CN105608319B - A kind of mask method and annotation equipment of digital pathological section - Google Patents
A kind of mask method and annotation equipment of digital pathological section Download PDFInfo
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- CN105608319B CN105608319B CN201510967160.8A CN201510967160A CN105608319B CN 105608319 B CN105608319 B CN 105608319B CN 201510967160 A CN201510967160 A CN 201510967160A CN 105608319 B CN105608319 B CN 105608319B
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Abstract
The present invention provides a kind of mask method of digital pathological section and annotation equipments, wherein this method comprises: the mark graph style of the location information for the mark point that monitoring users are chosen on digital pathological section display interface and user's selection；Mark figure is drawn on digital pathological section display interface according to the location information of mark point and mark graph style；It is that user is inputted in predetermined input frame to be set on display interface with mark graphical association markup information；Wherein, markup information includes at least one of: mark theme, marked content, mark graphic color.The embodiment of the present invention is in real time labeled area to be studied in such a way that figure labeling is combined with information labeling, realize the mode of multi-form mark, be conducive to other users or user is subsequent timely and accurately views area to be studied, meets the actual demand of user study digital pathological section.
Description
Technical field
The present invention relates to digital pathological section technical fields, in particular to a kind of mark side of digital pathological section
Method and annotation equipment.
Background technique
With the development of image display technology, modern medicine applies image display technology in terms of pathological section, to biography
System pathological section is scanned, and obtains the digital pathological section that can be shown using computer or other display equipment, and doctor passes through observation
Digital pathological section carries out condition-inference.Compared with traditional glass slice, digital pathological section has display multiplying power high, clarity
High, observation conveniently, the advantages of consultation of doctors simultaneously convenient for more people, is widely used in modern medicine.
During computer or other display equipment display digital pathological section, it is often necessary to on digital pathological section image
A certain specific position is labeled, to meet other users or use that family is subsequent can accurately to view the tab area instead
Demand.However, one is the sides of verbal description there are two types of a kind of notation methods of the digital pathological section provided in the prior art
Formula, the notation methods be in the input passage description of area to be studied neighbouring position, but cannot in the way of verbal description
The physical location for accurately indicating area to be studied, can not accurately find text so as to cause other users or the user are subsequent
Survey region represented by word description；Another kind is the mode of region screenshot, which then needs other users to navigate to
Physical location of the interception part in complete digital pathological section, and then the position is checked, is analyzed.
In the implementation of the present invention, inventor is had found the above-mentioned notation methods using verbal description and is cut using region
The notation methods of figure are not easy to other users or user are subsequent timely and accurately views area to be studied, are unable to satisfy
The actual demand of user study digital pathological section.
Summary of the invention
In view of this, the mask method and mark dress for being designed to provide a kind of digital pathological section of the embodiment of the present invention
It sets, to solve the above problems.
In a first aspect, the embodiment of the invention provides a kind of mask methods of digital pathological section, this method comprises:
The location information for the mark point that monitoring users are chosen on digital pathological section display interface and the mark of user's selection
Infuse graph style, wherein above-mentioned digital pathological section is the digital picture by obtaining after being scanned to pathological section；
According to the location information of above-mentioned mark point and above-mentioned mark graph style in above-mentioned digital pathological section display interface
Upper drafting marks figure；
It is that above-mentioned user is inputted in predetermined input frame be set to above-mentioned mark graphical association markup information it is above-mentioned
On display interface；Wherein, above-mentioned markup information includes at least one of: mark theme, marked content, mark graphic color.
With reference to first aspect, the embodiment of the invention provides the first possible embodiments of first aspect, wherein on
It states and is drawn on above-mentioned digital pathological section display interface according to the location information and above-mentioned mark graph style of above-mentioned mark point
Mark figure, comprising:
When the mark graph style that above-mentioned user selects is regular figure, with the initial point position letter in above-mentioned mark point
Point centered on the corresponding coordinate of breath, draws above-mentioned regular figure on above-mentioned digital pathological section display interface；
When the mark graph style that above-mentioned user selects is irregular shape, according to each point in above-mentioned mark point
The corresponding coordinate of confidence breath is adjacent two-by-two successively to draw straight line, draws on above-mentioned digital pathological section display interface closed
Irregular shape.
The possible embodiment of with reference to first aspect the first, the embodiment of the invention provides second of first aspect
Possible embodiment, wherein point centered on the coordinate corresponding to the initial point position information in above-mentioned mark point, above-mentioned
Above-mentioned regular figure is drawn on digital pathological section display interface, comprising:
When the mark graph style that above-mentioned user selects is flag, with coordinate corresponding to initial point position information it is
Heart point draws flag figure on above-mentioned digital pathological section display interface；
When the mark graph style that above-mentioned user selects is rectangle, with coordinate corresponding to initial point position information it is
Heart point is for twice with the distance between coordinate corresponding to coordinate corresponding to initial point position information and end point location information
Diagonal line draws rectangular area on above-mentioned digital pathological section display interface；
When the mark graph style that above-mentioned user selects is round, with coordinate corresponding to initial point position information it is
Heart point, with the distance between coordinate corresponding to coordinate corresponding to initial point position information and end point location information for radius,
Border circular areas is drawn on above-mentioned digital pathological section display interface；
When the mark graph style that above-mentioned user selects is oval, with coordinate corresponding to initial point position information it is
Heart point, with twice of the distance between coordinate corresponding to coordinate corresponding to initial point position information and end point location information
To draw inner ellipse region on above-mentioned digital pathological section display interface in cornerwise rectangle.
