CN105676907B - A kind of temperature control equipment and constant-temperature control method - Google Patents
A kind of temperature control equipment and constant-temperature control method Download PDFInfo
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- CN105676907B CN105676907B CN201610177272.8A CN201610177272A CN105676907B CN 105676907 B CN105676907 B CN 105676907B CN 201610177272 A CN201610177272 A CN 201610177272A CN 105676907 B CN105676907 B CN 105676907B
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- resistive heater
- temperature
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- temperature control
- reagent
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- 238000000034 method Methods 0.000 title claims description 15
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 42
- 238000001816 cooling Methods 0.000 claims abstract description 18
- 239000011241 protective layer Substances 0.000 claims abstract description 6
- 238000010438 heat treatment Methods 0.000 claims description 20
- 238000005057 refrigeration Methods 0.000 claims description 10
- 238000004458 analytical method Methods 0.000 claims description 5
- 238000007710 freezing Methods 0.000 claims description 3
- 230000008014 freezing Effects 0.000 claims description 3
- 238000013519 translation Methods 0.000 claims description 3
- 238000010792 warming Methods 0.000 claims description 3
- 238000009413 insulation Methods 0.000 claims description 2
- 239000010410 layer Substances 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 description 7
- 238000010586 diagram Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 4
- 239000004411 aluminium Substances 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000005611 electricity Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 2
- 230000003321 amplification Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D23/00—Control of temperature
- G05D23/19—Control of temperature characterised by the use of electric means
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- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Automation & Control Theory (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Control Of Temperature (AREA)
Abstract
The invention discloses a kind of temperature control equipments comprising: the top end surface of pallet and the shaft for driving pallet rotation, pallet is equipped with several reagent positions and several sample bits, and reagent position and sample bit are blind hole；The first resistive heater is equipped in hollow gap between shaft and the reagent position, the first resistive heater is used to heat the reagent in the reagent position；The periphery of sample bit is equipped with the second resistive heater, and the outside of the second resistive heater is equipped with insulating protective layer, and the second resistive heater is used to heat the sample in the sample bit；The tray bottom of pallet is hollow structure, and tray bottom includes the first chassis and the second chassis, cooling piece is equipped between the first chassis and the second chassis, cooling piece is adjacent to the bottom surface on first chassis.Its temperature control adjusts high-efficient, accuracy of temperature control height, and at low cost.
Description
Technical field
The present invention relates to medical instrument domain of control temperature, and in particular to a kind of temperature control equipment and thermostatic control side
Method.
Background technique
It includes that blood coagulation analyzer needs to configure temperature control equipment to meet detection working condition that two classes, which examine medical instrument,
Under demand to temperature control.In order to improve equipment operating efficiency, existing frequently-used inspection class Medical Devices mostly use revolver
As sample and reagent position device, this kind of equipment is related to blood class and test agent pattern detection mostly, and blood class and test
Reagent generally requires to save at normal temperature to the more demanding of temperature, blood class sample, and reagent requirement saves at 2 DEG C -8 DEG C,
It then requires to work under 37 DEG C of states when detection, and temperature control requirement is ± 0.5 DEG C.
Now as design particularity of the rotation class detection device in structure, this kind of device be difficult to carry out accurately to freeze and
The temperature control accurately heated.
Summary of the invention
It is an object of the invention to overcome problem above of the existing technology, a kind of temperature control equipment and constant temperature are provided
Control method, temperature control equipment of the invention are rotary integrated device, can be realized the accurate temperature freezed and accurately heated
Degree control, and device temperature control adjusting is high-efficient, it is at low cost, it can satisfy rotary in the coagulation analysis class device of domestic market
The demand of temperature control device development.
