CN105664278B - With the single blood sampling ingredient rotating cylinder for improving vibration performance - Google Patents
With the single blood sampling ingredient rotating cylinder for improving vibration performance Download PDFInfo
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- CN105664278B CN105664278B CN201610195897.7A CN201610195897A CN105664278B CN 105664278 B CN105664278 B CN 105664278B CN 201610195897 A CN201610195897 A CN 201610195897A CN 105664278 B CN105664278 B CN 105664278B
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- 238000010241 blood sampling Methods 0.000 title description 10
- 239000004615 ingredient Substances 0.000 title description 6
- 210000004369 blood Anatomy 0.000 claims abstract description 108
- 239000008280 blood Substances 0.000 claims abstract description 108
- 238000013016 damping Methods 0.000 claims abstract description 33
- 239000012530 fluid Substances 0.000 claims abstract description 20
- 230000008676 import Effects 0.000 claims abstract description 14
- 238000004891 communication Methods 0.000 claims abstract description 12
- 238000005452 bending Methods 0.000 claims description 3
- 239000000306 component Substances 0.000 description 34
- 239000003146 anticoagulant agent Substances 0.000 description 22
- 229940127219 anticoagulant drug Drugs 0.000 description 22
- 210000002381 plasma Anatomy 0.000 description 20
- 238000000605 extraction Methods 0.000 description 18
- 210000000265 leukocyte Anatomy 0.000 description 12
- 210000001772 blood platelet Anatomy 0.000 description 11
- 238000001990 intravenous administration Methods 0.000 description 9
- 210000003743 erythrocyte Anatomy 0.000 description 7
- 230000008859 change Effects 0.000 description 4
- 238000005054 agglomeration Methods 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 210000003462 vein Anatomy 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 125000002837 carbocyclic group Chemical group 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 230000000644 propagated effect Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000001194 anti-hemostatic effect Effects 0.000 description 1
- 238000002617 apheresis Methods 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 238000000071 blow moulding Methods 0.000 description 1
- 210000000746 body region Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 210000001792 thromboblast Anatomy 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0415—Plasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0427—Platelets; Thrombocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0429—Red blood cells; Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0439—White blood cells; Leucocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Centrifugal Separators (AREA)
- External Artificial Organs (AREA)
Abstract
This application discloses a kind of for whole blood to be separated into the centrifugal basket of blood constitutent, including：Rotatable basic body, the rotatable basic body has body part and neck portion, and body part defines the inside for receiving whole blood, and rotatable basic body can rotate, so that whole blood is separated into a variety of blood constitutents, body part also has the convex shoulder part extended between body part and neck portion；The internal fluid communication of import, the import and rotatable basic body, the import are arranged to introduce whole blood in rotatable basic body；And at least one damping means, at least one damping means are located on convex shoulder part, and are arranged to reinforce at least part of rotatable basic body, and reduce the vibration of centrifugal basket when centrifugal basket rotates.
Description
This divisional application is to be based on that (its international application no is PCT/US2010/ application No. is 201080071064.0
057820), the applying date is on November 23rd, 2010, entitled " having the single blood sampling ingredient rotating cylinder for improving vibration performance "
Chinese patent application divisional application.
Technical field
The present invention relates to the system and method for single blood sampling ingredient, more particularly to reduce and are detached in blood constitutent
Vibration and noise in device.
Background technology
Single blood sampling ingredient (apheresis) is can to detach and acquire single blood from the whole blood that main body is temporarily extracted out
The process of component.In general, by the needle that is inserted into the vein of main body arm and is inserted into cell separator (such as centrifugal basket) come
Extract whole blood out.Once whole blood to be separated into its various components, one or more components can be just taken out from centrifugal basket.It is remaining
Component can be fed back together with optional compensation fluid to main body, to make up the volume for taking out component.The place for extracting and feeding back
Reason is lasting to be carried out, and until having acquired the desired amount of component, at this moment processing stops.The core feature of single blood sampling component system is
Processed but unwanted component is fed back to donor.The blood constitutent of separation can include for example red blood of such as high-density component
Ball, intermediate density component such as blood platelet or white blood cell and low-density fraction such as blood plasma.
