CN105653886A - Device for predicting prostate cancer risk in prostate aspiration biopsy - Google Patents
Device for predicting prostate cancer risk in prostate aspiration biopsy Download PDFInfo
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- CN105653886A CN105653886A CN201610178548.4A CN201610178548A CN105653886A CN 105653886 A CN105653886 A CN 105653886A CN 201610178548 A CN201610178548 A CN 201610178548A CN 105653886 A CN105653886 A CN 105653886A
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
Abstract
The invention discloses a device for predicting a prostate cancer risk in prostate aspiration biopsy. The risk of prostate cancer is predicted in advance, prostate biopsy is only carried out on patients is avoided under the condition that missed diagnosis is not increased, and thus unnecessary biopsy of biopsy patients is reduced. According to the technical scheme, related clinical clinicopathologic data of newly-diagnosed prostate aspiration biopsy patients is subjected to retrospective analysis, a prediction nomographic chart of related prediction indexes is established, and accordingly the device convenient to use clinically is designed. By means of the device, clinical doctors can predict the probability of newly-diagnosed prostate aspiration biopsy cancer according to three clinical indexes, namely, prostate health index numerical values, the prostate volume and the age of patients.
Description
Technical field
The present invention relates to a kind of disease forecasting device, particularly relate to for predicting that first visit prostate biopsy patient suffers from the device of prostate cancer risk.
Background technology
In China in the past during the decade, prostate cancer develops into city Male resident emerging health threat gradually. In the Male resident of Shanghai, the year mark rate of prostate cancer sharply rises to 2009 12.96/10 ten thousand from 5.6/10 ten thousand in 1999, and has become the 5th of the most common male malignancy in Shanghai. Although the rising of prostate-cancer incidence is caused by multiple factor, but in China developed regions by extensively adopting serum prostate specific antigens (PSA) examination that reason wherein can also be partly described. Effecting a radical cure in art patient's document up-to-date about row prostate cancer, wherein the diagnosis of 64.3% patients with prostate cancer does not increase the weight of to raise based on simple PSA level with urinary tract symptom, and only accounts for 10% in the incidence of this kind of situation in 2005.
Chinese male crowd is detected by Serum PSA level and prostate cancer is carried out examination, but the lower especially scope between PSA4-10ng/ml of PSA specificity, the result of puncture is diagnosed as prostate cancer only 19.4%. Compare and western countries crowd (36%-56%), the while that the positive rate of China's prostate biopsy being still low, also illustrate that the incidence of China's unnecessary puncture inspection is higher. Therefore, doctor only relies on the generation that PSA value judges whether to carry out prostate biopsy and obviously can cause excessively puncture in clinical decision-making. In clinical position in order to ensure prostate cancer early discovery reduce simultaneously excessively diagnosis the injury that brings to patient, scientific research personnel has made multiple types of tools to improve the specificity of PSA diagnosis, such as per-cent (%fPSA) and the PSA density (PSAD) of fPSA and tPSA, i.e. the ratio of PSA and prostate volume. Result is not fully up to expectations, %fPSA and PSAD is still lower to the resolving ability of prostate cancer, and area under curve (AUC) is less than 0.656. Therefore, new tumor marker still fails to meet raising further to the specificity of prostate cancer diagnosis in current clinical practice.
PSA hypotype, the most noticeable place of [-2] proPSA (p2PSA) contributes to solving this kind of difficulty. Derivative prostate health index (PHI) of p2PSA obtained U.S. food and Drug Administration (FDA) to the male sex of the horizontal 4-10ng/ml of male sex PSA and rectum touch feminine gender to detect prostate cancer. PHI single factor test predicts the outcome and analyzes its AUC of display is 0.73 be obviously better than using merely tPSA (AUC is 0.53).
Main purpose of the present invention builds based on only one China crowd PHI nomographic chart to set up a kind of instrument predicting prostate cancer incidence. Because the unnecessary aspiration biopsy incidence of China's prostate gland is higher, and currently lacks effective forecasting tool for Chinese population, therefore we refer to examine negative crowd for PSA4-10ng/ml and rectum. The forecasting tool of this prostate cancer can improve the assessment of first prostate biopsy and suffer from cancer risk accuracy, and its assistance application is in clinical practice work.
Summary of the invention
The concise and to the point general introduction below providing one or more aspect is to provide the basic understanding to these aspects. Detailed the combining of this not all aspect contemplated of general introduction is look at, and both not intended to be pointed out out the scope of key or decisive any or all aspect of elements nor delineate of all aspects. Its unique object is the sequence that some concepts being provided one or more aspect in simplified form think the more detailed description provided after a while.
It is an object of the invention to solve the problem, provide a kind of device that aspiration biopsy of prostatic gland suffers from prostate cancer risk of predicting, by predicting the risk of prostate cancer in advance, the patient that just diagnosis suffers from prostate cancer risk high carries out prostate biopsy targetedly, avoid the excessive use of prostate biopsy when not increasing and fail to pinpoint a disease in diagnosis, thus reduce the puncture that puncture patient is unnecessary.
The technical scheme of the present invention is: present invention is disclosed a kind of device that aspiration biopsy of prostatic gland suffers from prostate cancer risk of predicting, described device comprises:
Input unit, receives the age variable of first visit prostate biopsy patient, prostate volume variable and prostate health index (PHI) variable;
Treatment unit, connects described input unit, based on described age variable, described prostate volume variable and described prostate health index variable, obtains the positive rate P of the prostate biopsy of described first visit prostate biopsy patient according to formula, and described formula is:
P=1/{1+exp [-(-11.4391+0.083*Age-0.0103*Volume+0.1096*PHI)] }
Wherein, Age represents described age variable, and PHI represents described prostate health index variable, and Volume represents described prostate volume variable;
Take-off equipment, connects described treatment unit, exports the forecasting risk value that described device finally obtains.
Prediction aspiration biopsy of prostatic gland according to the present invention suffers from an embodiment of the device of prostate cancer risk, and described input unit comprises:
Memory module, is provided with three input slots, and described three input slots are respectively pickup groove, first and chute, the 2nd can be supplied can to supply chute;
Three load modules, described three load modules be respectively be placed in described pickup groove prostate health index load module, be placed on described first can for the prostate volume load module in chute and be placed on the described 2nd can for the age input module in chute, wherein said prostate health index load module is for inputting described prostate health index variable, described prostate volume load module is for inputting described prostate volume variable, and described age input module is for inputting described age variable.
Prediction aspiration biopsy of prostatic gland according to the present invention suffers from an embodiment of the device of prostate cancer risk, and described processing module is used for being adjusted the position of described three load modules in each input slot of described memory module, obtains and exports site.
Prediction aspiration biopsy of prostatic gland according to the present invention suffers from an embodiment of the device of prostate cancer risk, the position adjustment of described processing module is: the site of the described prostate volume variable received by described prostate volume load module is set to the initial point position of described age input module, the terminal of the described age variable described age input module received is set to the initial point position of described prostate health index load module, the terminal site of the described prostate health index variable received by described prostate health index load module is treated to described output site.
Prediction aspiration biopsy of prostatic gland according to the present invention suffers from an embodiment of the device of prostate cancer risk, described output module is provided with the scale of the forecasting risk value of prostate cancer, and the site of described output site correspondence on described scale is the positive rate that first visit aspiration biopsy of prostatic gland suffers from cancer risk.
Present invention further teaches a kind of device that aspiration biopsy of prostatic gland suffers from prostate cancer risk of predicting, it is characterised in that, described device comprises:
Memory module, is provided with three input slots, is respectively pickup groove, first and chute, the 2nd can be supplied can to supply chute;
Three load modules, be respectively be placed in described pickup groove prostate health index (PHI) variable load module, be placed on described first can for the prostate volume load module in chute and be placed on the 2nd can for the age input module in chute, wherein, described prostate health index variable load module is for inputting prostate health index variable, described prostate volume load module is for inputting prostate volume variable, and described age input module is for inputting age variable;
Processing module, for being adjusted the position of described three load modules in each input slot of described memory module, obtains and exports site;
Output module, is provided with the scale of the forecasting risk value of prostate cancer, and the site of described output site correspondence on described scale is the positive rate that first visit aspiration biopsy of prostatic gland suffers from cancer risk.
Prediction aspiration biopsy of prostatic gland according to the present invention suffers from an embodiment of the device of prostate cancer risk, the position adjustment of described processing module is: the site of the described prostate volume variable received by described prostate volume load module is set to the initial point position of described age input module, the terminal of the described age variable described age input module received is set to the initial point position of described prostate health index load module, the terminal site of the described prostate health index variable received by described prostate health index load module is treated to described output site.
The present invention contrasts prior art following useful effect: the present invention based on principle be that the relevant clinical pathological data to first visit aspiration biopsy of prostatic gland patient carries out retrospective analysis, set up the prediction nomographic chart of correlation predictive index, and thus design the device being convenient to Clinical practice. By this device, clinician can measure the probability of first visit prostate biopsy trouble cancer in advance according to prostate health index (PHI) value of patient, prostate volume and age 3 clinical indices. Compared to prior art, the device of the present invention can not be used for clinical on prostate cancer is made a definite diagnosis diagnosis by first visit aspiration biopsy of prostatic gland, but the probability that prostate cancer is suffered from prediction first visit prostate biopsy patient's biopsy can be improved, just the patient that prostate cancer relative risk is high is carried out aspiration biopsy of prostatic gland targetedly, avoid when not increasing and fail to pinpoint a disease in diagnosis patient to the excessive use of aspiration biopsy, thus reach the object of the use of the unnecessary painful minimizing medical resource of patient.
Accompanying drawing explanation
Fig. 1 shows the schematic diagram of the better embodiment of the device of the prediction aspiration biopsy of prostatic gland trouble prostate cancer risk of the present invention.
Fig. 2 shows the schematic diagram of the memory module of the device of the prediction aspiration biopsy of prostatic gland trouble prostate cancer risk of the present invention.
Fig. 3 to 6 shows the schematic diagram of the load module of the device of the prediction aspiration biopsy of prostatic gland trouble prostate cancer risk of the present invention.
Fig. 7 A, 7B show the schematic diagram of the prediction process of the processing module of the device of the prediction aspiration biopsy of prostatic gland trouble prostate cancer risk of the present invention.
Fig. 8 shows another schematic diagram implementing mode of the device of the prediction aspiration biopsy of prostatic gland trouble prostate cancer risk of the present invention.
Fig. 9 shows and looks back the corresponding nomographic chart of model coefficient according to Logistic.
Embodiment
After the detailed description reading embodiment of the present disclosure in conjunction with the following drawings, it is possible to understand the above-mentioned feature and advantage of the present invention better. In the accompanying drawings, each assembly is not necessarily drawn in proportion, and the assembly with similar relevant characteristic or feature may have identical or close Reference numeral.
Fig. 1 shows the principle of the better embodiment of the device of the prediction aspiration biopsy of prostatic gland trouble prostate cancer risk of the present invention. Referring to Fig. 1, the device of the present embodiment comprises: input unit 1, treatment unit 2 and take-off equipment 3.
Input unit 1 receives the age variable of first visit prostate biopsy patient, prostate volume variable and prostate health index (PHI) variable.
Treatment unit 2 connects input unit 1, based on age variable, prostate volume variable and prostate health index variable, the positive rate P of the prostate biopsy of first visit prostate biopsy patient is obtained according to formula, i.e. Logit (P)=In (P/ (1 P)), is specially:
P=1/{1+exp [-(-11.4391+0.083*Age-0.0103*Volume+0.1096*PHI)] }
Wherein, Age represents age variable, and PHI represents prostate health index variable, and Volume represents prostate volume variable.
Take-off equipment 3 connection handling device 2, the forecasting risk value (positive rate P) that take-off equipment finally obtains.
The present invention is the related pathologies data by analyzing first visit prostate biopsy patient, set up Relational database, and the clinical and pathological data variable adopting the multifactor analysis of regression model of Logistic relevant to prostate cancer with R statistical software in a database, and filter out relevant predictive model variable and calculate the model coefficient of predictive variable. Fig. 9 shows the incidence being referred to examine negative prostate cancer by PHI-nomographic chart forecast China crowd PSA��10ng/ml and rectum. The formula of above-mentioned positive rate P is drawn by above-mentioned analysis.
The input unit 1 of the present embodiment is provided with three as shown in Figure 2 input slot, is respectively pickup groove, first and chute, the 2nd can be supplied can to supply chute. In addition, as shown in Fig. 3 to 6, also have three load modules, be respectively be placed in pickup groove prostate health index variable load module, be placed on first can for the prostate volume load module in chute and be placed on the 2nd can for the age input module in chute.
Prostate health index value variable load module is for inputting prostate health index value variable, and prostate volume load module is for inputting prostate volume variable, and age input module is for inputting age variable.
As shown in Fig. 7 A, 7B, processing module is adjusted the position of these three load modules in each input slot of memory module, obtains and exports site. This kind of position adjustment be specifically: Fig. 7 A is zero position before treatment, and the starting point of prostate volume load module, age input module and prostate health index variable load module is all positioned at separately that residing input slot is foremost. As shown in Figure 7 B, then position is adjusted by processing module: the site of the prostate volume variable first received by prostate volume load module is set to the initial point position of age input module, the terminal of age variable age input module received is set to the initial point position of prostate health index load module, and the terminal site of the prostate health index variable received by prostate health index load module is treated to and exports site. In the example shown, the prostate volume of such as patient is 45ml, and the age is 60 years old, and prostate health index (PHI) is that the patient measured by 65 these devices occurs the possibility of prostate cancer to be 0.558.
As shown in Figure 6, output module is provided with the scale (such as representing the probability of occurrence of 0-1) of the forecasting risk value of prostate cancer, exports the positive rate that site corresponding on scale, site is first visit aspiration biopsy of prostatic gland and suffers from cancer risk.
Certainly, except the device manifestation mode shown in above-mentioned accompanying drawing, it is also possible to replace aforesaid rectangle device with circular apparatus as shown in Figure 8, owing to its using method, principle and apparatus structure are identical with rectangle device, do not repeat them here.
Thering is provided previous description of the present disclosure is for making any person skilled in the art all can make or use the disclosure. To be all apparent for a person skilled in the art to various amendment of the present disclosure, and generic principles as defined herein can be applied to other variants and can not depart from spirit or scope of the present disclosure. Thus, the disclosure and not intended to be is defined to example described herein and design, but the widest scope consistent with principle disclosed herein and novel features should be awarded.
Claims (7)
1. predict that aspiration biopsy of prostatic gland suffers from the device of prostate cancer risk for one kind, it is characterised in that, described device comprises:
Input unit, receives the age variable of first visit prostate biopsy patient, prostate volume variable and prostate health index (PHI) variable;
Treatment unit, connects described input unit, based on described age variable, described prostate volume variable and described prostate health index variable, obtains the positive rate P of the prostate biopsy of described first visit prostate biopsy patient according to formula, and described formula is:
P=1/{1+exp [-(-11.4391+0.083*Age-0.0103*Volume+0.1096*PHI)] }
Wherein, Age represents described age variable, and PHI represents described prostate health index variable, and Volume represents described prostate volume variable;
Take-off equipment, connects described treatment unit, exports the forecasting risk value that described device finally obtains.
2. prediction aspiration biopsy of prostatic gland according to claim 1 suffers from the device of prostate cancer risk, it is characterised in that, described input unit comprises:
Memory module, is provided with three input slots, and described three input slots are respectively pickup groove, first and chute, the 2nd can be supplied can to supply chute;
Three load modules, described three load modules be respectively be placed in described pickup groove prostate health index load module, be placed on described first can for the prostate volume load module in chute and be placed on the described 2nd can for the age input module in chute, wherein said prostate health index load module is for inputting described prostate health index variable, described prostate volume load module is for inputting described prostate volume variable, and described age input module is for inputting described age variable.
3. prediction aspiration biopsy of prostatic gland according to claim 2 suffers from the device of prostate cancer risk, it is characterized in that, described processing module is used for being adjusted the position of described three load modules in each input slot of described memory module, obtains and exports site.
