 170 against storage tube bracket 117 of device 128.When the stop feature of indicator 128 When portion 170 is against the stop feature portion 171 of storage tube bracket 117, further rotating for indicator 128 is suppressed.Therefore, storing Cylinder bracket 117 provides rotation backstop in the case where dosage conditions terminate for indicator 128.In addition, working as the rotation of indicator 128 When being suppressed, the rotation of coupling compoonent 130 is also suppressed.When the rotation of coupling compoonent 130 is suppressed, locking component 125 Rotation is suppressed.Therefore, the distribution of the medicament of doses is suppressed.
In Figure 16,147 part of window widget is illustrated in greater detail.Window widget 147 is configured to connect through screw thread 148 To indicator 128.In addition, window widget 147 includes engagement device 158.The engagement device 158 of window widget 147 is configured to It is engaged with shell 116.Therefore, window widget 147 is suppressed relative to the rotation of shell 116.Specifically, window widget 147 It is rigidly constrained to shell 116.For example, the engagement device 158 of window widget 128 can be spline.Alternatively, engagement dress Setting 158 can be groove.
Figure 17 A to Figure 17 C shows the window widget 147 and indicator during dosage setting under three kinds of different conditions 128.Indicator 128 is screwed to window widget 147, so that indicator 128 leads to indicator by the rotation of coupling compoonent 130 128 rotation and axial translation relative to window widget 147.During dosage setting, the maximum dose butting section of indicator 128 146 close to the maximum dose butting section 146 of window widget 147, as shown in Figure 17 A and Figure 17 B.When being set maximum dose When, the maximum dose butting section 145 of indicator 128 is against the maximum dose butting section 146 of window widget 147, such as institute in Figure 17 C Show.Therefore, indicator 128 further rotate it is suppressed.Therefore, setting is more than that the dosage of maximum dose is suppressed.Maximum agent Amount is visible by window widget 147.
Figure 18 A to Figure 18 C shows under three kinds of different conditions of device final dose stop dog component 124 relative to rotation structure The position of part 123.Rotating member 123 serves as final dose backstop drive member 190.Rotating member 123 is relative to final dose Stop dog component 124 allows the quantity rotated to be determined by the capacity of storage tube 118.Specifically, the movement of rotating member 123 causes The movement of final dose stop dog component 124.Final dose stop dog component 124 is fixed in steering, but can relative to shell 116 It moves in the axial direction.This is realized by means of at least one protrusion 176 of final dose stop dog component 124, at least one protrusion 176 are configured to engage with shell 116, such as engage at least one axial notch 177 (referring to fig. 2) of shell 116. Final dose stop dog component 124 is engaged by means of screw thread 161 with rotating member 123.Final dose stop dog component 124 includes most Post dose stop dog component butting section 159.Figure 18 A shows the last agent before being set any dosage in a position Measure stop dog component 124.When rotating member 123 is rotated along dosage setting direction 113, final dose stop dog component 124 is along rotation Turn component 123 to move towards the proximal end of device.When remaining only a small amount of medicament in storage tube, the final dose of rotating member 123 Stop surface 160 close to final dose stop dog component 124 final dose stop surface 159, as in Figure 18 B it can be seen that.When When the final dose stop surface 160 of rotating member is against the final dose stop surface 159 of final dose stop dog component 124, such as scheme Shown in 18C, further dosage setting is suppressed.This is because rotating member 123 is along the further of dosage setting direction 113 Rotation be suppressed.Therefore, the dosage that setting is greater than remaining drug dose in storage tube is suppressed.But by making to rotate It is still possible that component 123, which cancels the rotation of direction 114 along dosage come the setting dosage for cancelling medicament,.When 123 edge of rotating member When dosage cancels the rotation of direction 114, final dose stop dog component 124 is moved towards the distal end of device 111.
Figure 19 shows the section across the proximal end of medicine delivery device.The section is shown by means of the protrusion in shell 116 169 form axial constraint between shell 116 and dose 122.In addition, showing the layout of lid 131.Lid 131 is by about Beam is in dose 122.Remote surface of the lid 131 through 178 exposure dose setting element 122 of small-diameter bearings.By this Interface, the power of the piston 119 acted on piston rod 102 are transferred to shell 116 and are offset by shell 116.Specifically, small Diameter bearing 178 is that rotating member 123 provides bearing.In addition, spring member 127 contacts lid 131.Lid 131 is through binding characteristic portion 175 are axially fixed to rotating member 123, and binding characteristic portion 175 is engaged with rotating member 123.
