CN105597234B - Multilayer bias figure-eight coil for deep position transcranial magnetic stimulation - Google Patents
Multilayer bias figure-eight coil for deep position transcranial magnetic stimulation Download PDFInfo
- Publication number
- CN105597234B CN105597234B CN201510398375.2A CN201510398375A CN105597234B CN 105597234 B CN105597234 B CN 105597234B CN 201510398375 A CN201510398375 A CN 201510398375A CN 105597234 B CN105597234 B CN 105597234B
- Authority
- CN
- China
- Prior art keywords
- coil
- deep position
- induction field
- field
- layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Magnetic Treatment Devices (AREA)
Abstract
For the multilayer bias figure-eight coil of deep position transcranial magnetic stimulation, using multi-tier arrangement coil, first layer formation base figure-eight coil, below each layer line circle it is symmetrical along figure-eight coil center line, adjust magnetic field and induction field.The distance of each layer coil centerline and symmetry axis determines that the target of optimization is to make induction field E (z0) caused by coil surface and deep position induction field E (z) ratios minimum by optimization method.Each layer line circle can be arranged at grade, can also intersect angled.When the present invention reaches threshold potential in deep position, coil surface induction field is in the scope of safety, and has good focusing in deep position.The multilayer bias figure-eight coil that the present invention obtains approaches even better than H coils along depth direction induction field decay indices.
Description
Technical field
The invention belongs to transcranial magnetic stimulation field, more particularly to a kind of multilayer bias 8 for deep position transcranial magnetic stimulation
Font coil.
Background technology
Transcranial magnetic stimulation (Transcranial Magnetic Stimulation, TMS) is to utilize time-varying pulse electromagnetic field
Caused induction field acts on cerebral central nervous system, changes the film potential of Neurons of Cerebral Cortex, influences intracerebral generation
Thank with neural electrical activity, so as to cause a series of a kind of cerebral nerve art treatments method of biochemical reactions.TMS is by Britain
The scholar such as Barker founded first in 1985, there is painless, not damaged, without x-ray radiation.With computer technology
Development, TMS and repetitive transcranial magnetic stimulation technology (Repeated TMS, rTMS) are in Cognitive Neuroscience, clinical nerve essence
Refreshing disease and rehabilitation field obtain increasing accreditation.Israel's approval in 2002 enters clinical practice, U.S.'s food in 2008
Thing is ratified to be used in antiradiation drug refractory depression with drug administration (FDA).Chinese [2002] No. 302 approval warps of traditional Chinese medicines prison tool
Cranium magnetic stimulator is II class medical electronic apparatus equipment.
Transcranial magnetic stimulation equipment is mainly made up of high-voltage pulse electric source generator, stimulating coil and control computer.Its work
It is as principle：Control computer sends charge/discharge instruction to high-voltage pulse electric source generator；High-voltage pulse power source is sent out during charging
Raw device charges to internal storage capacitor；Storage capacitor discharges stimulating coil during electric discharge, produces pulsed magnetic field, acts on brain,
Induction field is produced, acts on brain neuroblastoma cell, nerve cell electrophysiological characteristics is stimulated, reaches therapeutic purposes.
Stimulating coil determines the pulsed magnetic field characteristic of TMS equipment, and further determines the cerebral nerve zone of action
Induction field characteristic.Current TMS equipment based on plane 8-shaped and circular coil, stimulate depth generally coil surface with
Lower 20~25mm.Because the stimulating coil used in clinical at present is shallower, generally within 25mm, can not stimulate corticocerebral
Deep trench position, hippocampus etc. inside cerebral cortex can not be more stimulated to organize, the clinic for limiting transcranial magnetic stimulation should
With the scope of indication.Current TMS technology status is made a general survey of, the bottleneck of deep position transcranial magnetic stimulation does not lie in high-voltage pulse power source
Part, but it is no practical deep position magnetic stimulating coil, therefore TMS industries need deep position magnetic stimulating coil badly.
