CN105669743B - Method for preparing phosphinic acid/phosphonous acid/phosphate from P (O) -OH compound and arylboronic acid - Google Patents

Method for preparing phosphinic acid/phosphonous acid/phosphate from P (O) -OH compound and arylboronic acid Download PDF

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CN105669743B
CN105669743B CN201610008869.XA CN201610008869A CN105669743B CN 105669743 B CN105669743 B CN 105669743B CN 201610008869 A CN201610008869 A CN 201610008869A CN 105669743 B CN105669743 B CN 105669743B
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唐课文
熊碧权
张盼良
许卫凤
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Hunan Institute of Science and Technology
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
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Abstract

The invention provides a method for synthesizing phosphinate/phosphonite/phosphate derivatives containing different substituted functional groups at high selectivity, which adopts metal salt as a catalyst, P (O) -OH compounds and arylboronic acid as reaction substrates, and alkali, additives and organic solvents are added into a reaction system. The method has the advantages that: the catalyst is cheap and easy to obtain; the reaction condition is mild, safe and reliable; the selectivity of the obtained target product is close to 100 percent, and the yield is up to more than 90 percent. The method overcomes the defects of poor reaction selectivity, complicated reaction steps, low yield, the need of using reagents harmful to the environment and the like in the traditional method for synthesizing the phosphinic acid/phosphonous acid/phosphate compounds, and has good industrial application prospect. The invention also provides corresponding phosphinic acid/phosphonous acid/phosphate derivatives containing different substituted functional groups.

Description

Method for preparing phosphinic acid/phosphonous acid/phosphate from P (O) -OH compound and arylboronic acid
Technical Field
The invention relates to the field of application catalytic synthesis of organic phosphonate compounds, in particular to a method for preparing phosphinic acid/phosphonous acid/phosphate derivatives from P (O) -OH compounds and arylboronic acid.
Background
The compounds such as organic phosphinate, phosphonite, phosphate and the like and derivatives thereof are important organic compounds, and the compounds have specific biological activity and good catalytic activity and optical activity, so that the compounds have wide application in the aspects of biology, medicine, optical active materials, asymmetric catalytic synthesis and the like. It is known that it is difficult to find pure natural organic phosphinic acid/phosphate compounds in nature, and phosphorus is mostly present in nature in the form of inorganic salts (> 70%). The organic phosphinic acid/phosphonous acid/phosphate compounds and derivatives thereof which are known at present are mostly synthesized by chemical methods.
In recent years, with the expanding application field of organic phosphinic acid/phosphonous acid/phosphate (especially as organic ligand and ribonucleic acid derivative), the market demand is increasing. Therefore, the development of the synthetic technology of the compounds is also receiving more and more attention. The synthesis method of organic phosphinic acid/phosphonous acid/phosphate compounds reported in the literature at present mainly comprises Michaelis-Arbuzov reaction (by using P (OR))3Substitution rearrangement reaction of trivalent phosphate compound and halogenated aliphatic hydrocarbon), Atherton-Todd reaction (cross coupling reaction of P (O) -H bond-containing compound and nucleophilic reagent (alcohol, phenolic compound and the like) is catalyzed by halogenating reagent such as carbon tetrachloride under the condition), or P (O) -OH compound and sulfonyl chloride are reacted to prepare corresponding P (O) -Cl-containing compound, and then cross coupling reaction is carried out on the compound and nucleophilic reagent (alcohol, phenolic compound and the like)And preparing the corresponding organic phosphinic acid/phosphonous acid/phosphate compound. However, these methods generally employ air-sensitive reagents (P (OR))3Carbon tetrachloride, sulfonyl chloride, etc.), and the experimental procedures are complicated, the reaction conditions are harsh, the yield is low, and the pollution to the environment is large.
So far, the synthesis of organic phosphinic acid/phosphate has the problems of raw material quality, production safety, product stability and purity and the like, the synthesis technology is difficult, only several companies in the countries of America, Japan and the like are in production at present, and China mainly depends on import in the aspects of synthesis, utilization and the like of fine organic phosphonate at present.
Aiming at the defects of the existing organic phosphinic acid/phosphonous acid/phosphate synthesis process, the industry is focusing on developing a method for efficiently and selectively synthesizing the corresponding organic phosphinic acid/phosphonous acid/phosphate compound by using a stable, cheap and easily obtained P (O) -OH-containing compound as a raw material.
