CN105596036B - A kind of plug-type steril cell brush of scope of replaceable brush head - Google Patents
A kind of plug-type steril cell brush of scope of replaceable brush head Download PDFInfo
- Publication number
- CN105596036B CN105596036B CN201610062426.9A CN201610062426A CN105596036B CN 105596036 B CN105596036 B CN 105596036B CN 201610062426 A CN201610062426 A CN 201610062426A CN 105596036 B CN105596036 B CN 105596036B
- Authority
- CN
- China
- Prior art keywords
- brush head
- cytobrush
- brush
- guiding tube
- head
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/04—Endoscopic instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B2010/0216—Sampling brushes
Abstract
The invention discloses a kind of plug-type steril cell brushes of scope of replaceable brush head; including guiding tube, brush head, load push-pull and traction fiber; brush head is detachably connected to the head of guiding tube; cytobrush is equipped in brush head, the one end of brush head far from guiding tube is equipped with opening, and traction fiber penetrates in guiding tube; one end and cytobrush detachable connection; the other end is connected with load push-pull, and cytobrush is externally provided with protective film, and protective film head is connect with brush head, tail portion and cytobrush tail portion connect.Built-in cytobrush can be under the cooperation of guiding tube and load push-pull in live body enteric cavity wall swipe intestinal mucosa surface layer bacterium biopsy sample and/or cell sample in the present invention; meanwhile bacterium caused by the pollution of colonoscopy biopsy forceps channel/cytobrush pollution can also be avoided under the protection of protective film.Also replaceable sterile brush head after use so that cytobrush can keep the reuse under germ-free condition, save the confidence level of each position sample collection of enteron aisle while cost-effective to the greatest extent.
Description
Technical field
The invention belongs to cell/bacterial sampling engineering device technique fields, and in particular to a kind of scope of replaceable brush head is with pushing away
Pull-type steril cell brush.
Background technology
It is known that under scope living tissue, cell acquisition, be one of the means and methods of common clinical diagnosis.For swollen
The disease of the types such as tumor, inflammation has important diagnostic value.Although clinically conventional obtain group using disposable cytobrush
It knits, but still there is the sample because caused by polluting biopsy forceps channel and interfere.
In addition, intestinal microecology system is the important foundation of human health and disease, in physiology, pathology, prevent, treat
All play an important role.The trophism of enteric microorganism is extremely important, such as synthesizes vitamin, digest carbohydrate, ammonia
Utilization, fat utilization and the certain enzymes of synthesis.Intestinal microecology system can make a change according to the characteristics of food, with its work(
Can diversity and larger adaptability cope with the variation of external environment.To seek the nutrition of enteric microorganism and body and being good for
The correlation and its machining function of health, aging or disease, more and more researchers are begun to focus on to enteric microorganism
Research.
Currently, generally by enteric microorganism situation is obtained to excreta sampling, but the microorganism in excreta with
Inevitable different under condition of living organism, only directly acquiring the enteric microorganism of condition of living organism can enable data more smart
Really, it is still short of the dedicated unit for sampling enteric microorganism from human body live body and germ-free condition capable of being kept at present.
Invention content
To solve the above problems, the invention discloses a kind of cytobrush for sampling condition of living organism lower intestinal tract microorganism,
Interchangeable brush head is devised, can be reused, and germ-free condition can be kept.
In order to achieve the above object, the present invention provides the following technical solutions：
A kind of plug-type steril cell brush of replaceable brush head, including guiding tube, brush head, load push-pull and traction fiber, it is described
Brush head is detachably connected to the head of guiding tube, cytobrush is equipped in brush head, and the one end of brush head far from guiding tube is equipped with opening,
The traction fiber penetrates in guiding tube, and one end and cytobrush detachable connection, the other end are connected with load push-pull, the cell
Brush is externally provided with protective film, and the protective film head is connect with brush head, tail portion and cytobrush tail portion connect.
Further, the protective film head is connect with brush head open edge.
Further, the opening is equipped with sealer, and a part for sealer is connect with brush head and sealer can cover opening.
Further, the brush head is connect by clamping structure or helical structure with guiding tube.