For the magnetic stimulating coil of deep position, (it is usually when induction field caused by the position of deep reaches threshold potential in film
20~60V/m, Y.Roth etc.J.Clinical Neurophysiol, vol.19, pp.361-370,2002) when, coil
Surface induction electric field can be very high, for example, when more than 300V/m, consequence caused by too high induction field value is exactly patient in head
Skin zone position produces tingling sensation, makes one to bear, or even can bring injury, therefore deep position magnetic stimulating coil designs what is solved
Key problem is that the ratio of induction field caused by coil surface and deep position induction field is small as much as possible, weighs deep position magnetic
For the index of stimulating coil with ratio Ez (x)/Ez (z0), ratio Ez (x)/Ez (z0) is bigger, illustrates induction field with depth attenuation
It is smaller.Ez (x) is the induction field that depth is at x millimeters under coil, and Ez (z0) is the sense that depth is at z0 millimeters under coil
Answer electric field, z0 value is 10mm or 5mm, the reference data as depth direction.
Induction field and deep position induced electricity caused by plane 8-shaped and circular coil coil surface used in clinical at present
The ratio of field is more than 6.5 times (by taking 50mm as an example), and surface field value is much larger than 300V/m, therefore is not suitable as deep Neural stem cell
Coil uses.A kind of biconial coil (double-cone coil) is as the improvement to figure-eight coil, for 30~40mm's
Deep position Neural stem cell.Biconial coil there is also with depth attenuation it is too fast the problem of, for example, to realize under coil 50V/ at 50mm
M induction field intensity, the induction field intensity under coil at 10mm is about 500V/m, and this will be difficult to bear.With color
The Yiftach Roth of row proposed H coils (Hesed coil) structure in 2002, and induction field is decayed in the depth direction
It is significantly less than figure-eight coil, is the deep position magnetic stimulating coil organization plan more approved at present.
The content of the invention
The present invention proposes a kind of multilayer bias figure-eight coil for deep position transcranial magnetic stimulation, produces coil surface
Induction field and deep position induction field ratio it is smaller, when deep position reaches threshold potential, coil surface induction field is in
In the scope of safety.
The present invention adopts the following technical scheme that：
For the multilayer bias figure-eight coil of deep position transcranial magnetic stimulation, it is made up of n (n >=2) layer line circle, folds vertically
Add, a pair of coils of the superiors are tangent, form basic figure-eight coil, produce basic magnetic field and induction field；With basic 8-shaped
The tangent line of coil is symmetry axis, and the coil of lower floor occurs in pairs；The distance of each layer coil central axe and symmetry axis is according to excellent below
Change method determines, below the effect of each layer line circle be regulation magnetic field and induction field, meet deep position Neural stem cell E (z0)/E (z)
Small requirement as far as possible.
The optimization method for determining inner coil center is：
Object function：min E(z0)/E(z)
Constraints：lb(r2, r3..., rn)≤(r2, r3..., rn)≤ub(r2, r3..., rn)
In formula, it is induction field on figure-eight coil center line at z0 away from orlop coil depth that E (z0), which is, E (z)
To be the induction field on the figure-eight coil center line at z away from orlop coil depth, E (z0)/E (z) is the ratio of the two,
The target of optimization is to make E (z0)/E (z) minimum；Optimized variable is (r2, r3..., rn), r2, r3..., rnFor inner coil 2, line
Circle 3 ..., coil n center line are to the distance of 8-shaped center line, lb (r2, r3..., rn) kind ub (r2, r3..., rn) be respectively under
Boundary condition and upper boundary conditions.
The present invention is used for the multilayer bias figure-eight coil of deep position transcranial magnetic stimulation, is characterized in：Multi-tier arrangement coil；The
One layer of formation base figure-eight coil；Each layer line circle is symmetrical along figure-eight coil center line below, each layer coil centerline with
The distance of symmetry axis is determined by optimization method.Each layer line circle can be arranged at grade, can also intersect certain angle
Degree.The coil arrangement and optimization method that the present invention mentions can be not only used for deep position tms coil, can also use
In the coil of other particular field shapes requirement.