Any into second of possible embodiment of first aspect with reference to first aspect, the embodiment of the present invention provides
The third possible embodiment of first aspect, wherein the above method further include:
The above-mentioned markup information of the above-mentioned mark figure of drafting and setting is converted into the above-mentioned digital corresponding seat of case slice
Actual graphical parameter and practical markup information under mark system；
Store the corresponding relationship of above-mentioned digital case slice and above-mentioned actual graphical parameter and practical markup information, wherein
Above-mentioned actual graphical parameter includes at least one of the following: the upper left angle point phase of circumscribed rectangle corresponding to above-mentioned mark figure
Coordinate, drafting display multiplying power, the length of rectangle, the width of rectangle, circular radius, Yi Jijian for above-mentioned digital pathological section
The set for the coordinate points heard.
The third possible embodiment with reference to first aspect, the embodiment of the invention provides the 4th kind of first aspect
Possible embodiment, wherein the above-mentioned markup information of the above-mentioned mark figure of drafting and setting is converted into above-mentioned number disease
Actual graphical parameter and practical markup information under example slice respective coordinates system, comprising:
Determine coordinate of the upper left angle point of circumscribed rectangle corresponding to above-mentioned mark figure relative to display interface；
According to reduction formula Bx=Px+LxAnd By=Py+LyBy the upper left angle point of above-mentioned circumscribed rectangle relative to display interface
Coordinate transformation be coordinate relative to above-mentioned digital pathological section, wherein (Px, Py) be circumscribed rectangle upper left angle point it is opposite
In the coordinate of display interface, (Bx, By) it is the coordinate that the upper left angle point of circumscribed rectangle is sliced relative to digital case, (Lx, Ly) be
Draw offset of the digital case slicing edge relative to display interface under display multiplying power.
The third possible embodiment with reference to first aspect, the embodiment of the invention provides the 5th kind of first aspect
Possible embodiment, wherein the above method further include:
Obtain the current display multiplying power of above-mentioned digital pathological section, the above-mentioned actual graphical parameter of storage and practical mark letter
Breath；
The above-mentioned actual graphical parameter of storage and above-mentioned practical markup information are converted to according to above-mentioned current display multiplying power
Display graphic parameter and display markup information under above-mentioned display interface respective coordinates system；
Currently display multiplying power under, shown on the display interface of above-mentioned digital pathological section above-mentioned display graphic parameter and
Show markup information.
The 5th kind of possible embodiment with reference to first aspect, the embodiment of the invention provides the 6th kind of first aspect
Possible embodiment, wherein marked the above-mentioned actual graphical parameter of storage and above-mentioned reality according to above-mentioned current display multiplying power
Note information is converted to display graphic parameter and display markup information under above-mentioned display interface respective coordinates system, comprising:
According to formulaBy the above-mentioned actual graphical parameter of storage and above-mentioned practical markup information be scaled with
The above-mentioned current actual graphical parameter that matches of display multiplying power and practical markup information, wherein A is and currently shows multiplying power phase
Perhaps practical markup information a is the actual graphical parameter of storage to the actual graphical parameter matched or practical markup information, clay are
Current display multiplying power, γ are to draw display multiplying power；
According to reduction formula Cx=Ax+ηxAnd Cy=Ay+ηyThe actual graphical to match with above-mentioned current display multiplying power is joined
Several and practical markup information is scaled display graphic parameter and display markup information relative to above-mentioned display interface, wherein
(Ax, Ay) it is the coordinate of actual graphical parameter or practical markup information relative to digital pathological section, (Cx, Cy) it is practical figure
The coordinate of shape parameter or practical markup information relative to display interface, (ηx, ηy) it is digital case slice under current display multiplying power
Offset of the edge relative to display interface.
Second aspect, the embodiment of the invention also provides a kind of annotation equipment of digital pathological section, which includes:
Monitor module, for monitoring users chosen on digital pathological section display interface mark point location information and
The mark graph style of user's selection, wherein above-mentioned digital pathological section is by obtaining after being scanned to pathological section
Digital picture；
Graphic plotting module is marked, for the location information and above-mentioned mark graph style according to above-mentioned mark point above-mentioned
Mark figure is drawn on digital pathological section display interface；
Markup information setup module, for inputting above-mentioned user in predetermined input frame with above-mentioned mark graphical association
Markup information be set on above-mentioned display interface；Wherein, above-mentioned markup information includes at least one of: mark theme, mark
Infuse content, mark graphic color.
In conjunction with second aspect, the embodiment of the invention provides the first possible embodiments of second aspect, wherein on
State device further include:
First conversion module, for the above-mentioned markup information of the above-mentioned mark figure drawn and setting to be converted to above-mentioned number
Word case is sliced actual graphical parameter and practical markup information under respective coordinates system；
Memory module, for storing pair of above-mentioned digital case slice and above-mentioned actual graphical parameter and practical markup information
It should be related to, wherein above-mentioned actual graphical parameter includes at least one of the following: circumscribed rectangle corresponding to above-mentioned mark figure
Upper left angle point relative to above-mentioned digital pathological section coordinate, draw display multiplying power, the length of rectangle, the width of rectangle, circle
The set of shape radius and the coordinate points listened to.