[ summary of the invention ]
The invention aims to provide a method for synthesizing corresponding organic phosphinate, phosphate compounds and derivatives thereof with high efficiency and high selectivity by using cheap and easily-obtained compounds containing P (O) -OH as raw materials so as to overcome the defects in the prior art.
The invention provides a method for synthesizing corresponding organic phosphinate, phosphonite, phosphate compounds and derivatives thereof from cheap and easily-available P (O) -OH-containing compounds and arylboronic acid with high efficiency and high selectivity, which comprises the following steps: taking reaction amount of compound containing P (O) -OH, arylboronic acid, catalyst, additive, alkali and organic solvent in O2Or placing the mixture in a reaction container in the air atmosphere for mixing, and reacting for 0.5-10 hours at 25-120 ℃ under stirring to obtain the corresponding phosphinates, phosphinates and phosphate derivatives containing different substituted functional groups. The specific reaction formula is as follows:
Figure DEST_PATH_IMAGE001
wherein Ar is selected from phenyl, 4-methyl-phenyl, 4-fluoro-phenyl, 4-bromo-phenyl, 4-methoxy-phenyl, 2-pyridyl, 4-phenyl, 1-naphthyl, 4-trifluoromethyl-phenyl;
R1is phenyl, phenoxy, butoxy, 2-ethyl-hexyl, 2-ethyl-hexyloxy, 4-methylphenyl, 4-trifluoromethylphenyl;
R2is phenyl, phenoxy, butoxy, 2-ethyl-hexyloxy, 4-methylphenyl, 4-trifluoromethylphenyl.
In the above method for synthesizing the organic phosphinic acid/phosphonous acid/phosphate compound, the base in the reaction step is one or more selected from triethylamine, sodium bicarbonate, potassium carbonate, sodium carbonate, urea, thiourea, cesium carbonate or potassium phosphate.
In the above method for synthesizing the organic phosphinic acid/phosphate compound, the P (O) -OH-containing compound is diphenyl phosphoric acid, diisooctyl phosphate, 2-ethylhexyl phosphate mono-2-ethylhexyl ester, dibutyl phosphate, diphenyl phosphate, di (4-methyl-phenyl) phosphoric acid or di (4-trifluoromethylphenyl) phosphoric acid.
In the method for synthesizing the organic phosphinic acid/phosphonous acid/phosphate compound, the arylboronic acid refers to phenylboronic acid, 4-methylphenylboronic acid, 4-fluorophenylboronic acid, 4-bromophenylboronic acid, 4-methoxyphenylboronic acid, 2-pyridylboronic acid, 4-phenylphenylboronic acid, 1-naphthylboronic acid and 4-trifluoromethylphenylboronic acid.
In the method for synthesizing the organic phosphinic acid/phosphonous acid/phosphate compound, the organic solvent refers to tetrahydrofuran, diethyl ether, toluene, 1, 4-dioxane, and,N,N-one or more of dimethylformamide, dimethylsulfoxide or acetonitrile.
In the method for synthesizing the organic phosphinic acid/phosphonous acid/phosphate compound, the catalyst refers to one or more of palladium chloride, nickel chloride, palladium acetate, ferric trichloride, cuprous iodide, cuprous bromide, cuprous chloride, cupric bromide, cupric acetate, cuprous oxide or cupric sulfate.
In the method for synthesizing the organic phosphinic acid/phosphonous acid/phosphate compound, the additive refers to one or more of a molecular sieve, phosphorus pentoxide, anhydrous sodium sulfate, anhydrous magnesium sulfate and anhydrous calcium chloride.
In the method for synthesizing the organic phosphinic acid/phosphonous acid/phosphate compound, the molar ratio of the P (O) -OH-containing compound to the arylboronic acid is 1: [1.0 to 1.5] containing P (O) -OH compounds and alkali in a molar ratio of 1: [ 1-5 ] the molar ratio of the P (O) -OH compound to the catalyst is 1: [0.01 to 1 ].
The method for synthesizing the organic phosphinic acid/phosphonous acid/phosphate compound from the compound containing P (O) -OH and the arylboronic acid with high efficiency and high selectivity has mild and easily controlled reaction process. The method is simple and easy to implement while obtaining higher yield and 100 percent selectivity, and the used catalyst is cheap and easy to obtain, is simple to prepare and has good industrial application prospect.
[ detailed description ] embodiments
The invention is further illustrated below with reference to examples of the invention:
first, testing and analyzing
The structural analysis of the reaction products in the following examples of the present invention employed GC/MS (6890N/5973N) gas mass spectrometer equipped with HP-5MS capillary chromatography column (30m × 0.45mm × 0.8.8 μm) manufactured by Agilent, and Bruker Avance-III 500 NMR analyzer manufactured by Bruker, the Agilent GC 7820A gas chromatograph equipped with a hydrogen flame detector, AB-FFAP capillary chromatography column (30m × 0.25.25 mm × 0.25.25 μm) manufactured by Agilent was used for the analysis of selectivity and yield of the target products.
Second, example
Example 1
218 mg (1.0 mmol) of diphenylphosphoric acid, 122 mg (1.0 mmol) of phenylboronic acid, 120mg (2.0mmol) of urea, 100 mg of molecular sieve and 28.7 mg (0.2 mmol) of cuprous bromide were added to a Schlenk tube under an oxygen atmosphere, and 3.0 ml of an organic solvent (tetrahydrofuran, diethyl ether, toluene, 1, 4-dioxane, ethyl acetate,N,N-dimethylformamide, dimethyl sulfoxide, acetonitrile) at 80oThe reaction was stirred for 12 hours at C. Analysis by GC detection in acetonitrile as reaction solventThe coupling reaction was then carried out in a yield of 92%.
Example 2
218 mg (1.0 mmol) of diphenylphosphoric acid, 122 mg (1.0 mmol) of phenylboronic acid, 2.0mmol of a base (triethylamine, sodium bicarbonate, potassium carbonate, sodium carbonate, urea, thiourea, cesium carbonate or potassium phosphate), 100 mg of a molecular sieve and 28.7 mg (0.2 mmol) of cuprous bromide were introduced into a Schlenk tube under oxygen, 3.0 ml of acetonitrile was added under oxygen, and 80 mg (0.2 mmol) of cuprous bromide was added thereto under oxygenoThe reaction was stirred for 12 hours at C. The yield of the coupling reaction was 92% when acetonitrile was used as the reaction solvent, as determined by GC assay.
Example 3
218 mg (1.0 mmol) of diphenylphosphoric acid, 122 mg (1.0 mmol) of phenylboronic acid, 120mg (2.0mmol) of urea, 100 mg of additives (molecular sieve, phosphorus pentoxide, anhydrous sodium sulfate, anhydrous magnesium sulfate, anhydrous calcium chloride) and 28.7 mg (0.2 mmol) of cuprous bromide were added to a Schlenk tube under oxygen atmosphere, 3.0 ml of acetonitrile was added under oxygen atmosphere, and 80 mg (0.2 mmol) of acetonitrile was addedoThe reaction was stirred for 12 hours at C. The yield of the coupling reaction was 92% when acetonitrile was used as the reaction solvent, as determined by GC assay.
Example 5
246 mg (1.0 mmol) of bis (4-methyl-phenyl) phosphoric acid, 122 mg (1.0 mmol) of phenylboronic acid, 120mg (2.0mmol) of urea, 100 mg of molecular sieve and 28.7 mg (0.2 mmol) of cuprous bromide are introduced under oxygen into a Schlenk tube, 3.0 ml of acetonitrile are introduced under oxygen, and 80 ml of acetonitrile are addedoThe reaction was stirred for 12 hours at C. After the reaction is finished, the separation and purification can obtain 89 percent of separation yieldO-phenyl-bis (4-methyl-phenyl) phosphinate. By passing1H、31P and13the product was identified by C NMR.
1H NMR (400 MHz, CDCl3, 25oC, TMS): = 7.74-7.79 (m, 4H; Ar), 7.18-7.26 (m, 8H; Ar), 7.04-7.07 (m, 1H; Ar), 2.37 (s, 6H; -CH3);13C NMR (100 MHz,CDCl3, 25oC, TMS): = 150.0 (d,1 J(C,P) = 8.1 Hz; Ar), 114.8 (d,1 J(C,P) =2.9 Hz; Ar), 130.7 (d,1 J(C,P) = 10.7 Hz; Ar), 128.5 (s; Ar), 128.2 (d,1 J(C,P) = 13.7 Hz; Ar), 127.0 (d,1 J(C,P) = 140.0 Hz; Ar-C-P),123.4 (s; Ar),119.7 (d,1 J(C,P) = 4.8 Hz; Ar), 20.6 (d,1 J(C,P) = 1.2 Hz; -CH3);31P NMR(160 MHz, CDCl3, 25oC): = 31.4.
