CN105592799B - Ultrasonic system and method for automating heartbeat identification - Google Patents
Ultrasonic system and method for automating heartbeat identification Download PDFInfo
- Publication number
- CN105592799B CN105592799B CN201480054509.2A CN201480054509A CN105592799B CN 105592799 B CN105592799 B CN 105592799B CN 201480054509 A CN201480054509 A CN 201480054509A CN 105592799 B CN105592799 B CN 105592799B
- Authority
- CN
- China
- Prior art keywords
- mode
- echo data
- spatially different
- line
- mode line
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims abstract description 16
- 210000002458 fetal heart Anatomy 0.000 claims abstract description 54
- 210000003754 fetus Anatomy 0.000 claims abstract description 51
- 238000003384 imaging method Methods 0.000 claims description 14
- 230000015572 biosynthetic process Effects 0.000 claims description 13
- 239000000523 sample Substances 0.000 claims description 13
- 238000003786 synthesis reaction Methods 0.000 claims description 12
- 238000012545 processing Methods 0.000 claims description 6
- 238000003745 diagnosis Methods 0.000 claims description 4
- 238000002592 echocardiography Methods 0.000 claims description 3
- 230000000977 initiatory effect Effects 0.000 claims description 2
- 230000033001 locomotion Effects 0.000 description 14
- 210000003484 anatomy Anatomy 0.000 description 8
- 230000000747 cardiac effect Effects 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 210000005240 left ventricle Anatomy 0.000 description 6
- 238000002604 ultrasonography Methods 0.000 description 6
- 206010000234 Abortion spontaneous Diseases 0.000 description 5
- 230000001605 fetal effect Effects 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 208000015994 miscarriage Diseases 0.000 description 5
- 238000009877 rendering Methods 0.000 description 5
- 208000000995 spontaneous abortion Diseases 0.000 description 5
- 238000011161 development Methods 0.000 description 4
- 230000002194 synthesizing effect Effects 0.000 description 4
- 238000010009 beating Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000004291 uterus Anatomy 0.000 description 3
- 241001269238 Data Species 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000003387 muscular Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 208000036830 Normal foetus Diseases 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000004578 fetal growth Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000010247 heart contraction Effects 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000012913 prioritisation Methods 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000001020 rhythmical effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/02—Measuring pulse or heart rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0866—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving foetal diagnosis; pre-natal or peri-natal diagnosis of the baby
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/46—Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient
- A61B8/461—Displaying means of special interest
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/46—Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient
- A61B8/467—Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient characterised by special input means
- A61B8/469—Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient characterised by special input means for selection of a region of interest
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/486—Diagnostic techniques involving arbitrary m-mode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5207—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of raw data to produce diagnostic data, e.g. for generating an image
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5269—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving detection or reduction of artifacts
Abstract
Ultrasonic system and method provide the workflow of automatic identification fetal heart beat.Area-of-interest (ROI) is identified in ultrasonoscopy and identifies the ROI for including heart of fetus.Ultrasonic system generates and the associated spatially different M-mode lines of ROI.The ultrasonic system can identify fetal heart beat by the position of the variation of tracking heart wall, and for example estimate fetal heart frequency to peak value by measuring the peak value of two adjacent waves.It also can there may be to being ranked up for the echo-signal of M-mode line according to the fetal heart beat in echo data.
Description
Technical field
Ultrasound is very suitable for fetus imaging, because it executes non-invasive imaging, without mother or fetus to be exposed to
Ionising radiation.The purpose that many fetuses check is to assess the development of fetal anatomy structure to judge whether fetus develops normally.By
Improved in these years ultrasonograph quality, therefore the region of more anatomical structures can be visualized in more detail, with
Carry out development evaluation.Therefore, with requiring to increase to anatomical structure to be evaluated, fetal ultrasound inspection has become more complete
Face.One region of the anatomical structure gone through is developmental heart of fetus.
Background technology
Ultrasonic system can be used for detection about gestation five weeks in fetal heart beat.At this point, normal fetus heart rate is similar
The heart rate of mother Yu, for example, about 80-85 times per minute.In next month, heart rate will steadily increase daily every about point
Clock is three times.After further development, healthy fetal heart frequency can be in 120 to 200 (BPM) ranges per minute.Therefore,
If fetal heart beat not in acceptable range, can determine whether the risk of miscarriage using ultrasonic examination.For example,
When being pregnant 6-8 weeks, the relationship between fetal heart frequency and risk of miscarriage shows if fetal heart frequency is less than 70 times per minute, stream
The possibility of production is absolutely.As the heart rate measured increases, the possibility linear reduction of miscarriage, for example, if heart rate is low
In 90 times per minute, the possibility of miscarriage is still very high, and about 86 percent miscarriage may.
In recent years, the efferent tract of heart has become detection and measures the focus of fetal heart frequency.However, it may be difficult to
The heart efferent tract of heart of fetus is imaged and is detected in useful measuring section.For this one the reason is that this
Fetal anatomy structure it is small-sized.Another reason is desirable to not only simply check anatomical structure, and checks entire tire
Pass through the flow behavior of efferent tract dynamic in youngster's cardiac cycle.It is quite big that Another reason is that efferent tract is undergone in fetal growth
Development, therefore can modified appearance and complexity according to the fetus monthly age.Accordingly, it is difficult to identify stream in ultrasound display
It engages in this profession, may be more difficult to be suitably oriented upper acquisition image, fully to detect and/or measure fetal heart beat.
