CN105641684A - Spraying agent for restoration after hemorrhoidectiomy and preparation method thereof - Google Patents
Spraying agent for restoration after hemorrhoidectiomy and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a spraying agent for restoration after hemorrhoidectiomy, comprising the following components: 0.8-2.4% of tectorigenin, 1.2-3.0% of nystatin, 0.9-1.8% of panaxoside, 0.05-0.08% of recombinant human epidermal growth factor, 0.3-0.6% of natural borneol, 0.5-1.0% of antioxidant, 3-8% of ethanol, 0.2-0.5% of preservative, 0.6-1.4% of penetration enhancer, 0.7-1.3% of coenzyme Q10, 0.3-0.9% of toosendanin and balance of normal saline. The spraying agent for restoration after hemorrhoidectiomy has good antibiotic, disinfectant, infection resistant and hemostasis effects, effectively promotes absorption of skin for effective ingredients of the medicament, accelerates cellular metabolism, rehabilitates skin in the surgical site, prevents recurrence of hemorrhoids, and has the advantages of mild drug effect, small irritation on wounds, no adverse reaction and good clinical effect.
Description
Technical field
The present invention relates to surgical medicine technical field, be specifically related to a kind of spray for hemorrhoid post-operative recovery and preparation method thereof.
Background technology
Hemorrhoid are a kind of common diseases being positioned at anus position, and any age all can fall ill, but with age, sickness rate is gradually increased. In China, hemorrhoid are modal anal and intestinal diseases, have the saying of " ten male nine hemorrhoid ", " ten female ten hemorrhoid ", its pathogenic factor mainly has two kinds of sayings: be first varicosis theory, it is believed that hemorrhoid are the vein groups formed with the venous plexus congestion under anal canal skin, expansion and flexing under distal rectal mucosa; But current well accepted theory is that anus pad moves down theory, it is believed that hemorrhoid are the normal anatomical structures in anal canal position originally, i.e. blood vessel pad, it it is the ring-type cavernous transformation taeniae telarum of pectinate line and above 1.5cm. The risk factor of hemorrhoid is a lot, and wherein constipation, long-term alcohol, a large amount of irritable food of feed and sitting standing for a long time are main inducing, are divided into internal hemorrhoid, external hemorrhoid, mixed hemorrhoid by the difference of happening part. The main clinical manifestation of symptom has: have blood in stool, and its character is painless, intermittent, blood after an action of the bowels mainly, bleeds or band blood on toilet paper time just, constipation, drinks or irritable food postemphasis of taking food; Pure internal hemorrhoid, can be hemorrhage without pain only falling inflation sense, is developed to prolapsus, pain just occurs when merging thrombosis, incarceration, infection; Pain is uncomfortable, pruritus, and wherein pruritus is often due to toughness secretions outflow when hemorrhoid are deviate from; External hemorrhoid, at ordinary times without characteristic symptom, occurs can have swelling, pain when thrombosis and inflammation.
The clinical treatment of current hemorrhoid mainly has non-operative treatment and operative treatment two kinds, performance different quality method according to symptom is different, the hemorrhoid of general symptom are based on local application and physiotherapy, the adjustment coordinating dietary habit can relief of symptoms, then need when expectant treatment is invalid and hemorrhoid are deviate from serious to carry out operative treatment, repair and remove abnormal structure, keep anorectal position normal thus recovering stool control mode ability, therefore postoperative recovery is also very important, need a kind of medicine can alleviate the pain of patient, anti-inflammation can be played again, reduce hemorrhage, promote the effect of wound healing.
Summary of the invention
Present invention solves the technical problem that and be to provide a kind of spray for hemorrhoid post-operative recovery and preparation method thereof.
For solving above-mentioned technical problem, the technical solution adopted in the present invention is as follows:
A kind of spray for hemorrhoid post-operative recovery, its one-tenth is grouped into: tectorigenin 0.8��2.4%, nystatin 1.2��3.0%, ginsenoside 0.9��1.8%, recombinant human epidermal growth factor 0.05��0.08%, natural Broneolum Syntheticum 0.3��0.6%, antioxidant 0.5��1.0%, ethanol 3��8%, preservative 0.2��0.5%, penetrating agent 0.6��1.4%, coenzyme Q10 0.7��1.3%, river bran element 0.3��0.9%, surplus are normal saline.