Figure 20 shows the engagement of rotating member 123 Yu dose 122.Rotating member 123 is installed in lid 131 On.Dose 122 includes at least one such as two ratchet feature portion 140.Ratchet feature portion 140 is configured to dosage Recess in setting element 122.Rotating member 123 includes at least one such as two arm of ratchet 141.The spine of rotating member 123 Wheel arm 141 is engaged with the ratchet feature portion 140 of dose 122.When dose 122 does not rotate, for example, During dosage distribution, or along dosage setting direction rotating dose setting member 122, arm of ratchet 141 is against dose 122 ratchet feature portion 140.When the axial spring forces provided by spring member 127 act on piston rod nut 126, Attempt to affect the hickey between piston rod 102 to generate torque by piston rod nut 126.Because due to piston rod nut 126 may not affect piston rod 102 with the engagement of rotating member 123, piston rod nut 126, and direct tangential force is transferred to rotation structure Part 123.Thus, it is possible to rotating member 123 is caused to rotate, for example, during dosage is cancelled, when the arm of ratchet of rotating member 123 141 when being not against the ratchet feature portion 140 of dose 122.During the cancellation of dosage, in arm of ratchet 141 and ratchet There may be the spaces that the duration is short between features 140.Specifically, during the cancellation of dosage, arm of ratchet 141 can be from spine Wheel features 140 are detached from the short duration.In addition, the arm of ratchet 141 of rotating member 123 and the shell of medicine delivery device Shell ratchet feature portion 142 engages.Shell ratchet feature portion 142, which can be, to be for example located at the inner periphery of shell 116 Multiple teeth or recess.
Ratchet interface between dose 122 and shell 116 ensures, when user releases after setting dosage When putting dose 122, acting on the torque generated on piston rod nut 126 by spring member 127 returns to device not To zero unit location.Zero unit location is the position of not setting dosage unit.
Figure 21 A to Figure 21 C shows according to fig. 20 dose 122 and rotating member 123, specifically, is in three The ratchet feature portion 140 of dose 122 in the state that kind is different and the arm of ratchet 141 of rotating member 123.
The engagement of dose 122 and rotating member 123 in the state that Figure 21 A is shown during dosage setting.When When dose 122 is rotated along dosage setting direction 113, since arm of ratchet 141 and the ratchet of dose 122 are special The engagement in sign portion 140, rotating member 123 are rotated with dose 122.Specifically, dose 122 acts on spine On the sagittal plane 179 of wheel arm 141, and rotate rotating member 123 directly, force it and shell ratchet feature portion 142 with Recess or tooth engage afterwards.Ratchet feature portion 140 is configured to the recess in dose 122.Dose 122 Inner periphery slightly extend over the shell ratchet feature portion 142 of shell along the direction of the longitudinal axis towards medicine delivery device. Specifically, the ratchet feature portion 140 of dose 122 is amplified relative to shell ratchet feature portion 142.Therefore, work as agent When measuring setting element 122 along the rotation of dosage setting direction 113, the arm of ratchet 141 of rotating member 123 can be from shell ratchet feature Portion 142 is detached from, but cannot be detached from from the ratchet feature portion 140 of dose 122.The angle of chamfer in ratchet feature portion 140 Degree reduces to ensure at it before ratchet feature portion 140 arm of ratchet 141 and shell ratchet feature portion 142 fully again Engagement.This prevents user from undergoing impact load by dose 122.When arm of ratchet 141 and shell ratchet feature portion 142 When being re-engaged, audible feedback can be supplied to user.In addition, shell ratchet feature portion 142 can inhibit 123 edge of rotating member The unexpected rotation in dosage cancellation direction.
Figure 21 B show in dose 122 do not rotate in the state of rotating member 123 and dose 122.During the rotation of dose 122, this state may also temporarily occur.In this state, rotating member Arm of ratchet 141 fully engaged with the ratchet feature portion 140 of dose and with shell ratchet feature portion 142.