4. prediction aspiration biopsy of prostatic gland according to claim 3 suffers from the device of prostate cancer risk, it is characterized in that, the position adjustment of described processing module is: the site of the described prostate volume variable received by described prostate volume load module is set to the initial point position of described age input module, the terminal of the described age variable described age input module received is set to the initial point position of described prostate health index load module, the terminal site of the described prostate health index variable received by described prostate health index load module is treated to described output site.
5. prediction aspiration biopsy of prostatic gland according to claim 4 suffers from the device of prostate cancer risk, it is characterized in that, described output module is provided with the scale of the forecasting risk value of prostate cancer, and the site of described output site correspondence on described scale is the positive rate that first visit aspiration biopsy of prostatic gland suffers from cancer risk.
6. predict that aspiration biopsy of prostatic gland suffers from the device of prostate cancer risk for one kind, it is characterised in that, described device comprises:
Memory module, is provided with three input slots, is respectively pickup groove, first and chute, the 2nd can be supplied can to supply chute;
Three load modules, be respectively be placed in described pickup groove prostate health index (PHI) variable load module, be placed on described first can for the prostate volume load module in chute and be placed on the 2nd can for the age input module in chute, wherein, described prostate health index variable load module is for inputting prostate health index variable, described prostate volume load module is for inputting prostate volume variable, and described age input module is for inputting age variable;
Processing module, for being adjusted the position of described three load modules in each input slot of described memory module, obtains and exports site;
Output module, is provided with the scale of the forecasting risk value of prostate cancer, and the site of described output site correspondence on described scale is the positive rate that first visit aspiration biopsy of prostatic gland suffers from cancer risk.
7. prediction aspiration biopsy of prostatic gland according to claim 6 suffers from the device of prostate cancer risk, it is characterized in that, the position adjustment of described processing module is: the site of the described prostate volume variable received by described prostate volume load module is set to the initial point position of described age input module, the terminal of the described age variable described age input module received is set to the initial point position of described prostate health index load module, the terminal site of the described prostate health index variable received by described prostate health index load module is treated to described output site.
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| CN201610178548.4A CN105653886B (en) | 2016-03-25 | 2016-03-25 | A kind of prediction aspiration biopsy of prostatic gland suffers from the device of prostate cancer risk |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109599175A (en) * | 2018-12-04 | 2019-04-09 | 中山大学孙逸仙纪念医院 | A kind of analysis of joint destroys the device and method of progress probability |
| CN110993095A (en) * | 2019-11-26 | 2020-04-10 | 上海市第十人民医院 | Device for predicting prostate carcinogenesis and metastasis |
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| EP1102200A2 (en) * | 1999-11-16 | 2001-05-23 | Cardiac Intelligence Corporation | Automated collection and analysis patient care system and method for ordering and prioritizing multiple health disorders to identify an index disorder |
| CN102968558A (en) * | 2012-11-14 | 2013-03-13 | 叶定伟 | Device for predicting bone metastasis risk of newly-diagnosed prostate cancer |
| CN105243283A (en) * | 2015-11-06 | 2016-01-13 | 吴志宏 | Prostate cancer diagnosis and treatment information acquisition system |
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2016
- 2016-03-25 CN CN201610178548.4A patent/CN105653886B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH1011523A (en) * | 1996-02-02 | 1998-01-16 | Smithkline Beecham Corp | Method and system for labelling patient having danger to be diagnosed as depression |
| EP1102200A2 (en) * | 1999-11-16 | 2001-05-23 | Cardiac Intelligence Corporation | Automated collection and analysis patient care system and method for ordering and prioritizing multiple health disorders to identify an index disorder |
| CN102968558A (en) * | 2012-11-14 | 2013-03-13 | 叶定伟 | Device for predicting bone metastasis risk of newly-diagnosed prostate cancer |
| CN105243283A (en) * | 2015-11-06 | 2016-01-13 | 吴志宏 | Prostate cancer diagnosis and treatment information acquisition system |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109599175A (en) * | 2018-12-04 | 2019-04-09 | 中山大学孙逸仙纪念医院 | A kind of analysis of joint destroys the device and method of progress probability |
| CN110993095A (en) * | 2019-11-26 | 2020-04-10 | 上海市第十人民医院 | Device for predicting prostate carcinogenesis and metastasis |
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| CN105653886B (en) | 2018-08-14 |
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