Further, the mass concentration of described ethanol is 65��75%.
Further, described antioxidant is vitamin C, in human body, vitamin C is efficient antioxidant, alleviate the oxidation stress of ascorbate peroxidase enzyme substrate, nonheme iron absorption, free radical resisting can be promoted, it is suppressed that the formation of tryrosinase simultaneously, and there is whitening, effect of light speckle.
Further, described preservative is sodium benzoate, sodium benzoate is the food, the pharmaceutical preservative with no toxicity that are in daily use, and sodium benzoate lipophile is relatively big, and easy permeates cell membranes enters in cyton, the permeability of interference cell film, suppress cell membrane to amino acid whose absorption, enter the intracellular alkali storage of cyton internal ionization acidifying, and suppress the activity of the respiratory enzyme system of cell, stop S-acetyl-coenzyme-A condensation reaction, thus playing antiseptical purpose.
Further, described penetrating agent is azone, and it is the dermal osmosis accelerator that osmosis is fabulous in medicine and cosmetic industry.
Further, the preparation method of a kind of spray for hemorrhoid post-operative recovery is: by ginsenoside, coenzyme Q10, ethanol is according to described ratio mix homogeneously, add the compound enzyme of 0.08%, described compound enzyme is glycosidase and enterokinase to be mixed according to the weight ratio of 1:2, can be effectively promoted in mixed liquor the fast hydrolyzing of polysaccharose substance, and make trypsinogen hydrolysis become active chymotrypsin and promote that skin epidermis is to the amino acid whose absorption of multiple beneficial, stirring and dissolving, give the normal saline adding described ratio in lysate again, it is placed in blender to stir according to 60r/min speed, whipping process is separately added into tectorigenin, nystatin, recombinant human epidermal growth factor, natural Broneolum Syntheticum, antioxidant, preservative, penetrating agent, river bran element, then the speed stirring 30min of 600r/min is further accelerated, after mixed solution after stirring is placed in homogenizer homogenizing processing 15min, the ultrafiltration post ultrafiltration that molecular weight is 5000��6000 then through damming, obtain ultrafiltrate, after packaging, low temperature is sealed up for safekeeping, namely the spray for hemorrhoid post-operative recovery is prepared.
The invention has the beneficial effects as follows: the spray for hemorrhoid post-operative recovery of the present invention has good antibiotic and sterilizing, infection, anastalsis, it is effectively promoted the skin absorption to effective ingredient, and cellular metabolism can be accelerated, improve the skin quality of operative site, preventing hemorrhoid from recurring, drug effect is gentle, and wound zest is little, without any untoward reaction, there is good clinical effectiveness.
Detailed description of the invention
Embodiment 1:
A kind of spray for hemorrhoid post-operative recovery, its one-tenth is grouped into: tectorigenin 0.8%, nystatin 1.2%, ginsenoside 0.9%, recombinant human epidermal growth factor 0.05%, natural Broneolum Syntheticum 0.3%, antioxidant 0.5%, ethanol 3%, preservative 0.2%, penetrating agent 0.6%, coenzyme Q10 0.7%, river bran element 0.3%, surplus are normal saline.
Wherein, the mass concentration of described ethanol is 65%; Described antioxidant is vitamin C, and in human body, vitamin C is efficient antioxidant, alleviates the oxidation stress of ascorbate peroxidase enzyme substrate, nonheme iron absorption, free radical resisting can be promoted, it is suppressed that the formation of tryrosinase simultaneously, and there is whitening, effect of light speckle; Described preservative is sodium benzoate, sodium benzoate is the food, the pharmaceutical preservative with no toxicity that are in daily use, sodium benzoate lipophile is bigger, easy permeates cell membranes enters in cyton, the permeability of interference cell film, it is suppressed that cell membrane is to amino acid whose absorption, enter the intracellular alkali storage of cyton internal ionization acidifying, and suppress the activity of the respiratory enzyme system of cell, stop S-acetyl-coenzyme-A condensation reaction, thus playing antiseptical purpose; Described penetrating agent is azone, and it is the dermal osmosis accelerator that osmosis is fabulous in medicine and cosmetic industry.