Example 6
354 mg (1.0 mmol) of bis (4-trifluoromethyl-phenyl) phosphoric acid, 122 mg (1.0 mmol) of phenylboronic acid, 120mg (2.0mmol) of urea, 100 mg of molecular sieve and 28.7 mg (0.2 mmol) of cuprous bromide are introduced under oxygen into a Schlenk tube, 3.0 ml of acetonitrile are introduced under oxygen, 80 ml of acetonitrile are addedoThe reaction was stirred for 12 hours at C. After the reaction is finished, the separation and purification can obtain 82% of separation yieldO-phenyl-bis (4-trifluoromethyl-phenyl) phosphinate. By passing1H、31P and13the product was identified by C NMR.
1HNMR (400 MHz, CDCl3, 25oC, TMS): = 8.01-8.06 (m, 4H; Ar), 7.73-7.76 (m, 4H; Ar), 7.11-7.30 (m, 5H; Ar);13C NMR (100 MHz, CDCl3, 25oC, TMS):= 150.3 (d,1 J(C,P) = 8.2 Hz; Ar), 134.6 (dd,1 J(C,P) = 3.1 Hz,2 J(C,F) =32.8 Hz; Ar), 134.5 (d,1 J(C,P) = 137.7 Hz; Ar-C-P), 132.3 (d,1 J(C,P) =10.6 Hz; Ar), 130.0 (s; Ar), 125.7 (dd,1 J(C,P) = 3.7 Hz,2 J(C,F) = 13.7 Hz;Ar), 125.3 (s; Ar), 123.4 (d,2 J(C,F) = 272.0 Hz; -CF3), 120.5 (d,1 J(C,P) =4.9 Hz; Ar);31P NMR (160 MHz, CDCl3, 25oC): = 26.2.
Example 7
248 mg (1.0 mmol) of diphenyl phosphate, 122 mg (1.0 mmol) of phenylboronic acid, 120mg (2.0mmol) of urea, 100 mg of molecular sieve and 28.7 mg (0.2 mmol) of cuprous bromide are introduced into a Schlenk tube under oxygen atmosphere, and3.0 ml of acetonitrile are added, at 80%oThe reaction was stirred for 12 hours at C. After the reaction is finished, the separation and purification can obtain the product with 65 percent of separation yieldO-triphenyl phosphate. By passing1H、31P and13the product was identified by C NMR.
1H NMR (400 MHz, CDCl3, 25oC, TMS): = 7.32-7.36 (m, 6H; Ar), 7.18-7.25 (m, 9H; Ar);13C NMR (100 MHz, CDCl3, 25oC, TMS): = 150.4 (d,J(C,P) =7.3 Hz; Ar), 129.9 (s; Ar), 125.6 (s; Ar), 120.1 (d,1 J(C,P) = 4.9 Hz; Ar);31P NMR (160 MHz, CDCl3, 25oC): = -16.6.
Example 8
290 mg (1.0 mmol) of diisooctyl phosphate, 122 mg (1.0 mmol) of phenylboronic acid, 120mg (2.0mmol) of urea, 100 mg of molecular sieve and 28.7 mg (0.2 mmol) of cuprous bromide are introduced under oxygen into a Schlenk tube, 3.0 ml of acetonitrile is added under oxygen, 80 ml of acetonitrile is addedoThe reaction was stirred for 12 hours at C. After the reaction is finished, the separation and purification can obtain the product with 73% separation yieldO-phenyl-diisooctyl phosphate. By passing1H、31P and13the product was identified by C NMR.
1H NMR (400 MHz, CDCl3, 25oC, TMS): = 7.27-7.35 (m, 2H; Ar), 7.14-7.23 (m, 3H; Ar), 4.00-4.10 (m, 4H; -OCH2), 1.54-1.59 (m, 2H; -CH), 1.26-1.38(m, 16H; -CH2), 0.85-0.90 (m, 12H; -CH3);13C NMR (100 MHz, CDCl3, 25oC, TMS):= 150.8 (d,1 J(C,P) = 6.7 Hz; Ar), 129.6 (s; Ar), 124.8 (s; Ar), 119.9 (d,1 J(C,P) = 4.9 Hz; Ar), 70.4 (d,1 J(C,P) = 6.6 Hz; -OCH2), 40.0 (d,1 J(C,P)= 7.3 Hz; -CH), 29.8 (s; -CH2), 28.8 (s; -CH2), 23.2 (s; -CH2), 22.9 (s; -CH2), 14.0 (s; -CH3), 10.8 (s; -CH3);31P NMR (160 MHz, CDCl3, 25oC): = -4.89.
Example 9
274 mg (1.0 mmol) of 2-ethylhexyl phosphate mono 2-ethylhexyl ester, 122 mg (1.0 mmol) of phenylboronic acid, 120mg (2.0mmol) of urea, 100 mg of molecular sieve and 28.7 mg (0.2 mmol) of cuprous bromide are introduced under oxygen into a Schlenk tube, 3.0 ml of acetonitrile are added under oxygen, 80 ml of acetonitrile are addedoThe reaction was stirred for 12 hours at C. After the reaction is finished, the separation and purification can obtain the product with 73% separation yieldO-phenyl-diisooctyl phosphate. By passing1H、31P and13the product was identified by C NMR.
1H NMR (400 MHz, CDCl3, 25oC,TMS): = 7.28-7.34 (m, 2H; Ar), 7.12-7.23 (m, 3H; Ar), 3.91-4.09 (m, 2H; -OCH2), 1.83-1.90 (m, 3H; -CH, -CH2),1.25-1.51 (m, 17H; -CH, -CH2), 0.84-0.91 (m, 12H; -CH3);13C NMR (100 MHz,CDCl3, 25oC, TMS): = 150.8 (d,1 J(C,P) = 8.4 Hz; Ar), 129.6 (s; Ar), 124.6(s; Ar), 120.4 (d,1 J(C,P) = 4.3 Hz; Ar), 68.0 (d,1 J(C,P) = 7.5 Hz; Ar),40.1 (d,1 J(C,P) = 4.3 Hz; -CH), 34.1 (d,1 J(C,P) = 4.4 Hz; -CH), 33.5 (d,1 J(C,P) = 8.6 Hz; -CH2), 29.9 (s; -CH2), 29.7 (d,1 J(C,P) = 137.9 Hz; P-CH2),28.8 (d,1 J(C,P) = 2.7 Hz; -CH2), 28.4 (d,1 J(C,P) = 2.5 Hz; -CH2), 26.7 (d,1 J(C,P) = 5.6 Hz; -CH2), 23.3 (s; -CH2), 22.9 (s; -CH2), 22.8 (s; -CH2), 14.1(s; -CH3), 14.0 (s; -CH3), 10.9 (s; -CH3), 10.3 (d,1 J(C,P) = 3.5 Hz; -CH3);31P NMR (160 MHz, CDCl3, 25oC): = 29.6.
Example 10
218 mg (1.0 mmol) of diphenylphosphoric acid, 140 mg (1.0 mmol) of 4-fluoro-phenylboronic acid, 120mg (2.0mmol) of urea, 100 mg of molecular sieves and 28.7 mg (0.2 m)mol) cuprous bromide is added into a Schlenk tube under the oxygen environment, 3.0 ml acetonitrile is added under the oxygen environment, and 80 percentoThe reaction was stirred for 12 hours at C. After the reaction is finished, the separation and purification can obtain 82% of separation yieldO-4-fluoro-phenyl-diphenylphosphinic acid ester. By passing1H、31P and13the product was identified by C NMR.
1H NMR (400 MHz, CDCl3, 25oC, TMS): = 7.86-7.91 (m, 4H; Ar), 7.42-7.48 (m, 6H; Ar), 7.14-7.18 (m, 2H; Ar), 6.86-6.90 (m, 2H; Ar);13C NMR (100MHz, CDCl3, 25oC, TMS): = 159.5 (d,1 J(C,F) = 241.8 Hz; Ar-C-F), 146.7 (dd,1 J(C,P) = 10.5 Hz,2 J(C,F) = 5.6 Hz; Ar), 132.6 (d,1 J(C,P) = 2.4 Hz; Ar),131.8 (d,1 J(C,P) = 10.3 Hz; Ar), 130.7 (d,1 J(C,P) = 137.1 Hz; Ar-C-P),128.7 (d,1 J(C,P) = 13.4 Hz; Ar), 122.2 (dd,1 J(C,P) = 12.7 Hz,2 J(C,F) =3.7 Hz; Ar), 116.2 (d,1 J(C,P) = 23.2 Hz; Ar);31P NMR (160 MHz, CDCl3, 25oC): = 32.2.
Example 11
218 mg (1.0 mmol) of diphenylphosphoric acid, 200 mg (1.0 mmol) of 4-bromo-phenylboronic acid, 120mg (2.0mmol) of urea, 100 mg of molecular sieve and 28.7 mg (0.2 mmol) of cuprous bromide are introduced under oxygen into a Schlenk tube, 3.0 ml of acetonitrile are added under oxygen, 80 ml of acetonitrile are addedoThe reaction was stirred for 12 hours at C. After the reaction is finished, the separation and purification can obtain the product with 86 percent of separation yieldO-4-bromo-phenyl-diphenylphosphinate. By passing1H、31P and13the product was identified by C NMR.
1H NMR (400 MHz, CDCl3, 25oC, TMS): = 7.84-7.90 (m, 4H; Ar), 7.50-7.55 (m, 2H; Ar), 7.45-7.49 (m, 4H; Ar), 7.33-7.36 (m, 2H; Ar), 7.08-7.12 (m,2H; Ar);13C NMR (100 MHz, CDCl3, 25oC, TMS): = 149.9 (d,1 J(C,P) = 8.1 Hz;Ar), 132.6 (s; Ar), 132.5 (s; Ar), 131.7 (d,1 J(C,P) = 10.4 Hz; Ar), 130.5(d,1 J(C,P) = 137.2 Hz; Ar-C-P), 128.6 (d,1 J(C,P) = 13.4 Hz; Ar), 122.5 (d,1 J(C,P) = 4.8 Hz; Ar), 117.5 (s; Ar);31P NMR (160 MHz, CDCl3, 25oC): =32.3.
Example 12
218 mg (1.0 mmol) of diphenylphosphoric acid, 136 mg (1.0 mmol) of 4-methyl-phenylboronic acid, 120mg (2.0mmol) of urea, 100 mg of molecular sieve and 28.7 mg (0.2 mmol) of cuprous bromide are introduced under oxygen into a Schlenk tube, 3.0 ml of acetonitrile are added under oxygen, 80 ml of acetonitrile are addedoThe reaction was stirred for 12 hours at C. After the reaction is finished, the separation and purification can obtain the product with 71 percent of separation yieldO-4-methyl-phenyl-diphenylphosphinate. By passing1H、31P and13CNMR identifies the product.
1H NMR (400 MHz, CDCl3, 25oC, TMS): = 7.86-7.91 (m, 4H; Ar), 7.41-7.46 (m, 6H; Ar), 6.98-7.10 (m, 4H; Ar), 2.20 (s, 3H; -CH3);13C NMR (100 MHz,CDCl3, 25oC, TMS): = 148.6 (d,1 J(C,P) = 8.2 Hz; Ar), 134.1 (d,1 J(C,P) =1.8 Hz; Ar), 132.4 (d,1 J(C,P) = 2.6 Hz; Ar), 131.8 (d,1 J(C,P) = 10.2 Hz;Ar), 131.1 (d,1 J(C,P) = 136.7 Hz; Ar-C-P), 130.1 (s; Ar), 128.5 (d,1 J(C,P)= 13.3 Hz; Ar), 120.4 (d,1 J(C,P) = 4.7 Hz; Ar), 20.7 (s; -CH3);31P NMR (160MHz, CDCl3, 25oC): = 30.19.
Example 13
218 mg (1.0 mmol) of diphenylphosphoric acid, 152 mg (1.0 mmol) of 4-methoxy-phenylboronic acid, 120mg (2.0mmol) of urea, 100 mg of molecular sieve and 28.7 mg (0.2 mmol) of cuprous bromide are introduced under oxygen into a Schlenk tube, 3.0 ml of acetonitrile are added under oxygen, 80 ml of acetonitrile are addedoThe reaction was stirred for 12 hours at C. After the reaction is finished, separation and purification can obtain the product with 78% separation yieldIs/are as followsO-4-methoxy-phenyl-diphenylphosphinate. By passing1H、31P and13the product was identified by C NMR.