Brief description of the drawings
Fig. 1 is the multilayer bias figure-eight coil structure chart for deep position transcranial magnetic stimulation.Definition is as illustrated in the drawing
Xyz rectangular coordinate system in space, the origin of coordinates are the point of contact center of coil 1 and coil 1 ', and xoy planes are coil plane, and z-axis is vertical
In coil plane.Whole coil block is made up of six subcoils in figure, respectively coil 1, coil 2 and coil 3, coil 1 ',
Coil 2 ' and coil 3 '；Coil 1, coil 2 and coil 3 are one group, are divided into three layers along the z-axis direction, coil 2 in the lower section of coil 1,
Coil 3 is in the lower section of coil 2, and coil 1, coil 2 are parallel with the central shaft of coil 3 and y-coordinate is identical, and x coordinate is different, three lines
The logical same direction current of circle；Coil 1 ', coil 2 ' and coil 3 ' are another group, and the line centered on z-axis is coil 1 ', right in the x direction
Claim, electrical current direction is opposite with coil 1, coil 2 and the sense of current of coil 3.
Fig. 2 denotes the coil parameter to be optimized according to Fig. 1 coil space coordinate definition.R2, R3 are coil 2, line
Enclose 3 center lines to z-axis distance, (R2, R3) be the parameter to be optimized；Site P0, Px is located in z-axis, and P0 is electric field datum mark, is arrived
Initial point distance is Z0, and Px is deep position target electric Field Calculation point, is Zx to initial point distance.
Fig. 3 is the model calculated for piezomagnetic theory, and induction field Calculation Plane and the distance of coil lower surface are
Zp, induction field zoning is in xoy planes.
Fig. 4 is under Fig. 3 computation model, and induction field is distributed in zoning during Zp=10mm, and Fig. 5 is corresponding sense
Answer electric field pattern of equipotentials.
Fig. 7 is under Fig. 3 computation model, and magnetic field is distributed in zoning during Zp=50mm, Fig. 8 piezomagnetic theories,
Fig. 6 is corresponding induction field pattern of equipotentials.
Fig. 9 is multilayer off-centred coil, figure-eight coil, E (z0)/E (z) comparison diagrams of H coils that the present invention designs.
Figure 10 be it is of the invention another implement illustration, left and right coil is into certain angle of cut α.
Embodiment
The present invention is further illustrated below in conjunction with the drawings and the specific embodiments.
Fig. 1 is the multilayer bias figure-eight coil structure chart for deep position transcranial magnetic stimulation.In embodiments of the invention,
For the ease of contrast, more figure-eight coil sized divisions are used at present, coil 1, coil 2 and coil 3 are defined as.Coil
1 ', coil 2 ' and the size of coil 3 ' are identical with the size of coil 1, coil 2 and coil 3, symmetrical on z-axis, lead to reverse current.
The conductor size that embodiment uses for：High × wide 3mm × 1.5mm；
Figure-eight coil size as a comparison：Inside radius × outer radius 22.5mm × 45mm, totally 15 circle；
The present embodiment is three layer line circles arrangement, and figure-eight coil is divided into three coils according to radius, the wire of consuming with
Figure-eight coil is identical, and each layer coil dimension is as follows：
Coil 1：Inside radius × outer radius 37.5mm × 45mm, totally 5 circle, positioned at the superiors；
Coil 2：Inside radius × outer radius 30mm × 37.5mm, totally 5 circle, positioned at most intermediate layer；
Coil 3：Inside radius × outer radius 22.5mm × 30mm, totally 5 circle, positioned at orlop；
Each layer closely stacks, and coil 1 and coil 1 ' are tangential on z-axis, the 8-shaped that partners basis coil.
Fig. 2 further defines optimized variable on the basis of Fig. 1.R2, R3 be coil 2, the center line of coil 3 to z-axis away from
From (R2, R3) is the parameter to be optimized；Site P0, Px is located in z-axis, and P0 is electric field datum mark, is Z0=to initial point distance
10mm, Px are deep position target electric Field Calculation point, are Zx=50mm to initial point distance.Determine inner coil center (R2,
R3 optimization method) is：
Object function：min E(Z0)/E(Zx)
Constraints：Lb (0,0)≤(R2, R3)≤ub (0.18,0.18)
E (Z0) is the induction field at P0, and E (Zx) is induction field at Px, and the target of optimization is to make E (Z0)/E (Zx) most
It is small；Coil 2, coil 3, the distance change of center line to z-axis is 0~0.18m, thus may determine that downstream condition lb (0,0)
With upper boundary conditions ub (0.18,0.18).This is non-Linearly constrained problem, and (R2, R3) value is obtained using matlab solvers
For (0.0913,0.0847), unit is rice.
The piezomagnetic theory for obtaining coil to solution using the model shown in Fig. 3 calculates checking.Represented with spherical
Head model, calculates piezomagnetic theory in the xoy planes under coil plane at Zp, and value is：X ∈ (- 0.2 ,+0.2), y ∈
(- 0.2 ,+0.2).
Assuming that peak point current is 3500 amperes, the microsecond of rise time 50, according to obtained coil parameter, coil is calculated
Piezomagnetic theory at lower 10mm is as shown in figure 4, electric field pattern of equipotentials is as shown in Figure 5, it can be seen that has three focuses, senses
Peak electric field is 191V/m, in the scope in safety.Fig. 7 is the Distribution of Magnetic Field at 50mm under coil, and Fig. 8 senses to be corresponding
Electric Field Distribution, Fig. 6 are corresponding electric field pattern of equipotentials, it can be seen that an only focus, induction field peak value is 65V/m.
Fig. 9 is that the multilayer off-centred coil that the embodiment of the present invention obtains declines with figure-eight coil, H coils along depth direction electric field
Subtract E (z)/E (z0) contrast.As can be seen that the multilayer bias figure-eight coil that the present invention is used for deep position transcranial magnetic stimulation is obvious
Better than the figure-eight coil of routine, even better than H coils.Wherein, the data source of H coils is in paper Y.Roth
Fig.6 in etc.J.Clinical Neurophysiol, vol.19, pp.361-370,2002.
The multilayer bias figure-eight coil structure that the present invention is used for deep position transcranial magnetic stimulation is not limited to planar coil construction,
Coil is to that can also intersect angled α, as shown in Figure 10.
Claims (1)
1. the multilayer bias figure-eight coil for deep position transcranial magnetic stimulation, it is characterised in that it is made up of n (n >=2) layer line circle,
It is superimposed vertically, a pair of coils of the superiors are tangent, form basic figure-eight coil, produce basic magnetic field and induction field；With base
The tangent line of plinth figure-eight coil is symmetry axis, and the coil of lower floor occurs in pairs；The distance of each layer coil central axe and symmetry axis below
The optimization method of solution is：
Object function：min E(z0)/E(z)
Constraints：lb(r2,r3,...,rn)≤(r2,r3,...,rn)≤ub(r2,r3,...,rn)
In formula, it is induction field on figure-eight coil center line z0 at away from orlop coil depth that E (z0), which is, E (z) for away from
Orlop coil depth is the induction field on the figure-eight coil center line at z, and E (z0)/E (z) is the ratio of the two, optimization
Target be to make E (z0)/E (z) minimum；Optimized variable is (r2,r3…,rn), r2,r3…,rnFor inner coil 2, coil 3 ...,
Coil n center line is to the distance of 8-shaped center line, lb (r2,r3…,rn) and ub (r2,r3…,rn) be respectively downstream condition and
Upper boundary conditions, meet that deep position Neural stem cell E (z0)/E (z) tries one's best small requirement.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510398375.2A CN105597234B (en) | 2015-07-09 | 2015-07-09 | Multilayer bias figure-eight coil for deep position transcranial magnetic stimulation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510398375.2A CN105597234B (en) | 2015-07-09 | 2015-07-09 | Multilayer bias figure-eight coil for deep position transcranial magnetic stimulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105597234A CN105597234A (en) | 2016-05-25 |
| CN105597234B true CN105597234B (en) | 2018-03-30 |
Family
ID=55977925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510398375.2A Active CN105597234B (en) | 2015-07-09 | 2015-07-09 | Multilayer bias figure-eight coil for deep position transcranial magnetic stimulation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105597234B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109260595B (en) * | 2018-11-08 | 2023-09-12 | 深圳英智科技有限公司 | Transcranial magnetic stimulation coil and manufacturing method thereof |
| CN109745621A (en) * | 2019-02-18 | 2019-05-14 | 天津大学 | A kind of volume body coils tangent for more circles of deep transcranial magnetic stimulation |
| US20210330987A1 (en) * | 2019-05-09 | 2021-10-28 | Wuhan Znion Technology Co., Ltd | Integrated tms coil for brain testing and treatment |