Invention content
According to some embodiments of the present invention, it is a kind of be used for by whole blood be separated into blood constitutent centrifugal basket include can
Rotating body, import and multiple damping means.Rotatable basic body can include body part and neck portion.Body part limits
The inside for receiving whole blood is determined, and rotatable, so that whole blood is separated into a variety of blood constitutents.Import can with it is rotatable
The internal fluid communication of ontology, and be arranged to introduce whole blood in rotatable basic body.Multiple damping means can be around neck portion
Be spaced apart (such as radially), and the vibration of centrifugal basket can be reduced when rotating cylinder rotates.Damping means can be flank
Part, and can be bending or straight.
Centrifugal basket can also include the internal fluid communication of outlet, the outlet and rotating cylinder.Outlet can be used for from from
One or more blood constitutents are taken out in scheming rotating cylinder.In order to enable centrifugal basket can rotate and keep sealing, the centrifugation
Machine rotating cylinder can also have the rotating seal for being attached on rotatable basic body and causing that import is connect with body part.Centrifugal basket
Cylinder can also include core, and the core and inside are coaxial.Core generates whole blood separation between the outer wall of core and the inner wall of rotatable basic body
Region.
According to a further embodiment, centrifugal basket can be included in the convex shoulder extended between neck portion and body part
Point.In such embodiments, damping means can be the thickened areas on convex shoulder part.Thickened areas can be towards rotating cylinder
Rotation axis increase thickness.The increase of thickness can be step.
It is a kind of to include for whole blood to be separated into the blood processing system of blood constitutent according to other embodiment：
Intravenous access device, for extracting whole blood from main body；Blood constitutent separator；It is a kind of or more for being extracted from separator
The device of kind blood constitutent；At least one storage container, for storing at least one blood extracted from blood constitutent separator
Liquid component；And for feeding back residual blood component to the device of main body.Whole blood is separated into more by blood constitutent separator
Kind component, and centrifugal basket can be included.
Centrifugal basket can have body part and neck portion.Body part defines the inside for receiving whole blood,
And it is rotatable, so that whole blood is separated into a variety of blood constitutents.Neck portion has multiple damping means, these damping means are turning
Reduce the vibration of centrifugal basket during cylinder rotation.Multiple damping means can be radially spaced around neck portion, and can be straight
And/or bending rib part.Blood constitutent separator can also include (1) and export, the internal flow of the outlet and rotating cylinder
Connection, and be arranged to take out one or more blood constitutents from centrifugal basket；(2) rotating seal, the rotating seal are attached
It is connected on rotatable basic body, and import is in fluid communication with body part；And/or (3) core, the core and inside are coaxial, and
Whole blood separated region is generated between the outer wall of core and the inner wall of rotatable basic body.
In addition it or also may be selected, damping means can be the thickened areas on convex shoulder part, and the convex shoulder part is in neck
Extend between portion part and body part.Thickened areas can increase thickness, and can be step.Centrifugal basket can also
There is the import with internal fluid communication.
According to other embodiment, a kind of centrifugal basket for being used to whole blood being separated into blood constitutent can include revolving
Turn ontology, import and at least one damping means.Rotatable basic body can have body part, convex shoulder part and neck portion.This
Body portion can limit the inside for receiving whole blood, and can be rotatable, so that whole blood is separated into a variety of blood constitutents.
Convex shoulder part can extend between body part and neck portion.
Import and can be arranged to whole blood introducing rotatable basic body with the internal fluid communication of rotatable basic body
It is interior.At least one damping means can be arranged on convex shoulder part, and can be arranged to reinforce at least the one of rotatable basic body
Part, and when rotating cylinder rotates reduce centrifugal basket vibration.At least one damping means can include multiple rib part
(such as curved ribs component or straight rib part).In addition it or also may be selected, which can include being located at
Thickened areas on convex shoulder part.Thickened areas can increase thickness towards the rotation axis of rotating cylinder.The increase of thickness can be
Step.
