CN105560378A - New use of mulberry leaf total flavonoids - Google Patents
New use of mulberry leaf total flavonoids Download PDFInfo
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- CN105560378A CN105560378A CN201511017625.XA CN201511017625A CN105560378A CN 105560378 A CN105560378 A CN 105560378A CN 201511017625 A CN201511017625 A CN 201511017625A CN 105560378 A CN105560378 A CN 105560378A
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- total flavonoids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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- General Health & Medical Sciences (AREA)
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Abstract
The invention provides a new use of mulberry leaf total flavonoids, concretely relates to a use of the mulberry leaf total flavonoids in anti-depression treatment, and an application of the mulberry leaf total flavonoids as an anti-depression treatment drug. Research results of in vivo experiments and in vitro experiments show that the mulberry leaf total flavonoids can rapidly and substantially improve depression and anxiety symptoms; and compared with traditional anti-depression drugs, the mulberry leaf total flavonoids have the advantages of low toxicity, small side effects, and safety in use.
Description
Technical field
The present invention relates to the novelty teabag of Folium Mori total flavonoids, be specifically related to Folium Mori total flavonoids at the antidepressant novelty teabag for the treatment of, belong to field of pharmaceutical technology.
Background technology
Depression, with its high incidence, high disability rate and serious suicidal tendency, has become a public health problem.The pathogenesis of current depression it be unclear that, and research in the past thinks that the many factors such as depression is lacked of proper care with inflammation, monoamine neurotransmitter, hpa axis is activated are relevant.In treatment, present stage antidepressant drug clinically often have the drawbacks such as onset is slow, medicine usefulness is low, side effect is large.Therefore, rapid-action, that usefulness is high, side effect is little antidepressant drug the is current antidepressant research task of top priority is found.Current antidepressant drug declines mainly for monoamine neurotransmitter, specifically has: the antidepressant drug of tricyclic antidepressants, as imipramine, amitriptyline; Selectivity serotonin reuptake inhibitors, as Fu Luoxiting etc.On animal model, these medicines can reduce the dead time of forced swimming and tail-suspention test, and increase the time of contact of social stress's failure model small mouse.With it depressive patients, the symptom of some patients also can be made to be eased.
Existing antidepressant drug has 3 large shortcomings: first, usefulness is low, only 35 45% patient's routine administration after, depressive symptom is eased.Secondly, drug effect is slow, need at least 3-5 week ability onset, and a lot of patient is difficult to adhere to that obtaining curative effect just abandons treatment.In addition, also there is many side effect in existing antidepressants, and as sexual dysfunction, sleep disorder, puts on weight.
Summary of the invention
In view of current above shortcomings in anti depressant therapy, the invention provides the novelty teabag of Folium Mori total flavonoids, can significantly improve depression and anxiety symptom fast, and compared with traditional antidepressant drug, toxicity is low, side effect is little, use safety.
Concrete technical scheme is as follows:
The invention provides the novelty teabag of Folium Mori total flavonoids, Folium Mori total flavonoids is as the purposes in anti depressant therapy.
According to the principle of the present invention, Folium Mori total flavonoids is as the application in anti depressant therapy medicine.
According to the principle of the present invention, containing Folium Mori total flavonoids in prepared treatment anti depressant therapy medicine.
According to the principle of the present invention, be effective active composition with Folium Mori total flavonoids in prepared treatment anti depressant therapy medicine.
According to the principle of the present invention, in anti depressant therapy, the antidepressant concentration of Folium Mori total flavonoids is 50mg/kg-100mg/kg.
According to the principle of the present invention, described in anti depressant therapy the antidepressant concentration of Folium Mori total flavonoids be 50mg/kg or 100mg/kg.
Another side of the present invention, a kind of preparation method of Folium Mori total flavonoids, comprises the following steps:
Folium Mori use 70% alcohol reflux 2 times after 60 DEG C of dryings, each 2h, rotary evaporation, concentrating under reduced pressure;
After macroporous adsorbent resin separation and purification, obtain Folium Mori total flavonoids former state through concentrated sample, be made into 0.5g/L concentration, 4 DEG C save backup.
The novelty teabag of principle of the invention Folium Mori total flavonoids, be specially Folium Mori total flavonoids as the purposes in anti depressant therapy, and Folium Mori total flavonoids is as the application in anti depressant therapy medicine, the novelty teabag of Folium Mori total flavonoids of the present invention, the result of study according to experiment in vivo and experiment in vitro shows, Folium Mori total flavonoids Cure of depression advantage is as follows: can significantly improve depression and anxiety symptom fast, and compared with traditional antidepressant drug, toxicity is low, and side effect is little, use safety.