Further, the cytobrush tail portion is connect by clamping structure or helical structure with traction fiber.
Further, also there is position limiting structure, the position limiting structure can prevent cytobrush from entering in guiding tube.
Further, the guiding tube can generate deformation.
Further, the protective film is made of silica gel.
Further, the traction fiber is steel wire.
Compared with prior art, the invention has the advantages that and advantageous effect：
Built-in cytobrush can be under the cooperation of guiding tube and load push-pull in live body enteric cavity wall swipe enteron aisle in the present invention
Mucosal surface cell and/or bacterium biopsy sample, meanwhile, colonoscopy biopsy forceps channel can also be avoided dirty under the protection of protective film
Cytobrush pollution caused by dye.The present invention replaceable sterile brush head after use so that cytobrush can be kept under germ-free condition
Reuse, the confidence level of each position sample collection of enteron aisle is saved while cost-effective to the greatest extent.
Description of the drawings
Fig. 1 is the plug-type steril cell brush overall structure signal in the initial state of replaceable brush head provided by the invention
Figure；
Fig. 2 is that cell brush element stretches out status diagram in plug-type steril cell brush；
Fig. 3 be plug-type steril cell brush in cytobrush stretch out status diagram, wherein protective film because be extruded almost at
It is flat to be not drawn into figure；
Fig. 4 is brush-head structure schematic diagram；
Fig. 5 is brush head left view；
Fig. 6 is brush head right view；
Fig. 7 is the brush head and guiding tube coupling part sectional view using clamping structure；
Fig. 8 is the brush head and guiding tube coupling part sectional view using helical structure.
Reference numerals list：
1- guiding tubes, 2- brush heads, 3- load push-pulls, 4- traction fibers, 5- cytobrush, 6- protective films, 7- openings, 8- sealers, 9-
Limited block, 10- connectors, 11- draw mouth, 12- projections, 201- brush head clamping joints, 101- brush head card holes, the clamping of 501- cytobrush
Head, correspondingly, 401- cytobrush card holes, 202- brush head screw rods, 102- brush head screw holes, 502- cytobrush screw rods, 402- cytobrush
Screw hole.
Specific implementation mode
Technical solution provided by the invention is described in detail below with reference to specific embodiment, it should be understood that following specific
Embodiment is only illustrative of the invention and is not intended to limit the scope of the invention.It should be noted that middle use is described below
Word "front", "rear", "left", "right", "up" and "down" refer to the direction in attached drawing, what word "inner" and "outside" respectively referred to
Be directed towards or far from geometric center of specific component direction.
Such as a kind of Fig. 1~plug-type steril cell brush of replaceable brush head shown in Fig. 7, including guiding tube 1, brush head 2, push away
It is in elongated cylindrical to draw device 3 and traction fiber 4, guiding tube 1, and for length up to 1-2 meters, brush head 2 is the class that class is cylindrical or head is slightly smaller
Cylinder, diameter 2.7mm, length 3cm, brush head 2 are connected to the head of guiding tube 1, aforenoted remov knot by detachable structure
The realizations such as conventional clamping structure or helical structure can be used in structure.Cytobrush 5,2 head of brush head are equipped in brush head 2（With left in scheming
Side is head, similarly hereinafter）With opening 7, so that cytobrush 5 comes in and goes out.Load push-pull 3 is located at the tail portion of traction fiber 4（It is with right in scheming
Tail portion, similarly hereinafter）, traction fiber 4 is in guiding tube 1, and head is connect with cytobrush 5, tail portion is connected with load push-pull 3.In brush head
It is additionally provided with protective film 6, which is covered in outside cytobrush 5, and 6 head of protective film is connect with 2 inner wall of brush head, and tail portion connects
Then the tail portion of cytobrush 5,5 length of cytobrush about 2cm are cladded with protective film maximum diameter about 2.7mm.Cytobrush 5 and traction
Silk 4 is directly connected using detachable structure, likewise, it is removable to realize that the conventional structures such as clamping structure or helical structure can be used
Unload ground effect.Preferably, cytobrush 5 and the connection structure of traction fiber 4 should be consistent with the connection structure of brush head 2 and guiding tube 1, just
In installation.Since live body enteron aisle knee is more, guiding tube 1, which should use oppress with external environment, generates bending and shape
The material of change is made, and push-and-pull steel wire can be used in traction fiber 4.It should be noted that plug-type steril cell brush is only in diagram
Schematic diagram, cytobrush 5 in figure, brush head 2, guiding tube 1, load push-pull 3, traction fiber 4 proportionate relationship not as the present invention limitation.