Figure 21 C shows rotating member 123 and dose 122 during dosage is cancelled.When making dosage setting structure When part cancels the rotation of direction 114 along dosage, arm of ratchet 141 is temporarily dropped off from the ratchet feature portion 140 of dose.This Outside, arm of ratchet 141 is detached from from shell ratchet feature portion 142.This is because arm of ratchet 141 is by dose 122 along diameter It is turned to inward direction.Dose 122 on this inclined surface 185 by acting on arm of ratchet 141 is realized.Due to Torque on rotating member 123 is acted on by spring member 127, rotating member is cancelled direction along dosage and rotated, until arm of ratchet 141 are re-engaged with the ratchet feature portion 140 of dose.Dose 122 now can be along increaseing or decreasing Either setting dosage is to rotation.
Figure 22 shows the alternate embodiment of dose 122.In this embodiment, required arm of ratchet spring force subtracts It is small.Therefore, torque reduction is selected.The embodiment includes additional engagement feature 162, adds engagement feature 162 and rotation structure The butting section of part 123 engages.Additional engagement feature 162 is configured to lug.Dose 122 includes two convex Ear.When dose 122 is rotated along dosage setting direction 113, between dose 122 and rotating member 123 Bond strength increase.In addition, this engagement, which cancels direction 114 along dosage, drives rotating member 123.Dose 122 Engagement feature 162 be constructed such that rotating member 123 along dosage setting direction 113 rotate.Therefore, rotating member 123 Arm of ratchet 141 is removed during dosage setting.Accordingly it is possible to prevent arm of ratchet 141 is impaired.Specifically, arm of ratchet 141 executes Resist the simple function that the torque generated on piston rod nut 126 is acted on by spring member 127.Specifically, they are not by agent The rotation for measuring setting element 122 is transmitted to rotate rotating member 123.The rotation of rotating member 123 is only by means of engagement feature 162 realize.Additional benefits are the sliding friction interfaces removed between dose 122 and arm of ratchet 141.
Figure 23 A to Figure 23 D explains the operation of the mechanism when actuator 120 is activated and dosage is assigned.Actuating actuating Power needed for device 120 and actuator must move apart from very little, significant ergonomic advantages are provided, especially for tool For having such user of impaired flexibility.
Figure 23 A shows the mechanism before actuator 120 is activated.Locking component 125 is engaged with actuator 120, and And it is therefore fixed in steering relative to the shell of medicine delivery device 116.Due to coupling compoonent 130 and rotating member 123 Engagement, coupling compoonent 130 is fixed in steering relative to rotating member 123, and then at lock state.Specifically, only User not rotating dose setting member 122 are wanted, coupling compoonent 130 would be at lock state.Since locking component 125 is due to it Engagement with actuator 120 and be in its lock state, so piston rod 102 is in the axial direction and solid in steering relative to shell It is fixed.Specifically, locking component 125 is non-rotatable relative to piston rod 102.When make actuator 120 towards device distal end transport When dynamic, as shown in Figure 23 B, coupling compoonent 130 moves together with actuator 120.This is because the snap features portion of actuator 155 with the engagement of the engagement feature 156 of coupling compoonent 130.Since the flange 135 of locking component 125 is against rotating member 123 Surface, locking component 125 keeps in its axial position.
When making actuator 120 towards distal direction further movement (as shown in figure 21b), coupling compoonent 130 is drawn into It is engaged to the spline 136 with locking component 125.Therefore, coupling compoonent 130 is fixed in steering relative to locking component 125. When actuator 120 has arrived at position as shown in figure 23 c, coupling compoonent 130 is completely disengaged from rotating member 123.When When actuator 120 has arrived at position shown in Figure 23 D, the engagement between locking component 125 and actuator 120 is released. Specifically, the first engagement feature 132 of actuator 120 is detached from from the spline 136 of locking component 125.When locking component 125 from When actuator 120 completely disengages, it can be rotated relative to shell 116.Therefore, enable piston rod 102 relative to shell 116 move axially.When moving piston rod 102, specifically, when enabling locking component 125 to rotate, spring structure The power of part 127 is released.Specifically, spring member 127 is enabled to relax.Specifically, piston rod 102 passes through spring member 127 power is moved along distal direction.Specifically, spring member applied force on piston rod nut 126, thus makes piston rod nut 126 move together with piston rod 102.Therefore, locking component 125 affects piston rod 102.
When spring member 127 acts in the proximal face of piston rod nut 126, thus make piston rod 102 along distal side Direction movement, the flange 135 of locking component 125 squeeze the inner surface of rotating member 123.Therefore, the rotation of locking component 125 by To obstruction.When the torque needed for affecting piston rod 102 is small, then the power of the spring member 127 on piston rod nut 126 is acted on It may reduce, and locking component 125 squeezes the inner surface of rotating member 123 with smaller power.Therefore, in locking component 125 Flange 135 and rotating member 123 inner surface between the frictional dissipation of interface can reduce.This can be by using work Stopper rod 102 is realized, wherein internal diameter 108 of the internal diameter 107 of the first screw thread 103 less than the second screw thread 104.This is shown in FIG. 6 The piston rod 102 of sample.
Since coupling compoonent 130 is engaged with the spline 136 of locking component 125, coupling compoonent 130 is in company with locking component 125 Rotation.Specifically, coupling compoonent is rotated along the direction opposite with the rotation of coupling compoonent 130 during dosage setting.Therefore, join Structural member 130 makes the rotation of indicator 128 be back to its initial position.
Reset components 121 act in the proximal side of storage tube bracket 117.It provide screen resilience in proximal direction with Actuator 120 is set to be back to its initial position when user discharges actuator 120.
Figure 24 shows the actuator 120 and locking component 125 during dosage distribution.In this state, so that locking Component 125 can specifically be rotated relative to actuator 120 relative to the shell of medicine delivery device.Actuator 120 includes anti- Features 163 are presented, feedback characteristic portion 163 can be such as flexible arm.It feedback characteristic portion 163 can be with the spline of locking component 125 136 lightly engage.When locking component 125 rotates, specifically when spline 136 is by feedback characteristic portion 163, feedback is special Sign portion 163 turns to (in particular along the direction of the longitudinal axis far from medicine delivery device) in a radially outer direction.When a flower When key passes through feedback characteristic portion 163, audible click is generated.Specifically, do not turn when feedback characteristic portion 163 is promptly back to it When to position, click is generated.Each click corresponds to the distribution of individual unit.This is because on locking component 125 The quantity of spline 136 is equal to the quantity for the unit distributed during a rotation of locking component 125.
Figure 25 A to Figure 25 C show after administered and actuator 120 have been released actuator 120 with Locking component 125 re-engages with.When actuator 120 is released, the first engagement feature 132 and the locking structure of actuator 120 The spline 136 of part 125 re-engages with.The engagement feature 132 of actuator 120 tilts so that during re-engaging with, and locks structure The resistance of part 125 is rotated by the torque that spring member 127 generates.Therefore, locking component 125 unrolls small distance.Therefore, piston rod Retract small distance.This gap as caused by manufacturing tolerance unrolled in eliminating machine of locking component 125 influences.These tolerances In addition it will lead to the distribution of piston rod slightly advanced with drug dose.Unrolling for locking component 125 retracts piston rod 102 simultaneously And ensure that locking component 125 serves as distribution backstop instead of indicator 128.
Appended drawing reference
101 medicine delivery devices
102 piston rods
103 first screw threads
104 second screw threads
105 first segments away from
106 second pitches
107 first internal diameters
108 second internal diameters
The longitudinal axis of 109 devices
The longitudinal axis of 110 piston rods
The distal end of 111 devices
The proximal end of 112 devices
113 dosage setting directions
114 dosage cancel direction
The axial splines of 115 piston rods
116 shells
117 storage tube brackets
118 storage tubes
119 pistons
120 actuators
121 reset components
122 doses
123 rotating members
124 final dose stop dog components
125 locking components
126 piston rod nuts
127 spring members
128 indicators
129 indication windows
130 coupling compoonents
131 lids
First engagement feature of 132 actuators
Second engagement feature of 133 actuators
The proximal side of 134 piston rod nuts
The flange of 135 locking components
The spline of 136 locking components
The spline of 137 piston rod nuts
The bearing of 138 lids
The snap features portion of 139 lids
The ratchet feature portion of 140 doses
The arm of ratchet of 141 rotating members
142 shell ratchet feature portions
The engagement device of 143 coupling compoonents
The engagement device of 144 indicators
The maximum dose of 145 indicators against
The maximum dose of 146 window widgets against
147 window widgets
The screw thread of 148 window widgets
The end of 149 distribution backstops
150 distal directions
151 proximal directions
The screw thread of 152 locking components
The extension spline of 153 locking components
The axial notch of 154 rotating members
The snap features portion of 155 actuators
The engagement feature of 156 coupling compoonents
The engagement device of 158 window widgets
The final dose stop surface of 159 final dose stop dog components
The final dose stop surface of 160 rotating members
The screw thread of 161 rotating members
The engagement feature of 162 doses
163 feedback characteristic portions
164 arrows
165 arrows
The protrusion of 167 actuators
168 amplifier elements
169 protrusions
The stop feature portion of 170 indicators
The stop feature portion of 171 storage tube brackets
The opening of 172 actuators
173 recess
The binding characteristic portion of 175 lids
The protrusion of 176 final dose stop dog components
The axial notch of 177 shells
178 small-diameter bearings
The inclined surface of 179 arm of ratchet
180 driving assemblies
181 screw thread starting points
182 screw thread starting points
183 screw thread starting points
184 screw thread starting points
The inclined surface of 185 arm of ratchet
190 final dose backstop drive members
191 main shafts

Claims (17)

1. one kind be used for medicine delivery device (101) driving assembly (180), the driving assembly include: spring member (127), Piston rod (102) and the piston rod nut (126) engaged with piston rod (102), wherein piston rod nut (126) is constructed At during dosage setting relative to driving assembly (180) shell rotate and move in the axial direction, wherein when in dosage setting When period moving piston stem nut (126), spring member (127) is pressed, wherein the piston rod nut during dosage distribution (126) fixed in steering relative to the shell, and wherein driving assembly (180) includes the locking structure with lock state Part (125), wherein locking component (125) is engaged with piston rod (102), and wherein, when locking component (125) is in its locking Under state, locking component (125) inhibits the relaxation of spring member (127).
2. driving assembly according to claim 1, wherein piston rod (102) can be in the axial direction during dosage distributes Movement, but it is fixed in steering.
3. driving assembly according to claim 1, wherein spring member (127) contact piston stem nut (126).
4. driving assembly according to claim 1, wherein piston rod nut (126) is configured to during dosage distributes Carry out the movement in axial, non-steering.
5. driving assembly according to claim 1, wherein spring member (127) is disc spring.
6. driving assembly according to claim 1, wherein piston rod (102) includes at least one screw thread, and wherein, Piston rod nut (126) is threadedly engaged with piston rod (102).
7. driving assembly according to any one of claim 1 to 6, wherein locking component (125) and piston rod (102) It is threadedly engaged.
8. driving assembly according to any one of claim 1 to 6, wherein when locking component is discharged from its lock state When, locking component (125) can make spring member (127) relaxation.
9. driving assembly according to claim 7, wherein when locking component (125) is discharged from its lock state, piston Bar (102) is by spring member (127) to the distal movement of device (111).
10. driving assembly according to claim 8, wherein living when locking component (125) is discharged from its lock state Stopper rod (102) is by spring member (127) to the distal movement of device (111).
11. driving assembly according to claim 7, wherein locking component (125) is configured to lead during dosage distributes Piston bar (102).
12. driving assembly according to any one of claim 1 to 6 comprising actuator (120), the actuator is by structure It causes to start to convey drug dose from medicine delivery device (101), wherein spring member (127) is configured to when cause Relaxation when dynamic device (120) are activated.
13. driving assembly according to claim 12, wherein when actuator (120) is activated, locking component (125) It is released from its lock state.
14. driving assembly according to any one of claim 1 to 6 comprising rotating member (123), wherein in dosage During setting, piston rod nut (126) is rotated by the rotation of rotating member (123).
15. driving assembly according to any one of claim 1 to 6 comprising indicator (128), the indicator (128) It is configured to the amount of instruction setting dosage.
16. driving assembly according to claim 14 comprising indicator (128), the indicator (128) are configured to refer to Show the amount of setting dosage.
17. a kind of medicine delivery device (101) comprising the driving assembly of any one of claim 1~16.
CN201480057182.4A 2013-09-03 2014-09-03 Driving assembly for medicine delivery device and the medicine delivery device including driving assembly Active CN105682708B (en)

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EP13182757 2013-09-03
EP13182757.8 2013-09-03
PCT/EP2014/068651 WO2015032778A1 (en) 2013-09-03 2014-09-03 Drive assembly for a drug delivery device and drug delivery device comprising a drive assembly

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EP3041532A1 (en) 2016-07-13
WO2015032778A1 (en) 2015-03-12
US10850039B2 (en) 2020-12-01
CN105682708A (en) 2016-06-15
DK3041532T3 (en) 2018-10-29
US20160271332A1 (en) 2016-09-22
HK1222145A1 (en) 2017-06-23
EP3041532B1 (en) 2018-07-11
JP6517810B2 (en) 2019-05-22

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