Another problem is fetus frequent activities, and may not keep quiet during the time needed for data acquisition
Only.In F/A, desired image data will change relative to the orientation of probe, and heart of fetus may be complete
Visual field is left, leads to do not have desired anatomical structure in acquired data set.Moreover, the movement of the foetus during acquisition can limit fetus
The accuracy of the measurement of cardiac cycle.Furthermore, it is also possible to be difficult to heart rate by fetal heart frequency and mother and/or other are rhythmic
Background artifact distinguishes.
Therefore, it is necessary to a kind of improvement systems and workflow for clinician so that ultrasonic system is easier to use
And make identification fetal heart beat and measurement fetal heart frequency more accurate.
Invention content
The present invention relates to medical diagnostic systems, and in particular to fetal heart beat for identification and associated heart rate
Ultrasonic diagnosis imaging system.
Principle according to the present invention, a kind of diagnostic ultrasound system have workflow and control, and the control is convenient for identification
Heartbeat (for example, fetal heart beat) and associated heart rate.The workflow is allowed the clinician in tire bud (fetal
Pole) and/or nearby area-of-interest (ROI) is arranged in heart of fetus, then identifies fetal heart beat and/or acquisition fetal heart frequency.
The ultrasonic system is set to be repeatedly scanned with the M-mode line of different orientation associated with area-of-interest automatically.The ultrasonic system
It can identify fetal heart beat and fetal heart frequency is estimated according to the echo-signal received along at least one of M-mode line.?
Echo-signal from M-mode line can be ranked up, for example, to identify the M of the heartbeat in most probable instruction echo data
Mode scans.
Description of the drawings
In the accompanying drawings：
Fig. 1 illustrates the ultrasonic diagnosis imaging system of principle construction according to the present invention in block diagram form.
Fig. 2 illustrates the workflow according to the present invention with measurement fetal heart frequency for identification.
Fig. 3 illustrates the M-mode image of the movement of cardiac muscle.
Fig. 4 illustrates the display of embodiments of the present invention, and image includes the ROI of heart of fetus and folds for identification
Add spatially different M-mode lines, to identify and measure fetal heart frequency.
Fig. 5 illustrates for automatic identification fetal heart beat and measures the technology of fetal heart frequency.
Fig. 6 A illustrate for automatic identification fetal heart beat and measure another technology of fetal heart frequency.
Fig. 6 B are illustrated for measuring fetal heart beat signal by synthesizing the M line numbers evidence from B-mode echo-signal
Technology.
Specific implementation mode
The present invention provides the system and method for (for example, the fetal heart beat) and associated heart rate of heartbeat for identification.For example,
The system and method can be used in reducing the sweep time of Sonographer, improves diagnosis confidence level and simplifies for sweeping
Retouch the workflow of pregnant and lying-in women patient.
In one embodiment, the present invention includes the ultrasound of a kind of bud of tire for identification or heart and/or associated heart rate
Imaging system.The system of the present invention includes ultrasonic probe.A variety of probes can be used, and can include array energy transducer.This is
System further includes the image processor for handling the echo data from probe.Echo data can include by multiple imaging pattern (examples
Such as B-mode or M moulds image collection type) obtain echo-signal.The system can also emit echo data and/or display from spy
The echo data of head is for checking.Image display in system is coupled to image processor, and includes fetus suitable for display
The ultrasonoscopy of heart.Pattern generator in system responds the user's control of the ROI in identification ultrasonoscopy.Example
Such as, using ROI icons ROI can be identified near the tire bud or heart of fetus in ultrasonoscopy.User control in system is also
Suitable for initiating to generate and the associated spatially different M-mode line of area-of-interest.In one example, user can be passed through
Manipulation graphic icons identify ROI in ultrasonoscopy, and can be different from ROI relatively display space M-mode line (example
Such as, M-mode line position between two to 50).The system repeatedly is adopted from some or all of spatially different M-mode lines
Collect echo data (for example, M-mode and/or B-mode echo-signal).Echo data is systematically analyzed or emits, to be analyzed,
With identification whether fetal heart beat can be being identified from the M-mode image that at least one of M-mode line position acquires.It is corresponding
In each space difference M-mode line some in the echo data of time domain acquisition, one or can not present without any one
Go out to indicate the echo-signal of fetal heart beat.Furthermore it is possible to based on being measured in the echo data of the M-mode line of record fetal heart beat
Fetal heart frequency collected echo data is ranked up.In some embodiments it is possible to identify the heartbeat and/or the heart of mother
The substituted or supplemented fetal heart beat of rate.
With reference to figure 1, the ultrasonic system 10 of principle construction according to the present invention is shown in block diagram form.The ultrasonic system
It is configured by two subsystems, that is, front-end collection subsystem 10A and display subsystem 10B.Ultrasonic probe is coupled to acquisition
System comprising two-dimensional matrix array transducer 70 and micro- Beam shaper 72.Also linear or curve pattern transducing can be used
Device.In some embodiments, the only one plane of matrix array will be used for M-mode or B-mode image acquisition.Micro- beam is formed
Device includes circuit, and the circuit control is applied to the signal of 70 element group of array energy transducer (" pack ") and to by every set of pieces
The echo-signal of reception performs some processing.Micro- beam formation in probe desirably reduces electric between probe and ultrasonic system
Number of conductors in cable, for example, in United States Patent (USP) US 5997479 (Savord et al.) and United States Patent (USP) US 6436048
(Pesque) micro- beam is described in be formed, and is herein incorporated into each patent herein by reference.
