CN1055668A

CN1055668A - The injection pen of dose indicating

Info

Publication number: CN1055668A
Application number: CN 91102207
Authority: CN
Inventors: 戴尔·C·哈里斯
Original assignee: Eli Lilly and Co
Current assignee: Eli Lilly and Co
Priority date: 1990-04-04
Filing date: 1991-04-03
Publication date: 1991-10-30
Anticipated expiration: 2006-04-03
Also published as: CN1056539C

Abstract

A kind of two embodiment of syringe of multiple dose include the structure of the selected injection of indication liquid measure.Being connected respectively to injector housing becomes the energy relative motion with indicating graduation with first member of plunger rod with second member designs, include an exterior section that has the dosage indicating graduation on it one of in first and second member, first and second member include a window round another of described exterior section, only some can see by window dosage indicating graduation on this exterior section, and this part of seeing illustrates selected liquid infusion amount.

Description

The injection pen of dose indicating

The present invention relates to be applicable to the device of from a container, allotting the quantitative liquid material, be particularly related to a kind of hypodermic syringe, the specific material that is used to provide fixed quantity injection such as insulin or people's generation hormone of this syringe with pen or propelling pencil outward appearance.

The patient of diabetes and other disease often finds can not find the health professional and helps and carry out subcutaneous or the quantitative liquid preparation of intramuscular injection.In this case, these patients just need a kind of do not need the health professional help to realize to allot required accurate dosage, syringe cheaply.This class patient usually needs every day and surpasses a drug, and each consumption may be slightly different.Measurer with outward appearance of pen or propelling pencil is known.This measurer generally is even as big as holding several dosage but little of putting in the pocket easily or in the parcel.This device is disclosed in United States Patent (USP) 4,413, in 760,4,498,904 and 4,592,745, also is disclosed in addition among the international open file WO 87/02895 of PCT and the WO 88/07874, and in the european patent application 89101509.1.

In this class device, be typically provided with a liquid container, this container has a design and pierces through so that the liquid in the container can be from wherein flowing out first end with the sealing of carrying out subcutaneous or intramuscular injection to a needle assembly.Second end of container is closed by a plunger usually.In order to prevent that others from monkeying or re-using these liquid containers, common way is that to become to make a thrust can apply thereon plunger design long-pending but be not provided with and be applicable to the appearance liquid long-pending device of tractive plunger to increase container with the appearance liquid that reduces container.

Long element with plunger rod character is accommodated in the housing to apply a power to the plunger of second end that is sealing container.Be provided with a device in order to the distance of measurement column stopper rod motion to determine to cause volume reduction amount that liquid in container is allotted, liquid container.Generally recognize all that thereby measurer should have some and only allow plunger rod to prevent that towards the unidirectional motion of plunger effect that any meeting causes the liquid container volume to increase is applied to the device on the plunger rod part.Being typically provided with a safety head is enclosed within on the needle assembly on the blind end that is connected to container.

Though the pen-type injector of prior art has obtained some successes, also find to have some shortcomings.In some prior art injection pen, in a single day injected dose is just adjusted can not turn down a smaller numerical value exactly.This has unnecessary waste with regard to causing the medicinal liquid in the syringe.In some prior art injection pen, the dosage indication is difficult to read.The prior art injection pen requires the patient to read two scale values usually and does some and calculate, and could determine the dosage of being executed.In addition, many prior art devices are generally realized the repeated use character that it is specific by replacing container, and this just makes syringe can use the material of non-doctor's advice not according to standard ground.

In order to overcome these and other the shortcoming of prior art, the syringe of design includes an injector housing, a needle assembly and the plunger that can move and discharge by syringe needle from housing with liquid that is connected on the injector housing far-end in housing according to the present invention.Be provided with a plunger rod with non-circular cross sections, it has a far-end and contacts with plunger to apply a power on plunger.The inner surface of injector housing includes one and rotates with respect to housing to prevent plunger rod roughly corresponding to the non-circular openings of plunger rod cross section, and is provided with the plunger rod surface engagement to prevent the device of plunger rod towards the direction motion of leaving needle assembly.

One first member and one second member are connected respectively on injector housing and the plunger rod, and are designed to the energy relative motion with indicating graduation.Include an exterior section that has a dosage indicating graduation on it one of in first and second member.In first and second member another includes round this exterior section and has the device of a window, only some can see by window dosage indicating graduation on this exterior section, and this part of seeing intactly and is clearly indicated selected liquid infusion amount.Therefore, use the injection pen of the design according to the present invention, the patient only needs the scale in the readout window just can determine dosage to be injected.Do not need to determine dosage according to a plurality of scales or calculating.

Oblatio two the explanation specific embodiments of the present invention.In one embodiment, can regulate selectively to change required dosage by the sleeve that is threaded onto on the injector housing for one.Being located at labelling on the sleeve, that occur with dosage indicating graduation form is covered by a block that is fixed on the plunger rod.A window on the block only allows a part of scale be seen, visible part shows selected dosage.In this embodiment of the present invention, the length overall of injection pen is along with liquid is allotted and shortened from syringe again and again.

In second example embodiment, a sleeve is pivotally connected on the injector housing, but cannot longitudinally regulate with respect to injector housing.Can regulate selectively to change required dosage by the hollow block that is threaded onto on the plunger rod for one.Be located at labelling on the block, that occur with dosage indicating graduation form and covered by sleeve, have only a window to allow a part of scale be seen on sleeve, visible part shows selected dosage.In this embodiment of the present invention, the length overall of injection pen still remains basically unchanged after repeatedly using.

In two embodiment, window can include a magnifier and amplify graduated image.In addition, two embodiment are provided with a facility that scale can be returned to zero before selected adjusting the by required dosage.This device generally speaking can be made with cheap material, and is suitable for assembling with machinery, directly facilitates a very low manufacturing cost, thereby makes these devices can become the device of disposable.Dose titration can upwards increase and reduce downwards, thereby has reduced the waste of medicinal liquid.Importantly, the dosage indication can be read simply with directly, thereby makes the medicinal liquid of allotting from this device obtain more accurate and more economical use.

Its its feature and advantage, to illustrating the detailed description of preferred embodiment that is found at present, realize optimised form of the present invention, the one skilled in the art will be very clear by following.These detailed descriptions are specifically to carry out in conjunction with the accompanying drawings.

Fig. 1 is the front view of the first embodiment of the present invention.

Fig. 2 is a cross sectional detail that get along the 2-2 line of Fig. 1, that part disconnects, that amplify.

Fig. 3 is the central cross-sectional view of getting by the 3-3 line of Fig. 2.

Fig. 4 is the plan view that is used in the dosage indicating graduation among first embodiment.

Fig. 5 is the front view that the part of the second embodiment of the present invention disconnects.

Fig. 6 is the cross sectional detail of getting along the 6-6 line of Fig. 5.

Fig. 7 is a left end view embodiment illustrated in fig. 5, and sleeve has rotated with respect to block.

Fig. 8 is the cutaway view of getting by the 8-8 line of Fig. 6.

Fig. 9 is the cutaway view of getting by the 9-9 line of Fig. 6.

Figure 10 is the plan view of the pushing packing ring seen from the right side of Fig. 6.

Figure 11 is the plan view that is used in the dosage indicating graduation in the second embodiment of the invention.

Figure 12 is the cutaway view of the magnifier in the window of the arbitrary embodiment of the present invention of packing into.

Syringe 20 shown in Figure 1 is designed to the general appearance that includes pocket clip 22 and have a pen or propelling pencil.This syringe 20 includes an injector housing 24, and the container 26 of a carrying liquid is housed in it.Needle assembly 28 is connected on the far-end 30 of housing 24 and includes a demountable over cap 32.Being provided with one, to illustrate at Fig. 1 be transparent cover medicated cap 34, and this cover medicated cap is sealed injector housing 24, needle assembly 28 and over cap 32.

The near-end 36 of cover medicated cap 34 is connected with the far-end 38 of sleeve 40.Sleeve 40 is one with clip 22 shown in figure 2.Sleeve 40 includes an interior threaded surface 42, and this internal coiling surface 42 engages with the near-end 44 of injector housing 24, thereby make between injector housing 24 and the sleeve 40 relative motion can be arranged.Plunger 46 is positioned at container 26, so that the liquid of splendid attire is discharged by syringe needle 48.

Plunger rod 50 has a far-end, and these far-end 52 contact plungers 46 are to apply a power of allotting liquid thereon.Plunger rod 50 illustrates with cross section in Fig. 3, has a non-circular external configuration.Cutting ferrule 54 is fixed in the injector housing 24 one fixedly on the position of rotation and include the inner surface of its configuration with the outer surface coupling of plunger rod 50, produces relative rotation between plunger rod 50 and the injector housing 24 preventing.Pushing packing ring 56 be clamped between cutting ferrule 54 and the container 26 and with the surface combination of plunger rod, as shown in Figure 3, to prevent that plunger rod 50 is towards the direction motion of leaving needle assembly 28.This has just guaranteed that plunger rod 50 can only be towards the direction motion that liquid is discharged from container 26.

The near-end 58 of plunger rod 50 includes an all-in-one-piece block 60 with it.This block has a container 62.Container 62 is arranged on member 64 tops, and member 64 has a labelling as shown in Figure 4, that constitute dosage indicating graduation 66 on its outer surface.Member 64 is with sleeve 40 frictional engagement and total moving with respect to block 60 with sleeve 40.

When in operation, syringe 20 is initial as shown in fig. 1.In order from syringe 20, to allot the liquid of an aequum, cover medicated cap 34 will be unloaded from syringe towards the right-hand of Fig. 1, press the direction rotational sleeve 40 of arrow A then, thereby make sleeve 40 axially towards moving right.Along with sleeve 40 rotates and moves axially with respect to injector housing 24, block 60 is followed the interaction of injector housing near-end 44 by interior threaded surface 42 and is rotated effectively and move axially in the position shown in the left end dotted line to the greatest extent towards Fig. 2 by the direction of arrow B.

Along with this displacement takes place, that part of of dosage indicating graduation 66 that can see by container 62 changes, and the digital linear shown in Fig. 4 increases, and demonstrates the liquid dosages of allotting and increases.Therefore, required dosage can be selected by seeing through container 62 observation dosage indicating graduations.It is also noted that sleeve 40 can freely rotate on both direction, therefore,, can adjust up and down again if required dose value is transferred unintentionally when excessive in regulating course of action.

In case required dose value is chosen, over cap 32 just can take off from needle assembly 28, and syringe needle just is in the state that the liquid that is ready to be contained in the container 26 carries out subcutaneous or intramuscular injection.In case syringe needle 48 is suitably in place, can be afterburning on block 60 termination, make block, all-in-one-piece plunger rod 50 and plunger 46 are done linear mobilely towards the right with it, liquid is allotted from container 26.The batching displacement of plunger rod 50 by block a shot 60 and member 64 between recline the contact and stopped.

When required amount of liquid is allotted from syringe 20, over cap 32 is removed and put again to syringe needle 48 from injection position, also will cover medicated cap 34 subsequently and recover.At last, member 64 is rotated with respect to sleeve 40, up to till " 0 " scale occurring on the window 62.It is also noted that after syringe 20 used each time, in all further retraction sleeve 40 of injector housing 24, this just gave rough indication directly perceived of user of using a kind of like this pen of preparing burden, demonstrates the amount of liquid that also retains in the syringe roughly.

In second preferred embodiment, Fig. 5 with and under view shown in syringe of the present invention 70 include pocket clip 72 and have the general appearance of a pen or propelling pencil.In syringe 70, pocket clip 72 constitutes a part of cover medicated cap 74, and cover medicated cap 74 is enclosed within on the injector housing 76 slidably.Injector housing 76 includes a liquid container 78, and the liquid in it is allotted by the syringe needle 80 of needle assembly 82, and needle assembly includes an over cap 84 that is analogous to the over cap 32 of syringe 20.Container 78 includes a plunger 86, and this plunger makes when mobile liquid in the container 78 discharge by syringe needle 80 towards the right of Fig. 6.

Plunger rod 88 has a far-end 90 that contacts with plunger 86.This plunger rod 88 includes a spiral outer surface 92, and this spiral outer surface is cut off by a pair of cannelure that is clearly shown that in Fig. 8 and 9 94 and 96.Injector housing 76 includes the fingers that inwardly stretch out 98 and 100 of pair of engaging in

groove

94 and 96, rotates with respect to injector housing 76 to prevent plunger rod 88.A pushing packing ring 102 as shown in figure 10, is clamped between the near-end of the distal surface of fingers 98,100 and container 78.The hock that inwardly stretches out 104 on the pushing packing ring stretches in

groove

94 and 96, contacts with the bottom of each groove to prevent that plunger rod 88 is towards the direction motion of leaving needle assembly 82.

A hollow block 106 is being sealed plunger rod 88, and engages with the helical surface 92 of plunger rod 88 by the female thread portion 108 near block 106 far-end.Block 106 includes a zigzag part 110, thereby this part produces the vibration that can feel out with the fingers that stretches out 112 interactions of injector housing 76 when block 106 rotates with respect to injector housing 76.The outside part 114 of block has labelling as shown in figure 11, that constitute dosage indicating graduation 116.

Sleeve 118 is contained on the injector housing 76 by pawl portion 120 and can rotates with respect to housing 76.This sleeve is sealed the whole block except extension 122.Window 124 on the sleeve 118 can intuitively be observed the qualifying part of the scale 116 of band on block 106 outsides 114.Block 106 and sleeve 118 include a

surface texture labelling

126 and 128 respectively, so that sleeve 118 is with respect to block 106 zeroings.

In operation, use user that syringe 70 injects an a selected amount of liquid at first sleeve 118 to be turned to the position of, as shown in Figure 5 two zero graduations 124 appreciable with respect to injector housing 76 by window.Sleeve and block are designed so that the zeroing of scale 116 aims at as illustrated in fig. 5 and automatically finish by sleeve 118 is turned to

surface texture labelling

126 and 128 with respect to injector housing 76.

106 the extension 122 of then will blocking a shot rotates with respect to injector housing 76.Such rotation of block 106 makes block up walk along the screw thread 92 of plunger rod 88, by this axially to left side motion, as illustrated in Figures 5 and 6.Block 106 rotation also make scale 116 pass through window 124 appreciable that part of, change the increase of scale numeral as first embodiment.Block 106 rotations with respect to injector housing 76 also make the pass by groove of serrated surface 110 of fingers 112, the motion that causes fingers to have perceiving.By setting the size of these grooves suitably, the groove number that fingers 112 is passed by can follow the scale that can see by window 124 to be complementary.The perceptible motion of flexible fingers 112 follows the initial zeroing that is realized by surface texture labelling 126 and 128 mutual alignings to connect, and makes vision have the people of impairment can both use this syringe 70.

When in window 124, being transferred to the scale of required dosage value, cover medicated cap 74 can be taken off from syringe 70.Over cap 84 also can take off from syringe needle 80, and syringe needle is correctly placed, and prepares injection.Along with on the end of block 106, exerting pressure, block is axially moved together towards needle assembly 82 with plunger rod.The motion of plunger rod impels plunger 86 that liquid is discharged by syringe needle 80 from liquid container 78.Block 106 and plunger rod 88 move through block 106 and injector housing 76 on backstop 130 places recline and stop.In block such axially-movable of 106, the fingers 112 that stretches out slides a single groove 110 in, and having limited thus blocks a shot 106 does any meeting and cause selecting dosage changes, rotatablely moving with respect to injector housing 76.

After selected dosage has been injected, syringe needle 80 is removed and over cap 84 is enclosed within on as shown in Figure 6 the position again from its injection position.Return along with also covering cap sleeve.Except selected injection volume was 20,40 or 60 scale units, the relative position between block 106 and the sleeve 118 was not mutual aligned position, but the position of always diverging to mutually as shown in Figure 7.Can turn to zero-bit with respect to injector housing 76 as previously mentioned this moment with sleeve 118, makes syringe 70 be in the next SBR of selecting the liquid of metering of injection.

Figure 12 illustrates the window of above-mentioned arbitrary embodiment with the form of cross section, and this window includes a magnifier 132, and its effect is the image that amplifies the dosage indicating graduation.Be used for regulating the flexible fingers 112 that produces realizable motion at syringe graduation though only include in second embodiment, this feature can be used in the syringe 20.Although the present invention combines the preferred embodiment of two examples and is described in detail, other variation exists within the scope of the present invention and spirit of describing in claims and limiting with improvement.

Claims

1, a kind of syringe that injecting fluid is housed, it includes the device of regulating the injection liquid measure selectively and the device of indicating selected liquid measure, it is characterized in that this syringe also includes:

Injector housing, one can be moved in housing and be had with plunger and contact plunger rod with first end that applies a power on plunger with one with plunger that liquid is discharged;

Be connected respectively on injector housing and the plunger rod and be designed to can relative motion with one first member and one second member of indicating graduation, include an exterior section that has a dosage indicating graduation on it one of in first member and second member, in first member and second member another includes round this exterior section and has the device of a window, only some can see by window dosage indicating graduation on this exterior section, and this part of seeing illustrates selected liquid infusion amount.

2,, it is characterized in that it also includes in injector housing, to be used for preventing the anti-rotation device that plunger rod rotates with respect to injector housing by the syringe of claim 1.

3, press the syringe of claim 2, it is characterized in that described anti-rotation device includes an inner surface of injector housing, this inner surface has one roughly corresponding to the non-cylindrical opening of the cross section of plunger rod, rotates with respect to injector housing to prevent plunger rod.

4, by the syringe of claim 1, it is characterized in that it also include one on the far-end that is connected to injector housing needle assembly and with the surface engagement of plunger rod to prevent the anti-locking apparatus of plunger rod towards the direction motion of leaving needle assembly.

5,, it is characterized in that it also includes round stop device plunger rod, that stop second member to move towards the needle assembly direction when liquid measure is selected in injection by the syringe of claim 4.

6, by the syringe of claim 4, it is characterized in that it also includes a liquid container that is located in the injector housing, described anti-locking apparatus is contacting the near-end of liquid container this container is remained on the fixed position with respect to injector housing.

7, by the syringe of claim 2, it is characterized in that in injection housing, also include surface engagement with plunger rod to prevent the anti-locking apparatus of plunger rod in order to prevent anti-rotation device that plunger rod rotates with respect to injector housing towards the direction motion of leaving injector tip.

8, press the syringe of claim 1, it is characterized in that first member includes one and includes the sleeve that this sleeve is joined movably to the device on the injector housing, described window also includes a magnifier in order to the image of the visible part on the amplification dosage indicating graduation.

9, by the syringe of claim 8, it is characterized in that second member includes a block that is connected on the plunger rod, this block includes described window and magnifier, can see described dosage indicating graduation by them.

10, press the syringe of claim 8, it is characterized in that in including second member that is connected to the block on the plunger rod, block comprises described dosage indicating graduation on the block exterior section, and only some can be seen by described window and magnifier on described sleeve to measure indicating graduation this quarter.

11, a kind of syringe that injecting fluid is housed, it includes the device of regulating the injection liquid measure selectively and the device of indicating selected liquid measure, it is characterized in that this syringe also includes:

One includes one and is connected on the injector housing sleeve being made the sleeve with respect to the threaded joints of the adjustment movement of injector housing, and this sleeve includes an exterior section that has the dosage indicating graduation on it;

A hollow block that is fixed on the plunger rod, an exterior section of block covers this telescopic exterior section and has a window, only some can see by this window dosage indicating graduation on telescopic this part, and this part of seeing illustrates selected liquid infusion amount.

12, a kind of syringe that injecting fluid is housed, it includes the device of regulating the injection liquid measure selectively and the device of indicating selected liquid measure, it is characterized in that this syringe also includes:

Injector housing, one can be moved in injector housing and be had with plunger and contact plunger rod with first end that applies a power on plunger with one with plunger that liquid is discharged;

Sealing including of plunger rod for one and making block make device, having the dosage indicating graduation of indication block on the exterior section of this block with respect to the adjustment movement of plunger rod with respect to the adjustment movement of plunger rod with the hollow block of the first end second opposed end; With

One round the far-end of hollow block and be rotatably connected to the sleeve of injector housing, this sleeve includes a window, only some can see by this window dosage indicating graduation on telescopic this part, and this part of seeing illustrates selected liquid infusion amount.

13, a kind of syringe that injecting fluid is housed, it includes the device of regulating the injection liquid measure selectively and the device of indicating selected liquid measure, it is characterized in that this syringe also includes:

An injector housing, a needle assembly that is connected to the far-end of this injector housing, the plunger that can in housing, move and discharge by syringe needle from housing with liquid, one has non-circular cross sections and contacts plunger rod with the far-end that applies a power on plunger with one with plunger, one has one roughly corresponding to the injection housing inner surface of non-circular openings to prevent that plunger rod from rotating with respect to housing of the cross section of plunger rod, with the device of surface engagement to prevent that plunger rod from moving towards the direction of leaving needle assembly with plunger rod;

Be connected respectively on injector housing and the plunger rod and be designed to can relative motion with first member and second member of indicating graduation, include an exterior section that has the dosage indicating graduation on it one of in first member and second member, in first member and second member another includes round this exterior section and has the device of a window, only some can see by window dosage indicating graduation on this exterior section, and this part of seeing illustrates selected liquid infusion amount.