To realize above-mentioned technical purpose and the technique effect, the invention is realized by the following technical scheme:
A kind of temperature control equipment comprising:
The top end surface of pallet, the pallet is equipped with several reagent positions and several sample bits, the reagent position and sample
Position is blind hole, circumferentially arranges at equal intervals between several reagent positions, is at equal intervals between several sample bits
The periphery of the reagent position is arranged in circumferential arrangement, the sample bit；
Shaft, the shaft are able to drive the pallet rotation through the tray center；
The first resistive heater, the first heating electricity are equipped in hollow gap between the shaft and the reagent position
The outside for hindering silk is equipped with insulating protective layer, and first resistive heater is used to heat the reagent in the reagent position；
The periphery of the sample bit is equipped with the second resistive heater, and the outside of second resistive heater is equipped with insulation and protects
Sheath, second resistive heater are used to heat the sample in the sample bit；
The tray bottom of the pallet is hollow structure, and the tray bottom includes the first chassis and the second chassis, the sample
The bottom of position is second chassis, and the bottom of the reagent position is first chassis, first chassis and the second chassis
Between be equipped with cooling piece, the cooling piece is adjacent to the bottom surface on first chassis, and the cooling piece is for freezing.
Preferably, further include temperature sensor, temperature sensor setting first chassis and the second chassis it
Between.
Preferably, the heating temperature of first resistive heater and the second resistive heater can reach 37 DEG C ± 0.5
℃。
Preferably, first resistive heater and the thermostatically controlled temperature error of the second resistive heater be 37 DEG C ±
0.1℃。
Preferably, the cryogenic temperature of the cooling piece can be to 14 DEG C ± 2 DEG C.
Preferably, a kind of constant-temperature control method, comprising the following steps:
S1 MCU unit is sent according to pre-set heating, refrigeration and temperature control process parameter to sample bit, reagent position
Temperature control order；
S2 for the first resistive heater of reagent position heating, the second resistive heater for being heated on sample bit and
Cooling piece carries out various unit warming operations, refrigerating operation according to the order received；
The temperature signal monitored is transferred to chip NE5532 by S3 temperature sensor, and sensor signal passes through chip
After NE5532 signal amplifier, it is transferred to MCU unit；
S4 MCU unit carries out the analysis of analog signal A/D translation operation, calculates the target temperature of current temperature value and setting
Between relationship, the first resistive heater and the second resistive heater are controlled, if current temperature value is than the temperature of setting
Degree is high, the heater for closing the first resistive heater and the second resistive heater is controlled by MCU unit, if current temperature value ratio
The temperature of setting is low, and the heater for opening the first resistive heater and the second resistive heater is controlled by MCU unit；
Temperature controlled implementing result is transferred to MCU unit by S5.The beneficial effects of the present invention are:
One, temperature control equipment of the invention are a kind of rotary sample devices, which is equipped with sample bit, reagent
Position carries the pallet of above-mentioned sample bit and reagent position using aluminium material, aluminium material has good heating conduction, and selects
It is arranged under mandrel using hollow structure, facilitates refrigeration component and the export of temperature sensor control line, refrigeration component is using electricity
Cooling piece.
Secondly, the thermostatic control error of temperature control equipment of the invention and method only at 37 DEG C ± 1 DEG C, error range
Small, measurement accuracy is high, can guarantee that instrument high quality is run.
The above description is only an overview of the technical scheme of the present invention, in order to better understand the technical means of the present invention,
And can be implemented in accordance with the contents of the specification, the following is a detailed description of the preferred embodiments of the present invention and the accompanying drawings.
A specific embodiment of the invention is shown in detail by following embodiment and its attached drawing.
Detailed description of the invention
It in order to more clearly illustrate the technical solutions in the embodiments of the present invention, below will be in embodiment technical description
Required attached drawing is briefly described, it should be apparent that, the accompanying drawings in the following description is only some realities of the invention
Example is applied, it for those of ordinary skill in the art, without creative efforts, can also be according to these attached drawings
Obtain other attached drawings.
Fig. 1 is the structural schematic diagram of temperature control equipment of the present invention；
Fig. 2 is the A-A sectional view of Fig. 1；
Fig. 3 is the enlarged diagram of part A in Fig. 2；
Fig. 4 is the schematic diagram of intelligent temperature control of the present invention；
Fig. 5 is the wiring diagram of intelligent temperature control of the present invention；
Fig. 6 is principle of heating figure；
Fig. 7 is schematic diagram of refrigerating.