Probe is coupled to the acquisition subsystem 10A of ultrasonic system.Acquisition subsystem includes that beam forms controller 74, is penetrated
Beam forms controller 74 and is responded to user control 36 and provide control signal, instruction probe transmitting to micro- Beam shaper 72
Timing, frequency, direction and the focusing of beam.Beam forms controller 74 by it to modulus (A/D) converter 18 and beam shape
20 control of growing up to be a useful person is formed to control the beam of the echo-signal received by acquisition subsystem.The echo-signal quilt received by probe
Preamplifier and TGC (time gain control) circuit 16 amplification in acquisition subsystem, then by A/D converter 18 into line number
Word.Then by Beam shaper 20, digitized echo-signal can be formed the beam for guiding and focusing completely.It returns
Wave signal is handled by signal processor 22, and the signal processor executes digital filtering, and can also execute other letters
Number processing, such as, harmonic wave separation, speckle reduce and other desired picture signals processing.
The echo-signal generated by acquisition subsystem 10A is coupled to display subsystem 10B, display subsystem 10B processing
Echo-signal in desired picture format to show.Echo-signal is handled by image line processor 24, described image line
Processor can carry out echo-signal to sample or the echo of given beam is assembled into complete line signal.For M-mode figure
As acquisition, at least one of line signal exported from image line processor 24 can be directed to M-mode processor 30.M moulds
Formula processor generates M-mode image, and the M-mode image is stored in video memory 28 and is shown in display 38
On.B-mode image is acquired, by scan converter 26, desired figure is scan-converted into for the image line of 2D images
As format, as it is known in the art, scan converter 26 executes R- θ transformation.2D images are stored in video memory 28, and
And it is displayed on display 38.
In some embodiments, the 2D image datas from scan converter are output to M-mode synthesizer 40, the M
Mode synthesizer can generate M-mode image according to 2D image datas.As further discussed below, the echo from B-mode line
Signal can be synthesized to generate echo data associated with M-mode line interested.The M synthesized according to B-mode echo-signal
Mode image is further output to video memory 28 and is shown.The figure to be shown together with image can also be utilized
The image being superimposed in memory, which generated by the pattern generator 34 responded to user control 36.Figure is sent out
Raw device 34 is also communicated with M-mode processor 30 and/or M-mode synthesizer 40 so that the picture position of associated M lines be directed to
Normal and/or synthesis the M-mode echo data of corresponding M lines is related.Heart rate synthesizer 34 also with M-mode processor 30 and/
Or M-mode synthesizer 40 communicates, with to normal and/or synthesis M-mode echo data application algorithm, for example, image analysis with/
Or frequency analysis algorithm, to calculate fetal heart frequency.Heart rate analysis device 34 also can according in echo data heartbeat there may be
And M-mode echo data is ranked up.
Normal and/or synthesis M-mode echo data can be stored in video memory 28, for access in future or energy
It is enough that it is shown in real time.It can be deposited using the cineloop (cine loop) of B-mode image previously acquired to store
The echo data of storage can carry out it by using the M-mode echo data of synthesis processing and calculate heart rate later.In real time at
During picture, motion compensation can be applied to track the mass motion of fetus.For example, being described in United States Patent (USP) US 6589176
The patent is incorporated herein by quoting by motion compensation herein.
Can design system for 1D, 2D and/or 3D ultrasonic imaging.In certain embodiments, 2D imaging can by with
In realization for the high frame rate of Image Acquisition.It can be recorded from fetal heart beat using tens to hundreds of frames frame rate per second
Echo-signal.If be imaged using real-time volume, display subsystem 10B includes 3D rendering rendering processor 32, and 3D rendering is painted
Processor processed receives image line from image line processor 24, for drawing real time 3-D image.3D rendering can be in display 38
On be displayed as live (real-time) 3D rendering or be coupled to video memory 28, for storing 3D data sets, for returning later
It cares for and diagnoses.
Fig. 2 is the flow chart for the workflow 76 for showing embodiments of the present invention.The workflow 76 starts from receiving
The step 78 of the image of heart of fetus.In one embodiment, the one or more image of fetal rhythm can be during scanning process
It is collected, and when scanning fetus, Sonographer can identify ROI as described herein.In another embodiment, sound spectrum
Instrument operator can acquire several ultrasonoscopys including tire bud and/or heart of fetus, and the ultrasonoscopy can be by storage (example
Such as, in cineloop) and checked after the scanning.After the scanning, Sonographer can be based on the image of collection
Identify ROI.
In step 80, the ROI in ultrasonoscopy is identified.In some embodiments, echo-signal quilt discrete on the time
Position in the anatomical structure of acquisition can be arranged to default image position, the picture centre that is shown during such as scanning or
In image in acquired image playback.Alternatively, described in following article combination Fig. 4, can be passed through in control system by user
User control control, specify the position in shown or acquisition image.For example, user can manipulate control stick, tracking
Other of ball or user control control indicate icon to position ROI on the area-of-interest in the image comprising heart of fetus.
In certain embodiments, as described below, the ROI in image, the ROI icons energy are identified by ROI icons on a display screen
It is enough to be positioned completely or partially in tire bud and/or heart of fetus near or over.A variety of ROI icons can be used.For example, ROI
Icon can be square, round, ellipse or rectangular shape.ROI icons can also be that simple point, X or cross-hair refer to
Show symbol.In some embodiments it is possible to identify ROI by positioning cursor of mouse above the ROI of image.
