CN105566162A - Rilpivirine midbody preparing technology - Google Patents

Rilpivirine midbody preparing technology Download PDF

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Publication number
CN105566162A
CN105566162A CN201610097412.0A CN201610097412A CN105566162A CN 105566162 A CN105566162 A CN 105566162A CN 201610097412 A CN201610097412 A CN 201610097412A CN 105566162 A CN105566162 A CN 105566162A
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vinyl cyanide
amino
preparation technology
cis
bromo
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CN105566162B (en
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俞菊荣
顾志锋
孙光明
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SUZHOU LAKESTAR PHARMA TECH Co Ltd
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SUZHOU LAKESTAR PHARMA TECH Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The invention belongs to the field of medicinal chemistry, and particularly relates to a rilpivirine midbody preparing technology. The technology comprises the steps that 1, 4-bromo-2,6-dimethylaniline and acrylonitrile react under the catalysis of palladium acetate and phosphine ligands to generate 3-(4-amino-3,5-dimethyl phenyl) acrylonitrile (trans-form:cis-form=5:1); 2, the cis-trans mixture is crystallized and purified in hydrochloric acid isopropanol to generate (E)-3-(4-amino-3,5-dimethyl phenyl) acrylonitrile salt. Based on the prior art, raw materials are easy to obtain, cost is low, operation is easy, and the requirement of industrial production is met.

Description

The preparation technology of rilpivirine intermediate
Technical field:
The invention belongs to medicinal chemistry art, being specifically related to a kind of is the preparation technology that starting raw material synthesizes rilpivirine intermediate with bromo-2, the 6-xylidines of 4-.
Background technology:
Rilpivirine, English name is Rilpivirine, chemistry 4-[[4-[[4-[(E)-2-cyanoethenyl]-2 by name, 6-dimethyl-phenyl] amino] pyrimidin-2-yl] amino] benzonitrile, be by Tibotec drugmaker of the U.S. research and develop novel non-nucleoside reverse transcriptase inhibitor (non-nucleosidereversetran-scriptaseinhibitor, NNRTI), go on the market in May, 2011 in the U.S., trade(brand)name Edurant.Features such as there is easy synthesis, antiviral activity is strong, oral administration biaavailability is high, security is good.
About rilpivirine intermediate (E)-3-(4-amino-3,5-3,5-dimethylphenyl) synthesis of vinyl cyanide hydrochloride, Org.Process.Res.Dev2008, the synthetic method of 530-536, namely with 4-iodo-2,6-xylidine is that starting raw material and vinyl cyanide generate 3-(4-amino-3 in palladium carbon (5%mol) catalysis, 5-3,5-dimethylphenyl) vinyl cyanide (trans: cis=4 ~ 5:1), with N, N-N,N-DIMETHYLACETAMIDE is solvent, temperature of reaction 130-140 DEG C; Because temperature of reaction is high, process produces a large amount of tar, causes a lot of difficulty to the recovery of palladium carbon and aftertreatment.
Summary of the invention:
In order to overcome that above-mentioned processing condition are harsh, catalyzer cost is high and the defect such as aftertreatment trouble, the present invention aim to provide a kind of simple to operate, good product quality, cost are low, the preparation technology of the rilpivirine intermediate of being convenient to large-scale production.
In order to realize goal of the invention, the technical solution used in the present invention is: a kind of rilpivirine intermediate (E)-3-(4-amino-3,5-3,5-dimethylphenyl) preparation technology of vinyl cyanide hydrochloride, with 4-bromo-2,6-xylidine is starting raw material, it is characterized in that, comprise the steps:
(1) under the condition of temperature 20 ~ 40 DEG C, 4-bromo-2,6-xylidine and vinyl cyanide and sodium-acetate to be dissolved in solvent and to react 7 ~ 8 hours under palladium and Phosphine ligands L catalysis, obtain 3-(amino-3, the 5-3,5-dimethylphenyls of 4-) vinyl cyanide cis-trans-isomer mixture; Wherein the mol ratio of cis-isomeride and trans-isomer(ide) is 4 ~ 5:1;
(2) 3-(4-amino-3,5-3,5-dimethylphenyl) vinyl cyanide cis-trans-isomer mixture, in hydrochloric acid Virahol, 60-65 DEG C is stirred after 16 hours, be cooled to 10-15 DEG C, filtration obtains (E)-3-(amino-3, the 5-3,5-dimethylphenyls of 4-) vinyl cyanide hydrochloride; Reaction formula is:
Described phosphorus ligand L structural formula is
In step (1), the molecular fraction that palladium and Phosphine ligands L account for the mixture (be namely corresponding molar percentage with the percentage ratio that palladium and Phosphine ligands L obtain divided by the total mole number of the mixture of above 5 kinds of materials) of bromo-2, the 6-xylidines of 4-and vinyl cyanide, sodium-acetate, palladium and Phosphine ligands L is respectively respectively 0.1 ~ 0.5% and 0.2 ~ 1.0%.The mol ratio of described vinyl cyanide and bromo-2, the 6-xylidines of 4-is 1.1:1.0 ~ 1.5:1.0.The mol ratio of described sodium-acetate and bromo-2, the 6-xylidines of 4-is 1.2:1.0 ~ 2.0:1.0.Solvent for use is acetonitrile, THF or Isosorbide-5-Nitrae-dioxane.Preferably, in step (1), the temperature of reaction of vinyl cyanide and bromo-2, the 6-xylidines of 4-is 20 ~ 30 DEG C.
The mol ratio of 3-(amino-3, the 5-3,5-dimethylphenyls of 4-) vinyl cyanide cis-trans-isomer mixture and hydrochloric acid Virahol is 1.5:1.0 ~ 6.0:1.0.
The present invention with palladium (0.1-0.5mol%) and Phosphine ligands L (0.2-1mol%) for catalyst system, under the condition of temperature 20 ~ 40 DEG C, 4-bromo-2,6-xylidine and vinyl cyanide and sodium-acetate react 3 ~ 6 hours in THF, obtain 3-(amino-3, the 5-3,5-dimethylphenyls of 4-) vinyl cyanide (trans: cis=4 ~ 5:1); 3-(4-amino-3,5-3,5-dimethylphenyl) vinyl cyanide cis-trans-isomer mixture, in hydrochloric acid Virahol, 60-65 DEG C was stirred after 16 hours, was cooled to 10-15 DEG C, filtration obtains (E)-3-(amino-3, the 5-3,5-dimethylphenyls of 4-) vinyl cyanide hydrochloride.This technique solves processing condition harshness, and the difficulty such as high and aftertreatment trouble of catalyzer cost, avoids the protection of other patents simultaneously, have the advantages such as simple to operate, good product quality, cost are low, be convenient to large-scale production.
Embodiment
Below in conjunction with specific embodiment, the present invention is further described.
Embodiment one:
(compound 2synthesis)
The 20L four-hole bottle of thermometer, mechanical stirring, constant pressure funnel and device for absorbing tail gas is housed, nitrogen replacement three times, adds THF (10L), palladium (5.6g, 0.5%mol) and Phosphine ligands L (28g, 1%mol), 20 ~ 30 DEG C are stirred 1 hour.Add sodium-acetate (1.02Kg, 7.5mol), bromo-2, the 6-xylidines (1.0Kg, 5mol) of 4-and vinyl cyanide (405g, 7.5mol) successively.20 ~ 30 DEG C are continued stirring reaction 4 hours, and then add water (5.0L), stratification, separates organic phase, and the aqueous phase tertiary ether of first (5L) extracts once.Merge organic phase, obtain 3-(amino-3, the 5-3,5-dimethylphenyls of 4-) vinyl cyanide crude product 870g (trans: cis=4.6:1) after concentrating under reduced pressure, crude yield 102%.
(compound 3synthesis)
In the 20L four-hole bottle that thermometer, mechanical stirring, constant pressure funnel and device for absorbing tail gas are housed, add 3-(4-amino-3,5-3,5-dimethylphenyl) vinyl cyanide crude product 870g (800g) and ethanol (6L), stirring is warming up to 50 ~ 60 DEG C, slow dropping hydrochloric acid Virahol (600g, 30%wt), in dropping process, control temperature is lower than 70 DEG C.After dropwising, continue to stir 12 hours at 50 ~ 60 DEG C.Be cooled to 10-20 DEG C, filter, Virahol (each 1L) washes twice, and 40-50 DEG C of vacuum-drying obtains product (880g), two step yields 85%, purity 98%.(cis isomerism body burden 1.0%)
API-MS(m/z):209[M+1] -。
1hNMR (solvent DMSO-d6; Interior mark TMS): δ 2.31 (s, 6H), δ 6.30 (d, 1H), δ 7.35 (s, 2H), δ 7.48 (d, 1H), δ 9.12 (brs, 3H).
Embodiment two:
(compound 2synthesis)
The 20L four-hole bottle of thermometer, mechanical stirring, constant pressure funnel and device for absorbing tail gas is housed, nitrogen replacement three times, adds THF (10L), palladium (1.2g, 0.1%mol) and Phosphine ligands L (6g, 0.2%mol), 20 ~ 30 DEG C are stirred 1 hour.Add sodium-acetate (1.02Kg, 7.5mol), bromo-2, the 6-xylidines (1.0Kg, 5mol) of 4-and vinyl cyanide (405g, 7.5mol) successively.20 ~ 30 DEG C are continued stirring reaction 4 hours, and then add water (5.0L), stratification, separates organic phase, and the aqueous phase tertiary ether of first (5L) extracts once.Merge organic phase, obtain 3-(amino-3, the 5-3,5-dimethylphenyls of 4-) vinyl cyanide crude product 870g (trans: cis=4.7:1) after concentrating under reduced pressure, crude yield 102%.
(compound 3synthesis)
In the 20L four-hole bottle that thermometer, mechanical stirring, constant pressure funnel and device for absorbing tail gas are housed, add 3-(4-amino-3,5-3,5-dimethylphenyl) vinyl cyanide crude product 870g (800g) and ethanol (6L), stirring is warming up to 65 DEG C, slow dropping hydrochloric acid Virahol (600g, 30%wt), in dropping process, control temperature is lower than 70 DEG C.After dropwising, continue to stir 12 hours at 65 DEG C.Be cooled to 10-20 DEG C, filter, Virahol (each 1L) washes twice, and 40-50 DEG C of vacuum-drying obtains product (880g), two step yields 85%, purity 98%.(cis isomerism body burden 1.1%)
Embodiment three:
(compound 2synthesis)
The 20L four-hole bottle of thermometer, mechanical stirring, constant pressure funnel and device for absorbing tail gas is housed, nitrogen replacement three times, adds THF (10L), palladium (5.6g, 0.5%mol) and Phosphine ligands L (28g, 1%mol), 20 ~ 30 DEG C are stirred 1 hour.Add sodium-acetate (1.02Kg, 7.5mol), bromo-2, the 6-xylidines (1.0Kg, 5mol) of 4-and vinyl cyanide (405g, 7.5mol) successively.20 ~ 30 DEG C are continued stirring reaction 4 hours, and then add water (5.0L), stratification, separates organic phase, and the aqueous phase tertiary ether of first (5L) extracts once.Merge organic phase, obtain 3-(amino-3, the 5-3,5-dimethylphenyls of 4-) vinyl cyanide crude product 870g (trans: cis=4.6:1) after concentrating under reduced pressure, crude yield 102%.
(compound 3synthesis)
In the 20L four-hole bottle that thermometer, mechanical stirring, constant pressure funnel and device for absorbing tail gas are housed, add 3-(4-amino-3,5-3,5-dimethylphenyl) vinyl cyanide crude product 870g (800g) and ethanol (6L), stirring is warming up to 50 ~ 60 DEG C, slow dropping hydrochloric acid Virahol (300g), in dropping process, control temperature is lower than 70 DEG C.After dropwising, continue to stir 12 hours at 60 DEG C.Be cooled to 10-20 DEG C, filter, Virahol (each 1L) washes twice, and 40-50 DEG C of vacuum-drying obtains product (880g), two step yields 85%, purity 98%.(cis isomerism body burden 0.9%)
More than show and describe ultimate principle of the present invention, principal character and advantage.The technician of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and specification sheets just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.

Claims (8)

1. the preparation technology of rilpivirine intermediate (E)-3-(amino-3, the 5-3,5-dimethylphenyls of a 4-) vinyl cyanide hydrochloride, with bromo-2, the 6-xylidines of 4-for starting raw material, is characterized in that, comprise the steps:
(1) under the condition of temperature 20 ~ 40 DEG C, 4-bromo-2,6-xylidine and vinyl cyanide and sodium-acetate to be dissolved in solvent and to react 7 ~ 8 hours under palladium and Phosphine ligands L catalysis, obtain 3-(amino-3, the 5-3,5-dimethylphenyls of 4-) vinyl cyanide cis-trans-isomer mixture; Wherein the mol ratio of cis-isomeride and trans-isomer(ide) is 4 ~ 5:1;
(2) 3-(4-amino-3,5-3,5-dimethylphenyl) vinyl cyanide cis-trans-isomer mixture, in hydrochloric acid Virahol, 50-65 DEG C is stirred after 16 hours, be cooled to 10-15 DEG C, filtration obtains (E)-3-(amino-3, the 5-3,5-dimethylphenyls of 4-) vinyl cyanide hydrochloride; Reaction formula is:
2. preparation technology according to claim 1, is characterized in that described phosphorus ligand L structural formula is
3. preparation technology according to claim 1, is characterized in that, in the reaction system of step (1), the molecular fraction of palladium and Phosphine ligands L is respectively 0.1 ~ 0.5% and 0.2 ~ 1.0%.
4. preparation technology according to claim 1, is characterized in that, the mol ratio of described vinyl cyanide and bromo-2, the 6-xylidines of 4-is 1.1:1.0 ~ 1.5:1.0.
5. preparation technology according to claim 1, is characterized in that, the mol ratio of described sodium-acetate and bromo-2, the 6-xylidines of 4-is 1.2:1.0 ~ 2.0:1.0.
6. preparation technology according to claim 1, is characterized in that, solvent for use is acetonitrile, THF or Isosorbide-5-Nitrae-dioxane, volume 5-15L.
7. preparation technology according to claim 1, is characterized in that, in step (1), the temperature of reaction of vinyl cyanide and bromo-2, the 6-xylidines of 4-is 20 ~ 30 DEG C.
8. preparation technology according to claim 1, is characterized in that, the mol ratio of 3-(amino-3, the 5-3,5-dimethylphenyls of 4-) vinyl cyanide cis-trans-isomer mixture and hydrochloric acid Virahol is 1.5:1.0 ~ 6.0:1.0.
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106008366A (en) * 2016-05-25 2016-10-12 山东大学 Preparation method of rilpivirine
CN106187916A (en) * 2016-07-04 2016-12-07 宜昌人福药业有限责任公司 A kind of method of effective removal rilpivirine isomer
CN111333543A (en) * 2020-04-17 2020-06-26 武汉工程大学 Synthesis method of rilpivirine intermediate
US11166952B2 (en) 2019-11-29 2021-11-09 Aptorum Therapeutics Limited Composition including rilpivirine and method for treating tumors or cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102815920A (en) * 2012-08-01 2012-12-12 浙江捷丰环保技术工程有限公司 Method for producing brick by sintering dried sludge, building waste soil and building rubbish

Patent Citations (1)

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CN102815920A (en) * 2012-08-01 2012-12-12 浙江捷丰环保技术工程有限公司 Method for producing brick by sintering dried sludge, building waste soil and building rubbish

Non-Patent Citations (1)

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Title
DANIEL WEILIANG TAY ET AL.: ""Palladium-meta-Terarylphosphine Catalyst for the Mizoroki-Heck Reaction of (Hetero)Aryl Bromides and Functional Olefins", 《THE JOURNAL OF ORGANIC CHEMISTRY》 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106008366A (en) * 2016-05-25 2016-10-12 山东大学 Preparation method of rilpivirine
CN106187916A (en) * 2016-07-04 2016-12-07 宜昌人福药业有限责任公司 A kind of method of effective removal rilpivirine isomer
US11166952B2 (en) 2019-11-29 2021-11-09 Aptorum Therapeutics Limited Composition including rilpivirine and method for treating tumors or cancer
US11571422B2 (en) 2019-11-29 2023-02-07 Scipio Life Sciences Limited Composition including rilpivirine and method for treating tumors or cancer
US12023334B2 (en) 2019-11-29 2024-07-02 Aptorum Therapeutics Limited Composition including rilpivirine and method for treating tumors or cancer
CN111333543A (en) * 2020-04-17 2020-06-26 武汉工程大学 Synthesis method of rilpivirine intermediate
CN111333543B (en) * 2020-04-17 2022-09-16 武汉工程大学 Synthesis method of rilpivirine intermediate

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