The preparation method of this spray is: by ginsenoside, coenzyme Q10, ethanol is according to described ratio mix homogeneously, stirring and dissolving, give the normal saline adding described ratio in lysate again, it is placed in blender to stir according to 60r/min speed, whipping process is separately added into tectorigenin, nystatin, recombinant human epidermal growth factor, natural Broneolum Syntheticum, antioxidant, preservative, penetrating agent, river bran element, then the speed stirring 30min of 600r/min is further accelerated, after mixed solution after stirring is placed in homogenizer homogenizing processing 15min, the ultrafiltration post ultrafiltration that molecular weight is 5000 then through damming, obtain ultrafiltrate, after packaging, low temperature is sealed up for safekeeping, namely the spray for hemorrhoid post-operative recovery is prepared.
Embodiment 2:
A kind of spray for hemorrhoid post-operative recovery, its one-tenth is grouped into: tectorigenin 1.6%, nystatin 2.1%, ginsenoside 1.35%, recombinant human epidermal growth factor 0.065%, natural Broneolum Syntheticum 0.4%, antioxidant 0.75%, ethanol 0.55%, preservative 0.35%, penetrating agent 1.0%, coenzyme Q10 1.0%, river bran element 0.6%, surplus are normal saline.
Wherein, the mass concentration of described ethanol is 70%; Described antioxidant is vitamin C, and in human body, vitamin C is efficient antioxidant, alleviates the oxidation stress of ascorbate peroxidase enzyme substrate, nonheme iron absorption, free radical resisting can be promoted, it is suppressed that the formation of tryrosinase simultaneously, and there is whitening, effect of light speckle; Described preservative is sodium benzoate, sodium benzoate is the food, the pharmaceutical preservative with no toxicity that are in daily use, sodium benzoate lipophile is bigger, easy permeates cell membranes enters in cyton, the permeability of interference cell film, it is suppressed that cell membrane is to amino acid whose absorption, enter the intracellular alkali storage of cyton internal ionization acidifying, and suppress the activity of the respiratory enzyme system of cell, stop S-acetyl-coenzyme-A condensation reaction, thus playing antiseptical purpose; Described penetrating agent is azone, and it is the dermal osmosis accelerator that osmosis is fabulous in medicine and cosmetic industry.
The preparation method of this spray is: by ginsenoside, coenzyme Q10, ethanol is according to described ratio mix homogeneously, stirring and dissolving, give the normal saline adding described ratio in lysate again, it is placed in blender to stir according to 60r/min speed, whipping process is separately added into tectorigenin, nystatin, recombinant human epidermal growth factor, natural Broneolum Syntheticum, antioxidant, preservative, penetrating agent, river bran element, then the speed stirring 30min of 600r/min is further accelerated, after mixed solution after stirring is placed in homogenizer homogenizing processing 15min, the ultrafiltration post ultrafiltration that molecular weight is 5500 then through damming, obtain ultrafiltrate, after packaging, low temperature is sealed up for safekeeping, namely the spray for hemorrhoid post-operative recovery is prepared.
Embodiment 3:
A kind of spray for hemorrhoid post-operative recovery, its one-tenth is grouped into: tectorigenin 2.4%, nystatin 3.0%, ginsenoside 1.8%, recombinant human epidermal growth factor 0.08%, natural Broneolum Syntheticum 0.6%, antioxidant 1.0%, ethanol 8%, preservative 0.5%, penetrating agent 1.4%, coenzyme Q10 1.3%, river bran element 0.9%, surplus are normal saline.
Wherein, the mass concentration of described ethanol is 75%; Described antioxidant is vitamin C, and in human body, vitamin C is efficient antioxidant, alleviates the oxidation stress of ascorbate peroxidase enzyme substrate, nonheme iron absorption, free radical resisting can be promoted, it is suppressed that the formation of tryrosinase simultaneously, and there is whitening, effect of light speckle; Described preservative is sodium benzoate, sodium benzoate is the food, the pharmaceutical preservative with no toxicity that are in daily use, sodium benzoate lipophile is bigger, easy permeates cell membranes enters in cyton, the permeability of interference cell film, it is suppressed that cell membrane is to amino acid whose absorption, enter the intracellular alkali storage of cyton internal ionization acidifying, and suppress the activity of the respiratory enzyme system of cell, stop S-acetyl-coenzyme-A condensation reaction, thus playing antiseptical purpose; Described penetrating agent is azone, and it is the dermal osmosis accelerator that osmosis is fabulous in medicine and cosmetic industry.