Wherein, 1- pallet, 2- shaft, 101- reagent position, 102- sample bit, the first resistive heater of 103-, 104- second
Resistive heater, 105- insulating protective layer, the first chassis 106-, the second chassis 107-, 108- cooling piece.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Embodiment
A kind of temperature control equipment is disclosed referring to Fig.1 shown in -3, in the present embodiment, which is rotary
Device mainly includes pallet 1 and shaft 2, wherein above-mentioned pallet 1 is the device for carrying reagent and sample, above-mentioned shaft 2
Above-mentioned pallet 1 is able to drive under the drive of rotating electric machine to rotate.
Specific structure between them are as follows: if being equipped with several reagent positions 101 and dry sample in the top end surface of above-mentioned pallet 1
One's own department or unit 102, mentioned reagent position 101 and sample bit 102 are blind hole, between several mentioned reagent positions 101 at equal intervals circumferentially
It arranges, is circumferentially arranged at equal intervals between several above-mentioned sample bits 102, above-mentioned sample bit 102 is arranged in mentioned reagent position 101
Periphery.
Above-mentioned shaft 2 is able to drive above-mentioned pallet rotation through above-mentioned 1 center of pallet, and above-mentioned shaft 2 is driven by rotating electric machine
Move its rotation.
Because the temperature control equipment in the present embodiment can be realized it is automatic temperature-controlled, the device be provided with heating unit device
Part is equipped with the first resistive heater in the hollow gap between above-mentioned shaft 2 and mentioned reagent position 101 with refrigeration component
103, the outside of above-mentioned first resistive heater 103 is equipped with insulating protective layer, and above-mentioned first resistive heater 103 is for heating
State the reagent in reagent position 101.
The periphery of above-mentioned sample bit 102 is equipped with the second resistive heater 104, the outside of above-mentioned second resistive heater 104
Equipped with insulating protective layer 105, above-mentioned second resistive heater 104 is used to heat the sample in above-mentioned sample bit 102.
The export of above-mentioned heating component and sensor conductor for convenience, the tray bottom of above-mentioned pallet 1 is designed to
Hollow structure, i.e., above-mentioned tray bottom include the first chassis 106 and the second chassis 107, and the bottom of above-mentioned sample bit 102 is above-mentioned second
The bottom on chassis 107, mentioned reagent position 101 is above-mentioned first chassis 106, between above-mentioned first chassis 106 and the second chassis 107
Equipped with cooling piece 108, above-mentioned cooling piece 108 is adjacent to the bottom surface on above-mentioned first chassis 106, and above-mentioned cooling piece 108 is for freezing.
And it is also provided with temperature sensor, above-mentioned temperature sensor is arranged on above-mentioned first chassis 106 and the second chassis
Between 107.The hollow structure of above-mentioned tray bottom is arranged, and facilitates the conducting wire export of heating component and sensor.
In the present embodiment, the heating temperature of above-mentioned first resistive heater 103 and the second resistive heater 104 can reach
To 37 DEG C ± 0.5 DEG C, the cryogenic temperature of above-mentioned cooling piece 108 can be to 14 DEG C ± 2 DEG C, above-mentioned first resistive heater, 103 He
The thermostatically controlled temperature error of second resistive heater 104 is 37 DEG C ± 0.1 DEG C.Therefore, which can meet in structure
The demand of rotation and temperature control, and temperature controlled precision is higher.
In the present embodiment, in order to preferably conduct heat, the temperature control efficiency of above-mentioned temperature control equipment is improved, on
Pallet is stated using aluminium material.
As shown in figs. 4-7, the temperature control method and principle of above-mentioned temperature controlled device are as follows:
S1 MCU unit is sent according to pre-set heating, refrigeration and temperature control process parameter to sample bit, reagent position
Temperature control order.
S2 for the first resistive heater of reagent position heating, the second resistive heater for being heated on sample bit and
Cooling piece for whole device refrigeration carries out various unit warming operations, refrigerating operation according to the order received.
The temperature signal monitored is transferred to chip NE5532 by S3 temperature sensor, and sensor signal passes through chip
After NE5532 signal amplifier, it is transferred to MCU cellular system.
S4 MCU cellular system carries out operational analysis after carrying out analog signal A/D conversion, calculates current temperature value and setting
Target temperature between relationship, the first resistive heater and the second resistive heater are controlled, if current temperature value
It is higher than the temperature of setting, the heater for closing the first resistive heater or the second resistive heater is controlled by MCU cellular system,
If current temperature value is lower than the temperature of setting, is controlled by MCU cellular system and open the first resistive heater or the second heating electricity
Hinder the heater of silk.
Temperature controlled implementing result is transferred to MCU unit by S5.
The working principle of the present embodiment is as follows:
MCU unit sends various lives according to pre-set heating, refrigeration and temperature control process parameter, to detector cell
It enables, detector cell is controlled according to trace point setting, the gain that the order received carries out temperature, executes corresponding temperature control
Operation, and the result for returning to execution as needed gives MCU unit.
Temperature signal is transferred to detector by temperature control unit, and the heating component on detector and refrigeration component connect
It begins to warm up and freezes after to order, the temperature signal that sensor obtains is transferred to signal condition amplifying unit, by signal tune
It is transferred to ADC unit after reason amplifying unit amplification, ADC unit converts a signal into digital quantity signal (real time temperature numerical value), number
Value is read by host.
Thermostatic control is sensor signal value through NE5532 chip signal amplifier, transmits MCU cellular system and carries out simulation letter
The analysis of number A/D translation operation calculates current temperature value and sets the relationship between target temperature, carries out on-off to system heating source
Control.If current temperature value is higher than set temperature, shutdown heater is controlled by MCU cellular system；If current temperature value ratio is set
It is low to determine temperature, heater is controlled by MCU cellular system；Constant temperature error meets demand for control at 37 ± 0.1 DEG C.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be readily apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest scope of cause.
Claims (6)
1. a kind of temperature control equipment, characterized in that it comprises:
The top end surface of pallet, the pallet is equipped with several reagent positions and several sample bits, and the reagent position and sample bit are equal
It for blind hole, is circumferentially arranged at equal intervals between several reagent positions, between several sample bits at equal intervals circumferentially
The periphery of the reagent position is arranged in arrangement, the sample bit；
Shaft, the shaft are able to drive the pallet rotation through the tray center；
The first resistive heater, first resistive heater are equipped in hollow gap between the shaft and the reagent position
Outside be equipped with insulating protective layer, first resistive heater is used to heat reagent in the reagent position；
The periphery of the sample bit is equipped with the second resistive heater, and the outside of second resistive heater is equipped with insulation protection
Layer, second resistive heater are used to heat the sample in the sample bit；
The tray bottom of the pallet is hollow structure, and the tray bottom includes the first chassis and the second chassis, the sample bit
Bottom is second chassis, and the bottom of the reagent position is first chassis, between first chassis and the second chassis
Equipped with cooling piece, the cooling piece is adjacent to the bottom surface on first chassis, and the cooling piece is for freezing.
2. a kind of temperature control equipment according to claim 1, which is characterized in that it further include temperature sensor, the temperature
Sensor is spent to be arranged between first chassis and the second chassis.
3. a kind of temperature control equipment according to claim 1, which is characterized in that first resistive heater and second
The heating temperature of resistive heater can reach 37 DEG C ± 0.5 DEG C.
4. a kind of temperature control equipment according to claim 3, which is characterized in that first resistive heater and second
The thermostatically controlled temperature error of resistive heater is 37 DEG C ± 0.1 DEG C.
5. a kind of temperature control equipment according to claim 1, which is characterized in that the cryogenic temperature of the cooling piece can
To 14 DEG C ± 2 DEG C.