Accompanying drawing explanation
By reading the detailed description done non-limiting example with reference to the following drawings, the present invention and feature, profile and advantage will become more obvious.Labelling identical in whole accompanying drawing indicates identical part.Deliberately proportionally do not draw accompanying drawing, focus on purport of the present invention is shown.
Fig. 1 is the schematic diagram of Folium Mori total flavonoids novelty teabag small mouse provided by the invention at forced swim test.
Fig. 2 is the schematic diagram of Folium Mori total flavonoids novelty teabag small mouse provided by the invention at tail-suspention test.
Fig. 3 is the schematic diagram that Folium Mori total flavonoids novelty teabag small mouse provided by the invention is tested in spacious field.
Fig. 4 a and Fig. 4 b is the schematic diagram of Folium Mori total flavonoids novelty teabag small mouse provided by the invention at new environment fasting Inhibition test.
Fig. 5 a and Fig. 5 b is the schematic diagram of Folium Mori total flavonoids novelty teabag small mouse provided by the invention in social stress's failure model experiment.
Detailed description of the invention
In the following description, a large amount of concrete details is given to provide more thorough understanding of the invention.But, it is obvious to the skilled person that the present invention can be implemented without the need to these details one or more.In other example, in order to avoid obscuring with the present invention, technical characteristics more well known in the art are not described.
In order to thoroughly understand the present invention, detailed step and concrete structure will be proposed in following description, to explain technical scheme of the present invention.Best case study on implementation of the present invention is described in detail as follows, but except these are described in detail, the present invention can also have other embodiment.
The invention provides the novelty teabag of Folium Mori total flavonoids, wherein Folium Mori are a kind of Chinese medicine of integration of edible and medicinal herbs, and traditional medicine thinks that it has the effect of clearing away lung-heat and moistening for dryness, clearing away liver-fire.Modern study proves, Folium Mori total flavonoids (MTF) also has the multiple efficacies such as antiinflammatory, antioxidation, blood pressure lowering, blood sugar lowering, blood fat reducing.
In an alternate embodiment of the present invention, Folium Mori total flavonoids is as the purposes in anti depressant therapy.
In an alternate embodiment of the present invention, Folium Mori total flavonoids is as the application in anti depressant therapy medicine.
In an alternate embodiment of the present invention, containing Folium Mori total flavonoids in the treatment anti depressant therapy medicine of preparation.
In an alternate embodiment of the present invention, be effective active composition with Folium Mori total flavonoids in the treatment anti depressant therapy medicine of preparation.
In an alternate embodiment of the present invention, in anti depressant therapy, the antidepressant concentration of Folium Mori total flavonoids is 50mg/kg-100mg/kg, more preferably 50mg/kg or 100mg/kg.
Another side of the present invention, a kind of preparation method of Folium Mori total flavonoids, comprises the following steps:
Step S1: Folium Mori use 70% alcohol reflux 2 times after 60 DEG C of dryings, each 2h, rotary evaporation, concentrating under reduced pressure.
Step S2: obtain Folium Mori total flavonoids former state through concentrated sample after macroporous adsorbent resin separation and purification, be made into 0.5g/L concentration, 4 DEG C save backup.
Below provide concrete experiment to prove novelty teabag of the present invention.
One, the preparation of sample
1, the preparation of Folium Mori total flavonoids: after Folium Mori 60 DEG C of dryings, 70% alcohol reflux 2 times, each 2h, rotary evaporation, concentrating under reduced pressure.Sample obtains Folium Mori total flavonoids former state after macroporous adsorbent resin separation and purification, and be made into 0.5g/L concentration, 4 DEG C save backup.
2, male C 57 BL/6 J mouse (8-11 week size) is purchased from Guangdong Province's Experimental Animal Center.Mice at the standard conditions (free diet drinking-water, cage 300mm × 170mm × 120mm size, room temperature 23 ± 1 DEG C, illumination 12h is bright/12h is dark) raise after 1 week for experiment.
Two, experimental technique
(1), forced swim test, wherein forced swim test is carry out in transparent large glass jar (height 45cm, diameter 19cm), and depth of water 23cm, water temperature maintains 22-25 DEG C.Test and complete administration in first 30 minutes, the testing time is 6 minutes, records the dead time of last 4 minutes under single blind condition.
As shown in Figure 1, wherein often organize 50 mices, significantly can reduce the dead time of mice in forced swim test at the Folium Mori total flavonoids of 50mg/kg and 100mg/kg, there is antidepressant effects.
(2), tail-suspention test, wherein tail-suspention test is for fix 1/3 place's adhesive tape after mouse tail, hangs on support, head distance table top 15cm.Test and complete administration in first 30 minutes, the testing time is 6 minutes, records the dead time of last 4 minutes under single blind condition.
As shown in Figure 2, wherein often organize 50 mices, significantly can reduce the dead time of mice in tail-suspention test experiment at the Folium Mori total flavonoids of 50mg/kg and 100mg/kg, there is antidepressant effects.
(3), the experiment of spacious field, wherein the experiment of spacious field for carry out in a rectangle polrvinyl chloride box (40cm × 40cm × 30cm), and mice puts down the central authorities in box gently, freely explores 5 minutes.Induction apparatus is equipped with in the bottom of box, automatically can record the distance of mice experience.
As shown in Figure 3, wherein often organize 50 mices, the behavioral competence of Folium Mori total flavonoids to mice does not impact, illustrate that the reduction of dead time in forced swim test and tail-suspention test is not because Folium Mori total flavonoids causes mice physical exertion, further illustrate the antidepressant effects of Folium Mori total flavonoids.
(4), new environment fasting Inhibition test, wherein new environment fasting Inhibition test is use the proof box spreading even 2cm at the bottom of length of side 50cm, high 40cm case, and fritter Mus grain is placed on blank sheet of paper by central authorities at the bottom of case.Test before mice fasting 24h, put in mice cartonning from arbitrary case angle during test, observe 5min by camera system, record mice activity, calculate simultaneously by put into mice to mice forelimb take in one's arms sugar pill feed latent time (latency).Subsequently mice is put back in cage and record food consumption quantity in 5min, to get rid of the impact of appetite difference on eating time.
As shown in fig. 4 a, wherein often organize 50 mices, mice feeding incubation period in new environment fasting Inhibition test significantly can be reduced at 50mg/kg Folium Mori total flavonoids, there is antidepressant effects, as shown in Figure 4 b, in new environment fasting Inhibition test, two groups of mices do not show the difference of food ration, illustrate that the hunger intensity of mice does not have significant difference, the mice feed of injection Folium Mori total flavonoids is short for incubation period, be not due to this group mice more hungry, but due to they impression pressure less.
(5), social stress's failure model, wherein social stress's failure model is in the model, the tested mice that single cage is raised and one unfamiliarly to put together 10 days with aggressive CD1 mice completely, 10 minutes every days attack time, all the other times carve leaky plastic cover plate separately with one.Control mice strain identical with it but unfamiliar mice are put together, contact the time of 10 minutes every day, rear quarter leaky plastic septum separately.Its behavioral indexes avoids measuring by social communication.Method is, first mice is put into the plastic casing of a 50cm × 50cm × 20cm, and a transparent porose plexiglass box is placed, high 15cm by box side central authorities.Contacts region is marked around lucite box.Record mice in 2.5 minutes, in the time of staying in contacts region, to be designated as T1, then mice to be put back to former mouse cage and have a rest 1 minute, with the alcohol wipe plastic casing of 70%, to remove the abnormal smells from the patient of mice.Then CD1 mice is put in lucite box, experiment mice is put back in box again, record mice in 2.5 minutes and, in the time of staying in contacts region, be designated as T2.Using the ratio of T2 and T1 as Testing index, when ratio is greater than 1, mice is decided to be the insensitive mice of this stimulation by we, otherwise when ratio is less than 1, mice is decided to be the mice to this stimulation sensitivity by us.
As shown in figure 5 a and 5b, wherein often organize 50 mices, in social stress's failure model, Folium Mori total flavonoids successive administration 14 days (50mg/kg) can make mice show antidepressant behavior; The onset of traditional antidepressant drug imipramine then needs 28 days.(Con, normal mouse.Sal, gives the mice of saline therapy after society's failure modeling.MTF, to the mice of Folium Mori total flavonoids treatment after society's failure modeling.Imi, to the mice of imipramine treatment after society's failure modeling.*, p<0.05 compared with Con group.#, p<0.05 compared with Sal group.）
To sum up, the novelty teabag of principle of the invention Folium Mori total flavonoids, be specially Folium Mori total flavonoids as the purposes in anti depressant therapy, and Folium Mori total flavonoids is as the application in anti depressant therapy medicine, the novelty teabag of Folium Mori total flavonoids of the present invention, in anti depressant therapy, the antidepressant concentration of Folium Mori total flavonoids is 50mg/kg or 100mg/kg, result of study according to experiment in vivo and experiment in vitro shows, Folium Mori total flavonoids Cure of depression advantage is as follows: can significantly improve depression and anxiety symptom fast, and compared with traditional antidepressant drug, toxicity is low, side effect is little, use safety.
Above preferred embodiment of the present invention is described.It is to be appreciated that the present invention is not limited to above-mentioned particular implementation, the equipment wherein do not described in detail to the greatest extent and structure are construed as to be implemented with the common mode in this area; Any those of ordinary skill in the art, do not departing under technical solution of the present invention ambit, the Method and Technology content of above-mentioned announcement all can be utilized to make many possible variations and modification to technical solution of the present invention, or being revised as the equivalent case study on implementation of equivalent variations, this does not affect flesh and blood of the present invention.Therefore, every content not departing from technical solution of the present invention, according to technical spirit of the present invention to any simple modification made for any of the above embodiments, equivalent variations and modification, all still belongs in the scope of technical solution of the present invention protection.
Claims (7)
1. the novelty teabag of Folium Mori total flavonoids, is characterized in that, Folium Mori total flavonoids is as the purposes in anti depressant therapy.
2. the novelty teabag of Folium Mori total flavonoids as claimed in claim 1, it is characterized in that, Folium Mori total flavonoids is as the application in anti depressant therapy medicine.
3. the novelty teabag of Folium Mori total flavonoids as claimed in claim 2, is characterized in that, containing Folium Mori total flavonoids in prepared treatment anti depressant therapy medicine.
4. the novelty teabag of Folium Mori total flavonoids as claimed in claim 3, is characterized in that, is effective active composition with Folium Mori total flavonoids in prepared treatment anti depressant therapy medicine.
5. the novelty teabag of the Folium Mori total flavonoids as described in as arbitrary in claim 1-4, it is characterized in that, in anti depressant therapy, the antidepressant concentration of Folium Mori total flavonoids is 50mg/kg-100mg/kg.
6. the novelty teabag of Folium Mori total flavonoids as claimed in claim 4, is characterized in that, described in anti depressant therapy the antidepressant concentration of Folium Mori total flavonoids be 50mg/kg or 100mg/kg.
7. a preparation method for Folium Mori total flavonoids, is characterized in that, comprises the following steps:
Folium Mori use 70% alcohol reflux 2 times after 60 DEG C of dryings, each 2h, rotary evaporation, concentrating under reduced pressure;
After macroporous adsorbent resin separation and purification, obtain Folium Mori total flavonoids former state through concentrated sample, be made into 0.5g/L concentration, 4 DEG C save backup.
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| CN201511017625.XA CN105560378A (en) | 2015-12-29 | 2015-12-29 | New use of mulberry leaf total flavonoids |
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| CN201511017625.XA CN105560378A (en) | 2015-12-29 | 2015-12-29 | New use of mulberry leaf total flavonoids |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2802977C1 (en) * | 2022-11-20 | 2023-09-05 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Use of patulythrin as an antidepressant |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244124A (en) * | 2008-02-22 | 2008-08-20 | 浙江大学 | Method of preparing mulberry leaf active site and application |
| CN102370707A (en) * | 2010-08-25 | 2012-03-14 | 上海辉文生物技术有限公司 | Method for preparing mulberry leaf and/or mulberry twig extract, obtained product thereof and application thereof |
| CN104189087A (en) * | 2014-08-12 | 2014-12-10 | 山东天智绿业生物科技有限公司 | Method for extracting total flavonoid functional substance from folium mori |
-
2015
- 2015-12-29 CN CN201511017625.XA patent/CN105560378A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244124A (en) * | 2008-02-22 | 2008-08-20 | 浙江大学 | Method of preparing mulberry leaf active site and application |
| CN102370707A (en) * | 2010-08-25 | 2012-03-14 | 上海辉文生物技术有限公司 | Method for preparing mulberry leaf and/or mulberry twig extract, obtained product thereof and application thereof |
| CN104189087A (en) * | 2014-08-12 | 2014-12-10 | 山东天智绿业生物科技有限公司 | Method for extracting total flavonoid functional substance from folium mori |
Non-Patent Citations (2)
| Title |
|---|
| 刘小雪等: ""大孔吸附树脂纯化桑叶总黄酮的工艺优化"", 《光明中医》 * |
| 陈蕾: ""黄酮类化合物的抗抑郁作用研究"", 《国际精神病学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2802977C1 (en) * | 2022-11-20 | 2023-09-05 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Use of patulythrin as an antidepressant |
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