The preparation method of this spray is: by ginsenoside, coenzyme Q10, ethanol is according to described ratio mix homogeneously, stirring and dissolving, give the normal saline adding described ratio in lysate again, it is placed in blender to stir according to 60r/min speed, whipping process is separately added into tectorigenin, nystatin, recombinant human epidermal growth factor, natural Broneolum Syntheticum, antioxidant 1.0%, preservative 0.5%, penetrating agent 1.4%, river bran element, then the speed stirring 30min of 600r/min is further accelerated, after mixed solution after stirring is placed in homogenizer homogenizing processing 15min, the ultrafiltration post ultrafiltration that molecular weight is 6000 then through damming, obtain ultrafiltrate, after packaging, low temperature is sealed up for safekeeping, namely the spray for hemorrhoid post-operative recovery is prepared.
Experimental verification:
1, experimental subject: carried out patient 100 example of hemorrhoid operation, and be divided into 2 groups, often organize 50 people, be designated as test group, matched group respectively.
2, experimental technique:
To spray prepared by the case affected part of the test group use present invention, sooner or later respectively once, until wound heals completely; Conventional postoperative disinfectant solution is used, until wound heals completely to the case affected part of matched group.
3, Comparative result:
Test group: the average time of wound healing is shorter 4 days than matched group, quickly subside a swelling in operation affected part, not hemorrhage, and after recovery from illness, cicatrix obscures, and skin smooth did not all recur in half a year.
Matched group: slowly, interval has hemorrhage on a small quantity in wound detumescence, and after recovery from illness, cicatrix is obvious, has in 9 patient half a year and again occurs slightly having blood in stool.
4, conclusion: be may certify that by experiment above, all having for various hemorrhoid post-operative recovery for the spray of hemorrhoid post-operative recovery of the present invention promotes Healing preferably, and can prevent from infecting, desalination cicatrix, improves skin quality, has general applicability, and safely and effectively, have no side effect.
Model case:
Case 1: Wang, female, 25 years old, white collar, due to job demand, long-term sitting, occur that intermittence is had blood in stool the year before, check after three months that hemorrhoid are deviate from seriously, affect normal operation, in being by operative treatment, the postoperative spray for hemorrhoid post-operative recovery namely beginning to use the embodiment of the present invention 1 to prepare, every day is sprayed on affected part twice sooner or later, and after 2 days, pain disappears, wound healing after 4 days, after being continuing with 5 days, affected part cortex is smooth, cicatrix obscures, and follows up a case by regular visits to, have no recurrence after half a year.
Case 2: Hu, man, 48 years old, long-term smoking is addicted to drink, and lives irregular, occurred having blood in stool before half a year, it is diagnosed as thrombosed external hemorrhoid after inspection, having carried out operative treatment, the postoperative spray for hemorrhoid post-operative recovery beginning to use the embodiment of the present invention 2 to prepare after expectant treatment is invalid, every day is sprayed on affected part twice sooner or later, after 2 days, the fritter hematoma of wound disappears, wound healing after 5 days, stool is normal, and return visit in three months is not recurred.
Case 3: section so-and-so, female 35 years old, diet is based on spicy for many years, there will be intermittence during sweltering heat in summer to have blood in stool, had blood in stool continuously before three months one week, it is diagnosed as bigger fibroid internal hemorrhoid after inspection, in addition there is infection on internal hemorrhoid surface, Milligan-Morgan methods has been carried out after antibiotic therapy eliminates and infects, the spray for hemorrhoid post-operative recovery of postoperative use embodiment 3 preparation, every day is sprayed on affected part twice sooner or later, wound healing after 4 days, defecate unimpeded, fully recover after being continuing with 5 days, paid a return visit before one month and do not recur.
