CN105561473B - A kind of self-closing disease acupoint stimulation therapeutic equipment based on biofeedback technology - Google Patents
A kind of self-closing disease acupoint stimulation therapeutic equipment based on biofeedback technology Download PDFInfo
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- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
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- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
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Abstract
The invention discloses a kind of self-closing disease acupoint stimulation therapeutic equipment based on biofeedback technology, including signal acquiring system and signal transacting and output system, the signal acquiring system includes signal input system, eye electrical activity gathering system；Signal transacting and output system include signal acquisition screening system, electric acupuncture apparatus and acupoint stimulation system.The present invention is used for the clinical treatment to autism children, hospital can be used in, office, or personal family, the invention reside in the treatment means for expanding Acupuncture Clinical, modern biomedical current research technology will be based on first and means are incorporated into traditional acupuncture treatment clinic, realize the optimum integration of the two, the present invention not only applies the treatment in self-closing disease, it is all after also contains to treat traditional acupuncture (i.e. without output regulation, without time effect, traditional acupoint stimulation of inanimate object feedback regulation modulation) utilize all invention thinkings of biofeedback technology development acupuncture and moxibustion therapy.
Description
Technical field
The invention belongs to field of biomedicine technology, more particularly to a kind of self-closing disease acupuncture point thorn based on biofeedback technology
Swash therapeutic equipment.
Background technology
Traditional medicine thinks that " god " and " essence ", " gas " three are the basic substance of human body altogether, and " god " be by " essence " and
" gas " gives birth to the concentrated expression for functional activity, is the overall reflection of biological phenomena.Wherein essence, gas belong to material, the refreshing function of dominant.
It is existing in outer various performances that its content includes the advanced functional activity such as consciousness, thinking, spirit and thought and complexion, pulse condition etc..
The famous acupuncture doctor Yang Shangshan of Sui-Tang bines exists《Huangdi Neijing Taisu, Grand Simplicity of Inner Canon of Huangdi》Mentioned in " be intended to for pin person, must first control god ", therefore
There is close ties with traditional acupuncture clinical treatment for the external manifestation and observation regulation and control of " god ".It there is no definitely yet with " god "
Characterize and lack objective quantizating index, there is no the correlative study for going deep into system so far.
《It is interior through Ling Shu Miraculous Pivot or Divine Axis》In mention " all arteries and veins persons come under mesh ... the network of the twelve regular channels 365, its vim and vigour all on
Note and walk sky key in face, walk mesh on its vivid YANG QI and be eyeball " illustrate that all arteries and veins enter mesh, the built-in qi-blood-body fluid of mesh and outgoing is
" god ", therefore Jin Dynasty Liu Wansu exists《Etiology based on plain questions》In mention the Shenhua of the five internal organs " mesh be ".Therefore, in ancient books, ancients
The visual angle unique from its give we provided new Research Thinking ----from eye movement feature analyze " god " external manifestation,
So as to excavate the quantizating index that it is available for analysis.
Meanwhile pop psychology research shows, vision system is that the mankind obtain the most important passage of external information, is being tested
Psychologic early history Psychology Memory man is begun to notice eye movement characteristics and its psychological significance of rule, and skill is moved using eye
Art (eye movement technique), which explores Information procession mechanism of the people under various different conditions, also turns into present age psychology
Learn the important pattern of research.By the research to eye movement characteristics, from eye movement, eye move the time, eye moves direction and distance and pupil
The parameters such as hole size reflect the psychological activity feature of subject, analyze its brain and how to screen or collect information, and this thinking
New technological means is provided without the exterior representations suspected of explanation " god " and the treatment of autism children.
Project research team by " research that acupuncture changqiang influences on FMRX1 knock out mice synaptic plasticity " and
Multinomial problems early stage such as " acupuncture Changqiang acupoint treat the multiple center clinical study of mental retardation " finds autism children expression in the eyes
Lax, mostly without purpose eye movement.And to significantly improve all kinds of children's spirit developmental lag obstacles (including self-closing for acupuncture
Disease) binocular its " god ", clinic can be emerged from by improvement situations such as infant eyeball fixes ability, eye movements.This with《Spirit
Pivot》In it is described：The viewpoints such as " with wanting for pin, refreshing without its is forgotten ", " all thorns are true, must first control god " are consistent.Therefore to self-closing disease
The analysis of children's eyeball motion feature, contribute to the characteristic of activities for reflecting its " god ", judge Clinical Acupuncture curative effect.
Autism of children (ChildrenAutism), also known as autism, nineteen forty-three are reported first by Leo Kanner.Thirdly
Big classical symptom is：Human communication disorders, disfluency, interest is narrow and mechanical stiff behavior.Its cause of disease and morbidity machine
System is not clear, and Recent study thinks, autism is relevant with brain centre structure and neurodevelopment, and complex inheritance, immune, sense
The factors such as dye, organic, environment and psychology.With studied in recent years deeply and raising to the illness degree of concern,
Increasing children are diagnosed as autism of children patient, and epidemiological study shows, the sick incidence of disease is before 40 years
0.4 ‰ are significantly increased to current 6.0~10.0 ‰.Foreign countries have scholar completely to count American-European and Asian countries's autism incidence of disease to obtain
The incidence of disease for going out the disease is 0.7 ‰~1.3 ‰.And there is Case report in China successively since late 1980s, at present still
Epidemiology survey without the national incidence of disease.These children can not exchange with other people in daily life, can't take care of oneself,
Also be present the problems such as feeblemindedness, aphasis in wherein 2/3rds infant, the growth of serious influence infant and all one's life, give
Society and family bring white elephant.At present, treatment of the modern medicine for autism of children is not found a kind of certain yet
Feasible effect method, mainly based on education and training and behaviour modification, and pogoniasis even lifelong.Therefore need badly at present cut it is feasible
Treatment means be used for clinical treatment, with farthest improve infant social adaptation, improve infant quality of life.
With the development of eye movement technique, more and more scholars by record observation eye movement come disclose the consciousness of people,
The advanced functional activity such as psychological activity.Its major way is that the reflective of the cornea that passes through analyzes eye movement situation.Conventional
The dynamic index of eye includes：Watch attentively, twitching of the eyelid, return and regard and pupil diameter.And self-closing disease infant core symptom is：Abnormal social energy
Power, communication capability etc., interest and behavior pattern, therefore vision attention, overall consciousness, the consciousness of motion and reasoning etc. be present in such infant
The defects of in terms of basic cognitive ability.There are some researches show autism children under the visual stimulus of social context, shows as exception
Eye movement mode.Foreign study shows that infant often avoids the eyes of other side in social context, and abstract cartoon picture is seen
It is again similar to normal child's eye movement mode when examining.With more and more being paid close attention to eye movement technique cognitive ability, China also has
Scholar is based on to observing in terms of children cognition, content includes Different Rule geometric figure, difference in eye movement technique aspect
Color image, different mood patterns etc., and the research being related in terms of self-closing disease infant cognition is less, is mainly known by facial expression
Not, the approach such as picture exchange communication is inquired into.Therefore rule and cognition are moved to the visual stimulus of self-closing disease infant difference, eye at present
The correlation of ability is still short of system, in-depth study.
The present invention is on the basis of early-stage Study, eyeball fortune of the analysis autism children under different visual stimulus states
Dynamic rule, analyzes its electrical activity feature, before and after comparison stimulus the eye of subject move rule (including：First blinkpunkt and watch attentively
The distribution of point, time, order) and electric (EOG) potential change of eye, the visual stimulus of specific category is summarized to autism children
The influence characteristic of the dynamic rule of eye and EOG, and then result of study is used in the treatment of self-closing disease patient, for the self-closing disease patient that takes good care of oneself
Its " god " plays certain effect.Simultaneously can be fully using the telecommunications for collecting visual stimulus in the therapeutic intervention of self-closing disease infant
Number feature patient is taken targetedly, autotelic traditional medicine therapeutic intervention.
Risen year by year from the incidence of disease of the world or even Chinese autism children at present, these children in daily life without
Method exchanges with other people, can't take care of oneself, wherein the problems such as feeblemindedness, aphasis also be present in 2/3rds infant,
The growth of serious influence infant and all one's life, white elephant is brought to society and family.At present, modern medicine is for children
A kind of truly feasible effect method is not found in the treatment of self-closing disease yet, mainly based on education and training and behaviour modification, and it is more
Must even lifelong.Therefore need badly at present and cut feasible treatment means and be used for clinical treatment, it is social farthest to improve infant
Adaptability, the quality of life for improving infant.
Self-closing disease (autism)：Childhood autism is a kind of hypotype of pervasive developmental disorders, common with male, onset in
Infantile period, it is mainly shown as that different degrees of speech maldevelopment, Social disorder, interest are narrow and behavior is carved
Plate.3/4 patient be there are about with obvious mental retardation.Invention aims to provide one kind effectively, based on Traditional Chinese Medicine pin
A kind for the treatment of technology of moxibustion technology combination modern biomedical feedback technique, there is provided side for being available for autism children clinical treatment
Method.
Have lot of documents at present and research report confirms that the acupoint stimulation (including scalp acupuncture) of the traditional Chinese medical science has prominent treatment
Effect is longer (more so that " year " calculates), and many infants can not adhere to long-term treatment and delay yet with the acupuncture and moxibustion therapy clinic cycle
Golden hour (0-6 year).The invention provides a kind of self-closing disease that can carry out in family or community medicine place to treat
Instrument, the clinical treatment for vast self-closing disease patient provide new idea and method.
The present invention uses the signal modulating system based on eye electricity biofeedback, is look at object using autism children and has
Electro-ocular signal caused by realizing the exchange activity of purpose, regulates and controls the output of conventional electroacupuncture stimulation signal.In the system, eye telecommunications
Number selection and output, and regulation and control of the output signal to acusector signal.
The wherein output system of acusector is as common acusector, and its input signal is the electro-ocular signal after modulation, by the letter
Number regulation and control electroacupuncture stimulation granting.
The content of the invention
It is an object of the invention to provide a kind of self-closing disease acupoint stimulation therapeutic equipment based on biofeedback technology, it is intended to solves
Certainly speech maldevelopment, Social disorder, the interest of self-closing disease are narrow and behavior is mechanical, and mental retardation is asked
Topic.
The present invention is achieved in that a kind of self-closing disease acupoint stimulation therapeutic equipment based on biofeedback technology, including letter
Number acquisition system and signal transacting and output system, the signal acquiring system includes signal input system, eye electrical activity is searched
Collecting system；The eye electrical activity gathering system includes the input signal circuit after shielding, pre-amplification circuit, right leg drive electricity
Road, rear class amplifying circuit；The signal transacting and output system include signal acquisition screening system, electric acupuncture apparatus and acupoint stimulation
System；The signal acquisition screening system includes eye electricity acquisition module and eye electric treatment module；
The signal input system is connected by signal with the input signal circuit input after shielding, the input after shielding
Signal circuit output end is connected with pre-amplification circuit input；Pre-amplification circuit output end connects with driven-right-leg circuit all the way
Connect, another way is connected with rear class input amplifier, and rear class amplification circuit output end is gathered by the signal of output with eye electricity
Module input connects, and eye electricity acquisition module output end electrically connects with eye electric treatment module input, the output of eye electric treatment module
End is electrically connected with electric acupuncture apparatus input, and electric acupuncture apparatus output end is connected with acupoint stimulation system；
The signal input system includes the AgCl electrodes for being used for gathering electro-ocular signal or common of bipolar lead mode
ECG electrode, the AgCl electrodes are connected with the input signal circuit signal after shielding, and the AgCl electrodes include being used to adopt
Collect two electrodes of HEOL and HEOR, the Vertical Square for gathering vertical electro-ocular signal of the horizontal direction of horizontal channel electro-ocular signal
To two electrodes of VEOL and VEOU, GND reference electrodes；Described two electrodes of HEOL and HEOR are arranged in the left side of subject
At 2.5cm outside right eye exterior angle；Described two electrodes of VEOL and VEOU are arranged in 2cm and bottom right eye on the right eyebrow of subject
At eyelid 2cm, the GND reference electrodes are placed on the forehead of subject；
The acupoint stimulation system includes the acupoint stimulation device positioned at subject acupuncture point and connected by signal and electric acupuncture apparatus
Connect.
Further, the GND reference electrodes of the AgCl electrodes of the collection electro-ocular signal are 1 or 3.
Further, the signal of the input signal circuit reception signal input system input after the shielding, is filled by shielding
Put and signal is shielded；Signal after shielding is connected with instrument amplifier INA333 generating positive and negative voltage input all the way, instrument
Amplifier INA333 generating positive and negative voltage both ends are connected with 510 kilo-ohms of resistance；It is defeated with 1/2 OPA2333 operational amplifiers all the way
Go out end connection and be connected simultaneously with the negative input of 1/2 OPA2333 operational amplifiers, 1/2 OPA2333 operational amplifiers
Output end is connected by a resistance with the negative pole end of the 2nd 1/2 OPA2333 operational amplifiers and the one 390 kilo-ohm of parallel connection
Resistance, the output ends of another 1/2 OPA2333 operational amplifiers is connected by the 2nd 390 kilo-ohm of the resistance of connecting with right leg.
Further, the pre-amplification circuit receives two input signals after shielding, two input signals respectively with C1
With C2 capacitance connections, positive terminal of the C1 and C2 electric capacity output end respectively with OPA2333-A and OPA2333-B is connected, C1 and C2 electricity
The resistance R1 and R2 of 10 megaohms of connection simultaneously between appearance output end；OPA2333-A and OPA2333-B output end respectively with
INA333 the 2nd negative pole and the connection of the 3rd positive terminal, the INA333 external 1.65 volts of voltage of the 5th pin, INA333 the 7th pin
External 3.3 volts of positive voltages, the 1st pin are connected with the 8th pin by 510 kilo-ohms of resistance, OPA233-A and OPA2333-B output
End is connected with 100 kilo-ohms of R29 and R28 simultaneously.
Further, the driven-right-leg circuit receives two input signals of pre-amplification circuit, two input signals point
It is not connected with C1 and C2 capacitance connections, positive terminal of the C1 and C2 electric capacity output end respectively with OPA1 and OPA2, C1 and C2 electric capacity is defeated
Go out between end while connect 10 megaohms of resistance R1 and R2；OPA1 and OPA2 output end respectively with INA333 the 2nd negative pole and
3rd positive terminal connects, the INA333 external 1.65 volts of voltage of the 5th pin, the INA333 external 3.3 volts of positive voltages of the 7th pin, the
1 pin is connected with the 8th pin by 510 kilo-ohms of resistance R3, OPA1 and OPA2 output end be connected with simultaneously 100 kilo-ohms R29 and
R28,100 kilo-ohms of R29 and R28 output ends and OPA3 positive terminal are connected, and OPA3 negative pole ends are exported by polarity line and OPA3
End connection, OPA3 output ends are connected by 20 kilo-ohms of R30 and OPA4 negative pole end, at the same the electric capacity C17 in parallel with OPA4 and
Be connected after 300 kilo-ohms of R32 connections, electric capacity C17 and 300 kilo-ohms of R32 parallel connections with OPA4 output end, OPA4 output end with
Right leg connection, OPA4 positive terminal are parallel with electric capacity C13,40 kilo-ohms of R34,40 kilo-ohms of R33,40 kilo-ohms of R34 and electric capacity
Output head grounding after C13 parallel connections, 40 kilo-ohms of R33 are connected to the volt of voltage -3.3.
Further, the rear class amplifying circuit receives the signal of pre-amplification circuit transmission by the transmission of electric capacity C6 output ends
Positive terminal to OPA1 while 1 megaohm of the R4 in electric capacity C6 output end earths；OPA1 output end connects 31 kilo-ohms
R7 inputs, R7 output ends connect 31 kilo-ohms of R8 inputs while shunt capacitance C12, electric capacity C12 output end output signals；R8
Output end and OPA2 positive terminal connect, and OPA2 output end output signal, R8 output ends connect electric capacity C7 simultaneously, and electric capacity C7 is defeated
Go out end to be grounded all the way, connect 10 kilo-ohms of R9 all the way, R9 output end connects OPA2 negative pole end all the way, connects 15 kilo-ohms all the way
R10 by signal output；Be grounded all the way by connecting 10 kilo-ohms of R5 in OPA1 negative pole end, all the way by 37 kilo-ohms of R6 and
1 kilo-ohm of adjustable resistance R7 of series connection is connected with 31 kilo-ohms of R7 inputs.
Another object of the present invention is to provide a kind of self-closing disease acupoint stimulation therapeutic equipment based on biofeedback technology
Control method, the control method include：
Electro-ocular signal is gathered by signal input system, signal input system passes through for gathering horizontal channel electro-ocular signal
Horizontal direction two electrodes of HEOL and HEOR, the VEOL and VEOU two of vertical direction for gathering vertical electro-ocular signal
Electrode, GND reference electrodes collection autism children are look at eye telecommunications caused by the exchange activity of object and conscious purpose
Number；
Electro-ocular signal is screened by eye electrical activity gathering system, signal acquisition screening system, handled, to discriminating
Not, the electro-ocular signal after handling is transported to electric acupuncture apparatus；
Electric acupuncture apparatus will receive electro-ocular signal and be transferred to acupoint stimulation system；
Acupoint stimulation system instructs according to electric acupuncture apparatus and carries out electronic stimulation to acupuncture point.
Further, it is to be sieved by eye electrical activity gathering system, signal acquisition that the electric acupuncture apparatus, which will receive electro-ocular signal,
Select the signal after system regulation.
A kind of self-closing disease acupoint stimulation therapeutic equipment good effect based on biofeedback technology provided by the invention：The present invention
For the clinical treatment to autism children, hospital, office, public institution, or personal family can be used in.The present invention proposes
A kind of new acupuncture and moxibustion therapy theory, i.e., traditional with acupuncture point and to being folded in the acupuncture and moxibustion therapy means based on the stimulation mode at acupuncture point
Add a kind of active stimulation for being based on modern biotechnology feedback technique (with electricity physiological signal), that is, realize and skill is treated to modern Acupuncture Clinical
The integration of art means, enriching Acupuncture Clinical stimulates means, changes and relied on clinical consulting hours, nothing in Acupuncture Clinical stimulation in the past
The acupuncture stimulating of selectivity, using the associated biomolecule signal (such as electric signal) in patient disease feature, improve the target of acupuncture stimulating
Tropism..
Brief description of the drawings
Fig. 1 is the controlling party of the self-closing disease acupoint stimulation therapeutic equipment provided in an embodiment of the present invention based on biofeedback technology
Method flow chart；
Fig. 2 is that the structure of the self-closing disease acupoint stimulation therapeutic equipment provided in an embodiment of the present invention based on biofeedback technology is shown
It is intended to；
In figure：1st, signal input system；2nd, eye electrical activity gathering system；3rd, signal acquisition screening system；4th, electric acupuncture apparatus；
5 and acupoint stimulation system.
Fig. 3 is the eye telecommunications of the self-closing disease acupoint stimulation therapeutic equipment provided in an embodiment of the present invention based on biofeedback technology
Number gathering system structural representation；
After Fig. 4 is the shielding of the self-closing disease acupoint stimulation therapeutic equipment provided in an embodiment of the present invention based on biofeedback technology
Input signal circuit schematic diagram；
Fig. 5 is the preceding storing of the self-closing disease acupoint stimulation therapeutic equipment provided in an embodiment of the present invention based on biofeedback technology
Big circuit theory diagrams；
Fig. 6 is that the right leg of the self-closing disease acupoint stimulation therapeutic equipment provided in an embodiment of the present invention based on biofeedback technology drives
Dynamic circuit theory diagrams；
Fig. 7 is that the rear class of the self-closing disease acupoint stimulation therapeutic equipment provided in an embodiment of the present invention based on biofeedback technology is put
Big circuit theory diagrams；
Fig. 8 is the normal person of the self-closing disease acupoint stimulation therapeutic equipment provided in an embodiment of the present invention based on biofeedback technology
Electroculogram when eyes rule is unenhanced；
Fig. 9 is the normal person of the self-closing disease acupoint stimulation therapeutic equipment provided in an embodiment of the present invention based on biofeedback technology
Eyes find electroculogram during purpose thing.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
It is of the invention mainly to use the signal modulating system based on eye electricity biofeedback, it is look at object using autism children
And electro-ocular signal caused by the exchange activity of conscious purpose, regulate and control the output of conventional electroacupuncture stimulation signal.In the present invention, eye
The selection and output of electric signal, and regulation and control of the output signal to acusector signal.
The wherein output system of acusector is as common acusector, and its input signal is the electro-ocular signal after modulation, by the letter
Number regulation and control electroacupuncture stimulation granting.
The application principle of the present invention is further described below in conjunction with the accompanying drawings.
Such as Fig. 1：A kind of control method of the self-closing disease acupoint stimulation therapeutic equipment based on biofeedback technology, the control method
Including：
Electro-ocular signal is gathered by signal input system, signal input system passes through for gathering horizontal channel electro-ocular signal
Horizontal direction two electrodes of HEOL and HEOR, the VEOL and VEOU two of vertical direction for gathering vertical electro-ocular signal
Electrode, GND reference electrodes collection autism children are look at eye telecommunications caused by the exchange activity of object and conscious purpose
Number；
Electro-ocular signal is screened by eye electrical activity gathering system, signal acquisition screening system, handled, to discriminating
Not, the electro-ocular signal after handling is transported to electric acupuncture apparatus；
Electric acupuncture apparatus will receive electro-ocular signal and be transferred to acupoint stimulation system；
Acupoint stimulation system instructs according to electric acupuncture apparatus and carries out electronic stimulation to acupuncture point.
It is to be adjusted by eye electrical activity gathering system, signal acquisition screening system that the electric acupuncture apparatus, which will receive electro-ocular signal,
Letter after control.
Such as Fig. 2：A kind of self-closing disease acupoint stimulation therapeutic equipment based on biofeedback technology, including signal acquiring system and letter
Number processing and output system；The signal acquiring system includes signal input system 1, eye electrical activity gathering system 2；
Such as Fig. 3：The eye electrical activity gathering system 2 includes the input signal circuit after shielding, pre-amplification circuit, the right side
Leg drive circuit, rear class amplifying circuit；
The signal transacting and output system include signal acquisition screening system 3, electric acupuncture apparatus 4 and acupoint stimulation system 5；
The signal acquisition screening system includes eye electricity acquisition module and eye electric treatment module；
The signal input system 1 is connected by signal with the input signal circuit input after shielding, defeated after shielding
Enter signal circuit output end to be connected with pre-amplification circuit input；Pre-amplification circuit output end all the way with driven-right-leg circuit
Connection, another way are connected with rear class input amplifier, and rear class amplification circuit output end is adopted by the signal of output with eye electricity
Collect module input connection, eye electricity acquisition module output end electrically connects with eye electric treatment module input, and eye electric treatment module is defeated
Go out end to electrically connect with electric acupuncture apparatus input, electric acupuncture apparatus output end is connected with acupoint stimulation system；
The signal input system 1 includes the AgCl electrodes for being used for gathering electro-ocular signal of bipolar lead mode, described
AgCl electrodes are connected with the input signal circuit signal after shielding, and the AgCl electrodes include being used to gather horizontal channel eye telecommunications
Number horizontal direction two electrodes of HEOL and HEOR, the VEOL and VEOU two of vertical direction for gathering vertical electro-ocular signal
Individual electrode, GND reference electrodes；Described two electrodes of HEOL and HEOR are arranged in outside the left and right ectocanthion of subject
2.5cm place；Described two electrodes of VEOL and VEOU are arranged on the right eyebrow of subject at 2cm and right lower lid,eye 2cm, described
GND reference electrodes are placed on the forehead of subject；
The acupoint stimulation system includes the acupoint stimulation device positioned at subject acupuncture point and connected by signal and electric acupuncture apparatus
Connect.
The GND reference electrodes of the AgCl electrodes of the collection electro-ocular signal are 1 or 3.
Such as Fig. 4：The signal of input signal circuit reception signal input system input after the shielding, passes through screening arrangement
Signal is shielded；Signal after shielding is connected with instrument amplifier INA333 generating positive and negative voltage input all the way, and instrument is put
Big device INA333 generating positive and negative voltage both ends are connected with 510 kilo-ohms of resistance；All the way with the output of 1/2 OPA2333 operational amplifiers
End connection and simultaneously is connected with the negative input of 1/2 OPA2333 operational amplifiers, 1/2 OPA2333 operational amplifiers it is defeated
Go out end to be connected with the negative pole end of the 2nd 1/2 OPA2333 operational amplifiers by resistance and the one 390 kilo-ohm of parallel connection
Resistance, the output ends of another 1/2 OPA2333 operational amplifiers are connected by the 2nd 390 kilo-ohm of the resistance of connecting with right leg.
Such as Fig. 5：The pre-amplification circuit receives two input signals after shielding, two input signals respectively with C1 and
C2 capacitance connections, positive terminal of the C1 and C2 electric capacity output end respectively with OPA2333-A and OPA2333-B are connected, C1 and C2 electric capacity
10 megaohms of resistance R1 and R2 is connected between output end simultaneously；OPA2333-A and OPA2333-B output end respectively with INA333
The 2nd negative pole and the 3rd positive terminal connection, the INA333 external 1.65 volts of voltage of the 5th pin, INA333 the 7th pin external 3.3
Positive voltage is lied prostrate, the 1st pin is connected with the 8th pin by 510 kilo-ohms of resistance, and OPA233-A and OPA2333-B output end are simultaneously
It is connected with 100 kilo-ohms of R29 and R28.
Such as Fig. 6：The driven-right-leg circuit receives two input signals of pre-amplification circuit, two input signal difference
With C1 and C2 capacitance connections, positive terminal of the C1 and C2 electric capacity output end respectively with OPA1 and OPA2 is connected, the output of C1 and C2 electric capacity
10 megaohms of resistance R1 and R2 is connected between end simultaneously；OPA1 and OPA2 output end respectively with INA333 the 2nd negative pole and the 3rd
Positive terminal connects, and the INA333 external 1.65 volts of voltage of the 5th pin, the INA333 external 3.3 volts of positive voltages of the 7th pin, the 1st draws
Pin is connected with the 8th pin by 510 kilo-ohms of resistance R3, and OPA1 and OPA2 output end are connected with 100 kilo-ohms of R29 and R28 simultaneously,
100 kilo-ohms of R29 and R28 output ends and OPA3 positive terminal are connected, and OPA3 negative pole ends are connected by polarity line and OPA3 output ends
Connect, OPA3 output ends are connected by 20 kilo-ohms of R30 and OPA4 negative pole end, while the electric capacity C17 in parallel with OPA4 and 300,000
It is connected after the R32 connections in Europe, electric capacity C17 and 300 kilo-ohms of R32 parallel connections with OPA4 output end, OPA4 output end and right leg
Connection, OPA4 positive terminal are parallel with electric capacity C13,40 kilo-ohms of R34,40 kilo-ohms of R33, and 40 kilo-ohms of R34 and electric capacity C13 are simultaneously
Output head grounding after connection, 40 kilo-ohms of R33 are connected to the volt of voltage -3.3.
Such as Fig. 7：The signal that the rear class amplifying circuit receives pre-amplification circuit transmission transmits by electric capacity C6 output ends
Positive terminal to OPA1 while 1 megaohm of the R4 in electric capacity C6 output end earths；OPA1 output end connects 31 kilo-ohms
R7 inputs, R7 output ends connect 31 kilo-ohms of R8 inputs while shunt capacitance C12, electric capacity C12 output end output signals；R8
Output end and OPA2 positive terminal connect, and OPA2 output end output signal, R8 output ends connect electric capacity C7 simultaneously, and electric capacity C7 is defeated
Go out end to be grounded all the way, connect 10 kilo-ohms of R9 all the way, R9 output end connects OPA2 negative pole end all the way, connects 15 kilo-ohms all the way
R10 by signal output；Be grounded all the way by connecting 10 kilo-ohms of R5 in OPA1 negative pole end, all the way by 37 kilo-ohms of R6 and
1 kilo-ohm of adjustable resistance R7 of series connection is connected with 31 kilo-ohms of R7 inputs.
The Eyeball motion information of patient is gathered first, and it is specific eye movement feature (bag to be look at object according to children
Include the static of longer period of time) the eye electrical activity that is showed, pupil size when being look at object according to autism children,
As the foundation of infantile psychology change, regular instructions are sent, allow electric needle therapeutic instrument to export specific therapeutic frequency.
Specific embodiment：
Such as Fig. 8 and Fig. 9：
The signal collected preliminary result as shown in Figure 8,9, shows i.e. when bilateral electro-ocular signal is when one continuous
Between can reach more than the three as depicted eye electrical activities more than 180mv peak values in the cycle (such as in 1 second), and be believed that
There is autotelic eye electrical activity in it, then it is (such as most common to electric acupuncture apparatus that can by main controller sends a stimulation instructions
G6805 types electric acupuncture apparatus), make it maintain one to be up to the low frequency stimulating of 30 seconds, and be output on the stimulating electrode on acupuncture point surface.
Because each infant is different to the tolerance degree of stimulation, it is desirable to which each infant must regulate before the treatment adapts to it
The optimal stimulus intensity (i.e. the stimulus intensity output knob of acusector is adjustable) of individual, can just start stable use afterwards.Change speech
The process must be completed under the guidance of acupuncturist.
Normal person's eyes find purpose thing when electroculogram due to horizontal eye electricity HEOG Amplitude Rations it is larger, by experiment sentence
Fixed, activity of the horizontal eye electrical activity amplitude more than 200uv is determined as purposeful and meaning ocular movemeut at once, and vertical eye electricity is mutually
Activity of the dynamic amplitude more than 150uv is determined as significant ocular movemeut at once.
Control method with reference to the self-closing disease acupoint stimulation therapeutic equipment based on biofeedback technology enters one to the present invention
Walk explanation：
Controlled by eye electric system, with the purposeful motion of eyeball, and send a stimulus signal, notice electric acupuncture apparatus starts
Work；
Conventional electric acupuncture apparatus, such as G6805 type electric acupuncture apparatus, often it is connected to the low frequency that one action signal is issued by once being up to 30 seconds
Stimulate (2Hz)；
Acupoint stimulation device of the low frequency stimulating instruction on Baihui acupuncture point or changqiang acupuncture point is stimulating electrode work.
Therapeutic purposes are realized by exporting the electro photoluminescence (frequency of stimulation, amplitude are adjustable) of a series of 30 seconds by a definite date.
Clinical practice of the traditional acupuncture therapy to " god " is combined by the present invention with the eye electroanalysis and the inspection technology of picking up in modern times,
Change the blindness on intervention in the past Acupuncture Clinical, i.e., can only passively receive to control in outpatient clinic by patient
Treat, and can not selectively, with having opportunity carry out therapeutic intervention, realizing has the physician practice of purpose in Acupuncture Clinical.
The invention reside in the treatment means for expanding Acupuncture Clinical, will be based on modern biomedical current research technology first and means are drawn
Enter into traditional acupuncture treatment clinic, realize the optimum integration of the two, this treatment thoughts and method are original.The present invention
The treatment in autism is not only applied, but all about treat traditional acupuncture (is adjusted, nothing without output after containing
Time effect, traditional acupoint stimulation of inanimate object feed-back regulatory mechanism) utilize the institute of biofeedback technology development acupuncture and moxibustion therapy
There is invention thinking.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
All any modification, equivalent and improvement made within refreshing and principle etc., should be included in the scope of the protection.
Claims (6)
1. a kind of self-closing disease acupoint stimulation therapeutic equipment based on biofeedback technology, it is characterised in that biofeedback skill should be based on
The self-closing disease acupoint stimulation therapeutic equipment of art includes signal acquiring system and signal transacting and output system, the signal acquiring system
Including signal input system, eye electrical activity gathering system；The eye electrical activity gathering system includes the input letter after shielding
Number circuit, pre-amplification circuit, driven-right-leg circuit, rear class amplifying circuit；The signal transacting and output system include signal
Gather screening system, electric acupuncture apparatus and acupoint stimulation system；
The signal acquisition screening system includes eye electricity acquisition module and eye electric treatment module；The signal input system passes through letter
Number with shielding after input signal circuit input be connected, the input signal circuit output end and pre-amplification circuit after shielding are defeated
Enter end connection；Pre-amplification circuit output end is connected with driven-right-leg circuit all the way, another way and rear class input amplifier
Connection, rear class amplification circuit output end are connected by the signal of output with eye electricity acquisition module input, and eye electricity acquisition module is defeated
Go out end to electrically connect with eye electric treatment module input, eye electric treatment module output end electrically connects with electric acupuncture apparatus input, electric acupuncture apparatus
Output end is connected with acupoint stimulation system；
The signal input system includes the AgCl electrodes for being used for gathering electro-ocular signal of bipolar lead mode, the AgCl electrodes
It is connected with the input signal circuit signal after shielding, the AgCl electrodes include being used for the level for gathering horizontal channel electro-ocular signal
Two electrodes of HEOL and HEOR in direction, the vertical direction for gathering vertical electro-ocular signal two electrodes of VEOL and VEOU,
GND reference electrodes；Described two electrodes of HEOL and HEOR are arranged at the 2.5cm outside the left and right ectocanthion of subject；Institute
State two electrodes of VEOL and VEOU to be arranged at right the upper eyebrow 2cm and right lower lid,eye 2cm of subject, the GND references
Electrode is placed on the forehead of subject；
The acupoint stimulation system includes the acupoint stimulation device positioned at subject acupuncture point and is connected by signal with electric acupuncture apparatus.
2. the self-closing disease acupoint stimulation therapeutic equipment based on biofeedback technology as claimed in claim 1, it is characterised in that；It is described
The GND reference electrodes for gathering the AgCl electrodes of electro-ocular signal are 1 or 3.
3. the self-closing disease acupoint stimulation therapeutic equipment based on biofeedback technology as claimed in claim 1, it is characterised in that described
The signal of input signal circuit reception signal input system input after shielding, is shielded by screening arrangement to signal；Screen
Signal after covering is connected with instrument amplifier INA333 generating positive and negative voltage input all the way, instrument amplifier INA333 positive negative electricity
Pressure both ends are connected with 510 kilo-ohms of resistance；It is connected all the way with the output end of 1/2 OPA2333 operational amplifiers and simultaneously with 1/2
The negative input connection of OPA2333 operational amplifiers, the output ends of 1/2 OPA2333 operational amplifiers by a resistance with
The negative pole end connection of 2nd 1/2 OPA2333 operational amplifiers and resistance in parallel one 390 kilo-ohm, another 1/2
The output end of OPA2333 operational amplifiers is connected by the 2nd 390 kilo-ohm of the resistance of connecting with right leg.
4. the self-closing disease acupoint stimulation therapeutic equipment based on biofeedback technology as claimed in claim 1, it is characterised in that described
Pre-amplification circuit receive shielding after two input signals, two input signals respectively with C1 and C2 capacitance connections, C1 and C2
Positive terminal of the electric capacity output end respectively with OPA2333-A and OPA2333-B is connected, and is connected simultaneously between C1 and C2 electric capacity output ends
10 megaohms of resistance R1 and R2；OPA2333-A and OPA2333-B output end respectively with INA333 the 2nd negative pole and the 3rd positive pole
End connection, the INA333 external 1.65 volts of voltage of the 5th pin, the INA333 external 3.3 volts of positive voltages of the 7th pin, the 1st pin with
8th pin is connected by 510 kilo-ohms of resistance, OPA233-A and OPA2333-B output end be connected with simultaneously 100 kilo-ohms R29 and
R28。
5. the self-closing disease acupoint stimulation therapeutic equipment based on biofeedback technology as claimed in claim 1, it is characterised in that described
Driven-right-leg circuit receive pre-amplification circuit two input signals, two input signals respectively with C1 and C2 capacitance connections,
Positive terminal of the C1 and C2 electric capacity output end respectively with OPA1 and OPA2 is connected, connection 10,000,000 simultaneously between C1 and C2 electric capacity output ends
The resistance R1 and R2 in Europe；OPA1 and OPA2 output end is connected with INA333 the 2nd negative pole and the 3rd positive terminal respectively, INA333
The external 1.65 volts of voltage of the 5th pin, the INA333 external 3.3 volts of positive voltages of the 7th pin, the 1st pin passes through with the 8th pin
510 kilo-ohms of resistance R3 connections, OPA1 and OPA2 output end is connected with 100 kilo-ohms of R29 and R28 simultaneously, 100 kilo-ohms of R29 and
R28 output ends and OPA3 positive terminal are connected, and OPA3 negative pole ends are connected by polarity line with OPA3 output ends, and OPA3 output ends are led to
20 kilo-ohms of R30 and OPA4 negative pole end connection is crossed, while the electric capacity C17 in parallel with OPA4 and 300 kilo-ohms of R32 are connected, electricity
It is connected after holding C17 and 300 kilo-ohm of R32 parallel connections with OPA4 output end, OPA4 output end is connected with right leg, OPA4 positive pole
End is parallel with electric capacity C13,40 kilo-ohms of R34,40 kilo-ohms of R33, output head grounding after 40 kilo-ohms of R34 and electric capacity C13 parallel connections,
40 kilo-ohms of R33 is connected to the volt of voltage -3.3.
6. the self-closing disease acupoint stimulation therapeutic equipment based on biofeedback technology as claimed in claim 1, it is characterised in that described
The signal that rear class amplifying circuit receives pre-amplification circuit transmission is transferred to OPA1 positive terminal simultaneously by electric capacity C6 output ends
In 1 megaohm of R4 of electric capacity C6 output end earths；OPA1 output end connects 31 kilo-ohms of R7 inputs, and R7 output ends connect
Connect 31 kilo-ohms of R8 inputs while shunt capacitance C12, electric capacity C12 output end output signals；The positive pole of R8 output ends and OPA2
End connection, OPA2 output end output signal, R8 output ends connect electric capacity C7 simultaneously, and electric capacity C7 output ends are grounded all the way, all the way
10 kilo-ohms of R9 of connection, R9 output end connect OPA2 negative pole end all the way, connect 15 kilo-ohms of R10 all the way by signal output；
It is grounded all the way by connecting 10 kilo-ohms of R5 in OPA1 negative pole end, it is adjustable by 1 kilo-ohm of 37 kilo-ohms of R6 and series connection all the way
Resistance R7 is connected with 31 kilo-ohms of R7 inputs.
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| CN1718155A (en) * | 2005-07-21 | 2006-01-11 | 高春平 | Multi-functional device for regulating physiological signals |
| CN102125429A (en) * | 2011-03-18 | 2011-07-20 | 上海交通大学 | Alertness detection system based on electro-oculogram signal |
| CN103182159A (en) * | 2012-08-30 | 2013-07-03 | 胡琦逸 | Lower limb rehabilitation training device based on electro-oculogram signal control |
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| CN1718155A (en) * | 2005-07-21 | 2006-01-11 | 高春平 | Multi-functional device for regulating physiological signals |
| CN102125429A (en) * | 2011-03-18 | 2011-07-20 | 上海交通大学 | Alertness detection system based on electro-oculogram signal |
| CN103182159A (en) * | 2012-08-30 | 2013-07-03 | 胡琦逸 | Lower limb rehabilitation training device based on electro-oculogram signal control |
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