In conjunction with second aspect, the embodiment of the invention provides second of possible embodiments of second aspect, wherein on
State device further include:
Module is obtained, for obtaining current display multiplying power, the above-mentioned actual graphical of the storage ginseng of above-mentioned digital pathological section
Several and practical markup information；
Second conversion module, for according to above-mentioned current display multiplying power by the above-mentioned actual graphical parameter of storage and above-mentioned reality
Border markup information is converted to display graphic parameter and display markup information under above-mentioned display interface respective coordinates system；
Display module, for being shown on the display interface of above-mentioned digital pathological section above-mentioned under currently display multiplying power
Show graphic parameter and display markup information.
In method and device provided in an embodiment of the present invention, this method comprises: monitoring users are aobvious in digital pathological section
Show the location information for the mark point chosen on interface and the mark graph style of user's selection；According to mark point location information and
Mark graph style draws mark figure on digital pathological section display interface；User is inputted in predetermined input frame with
The markup information of mark graphical association is set on display interface；Wherein, markup information includes at least one of: mark master
Topic, marked content, mark graphic color.The embodiment of the present invention is right in real time in such a way that figure labeling is combined with information labeling
Area to be studied is labeled, and realizes the mode of multi-form mark, is conducive to other users or user is subsequent promptly and accurately
Ground views area to be studied, meets the actual demand of user study digital pathological section.
To enable the above objects, features and advantages of the present invention to be clearer and more comprehensible, preferred embodiment is cited below particularly, and cooperate
Appended attached drawing, is described in detail below.
Detailed description of the invention
In order to illustrate the technical solution of the embodiments of the present invention more clearly, below will be to needed in the embodiment attached
Figure is briefly described, it should be understood that the following drawings illustrates only certain embodiments of the present invention, therefore is not construed as pair
The restriction of range for those of ordinary skill in the art without creative efforts, can also be according to this
A little attached drawings obtain other relevant attached drawings.
Fig. 1 shows a kind of flow chart of the mask method of digital pathological section provided by the embodiment of the present invention；
Fig. 2 shows the application scenarios schematic diagrams of digital pathological section mask method provided by the embodiment of the present invention；
Fig. 3 shows user provided by the embodiment of the present invention and clicks the mark that mark icon is opened in the display interface
The schematic diagram of frame；
Fig. 4 shows showing for the markup information input dialogue frame popped up in the display interface provided by the embodiment of the present invention
It is intended to；
Fig. 5 shows a kind of structural schematic diagram of the annotation equipment of digital pathological section provided by the embodiment of the present invention.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention
Middle attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is only
It is a part of the embodiment of the present invention, instead of all the embodiments.The present invention being usually described and illustrated herein in the accompanying drawings is real
The component for applying example can be arranged and be designed with a variety of different configurations.Therefore, of the invention to what is provided in the accompanying drawings below
The detailed description of embodiment is not intended to limit the range of claimed invention, but is merely representative of selected reality of the invention
Apply example.Based on the embodiment of the present invention, those skilled in the art institute obtained without making creative work
There are other embodiments, shall fall within the protection scope of the present invention.
It is inconvenient in view of utilizing the notation methods of verbal description in the related technology and using the notation methods of region screenshot
Area to be studied is timely and accurately viewed in other users or user are subsequent, is unable to satisfy user study digital pathological section
Actual demand.Based on this, the embodiment of the invention provides a kind of mask method of digital pathological section and annotation equipment, below
It is described by embodiment.
As shown in Figure 1, the method comprising the steps of the embodiment of the invention provides a kind of method method of digital pathological section
S102-S106, specific as follows:
Step S102: the location information for the mark point that monitoring users are chosen on digital pathological section display interface and user
The mark graph style of selection, wherein above-mentioned digital pathological section is the number by obtaining after being scanned to pathological section
Image；
Wherein, above-mentioned mark point includes starting point, current point and the terminal that user chooses in the display interface, marks figure
Type is divided into regular figure and non-specification figure, and user clicks mark icon, that is, openable callout box, mark in the display interface
Various mark graph styles are shown in frame and mark the default color options for user selection of figure.
Furthermore it is also possible to include e-Pointer icon, when listening to user's click e-Pointer icon, the mark figure of drafting
Do not stored with markup information, can choose the mark figure for the drafting that disappeared after preset time automatically, or listen to exit it is glimmering
When light pen mode, the automatic mark figure removed on display interface, under fluorescence pen mode, suitable for temporarily marking the feelings of demonstration
Condition.
Step S104: according to the location information of above-mentioned mark point and above-mentioned mark graph style in above-mentioned digital pathological section
Mark figure is drawn on display interface；
Step S106: that above-mentioned user is inputted in predetermined input frame to be set with above-mentioned mark graphical association markup information
It is placed on above-mentioned display interface；Wherein, above-mentioned markup information includes at least one of: mark theme, marked content, mark figure
Shape color.
Wherein, the default color of above-mentioned mark figure and mark graphic color can be set to the color of default, can also be with
It is selected according to actual needs；Wherein, the default color of above-mentioned mark figure is drawn every time after referring to a certain particular color of selection
Using the color as default color when system mark figure, above-mentioned mark graphic color refers to can also be again when inputting marked content
Selection mark graphic color or it is subsequent to editor when can also reselect mark graphic color.
In the mask method of digital pathological section provided in an embodiment of the present invention, pass through figure labeling and information labeling phase
In conjunction with mode area to be studied is labeled in real time, realize the mode of multi-form mark, be conducive to other users or
User is subsequent timely and accurately to view area to be studied, meets the actual demand of user study digital pathological section.
Further, it is contemplated that the drafting mode of different labeled figure is different, above-mentioned location information according to mark point and
Above-mentioned mark graph style draws mark figure on above-mentioned digital pathological section display interface, comprising:
When the mark graph style that above-mentioned user selects is regular figure, with the initial point position letter in above-mentioned mark point
Point centered on the corresponding coordinate of breath, draws above-mentioned regular figure on above-mentioned digital pathological section display interface；
When the mark graph style that above-mentioned user selects is irregular shape, according to each point in above-mentioned mark point
The corresponding coordinate of confidence breath is adjacent two-by-two successively to draw straight line, draws on above-mentioned digital pathological section display interface closed
Irregular shape.
Specifically, point centered on the coordinate corresponding to the initial point position information in above-mentioned mark point, in above-mentioned number
Above-mentioned regular figure is drawn on pathological section display interface, comprising:
When the mark graph style that above-mentioned user selects is flag, with coordinate corresponding to initial point position information it is
Heart point draws flag figure on above-mentioned digital pathological section display interface；
When the mark graph style that above-mentioned user selects is rectangle, with coordinate corresponding to initial point position information it is
Heart point is for twice with the distance between coordinate corresponding to coordinate corresponding to initial point position information and end point location information
Diagonal line draws rectangular area on above-mentioned digital pathological section display interface；
When the mark graph style that above-mentioned user selects is round, with coordinate corresponding to initial point position information it is
Heart point, with the distance between coordinate corresponding to coordinate corresponding to initial point position information and end point location information for radius,
Border circular areas is drawn on above-mentioned digital pathological section display interface；
When the mark graph style that above-mentioned user selects is oval, with coordinate corresponding to initial point position information it is
Heart point, with twice of the distance between coordinate corresponding to coordinate corresponding to initial point position information and end point location information
To draw inner ellipse region on above-mentioned digital pathological section display interface in cornerwise rectangle.
Further, it is deposited to draw than being associated in mark figure and markup information asynchronous transmission to server
Storage, the relevant parameter listened to when due to consideration that drawing are to need to turn on parameter coordinate relative to display interface coordinate system
It is changed to and is stored again relative to the coordinate of digital pathological section, be based on this, the above method further include:
The above-mentioned markup information of the above-mentioned mark figure of drafting and setting is converted into the above-mentioned digital corresponding seat of case slice
Actual graphical parameter and practical markup information under mark system；
Store the corresponding relationship of above-mentioned digital case slice and above-mentioned actual graphical parameter and practical markup information, wherein
Above-mentioned actual graphical parameter includes at least one of the following: the upper left angle point phase of circumscribed rectangle corresponding to above-mentioned mark figure
For the coordinate of above-mentioned digital pathological section, drafting display multiplying power, the length of rectangle, the width of rectangle, circular radius, mark figure
The set of the area of shape and the coordinate points listened to.
Wherein, if the length of rectangle, the width of rectangle, circular radius, that is, point-to-point transmission distance are to obtain in the following way
:
The pixel distance of starting point and terminal is obtained according to the location information of the starting point of one section of line segment and terminal, comprising:
According to calculation formula
Starting point and terminal is calculated in B=parseInt (Math.sqrt (squer (x2-x1)+squer (y2-y1)))
Pixel distance, wherein (x1, y1) be starting point coordinate, (x2, y2) be terminal coordinate, B be starting point and terminal picture
Plain distance, parseInt are bracket function, and Math.sqrt is evolution function, and squer is squared function；
According to the conversion of starting point corresponding with the pixel distance of terminal and display interface pixel distance and actual range
Formula determines the actual range of starting point and terminal, comprising:
It is public according to the conversion of starting point pixel distance corresponding with the pixel distance of terminal and display interface and actual range
FormulaThe actual range of starting point and terminal is calculated, wherein A is the actual range of starting point and terminal,
B is the pixel distance of starting point and terminal, and a is the actual range of physics pathological section, and b is the number disease under maximum scan multiplying power
The pixel wide of slice is managed, rate is maximum scan multiplying power, and clay is current display multiplying power.
Specifically, the above-mentioned markup information of the above-mentioned mark figure of drafting and setting is converted to above-mentioned digital case slice
Actual graphical parameter and practical markup information under respective coordinates system, comprising:
Determine coordinate of the upper left angle point of circumscribed rectangle corresponding to above-mentioned mark figure relative to display interface；
According to reduction formula Bx=Px+LxAnd By=Py+LyBy the upper left angle point of above-mentioned circumscribed rectangle relative to display interface
Coordinate transformation be coordinate relative to above-mentioned digital pathological section, wherein (Px, Py) be circumscribed rectangle upper left angle point it is opposite
In the coordinate of display interface, (Bx, By) it is the coordinate that the upper left angle point of circumscribed rectangle is sliced relative to digital case, (Lx, Ly) be
Draw offset of the digital case slicing edge relative to display interface under display multiplying power.
Wherein, LxAnd LyIt is by formula Lx=Mx*zoom*NxAnd Ly=My*zoom*Ny, M in formulaxAnd MyIndicate display
The length and width at interface, NxAnd NyIndicate that digital pathological section (contains x, the two coordinate sides y relative to the boundary of display interface
To), zoom indicates the ratio of digital pathological section width and display interface width.
Circumscribed rectangle corresponding to above-mentioned mark figure refers to a rectangular region just comprising mark figure, for
For irregular figure, marks circumscribed rectangle corresponding to figure and refer to, obtained with the y-axis difference of Y-axis highs and lows
Height is the width of rectangle, length, that is, rectangle length is obtained with the most left and most right x-axis difference of X-axis, according to the width and length
Degree obtains the rectangle tab area that may include all point sets.