Fig. 7, Fig. 8 are the sectional view of 1 coupling part of brush head 2 and guiding tube.Specifically, Fig. 7 is interface arrangment schematic diagram,
Wherein, 2 bottom of brush head has brush head clamping joint 201 outstanding, correspondingly, having and brush head card interface phase on 1 head of guiding tube
The brush head card hole 101 of adaptation；There is cytobrush clamping joint 501 outstanding in the tail portion of cytobrush 5, correspondingly, in traction fiber 4
Portion has cytobrush card hole compatible with cytobrush clamping joint 501 401.When connection brush head 2 and guiding tube 1, preferably first connect
Cytobrush clamping structure is connect, cytobrush clamping joint 501 is stretched into fixed in cytobrush card hole 401（Due to traction fiber and guiding tube
Connection relation is had no, therefore traction fiber head can be extracted to a part and be attached cytobrush connection）, subsequent connection brush head clamping
Brush head clamping joint 201 is stretched into brush head card hole 101 and fixed by structure, that is, completes the connection of brush head and guiding tube.Fig. 8 is another kind
Relatively conventional helical structure schematic diagram, wherein brush head bottom has brush head screw rod 202 outstanding, correspondingly, in guiding tube 1
Head has brush head screw hole compatible with brush head card interface 102；There is cytobrush screw rod outstanding in the tail portion of cytobrush 5
502, correspondingly, there is cytobrush screw hole compatible with cytobrush screw rod 502 402 on 4 head of traction fiber.Connect under this structure
When connecing brush head with guiding tube, while cytobrush helical structure is connected, cytobrush screw rod 502 is directed at cytobrush screw hole 402, brush head
Screw rod 202 is directed at brush head screw hole 102, subsequent rotational head and/or guiding tube, that is, completes the connection of brush head 2 and guiding tube 1.
As shown in Figure 1, protective film 6 substantially olive shape or elliposoidal, head has the opening that can hold the stretching of cytobrush 5,
The opening is preferably in closed state when being not subject to external force, and 6 head of protective film can be directly or by connector 10（Connector can
It is made of rigidity or flexible material, preferably silica gel）It is connect with the 7 edge inner walls of opening of brush head 2, the tail portion of protective film 6 is connected to
On 5 tail portion brush handle of cytobrush.Protective film 6 is preferably made of silica gel, has good ductility and elasticity.As needed, it protects
Film 6 can also use other shapes.
Further, although protective film 6 can form good protection to cytobrush 5, since 2 head of brush head is equipped with opening
7 still may cause the pollution of cytobrush 5, therefore be additionally provided with sealer 8 at opening 7, and a part for the sealer 8 is connect with brush head
And sealer can cover opening 7 when being not subject to external force.Sealer 8 is preferably outward opening, has stronger preventing polluting effect.
Preferably, handle shape of the load push-pull for ease of grasping, easy to operate.
Further, the present invention is also provided with position limiting structure in the device, which can prevent the cytobrush quilt in brush head
It excessively pulls back in guiding tube, as shown in fig. 6,2 tail portion of brush head has the traction mouth 11 stretched into for traction fiber, traction mouth diameter big
In or equal to traction fiber outer diameter.And it is circle that cytobrush tail portion, which has limited block 9, limited block 9, diameter is more than traction mouth diameter,
When traction fiber drives cytobrush to pull back, limited block 9 can guarantee cytobrush trailer card at traction mouth without bouncing back to guiding
Guan Zhong, when 9 diameter of limited block be more than brush head be open 7 diameter when, limited block 9 can also limit cytobrush will not stretch out it is long.This
Outside, the sealer that can be opened when by external force can be equipped with by drawing at mouth, can further avoid the cytobrush after sampling to leading
Draw the pollution of silk.Certainly, other, which also can be used, can limit other conventional position limiting structures that cytobrush 5 enters guiding tube 1.
Cytobrush and brush head are preferably able to be separated from each other, and cytobrush can be fixed on by limited block 9 on brush head, as Fig. 7,
Shown in Fig. 8, there is the projection 12 extended to brush head head on brush head tail end inner wall, has on limited block corresponding with projection logical
Projection 12, is caught in the fixation that brush head and cytobrush can be realized in through-hole by hole, the pico- bulging in projection head enable projection not by
It is not easy to skid off from through-hole when to external force.
Using this plug-type steril cell brush when, guiding tube head install brush head, by brush head cytobrush and lead
Draw silk to link together by cytobrush clamping structure or helical structure, and brush head is connected with guiding tube by brush head clamping structure
It is connected together.Then, brush head and entire guiding tube are stretched into endoscopic forceps channel, advances and recycled in biopsy forceps channel
Cheng Zhong, the cytobrush in brush head avoid polluting under the protection of protective film, keep germ-free condition.After reaching sampled point, push
Load push-pull, by traction fiber by cytobrush self-insurance cuticula and brush head opening ejection, since one end of protective film is connected on brush head,
Therefore it is opened naturally under the traveling of cytobrush, then affects bacterium brush swipe enteric cavity parietal cell/bacterium live body using load push-pull
Sample is sampled.After swipe, load push-pull of pulling back withdraws cytobrush in brush head, and extracts guiding tube 1 out while taking brush out of
Head completes sampling.After sampling, brush head is unloaded, the microorganism in cytobrush is tested, guiding tube is cleaned, in next time
Clean brush head and cytobrush therein are replaced when sampling.
The technical means disclosed in the embodiments of the present invention is not limited only to the technological means disclosed in the above embodiment, further includes
By the above technical characteristic arbitrarily the formed technical solution of combination.It should be pointed out that for those skilled in the art
For, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also considered as
Protection scope of the present invention.
Claims (9)
1. a kind of plug-type steril cell brush of replaceable brush head, it is characterised in that：Including guiding tube（1）, brush head（2）, push-and-pull
Device（3）And traction fiber（4）, the brush head（2）It is detachably connected to guiding tube（1）Head, cytobrush is equipped in brush head
（5）, brush head（2）Far from guiding tube（1）One end be equipped with opening（7）, the traction fiber（4）Penetrate guiding tube（1）It is interior, one end
With cytobrush detachable connection, the other end and load push-pull（3）It is connected, the cytobrush（5）It is externally provided with protective film（6）, described
Protective film（6）Head and brush head（2）Connection, tail portion and cytobrush（5）Tail portion connects.
2. the plug-type steril cell brush of replaceable brush head according to claim 1, it is characterised in that：The protective film
（6）Head and brush head（2）Open edge connects.
3. the plug-type steril cell brush of replaceable brush head according to claim 1 or 2, it is characterised in that：The opening
（7）Place is equipped with sealer（8）, sealer（8）A part and brush head（2）It connects and sealer can cover opening（7）.
4. the plug-type steril cell brush of replaceable brush head according to claim 1, it is characterised in that：The brush head（2）
Pass through clamping structure or helical structure and guiding tube（1）Connection.
5. the plug-type steril cell brush of replaceable brush head according to claim 1 or 4, it is characterised in that：The cell
Brush（5）Tail portion passes through clamping structure or helical structure and traction fiber（4）Connection.
6. the plug-type steril cell brush of replaceable brush head according to claim 1 or 2, it is characterised in that：Also there is limit
Bit architecture（9）, the position limiting structure can prevent cytobrush（5）Into guiding tube（1）It is interior.
7. the plug-type steril cell brush of replaceable brush head according to claim 1 or 2, it is characterised in that：The guiding
Pipe（1）Deformation can be generated.
8. the plug-type steril cell brush of replaceable brush head according to claim 1 or 2, it is characterised in that：The protection
Film（6）It is made of silica gel.
9. the plug-type steril cell brush of replaceable brush head according to claim 1 or 2, it is characterised in that：The traction
Silk（4）For steel wire.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610062426.9A CN105596036B (en) | 2016-01-29 | 2016-01-29 | A kind of plug-type steril cell brush of scope of replaceable brush head |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610062426.9A CN105596036B (en) | 2016-01-29 | 2016-01-29 | A kind of plug-type steril cell brush of scope of replaceable brush head |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105596036A CN105596036A (en) | 2016-05-25 |
| CN105596036B true CN105596036B (en) | 2018-07-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610062426.9A Active CN105596036B (en) | 2016-01-29 | 2016-01-29 | A kind of plug-type steril cell brush of scope of replaceable brush head |
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| CN (1) | CN105596036B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106344078A (en) * | 2016-08-29 | 2017-01-25 | 孟红琳 | Continuous-sampling device on ribbon gastroscope biopsy |
| CN108577896A (en) * | 2018-03-20 | 2018-09-28 | 四川大学华西第二医院 | Specimen collecting bottle |
| CN109893260A (en) * | 2019-03-06 | 2019-06-18 | 武汉大学 | A kind of soft scope pipeline brushing device |
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|---|---|---|---|---|
| US4227537A (en) * | 1978-03-08 | 1980-10-14 | Tucson Medical Instruments, Inc. | Endometrial brush with slidable protective sleeve |
| JPH08280693A (en) * | 1995-04-17 | 1996-10-29 | Olympus Optical Co Ltd | Biopsy brush jig for endoscope |
| CN203000998U (en) * | 2012-09-13 | 2013-06-19 | 牛青山 | A silicone rubber oral cavity swab |
| CN203525105U (en) * | 2013-09-26 | 2014-04-09 | 中国人民解放军沈阳军区总医院 | Protective hairbrush with cleaning function, provided with scales and matched with trachea cannula |
| CN203802499U (en) * | 2014-04-01 | 2014-09-03 | 冯靖 | Contamination prevention cell brush |
| US9095330B2 (en) * | 2013-03-13 | 2015-08-04 | Cook Medical Technologies Llc | Perforated tube for cell collection |
| CN205379317U (en) * | 2016-01-29 | 2016-07-13 | 孙昊 | Scope of displaceable brush head is with plug -type aseptic cytobrush |
-
2016
- 2016-01-29 CN CN201610062426.9A patent/CN105596036B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4227537A (en) * | 1978-03-08 | 1980-10-14 | Tucson Medical Instruments, Inc. | Endometrial brush with slidable protective sleeve |
| JPH08280693A (en) * | 1995-04-17 | 1996-10-29 | Olympus Optical Co Ltd | Biopsy brush jig for endoscope |
| CN203000998U (en) * | 2012-09-13 | 2013-06-19 | 牛青山 | A silicone rubber oral cavity swab |
| US9095330B2 (en) * | 2013-03-13 | 2015-08-04 | Cook Medical Technologies Llc | Perforated tube for cell collection |
| CN203525105U (en) * | 2013-09-26 | 2014-04-09 | 中国人民解放军沈阳军区总医院 | Protective hairbrush with cleaning function, provided with scales and matched with trachea cannula |
| CN203802499U (en) * | 2014-04-01 | 2014-09-03 | 冯靖 | Contamination prevention cell brush |
| CN205379317U (en) * | 2016-01-29 | 2016-07-13 | 孙昊 | Scope of displaceable brush head is with plug -type aseptic cytobrush |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105596036A (en) | 2016-05-25 |
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Inventor after: Sun Hao Inventor after: Sun Guoqing Inventor after: Wu Xudong Inventor after: Zhang Jinsong Inventor before: Sun Guoqing Inventor before: Sun Hao Inventor before: Wu Xudong Inventor before: Chen Zhitan Inventor before: Zhang Jinsong |
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Effective date of registration: 20181015 Address after: 210029 Guangzhou Road, Gulou District, Nanjing, Jiangsu 300 Co-patentee after: Sun Guoqing Patentee after: Jiangsu Province People's Hospital (the First Affiliated Hospital of Nanjing Medical University) Address before: 210029 Guangzhou Road, Gulou District, Nanjing, Jiangsu 300 Patentee before: Sun Hao |
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