Description of the drawings
In the following detailed description and refer to the attached drawing, the preceding feature of the present invention is will be better understood, in attached drawing：
Fig. 1 shows the schematic diagrames of single blood sampling component system according to embodiments of the present invention；
Fig. 2 is schematically illustrated according to embodiments of the present invention for the blood constitutent separation of single blood sampling component system of Fig. 1
The side view of device；
Fig. 3, which schematically illustrates according to embodiments of the present invention, Fig. 2 blood constitutent separator and vibrated when it is rotated, to be led to
Cross its propagation；
Fig. 4 A schematically illustrate the side view of centrifugal basket according to embodiments of the present invention, and which part is with section view table
Show, and with damping means；
Fig. 4 B schematically illustrate the side view of centrifugal basket according to embodiments of the present invention, without rotating seal
With with damping means；
Fig. 4 C schematically illustrate the vertical view of centrifugal basket according to embodiments of the present invention, shown in Fig. 4 B；
Fig. 4 D schematically illustrate the perspective view of centrifugal basket according to embodiments of the present invention, shown in Fig. 4 B；
Fig. 4 E to 4H schematically illustrate the perspective of centrifugal basket according to a further embodiment of the present invention, shown in Fig. 4 A
Figure, the centrifugal basket change the damping means of number；
Fig. 5 A schematically illustrate the perspective view of centrifugal basket according to embodiments of the present invention, which has can
The damping means of choosing；
Fig. 5 B to 5F schematically illustrate the perspective of centrifugal basket according to a further embodiment of the present invention, shown in Fig. 5 A
Figure, the centrifugal basket have the optional damping means of variable number；
Fig. 6 A to 6D schematically illustrate a part for the centrifugal basket according to additional embodiment of the present invention, the centrifugal basket
Cylinder has the damping means of third type.
Specific embodiment
Example embodiments of the present invention provides the system and blood constitutent for carrying out single blood sampling component processing procedure
Separator.In addition, each embodiment of the present invention reduces the visible vibration in some prior art separators and makes an uproar
Sound.For example, the embodiment of the present invention can include one or more damping means.The details of example embodiment is explained below.
As shown in figs. 1 and 2 and as described above, single blood sampling component system 10 according to embodiments of the present invention utilizes extraction
It pumps P1 and whole blood is extracted out from main body by intravenous access device 24.Intravenous access device 24 can be the vein that can enter main body
Any device, including but not limited to fleams.When system 10 extracts whole blood out from main body, blood passes through extraction/feedback
Pipeline 28, and enter blood constitutent separator 11, such as Latham type centrifuges.Blood constitutent separator 11 is by whole blood
It is separated into its constituent component (such as red blood cell, white blood cell, blood plasma and blood platelet).Although Latham types set out above from
Scheming, but other types of split cavity and device can also use, such as and non-limiting, the centrifuge of integral blow molding
Rotating cylinder as described in United States Patent (USP) No.4983156 and 4943273, is incorporated in the present application, as reference.
When system 10 extracts whole blood out from main body, anticoagulant can be introduced into the whole blood of extraction by system 10, so as to
Anti- Hemostatic Oral Liquid in-line condenses in blood constitutent separator 11.Therefore, system 10 can include anticoagulant line
32, which is in fluid communication at one end with anticoagulant source 16 (such as anticoagulant bag), at the other end
It is connect with intravenous access device 24 (or being connect by y shapes connector 30 with extraction/feedback pipeline 28).Anticoagulant pump P3
(anticoagulant line 32 pass through the anticoagulant pump P3) can control flowing of the anticoagulant in anticoagulant line 32 with
And it is introduced into the amount of the anticoagulant in whole blood.Although anticoagulant can be added in arbitrary point in whole blood, preferably anti-freezing
Blood agent is introduced as close to 24 ground of intravenous access device.
Anticoagulant line 32 can also include biofilter F2, and biofilter F2 is prevented in anticoagulant source
16th, any bacterium in anticoagulant or anticoagulant line 32 enters system 10 and/or main body.In addition, anticoagulant tube
Line 32 can include air monitor D3, and air monitor D3 detects presence of the air in anticoagulant.It is managed in system 10
There are problems that bubble may all generate the operation of system 10, and also may be used when bubble enters in blood flow in any part of line
Main body can be harmful to.Therefore, air monitor D3 can be connect with interlock, and the interlock is in the situation for detecting bubble
Under stop in anticoagulant line 32 flowing (such as by stop anticoagulant pump P3 or close in anticoagulant line 32
On valve), so as to prevent bubble from entering main body.
Once the desired amount of anti-agglomeration whole blood is extracted out and is contained in blood constitutent separator 11, blood constitutent from main body
Separator 11 allows for whole blood and is separated into a variety of blood constitutents.For example, blood constitutent separator 11 can detach whole blood
Into first, second, third and (possible) the 4th blood constitutent.More specifically, blood constitutent separator 11 can incite somebody to action complete
Blood is separated into blood plasma, blood platelet, red blood cell and possible white blood cell.
As shown in Figure 2, when using Latham centrifuges, blood constitutent separator 11 includes rotatable 12 He of rotating cylinder
Static outputs and inputs mouthful PT1 and PT2, this output and input mouthful PT1 and PT2 by rotating seal 74 and with inside rotating cylinder
It is in fluid communication.Rotatable rotating cylinder can include：Neck portion 110, the neck portion 110 are connect with rotating seal 74；And
Body part 120, the body part 120 define separator internal capacity (such as rotatable rotating cylinder 12 inside hold
Product).Rotating cylinder 12 (such as body part 120) can have frusto-conical shape.Rotatable rotating cylinder 12 can also include convex shoulder
Points 130, which extends and in connection between neck portion 110 and body part 120.
In addition, some embodiments can have core 72, which occupies the volume coaxial with the inside of rotating cylinder 12, and provide
Separated region between the wall of core 72 and external drum wall 70.Extraction/feedback pipeline 28 and intravenous access device 24 (such as put
Blood needle) and input port PT1 fluid communication.In some embodiments, it is quiet in the case where whole blood will collect first and then supply
Arteries and veins, which enters device 24, to be replaced by whole blood bag (not shown).In such embodiments, extracting pipeline 28 will be so that whole blood bag
It is in fluid communication with input port PT1.
As described above, blood constitutent separator 11 is so that whole blood is separated into its constituent component.Particularly, when rotating cylinder 12
During rotation, it is small that centrifugal force so that the anti-agglomeration whole blood entered in cylinder bottom is separated into red blood cell (RBC), white blood cell (WBC), blood
Plate and blood plasma.The rotation number of rotating cylinder 12 can for example select in the range of 4000 to 6000rpm, usually 4800rpm.Blood
Different piece is separated into according to density of fraction.The component (i.e. RBC 60) of higher density is pushed to the outer wall 70 of rotating cylinder 12, and
Blood plasma 66 compared with low-density is in closer core 72.Leukocytic cream 61 is formed between blood plasma 66 and RBC 60.Leukocytic cream 61
It is made of the transition zone 68 and WBC outer layers 62 of blood platelet internal layer 64, blood platelet and WBC.Blood plasma 66 be from separated region near
The component of nearly outlet opening, be when other anti-agglomeration whole blood enters rotating cylinder 12 by inlet hole PT1 by outlet opening PT2 and from
The first fluid component that rotating cylinder 12 removes.
System 10 can also include optical sensor 21, which can be applied to the convex shoulder part of rotating cylinder 12
On.Optical sensor 21 monitors respectively when each layer blood constitutent gradually and is coaxially advanced from the outer wall 70 of rotating cylinder 12 towards core 72
Layer blood constitutent.Optical sensor 21 may be mounted at such position, locate in the position, it is able to detect that up to particular radius
Leukocytic cream, the step of introducing rotating cylinder 12 from main body/donor draw whole blood and by whole blood can respond the detection and stop.
Once blood is separated into various ingredients by blood constitutent separator 11, one or more components can be from blood
It is taken out in liquid component separating device 11.For example, blood plasma can be taken out to plasma bags 18 or be taken out extremely by pipeline 37 (Fig. 1)
Litter bag (not shown).Also it may be selected, blood plasma, which can be taken out to the blood plasma reservoir on extraction/return line 28, (not to be shown
Go out) or white blood cell (WBC) can be taken out by pipeline 35 to one or more white blood cell bags 22.Some realities of system 10
Weight sensor 33 can be included by applying example, which measures the plasma volume of acquisition.Although being not shown, blood platelet bag 20
It can also include similar weight sensor with white blood cell bag 22.The blood plasma of taking-up can pass through pipeline 40 and recycling afterwards
It pumps P2 and is reintroduced back in blood constitutent separator 11 with increased rate, it is small to extract and send blood will pass through pipeline 39
Plate is to blood platelet bag 20.This processing is known as surge elutriation (surge elutriation).
In some embodiments, system 10 can also include line sensor 14, the line sensor 14 can determine from
Open the fluid type (such as blood plasma, blood platelet, red blood cell etc.) of blood constitutent separator.Particularly, line sensor 14 wraps
It includes：LED, the LED transmitting light pass through the blood constitutent for leaving rotating cylinder 12；And photoelectric detector, the photoelectric detector are worn in light
The light is received after crossing the component.The light quantity received by photoelectric detector is associated with the density of the fluid by pipeline.For example, work as
When blood plasma leaves rotating cylinder 12, line sensor 14 can detect when leaving the blood plasma of rotating cylinder 12 and becoming muddy due to blood platelet
Between (such as leave the fluid of rotating cylinder 12 and change thromboblast from blood plasma).System 10 can recycle the information to stop from rotating cylinder
12 take out blood constitutents such as reboot fluid stream by closing valve V2 and opening valve V3.
Once system takes out required component from blood constitutent separator 11, system 10 remaining component can be fed back to
Main body.System can use extraction/feedback pump P1 come so that component is fed back by extraction/feedback pipeline 28 to main body, and the extraction/
It feeds back pipeline 28 with blood constitutent separator 11 and intravenous access device 24 to be in fluid communication, as described above.Also it may be selected, when being
When system 11 is equipped in this way, system can be fed back component to main body by dedicated feedback pipeline.With anticoagulant line 32
Similar with extraction/feedback pipeline 28, dedicated feedback pipeline can also have dedicated feed back to pump, and feedback pump control fluid stream exists
Feed back direction, rate and the duration in pipeline.In such embodiments, pipeline is fed back also to flow with intravenous access device 24
Body connects, preferably at the point fed back between pump and intravenous access device 24.In addition, in such embodiments, system 10
Can also have dedicated extraction pipeline and draw-off pump.In some embodiments, system 10 can include interlock, work as system
When first blood constitutent is fed back to main body, which stops extracting whole blood out from main body.
As shown in fig. 1 and as mentioned briefly above, system 10 can have multiple valves in whole system, to control
The flowing of fluid processed in system 10.For example, extraction/feedback pipeline 28 can include valve V1, valve V1 allows to flow when opening
Pipeline is crossed, prevents from flowing when closed.In addition, the pipeline 35,37 and 39 for respectively leading to white blood cell, blood plasma and blood platelet bag can be with
There are at least one valve V2, V3, V4 and V5 (for example, pipeline 37 has in the valve V2 of the entrance of plasma bags 18 and in plasma bags 18
The valve V5 in exit, and pipeline 39 has the valve V3 in the entrance of blood platelet bag 20).In addition, lead to blood constitutent separator
11 import can have valve (not shown), which allows or prevent from flowing to blood constitutent separator 11 or be detached from blood constitutent
Device 11 flows out.Any of the above-described valve can be manually or automatically.In other words, when meeting specific condition, valve can by user/
Technical staff's manual operation can for example (such as be examined by controller to be automatically brought into operation when in extraction/feedback pipeline 28
Valve V1 is closed when measuring air, as described above).