In step 82, it generates and the associated multiple spatially different M-mode lines of area-of-interest.M can be generated
Mode line is simultaneously visualized or they can be sightless over the display, only shows ROI icons in the display.
M-mode line is relatively generated with ROI icons, and side is spatially distributed M-mode line on the region of interest by various modes.
For example, if using circle ROI icons, M-mode line can be positioned as the line across circular diameter.It is alternatively possible to scheme in ROI
Addressable Parallel line pattern or cross-hatched pattern in mark, such as round or square.In general, M-mode line pattern (for example, random,
Radial, parallel, cross-hatched and/or honeycomb pattern) it can be used for the ROI icons of any shape or type.Preferably, by this
The M-mode line of the system automatically generated spatial distribution of invention.It can also be drawn by user and be referred to the relevant lines of ROI icons
Show and generates spatially different M-mode lines.The M-mode line that the system can also select certain amount of space different is made
With.In some embodiments, spatially the quantity of different M-mode lines is between 2 to 100, between 5 to 50, between 10 to 50,
Or the range between 10 to 40.
The workflow further includes step 84, i.e. acquisition and the spatially different associated echo data of M-mode line.?
In some embodiments, can during scanning process, by M-mode Image Acquisition, from it is associated with ROI it is multiple spatially not
Same M-mode line acquires echo data repeatedly.Alternatively, echo data can include the echo letter acquired from B-mode image
Number.Herein, M-mode synthesizer is believed by combining the echo from the B-mode image line intersected with given M-mode line position
Number, synthesize echo data for selected M-mode line.It can be carried out in real time during scanning associated with the M-mode line selected
Echo data synthesis, described in following article combination Fig. 5.Similar procedure can be used in synthesizing returning from multiple B-mode images
Wave number evidence, the multiple B-mode image are stored and are analyzed later.
In step 86, the echo data of analysis M line images is to identify fetal heart beat and/or measure the associated fetus heart
Rate.As described below, the technology for doing so includes by analyzing for the time domain number of echoes for being positioned the M lines through heart of fetus
According to detecting the movement of heart of fetus.As shown in step 88, which can optionally include sequence step, the step
The echo data of prioritization record, to identify fetal heart frequency according to some or all of spatially different M-mode line.
The method for executing the present invention using ultrasonic system described herein.The ultrasonic system can operate for execute with
Under any step：Reception includes the ultrasonoscopy of tire bud or heart；Area-of-interest (ROI) is identified in ultrasonoscopy；It generates
From the associated multiple spatially different M-mode lines of area-of-interest；Acquisition corresponds to time of spatially different M-mode line
Wave number evidence；And analysis echo data is to identify and at least one of the spatially different M-mode line associated fetus heart
It fights.
As described herein, generate M-mode line and for detecting the movement of heart of fetus, to identify heart of fetus and/
Or measure fetal heart frequency.Fig. 3 is illustrated in the case where M lines are located through heart of fetus, is examined for using M-mode to be imaged
Survey the technology of movement.It is generated by the M lines for being positioned to extend through the left ventricle (LV) of heart of fetus specifically, Fig. 3 is shown
M-mode image 46.When being positioned in this way, M lines pass through LV's by by the myocardial wall 12 of the side of heart of fetus
Chamber, and pass through the cardiac muscular tissue of the heart other side 14.Along this M lines direction periodical launch ultrasonic beam by LV,
And the A lines received from each transmitting are abreast shown with roll mode with the A lines of previous receipt over the display.The result is that figure
M-mode image shown in 3, wherein as shown in arrow 42, in cardiac cycle, heart of fetus loosens at end diastole point
When, the opposite side of the chambers of the heart separates maximum.As shown in arrow 44, in stage peak contraction phase of cardiac cycle, the opposite wall of the chambers of the heart
It is closest.When Fig. 3 illustrates heart of fetus with each heart contraction and expansion, the periodicity pattern of heart wall motion.By with
The position (movement) that track heart wall 12 or 14 changes, can generate the waveform with phase with cardiac cycle HC.For example, successive by measuring
The peak to peak (or paddy to paddy) of wave periodically, further measures the waveform to determine heart rate.
Fig. 4 illustrates the ultrasound display generated according to one embodiment of present invention.As shown, in ultrasonoscopy 48
In ROI identified by ROI icons 50, ROI icons have been located in above heart of fetus, as shown in ultrasonoscopy 48.Quilt
The spatially different M-mode lines for being identified as M-mode line A, B, C and D are arranged in ROI icons 50.In this example, radial
Ground arranges M-mode line with across the diameter of circle ROI icons, ROI icons are positioned above heart of fetus.Such as the further institutes of this paper
It states, acquires and analyze the echo data corresponding to M-mode line A, B, C and D, to identify fetal heart beat and measure fetal heart frequency.?
Here, for example, panel A' shows that the echo data for M-mode line A has recorded the fetal heart frequency of 158 beatings per minute,
And panel B' shows that the echo data for M-mode line B has recorded the fetal heart frequency of 161 beatings per minute.Panel C'
It is shown with D', M-mode line C and D do not record fetal heart frequency.Image in panel A' and B' includes being remembered according to M-mode Image Acquisition
The expression of the movement of the heart of fetus of record.
In order to measure heart rate, the M-mode in analysis panel A' and B' is shown to obtain pulse movement.In M-mode scanning
Waveform indicates the movement of the heart of fetus of beating, as shown in Figure 3.As shown in panel A' and B', white measure line can by with
Time between measuring the individual heart period.In one example, by pressing the pause button in system, user can make
Measure the heart of fetus period with clamp function, wherein pattern generator 34 is displayed in white measurement line, with measure individual heartbeat it
Between time.This can be completed by measuring the peak to peaks (or paddy to paddy) that two fluctuate in succession.Using heart rate analysis device 34,
Software, which calculates, to be schemed by handling the data from M-mode processor 30 and/or M-mode synthesizer 40 or being come from by access
As the data of memory 28, the measurement result of the duration of cardiac cycle HC is transformed into the fetal heart frequency of calculating.
In embodiments of the present invention, Sonographer uses B-mode imaging real time inspection heart of fetus and mother
Uterus.In some embodiments, B-mode image can be stored in cineloop for analyzing a little later, to determine the fetus heart
Rate.Sonographer can simultaneously or separately generate measures fetal heart beat using M-mode and/or B-mode image acquisition
Required echo data.Fig. 5 is illustrated using the curved linear array energy converter 70' with 128 scan lines to mother uterus
The embodiment that heart of fetus 92 in 94 (fetus is not shown) is imaged and is analyzed.Transducer scans for B-mode image
Region cross scan line 128 from scan line 1, scan line 64 is placed in the middle.Preferably, B moulds are repeated in 128 scan lines
Formula Image Acquisition generates realtime graphic, is used to position ROI icons 90 around heart of fetus 92 for Sonographer.Across
The M-mode line of round ROI icons corresponds to the beam from array energy transducer, raw in the case where being guided with and without beam
At the beam.As shown, beamline 1', 64' and 128', which be used to generate, corresponds to M-mode associated with ROI icons
Three M-mode images in line.Use the horizontal M-mode of B-mode echo-signal synthesis generated during B-mode image acquires
Line 96.As shown in the bracket in Fig. 5, the beam of scan line 50' to the 76' from array energy transducer is used for from along horizontal M
The position of line 96 generates echo-signal, to generate the M-mode image of synthesis.
M-mode Image Acquisition can be executed with various sequences and B-mode image acquires, it is (normal to generate M-mode image
Or synthesis) and B-mode image, carry out real time imagery for Sonographer.As shown, along beam 1', 64' and 128'
M-mode image echo-signal is acquired, to generate the associated echo data of M-mode line corresponding on display.Next
The echo-signal for synthesizing horizontal M lines is collected by scanning beam 50'-76'.Acquire the echo-signal from beam 1-3
And used in generating B-mode image, to be shown to Sonographer.This sequence that can carry out data acquisition, until
128 scan line B-mode images are generated, during this period, from M line positions, with the M line scan rate more much higher than B-mode frame rate
Multi collect echo data.Then the process is repeated.Also alternative sequence can be used.For example, can be in the first part of scanning
Middle acquisition B-mode image, the next complete echo data collected for beam 1', 64' and 128', then acquisition are directed to beam
The B-mode echo-signal of the synthesis of 50'-76'.
According to the positioning of the M-mode line in ROI, at least one of imaging line may extend through the left heart of heart of fetus
Room (LV).When being positioned in this way, imaging beam (being in this example 64') will be across the heart of the side of heart of fetus
Flesh wall passes through the chamber of LV, and across the cardiac muscular tissue of the other side of heart.In M-mode Image Acquisition, the result is that Fig. 4
M-mode image shown in panel A' and B', wherein the opposite side of the chambers of the heart utmostly separates, and is able to record here with every
Secondary heartbeat heart of fetus shrinks the periodicity pattern with heart wall motion when diastole.
Fig. 6 A and 6B, which are illustrated, collects the another of the echo data for corresponding to M-mode line associated with the ROI of ultrasonoscopy
One embodiment.Curved linear array energy converter 70' is associated with the associated M-mode lines of the ROI in ultrasonoscopy for collecting
Echo-signal.As shown in Figure 6A, the ROI figures for 92 top of heart of fetus that lattice is used to be located in mother uterus 94
Mark 90.M-mode line in lattice correspond to propagated in parallel by the M-mode of the ROI in image be imaged beam 60', 63',
66' and 69'.The echo-signal generated by beam 57'-72' can be used to acquire returning corresponding to horizontal M-mode line h1-h5
For the sake of clarity beam is not shown in Fig. 6 A in wave number evidence.As shown in Figure 6B, it acquires along beam 57'-72' in particular point in time
Echo-signal and for for horizontal M-mode line h1-h5 synthesize M-mode image.As shown in the stain in Fig. 6 B, the time 1,
Time 2, time 3, time 4 and time 5, along echo of the beam acquisitions along beam 57'-72' for generating horizontal M-mode line
Signal.Furthermore it is possible to collect the acquisition of data using various sequences.Herein, first along beam 60', 63', 66' and
69' acquires echo-signal, is shown for four kinds of normal M-modes.Then echo-signal is collected from beam 57'-72', for synthesizing
The M-mode image of horizontal M lines.Can along beam with three be interval (for example, be directed to scan line 1,2 and 3, followed by 4,5 and 6
Deng) collect for carrying out the echo-signal that B-mode image is shown to Sonographer.Alternative sequence can be used.For example, can
It is next complete to collect the M moulds for being directed to beam 60', 63', 66' and 69' to acquire B-mode image in the first part of scanning
Formula image, then acquisition are directed to the B-mode echo-signal of the synthesis of beam 57'-72'.
Claims (14)
1. a kind of ultrasonic diagnosis imaging system of fetal heart beat for identification, the system comprises：
Ultrasonic probe comprising array energy transducer；
Image processor is suitable for echo data of the processing from probe to be shown；
Image display is coupled to described image processor and includes the ultrasonoscopy of heart of fetus suitable for display；
Pattern generator, to identifying that the user's control of area-of-interest (ROI) responds in the ultrasonoscopy；And
User control, is suitable for initiating generating and the associated multiple spatially different M-mode lines of the area-of-interest,
Wherein, the imaging system is suitable for：(1) acquisition corresponds to the echo data of the spatially different M-mode line；And
(2) echo data is analyzed to identify and at least one of the spatially different M-mode line associated tire
Youngster's heartbeat, and
Wherein, the system is suitable for returning to what is acquired based on the fetal heart frequency measured for each of corresponding M-mode line
Wave number evidence is ranked up.
2. system according to claim 1, wherein the system is further adapted for according to corresponding to the described of the M-mode line
Echo data measures fetal heart frequency.
3. system according to claim 1, wherein spatially different at least some of the M-mode line is by institute
State system automatically generated.
4. system according to claim 1, wherein spatially different at least some of the M-mode line is by institute
It states system and generation is indicated according to user.
5. system according to claim 1, wherein the system is suitable for acquiring using M-mode or B-mode image acquisition
Corresponding to the echo data of at least some of the spatially different M-mode line.
6. system according to claim 1, wherein the system is suitable for producing come the freely array energy transducer by combining
The echo-signal of the raw multiple B-mode image lines intersected from given M-mode line corresponds to the spatially different M to synthesize
The echo data of at least some of mode line.
7. a kind of method using ultrasonic imaging to identify fetal heart beat, the method includes：
Reception includes the ultrasonoscopy of heart of fetus；
Identify the area-of-interest (ROI) in the ultrasonoscopy；
It generates and the associated multiple spatially different M-mode lines of the area-of-interest；
Acquisition corresponds to the echo data of the spatially different M-mode line；
The echo data is analyzed, to identify and at least one of the spatially different M-mode line associated fetus
Heartbeat, and
Based on the fetal heart frequency measured for corresponding spatially different each of M-mode line, to the number of echoes acquired
According to being ranked up.
8. according to the method described in claim 7, including based on corresponding at least one in the spatially different M-mode line
A echo data determines fetal heart frequency.
9. according to the method described in claim 7, wherein, the spatially different M-mode line is automatic by computer system
Generate, by the computer system according to user indicate generate or be a combination thereof.
10. according to the method described in claim 7, wherein, it includes using M-mode or B-mode image to acquire the echo data
Acquisition.
11. according to the method described in claim 7, wherein, the reception includes receiving several B-modes stored in cineloop
Ultrasonoscopy, and the acquisition includes echo data of the synthesis from several B-mode ultrasonoscopys.
12. a kind of computer system of fetal heart beat for identification, the computer system includes enabling the system when executed
The instruction that system proceeds as follows：
Reception includes the ultrasonoscopy of heart of fetus；
Identify the area-of-interest (ROI) in the ultrasonoscopy；
It generates and the associated multiple spatially different M-mode lines of the area-of-interest；
Acquisition corresponds to the echo data of the spatially different M-mode line；And
The echo data is analyzed, to identify and at least one of the spatially different M-mode line associated fetus
Heartbeat, and
Based on the fetal heart frequency measured for corresponding spatially different each of M-mode line come to the number of echoes acquired
According to being ranked up.
13. computer system according to claim 12 further includes that the system is enabled to be based on corresponding to institute when executed
The echo data of at least one of spatially different M-mode line is stated to determine the instruction of fetal heart frequency.
14. computer system according to claim 12, wherein the reception includes receiving to store in cineloop
Several B-mode ultrasonoscopys, and the acquisition includes echo data of the synthesis from several B-mode ultrasonoscopys.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361886694P | 2013-10-04 | 2013-10-04 | |
| US61/886,694 | 2013-10-04 | ||
| PCT/IB2014/064575 WO2015049609A1 (en) | 2013-10-04 | 2014-09-17 | Ultrasound systems and methods for automated fetal heartbeat identification |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105592799A CN105592799A (en) | 2016-05-18 |
| CN105592799B true CN105592799B (en) | 2018-11-06 |
Family
ID=51752154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480054509.2A Active CN105592799B (en) | 2013-10-04 | 2014-09-17 | Ultrasonic system and method for automating heartbeat identification |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9993224B2 (en) |
| EP (1) | EP3052023B1 (en) |
| JP (1) | JP6420326B2 (en) |
| CN (1) | CN105592799B (en) |
| WO (1) | WO2015049609A1 (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10682118B2 (en) * | 2015-10-30 | 2020-06-16 | General Electric Company | Ultrasound system and method for analyzing cardiac periodicity |
| US10265052B2 (en) * | 2016-05-10 | 2019-04-23 | Samsung Medison Co., Ltd. | Method of displaying ultrasound image and ultrasound diagnosis apparatus |
| US20180042578A1 (en) * | 2016-08-12 | 2018-02-15 | Carestream Health, Inc. | Automated ultrasound image measurement system and method |
| US10595826B2 (en) * | 2016-12-01 | 2020-03-24 | Siemens Medical Solutions Usa, Inc. | Heart rate assistance for phase determination in echocardiography |
| EP3366221A1 (en) * | 2017-02-28 | 2018-08-29 | Koninklijke Philips N.V. | An intelligent ultrasound system |
| US10646196B2 (en) | 2017-05-16 | 2020-05-12 | Clarius Mobile Health Corp. | Systems and methods for determining a heart rate of an imaged heart in an ultrasound image feed |
| US11717257B2 (en) * | 2018-01-22 | 2023-08-08 | General Electric Company | Fetal ultrasound monitoring method and system |
| US20210015375A1 (en) * | 2018-03-29 | 2021-01-21 | University Of Ulsan Foundation For Industry Cooperation | Method and apparatus for monitoring fetal heart rate |
| CN112512436B (en) * | 2018-07-27 | 2024-03-08 | 皇家飞利浦有限公司 | Apparatus, system and method for pulmonary beat detection in ultrasound |
| CN111374708B (en) * | 2018-12-28 | 2024-02-20 | 深圳迈瑞生物医疗电子股份有限公司 | Fetal heart rate detection method, ultrasonic imaging device and storage medium |
| US11727558B2 (en) * | 2019-04-03 | 2023-08-15 | Bfly Operations, Inc. | Methods and apparatuses for collection and visualization of ultrasound data |
| KR20220111251A (en) * | 2019-09-27 | 2022-08-09 | 비에프엘와이 오퍼레이션즈, 인크. | Methods and devices for monitoring fetal heartbeat and uterine contraction signals |
| KR20210112807A (en) | 2020-03-06 | 2021-09-15 | 삼성메디슨 주식회사 | Ultrasound image apparatus and method for controlling thereof |
| EP4029453A1 (en) * | 2021-01-13 | 2022-07-20 | Koninklijke Philips N.V. | An apparatus for monitoring a heartbeat of a fetus |
| WO2022246314A1 (en) * | 2021-05-21 | 2022-11-24 | The General Hospital Corporation | Methods and systems for conversion of one data type to another |
| EP4108178A1 (en) * | 2021-06-24 | 2022-12-28 | Koninklijke Philips N.V. | Generation of m-mode data for detecting fetal cardiac activity |
| WO2022268844A1 (en) | 2021-06-24 | 2022-12-29 | Koninklijke Philips N.V. | Generation of m-mode data for detecting fetal cardiac activity |
| US20230263501A1 (en) * | 2022-02-23 | 2023-08-24 | EchoNous, Inc. | Determining heart rate based on a sequence of ultrasound images |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19531419A1 (en) * | 1994-08-30 | 1996-03-07 | Vingmed Sound As | Ultrasonic image display of a moving organ |
| CN1725981A (en) * | 2002-12-18 | 2006-01-25 | 皇家飞利浦电子股份有限公司 | Ultrasonic doppler system for determining movement of artery walls |
| EP1967867A2 (en) * | 2007-03-08 | 2008-09-10 | Medison Co., Ltd. | Ultrasound system and method of forming ultrasound images |
| JP2010193945A (en) * | 2009-02-23 | 2010-09-09 | Toshiba Corp | Ultrasonic diagnostic apparatus |
| CN101889876A (en) * | 2010-08-23 | 2010-11-24 | 秦皇岛市康泰医学系统有限公司 | Fetal heart rate detection method based on PC |
| WO2011158136A1 (en) * | 2010-06-17 | 2011-12-22 | Koninklijke Philips Electronics N.V. | Automated heart rate detection for 3d ultrasonic fetal imaging |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3894586B2 (en) * | 1994-08-30 | 2007-03-22 | ビングメッド サウンド アクチスカベット | Method for generating anatomical M-mode display, ultrasound imaging device and method of using ultrasound imaging device |
| US5997479A (en) | 1998-05-28 | 1999-12-07 | Hewlett-Packard Company | Phased array acoustic systems with intra-group processors |
| US6468216B1 (en) | 2000-08-24 | 2002-10-22 | Kininklijke Philips Electronics N.V. | Ultrasonic diagnostic imaging of the coronary arteries |
| US6582367B1 (en) * | 2000-09-15 | 2003-06-24 | Koninklijke Philips Electronics N.V. | 2D ultrasonic transducer array for two dimensional and three dimensional imaging |
| US6589176B2 (en) | 2001-12-05 | 2003-07-08 | Koninklijke Philips Electronics N.V. | Ultrasonic image stabilization system and method |
| JP4276595B2 (en) * | 2004-08-18 | 2009-06-10 | アロカ株式会社 | Ultrasonic diagnostic equipment |
| CN100581482C (en) * | 2005-01-31 | 2010-01-20 | 皇家飞利浦电子股份有限公司 | Method and system for deriving a heart rate without the use of an electrocardiogram in non-3d imaging applications |
| EP1731102A1 (en) * | 2005-06-08 | 2006-12-13 | Esaote S.p.A. | Method for measuring and displaying time varying events |
| US7486074B2 (en) * | 2006-04-25 | 2009-02-03 | The Board Of Trustees Of The Leland Stanford Junior University | Self-calibration methods for parallel imaging and multipoint water-fat separation methods |
| US8396531B2 (en) * | 2007-03-27 | 2013-03-12 | Siemens Medical Solutions Usa, Inc. | System and method for quasi-real-time ventricular measurements from M-mode echocardiogram |
| WO2009067740A1 (en) * | 2007-11-28 | 2009-06-04 | Signostics Pty Ltd | Multi-modal medical scanning method and apparatus |
| US20100185088A1 (en) * | 2009-01-21 | 2010-07-22 | Christian Perrey | Method and system for generating m-mode images from ultrasonic data |
| JP5596940B2 (en) * | 2009-06-30 | 2014-09-24 | 株式会社東芝 | Ultrasonic diagnostic equipment |
| KR101121289B1 (en) | 2009-08-25 | 2012-03-23 | 삼성메디슨 주식회사 | Ultrasound system and method for setting image optimization parameters |
| CN103037773B (en) * | 2010-07-30 | 2016-08-24 | 皇家飞利浦电子股份有限公司 | The display of individual biplane image and output |
| US9179892B2 (en) * | 2010-11-08 | 2015-11-10 | General Electric Company | System and method for ultrasound imaging |
| US8715184B2 (en) * | 2010-12-16 | 2014-05-06 | Siemens Medical Solutions Usa, Inc. | Path parametric visualization in medical diagnostic ultrasound |
| WO2015026787A2 (en) * | 2013-08-19 | 2015-02-26 | University Of Utah Research Foundation | Ultrasound apparatus, system, and method |
| WO2016026532A1 (en) * | 2014-08-21 | 2016-02-25 | Irdeto B.V. | User authentication using a randomized keypad over a drm secured video path |
-
2014
- 2014-09-17 EP EP14786541.4A patent/EP3052023B1/en active Active
- 2014-09-17 WO PCT/IB2014/064575 patent/WO2015049609A1/en active Application Filing
- 2014-09-17 US US15/027,050 patent/US9993224B2/en active Active
- 2014-09-17 CN CN201480054509.2A patent/CN105592799B/en active Active
- 2014-09-17 JP JP2016517559A patent/JP6420326B2/en active Active
-
2018
- 2018-05-29 US US15/991,188 patent/US10448921B2/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19531419A1 (en) * | 1994-08-30 | 1996-03-07 | Vingmed Sound As | Ultrasonic image display of a moving organ |
| CN1725981A (en) * | 2002-12-18 | 2006-01-25 | 皇家飞利浦电子股份有限公司 | Ultrasonic doppler system for determining movement of artery walls |
| EP1967867A2 (en) * | 2007-03-08 | 2008-09-10 | Medison Co., Ltd. | Ultrasound system and method of forming ultrasound images |
| JP2010193945A (en) * | 2009-02-23 | 2010-09-09 | Toshiba Corp | Ultrasonic diagnostic apparatus |
| WO2011158136A1 (en) * | 2010-06-17 | 2011-12-22 | Koninklijke Philips Electronics N.V. | Automated heart rate detection for 3d ultrasonic fetal imaging |
| CN102946810A (en) * | 2010-06-17 | 2013-02-27 | 皇家飞利浦电子股份有限公司 | Automated heart rate detection for 3d ultrasonic fetal imaging |
| CN101889876A (en) * | 2010-08-23 | 2010-11-24 | 秦皇岛市康泰医学系统有限公司 | Fetal heart rate detection method based on PC |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6420326B2 (en) | 2018-11-07 |
| JP2016531622A (en) | 2016-10-13 |
| US10448921B2 (en) | 2019-10-22 |
| US9993224B2 (en) | 2018-06-12 |
| EP3052023A1 (en) | 2016-08-10 |
| WO2015049609A1 (en) | 2015-04-09 |
| CN105592799A (en) | 2016-05-18 |
| US20160242732A1 (en) | 2016-08-25 |
| EP3052023B1 (en) | 2019-11-13 |
| US20180271476A1 (en) | 2018-09-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105592799B (en) | Ultrasonic system and method for automating heartbeat identification | |
| JP4699724B2 (en) | Method and apparatus for obtaining a volumetric scan on a periodically moving object | |
| JP5715123B2 (en) | Ultrasound diagnostic imaging system and method using three-dimensional fetal heart imaging method with non-ECG biological synchronization collection | |
| EP2437666B1 (en) | Method and apparatus for measuring heart contractility | |
| US8565504B2 (en) | Ultrasonic image processing apparatus and ultrasonic image processing method | |
| JP5858783B2 (en) | High frame rate quantitative Doppler flow imaging using unfocused transmit beams | |
| JP4805140B2 (en) | System for generating ultrasound images using line-based image reconstruction | |
| US7871379B2 (en) | Ultrasonic diagnostic apparatus and method of ultrasonic measurement | |
| US9451930B2 (en) | Ultrasonic diagnosis apparatus, ultrasonic image processing apparatus, and recording medium on which ultrasonic image processing program is recorded | |
| JP5889886B2 (en) | Automatic heart rate detection for 3D ultrasound fetal imaging | |
| US20140108053A1 (en) | Medical image processing apparatus, a medical image processing method, and ultrasonic diagnosis apparatus | |
| JP2007525299A (en) | System and method for ECG-triggered retrospective color flow ultrasound imaging | |
| JPH10127638A (en) | Signal processing method for object including moving part, and echo graphic device executing the method | |
| US8323198B2 (en) | Spatial and temporal alignment for volume rendering in medical diagnostic ultrasound | |
| CN107072635A (en) | The quality metric for the multi-hop echocardiogram collection fed back for intermediate user | |
| JPH11327A (en) | Ultrasonograph | |
| JP2008167975A (en) | Ultrasonic diagnostic equipment, heart rate synchronization signal generator and heart rate synchronization signal generation method | |
| US11877893B2 (en) | Providing a three dimensional ultrasound image | |
| WO2009031078A1 (en) | Spectral and color doppler imaging system and method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |