CN105595975A

CN105595975A - Differential closed-loop sampling circuit, pulse diagnosis instrument and traditional Chinese medicine pulse diagnosis system health service platform

Info

Publication number: CN105595975A
Application number: CN201610149987.2A
Authority: CN
Inventors: 刘苏; 张劭龙; 耿兴光; 张以涛; 张俊; 侯洁娜; 张海英
Original assignee: Institute of Microelectronics of CAS
Current assignee: Institute of Microelectronics of CAS
Priority date: 2016-03-16
Filing date: 2016-03-16
Publication date: 2016-05-25

Abstract

A differential closed-loop sampling circuit comprises pulse diagnosis array sensors for acquiring pulse signals of an examinee and a signal processing unit for conducting digital processing on the pulse signals acquired by the pulse diagnosis array sensors, wherein the positions of the pulse diagnosis array sensors are designed according to the gold standards of upper cun, cun, guan, chi and lower chi diagnosis. The invention further provides a pulse diagnosis instrument and a traditional Chinese medicine pulse diagnosis system health service platform. The health service platform comprises a cloud storage and cloud processing platform for conducting cloud storage on detection results and performing later-period disease matching and treatment scheme selection through cloud computing. The pulse data of patients is more objectively and accurately through the differential closed-loop sampling circuit, schemes are implemented through internet of things to obtain optimized configuration of traditional Chinese medicine resources, and the cognition degree of the public to the traditional Chinese medicine is improved. 25 point arrays are established according to upper cun, cun, guan, chi and lower chi, and an array arrangement spacing for achieving better diagnosis and treatment effects is obtained through experiments.

Description

Difference closed loop sample circuit, pulse-taking instrument and Chinese medicine pulse-taking system health service platform

Technical field

The present invention relates to Chinese traditional medical diagnose equipment technical field, relate more specifically to a kind of difference closed loop samplingCircuit, pulse-taking instrument and Chinese medicine pulse-taking system health service platform, particularly about the circuit of diagnosis by feeling the pulse diagnosis and treatmentSystem and Internet of Things application scheme.

Background technology

PVDF sensor has been widely used in modern Chinese medicine diagnostic equipment, and this sensor relies on certainlyStature material and parameter advantage by people extracting in the application of characteristics of human body parameter as preferred version.But follow more and more harsher applied environment, some problems that PVDF sensor application produces also withCome out.

The characteristic that the above PVDF sensor of 10mm is good at present, a large amount of polarization charge, relatively steadyDetermining parameter attribute and shielding construction makes follow-up signal modulate circuit not consider charge share, electricityLotus is dissipated, and noise jamming, under the condition of the individual parameter differences of sensor, realizes the base that pulse wave detectsThis function. But along with further dwindling of flexible material, the capacitance parameter of itself also can diminish,The amount of polarizing charge producing also can correspondingly reduce, and this just makes charge share and charge dissipation phenomenon become the utmost pointFor obviously, make to utilize conventional input impedance amplifier and this General Signal Conditioning of analog switch withoutMethod obtains useful signal; Secondly, PVDF size sensor further reduce the sensing that also can bringThe poor problem of the individual parameter consistency of device, therefore, with the small size PVDF sensing of array format compositionDevice group cannot be measured a certain position and the almost identical signal in neighborhood position around thereof. Again, PVDFSensor cannot shield under small size, and the noise jamming of introducing is very big. At present, there is no a kind of letterNumber modulate circuit solution is for above-mentioned situation.

In addition, existing traditional Chinese medical science pulse wave detects and control circuit system is pressurizeed and 3 points with Wrist belt-type substantiallyThe signal controlling treatment system that machinery pressure structure is background, its Circuits System function is relatively single. Not yetHave a kind of based on small-sized PVDF sensor array pulse wave acquisition process and support complex mechanical structure thereofThe Circuits System of peripheral hardware.

Summary of the invention

For above-mentioned technical problem, the object of the present invention is to provide a kind of difference closed loop sample circuit,Pulse-taking instrument and Chinese medicine pulse-taking system health service platform, mainly solve pulse wave spectrum diagnosis and treatment validity problem,Be initial point from the diagnosis by feeling the pulse goldstandard of grasping, make the traditional Chinese medical science by accurate frame for movement and circuit acquisition systemDiagnosis by feeling the pulse treatment standardization, promotes diagnosis and treatment validity, reduces doctor of traditional Chinese medicine because the fatigue that works long hours is madeThe Error Diagnostics becoming, for not having the place of medical condition that effective Chinese traditional medical diagnose supporting is provided, pushes awayMoving traditional Chinese medical science development.

For achieving the above object, as one aspect of the present invention, the invention provides a kind of difference and closeRing sample circuit, comprising:

Diagnosis by feeling the pulse sensor array, for collecting test person's pulse signal, and according to very little upper, very little, close,Under chi, chi, diagnose goldstandard design sensor array column position; And

Signal processing unit, for carrying out numeral to the pulse signal of described diagnosis by feeling the pulse sensor array collectionProcess.

Wherein, described diagnosis by feeling the pulse sensor array adopts the flexible material of 25 of the five-element's five row of 5 × 5 to pressPower sensor construction, the flexible material pressure of or 3 × 83 row 8 row 24 points+discrete 1 passesSensor structure, the flexible material pressure sensor of wherein said discrete 1 picks out by flexible wire,Can need to adjust detection position according to operator.

Wherein, the sensor points line space of described diagnosis by feeling the pulse sensor array is sensor points column pitch1.5 times to 3 times.

Wherein, described signal processing unit comprises preposition differential charge amplifying circuit, 4 rank ButterworthsThe ADC/DAC circuit of low pass filter, closed loop feedback system and the output of support generating positive and negative voltage; And

Described signal processing unit has preferably adopted bussing technique.

Wherein, the sample frequency of described ADC/DAC circuit all between 100-1000KHz scope,The pulse signal that described pulse wave spectrum sensor device is detected is realized over-sampling.

Wherein, described preposition differential charge amplifying circuit comprise high input impedance the first operational amplifier,The second operational amplifier, and the first output operational amplifier of zero shift, low noise rail-to-rail; ItsIn one end, of the inverting input of the first operational amplifier and 1 end of the first plug, the first electric capacityOne end of one resistance is connected, the other end, first of the output of the first operational amplifier and the first electric capacityThe other end of resistance is connected, one end of the in-phase input end of the first operational amplifier and the 6th resistance, theThe in-phase input end of two operational amplifiers is connected, and the other end of the 6th resistance is connected with GND; Second1 end of the inverting input of operational amplifier and the second plug, one end, the 19 of the 12 electric capacityOne end of resistance is connected, the output of the second operational amplifier and the other end of the 12 electric capacity, the tenthThe other end of nine resistance, one end of the 15 resistance is connected, and 2 ends of the second plug are connected with GND;The inverting input of the first output operational amplifier and one end of the second resistance, one end phase of the 5th resistanceConnect, the output of the first output operational amplifier is connected with the other end of the second resistance, the first output fortuneCalculate the in-phase input end of amplifier and the other end of the 15 resistance, one end of the 18 resistance and be connected,The other end of the 18 resistance is connected with GND; 4 ends of the first operational amplifier and-5V, the second electricityHold one end and be connected, the other end of the second electric capacity is connected with GND; 8 ends of the first operational amplifier with+ 5V, the 6th electric capacity one end are connected, and the other end of the 6th electric capacity is connected with GND; The first output fortune11 ends of calculating amplifier are connected with-5V, the 3rd electric capacity one end, the other end of the 3rd electric capacity and GNDBe connected; 4 ends of the first output operational amplifier are connected with+5V, the 8th electric capacity one end, the 8th electric capacityThe other end be connected with GND;

Described 4 rank Butterworth LPF preferably include second of zero shift, low noise rail-to-railOutput operational amplifier and the 3rd output operational amplifier; The homophase input of the second output operational amplifierEnd is connected with one end of the 8th resistance, one end of the 4th electric capacity, the 4th electric capacity other end and GND phaseConnect the reverse input end of the second output operational amplifier and one end of the 12 resistance, the 16 resistanceOne end be connected, the other end of the 16 resistance is connected with GND; The second output operational amplifierOutput is connected with the other end of the 12 resistance, the other end of the tenth electric capacity; The 9th resistance one end withThe second output operational amplifier is connected, one end, the 11 of the other end of the 9th resistance and the tenth resistanceOne end of electric capacity is connected; The other end of the in-phase input end of the 3rd output operational amplifier and the tenth resistance,One end of the 5th electric capacity is connected, and the 5th electric capacity other end is connected with GND; The 3rd output operation amplifierThe reverse input end of device is connected with one end of the 13 resistance, one end of the 17 resistance, the 17 electricityThe other end of resistance is connected with GND; The output of the 3rd output operational amplifier and the 13 resistanceThe other end of the other end, the 11 electric capacity is connected; Wherein the 8th resistance, the 12 resistance, the 16Resistance, the 4th electric capacity, the tenth electric capacity and the 9th resistance, the tenth resistance, the 13 resistance, the 17Resistance, the 5th electric capacity, two second-order low-pass filters of the 11 electric capacity composition, by changing the 12Resistance, the 16 resistance, the 13 resistance, the 17 resistance composition quadravalence Butterworth LPFDevice.

Wherein, described signal processing unit comprises preposition differential charge amplifying circuit, 4 rank ButterworthsLow pass filter, 16 adc circuits of the parallel input in 8 tunnels, micro-processing and control element (PCE), 8 roads walk abreastInput 16 digital-to-analogue conversion current potential benchmark Circuit tunings, No. 8 followers and 8 tunnel adders; And

Described signal processing unit is carried out following datum error correcting process:

One of the diagnosis by feeling the pulse sensor array of given described pulse wave spectrum sensor device in sometimeForce value, force value is entered by preposition differential charge amplifying circuit, 4 rank Butterworth LPFEnter 16 adc circuits of the parallel input in 8 tunnels, this force value is converted into digital quantity and enters micro-processing controlUnit, micro-processing and control element (PCE) is sent the information of processing into 16 digital-to-analogue conversions of the parallel input in 8 tunnelsCurrent potential benchmark Circuit tuning, the data signal of processing be converted into analog signal by No. 8 followers withPrimary signal is added correction in 8 tunnel adders, and 8 tunnel adders are further sent correction value into 8 tunnels16 adc circuits of parallel input, this circulation process makes each sensor in described diagnosis by feeling the pulse sensor arrayMagnitude of voltage reach unanimity.

As another aspect of the present invention, the present invention also provides a kind of pulse-taking instrument, described pulse-taking instrumentComprise difference closed loop sample circuit as above.

Wherein, described pulse-taking instrument is domestic portable pulse-taking instrument or doctor's pulse-feeling instrument.

As another aspect of the present invention, the present invention also provides a kind of Traditional Chinese medicinal wrist precious system health clothesBusiness platform, comprising:

Pulse-taking instrument as above; And

Cloud storage and cloud processing platform, for the detection knot to described pulse-taking instrument/pulse wave spectrum diagnosis and therapy systemFruit carries out cloud storage, and utilizes cloud computing to carry out choosing of later stage illness coupling and therapeutic scheme.

Difference closed loop sample circuit of the present invention, diagnosis and therapy apparatus and health service platform have the following advantages:

(1) the present invention is first by large-scale diagnosis and treatment frame for movement, difference closed loop sampling system and Internet of ThingsEmbodiment three combines, and builds pulse wave spectrum diagnosis and therapy system health service platform; This platform passes throughMachine Design ensures stability and the repeatability that patient's pulse extracts, by difference closed loop sampling system moreObjective and accurate collection patient pulse data, obtains traditional Chinese medical science resource by Internet of Things embodiment excellentChange configuration, promote the popular cognition degree to traditional Chinese medical science medical science;

(2) in the present invention, pulse wave sensor is measured structure and has been abandoned traditional fixing based on Wrist belt-typeMeasure structure with the blocking type of inflating pressure, make sensor not depend on wrist surface, but be fixed onExternal support structure, the non-blocking type structure that its pressuring method utilizes motor longitudinally to advance; This structure oneFixing and the pressure method that aspect has avoided tradition to be attached to wrist brings extra feeling of stress to patientBe subject to, also avoided the physical sign parameters bringing because occluding pressure is excessive to change, affect pulse wave and gather accurateReally property, and then cannot realize the thought of " modrate and heavey pressing " in the traditional Chinese medical science; This structure can be passed through on the other handTo wrist, pressurization realizes " heavy getting " in motor part, and wrist strap aerating structure can be not right under certain pressurePulse causes blocking-up, cannot realize " heavy getting ";

(3) in the present invention 25 lattice arrays (being not limited to 25 points) sensor can large-range measuringPulse wave fluctuation, provides data basis for building large scale pulse wave, is also identification " cun, guan and chi, three places at the wrist where the pulse is usually taken " automaticallyData foundation is provided;

(4) in the present invention, sensor supporting structure is used spring contact mode, has avoided due to sensingDevice is integrated on same medium, and cause pulse wave to pass through a certain point sensor and will fluctuate conduction to medium,And then the problem of interference all the sensors;

(5) the fixing mechanical grip mode that adopts of sensor in the present invention, solving PVDF can not weldProblem, and sensor pin and board pads machinery close contact is better than sensor conducting adhesive clothConnected mode;

(6) drive mechanism of the present invention has been introduced protecting human body structure, prevents from making because motor is out of controlPatient's injury in pairs;

(7) the present invention introduces Universal arm structure, and diagnosis by feeling the pulse sensor array is assemblied in to Universal arm one end,Facilitate doctor to draw use;

(8) in the present invention, introduce patient chair structure, ensureing patient's wrist basis concordant with heartUpper, promote patient's diagnosis and treatment comfort level, be suitable for long-time pulse detection collection; Making up existing goods is suffering fromPerson tests the consideration disappearance on position, and this disappearance causes sufferer can not keep same posture to enter for a long timeRow pulse collection, greatly affects repeatability and the stability of data;

(9) in the present invention, introduce the wrist support that attaches temperature adjustable thermostatic module, promote on the one handPatient's comfort level, provides stable testing environment, prevents on the other hand because environmental change causes blood vesselShrink and then cause measure error; Its metal structure is convenient to cleaning and sterilizing;

(10) in the present invention, sensor array adopts positive 25 dot structures and positive 24 points+discrete 1Dot structure, its 25 dot structure, according under cun upper, cun,guan,chi, chi, is set up 25 lattice arrays. Its5 × 5 arrangement mode effectively will be cun upper, large area covers under cun,guan,chi, chi. Positive 24Under the thought guidance of point+discrete 1 dot structure on very little, under cun,guan,chi, chi, change 3 × 8 intoArrangement mode, has increased the lateral length under cun upper, cun,guan,chi, chi, has shortened that it is longitudinally longDegree, is applicable to a certain elongated area to carry out precision collection; Its discrete 1 dot structure is free on positive 24Dot structure, for detection of this special circumstances of ectopic radial pulse;

(11) the present invention introduce change header structure can be in positive 25 dot structures and positive 24 points+discrete 1Between dot structure, switch, for meeting the different needs that detect;

(12) the present invention introduces a word line laser location, is convenient to aim at rasceta;

(13) in the present invention, introduce patient chair structure, ensureing patient's wrist basis concordant with heartUpper, promote patient's diagnosis and treatment comfort level, be suitable for long-time pulse detection;

(14) this structure can coordinate difference closed loop sampling system to carry out sensor array correction;

(15) preposition differential charge amplifying circuit is selected COMS high input impedance structure, greatly fallsLow PVDF sensor electric charge leakage problem; This circuit suppresses power frequency effectively by differential configuration to be disturbed;

(16) preposition differential charge amplifying circuit is compromised in signals collecting effect and circuit complexity,Make this circuit under the relatively simple condition of structure, realize pulse wave detection effect and be better than existing documentThe preposition charge amplifier circuit of array of report;

(17) owing to requiring pulse signal gain-smoothing in passband and stopband, therefore difference closed loop is adoptedSample circuit selects quadravalence Butterworth LPF to carry out filtering, and its quadravalence LPF can provideThe decay of 24db/ frequency multiplication, effectively suppresses noise more than 30Hz, in PCB limited space situation,Four-step filter can clearly be isolated pulse wave signal, greatly reduces the pressure of software filtering, savesSoftware resource;

(18) the closed loop feedback structure in difference closed loop sample circuit realizes PVDF multiple spot array base valueError correction. I.e. force value of given sensor array group in sometime, micro-processing control listUnit first obtains each channel sensor basic value from ADC, after calculated difference, corrected value by DAC andAdder feeds back to micro-processing and control element (PCE) by ADC, and then raising sensor array collection valueUniformity;

(19) difference closed loop sample circuit adopts eight road ADC/DAC chip collections, this ADC/DACGenerating positive and negative voltage output is supported in output, and Hoisting System is to output signal amplitude response scope;

(20) difference closed loop sample circuit substitutes variable connector with multi-channel A/D C, has eliminated by multichannelThe frequent error of crosstalking of bringing of switching of switch;

(21) filtration module in rectifying and wave-filtering and mu balanced circuit, by ADC/DAC chip power supply, is joinedExamine power supply, interface circuit power supply, and other chip power supplies separate by filtration module, reduce each power supplyBetween disturb;

(22) 8 tunnels of system of the present invention, 16 analog-to-digital conversion modules of parallel input and 8 tunnels are parallelInput 16 digital-to-analogue conversion current potential benchmark Circuit tuning modules and connect by parallel bus mode, convenientSimilar multimode expansion;

(23) sample rate of ADC hundreds of K realizes over-sampling to pulse wave signal, effectively reductionChange noise power spectrum;

(24) mechanical movement of peripheral circuit support equipment, heated at constant temperature module, holding circuit, steadyPress filtration ripple, serial communication function;

(25) Chinese medicine pulse-taking system health service platform is introduced Internet of Things scheme, makes the relevant money of the traditional Chinese medical scienceThe source configuration that is optimized.

Brief description of the drawings

Fig. 1 is the general structure block diagram of Chinese medicine pulse-taking system health service platform of the present invention;

Fig. 2 is the diagnosis and treatment machinery structural representation of Chinese medicine pulse-taking system health service platform of the present invention;

Fig. 3 A and Fig. 3 B are respectively the dot matrix of two kinds of sensor arraies of the present invention and arrange schematic diagram;

Fig. 4 is the schematic diagram of the bull conversion support structure in frame for movement of the present invention;

Fig. 5 is the schematic diagram of the diagnosis by feeling the pulse sensor array structure in frame for movement of the present invention;

Fig. 6 is the schematic diagram of the diagnosis by feeling the pulse sensor array drive mechanism in frame for movement of the present invention;

Fig. 7 is the schematic diagram of the diagnosis by feeling the pulse sensor array probe in frame for movement of the present invention;

Fig. 8 is the schematic diagram of the sensor spring bracing in frame for movement of the present invention;

Fig. 9 is the schematic diagram of the board structure of circuit in frame for movement of the present invention;

Figure 10 is the difference closed loop sampling system of Chinese medicine pulse-taking system health service platform of the present inventionCircuit block diagram;

Figure 11 be of the present invention in preposition charge amplifier, filter circuit, adder and followerCircuit block diagram;

Figure 12 is 16 analog to digital conversion circuit block diagrams of the parallel input in 8 tunnels in the present invention;

Figure 13 is 16 digital-to-analogue conversion current potential benchmark Circuit tuning block diagrams of the parallel input in 8 tunnels in the present invention;

Figure 14 be of the present invention in micro-processing and control element (PCE) circuit block diagram;

Figure 15 is middle rectifying and wave-filtering of the present invention and mu balanced circuit block diagram;

Figure 16 is the Internet of Things scheme schematic diagram of Chinese medicine pulse-taking system health service platform of the present invention.

Detailed description of the invention

For making the object, technical solutions and advantages of the present invention clearer, below in conjunction with concrete realityExecute example, and with reference to accompanying drawing, the present invention is described in further detail.

The invention discloses the healthy clothes of a kind of difference closed loop sample circuit, pulse-taking instrument and Chinese medicine pulse-taking systemBusiness platform, has further understanding for convenient to technical scheme of the present invention, below with pulse wave spectrumSystem health service platform is example, and sets forth by reference to the accompanying drawings explanation. Wherein it should be noted that,In this health service platform, comprise the parts such as aforesaid difference closed loop sample circuit and pulse-taking instrument, at this notAgain it is described separately.

As shown in Figure 1, Chinese medicine pulse-taking system diagnosis and treatment platform of the present invention comprises diagnosis and treatment frame for movement, poorDivide closed loop sampling system and Internet of Things solution. Patient lies in and in diagnosis and treatment frame for movement, accepts diagnosis by feeling the pulse and adoptCollection, data pass to the storage of Chinese medicine pulse-taking system cloud and cloud processing platform is enjoyed related service, thus this bagContain the Chinese medicine pulse-taking system health service platform of Internet of Things data analysis by hyundai electronics science, machine madeMake with Internet of Things service application scheme and combine with Traditional Chinese Medicine, by examining in Traditional Chinese Medicine diagnosis by feeling the pulse theoryDisconnected goldstandard mechanization, sequencing, datumization, standardization, reduce artificial Error Diagnostics, contributes toVarious Chinese traditional medical diagnose methods compare and optimize, and more effective service extensive patients, promotes the well-being of mankind.

As shown in Figure 2, the diagnosis and treatment frame for movement bag of Chinese medicine pulse-taking system health service platform of the present inventionDraw together patient chair, diagnosis and treatment table, Universal arm, bull conversion support structure, diagnosis by feeling the pulse sensor array transmission knotStructure (comprising motor), diagnosis by feeling the pulse sensor array probe, wrist support and heating film, and computer.Wherein patient chair and diagnosis and treatment table connect and compose the mechanical framework of diagnosis and therapy system platform.

This patient chair has angle and the elevating function of adjustment, for carrying patient body, adjust patient withAngle between diagnosis and treatment table and height. Patient can lie low in this patient chair, adjusts patient chair angle and heightDegree, makes patient's heart and wrist adjustment at grade. Patient chair can make patient relatively stable lastingThe same posture of maintenance and do not make patient's fatigue, contribute to gather for a long time patient's pulse data.

Computer is connected with treatment table, for human-computer dialogue.

Diagnosis and treatment table is connected with Universal arm, wrist support, computer, for the aforementioned each structure of support and connection.

Universal arm one end is connected with diagnosis and treatment table, and the other end is connected with bull conversion support structure one end, manyThe other end of conversion support structure is connected with diagnosis by feeling the pulse sensor array drive mechanism, for adjusting diagnosis by feeling the pulseRelative position between sensor array and patient's wrist, for pulse wave collection provides an outside fulcrum.This Universal arm has multiple degrees of freedom, can freely adjust sensing station, and has certain damping, can beWhile not moving, be fixed on current location.

As shown in Figure 4, bull conversion support structure comprise grip block, electric rotating machine, bull support,One word line laser and diagnosis by feeling the pulse sensor array probe, this bull conversion support supports respectively 25 diagnosis by feeling the pulsesSensor array or 24 points+discrete 1 diagnosis by feeling the pulse sensor array, thus can be at positive 25 dot structuresAnd switch between positive 24 points+discrete 1 dot structure, for meeting the different needs that detect.

In bull conversion support structure, grip block one end is connected with Universal arm, the other end and electric rotatingMachine is connected for connecting Universal arm and clamping electric rotating machine. Splined shaft one end is connected with electric rotating machine axle head,The other end is connected with the internal spline in the middle of bull support. The spline interlock of splined shaft and bull support is used forMake the rotation of bull support. There is step on splined shaft top, and end has screwed hole, can be by screw by bullOn the locked splined shaft of support. Bull support sandwich structure connects respectively 25 diagnosis by feeling the pulse array sensingsDevice and 24 points+discrete 1 diagnosis by feeling the pulse sensor array is also fixed with jackscrew, and this structure is used for making array to passSensor rotation, and then realize the function that conversion dissimilar sensor is popped one's head in.

As shown in Figure 5, as an example of 24 points+discrete 1 diagnosis by feeling the pulse sensor array example, this diagnosis by feeling the pulse array is describedSensor. Diagnosis by feeling the pulse sensor array structure comprise diagnosis by feeling the pulse sensor array drive mechanism, microswitch andDiagnosis by feeling the pulse sensor array probe. Diagnosis by feeling the pulse sensor array drive mechanism and the precious sensor array probe of arteries and veins phaseBe used in conjunction in making diagnosis by feeling the pulse sensor array probe do vertical movement, microswitch and diagnosis by feeling the pulse sensor array passMoving structure is connected for generation of position reset signal.

As shown in Figure 7, diagnosis by feeling the pulse sensor array probe comprise sensor contact (not shown),Spring (not shown), sensor spring bracing, PVDF sensor, circuit board, sensorLower cover, skin contact, skin contact cap. Wherein sensor spring bracing and diagnosis by feeling the pulse sensor arrayFeed screw nut upper cover in drive mechanism is connected. Sensor spring bracing is connected with circuit board one side,Circuit board opposite side is connected with sensor lower cover one side. PVDF sensor is positioned at sensor spring supportingBetween frame and circuit board. The array hole that sensor contact one side is positioned at sensor spring bracing withPVDF sensor one side is connected, sensor contact opposite side and the battle array that is positioned at sensor spring bracingSpring in row hole is connected. Skin contact is socketed in sensor lower cover array hole, in skin contact, hasOne step, for stopping that skin contact skids off from sensor lower cover. Skin contact one side and PVDF passSensor connects, and opposite side is connected with skin contact cap. Skin contact cap is connected with skin.

Feed screw nut top cap in sensor spring bracing and diagnosis by feeling the pulse sensor array drive mechanismConnect, the spring in diagnosis by feeling the pulse sensor array sonde configuration is enclosed in sensor spring bracing. SensingDevice array is arranged in sensor spring bracing groove (as shown in Figure 8) in certain sequence, circuit board(as shown in Figure 9) by PVDF sensor clamping sensor spring bracing, sensing on circuit boardDevice contact just in time with sensor spring bracing groove in PVDF sensor matching, complete electrical connection.This kind of mechanical grip mode, solves the unweldable problem of PVDF, and sensor pin and circuitPlate pad machinery close contact is better than sensor conducting adhesive cloth connected mode.

Spring in sensor spring bracing contacts PVDF sensor by sensor contact, for passingSensor provides buffering and precompression. Skin contact cap is used for increasing skin contact contact area, and skin touchesPulse wave fluctuation is transmitted in some cap and skin contact combination and then extruding PVDF sensor is realized pulse wave-waveMoving detection. This structure makes each sensor be independent of other sensors by spring buffer, can not causePulse wave will fluctuate conduction to feed screw nut upper cover by a certain point sensor, and then disturb all sensingsThe problem of device. In this structure, sensor array can fluctuate by large-range measuring pulse wave, for building large chiDegree pulse wave provides data basis, also provides data foundation for automatically identifying " cun, guan and chi, three places at the wrist where the pulse is usually taken ".

Two word line laser light sources are connected with bull support both sides respectively, and this light source sends a word line and swashsLight, facilitates patient that one word line laser is mated with rasceta, and then auxiliary diagnosis by feeling the pulse sensor array probeBe placed into assigned address.

Diagnosis by feeling the pulse sensor array drive mechanism one end is connected with Universal arm, the other end and diagnosis by feeling the pulse array sensingDevice is connected, and this diagnosis by feeling the pulse sensor array drive mechanism is motor lead-screw drive mechanism, for surveying pulseTime continuously adjustable pressure, its pressure limit are provided is between 0-300 gram force scope, realize floating, in,Heavy three kinds of diagnosis by feeling the pulse pressure states. By the non-blocking-up pressuring method of diagnosis by feeling the pulse sensor array drive mechanism, canBring extra pressure experience to avoid blocking type to pressurize to patient, avoid because blocking-up pressurization affects bodyLevy parameter, disturb pulse wave collection accuracy.

As shown in Figure 6, diagnosis by feeling the pulse sensor array drive mechanism comprises stepper motor, flange, spring (figureIn do not mark), spline, frictional disk 1, frictional disk 2, thrust bearing, leading screw, feed screw nut upper cover.Flange is connected for support structure with stepper motor, and motor shaft is connected with spline, spline and frictional disk 1In internal spline be connected. Spring one end withstands on stepper motor, and the other end withstands on frictional disk. FrictionCoil 2 one end and frictional disk 1 frictional connection, frictional disk 2 other ends are by jackscrew and the locking of leading screw one endConnect. Thrust bearing is socketed in flange inner side and is connected with frictional disk 2. Leading screw and feed screw nut top capConnect.

Wherein stepper motor rotation passes to frictional disk 1 by spline, the internal spline of frictional disk 1 and flowerKey can produce and slide axially. Spring one side withstands on stepper motor, and opposite side is close to frictional disk 1Frictional disk 2, drives leading screw rotation thereby frictional disk 2 is rotated by frictional drive. Thrust bearing holdsEliminated between frictional disk 2 and flange by axial thrust that rotor is in operation rubs. Feed screw nut upper coverBe connected and change rotatablely moving of leading screw into rectilinear motion with leading screw, in addition feed screw nut upper cover and followingDiagnosis by feeling the pulse sensor array probe be connected.

This drive mechanism is protected human body by frictional drive, in the time that motor is out of control, and feed screw nut top capWhen the diagnosis by feeling the pulse sensor array probe connecing gives human body certain pressure, frictional disk 1 is relative with frictional disk 2Skid, the diagnosis by feeling the pulse sensor array probe vertical motion that stops feed screw nut upper cover to connect, and then preventCause the injury to patient because motor is out of control.

By motor part, to wrist, pressurization realizes " heavy getting " to diagnosis by feeling the pulse sensor array drive mechanism, gets rid ofAbandon the blocking type of traditional and inflating pressure fixing based on Wrist belt-type and measured structure, sensor is disobeyedInvest wrist surface, the fixing and pressure method of having avoided tradition to be attached to wrist brings additionally to patientPressure experience, also avoided the physical sign parameters that brings because occluding pressure is excessive to change, affect pulseRipple collection accuracy.

Wrist support is connected with diagnosis and treatment table for supporting patient's wrist and arm, and its U-shaped structure is for pastingClose patient's arm. There is a cylindrical protrusions U-shaped structure lower end, with the cylinder shape groove phase of diagnosis and treatment tableJoin, this structure can make the adjustment of wrist support travel direction. Wrist supporting structure is better than nonmetal on the marketWrist pillow, nonmetal structure material all has larger elasticity, and wrist and arm contact-making surface are had necessarilyPressure, long-time use causes patient's wrist joint to ache, and not easy cleaning and sterilization. Wrist is propped upThe U-shaped surface of shelf structure is fitted with one deck heating film, for uniform temperature being provided to wrist support, carriesHigh patient uses level of comfort.

As shown in figure 10, the circuit structure of Chinese medicine pulse-taking system health service platform comprises difference closed loopSampling system circuit, this difference closed loop sampling system circuit comprises difference closed loop sample circuit (dotted line frameIn) and peripheral circuit. Peripheral circuit comprises motor overcurrent protection circuit, electric machine spacing circuit, motorDrive circuit, wrist support heated at constant temperature drive circuit, temperature sensor circuit, serial communication circuit,Rectifying and wave-filtering and mu balanced circuit.

Difference closed loop sample circuit comprises diagnosis by feeling the pulse sensor array and signal processing unit, and signal is processed singleUnit comprises preposition differential charge amplifying circuit, 4 rank Butterworth LPF, closed loop feedback systemWith the circuit such as ADC/DAC of supporting generating positive and negative voltage output.

Diagnosis by feeling the pulse sensor array one end is connected with diagnosis by feeling the pulse sensor array drive mechanism, the other end and differenceThe signal processing unit of closed loop sampling system is connected, for gathering patient's pulse wave and passing by cableThe electrical signal transfer of sensor conversion is to difference closed loop sampling system. Chinese medicine pulse-taking system health service platformDifference closed loop sampling system circuit (in figure not mark) by diagnosis by feeling the pulse sensor array collection signal,The other end is connected with computer. Difference closed loop sampling system circuit is placed in diagnosis and treatment table, signal whereinProcessing unit is used for the signal of reception & disposal diagnosis by feeling the pulse sensor array, and by the signal of telecommunication transmission of handling wellTo computer host computer, the data of obtaining are sent to the storage of pulse wave spectrum cloud and cloud processing by host computerPlatform, utilizes cloud computing to carry out choosing of later stage illness coupling and therapeutic scheme.

Diagnosis by feeling the pulse sensor array can adopt flexible material sensor array, wherein preferably adopts PVDFSensor array. As shown in Fig. 3 A, 3B, diagnosis by feeling the pulse sensor array according to cun upper, cun,guan,chi,Under chi, diagnose goldstandard design sensor array column position, because patient's pulse position is departed from Healthy People conventionallyPulse position, so the present invention adopts on very little, cover more than one under cun,guan,chi, chiThe sensor array of point, so that all detect the pulse signal of all possible positions. Of the present inventionSensor array adopts positive 25 dot structures, or positive 24 points+discrete 1 dot structure (discrete 1Point does not mark in the drawings, picks out by flexible wire, can need determine position according to operating personnel),Wherein positive 25 dot structures, according under cun upper, cun,guan,chi, chi, are set up 5 × 5 25 lattice arrays,Its arrangement mode effectively will be cun upper, large area covers under cun,guan,chi, chi; Above-mentioned dot-matrix arrayIn, all dot matrix can be set as equidistantly, also can require to be set as according to the different schools of cun, guan and chi, three places at the wrist where the pulse is usually takenUnequal-interval. The thought of positive 24 points+discrete 1 dot structure on very little, under cun,guan,chi, chi refers toLead down, change 3 × 8 arrangement mode into, increased the lateral length under cun upper, cun,guan,chi, chi,Shorten its longitudinal length, be applicable to a certain elongated area to carry out precision collection; Its discrete 1 knotStructure is free on positive 24 dot structures, for detection of this special circumstances of ectopic radial pulse.

Confirm through overtesting, in above-mentioned two kinds of diagnosis by feeling the pulse sensor arraies, some line space is sensor point range1.5 times to 3 times effects of spacing are better.

As a preferred embodiment, difference closed loop sample circuit comprises 25 road PVDF pressure sensingsDevice, the 25 preposition differential charge amplifying circuits in tunnel, 25 tunnel 4 rank Butterworth LPF, 25 tunnelsAdder, 25 tunnel analog-to-digital conversion, No. 25 followers, 25 tunnel digital-to-analogue conversion current potential benchmark Circuit tunings,Digital-to-analogue conversion chip select circuit, analog-to-digital conversion chip select circuit and micro-processing and control element (PCE).

In concrete enforcement, it is poor that side circuit is realized by 38 roads and 4 groups, 1 Ge Yi road signal pathDivide closed loop sampling functions, because 25 tunnel functional structures are identical, only carry out merit for one group of signal pathCan describe.

The output of PVDF pressure sensor is connected with the input of preposition differential charge amplifying circuit, frontThe output of putting differential charge amplifying circuit is connected with 4 rank Butterworth LPF inputs.

PVDF pressure sensor is converted into the quantity of electric charge pulse wave pressure and passes to preposition differential charge and putLarge circuit, the quantity of electric charge that preposition differential charge amplifying circuit produces PVDF pressure sensor is furtherBe converted into voltage, and do differential amplification, wherein differential amplification function can be eliminated a part effectivelyCommon-mode signal noise. 4 rank Butterworth LPF are all smoother in passband and stopband, withThe slope of 24db/ frequency multiplication by signal amplitude decay more than 30Hz, makes pulse wave signal clear effectivelySeparate.

In a preferred embodiment, as shown in figure 11, one group of preposition differential charge amplifying circuit bag(impedance ranges is for being more than or equal to 10 to draw together high input impedance operational amplifier U3¹²Ohm), high accuracy,Zero shift, low noise rail-to-rail output operational amplifier U2B, resistance R 1, R2, R5, R6, R15,R18, R19, capacitor C 1, C2, C6, C12, plug J1, J2. 2 ends of J1 and GND phaseConnect, the inverting input of U3A is connected with 1 end of J1, one end of C1, one end of R1, U3AOutput be connected with the other end of C1, the other end of R1, the in-phase input end of U3A and R6'sThe in-phase input end of one end, U3B is connected, and the other end of R6 is connected with GND. U3B's is anti-phaseInput is connected with 1 end of J2, one end of C12, one end of R19, the output of U3B and C12The other end, the other end of R19, one end of R15 is connected, 2 ends of J2 are connected with GND. U2BInverting input be connected with one end of R2, one end of R5, another of the output of U2B and R2End is connected, and the in-phase input end of U2B is connected with one end of the other end of R15, R18, and R18's is anotherOne end is connected with GND. 4 ends of U3A are connected with-5V, C2 one end, the other end of C2 and GNDBe connected, 8 ends of U3A are connected with+5V, C6 one end, and the other end of C6 is connected with GND, U2B11 ends be connected with-5V, C3 one end, the other end of C3 is connected with GND, 4 ends of U2B with+ 5V, C8 one end are connected, and the other end of C8 is connected with GND.

Wherein U3, C1, R1, J1 and C12, R19, J2, two preposition electric charges of R6 composition amplifyDevice, for converting PVDF polarization charge to voltage, C1, C12 electric capacity become ratio with PVDF electric capacityExample, R1, R19 have determined amplifier feedback degree and output amplitude sensitivity. R5, R15, R2, R16,U2B forms subtracter, and two charge amplifier output valves are done to subtraction.

Output and the 8 road additions of No. 8 low pass filters in 25 tunnel 4 rank Butterworth LPFThe input of device is connected, 16 analog-to-digital data of the parallel input in the output of 8 tunnel adders and 8 tunnelsSignal input part is connected.

In a preferred embodiment, 4 rank Butterworth LPF comprise high accuracy, zero shift,The U2C of low noise rail-to-rail output operational amplifier and U2D, R7, R8, R12, R16, R9,R10, R17, R13, C4, C10, C11, C5. R7 one end is connected with U2B, another of R7End is connected with one end of one end C10 of R8, the in-phase input end of U2C and the other end of R8, C4One end be connected, the C4 other end is connected with GND, the reverse input end of U2C and one end of R12,One end of R16 is connected, and the other end of R16 is connected with GND, and the output of U2C and R12's is anotherThe other end of one end, C10 is connected, and R9 one end is connected with U2C, one of the other end of R9 and R10One end of end C11 is connected, the in-phase input end of U2D and the other end of R10, and one end of C5 is connected,The C5 other end is connected with GND, one end of the reverse input end of U2D and one end of R13, R17Be connected, the other end of R17 is connected with GND, the output of U2D and the other end of R13, C11The other end be connected.

Wherein R7, R8, R12, R16, C4, C10 and R9, R10, R13, R17, C5,C11 is fine into two second-order low-pass filters, forms quadravalence by change R12, R16, R13, R17Butterworth LPF. R7, R8, C4, C10 and R9, R10, C5, C11 determine filterRipple device cut-off frequency.

8 tunnel adders have two inputs, and an input is through 4 rank Butterworth LPFsThe pulse wave signal of device, another input is that 8 tunnels, 16 digital-to-analogue conversion current potential benchmark of parallel input are adjustedThe analog voltage that whole circuit output end provides, this voltage be used for proofreading and correct each PVDF pressure sensor andThe systematic error that processing technology causes. 8 tunnel adders are by after the stack of two-way voltage input signal and amplifyingInput to 16 analog-to-digital conversion of the parallel input in 8 tunnels, 8 tunnels, 16 analog-to-digital conversion of parallel input will be simulatedVoltage transitions is corresponding data signal.

In a preferred embodiment, a wherein road of 8 tunnel adders comprise high accuracy, zero shift,U2A, R3, R4, R11, the R14 of low noise rail-to-rail output operational amplifier. One end of R11Be connected with U2D, one of one end of the in-phase input end of U2A and the other end of R11, R4, R3End is connected, and the output of U2A is connected with the other end of R4, the reverse input end of U2A and R14'sOne end is connected, and the other end of R14 is connected with GND.

Adder is mainly by the signal plus of the signal of filtering and follower output.

Follower comprises high accuracy, zero shift, low noise rail-to-rail output operational amplifier U4A.The inverting input of U4A is connected with U4A output, and the in-phase input end of U4A and 8 tunnels are parallel defeatedEnter 16 digital-to-analogue conversion current potential benchmark Circuit tunings one of them output be connected, U4A output withThe other end of R3 is connected, and its major function is impedance before and after isolation.

16 the analog-to-digital controls of parallel input of 8 tunnels and data-signal end and micro-processing and control element (PCE)Be connected for 16 the analog-to-digital controls of parallel input of 8 tunnels and data-signal end, micro-processing controlThe part control output end of unit is connected with the input of digital-to-analogue conversion chip select circuit, the choosing of digital-to-analogue conversion sheetThe control output end of circuit connects respectively 16 analog-to-digital CEs of 3 group of 8 parallel input in tunnelInput.

16 digital-to-analogue conversion current potential benchmark Circuit tunings of the parallel input in micro-processing and control element (PCE) and 8 tunnels, 816 analog to digital conversion circuit data-signal exchanges of the parallel input in road adopt bussing technique (example in Figure 10-14As adopt thick black line to represent). Micro-processing and control element (PCE) and digital-to-analogue conversion chip select circuit, analog-to-digital conversion sheetSelect circuit control signal exchange to adopt bussing technique. This technology facilitates similar multimode expansion.

In a preferred embodiment, as shown in figure 12,16 analog-to-digital conversion electricity of the parallel input in 8 tunnelsRoad comprises the positive and negative input analog-to-digital converter U5 of multichannel, 3-8 line decoder U7, filter capacitor C13,C14, C15, C16, C17, decoupling capacitor C18, C19, C20, C21, filter capacitor C22,C23, C24, C25, C26, resistance R 20, R21, R22, R24, R25, R26, terminalsJ4, J3, J6, J8, wire jumper row SW1.

C18 one end is connected with the input 43 of U5, input 46 and the mould of the C18 other end and U5Intend ground and be connected, C19 one end is connected with the input 50 of U5, the input of the C19 other end and U553 be connected in analog, C20 one end is connected with the input 63 of U5, the C18 other end and U5'sInput 60 be connected in analog, C21 one end is connected with the input 6 of U5, the C18 other end withThe input 3 of U5 be connected in analog, input 36 ends of U5 are connected with one end of R24, R24The other end be connected in analog, R25 one end is connected with one end of HVDD and C23, R25 is anotherOne end is connected with simulation positive supply 48 ends of U5 and one end of C24, the other end of C23 with in analogBe connected, the other end of C24 be connected in analog. R26 one end is connected with one end of HVSS and C22,The R26 other end is connected with simulation negative supply 1 end of U5 and one end of C25, the other end of C22 withIn analog be connected, the other end of C25 be connected in analog. One end of C26 and the output of U5 56End is connected, the other end of C26 and the input of U5 55 ends be connected in analog. U5 in analog5 ends, 15 ends, 44 ends, 51 ends, 58 ends, 62 ends and be connected in analog, digitally 24 of U5End, input 34 ends, 41 ends, 8 ends and be digitally connected, be connected in analog with digitally.

33 ends of U5 are connected with 1 end of J6, and 32 ends of U5 are connected with 2 ends of J6, U5's31 ends are connected with 3 ends of J6, and 30 ends of U5 are connected with 4 ends of J6,29 ends and the J6 of U55 ends be connected, 28 ends of U5 are connected with 6 ends of J6,27 ends of U5 are connected with 7 ends of J6,26 ends of U5 are connected with 8 ends of J6, and 23 ends of U5 are connected with 9 ends of J6,22 ends of U5Be connected with 10 ends of J6,21 ends of U5 are connected with 11 ends of J6,12 of 20 ends of U5 and J6End is connected, and 19 ends of U5 are connected with 13 ends of J6, and 18 ends of U5 are connected with 14 ends of J6,17 ends of U5 are connected with 15 ends of J6, and 16 ends of U5 are connected with 16 ends of J6.

Input 10 ends of U5 and one end of R22 and one end of J4, the other end of R22 and numeralGround is connected, and the other end of J4 is connected with IOVDD. 9 ends of U5 are connected with IOVDD, U5'sInput 37 ends are connected with 1 end of J3, and input 38 ends of U5 are connected with 2 ends of J3, U5Input 39 ends be connected with 3 ends of J3, input 40 ends of U5 are connected with 4 ends of J3,Output 35 ends of U5 are connected with 6 ends of J3, one of 12 ends of U5 and 5 ends of J3 and R21End is connected, and the other end of R21 is connected with IOVDD, interface power supply 25 ends and the IOVDD phase of U5Connect, input 13 ends of U5 and 1 end of SW1,2 ends, 3 ends, 4 ends, 5 ends, 6 ends, 7 ends,8 ends are connected, and 16 ends of SW1 are connected with 15 ends of U7,15 ends of SW1 and 14 ends of U7Be connected, 14 ends of SW1 are connected with 13 ends of U7, and 13 ends of SW1 are connected with 12 ends of U7,12 ends of SW1 are connected with 11 ends of U7, and 11 ends of SW1 are connected with 10 ends of U7, SW110 ends be connected with 9 ends of U7,9 ends of SW1 are connected with 7 ends of U7. The input of U52,7,42,47,49,54,59, the output of 64Yu eight tunnel adders is connected.

Wherein 16 analog-to-digital conversion of the parallel input in 8 tunnels comprise the positive and negative input analog-to-digital converter U5 of multichannel,Decoder U7, filter capacitor C13, C14, C15, C16, C17, decoupling capacitor C18, C19,C20, C21, filter capacitor C22, C23, C24, C25, C26, resistance R 20, R21, R22,R24, R25, R26, terminals J4, J3, J6, J8, SW1. Resistance R 20, R21, R22,8,9,34,41 ends of R24 and U5 arrange hard that ADCU5 chip operation transmits at parallel outputPart pattern. J3 walks abreast and inputs the state control bus port of 16 analog-to-digital conversion modules as 8 roads,Can carry out module expansion of the same race. Input channel and read states control end that the 1-6 end of J3 is ADC,The 7-10 end of J3 is this group ADC CE port. The 7-10 end of J3 is by the decoding of 3-8 lineDevice U7 distributes 8 gating addresses, and wire jumper row SW1 can be communicated with as this modules A DC on an optional roadGating branch road. Therefore J3 can support eight module parallel joins of the same race. The 1-16 end of J6 is this mouldThe data input bus (DIB) port of piece, can support eight module parallel joins of the same race. C22, R26, C25With C23, R25, the filtering of C24 composition π type, be used to HVSS and HVDD filtering, C18, C19,C20, C21 are decoupling capacitor, and C13, C14, C15, C16, C17 are power filtering capacitor.The input 2,7,42,47,49,54,59 of U5, the output of 64Yu eight tunnel adders are connectedFor receiving the analog signal that analog circuitry processes is crossed.

As shown in figure 13,16 digital-to-analogue conversion current potential benchmark Circuit tunings of the parallel input in 8 tunnels comprise manyThe positive negative output analog-digital chip of passage U8, test point TP1, TP2, TP3, TP4, resistance R 28,R29, R30, R31, R32, R33, R34, four-bis-input in the same way or door U9, the decoding of 2-4 lineDevice U10, d type flip flop U11, bus transceiver U12, two inputs and door U13, terminals J8,J9、SW2。

Digitally 22,26,46 ends of U8 be digitally connected, interface power supply 47 ends of U8 withIOVDD is connected, and digital power 21,48 ends of U8 are connected with DVDD, U8 in analog 9,33 ends be connected in analog, reference power source 6,36 ends of U8 are connected with REF, the simulation of U8 is negativePower supply 11,31 ends are connected with AVSS2, and simulation positive supply 8,34 ends of U8 are connected with AVDD2.

Output 15 ends of U8 are connected with 9 ends of R28 one end, terminals J8, and R28's is anotherOne termination IOVDD, 1 phase of the bi-directional data end 27 of U8 and R29 one end, test port TP3Connect, the other end of R29 is connected with IOVDD, input 14 ends of U8 be connected in analog, U8Input 28 ends be connected with one end of R30, the other end of R30 is connected with IOVDD, U8'sInput 16 ends and U10A output 6 ends, one end of R32 is connected, the other end of R32 and IOVDDBe connected, input 18 ends of U8 and output 7 ends of U10A, one end of R33 is connected, R33The other end be connected with IOVDD, input 50 ends of U8 are connected with the output 3Y of U9,Input 17 ends of U8 and the output 4 of U13, one end of R31 is connected, the other end of R31 withDigitally be connected, 49 ends of U8 are connected with the output 5 of U10A.

Bi-directional data end 20,19,25,24,23 ends of U8 respectively with the output 2,5 of U11,6,9,12 be connected, input 3,4,7,8,13 ends of U11 and terminals J9 1,2,3,4,5 ends, bi-directional data end 2,3,5,6,8 ends of U12 are connected, the bi-directional data end 9 of U12,11,6,7,8,9 of 12,13,14,16,17,19,20,22,23 ends and terminals J9,10,11,12,13,14,15,16 ends.

The bi-directional data end of U12 2,3,5,6,9,11,12,13,14,16,17,19,20,22,23 ends, the bi-directional data end 33,32,31,30,29,28,27,26,23 of U5,22,21,20,19,18,17,16 ends, J6 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 ends, the bi-directional data end 81,82,83,84,85,86 of U6,87,88,55,56,57,58,59,60,61,62 ends are connected. U12 digitally 4,10,15,21,28,34,39,45 be digitally connected, the bi-directional data end of U12 26,27,29,30,32,33,35,36,37,38,40,41,43,44,46,47 ends and U8's is two-wayData terminal 39,40,41,42,43,44,45,51,52,53,54,55,56,1,2,3 ends are connected.

25,48 ends of U12 input and 1,3,5,7 ends of SW2 and the input 3A of U9CBe connected, output 9,10,11,12 ends of U10B are connected with 2,4,6,8 ends of SW2,The 3B input of U9C is connected with the output 2Y of U9B, input 1,24 and the U10A of U12Output 5 ends be connected. The input 2A of U9B is connected with 3 of terminals J8, and U9B's is defeatedEnter to hold the input 1B of 2B and U9A, terminals J8 2 be connected, the input 1A of U9A withThe output 4 of U10A is connected, and the output 1Y of U9A is connected with the input 11 of U11, U11The input 1 of input 1 and U10A, the input 15 of U10B, the 1 end phase of terminals J8Connect. 4 of J8 is connected with the input 2 of U10A, and 5 of J8 is connected with the input 3 of U10A,6 of J8 is connected with the input 14 of U10B, and 7 of J8 is connected with the input 13 of U10B, J88 be connected with the input 2 of U13.

Wherein, J8 is as the state of 16 digital-to-analogue conversion current potential benchmark Circuit tunings of the parallel input in 8 tunnelsWhat U8 was controlled in control bus port and U9, U10A, U13 combination is operated in parallel transmission Working mouldFormula. Wherein, resistance R 28, R29, R30, R31, R32, R33, R34, respectively with U8's15,27,28,17,16,18 are connected for configuring the duty of U8DAC. 1,2 of J8The Strobe input 50 of the 1 end control U8 of end, U9B, U9C, U10B. 1,4,5 of J8End and U10A control respectively zero clearing, reset, the read-write control end of U8. 6,7 ends of J8 pass through2-4 line decoder U10B distributes 4 gating addresses, and wire jumper row SW2 can join in an optional road connectionClose 10 ends of U9C as the gating branch road of this module DAC. Therefore J8 can support four moulds of the same racePiece parallel join. 8 ends of J8 and U13 control latch control end 17 ends of DAC. 2 ends of J8,Output 4 ends of 2-4 line decoder U10A and U9A control latch input terminal 11 ends of U11.The duty of latch input terminal 11 ends of U11 and the 1 end control U11 of J8. D type flip flop U11For the signal of latch control U8 address date, this signal is from J5. 5 of U10B and U10AEnd is controlled the duty of U12, and U12, for bi-directional transfer of data signal, realizes dividing of multiple signalsIn time, transmits. J5 as the data of 16 digital-to-analogue conversion current potential benchmark Circuit tunings of the parallel input in 8 tunnels andAddress bus port, for U8 transmits data and address signal. J5 can support four modules of the same race parallelConnect. The output 5,7,10,13,29,32,33,37 of U8 respectively with No. 8 follower phasesConnect, for sending by No. 8 followers the analog voltage of processing to 8 tunnel adders.

8 tunnels, 16 analog to digital conversion circuits of parallel input and 16 digital-to-analogue conversion current potentials of the parallel input in 8 tunnelsThe ADC adopting in benchmark Circuit tuning and the sample frequency of DAC are all at hundreds of K, to pulse signalRealize over-sampling, effectively reduce and quantize noise power spectrum.

Micro-processing and control element (PCE) enters 16 the analog-to-digital controls of parallel input of 8 tunnels and data-signalRow is processed, and micro-processing and control element (PCE) is by 16 analog-to-digital data letters of parallel 8 tunnels input on the one handNumber send computer to by serial communication circuit, on the other hand, micro-processing and control element (PCE) is by controllingAnalog-to-digital conversion chip select circuit carries out gating control to 16 analog to digital conversion circuits of four groups of parallel inputs, makesNeed 8 tunnels to be processed, 16 analog-to-digital conversion signals of parallel input as required data to be sent toMicro-processing and control element (PCE).

Micro-processing and control element (PCE) adjust electricity for 8 tunnels, 16 digital-to-analogue conversion current potential benchmark of parallel input16 digital-to-analogue conversion current potential benchmark Circuit tunings of the parallel input in the control on road and data-signal end and 8 tunnelsControl and the signal end of data be connected, 8 tunnels, 16 digital-to-analogue conversion current potential benchmark of parallel input are adjusted electricityRoad analog voltage output is connected with the input of No. 8 followers, the output of No. 8 followers and phaseThe input of 8 corresponding tunnel adders is connected, part control output end and the digital-to-analogue of micro-processing and control element (PCE)The input of conversion chip select circuit is connected, and the control output end of digital-to-analogue conversion chip select circuit connects respectively 3Organize the CE input of 16 digital-to-analogue conversion current potential benchmark Circuit tunings of the parallel input in 8 tunnels.

The data signal that micro-processing and control element (PCE) is crossed algorithm process sends 16 of the parallel inputs in 8 tunnels toDigital-to-analogue conversion current potential benchmark Circuit tuning, 8 tunnels, 16 digital-to-analogue conversion current potential benchmark of parallel input are adjusted electricityRoad generates analog voltage signal according to the data signal transmitting, and sends analog voltage signal to 8 tunnelsFollower. No. 8 followers, for impedance transformation, are avoided 16 digital-to-analogue conversion current potentials of the parallel input in 8 tunnelsBenchmark Circuit tuning is directly connected and causes impedance mismatch with 8 tunnel adders.

Micro-processing and control element (PCE) is by controlling digital-to-analogue conversion chip select circuit, to 16 of four groups of parallel inputsDigital-to-analogue conversion current potential benchmark Circuit tuning carries out gating control, makes to need the analog voltage signal energy of transmissionEnough be sent to as required corresponding 8 tunnel adders.

The multiple spot array of PVDF pressure sensor of the present invention further comprises following datum error schoolPositive flow process:

Force value of given sensor array group in sometime, force value is by preposition differential electricalLotus amplifying circuit, 4 rank Butterworth LPF enter 16 analog-to-digital conversion electricity of the parallel input in 8 tunnelsRoad, this force value is converted into digital quantity and enters micro-processing and control element (PCE), and micro-processing and control element (PCE) will be processedThe information of crossing is sent into 16 digital-to-analogue conversion current potential benchmark Circuit tunings of the parallel input in 8 tunnels, processesData signal is converted into analog signal and is added in 8 tunnel adders by No. 8 followers and primary signalRevise, 8 tunnel adders are further sent correction value into 16 analog to digital conversion circuits of the parallel input in 8 tunnels.This circulation process reaches unanimity the magnitude of voltage of each sensor in array.

In a preferred embodiment, as shown in figure 14, micro-processing and control element (PCE) circuit comprises micro-controlDevice U6 processed, terminals J5, J7, resistance R 23, R27, capacitor C 27, C28, C29, C30,Crystal oscillator Y1, Y2.

Bi-directional data end 1,2,3,4 ends of U6 and the input 1,2,3,6 of U7 and J3 7,8,9,10 are connected, the input 6 of U6, interface power supply 11,21,22,28,50,75,100Be connected with IOVDD. The input 8 of U6 and one end of Y1, one end of C27 is connected, and U6's is defeatedEnter end 9 and the other end of Y1, one end of C28 is connected, the other end of C27, C28 and phase digitallyConnect. U6 digitally 10,19,20,27,74,99 be digitally connected. The input of U612 with one end of Y2, one end of C29 is connected, the input 13 of U6 and the other end of Y2, C30One end be connected, the other end of C29, C30 be digitally connected, the bi-directional data end of U6 37 andR27 be connected, the other end of R27 be digitally connected. The bi-directional data end 38,39,40 of U6,41,42,43,44,45,46 are connected with 1,2,3,4,5,6,7,8,9 of J8, U6Bi-directional data end 47,48,51,52,53,54 be connected with 1,2,3,4,5,6 of J3.The bi-directional data end output 68 of U6 is connected with 2 of J7, the bi-directional data end output 69 of U6Be connected with 1 of J7, the bi-directional data end 72 of U6 is connected with 7 ends of J5, the bi-directional data of U6End 76 is connected with 9 ends of J5, and the bi-directional data end 77 of U6 is connected with 5 ends of J5, and U6's is twoBe connected with 13 ends of J5 to data terminal 89, the bi-directional data end 90 of U6 is connected with 3 ends of J5,The bi-directional data end 14 of U6 is connected with 15 ends of J5. The bi-directional data end 55,56,57 of U6,58,59,60,61,62,81,82,83,84,85,86,87,88 and the 1-16 end of J9,The output 2,3,5,6,8,9,11,12,13,14,16,17,19,20,22 of U12,23 ends, U5 16,17,18,19,20,21,22,23,26,27,28,29,30,31,32,33 ends, the 1-16 end of J6 is connected.

Wherein, U6 is mainly by providing data and control signal for ADC and DAC, and its bus is dividedFor data/address bus, ADC control bus and DAC control bus. U6 by 55,56,57,58,59,60,61,62,81,82,83,84,85,86,87,88 ends are to ADC and DACData signal, by the work shape of 1,2,3,4,51,52,53,54 ends transmission ADCState control signal, transmits DAC's by 38,39,40,41,42,43,44,45,46 endsWorking state control signal. 14,72,76,77,89,90 ends of U6 are connected for journey with J5Order programming debugging. 68,69 ends of U6 are connected and for U6, host computer are communicated by letter with J7.

Motor overcurrent protection circuit is for detection of motor rotation blockage signal, when driven by motor transmission mechanism runs intoWhen resistance stall, when human body bears larger pressure, motor overcurrent protection circuit sends signal to micro-Processing and control element (PCE), micro-processing and control element (PCE) quits work motor by motor-drive circuit, and thenThe pressure that protection human body is not caused by motor overexercise injures. Reset motor circuit is for detection of motorOriginal position. The output of motor overcurrent protection circuit and reset motor circuit and micro-processing and control element (PCE)Part control input end be connected, micro-processing and control element (PCE) part control output end and motor-drive circuitInput is connected, and motor-drive circuit output is connected with motor.

Wrist support heated at constant temperature drive circuit is used for driving heating film, and heating film can be ensured necessarilyTemperature, provides a comfortable testing environment to patient. Temperature sensor circuit is used for testing heating filmTemperature, gives micro-processing and control element (PCE) by data feedback, and micro-processing and control element (PCE) can be controlled accuratelyWrist support heated at constant temperature drive circuit works, makes temperature control form closed loop. Temperature sensor circuitOutput be connected with micro-processing and control element (PCE) partial data input, the part of micro-processing and control element (PCE)Control output end is connected with the control input end of wrist support heated at constant temperature drive circuit, wrist support perseveranceThe control output end of temperature heat driven circuit is connected with heating film.

Serial communication circuit mainly sends the information of micro-processing and control element (PCE) processing to computer. Micro-placeReason control module communication output is connected with serial communication circuit input, serial communication circuit outputBe connected with computer.

Rectifying and wave-filtering and mu balanced circuit are for providing stable power supply supply. For unit circuit,Power supply circuits of the present invention adopt the pattern of power supply respectively, to avoid impact each other.

In a preferred embodiment, as shown in figure 15, rectifying and wave-filtering and mu balanced circuit comprise inductanceL1, L2, L3, L4, L5, L6, L7, L8, L9 filter capacitor C31, C32, C33, C34, C35、C36、C37、C38、C39、C40、C41、C42、C43、C44、C45、C46、C47、C48、C49、C50、C51、C52、C53、C54、C55、C56、C57、C58、C59、C60、C61、C62、C63、C64、C65、C66。

L1 one end and C35 one end ,+HV is connected, the other end of L1 and C31, C36, C37,C38, HVDD1 are connected, and another termination of C35, C31, C36, C37, C38 in analog.

L3 one end and C39 one end ,-HV is connected, the other end of L3 and C40, C41, C42, C43,HVSS1 is connected, and another termination of C39, C40, C41, C42, C43 in analog.

L5 one end and C47 one end ,+HV is connected, the other end of L5 and C48, C49, C50,C51, HVDD2 are connected, and another termination of C47, C48, C49, C50, C51 in analog.

L7 one end and C55 one end ,-HV is connected, the other end of L7 and C56, C57, C58, C59,HVSS1 is connected, and another termination of C55, C56, C57, C58, C59 in analog.

One end of L2 is connected with+5VD, one end of the other end of L2 and C32, C33, C34, DVDDBe connected, the other end of C32, C33, C34 be digitally connected.

One end of L4 is connected with+5VA, one end of the other end of L4 and C44, C45, C46, DVDDBe connected, the other end of C44, C45, C46 be digitally connected.

One end of L6 is connected with+3.3, one end of the other end of L6 and C52, C53, C54, IOVDDBe connected, the other end of C52, C53, C54 be digitally connected.

One end of L8 is connected with+3.3, one end of the other end of L8 and C61, C62, C63, IOVDDBe connected, the other end of C32, C33, C34 be digitally connected.

One end of L9 is connected with+2.5, one end of the other end of L9 and C64, C65, C66, REFBe connected, the other end of C64, C65, C66 be digitally connected.

Filtration module in rectifying and wave-filtering and mu balanced circuit by ADC/DAC chip power supply, with reference to power supply,Interface circuit power supply and other chip power supplies separate by filtration module, reduce between each power supply and disturb.

As shown in figure 16, Chinese medicine pulse-taking system health service platform Internet of Things scheme comprises household portableFormula pulse-taking instrument, doctor's pulse-feeling instrument, the storage of pulse wave spectrum cloud and cloud processing platform, colleges and universities of research institute, diseaseControl center, Chinese medicine plantation business and supplier, third-party logistics, terminal consumer etc.

Domestic portable pulse-taking instrument is connected with the storage of pulse wave spectrum cloud and cloud processing platform, domestic portablePulse-taking instrument by gathering in family, is sent to patient's diagnosis by feeling the pulse data and relevant personal information pulse wave spectrum cloud and depositsStorage and cloud processing platform, the storage of pulse wave spectrum cloud and cloud processing platform are set up individual by the data that transmitHealth data platform and prescription therapeutic scheme, realize patient oneself health control.

Doctor's pulse-feeling instrument is connected with the storage of pulse wave spectrum cloud and cloud processing platform, and doctor's pulse-feeling instrument is by patientDiagnosis by feeling the pulse data and relevant personal information are gathered by hospital, are sent to the storage of pulse wave spectrum cloud and cloud and process flatPlatform, doctor can be by the prescription therapeutic scheme of the storage of pulse wave spectrum cloud and cloud processing platform suggestion and selfThe prescription therapeutic scheme of diagnosis combines, for patient provides diagnosis more accurately, for doctor provides auxiliaryHelp diagnosis and treatment suggestion.

The sustainable record for many years of the storage of pulse wave spectrum cloud and cloud processing platform, preserves and transfers patient data,Ensure patient data integrality and seek medical advice continuity; Can rely on patient data to realize classification diagnosis and treatment, doctorExchanges data and tele-medicine and the consultation of doctors between institute.

The storage of pulse wave spectrum cloud is connected with the scientific research institution such as research institute, colleges and universities with cloud processing platform, forSimilar patient data is analyzed, for research and teaching provides Data support; Can also with Disease Control and Prevention Center's phaseConnect, for realizing based on zonal inferior health and medicine of chronic disease analysis; Can also plant business with Chinese medicineSupplier is connected with Chinese medicine, and Chinese medicine plantation business is connected with third-party logistics with Chinese medicine supplier, third partyLogistics is connected with terminal consumption, is used to Chinese medicine plantation business and Chinese medicine supplier that market demand analysis is providedAnd the accurate delivery of natural resources of Chinese medicinal materials.

Above-described specific embodiment, carries out object of the present invention, technical scheme and beneficial effectFurther description, it should be understood that and the foregoing is only specific embodiments of the invention,Be not limited to the present invention, within the spirit and principles in the present invention all, any amendment of making,Protection scope of the present invention is equal to replacement, improvement etc., within all should be included in.

Claims

1. a difference closed loop sample circuit, is characterized in that, comprising:

2. difference closed loop sample circuit as claimed in claim 1, is characterized in that described diagnosis by feeling the pulseSensor array adopts the flexible material pressure sensor structure of 25 of the five-element's five row of 5 × 5, orThe flexible material pressure sensor structure of 3 × 83 row 8 row 24 points+discrete 1, wherein said fromThe flexible material pressure sensor of loose 1 picks out by flexible wire, can need according to operator andAdjust detection position.

3. difference closed loop sample circuit as claimed in claim 2, is characterized in that described diagnosis by feeling the pulseThe sensor points line space of sensor array is 1.5 times to 3 times of sensor points column pitch.

4. difference closed loop sample circuit as claimed in claim 1, is characterized in that described signalProcessing unit comprises that preposition differential charge amplifying circuit, 4 rank Butterworth LPF, closed loop are anti-The ADC/DAC circuit of feedback system and the output of support generating positive and negative voltage; And

Described signal processing unit has preferably adopted bussing technique.

5. difference closed loop sample circuit as claimed in claim 4, is characterized in that, described inThe sample frequency of ADC/DAC circuit is all between 100-1000KHz scope, to described pulse wave spectrumThe pulse signal that sensor device detects is realized over-sampling.

6. difference closed loop sample circuit as claimed in claim 4, is characterized in that, described prepositionDifferential charge amplifying circuit comprises the first operational amplifier, second operational amplifier of high input impedance,And the first output operational amplifier of zero shift, low noise rail-to-rail; Wherein the first operational amplifierInverting input be connected with 1 end of the first plug, one end of the first electric capacity, one end of the first resistance,The output of the first operational amplifier is connected with the other end of the first electric capacity, the other end of the first resistance,One end of the in-phase input end of the first operational amplifier and the 6th resistance, the homophase of the second operational amplifierInput is connected, and the other end of the 6th resistance is connected with GND; The second operational amplifier anti-phase defeatedEnter end and be connected with 1 end of the second plug, one end of the 12 electric capacity, one end of the 19 resistance, theThe output of two operational amplifiers and the other end of the 12 electric capacity, the other end of the 19 resistance, theOne end of 15 resistance is connected, and 2 ends of the second plug are connected with GND; The first output operation amplifierThe inverting input of device is connected with one end of the second resistance, one end of the 5th resistance, the first output computingThe output of amplifier is connected with the other end of the second resistance, and the homophase of the first output operational amplifier is defeatedEnter end and be connected with the other end of the 15 resistance, one end of the 18 resistance, another of the 18 resistanceEnd is connected with GND; 4 ends of the first operational amplifier are connected with-5V, second electric capacity one end, and secondThe other end of electric capacity is connected with GND; 8 ends of the first operational amplifier and+5V, the 6th electric capacity oneEnd is connected, and the other end of the 6th electric capacity is connected with GND; 11 ends of the first output operational amplifier with-5V, the 3rd electric capacity one end are connected, and the other end of the 3rd electric capacity is connected with GND; The first output computing4 ends of amplifier are connected with+5V, the 8th electric capacity one end, the other end of the 8th electric capacity and GND phaseConnect;

7. difference closed loop sample circuit as claimed in claim 4, is characterized in that described signalProcessing unit comprises preposition differential charge amplifying circuit, 4 rank Butterworth LPF, 8 tunnels also16 adc circuits of row input, micro-processing and control element (PCE), 16 digital-to-analogue conversions of the parallel input in 8 tunnelsCurrent potential benchmark Circuit tuning, No. 8 followers and 8 tunnel adders; And

8. a pulse-taking instrument, is characterized in that, described pulse-taking instrument comprises as claim 1 to 7 timesThe difference closed loop sample circuit of anticipating described in one; And

Described pulse-taking instrument is preferably domestic portable pulse-taking instrument or doctor's pulse-feeling instrument.

9. pulse-taking instrument as claimed in claim 8, is characterized in that, described pulse-taking instrument also comprises handWrist support and peripheral circuit, described peripheral circuit comprises wrist support heated at constant temperature drive circuit and temperatureSensor circuit, described temperature sensor circuit is for detection of propping up for the wrist of shelving tester's wristThe temperature of frame contact site, described wrist support heated at constant temperature drive circuit is for according to described temperatureThe testing result of sensor circuit determines whether ordering about the heating film heating on described wrist support,Use level of comfort to improve patient; And

Described peripheral circuit also comprises rectifying and wave-filtering and mu balanced circuit, described rectifying and wave-filtering and mu balanced circuitBe used to described difference closed loop sample circuit and each peripheral circuit to provide separately respectively stable power supply to supplyShould.

10. a Chinese medicine pulse-taking system health service platform, is characterized in that, comprising:

Pulse-taking instrument as claimed in claim 8 or 9; And

Cloud storage and cloud processing platform, for the testing result of described pulse-taking instrument is carried out to cloud storage, andUtilize cloud computing to carry out choosing of later stage illness coupling and therapeutic scheme.