Last it is noted that above example is only in order to illustrate technical scheme, it is not intended to limit; Although the present invention being described in detail with reference to previous embodiment, it will be understood by those within the art that: the technical scheme described in previous embodiment still can be modified by it, or wherein portion of techniques feature is carried out equivalent replacement; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (6)
1. the spray for hemorrhoid post-operative recovery, it is characterized in that, its one-tenth is grouped into: tectorigenin 0.8��2.4%, nystatin 1.2��3.0%, ginsenoside 0.9��1.8%, recombinant human epidermal growth factor 0.05��0.08%, natural Broneolum Syntheticum 0.3��0.6%, antioxidant 0.5��1.0%, ethanol 3��8%, preservative 0.2��0.5%, penetrating agent 0.6��1.4%, coenzyme Q10 0.7��1.3%, river bran element 0.3��0.9%, surplus are normal saline.
2. a kind of spray for hemorrhoid post-operative recovery as claimed in claim 1, it is characterised in that the mass concentration of described ethanol is 65��75%.
3. a kind of spray for hemorrhoid post-operative recovery as claimed in claim 1, it is characterised in that described antioxidant is vitamin C.
4. a kind of spray for hemorrhoid post-operative recovery as claimed in claim 1, it is characterised in that described preservative is sodium benzoate.
5. a kind of spray for hemorrhoid post-operative recovery as claimed in claim 1, it is characterised in that described penetrating agent is azone.
6. a kind of spray for hemorrhoid post-operative recovery as claimed in claim 1, it is characterized in that preparation method is: by ginsenoside, coenzyme Q10, ethanol is according to described ratio mix homogeneously, add the compound enzyme of 0.08%, stirring and dissolving, give the normal saline adding described ratio in lysate again, it is placed in blender to stir according to 60r/min speed, whipping process is separately added into tectorigenin, nystatin, recombinant human epidermal growth factor, natural Broneolum Syntheticum, antioxidant, preservative, penetrating agent, river bran element, then the speed stirring 30min of 600r/min is further accelerated, after mixed solution after stirring is placed in homogenizer homogenizing processing 15min, the ultrafiltration post ultrafiltration that molecular weight is 5000��6000 then through damming, obtain ultrafiltrate, after packaging, low temperature is sealed up for safekeeping, namely the spray for hemorrhoid post-operative recovery is prepared.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610015746.9A CN105641684A (en) | 2016-01-11 | 2016-01-11 | Spraying agent for restoration after hemorrhoidectiomy and preparation method thereof |
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| CN201610015746.9A CN105641684A (en) | 2016-01-11 | 2016-01-11 | Spraying agent for restoration after hemorrhoidectiomy and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107362284A (en) * | 2017-08-23 | 2017-11-21 | 靖西市民族医药协会 | A kind of antihaemorrhoidals water |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104096034A (en) * | 2014-06-29 | 2014-10-15 | 虞志秋 | External medicine used for facilitating recovery after haemorrhoids operation |
| CN104352914A (en) * | 2014-10-13 | 2015-02-18 | 刘新霞 | Care solution used after hemorrhoidectomy |
| CN105079361A (en) * | 2015-09-11 | 2015-11-25 | 吕兵 | Cleaning care solution applied after hemorrhoid operation |
-
2016
- 2016-01-11 CN CN201610015746.9A patent/CN105641684A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104096034A (en) * | 2014-06-29 | 2014-10-15 | 虞志秋 | External medicine used for facilitating recovery after haemorrhoids operation |
| CN104352914A (en) * | 2014-10-13 | 2015-02-18 | 刘新霞 | Care solution used after hemorrhoidectomy |
| CN105079361A (en) * | 2015-09-11 | 2015-11-25 | 吕兵 | Cleaning care solution applied after hemorrhoid operation |
Non-Patent Citations (2)
| Title |
|---|
| 孙美春: "痔疮患者术后用中药熏洗伤口的疗效观察与护理", 《上海护理》 * |
| 胡献国等: "《中国膏药配方配制全书》", 30 April 2014, 辽宁科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107362284A (en) * | 2017-08-23 | 2017-11-21 | 靖西市民族医药协会 | A kind of antihaemorrhoidals water |
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