CN105654426A - Pathological section display method and device - Google Patents
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- 239000012634 fragment Substances 0.000 claims abstract description 130
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- G06T3/00—Geometric image transformations in the plane of the image
- G06T3/40—Scaling of whole images or parts thereof, e.g. expanding or contracting
- G06T3/4038—Image mosaicing, e.g. composing plane images from plane sub-images
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Abstract
The invention provides a pathological section display method and device, and relates to the field of medical treatment. The pathological section display method comprises the steps that the maximum number of layers of multiplying power corresponding to a target image fragment is calculated according to pixel width, pixel height and scanning multiplying power; then the determinant value of the target image fragment is calculated according to the maximum number of layers, the scanning multiplying power of a section, the pixel width and the pixel height; and finally the target image fragment is arranged in the corresponding position of the determinant value according to the display method of the corresponding number of layers of the target image fragment so that the target image fragment is displayed. Other image fragments are displayed according to the same method so that the display task of the whole section image can be completed. The section images of different formats can be displayed according to the method so that the same equipment is enabled to display the section images of different formats and compatibility of the equipment can be enhanced.
Description
Technical field
The present invention relates to medical field, specifically, it relates to pathological section display method and device.
Background technology
Pathologic cutting technique, normally first get a certain size pathological tissues, make pathology slide by histopathology method, afterwards slide is taken, and then make section photo, finally, photo of these being cut into slices decomposes, to form images fragment, when needs show, only need to splice these images fragments, just can form the photo that can directly watch. Wherein, the photo gone out captured by same slide has different burst rate, or perhaps when the size of each images fragment is all identical, the images fragment number of the photo of different resolution is different.
After synthetic image fragment, when needing display image every time, first transfer the images fragment under same resolving power, afterwards, according to the relative position of images fragment, these images fragments are stitched together, and then form a complete image. It thus is seen that when development, image mosaic technology can be related to, also it is the research focus of present image process field for the image mosaic of pathological section.
Owing to also exploring district at multiplying power class figure at present, comparing proven technique at present is also only that map class is correlated with, and the multiplying power class picture for non-map class is also exploring region, and technology is still immature, so can cause the phenomenon joined when carrying out image mosaic by mistake. At present, the method for global optimization generally can be adopted to revise when images fragment splices, and then ensure the integrity of spliced image. The method of this kind of global optimization, in theory comparatively reasonable, but speed and effect aspect are all not good enough.
At present, due to the technique of display of pathological section be all substantially each family can only use each family browse instrument, owing to the principle of work of instrument of browsing and the working machine of each family is shaped with difference, result in the pathological section of a certain family to browse in instrument in other families and cannot read (main problem appears in the splicing of images fragment), or perhaps cannot show normally. As shown in Figure 1, it is a broken figure stream (images fragment), each such broken figure stream is spliced, also just can form a complete section photo.
But when carrying out image mosaic, owing to being difficult to determine the concrete coordinate of certain images fragment (broken figure stream), cause splicing that mistake occurs.
Summary of the invention
The pathological section of different-format it is an object of the invention to provide pathological section display method and device, so that all can show in the same apparatus.
First aspect, embodiments provides pathological section display method, comprising:
According to pixel width, pixel height and scanning multiplying power, calculate the maximum number of plies of the multiplying power corresponding to target image fragment;
Scanning multiplying power according to the maximum number of plies, section, pixel width and pixel height calculate the ranks value of target image fragment;
According to the display mode of the number of plies corresponding to target image fragment, target image fragment is put into position corresponding to ranks value, with target image fragment.
In conjunction with first aspect, embodiments provide the first possible enforcement mode of first aspect, wherein, also comprise: if after target image fragment is put into position corresponding to ranks value, cannot normal target image fragment; Then according to predetermined algorithm, the number of plies corresponding to adjustment aim images fragment, and according to the display mode corresponding to the number of plies after adjustment, target image fragment is put into position corresponding to ranks value, with target image fragment.