Similar with anticoagulant line 32, extraction/feedback pipeline 28 also is able to include multiple sensors, filter and detection
Device, to ensure the system operatio of the safety of main body and optimization.Particularly, as shown in fig. 1, extraction/feedback pipeline 28 can
To include air monitor D1 and D2, to detect presence (or do not have) of the air in pipeline 28.Air monitor D1 and
D2 can be connect with interlock, and when detector D1 and D2 detect air, which stops at extraction/feedback pipeline
Flowing (such as pumping P1 or closing valve V1 by stopping extraction/feedback) in 28.In addition, blood mistake can be included by extracting pipeline 28
Filter F1, blood filter F1 remove any bacterium being likely to be present in the blood of extraction or the component of feedback, pollutant
Or particle.
In operation, when 11/ centrifugal basket 12 of separator rotates whole blood being separated into its each group
Timesharing, each component in centrifugal basket 12 may cause centrifugal basket 12 to vibrate.For example, centrifugal basket can include
Two or more rings (such as the carbocyclic ring 112 and ceramics of (such as in rotating seal 74) in the neck portion 110 of rotating cylinder 12
Ring 114, Fig. 4 A).When centrifugal basket 12 rotates, the friction between the contact surface of ring 112/114 can prevent ring
112/114 slides against smooth each other.In this case, the slidingsurface of a ring (such as carbocyclic ring 112) can be repeatedly
Stickup and the surface sliding against another ring (such as ceramic ring 114).The phenomenon that this " paste and slide ", may centrifuge again
Vibration is generated in the neck portion 110 of machine rotating cylinder 12.
As shown in Figure 3, the vibration generated by above-mentioned " paste and slide " phenomenon can pass through convex shoulder from neck portion 110
Part 130 propagates to body part 120.When vibration reaches body part 120, the vibration of the body part 120 and acoustics are special
Sign is so that it sends out audible noise.Such as one might expect that, audible noise may interfere with main body and operating personnel.In addition, any shake
It is dynamic to represent the unstability in system, it reduces the efficiency of system and influences the overall performance of system.
In order to reduce and/or eliminate above-mentioned vibration and audible noise, some embodiments of the present invention can be included in rotating cylinder
One or more damping means on 12.As more fully described below, the neck of rotating cylinder 12 is strengthened and reinforced to these damping means
Part 110 which in turn reduces the vibration of system, and reduces/eliminates the noise sent out by body part 120.
In one embodiment of the invention, as shown in Fig. 4 A to 4H, damping means can be multiple ribs 140, these ribs
140 are spaced apart around rotating cylinder 12 and extend between neck portion 110 and convex shoulder part 130.Rib 140 reinforces the neck of rotating cylinder 12
Part, and the eigentone of neck portion 110 is effectively increased, while do not increase the intrinsic of body part 120 also and shake
Dynamic frequency.
It is important that, it is noted that by increase neck portion 110 eigentone (such as by by rib 140 come
Reinforce neck portion 110), the intrinsic frequency of the neck portion 110 deviates is produced by the stickup and sliding of the slidingsurface of above-mentioned ring
The frequency of raw vibration.Deviateed by the intrinsic frequency of neck portion 110, the Oscillation Amplitude in neck portion 110 will
Reduce, because will no longer have that resonance (for example, will no more be in neck portion by " paste and slide " vibration caused by phenomenon here
Divide 110 intrinsic vibration/resonant frequency).
As described above, the Vibration propagation in neck portion 110 is to body part 120, so that body part 120 shakes
Move and send out audible noise.But, by reducing the Oscillation Amplitude in neck portion 110, shaking for body part 120 is propagated to
It is dynamic equally to reduce so that it is less than the resonant frequency (such as eigentone) of body part 120.It is propagated to by reducing
The vibration (the such as less than resonant frequency of body part 120) of body part 120, will be big by the noise that body part 120 is sent out
It is big to reduce and/or eliminate.
Although Fig. 4 A to 4D illustrate 8 straight ribs (such as in neck portion 110) that the interval between diameters around rotating cylinder 12 are opened,
But as shown in Fig. 4 E-4H, rotating cylinder 12 may include more or less than 8 rib part.For example, rotating cylinder can include it is fewer than 8
Rib part 140 (such as 7 rib part 140, as shown in figure 4e) or (such as 9 flanks of rib part 140 more than 8
Part 140, as shown in figure 4g or 16 rib part 140, as shown in fig. 4h).
Moreover, rib part is not needed to be straight, can there are optional structure and/or shape.For example, as in Fig. 5 A to 5F
Shown, some embodiments of the present invention can include curved ribs component 150, which is spaced around neck portion 110
It opens, and convex shoulder part 130 is extended to from neck portion 110.It is similar with straight rib part 140, curved ribs component 150 also strengthen and
Neck portion 110 is reinforced, to reduce and/or eliminate vibration/noise (such as the intrinsic vibration by increasing neck portion 110
Frequency).In addition, also similar with straight rib part 140, the embodiment with curved ribs component 150 can include any number of
Curved ribs 150.For example, rotating cylinder 12 can include 8 rib part 150 (Fig. 5 A, 5C, 5D), the rib part 150 fewer than 8 (figure
Rib part 150 (Fig. 5 E and 5F) 5B) or more than 8.
Although damping means are introduced above as rib (such as straight rib 140 or curved ribs 150), in other embodiments
In, damping means can be the increase thickness area on the convex shoulder 130 of rotating cylinder 12, Fig. 6 A-D.For example, damping means can be increased
Add thickness 160 single region (such as shown in FIG) or can be the region for increasing thickness.With increase thickness
Region embodiment in, thickness can be stepped up or it can be on one or more steps 160/162/164/166
Face increases (such as shown in Fig. 6 B-6D).It is similar with above-mentioned straight and curved ribs 140/150, thickened areas 160/162/
164/166 increases the strength and stiffness of neck portion 110, to increase the eigentone of neck 110, and reduces/disappears
Vibration propagation except vibration and/or to body part 120.
It is important that it must be noted that the increase for making to be provided by damping means (such as rib 140/150 and/or thickened areas 160)
The advantages of strength and stiffness, balances the impost for being added in the damping means on centrifugal basket 12.Particularly, work as centrifuge
During the weight increase of rotating cylinder 12, the eigentone of body part 120 can change.When the intrinsic vibration of body part 120
When frequency changes, (such as increase strength and stiffness of neck portion) may subtract the advantages of the reduction vibration/noise of damping means
It is small.If for example, the eigentone of body part 120 be changing into so that it and propagate to the reduction of the body part 120
The frequency of vibration is consistent (such as the new resonant frequency of vibration in body part 120), then the body part 120 still may
There is larger vibration and send out audible noise.Therefore, the thickness of the rib part 140/150 in neck portion 110 and thickened areas 160
Degree is necessary in this way, i.e. they will not be so that the weight of centrifuge apparatus be increased sufficiently to substantially change/increase body part 120
Eigentone.
The embodiments of the present invention will be only exemplary；It should be apparent to those skilled in the art that a variety of changes and modifications.
All these changes and modifications will be in the scope of the invention determined by accessory claim.
Claims (15)
1. it is a kind of for whole blood to be separated into the centrifugal basket of blood constitutent, including：
Rotatable basic body, the rotatable basic body have body part and neck portion, and body part defines complete for receiving
The inside of blood, rotatable basic body can rotate, so that whole blood is separated into a variety of blood constitutents, body part also has in body part
Divide the convex shoulder part extended between neck portion；
The internal fluid communication of import, the import and rotatable basic body, the import are arranged to that whole blood introducing can be revolved
Turn in ontology；And
At least one damping means, at least one damping means are located on convex shoulder part, and are arranged to reinforce rotatable
At least part of body and eigentone of the eigentone without increase body part for increasing neck portion, so as to
Reduce the vibration of centrifugal basket when centrifugal basket rotates.
2. centrifugal basket according to claim 1, wherein：At least one damping means include multiple rib part.
3. centrifugal basket according to claim 2, wherein：The rib part is bending.
4. centrifugal basket according to claim 2, wherein：The rib part is straight.
5. centrifugal basket according to claim 1, wherein：At least one damping means include being located at convex shoulder part
On thickened areas.
6. centrifugal basket according to claim 5, wherein：The thickness of thickened areas is towards the rotary shaft of centrifugal basket
Line increases.
7. centrifugal basket according to claim 6, wherein：The increase of thickness is step.
8. centrifugal basket according to claim 7, wherein：Thickness increases on one or more steps.
9. centrifugal basket according to claim 6, wherein：The increase of thickness is gradually.
10. centrifugal basket according to claim 6, wherein：The increase of the thickness includes at least one step.
11. centrifugal basket according to claim 6, wherein：The increase of the thickness includes at least two steps.
12. centrifugal basket according to claim 6, wherein：The increase of the thickness includes at least three steps.
13. centrifugal basket according to claim 6, wherein：The increase of the thickness includes at least four steps.
14. centrifugal basket according to claim 1, wherein：Rotatable basic body is conical butt.
15. centrifugal basket according to claim 5, wherein：The thickened areas is located on the top surface of convex shoulder part
And between body part and neck portion.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610195897.7A CN105664278B (en) | 2010-11-23 | 2010-11-23 | With the single blood sampling ingredient rotating cylinder for improving vibration performance |
| HK16110111.5A HK1221924A1 (en) | 2010-11-23 | 2014-03-18 | Apheresis bowl with improved vibration characteristics |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201080071064.0A CN103313797B (en) | 2010-11-23 | 2010-11-23 | There is the single blood sampling composition rotating cylinder improving vibration performance |
| CN201610195897.7A CN105664278B (en) | 2010-11-23 | 2010-11-23 | With the single blood sampling ingredient rotating cylinder for improving vibration performance |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080071064.0A Division CN103313797B (en) | 2010-11-23 | 2010-11-23 | There is the single blood sampling composition rotating cylinder improving vibration performance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105664278A CN105664278A (en) | 2016-06-15 |
| CN105664278B true CN105664278B (en) | 2018-06-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610195897.7A Active CN105664278B (en) | 2010-11-23 | 2010-11-23 | With the single blood sampling ingredient rotating cylinder for improving vibration performance |
Country Status (2)
| Country | Link |
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| CN (1) | CN105664278B (en) |
| HK (1) | HK1221924A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106111356B (en) * | 2016-06-29 | 2019-03-19 | 四川南格尔生物科技有限公司 | A kind of detection device and detection method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4140268A (en) * | 1977-03-15 | 1979-02-20 | Haemo-Transfer S.A. | Centrifugating device for biological liquids, having a rotatable container, and supporting bracket therefor |
| US4300717A (en) * | 1979-04-02 | 1981-11-17 | Haemonetics Corporation | Rotary centrifuge seal |
| CN2404592Y (en) * | 1999-12-08 | 2000-11-08 | 郝力 | Liquid sealing centrifugical bowl |
| CN2492231Y (en) * | 2000-11-20 | 2002-05-22 | 北京京精医疗设备有限公司 | Autoblood recovering machine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006247217A (en) * | 2005-03-11 | 2006-09-21 | Terumo Corp | Centrifugal separator |
| WO2009131659A1 (en) * | 2008-04-22 | 2009-10-29 | Boston Technology Consultants Group, Inc. | Single use centrifuge system |
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2010
- 2010-11-23 CN CN201610195897.7A patent/CN105664278B/en active Active
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2014
- 2014-03-18 HK HK16110111.5A patent/HK1221924A1/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4140268A (en) * | 1977-03-15 | 1979-02-20 | Haemo-Transfer S.A. | Centrifugating device for biological liquids, having a rotatable container, and supporting bracket therefor |
| US4300717A (en) * | 1979-04-02 | 1981-11-17 | Haemonetics Corporation | Rotary centrifuge seal |
| CN2404592Y (en) * | 1999-12-08 | 2000-11-08 | 郝力 | Liquid sealing centrifugical bowl |
| CN2492231Y (en) * | 2000-11-20 | 2002-05-22 | 北京京精医疗设备有限公司 | Autoblood recovering machine |
Also Published As
| Publication number | Publication date |
|---|---|
| HK1221924A1 (en) | 2017-06-16 |
| CN105664278A (en) | 2016-06-15 |
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