In embodiment provided by the invention, before storing graphic parameter and markup information, when need to will draw mark figure
The coordinate of the acquired parameter relative to display interface is converted to the coordinate of the parameter relative to digital pathological section, general feelings
Under condition, since above-mentioned either regular figure or irregular figure all correspond to a circumscribed rectangle, by the circumscribed rectangle
Upper left angle point as anchor point, and the anchor point is converted into the coordinate value under digital case slice coordinates system and is stored,
It is influenced during subsequent display by display position, to show accurately parameter coordinate.
Further, it is contemplated that display may be zoomed in and out when subsequent display, to digital pathological section image in order to make to mark
Note figure, which synchronizes, to be zoomed in and out, and is based on this, the above method further include:
Obtain the current display multiplying power of above-mentioned digital pathological section, the above-mentioned actual graphical parameter of storage and practical mark letter
Breath；
The above-mentioned actual graphical parameter of storage and above-mentioned practical markup information are converted to according to above-mentioned current display multiplying power
Display graphic parameter and display markup information under above-mentioned display interface respective coordinates system；
Currently display multiplying power under, shown on the display interface of above-mentioned digital pathological section above-mentioned display graphic parameter and
Show markup information, wherein display graphic parameter includes current display multiplying power, the length of rectangle, the width of rectangle, round half
Diameter, the area for marking figure etc., are particularly shown which parameter can be shown according to actual needs, and can also will join
Several numerical value is shown with micron value.
Specifically, according to above-mentioned current display multiplying power by the above-mentioned actual graphical parameter of storage and above-mentioned practical markup information
Be converted to the display graphic parameter and display markup information under above-mentioned display interface respective coordinates system, comprising:
According to formulaBy the above-mentioned actual graphical parameter of storage and above-mentioned practical markup information be scaled with
The above-mentioned current actual graphical parameter that matches of display multiplying power and practical markup information, wherein A is and currently shows multiplying power phase
Perhaps practical markup information a is the actual graphical parameter of storage to the actual graphical parameter matched or practical markup information, clay are
Current display multiplying power, γ are to draw display multiplying power；
According to reduction formula Cx=Ax+ηxAnd Cy=Ay+ηyThe actual graphical to match with above-mentioned current display multiplying power is joined
Several and practical markup information is scaled display graphic parameter and display markup information relative to above-mentioned display interface, wherein
(Ax, Ay) it is the coordinate of actual graphical parameter or practical markup information relative to digital pathological section, (Cx, Cy) it is practical figure
The coordinate of shape parameter or practical markup information relative to display interface, (ηx, ηy) it is digital case slice under current display multiplying power
Offset of the edge relative to display interface.
Wherein, above-mentioned current display multiplying power obtains as follows:
Current display multiplying power is determined using formula clay/rate=sm/wd, wherein clay indicates digital pathological section
Current display multiplying power, rate indicate the maximum scan multiplying power of digital pathological section, and sm indicates the corresponding scaling times of digital pathological section
The pixel wide value of rate, wd indicate that digital pathological section corresponds to the pixel wide value of maximum scan multiplying power.
It, first will be with the actual graphical parameter and reality of storage according to current display multiplying power in embodiment provided by the invention
Border markup information is scaled graphic parameter and markup information under currently display multiplying power, then, by the graphic parameter after conversion
Carry out coordinate system conversion with markup information, by graphic parameter and markup information by relative to digital pathological section be converted to relative to
Display interface, then shown, realizing makes to mark figure scales on year-on-year basis with digital pathological section image, thus in Zoom display
In the case where make mark figure positioning it is more accurate.
The application scenarios of the mask method of digital pathological section as shown in Figure 2, in the application scenarios, first with cutting
Piece scanner 32 scans physics slice 31, obtains digital pathological section, is then carried out using server 33 to digital pathological section
It is classified piecemeal storage and image logic processing, the corresponding image data of digital pathological section is finally inputted into display terminal 34, is led to
It crosses display terminal 34 and shows digital pathological section, user is by clicking the mark icon 341 on display terminal 34, in open mark
Selection mark graph style and mark graphic color draw mark figure on display terminal 34 in real time and input mark in note frame
Information etc. draws the mark figure of an oval shape on the digital pathological section figure being displayed on the display interface in figure.
The schematic diagram that user clicks the callout box that mark icon is opened in the display interface, mark are given as shown in Figure 3
Various mark graph styles are shown in note frame and mark the default color options for user selection of figure.
Give the schematic diagram of the markup information input dialogue frame popped up in the display interface as shown in Figure 4, user can be with
The mark theme and marked content of input and mark graphical association, while mark graphic color can be reselected.
In the case where drawing multiple marks in a digital pathological section, it can be opened in the sidebar of display interface
Show annotation list, the mark figure and markup information for needing to check can be randomly selected in user, remaining mark is not shown；Together
When, a parameter also can be set and show option, the parameter type of display for selection, unchecked parameter is not shown.
In digital pathological section mask method provided by the invention, the side that is combined by figure labeling with information labeling
Formula is in real time labeled area to be studied, realizes the mode of multi-form mark, is conducive to other users or user is subsequent
Area to be studied is timely and accurately viewed, the actual demand of user study digital pathological section is met；Further, it stores
Before graphic parameter and markup information, the coordinate of the parameter relative to display interface acquired when drawing mark figure is converted
Coordinate for the parameter relative to digital pathological section is stored again, realizes accurately display parameters coordinate；Further
, it will be scaled first with the actual graphical parameter of storage and practical markup information in current display times according to current display multiplying power
Then graphic parameter and markup information under rate by the graphic parameter and markup information progress coordinate system conversion after conversion, will scheme
Shape parameter and markup information relative to digital pathological section by being converted to relative to display interface, then is shown, realizing makes
Mark figure scales on year-on-year basis with digital pathological section image, to make mark figure positioning more quasi- in the case where Zoom display
Really.
Corresponding to above-mentioned mask method, the embodiment of the invention also provides a kind of annotation equipments of digital pathological section, such as
Shown in Fig. 5, the apparatus may include:
Module 502 is monitored, the position letter for the mark point that monitoring users are chosen on digital pathological section display interface
The mark graph style of breath and user's selection, wherein above-mentioned digital pathological section is by obtaining after being scanned to pathological section
The digital picture obtained；
Graphic plotting module 504 is marked, for existing according to the location information and above-mentioned mark graph style of above-mentioned mark point
Mark figure is drawn on above-mentioned digital pathological section display interface；
Markup information setup module 506, for inputting above-mentioned user in predetermined input frame with above-mentioned mark figure
Associated markup information is set on above-mentioned display interface；Wherein, above-mentioned markup information includes at least one of: mark master
Topic, marked content, mark graphic color.
Further, above-mentioned apparatus further include:
First conversion module, for the above-mentioned markup information of the above-mentioned mark figure drawn and setting to be converted to above-mentioned number
Word case is sliced actual graphical parameter and practical markup information under respective coordinates system；
Memory module, for storing pair of above-mentioned digital case slice and above-mentioned actual graphical parameter and practical markup information
It should be related to, wherein above-mentioned actual graphical parameter includes at least one of the following: circumscribed rectangle corresponding to above-mentioned mark figure
Upper left angle point relative to above-mentioned digital pathological section coordinate, draw display multiplying power, the length of rectangle, the width of rectangle, circle
The set of shape radius and the coordinate points listened to.
Further, above-mentioned apparatus further include:
Module is obtained, for obtaining current display multiplying power, the above-mentioned actual graphical of the storage ginseng of above-mentioned digital pathological section
Several and practical markup information；
Second conversion module, for according to above-mentioned current display multiplying power by the above-mentioned actual graphical parameter of storage and above-mentioned reality
Border markup information is converted to display graphic parameter and display markup information under above-mentioned display interface respective coordinates system；
Display module, for being shown on the display interface of above-mentioned digital pathological section above-mentioned under currently display multiplying power
Show graphic parameter and display markup information.
Based on above-mentioned analysis it is found that the annotation equipment of digital pathological section provided in an embodiment of the present invention passes through figure labeling
The mode combined with information labeling is in real time labeled area to be studied, realizes the mode of multi-form mark, is conducive to
Other users or user is subsequent timely and accurately views area to be studied, meet the reality of user study digital pathological section
Border demand；Further, it before storing graphic parameter and markup information, will draw acquired relative to display when marking figure
The coordinate that the coordinate of the parameter at interface is converted to the parameter relative to digital pathological section is stored again, is realized and is accurately shown
Show parameter coordinate；It further, first will be with the actual graphical parameter of storage and practical mark letter according to current display multiplying power
Breath is scaled graphic parameter and markup information under currently display multiplying power, and then, the graphic parameter after conversion is believed with mark
Breath carries out coordinate system conversion, by graphic parameter and markup information by being converted to relative to digital pathological section relative to display circle
Face, then shown, realizing makes to mark figure scales on year-on-year basis with digital pathological section image, thus the Zoom display the case where
Under make mark figure positioning it is more accurate.
The annotation equipment of digital pathological section provided by the embodiment of the present invention can in equipment specific hardware or
Software or firmware for being installed in equipment etc..The technology of device provided by the embodiment of the present invention, realization principle and generation is imitated
Fruit is identical with preceding method embodiment, and to briefly describe, Installation practice part does not refer to place, can refer to preceding method implementation
Corresponding contents in example.It is apparent to those skilled in the art that for convenience and simplicity of description, foregoing description
The specific work process of system, device and unit, the corresponding process during reference can be made to the above method embodiment, it is no longer superfluous herein
It states.
In embodiment provided by the present invention, it should be understood that disclosed device and method, it can be by others side
Formula is realized.The apparatus embodiments described above are merely exemplary, for example, the division of the unit, only one kind are patrolled
Function division is collected, there may be another division manner in actual implementation, in another example, multiple units or components can combine or can
To be integrated into another system, or some features can be ignored or not executed.Another point, shown or discussed is mutual
Coupling, direct-coupling or communication connection can be INDIRECT COUPLING or communication link by some communication interfaces, device or unit
It connects, can be electrical property, mechanical or other forms.
The unit as illustrated by the separation member may or may not be physically separated, aobvious as unit
The component shown may or may not be physical unit, it can and it is in one place, or may be distributed over multiple
In network unit.It can select some or all of unit therein according to the actual needs to realize the mesh of this embodiment scheme
's.
In addition, each functional unit in embodiment provided by the invention can integrate in one processing unit, it can also
To be that each unit physically exists alone, can also be integrated in one unit with two or more units.
It, can be with if the function is realized in the form of SFU software functional unit and when sold or used as an independent product
It is stored in a computer readable storage medium.Based on this understanding, technical solution of the present invention is substantially in other words
The part of the part that contributes to existing technology or the technical solution can be embodied in the form of software products, the meter
Calculation machine software product is stored in a storage medium, including some instructions are used so that a computer equipment (can be a
People's computer, server or network equipment etc.) it performs all or part of the steps of the method described in the various embodiments of the present invention.
And storage medium above-mentioned includes: that USB flash disk, mobile hard disk, read-only memory (ROM, Read-Only Memory), arbitrary access are deposited
The various media that can store program code such as reservoir (RAM, Random Access Memory), magnetic or disk.
It should also be noted that similar label and letter indicate similar terms in following attached drawing, therefore, once a certain Xiang Yi
It is defined in a attached drawing, does not then need that it is further defined and explained in subsequent attached drawing, in addition, term " the
One ", " second ", " third " etc. are only used for distinguishing description, are not understood to indicate or imply relative importance.
Finally, it should be noted that embodiment described above, only a specific embodiment of the invention, to illustrate the present invention
Technical solution, rather than its limitations, scope of protection of the present invention is not limited thereto, although with reference to the foregoing embodiments to this hair
It is bright to be described in detail, those skilled in the art should understand that: anyone skilled in the art
In the technical scope disclosed by the present invention, it can still modify to technical solution documented by previous embodiment or can be light
It is readily conceivable that variation or equivalent replacement of some of the technical features；And these modifications, variation or replacement, do not make
The essence of corresponding technical solution is detached from the spirit and scope of technical solution of the embodiment of the present invention.Should all it cover in protection of the invention
Within the scope of.Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (7)
1. a kind of mask method of digital pathological section characterized by comprising monitoring users show boundary in digital pathological section
The location information for the mark point chosen on face and the mark graph style of user's selection, wherein the digital pathological section is logical
Cross the digital picture obtained after being scanned to pathological section；
It is drawn on the digital pathological section display interface according to the location information of the mark point and the mark graph style
System mark figure；
It is that the user is inputted in predetermined input frame to be set to the display with mark graphical association markup information
On interface；Wherein, the markup information includes at least one of: mark theme, marked content, mark graphic color；
The markup information of the mark figure of drafting and setting is converted into digital pathological section respective coordinates system
Under actual graphical parameter and practical markup information；
Store the corresponding relationship of the digital pathological section Yu the actual graphical parameter and practical markup information, wherein described
Actual graphical parameter includes at least one of the following: it is described mark figure corresponding to circumscribed rectangle upper left angle point relative to
The coordinate of the digital pathological section is drawn display multiplying power, the length of rectangle, the width of rectangle, circular radius and is listened to
Coordinate points set；
Wherein, the markup information by the mark figure of drafting and setting is converted to the digital pathological section pair
Answer the actual graphical parameter under coordinate system and practical markup information, comprising:
Determine coordinate of the upper left angle point of circumscribed rectangle corresponding to the mark figure relative to display interface；
According to reduction formula Bx=Px+LxAnd By=Py+LySeat by the upper left angle point of the circumscribed rectangle relative to display interface
Subscript conversion is the coordinate relative to the digital pathological section, wherein (Px, Py) it is the upper left angle point of circumscribed rectangle relative to aobvious
Show the coordinate at interface, (Bx, By) it is coordinate of the upper left angle point of circumscribed rectangle relative to digital pathological section, (Lx, Ly) it is to draw
Show offset of the digital pathological section edge relative to display interface under multiplying power.
2. the mask method of digital pathological section according to claim 1, which is characterized in that described according to the mark point
Location information and the mark graph style drawn on the digital pathological section display interface mark figure, comprising:
When the mark graph style that the user selects is regular figure, with the initial point position information institute in the mark point
Point centered on corresponding coordinate draws the regular figure on the digital pathological section display interface；
When the mark graph style that the user selects is irregular shape, according to each point confidence in the mark point
The corresponding coordinate of breath is adjacent two-by-two successively to draw straight line, draws and closed does not advise on the digital pathological section display interface
Then shape.
3. the mask method of digital pathological section according to claim 2, which is characterized in that with rising in the mark point
Point centered on coordinate corresponding to initial point location information draws the rule schema on the digital pathological section display interface
Shape, comprising:
When the mark graph style that the user selects is flag, centered on the coordinate corresponding to the initial point position information
Point draws flag figure on the digital pathological section display interface；
When the mark graph style that the user selects is rectangle, centered on the coordinate corresponding to the initial point position information
Point is pair with twice of the distance between coordinate corresponding to coordinate corresponding to initial point position information and end point location information
Linea angulata draws rectangular area on the digital pathological section display interface；
When the mark graph style that the user selects is round, centered on the coordinate corresponding to the initial point position information
Point, with the distance between coordinate corresponding to coordinate corresponding to initial point position information and end point location information for radius,
Border circular areas is drawn on the digital pathological section display interface；
When the mark graph style that the user selects is oval, centered on the coordinate corresponding to the initial point position information
Point is being with twice of the distance between coordinate corresponding to coordinate corresponding to initial point position information and end point location information
In cornerwise rectangle, inner ellipse region is drawn on the digital pathological section display interface.
4. the mask method of digital pathological section according to claim 1, which is characterized in that the method also includes:
Obtain the current display multiplying power of the digital pathological section, the actual graphical parameter of storage and practical markup information；
The actual graphical parameter of storage and the practical markup information be converted to according to the current display multiplying power described
Display graphic parameter and display markup information under display interface respective coordinates system；
Under currently display multiplying power, the display graphic parameter and display are shown on the display interface of the digital pathological section
Markup information.
5. the mask method of digital pathological section according to claim 4, which is characterized in that according to the current display times
Rate is converted to the actual graphical parameter of storage and the practical markup information under display interface respective coordinates system
Show graphic parameter and display markup information, comprising:
According to formulaBy the actual graphical parameter of storage and the practical markup information be scaled with it is described
The actual graphical parameter and practical markup information that current display multiplying power matches, wherein A matches with current display multiplying power
Perhaps practical markup information a is the actual graphical parameter of storage to actual graphical parameter or practical markup information, clay are current
Show multiplying power, γ is to draw display multiplying power；
According to reduction formula Cx=Ax+ηxAnd Cy=Ay+ηyBy with the current actual graphical parameter that matches of display multiplying power and
Practical markup information is scaled display graphic parameter and display markup information relative to the display interface, wherein (Ax, Ay)
Coordinate for actual graphical parameter or practical markup information relative to digital pathological section, (Cx, Cy) be actual graphical parameter or
Coordinate of the practical markup information of person relative to display interface, (ηx, ηy) it is that digital pathological section edge is opposite under current display multiplying power
In the offset of display interface.
6. a kind of annotation equipment of digital pathological section characterized by comprising
Module is monitored, the location information for marking point chosen on digital pathological section display interface for monitoring users and user
The mark graph style of selection, wherein the digital pathological section is the number by obtaining after being scanned to pathological section
Image；
Graphic plotting module is marked, for the location information and the mark graph style according to the mark point in the number
Mark figure is drawn on pathological section display interface；
Markup information setup module, the mark with the mark graphical association for inputting the user in predetermined input frame
Note information is set on the display interface；Wherein, the markup information includes at least one of: in mark theme, mark
Hold, mark graphic color；
First conversion module, for the markup information of the mark figure drawn and setting to be converted to the number disease
Actual graphical parameter and practical markup information under reason slice respective coordinates system；
Memory module, for storing the corresponding pass of the digital pathological section with the actual graphical parameter and practical markup information
System, wherein the actual graphical parameter includes at least one of the following a: left side for circumscribed rectangle corresponding to the mark figure
Upper angle point is relative to the coordinate of the digital pathological section, drafting display multiplying power, the length of rectangle, the width of rectangle, round half
The set of diameter and the coordinate points listened to；
Wherein, first conversion module, is specifically used for:
Determine coordinate of the upper left angle point of circumscribed rectangle corresponding to the mark figure relative to display interface；
According to reduction formula Bx=Px+LxAnd By=Py+LySeat by the upper left angle point of the circumscribed rectangle relative to display interface
Subscript conversion is the coordinate relative to the digital pathological section, wherein (Px, Py) it is the upper left angle point of circumscribed rectangle relative to aobvious
Show the coordinate at interface, (Bx, By) it is coordinate of the upper left angle point of circumscribed rectangle relative to digital pathological section, (Lx, Ly) it is to draw
Show offset of the digital pathological section edge relative to display interface under multiplying power.
7. the annotation equipment of digital pathological section according to claim 6, which is characterized in that described device further include:
Obtain module, for obtain the current display multiplying power of the digital pathological section, the actual graphical parameter of storage and
Practical markup information；
Second conversion module, for being marked the actual graphical parameter of storage and the reality according to the current display multiplying power
Note information is converted to display graphic parameter and display markup information under display interface respective coordinates system；
Display module, for showing the display on the display interface of the digital pathological section under currently display multiplying power
Graphic parameter and display markup information.
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| CN107220499B (en) * | 2017-05-26 | 2021-04-13 | 粉蓝医疗科技（杭州）有限公司 | Slice file storage method and device |
| CN107273698B (en) * | 2017-07-06 | 2020-03-27 | 北京大学人民医院 | Processing and detecting method and system for artificial intelligence training standard library |
| CN107516005A (en) * | 2017-07-14 | 2017-12-26 | 上海交通大学 | A kind of method and system of digital pathological image mark |
| CN107491660A (en) * | 2017-09-29 | 2017-12-19 | 北京华信佳音医疗科技发展有限责任公司 | Lesion image pre-processing method and system |
| CN108682453A (en) * | 2018-05-16 | 2018-10-19 | 四川大学 | A kind of Lung neoplasm labeling system |
| CN109215017B (en) * | 2018-08-16 | 2020-06-02 | 腾讯科技（深圳）有限公司 | Picture processing method and device, user terminal, server and storage medium |
| CN109378052B (en) * | 2018-08-31 | 2019-07-30 | 透彻影像(北京)科技有限公司 | The preprocess method and system of image labeling |
| CN109492635A (en) * | 2018-09-20 | 2019-03-19 | 第四范式（北京）技术有限公司 | Obtain method, apparatus, equipment and the storage medium of labeled data |
| JP7252729B2 (en) * | 2018-10-18 | 2023-04-05 | キヤノン株式会社 | Image processing device, image processing method |
| CN111857893A (en) * | 2019-04-08 | 2020-10-30 | 百度在线网络技术（北京）有限公司 | Method and device for generating label graph |
| CN110989905A (en) * | 2019-12-18 | 2020-04-10 | 深圳市商汤科技有限公司 | Information processing method and device, electronic equipment and storage medium |
| CN111324761B (en) * | 2020-02-25 | 2023-10-13 | 平安科技（深圳）有限公司 | Image annotation management method, device, computer system and readable storage medium |
| WO2021217543A1 (en) * | 2020-04-30 | 2021-11-04 | 华为技术有限公司 | Image annotation method, apparatus, device and medium |
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