In conjunction with first aspect, embodiments provide the 2nd kind of possible enforcement mode of first aspect, wherein, also comprise:
By accesses network platform, obtain picture file, picture file carries multiple images fragment;
Resolve picture file, to obtain pixel width, pixel height and scanning multiplying power.
In conjunction with first aspect, embodiments provide the third possible enforcement mode of first aspect, wherein, also comprise:
Slide is put into pick up camera, and the tissue in slide is taken and resolved, to determine pixel width, pixel height and scanning multiplying power;
The section photo that shooting is obtained and corresponding pixel width, pixel height, scanning multiplying power packing, and it is uploaded to the network platform.
In conjunction with first aspect, embodiments provide the 4th kind of possible enforcement mode of first aspect, wherein, also comprise before the step that section photo shooting obtained and corresponding pixel width, pixel height, scanning multiplying power are packed:
Pixel width, pixel height, scanning multiplying power are encrypted.
In conjunction with first aspect, embodiments provide the 5th kind of possible enforcement mode of first aspect, wherein, pixel width, pixel height, scanning multiplying power be encrypted and comprise:
Different encryption modes is used pixel width, pixel height, scanning multiplying power to be encrypted respectively.
In conjunction with first aspect, embodiments provide the 6th kind of possible enforcement mode of first aspect, wherein, also comprise before the step resolving picture file:
The manner of decryption corresponding with encrypt treatment is used to be decrypted by picture file.
Second aspect, the embodiment of the present invention additionally provides pathological section display unit, comprising:
First calculating module, for according to pixel width, pixel height and scanning multiplying power, calculating the maximum number of plies of the multiplying power corresponding to target image fragment;
2nd calculating module, calculates the ranks value of target image fragment for the scanning multiplying power according to the maximum number of plies, section, pixel width and pixel height;
First display module, for the display mode according to the number of plies corresponding to target image fragment, puts into position corresponding to ranks value by target image fragment, with target image fragment.
In conjunction with second aspect, embodiments provide the first possible enforcement mode of second aspect, wherein, also comprise the 2nd display module, if after target image fragment is put into position corresponding to ranks value, cannot normal target image fragment; Then for according to predetermined algorithm, the number of plies corresponding to adjustment aim images fragment, and according to the display mode corresponding to the number of plies after adjustment, target image fragment is put into position corresponding to ranks value, with target image fragment.
In conjunction with second aspect, embodiments provide the first possible enforcement mode of second aspect, wherein, also comprise:
Communication module, for by accesses network platform, obtaining picture file, carry multiple images fragment in picture file;
Parsing module, for resolving picture file, to obtain pixel width, pixel height and scanning multiplying power.
The pathological section display method method that the embodiment of the present invention provides, a set of fixing display packing is only used with same display equipment of the prior art, and owing to the form of the section photo of pathological section is different, cause the section photo of different-format cannot carry out display on same display equipment to compare, first it according to pixel width, pixel height and scanning multiplying power, calculate the maximum number of plies of the multiplying power corresponding to target image fragment; The ranks value of target image fragment is calculated again according to the scanning multiplying power of the maximum number of plies, section, pixel width and pixel height; Finally according to the display mode of the number of plies corresponding to target image fragment, target image fragment is put into position corresponding to ranks value, and then target image fragment. According to identical mode, other images fragments are shown, namely complete the display task of whole section photo. The section photo of different-format all can show according to the method so that same equipment can show the section photo of different-format, it is to increase the compatibility of equipment.
For making above-mentioned purpose, the feature and advantage of the present invention become apparent, better embodiment cited below particularly, and coordinate appended accompanying drawing, it is described in detail below.
Accompanying drawing explanation
In order to be illustrated more clearly in the technical scheme of the embodiment of the present invention, it is briefly described to the accompanying drawing used required in embodiment below, it is to be understood that, the following drawings illustrate only some embodiment of the present invention, therefore should not be counted as is the restriction to scope, for those of ordinary skill in the art, under the prerequisite not paying creative work, it is also possible to obtain other relevant accompanying drawings according to these accompanying drawings.
Fig. 1 shows in correlation technique, the schematic diagram of a broken figure stream;
Fig. 2 shows in correlation technique, is made up of the schematic diagram of whole slices photo images fragment;
Fig. 3 shows in correlation technique, the contrast schematic diagram of adjacent two layers section photo;
Fig. 4 shows the basic flow sheet of the pathological section display method that the embodiment of the present invention provides.
Embodiment
Below in conjunction with accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only the present invention's part embodiment, instead of whole embodiments. The assembly of the embodiment of the present invention usually describing in accompanying drawing herein and illustrating can be arranged with various different configuration and design. Therefore, below to the detailed description of the embodiments of the invention provided in the accompanying drawings and the scope of the claimed the present invention of not intended to be limiting, but only represent the selected embodiment of the present invention. Based on embodiments of the invention, other embodiments all that those skilled in the art obtain under the prerequisite not making creative work, all belong to the scope of protection of the invention.
Preserving pathological section for electronic pictures (section photo), being convenient to doctor transfers anywhere or anytime and watches, as when holding a consultation, meeting time, the mode transferred all can be adopted to be shown by pathological section, allow multiple expert watch simultaneously. When preserving pathological section, a case section can not only have a kind of preserving type (mainly referring to the section that can not only preserve a resolving power), this considers that doctor is when observing this case and cut into slices, need to carry out pathological section to amplify, mobile etc. operation, ensure that doctor from different aspects to observe this pathological section, and then can ensure to observe accuracy and the integrity of case section. And, consider when loading complete image on same computer (can also be such as other display devices such as projectors) simultaneously, when resolving power is very high time, complete image can not all be shown by computer screen, and if show the load of computer simultaneously can be bigger. Therefore, when pathological section is made as section photo by making, section photo will be decomposed, to form multiple images fragment, form the form such as Fig. 2, and when display, the image that part images fragment is only spliced into a local, shows over the display. Usually, it is contemplated that the section photo that resolving power is more high, its images fragment is also more many (no matter the section photo of which kind of resolving power, the size presented over the display of single image fragment is all identical). When user amplifies time, section photo higher for resolving power is also just shown by computer over the display.
As shown in Figure 1, each images fragment have row (Y), row (X), layer these three attributes of multiplying power (Z), this is similar to the plane picture that is placed on three-dimensional space, image mosaic be also exactly by same layer the graphics fragments of multiplying power be spliced into the section photo of a certain resolving power, afterwards, in a comparable manner every layer of section is all spliced, also just defined the section photo under different resolution. When splicing, mainly refer to, the images fragment of number of plies phase is stitched together, wherein, main is find the three of corresponding images fragment to be coordinate, after knowing that the three of images fragment are coordinate, also just can be put on the position specified by this images fragment. As shown in Figure 2, the images fragment splicing result of a certain layer is shown, it can be seen that the splicing for a certain layer picture is also exactly be placed into by the images fragment specified on the position specified (specifying on the position of horizontal stroke, ordinate zou). The picture of concrete adjacent two layers have similar relation as shown in Figure 3 (herein in order to two with 9 layers of layer and only 8 layers of one represent the relation of its layer with ranks), can find by figure below, 8 layers is corresponding with 9 layers of four angular coordinate, the multiplying power of 9 layers is 2 times of 8 layers, namely, the actual size corresponding to an images fragment in 8th layer of photo is identical with the actual size corresponding to two images fragments in the 9th layer of photo.
The display form that often kind of section photo all has it intrinsic, the file such as types (different suffix) different in computer needs to use different modes to open. The section photo of a certain type all has its distinctive unfolding mode (stitched together by images fragment and carry out the mode that shows), it is different that the photo of especially each family preserves form, this causes a certain section photo can only open in a certain computer, cannot be opened by other computer (being alternatively that other computers are not known mode that this kind of images fragment stitchs together). This directly results in when photo of cutting into slices is transferred to different hospital, and the hospital receiving section photo cannot normally show these sections photo (fragment of this section photo also cannot be assembled into a complete section photo exactly).
In view of this, this application provides pathological section display method, as shown in Figure 4, comprising:
S101, according to pixel width, pixel height and scanning multiplying power, calculates the maximum number of plies of the multiplying power corresponding to target image fragment;
S102, calculates the ranks value of target image fragment according to the scanning multiplying power of the maximum number of plies, section, pixel width and pixel height;
S103, according to the display mode of the number of plies corresponding to target image fragment, puts into position corresponding to ranks value by target image fragment, with target image fragment.
Wherein, pixel width and pixel height are that the camera taken is affected, and after being completed by the section photograph taking of this tissue, just can determine, pixel width, height pass through machine resolving power coefficients conversion gained for during shooting. This coefficient unit is pixel/um, i.e. the ratio value of pixel and micron. The value that this ratio value carries when being machine shooting. Scanning multiplying power refers to adopt the specification (resolving power of different size has difference) of which kind of scanning to take. Ranks value refers to the position of target image fragment in section photo.
After performing step S101 and step S102, by the display mode of target image fragment according to the corresponding number of plies, images fragment is put on the position corresponding to ranks value, the display of this target image fragment can be completed, afterwards, it is put on corresponding position according to identical mode by other images fragments can to complete the display of whole section photo.
Wherein, when carrying out image slice display, first show single image fragment by step S103, afterwards repeated execution of steps S101-step S103, just can complete the display of whole image slice. Concrete, when whole of display section photo, first images fragment is spliced complete according to the mode of step S101-S103, finally carry control by cs or bs again and show
The process that step S103 performs may occur that image loads failed situation, also it is exactly cannot normal target image fragment. The major cause of this kind of situation is caused to be the problem of multiplying power. Multiplying power such as target image fragment is 10, but adopt multiplying power be 5 mode images fragment is shown, then images fragment can be caused to exceed border. In order to guarantee normally to show image, in the event of cannot the situation of normal target image fragment time, then should the display mode of adjustment aim fragment, concrete adjustment mode is exactly the number of plies (the different numbers of plies correspond to different display modes) redefining target image fragment. Specifically, also it is exactly that the pathological section display method that provides of the application also comprises: if after target image fragment is put into position corresponding to ranks value, cannot normal target image fragment; Then according to predetermined algorithm, the number of plies corresponding to adjustment aim images fragment, and according to the display mode corresponding to the number of plies after adjustment, target image fragment is put into position corresponding to ranks value, with target image fragment.
As shown in following table 1 and table 2, sets forth two kinds of specifications (20 times and 40 times) different number of plies of image slice and the conversion relation of multiplying power:
Table 1,20 times:
| Multiplying power | The shown number of plies | The power of 2 |
| 20 | 16 | 0 |
| 10 | 15 | 1 |
| 5 | 14 | 2 |
| 2.5 | 13 | 3 |
| 1.25 | 12 | 4 |
| 0.625 | 11 | 5 |
| 0.3125 | 10 | 6 |
| 0.15625 | 9 | 7 |
| 0.078125 | 8 | 8 |
| 0.0390625 | 7 | 9 |
Table 2,40 times:
As seen from the above table, if 8 layers is 1 picture, then the picture of 9 layers (multiplying power correspondences 0.15625) vertically spreads according to pyramid form, and picture number is then 2-4. The ratio of the picture number of adjacent two layers all with above-mentioned 8,9 layers similar.
In step S103, according to the display mode of the number of plies corresponding to described target image fragment, also it is exactly show according to the mode corresponding to the number of plies different in table 1 or table 2 or different multiplying, the display mode of the different numbers of plies or different multiplying powers is different, therefore, when images fragment carries out showing according to the mode of the number of plies/multiplying power of mistake time, just there will be the situation that display is failed. As shown in table 1, in the section photo of 20 times, multiplying power is 20 is that your display mode of the images fragment corresponding to 16 is identical with the number of plies, similar, multiplying power is 5 is that your display mode of the images fragment corresponding to 14 is identical with the number of plies, and multiplying power is 0.078125 is that your display mode of the images fragment corresponding to 8 is identical with the number of plies.
Concrete, it is possible in the following manner images fragment and relevant data are stored into the network platform and from the network platform, obtain images fragment and relevant data.
The pathological section display method that the application provides, also comprises:
By accesses network platform, obtain picture file, picture file carries multiple images fragment;
Resolve picture file, to obtain pixel width, pixel height and scanning multiplying power.
Further, the pathological section display method that the application provides, also comprises the steps:
11, slide is put into pick up camera, and the tissue in slide is taken and resolved, to determine pixel width, pixel height and scanning multiplying power;
12, the section photo that shooting is obtained and corresponding pixel width, pixel height, scanning multiplying power packing, and it is uploaded to the network platform.
Wherein, the network platform refers to 91360 platforms.
In order to ensure to upload to the security of the data of platform, also comprise before the step that section photo shooting obtained and corresponding pixel width, pixel height, scanning multiplying power are packed:
Pixel width, pixel height, scanning multiplying power are encrypted.
Further, in order to strengthen the security of data, pixel width, pixel height, scanning multiplying power are encrypted and comprise:
Different encryption modes is used pixel width, pixel height, scanning multiplying power to be encrypted respectively.
Corresponding, in method, except the step of encryption, also should include the step of deciphering, also comprise before the step resolving picture file:
The manner of decryption corresponding with encrypt treatment is used to be decrypted by picture file.
Specifically, the process of encrypt treatment can adopt the means of asymmetric encryption. Can be grasp decrypted private key by user (executive of step S101-step S103), encrypted public key is grasped by supplier's executive of 12 (step 11 and), and then supplier is before being uploaded to the network platform by images fragment and correlation parameter (pixel width, pixel height and scanning multiplying power), encrypted public key is first used to be encrypted, afterwards, user re-uses decrypted private key after getting correlation parameter by the network platform and processes, and then ensure that the security of parameter.
Provide a concrete example below so that the pathological section display method that the application provides to be described,
1, it is known that the picture of minimum a layer of 20 times will be transferred;
By scheming upper list 1: minimum one layer (7 layers) only a pictures multiplying power be 0.0390625;
2, ask multiplying power be 0.0390625 or the number of plies be 7 the first row first row picture;
3, finally import gained parameter into algorithm bottom and can obtain tile stream.
Corresponding with pathological section display method, the embodiment of the present invention additionally provides pathological section display unit, comprising:
First calculating module, for according to pixel width, pixel height and scanning multiplying power, calculating the maximum number of plies of the multiplying power corresponding to target image fragment;
2nd calculating module, calculates the ranks value of target image fragment for the scanning multiplying power according to the maximum number of plies, section, pixel width and pixel height;
First display module, for the display mode according to the number of plies corresponding to target image fragment, puts into position corresponding to ranks value by target image fragment, with target image fragment.
Preferably, this device also comprises the 2nd display module, if after target image fragment is put into position corresponding to ranks value, and cannot normal target image fragment; Then for according to predetermined algorithm, the number of plies corresponding to adjustment aim images fragment, and according to the display mode corresponding to the number of plies after adjustment, target image fragment is put into position corresponding to ranks value, with target image fragment.
Preferably, this device also comprises:
Communication module, for by accesses network platform, obtaining picture file, carry multiple images fragment in picture file;
Parsing module, for resolving picture file, to obtain pixel width, pixel height and scanning multiplying power.
The technician of art can be well understood to, for convenience and simplicity of description, and the concrete working process of the system of foregoing description, device and unit, it is possible to reference to the corresponding process in aforementioned embodiment of the method, do not repeat them here.
If described function realize using the form of software functional unit and as independent production marketing or when using, it is possible to be stored in a computer read/write memory medium. Based on such understanding, the technical scheme of the present invention in essence or says that the part of part or this technical scheme prior art contributed can embody with the form of software product, this computer software product is stored in a storage media, comprise some instructions with so that a computer equipment (can be Personal Computer, server, or the network equipment etc.) perform all or part of step of method described in each embodiment of the present invention. And aforesaid storage media comprises: USB flash disk, portable hard drive, read-only storage (ROM, Read-OnlyMemory), random access memory (RAM, RandomAccessMemory), magnetic disc or CD etc. various can be program code stored medium.
The above; it is only the specific embodiment of the present invention, but protection scope of the present invention is not limited thereto, any it is familiar with those skilled in the art in the technical scope that the present invention discloses; change can be expected easily or replace, all should be encompassed within protection scope of the present invention. Therefore, protection scope of the present invention should described be as the criterion with the protection domain of claim.
Claims (10)
1. pathological section display method, it is characterised in that, comprising:
According to pixel width, pixel height and scanning multiplying power, calculate the maximum number of plies of the multiplying power corresponding to target image fragment;
Scanning multiplying power according to the maximum number of plies, section, pixel width and pixel height calculate the ranks value of target image fragment;
According to the display mode of the number of plies corresponding to described target image fragment, described target image fragment is put into position corresponding to described ranks value, to show described target image fragment.
2. pathological section display method according to claim 1, it is characterised in that, also comprise: if after described target image fragment is put into position corresponding to described ranks value, cannot normally show described target image fragment; Then according to predetermined algorithm, adjust the number of plies corresponding to described target image fragment, and according to the display mode corresponding to the number of plies after adjustment, described target image fragment is put into position corresponding to described ranks value, to show described target image fragment.
3. pathological section display method according to claim 1, it is characterised in that, also comprise:
By accesses network platform, obtain picture file, described picture file carries multiple images fragment;
Resolve described picture file, to obtain pixel width, pixel height and scanning multiplying power.
4. pathological section display method according to claim 3, it is characterised in that, also comprise:
Slide is put into pick up camera, and the tissue in slide is taken and resolved, to determine pixel width, pixel height and scanning multiplying power;
The section photo that described shooting is obtained and corresponding described pixel width, pixel height, scanning multiplying power packing, and it is uploaded to the network platform.
5. pathological section display method according to claim 4, it is characterised in that, also comprise before the step that the described section photo described shooting obtained and corresponding described pixel width, pixel height, scanning multiplying power are packed:
Described pixel width, pixel height, scanning multiplying power are encrypted.
6. pathological section display method according to claim 5, it is characterised in that, described described pixel width, pixel height, scanning multiplying power are encrypted and comprise:
Different encryption modes is used described pixel width, pixel height, scanning multiplying power to be encrypted respectively.
7. pathological section display method according to claim 4, it is characterised in that, also comprise before the step of the described picture file of described parsing:
The manner of decryption corresponding with described encrypt treatment is used to be decrypted by described picture file.
8. pathological section display unit, it is characterised in that, comprising:
First calculating module, for according to pixel width, pixel height and scanning multiplying power, calculating the maximum number of plies of the multiplying power corresponding to target image fragment;
2nd calculating module, calculates the ranks value of target image fragment for the scanning multiplying power according to the maximum number of plies, section, pixel width and pixel height;
First display module, for the display mode according to the number of plies corresponding to described target image fragment, puts into position corresponding to described ranks value by described target image fragment, to show described target image fragment.
9. pathological section display unit according to claim 8, it is characterised in that, also comprise the 2nd display module, if after described target image fragment is put into position corresponding to described ranks value, cannot normally show described target image fragment; Then for according to predetermined algorithm, adjusting the number of plies corresponding to described target image fragment, and according to the display mode corresponding to the number of plies after adjustment, described target image fragment is put into position corresponding to described ranks value, to show described target image fragment.
10. pathological section display unit according to claim 8, it is characterised in that, also comprise:
Communication module, for by accesses network platform, obtaining picture file, carry multiple images fragment in described picture file;
Parsing module, for resolving described picture file, to obtain pixel width, pixel height and scanning multiplying power.
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| CN107220499A (en) * | 2017-05-26 | 2017-09-29 | 粉蓝医疗科技（杭州）有限公司 | Section file memory method and device |
| CN113706556A (en) * | 2021-08-20 | 2021-11-26 | 珠江水利委员会珠江水利科学研究院 | Rapid detection and replacement method for image slice edge fragments |
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