6. a kind of constant-temperature control method, this method based on a kind of temperature control equipment described in claim 1-5 any one,
Characterized by comprising the following steps:
S1MCU unit sends temperature control according to pre-set heating, refrigeration and temperature control process parameter, to sample bit, reagent position
Order；
S2 is used for the first resistive heater, the second resistive heater heated on sample bit and the refrigeration of reagent position heating
Piece is according to the various progress unit warming operations of the order received, refrigerating operation；
The temperature signal monitored is transferred to chip NE5532 by S3 temperature sensor, and sensor signal is believed by chip NE5532
After number amplifier, it is transferred to MCU unit；
S4MCU unit carries out the analysis of analog signal A/D translation operation, calculates between current temperature value and the target temperature of setting
Relationship controls the first resistive heater and the second resistive heater, if current temperature value is higher than the temperature of setting, leads to
The heater that the first resistive heater and the second resistive heater are closed in the control of MCU unit is crossed, if current temperature value is than setting
Temperature is low, and the heater for opening the first resistive heater and the second resistive heater is controlled by MCU unit；
Temperature controlled implementing result is transferred to MCU unit by S5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610177272.8A CN105676907B (en) | 2016-03-25 | 2016-03-25 | A kind of temperature control equipment and constant-temperature control method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610177272.8A CN105676907B (en) | 2016-03-25 | 2016-03-25 | A kind of temperature control equipment and constant-temperature control method |
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| Publication Number | Publication Date |
|---|---|
| CN105676907A CN105676907A (en) | 2016-06-15 |
| CN105676907B true CN105676907B (en) | 2018-12-28 |
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|---|---|---|---|
| CN201610177272.8A Active CN105676907B (en) | 2016-03-25 | 2016-03-25 | A kind of temperature control equipment and constant-temperature control method |
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| Country | Link |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2508323A1 (en) * | 2002-12-20 | 2004-07-08 | Dakocytomation Denmark A/S | Method and apparatus for pretreatment of biological samples |
| CN202351248U (en) * | 2011-12-14 | 2012-07-25 | 北京众驰伟业科技发展有限公司 | Rotary-sample-feeding type full-automatic coagulation tester |
| CN105092868A (en) * | 2015-09-12 | 2015-11-25 | 丁鸿 | Rotary type integrated structure for sample and reagent positions by coagulation analyzer |
| CN105301264A (en) * | 2015-09-12 | 2016-02-03 | 丁鸿 | Full-automatic coagulation analyzer equipment and detection method |
| CN205581681U (en) * | 2016-03-25 | 2016-09-14 | 丁鸿 | Temperature control device |
-
2016
- 2016-03-25 CN CN201610177272.8A patent/CN105676907B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2508323A1 (en) * | 2002-12-20 | 2004-07-08 | Dakocytomation Denmark A/S | Method and apparatus for pretreatment of biological samples |
| CN202351248U (en) * | 2011-12-14 | 2012-07-25 | 北京众驰伟业科技发展有限公司 | Rotary-sample-feeding type full-automatic coagulation tester |
| CN105092868A (en) * | 2015-09-12 | 2015-11-25 | 丁鸿 | Rotary type integrated structure for sample and reagent positions by coagulation analyzer |
| CN105301264A (en) * | 2015-09-12 | 2016-02-03 | 丁鸿 | Full-automatic coagulation analyzer equipment and detection method |
| CN205581681U (en) * | 2016-03-25 | 2016-09-14 | 丁鸿 | Temperature control device |
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| Publication number | Publication date |
|---|---|
| CN105676907A (en) | 2016-06-15 |
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Effective date of registration: 20190731 Address after: 215500 No. 1, Jindu Road, Changshu High-tech Industrial Development Zone, Suzhou City, Jiangsu Province Patentee after: Jiangsu Hong'en Medical Devices Co. Address before: 215557 No. 1 Jindu Road, Technology Development Zone, Changshu High-tech Production Zone, Suzhou City, Jiangsu Province Patentee before: Ding Hong |
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