1H NMR (400 MHz, CDCl3, 25oC, TMS): = 7.86-7.91 (m, 4H; Ar), 7.38-7.47 (m, 6H; Ar), 7.10-7.12 (m, 2H; Ar), 6.71-6.73 (m, 2H; Ar), 3.64 (s, 3H;-OCH3);13C NMR (100 MHz, CDCl3, 25oC, TMS): = 156.1 (s; Ar), 144.0 (d,1 J(C,P) = 8.2 Hz; Ar), 132.1 (d,1 J(C,P) = 2.4 Hz; Ar), 131.5 (d,1 J(C,P) =10.2 Hz; Ar), 130.7 (d,1 J(C,P) = 137.1 Hz; Ar-C-P), 128.2 (d,1 J(C,P) =13.3 Hz; Ar), 121.3 (d,1 J(C,P) = 4.3 Hz; Ar), 114.3 (s; Ar), 55.1 (d,1 J(C,P) = 4.2 Hz; -OCH3);31P NMR (160 MHz, CDCl3, 25oC): = 31.6.
It can be seen from the above examples that the method for synthesizing corresponding phosphinic acid/phosphonous acid/phosphate ester derivatives containing different substituted functional groups by using the compound containing p (o) -OH and arylboronic acid adopted by the invention has the advantages of mild reaction conditions, cheap and easily available catalyst, simple preparation and the like. In addition, the method has the advantages of wide substrate applicability, high yield, high selectivity (100%) and the like, and provides a method for efficiently synthesizing phosphinic acid/phosphonite/phosphate derivatives containing different substituted functional groups.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (7)

1. Reaction type（I）Process for preparing derivatives of phosphinic acid, phosphonous acid and phosphoric acid estersThe preparation method comprises the steps of (1) preparing,
Figure 158271DEST_PATH_IMAGE001
（I）
the method is characterized by comprising the following steps:
taking reaction amount of P (O) -OH compound, Ar-B (OH)2Copper catalyst, molecular sieve, alkali and organic solvent in O2Or placing the mixture in a reaction container in the air atmosphere for mixing, and reacting for 0.5-10 hours at 25-120 ℃ under stirring to obtain the corresponding phosphinic acid, phosphonous acid and phosphate derivative;
wherein the content of the first and second substances,
ar is selected from phenyl, 4-methyl-phenyl, 4-fluoro-phenyl, 4-bromo-phenyl, 4-methoxy-phenyl, 2-pyridyl, 4-phenyl, 1-naphthyl, 4-trifluoromethyl-phenyl;
R1is phenyl, phenoxy, butoxy, 2-ethyl-hexyl, 2-ethyl-hexyloxy, 4-methylphenyl, 4-trifluoromethylphenyl;
R2is phenyl, phenoxy, butoxy, 2-ethyl-hexyloxy, 4-methylphenyl, 4-trifluoromethylphenyl;
the copper catalyst is selected from cuprous iodide, cuprous bromide and cuprous chloride;
the alkali is urea.
2. The method according to claim 1, wherein the P- (O) -OH-containing compound is selected from diphenyl phosphoric acid, mono-2-ethylhexyl 2-phosphate, dibutyl phosphate, diphenyl phosphate, di (4-methyl-phenyl) phosphoric acid, di (4-trifluoromethylphenyl) phosphoric acid.
3. The method according to claim 1, wherein Ar-B (OH)2Is selected from phenylboronic acid, 4-methylphenylboronic acid, 4-fluorophenylboronic acid, 4-bromobenzylboronic acid, 4-methoxyphenylboronic acid, 2-pyridylboronic acid, 4-phenylphenylboronic acid, 1-naphthylboronic acid and 4-trifluoromethylphenylboronic acid.
4. The method according to claim 1, wherein the organic solvent is tetrahydrofuran, diethyl ether, toluene, 1, 4-dioxane, or the like,N,N-dimethylformamide, dimethylsulfoxide or acetonitrile.
5. The method according to claim 1, wherein the P- (O) -OH-containing compound is reacted with Ar-B (OH)2In a molar ratio of 1: [1.0 to 1.5]]。
6. The method according to claim 1, wherein the molar ratio of the P- (O) -OH-containing compound to the base is 1: [1 to 5 ].
7. The preparation method according to claim 1, wherein the molar ratio of the P (O) -OH-containing compound to the catalyst is 1: [0.01 to 1 ].
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CN103980306A (en) * 2014-04-28 2014-08-13 湖南大学 Preparation method for hypophosphorous acid / phosphorous acid/ phosphate compounds by adopting P(O)-OH-contained compounds

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US5861525A (en) * 1996-12-30 1999-01-19 Monsanto Company Method for preparing cyanophosphonate derivatives from phosphate esters and cyanide
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