| CN113559417B (en) * | 2021-07-23 | 2022-02-01 | 杭州米福科技有限公司 | Transcranial magnetic stimulation coil for deep accurate magnetic stimulation and helmet |
| CN113440731B (en) * | 2021-08-11 | 2022-02-15 | 成都理工大学 | Asymmetric special-shaped coil for craniocerebral electromagnetic stimulation and craniocerebral electromagnetic stimulation system |
| CN115887932B (en) * | 2022-11-09 | 2023-08-29 | 成都理工大学 | Tangential surrounding type space array and system for deep craniocerebral noninvasive focusing stimulation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1224367A (en) * | 1996-04-26 | 1999-07-28 | 乌尔姆大学生物医学工程研究中心 | Method and apparatus for focused neuromagnetic stimulation and detection |
| US8523753B2 (en) * | 2007-11-27 | 2013-09-03 | Cervel Neurotech, Inc. | Transcranial magnet stimulation of deep brain targets |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5896109B2 (en) * | 2010-11-25 | 2016-03-30 | 国立大学法人大阪大学 | Magnetic coil unit for treatment |
-
2015
- 2015-07-09 CN CN201510398375.2A patent/CN105597234B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1224367A (en) * | 1996-04-26 | 1999-07-28 | 乌尔姆大学生物医学工程研究中心 | Method and apparatus for focused neuromagnetic stimulation and detection |
| US8523753B2 (en) * | 2007-11-27 | 2013-09-03 | Cervel Neurotech, Inc. | Transcranial magnet stimulation of deep brain targets |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105597234A (en) | 2016-05-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105597234B (en) | Multilayer bias figure-eight coil for deep position transcranial magnetic stimulation | |
| US11491343B2 (en) | Coil apparatus for use in transcranial magnetic stimulation apparatus provided with wound-wire coil disposed on or near head surface | |
| Wagner et al. | Biophysical foundations underlying TMS: setting the stage for an effective use of neurostimulation in the cognitive neurosciences | |
| KR102121673B1 (en) | Coil and magnetic stimulator using same | |
| US10086201B2 (en) | Electronic stimulation device, method of treatment and electronic stimulation system | |
| US8718778B2 (en) | Apparatus and method for neurocranial electrostimulation | |
| Moreno-Duarte et al. | Transcranial electrical stimulation: Transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), transcranial pulsed current stimulation (tPCS), and transcranial random noise stimulation (tRNS) | |
| EP3449974B1 (en) | Device for magnetic stimulation for the treatment of neurological disorders | |
| EP2183025B1 (en) | Firing patterns for deep brain transcranial magnetic stimulation | |
| Treister et al. | Non-invasive transcranial magnetic stimulation (TMS) of the motor cortex for neuropathic pain—at the tipping point? | |
| US10518098B2 (en) | Methods and systems for controlling magnetic fields and magnetic field induced current | |
| Wongsarnpigoon et al. | Computer-based model of epidural motor cortex stimulation: effects of electrode position and geometry on activation of cortical neurons | |
| US9770592B2 (en) | Electronic stimulation system and device thereof for dorsal root ganglion | |
| Hsu et al. | Analysis of efficiency of magnetic stimulation | |
| EP2958621B1 (en) | Circular coils for deep transcranial magnetic stimulation | |
| WO2016057855A1 (en) | Methods and apparatus for stimulation of biological tissue | |
| Kesikburun | Non-invasive brain stimulation in rehabilitation | |
| EP2810690A1 (en) | A system for planning and/or providing a therapy for neural applications | |
| Sorkhabi et al. | Temporally interfering TMS: focal and dynamic stimulation location | |
| CN114796875B (en) | Electromagnetic stimulation method, device, equipment and readable storage medium | |
| Gomez-Tames et al. | A simulation study on the dominance of the Tissues' conductivity in the muscle recruitment | |
| Guadagnin et al. | Modelling of deep transcranial magnetic stimulation: different coil configurations | |
| CN109745621A (en) | A kind of volume body coils tangent for more circles of deep transcranial magnetic stimulation | |
| Barker et al. | Transcranial magnetic stimulation | |
| US20220040491A1 (en) | Methods and Systems for Non-Invasive Focalized Deep Brain Stimulation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |