CN105550526B - A kind of tcm prescription effect quantitative approach and system based on Chinese medicine attribute - Google Patents
A kind of tcm prescription effect quantitative approach and system based on Chinese medicine attribute Download PDFInfo
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Abstract
The present invention provides a kind of tcm prescription effect quantitative approach and system based on Chinese medicine attribute, can determine the effect of prescription is whole value according to influencing each other between each effect of drug each in prescription.The method includes：Prescription is obtained, determines that the attribute of each drug and practical dose, the attribute include in prescription：Pharmacological property, flavour of a drug, channel tropism and effect；According to preset Traditional chinese medicine medicament database, the interaction coefficient between each each effect of drug in prescription is determined；The practical dose of drug each in prescription is standardized as opposite dose, and the efficacy strength of various single effects that the opposite dose of each drug is had as corresponding drug；Using the opposite dose of drug each in prescription as the weights of corresponding drug attribute, and value the effect of the interaction coefficient combined in prescription between each each effect of drug determines each effect in prescription.The present invention is suitable for science of TCM formulas technical field.
Description
Technical field
The present invention relates to science of TCM formulas technical fields, particularly relate to a kind of tcm prescription effect based on Chinese medicine attribute and determine
Measure method and system.
Background technology
Tcm prescription (referred to as " prescription ") is clinically referred to as " prescription ", as the main means of Traditional chinese medicine medicament therapy, it
It is that theory of traditional Chinese medical science is applied to one of clinical important behaviour form.In order to output one good recipe of curing the disease, doctor is needed middle medical knowledge
It is organically combined by with clinical experience for many years, (dialectical) is judged for patient symptom sign, then determine therapeutic scheme (opinion
It controls).In clinical practice, there is saying for " for medicine not from side, side not being from card ", prescription is into theory of traditional Chinese medical science and the center ring of tcm clinical practice
Section, thus by industry most attention.For the research of prescription, there is too many profoundness in the behind of prescription, to accomplish both to know it
So know that its reason has no shortcut and can walk again, all needs, which trace back, originally asks source.Prescription is formed by a variety of compatibility of drugs, per medicine simply
Object has corresponding attribute, for example, the pharmacological property (cold, Great Cold, heat, big heat, temperature, tepor, flat, cool, micro- cool) of drug, flavour of a drug (it is sour,
It is bitter, sweet, pungent, salty, flat, puckery, light), channel tropism (small intestine, large intestine, liver, lung, three cokes, kidney, stomach, spleen, bladder, courage, the heart, pericardium) and work(
Effect (heat-clearing Xie Huo, enriches blood, delivers, expelling pathogenic factors from muscles and skin and stomach, lower gas, changes stagnant, removing toxic substances, calms the nerves etc.).
All medical instruments in prescription have the characteristics such as different biologies, chemistry, and in practical recipe drug composition, what is provided is past
Toward the practical dose for being each drug in prescription, and the dosage size of two kinds of each drugs is directly relatively without substantive meaning in Tongfang
Justice.The effect of only cannot judging drug from practical dose size size or for contribution degree size, Prescription Effect quantitatively calculates
Drug is difficult to be placed under same standard and is compared, and have ignored the interaction between each efficacy of drugs attribute, only
The Prescription Effect quantized value only obtained by practical dose is inaccurate.Tcm prescription effect attribute is by drug attribute each in prescription
It influences each other and generates rather than simple machinery superposition, in addition, during patient is from evolution diagnosis and treatment to condition, do not have
Normative medication record, it is not known that efficacy of drugs attribute and drug consumption trend, it is difficult to be visually known the medicine law of user.
Invention content
The technical problem to be solved in the present invention is to provide a kind of tcm prescription effect quantitative approach based on Chinese medicine attribute and
System has ignored phase between each efficacy of drugs attribute to solve traditional Prescription Effect quantitative approach present in the prior art
Interaction, the problem of only obtaining the quantized value of Prescription Effect by practical dose, cause quantized value accuracy rate low.
It is quantified in order to solve the above technical problems, the embodiment of the present invention provides a kind of tcm prescription effect based on Chinese medicine attribute
Method, including：
Prescription is obtained, determines that the attribute of each drug and practical dose, the attribute include in prescription：Pharmacological property, flavour of a drug, channel tropism
And effect；
According to preset Traditional chinese medicine medicament database, the interaction coefficient between each each effect of drug in prescription is determined；
The practical dose of drug each in prescription is standardized as opposite dose, and using the opposite dose of each drug as pair
Answer the efficacy strength of various single effects that drug has；
Using the opposite dose of drug each in prescription as the weights of corresponding drug attribute, and combine each each work(of drug in prescription
The effect of interaction coefficient between effect determines each effect in prescription value.
Further, the acquisition prescription determines before the attribute of each drug and practical dose to include in prescription：
Attribute, practical dose, minimum common dose and the maximum common dose of Traditional chinese medicine medicament and each drug are obtained, and to institute
The attribute for stating Traditional chinese medicine medicament carries out numeralization processing, establishes Traditional chinese medicine medicament database；
It is described according to preset Traditional chinese medicine medicament database, determine the interaction coefficient between each each effect of drug in prescription
Including：
According to the attribute of each drug stored in the Traditional chinese medicine medicament database, the similarity between each effect, shape are determined
Into Traditional chinese medicine medicament database effect similarity matrix；
According to the effect of each drug, being extracted in prescription to Traditional chinese medicine medicament database effect similarity matrix of formation,
Obtain Prescription Effect similarity matrix；
According to the attribute of drug each in prescription, the similarity between each drug in prescription is determined, form drug similarity moment
Battle array；
According to the Prescription Effect similarity matrix of formation and drug similarity matrix, determine in prescription each each effect of drug it
Between interaction coefficient.
Further, the attribute of each drug stored in the Traditional chinese medicine medicament database according to foundation, determines that drug is each
Similarity between effect forms Traditional chinese medicine medicament database effect similarity matrix and includes：
The corresponding average pharmacological property value of each effect, average flavour of a drug value peace in Traditional chinese medicine medicament database are determined by the first formula
Equal channel tropism value vector, first formula are expressed as：
In formula, VeRepresent the corresponding average pharmacological property value of e kind effects, average flavour of a drug value and average channel tropism value vector, VtIt represents
Pharmacological property, flavour of a drug and the channel tropism vector of t kind drugs, t=1,2 ... T represent t kind drugs in Traditional chinese medicine medicament database, and T is represented
The species number of drug, M in Traditional chinese medicine medicament databaseteRepresent e kind effects of t kind drugs, e=1,2 ..., E, E is drug
Effect species number；
The similarity of two kinds of effects is determined by the second formula, second formula is expressed as：
In formula, wpqRepresent the similarity between pth kind effect and q kind effects, VpRepresent that pth kind effect is corresponding average
Pharmacological property value, average flavour of a drug value and average channel tropism value vector, VqRepresent the corresponding average pharmacological property value of q kind effects, average flavour of a drug value
With average channel tropism value vector；
0 to the value between maximum similarity value is divided to obtain multiple similarity dimensions, each similarity dimensions pair
Answer effect interaction value；
According to the similarity dimensions belonging to the similarity value of two kinds of effects, determine that the effect of two kinds of effects correspond to interacts
Value；
The interaction value according to the effect of two kinds of effects builds Traditional chinese medicine medicament database effect similarity matrix.
Further, the attribute according to drug each in prescription determines the similarity between each drug in prescription, is formed
Drug similarity matrix includes：
Similarity in prescription between each drug is determined by third formula, the third formula is expressed as：
In formula, SijRepresent the similarity between i-th kind of drug and jth kind drug, vikAnd vjkI-th, two kinds of j is represented respectively
The numeralization of the kth kind pharmacological property of drug, flavour of a drug or channel tropism attribute is as a result, i, j=1,2 ..., n, n represent the kind of drug in prescription
Class number, k=1,2 ..., K, K represent the total number of medicine property of medicine, flavour of a drug and channel tropism attribute.
Further, the practical dose by drug each in prescription is standardized as including with respect to dose：
Dose and maximum common dose are commonly used, and tie according to the minimum of drug each in the prescription of Traditional chinese medicine medicament database purchase
The practical dose of each drug in prescription is closed, the practical dose of drug each in prescription is standardized as opposite medicine by standardizing formula
Amount；
Wherein, standardization formula is：
In formula,X is the opposite dose of drug, and x is the practical dose of drug, and M is medicine
The maximum of object commonly uses dose, and m is that the minimum of drug commonly uses dose.
Further, the opposite dose using drug each in prescription is as the weights of corresponding drug attribute, and combination side
The effect of interaction coefficient in agent between each each effect of drug determines each effect in prescription value includes：
The effect of determining each effect in prescription by the 4th formula value, the 4th formula are expressed as：
In formula, HPThe effect of representing pth kind effect in prescription value, i, j=1,2 ..., n, n represent each medicament categories in prescription
Number, XipRepresent the efficacy strength of pth kind effect of i-th kind of drug, p=1,2 ..., E, q=1,2 ..., E, E represent effect type
Number, XjqRepresent the efficacy strength of q kind effects of jth kind drug,Represent pth kind effect of i-th kind of drug and jth kind medicine
Interaction coefficient between q kind effects of object.
The embodiment of the present invention also provides a kind of tcm prescription effect quantitative system based on Chinese medicine attribute, including：
Input unit, for inputting prescription information, the prescription information includes：The composition drug of prescription and the reality of each drug
Border dose；
Drug attribute determining unit, for determining the attribute of each drug in prescription, the attribute includes：Pharmacological property, is returned at flavour of a drug
Through and effect；
Effect interaction coefficient determination unit, for according to preset Traditional chinese medicine medicament database, determining each medicine in prescription
Interaction coefficient between each effect of object；
Standardisation Cell, for the practical dose of drug each in prescription to be standardized as opposite dose, and by each drug
The efficacy strength of various single effects that has as corresponding drug of opposite dose；
Prescription Effect value determination unit, for the power using the opposite dose of drug each in prescription as corresponding drug attribute
Value, and value the effect of the interaction coefficient combined in prescription between each each effect of drug determines each effect in prescription；
Output unit, if the prescription for input is single, value the effect of output each effect of prescription；If the prescription of input
When being multiple, Prescription Effect trend graph is exported.
Further, the system also includes：Traditional chinese medicine medicament database determination unit；
The Traditional chinese medicine medicament database determination unit, for obtaining the attribute of Traditional chinese medicine medicament and each drug, practical dose, most
Small common dose and maximum common dose, and numeralization processing is carried out to the attribute of the Traditional chinese medicine medicament, establish Traditional chinese medicine medicament number
According to library；
Effect interaction coefficient determination unit includes：
Traditional chinese medicine medicament database effect similarity matrix determining module, for being stored according in the Traditional chinese medicine medicament database
Each drug attribute, determine the similarity between each effect, form Traditional chinese medicine medicament database effect similarity matrix；
Prescription Effect similarity matrix determining module, for according in prescription the effect of each drug, to the traditional Chinese medicine of formation
Object database effect similarity matrix is extracted, and obtains Prescription Effect similarity matrix；
Drug similarity matrix determining module, for the attribute according to drug each in prescription, determine in prescription each drug it
Between similarity, formed drug similarity matrix；
Effect interaction coefficient determining module, for the Prescription Effect similarity matrix and drug similarity according to formation
Matrix determines the interaction coefficient between each each effect of drug in prescription.
Further, Traditional chinese medicine medicament database effect similarity matrix determining module, specifically for passing through the first public affairs
Formula determines the corresponding average pharmacological property value of each effect, average flavour of a drug value and average channel tropism value vector in Traditional chinese medicine medicament database, described
First formula is expressed as：
In formula, VeRepresent the corresponding average pharmacological property value of e kind effects, average flavour of a drug value and average channel tropism value vector, VtIt represents
Pharmacological property, flavour of a drug and the channel tropism vector of t kind drugs, t=1,2 ... T represent t kind drugs in Traditional chinese medicine medicament database, and T is represented
The species number of drug, M in Traditional chinese medicine medicament databaseteRepresent e kind effects of t kind drugs, e=1,2 ..., E, E is drug
Effect species number；
The similarity of two kinds of effects is determined by the second formula, second formula is expressed as：
In formula, wpqRepresent the similarity between pth kind effect and q kind effects, VpRepresent that pth kind effect is corresponding average
Pharmacological property value, average flavour of a drug value and average channel tropism value vector, VqRepresent the corresponding average pharmacological property value of q kind effects, average flavour of a drug value
With average channel tropism value vector；
0 to the value between maximum similarity value is divided to obtain multiple similarity dimensions, each similarity dimensions pair
Answer effect interaction value；
According to the similarity dimensions belonging to the similarity value of two kinds of effects, determine that the effect of two kinds of effects correspond to interacts
Value；
The interaction value according to the effect of two kinds of effects builds Traditional chinese medicine medicament database effect similarity matrix；
The drug similarity matrix determining module specifically for the attribute according to drug each in prescription, is determined in prescription
Similarity between each drug forms drug similarity matrix and includes：
Similarity in prescription between each drug is determined by third formula, the third formula is expressed as：
In formula, SijRepresent the similarity between i-th kind of drug and jth kind drug, vikAnd vjkI-th, two kinds of j is represented respectively
The numeralization of the kth kind pharmacological property of drug, flavour of a drug or channel tropism attribute is as a result, i, j=1,2 ..., n, n represent the kind of drug in prescription
Class number, k=1,2 ..., K, K represent the total number of medicine property of medicine, flavour of a drug and channel tropism attribute.
Further, the Prescription Effect value determination unit determines each effect in prescription specifically for passing through the 4th formula
The effect of value, the 4th formula is expressed as：
In formula, HPThe effect of representing pth kind effect in prescription value, i, j=1,2 ..., n, n represent each medicament categories in prescription
Number, XipRepresent the efficacy strength of pth kind effect of i-th kind of drug, p=1,2 ..., E, q=1,2 ..., E, E represent effect type
Number, XjqRepresent the efficacy strength of q kind effects of jth kind drug,Represent pth kind effect of i-th kind of drug and jth kind medicine
Interaction coefficient between q kind effects of object.
The above-mentioned technical proposal of the present invention has the beneficial effect that：
In said program, by the attribute of each drug in the prescription that gets, determine in prescription between each each effect of drug
Interaction coefficient；The practical dose of drug each in the prescription got is standardized as opposite dose, and by each drug
The efficacy strength of various single effects that has as corresponding drug of opposite dose；The opposite dose of drug each in prescription is made
To correspond to the weights of drug attribute, and the interaction coefficient combined in prescription between each each effect of drug determines each work(in prescription
The effect of effect value.In this way, the opposite dose by determining each drug in prescription, by the practical dose nondimensionalization of drug so that
Each drug is compared under same standard in prescription, and combines influencing each other between each each effect of drug in prescription, really
The effect of determining each effect in prescription value, so as to quantify to parse the Feature Dependence relationship between the medicine element contained in prescription,
The quantitative description for realizing tcm prescription effect and qualitatively forecast analysis.
Description of the drawings
Fig. 1 is the method flow diagram of tcm prescription effect quantitative approach provided in an embodiment of the present invention based on Chinese medicine attribute
One；
Fig. 2 is the method flow diagram of tcm prescription effect quantitative approach provided in an embodiment of the present invention based on Chinese medicine attribute
Two；
Fig. 3 is method flow diagram of the determining prescription provided in an embodiment of the present invention with respect to dose；
Fig. 4 is the structural representation of tcm prescription effect quantitative system provided in an embodiment of the present invention based on Chinese medicine attribute
Figure；
Fig. 5 is the workflow of tcm prescription effect quantitative system provided in an embodiment of the present invention based on Chinese medicine attribute
Figure；
Fig. 6 is that the human-computer interaction of tcm prescription effect quantitative system provided in an embodiment of the present invention based on Chinese medicine attribute is shown
It is intended to.
Specific embodiment
To make the technical problem to be solved in the present invention, technical solution and advantage clearer, below in conjunction with attached drawing and tool
Body embodiment is described in detail.
The present invention has ignored mutual between each efficacy of drugs attribute for existing traditional Prescription Effect quantitative approach
Effect the problem of only obtaining the quantized value of Prescription Effect by practical dose, cause quantized value accuracy rate low, is provided during one kind is based on
The tcm prescription effect quantitative approach and system of medicine attribute.
Embodiment one
As depicted in figs. 1 and 2, a kind of tcm prescription effect quantitative square based on Chinese medicine attribute provided in an embodiment of the present invention
Method, including：
S1：Prescription is obtained, determines that the attribute of each drug and practical dose, the attribute include in prescription：Pharmacological property, flavour of a drug,
Channel tropism and effect；
S2：According to preset Traditional chinese medicine medicament database, the interaction coefficient between each each effect of drug in prescription is determined；
S3：The practical dose of drug each in prescription is standardized as opposite dose, and the opposite dose of each drug is made
The efficacy strength of various single effects having for corresponding drug；
S4：Using the opposite dose of drug each in prescription as the weights of corresponding drug attribute, and combine each drug in prescription
The effect of interaction coefficient between each effect determines each effect in prescription value.
Tcm prescription effect quantitative approach based on Chinese medicine attribute described in the embodiment of the present invention, passes through the prescription got
In each drug attribute, determine the interaction coefficient between each each effect of drug in prescription；By medicine each in the prescription got
The practical dose of object is standardized as opposite dose, and has using the opposite dose of each drug as correspondence drug various single
The efficacy strength of effect；Using the opposite dose of drug each in prescription as the weights of corresponding drug attribute, and combine each in prescription
The effect of interaction coefficient between each effect of drug determines each effect in prescription value.In this way, by determining each medicine in prescription
The opposite dose of object, by the practical dose nondimensionalization of drug so that each drug is compared under same standard in prescription,
And value the effect of influencing each other, determine each effect in prescription in prescription between each each effect of drug is combined, so as to quantify to parse
Feature Dependence relationship between the medicine element contained in prescription, realize tcm prescription effect quantitative description and qualitatively in advance
Survey analysis.
In the embodiment of the present invention, in prescription is determined before the attribute of each drug and practical dose, also need to obtain traditional Chinese medicine
The attribute of object and each drug, practical dose, minimum common dose and maximum common dose, and to the attribute of the Traditional chinese medicine medicament into
Line number value is handled, and establishes Traditional chinese medicine medicament database.
Wherein, the specific steps for establishing Traditional chinese medicine medicament database include：
(attribute includes for acquisition Traditional chinese medicine medicament and drug attribute：Pharmacological property, flavour of a drug, channel tropism and effect), practical dose, most
Small common dose and maximum common dose, by the Attribute decomposition of each drug, for pharmacological property, (pharmacological property includes：It is cold, Great Cold, heat, big
It is heat, temperature, tepor, flat, cool, micro- cool), (flavour of a drug include flavour of a drug：It is sour, bitter, sweet, pungent, salty, flat, puckery, light), channel tropism it is (described to return
Through including：Small intestine, large intestine, liver, lung, three cokes, kidney, stomach, spleen, bladder, courage, the heart, pericardium) and effect (described effect includes：Clearly
Heat Xie Huo, enriches blood, delivers, expelling pathogenic factors from muscles and skin and stomach, lower gas, changes stagnant, removing toxic substances, calms the nerves etc.), and the attribute of the Traditional chinese medicine medicament is carried out
Numeralization, missing values processing, so as to build Traditional chinese medicine medicament database.
Wherein, numeralization processing is carried out to the attribute of the Traditional chinese medicine medicament to include：
Numeralization processing is carried out to the pharmacological property of the Traditional chinese medicine medicament：For example, pharmacological property attribute can be put down into number centered on flat
Value is 0, with tepor, temperature, heat, big heat just, pharmacological property attribute tepor, temperature, heat, big hot numerical value respectively to be turned to 1,2,3,4, with
Micro- cool, cool, cold, Great Cold is negative, and by pharmacological property category slightly cool in nature, cool, cold, Great Cold, numerical value turns to -1, -2, -3, -4 respectively；
Numeralization processing is carried out to the flavour of a drug of the Traditional chinese medicine medicament, channel tropism and effect：The unique flavour of a drug of every herbal medicine are returned
Through will appear as a boolean vector on attribute domain with effect；
When the flavour of a drug of each drug are carried out with numeralization processing：The corresponding flavour of a drug attribute value of each drug is turned to 1, other medicines
Taste attribute value cancellation；
When numeralization processing is carried out to the channel tropism of each drug：The corresponding channel tropism attribute value of each drug is turned to 1, other are returned
Through attribute value cancellation；
When the effect of to each drug, carries out numeralization processing：The effect of each drug is corresponded to attribute value turns to 1, other work(
Imitate attribute value cancellation.
In the embodiment of the present invention, for prescription by taking Guizhi decoction as an example, input prescription each group is (cassia twig, Chinese herbaceous peony, ginger, sweet into drug
Grass and jujube) and practical dose, according to Traditional chinese medicine medicament database, inquire cassia twig in prescription, Chinese herbaceous peony, ginger, Radix Glycyrrhizae and jujube
Attribute, obtain Guizhi decoction-meridian distribution of property and flavor effect table, as shown in table 1：
1 Guizhi decoction of table-meridian distribution of property and flavor effect table
Numeralization processing is carried out to pharmacological property, flavour of a drug, channel tropism and effect of drug each in Guizhi decoction, quantize result such as table 2
(a), table 2 (b), shown in table 2 (c)：
Meridian distribution of property and flavor effect table of table 2 (a) Guizhi decoction-numeralization
| Drug | Property | It is sweet | Acid | It is pungent | It is bitter | Liver | Lung | Kidney | Stomach | Spleen | Bladder | The heart |
| Cassia twig | 2 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
| Ginger | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 |
| Radix Glycyrrhizae | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 |
| Chinese herbaceous peony | -2 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
| Jujube | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 |
Meridian distribution of property and flavor effect table of table 2 (b) Guizhi decoction-numeralization
| Drug | Inducing diaphoresis | It delivers | Analgesic | Preventing or arresting vomiting | Wen Tong | And stomach | Eliminating the phlegm | Sweating |
| Cassia twig | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 |
| Ginger | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| Radix Glycyrrhizae | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Chinese herbaceous peony | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
| Jujube | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Meridian distribution of property and flavor effect table of table 2 (c) Guizhi decoction-numeralization
| Drug | It is supporing yang | Removing toxic substances | Calm the nerves | Blood-nourishing | Expelling pathogenic factors from muscles and skin | Promoting menstruation | QI invigorating | Cough-relieving |
| Cassia twig | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
| Ginger | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
| Radix Glycyrrhizae | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
| Chinese herbaceous peony | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
| Jujube | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 |
In the specific embodiment of aforementioned tcm prescription effect quantitative approach based on Chinese medicine attribute, further, institute
It states and according to preset Traditional chinese medicine medicament database, determines that the interaction coefficient in prescription between each each effect of drug includes：
According to the attribute of each drug stored in the Traditional chinese medicine medicament database, the similarity between each effect, shape are determined
Into Traditional chinese medicine medicament database effect similarity matrix；
According to the effect of each drug, being extracted in prescription to Traditional chinese medicine medicament database effect similarity matrix of formation,
Obtain Prescription Effect similarity matrix；According to the attribute of drug each in prescription, the similarity between each drug, shape in prescription are determined
Into drug similarity matrix；
According to the Prescription Effect similarity matrix of formation and drug similarity matrix, determine in prescription each each effect of drug it
Between interaction coefficient.
It, can will be in Traditional chinese medicine medicament database by the concept of the approach degree provided in fuzzy logic in the embodiment of the present invention
Pharmacological property value, flavour of a drug value and channel tropism value equalization when each effect occurs, obtain the pharmacological property value, flavour of a drug value and channel tropism of each efficacy of drugs
It is worth average vector (abbreviation effect vector), for arbitrary two kinds of effects, method is asked to obtain both work(according to the distance of effect vector
The similarity of effect, so as to form Traditional chinese medicine medicament database effect similarity matrix.Wherein, it is described according to the Traditional chinese medicine medicament data
The attribute of each drug stored in library determines the similarity between each effect, forms Traditional chinese medicine medicament database effect similarity moment
Battle array includes：
According to the attribute of each drug stored in the Traditional chinese medicine medicament database, Traditional chinese medicine medicament data are determined by formula (1)
The corresponding average pharmacological property value of each effect, average flavour of a drug value and average channel tropism value vector, the formula (1) are expressed as in library：
In formula (1), VeRepresent the corresponding average pharmacological property value of e kind effects, average flavour of a drug value and average channel tropism value vector, Vt
Represent pharmacological property, flavour of a drug and the channel tropism vector (abbreviation meridian distribution of property and flavor vector) of t kind drugs, t=1,2 ... T represent Traditional chinese medicine medicament number
According to t kind drugs in library, T represents the species number of drug in Traditional chinese medicine medicament database, MteRepresent e kind effects of t kind drugs,
E=1,2 ..., E, E be drug the effect of species number；
The similarity of arbitrary two kinds of effects is determined by formula (2), the formula (2) is expressed as：
In formula (2), wpqRepresent the similarity between pth kind effect and q kind effects, VpRepresent that pth kind effect is corresponding
Average pharmacological property value, average flavour of a drug value and average channel tropism value vector, VqRepresent the corresponding average pharmacological property value of q kind effects, average medicine
Taste value and average channel tropism value vector；
According to obtained wpq, primarily determine Traditional chinese medicine medicament database effect similarity matrix W=(wpq), wherein, W is pair
Claim, p, q=1,2 ..., E, E represent drug the effect of species number.Due to, each drug in same prescription different efficacies it
Between there is complicated interaction relationship, according to tcm prescription theory, the interaction two-by-two of can be by each drug the effect of
Relationship is generalized into 6 types：Effect is identical, the two-way collaboration of effect, effect unidirectionally cooperate with, effect it is weak inhibit, effect high inhibition and
It is irrelevant, and this 6 kinds of interaction types are marked respectively to obtain 6 effect interaction values, for example, effect is identical
Labeled as 1, effect, unidirectionally collaboration inhibits labeled as 3, effect is weak labeled as 4, effect high inhibition labeled as 2, the two-way collaboration of effect
It is labeled as 5, irrelevant label.
According to tcm prescription theory, the relationship between two kinds of effects is belonged into assigning together for this 6 type and is corresponded to
The effect of interaction value, the value range for making similarity value in Traditional chinese medicine medicament database effect similarity matrix W is 0~5.
Specifically, maximum similarity value is MAX in note Traditional chinese medicine medicament database effect similarity matrix W, Traditional chinese medicine medicament database work(
Numerical value is divided into 6 similarity dimensions, each similarity dimensions according to from 0 to maximum similarity value (MAX) in effect similarity matrix W
Corresponding effect interaction value, according to the similarity dimensions belonging to the similarity value of two kinds of effects, determines two kinds of effects pair
The effect of answering interaction value, and original similarity value is updated with interaction value the effect of obtaining, so as to obtain the 0-5 traditional Chinese medical science
Drug data base effect similarity matrix W=(wpq), wherein, similarity value and the correspondence of effect interaction value are expressed as
Formula (3)：
In the embodiment of the present invention, for example, maximum similarity value MAX=in Traditional chinese medicine medicament database effect similarity matrix W
6.63, prescription is by taking Guizhi decoction as an example, similar to Traditional chinese medicine medicament database effect of formation according in Guizhi decoction the effect of each drug
Degree matrix is extracted, and obtains Guizhi decoction effect similarity matrix, the Guizhi decoction effect similarity matrix primarily determined such as 3 institute of table
Show, the 0-5 Guizhi decoction effect similarity matrixs being updated using effect interaction value are as shown in table 4：
Guizhi decoction effect similarity matrix that table 3 primarily determines
| Inducing diaphoresis | It delivers | Analgesic | Preventing or arresting vomiting | Wen Tong | And stomach | Eliminating the phlegm | Sweating | It is supporing yang | Removing toxic substances | Calm the nerves | Blood-nourishing | Expelling pathogenic factors from muscles and skin | Promoting menstruation | QI invigorating | Cough-relieving | |
| Inducing diaphoresis | 0.00 | 1.06 | 0.53 | 0.80 | 2.43 | 0.99 | 0.92 | 1.75 | 1.65 | 1.79 | 1.54 | 1.82 | 1.38 | 1.28 | 1.34 | 1.24 |
| It delivers | 1.06 | 0.00 | 1.14 | 0.68 | 1.90 | 1.05 | 1.50 | 1.31 | 1.37 | 2.54 | 2.05 | 2.25 | 1.27 | 2.00 | 1.22 | 1.87 |
| Analgesic | 0.53 | 1.14 | 0.00 | 0.74 | 2.39 | 0.71 | 0.90 | 1.77 | 1.41 | 1.79 | 1.34 | 1.56 | 1.38 | 1.09 | 1.15 | 1.26 |
| Preventing or arresting vomiting | 0.80 | 0.68 | 0.74 | 0.00 | 2.27 | 0.58 | 1.25 | 1.68 | 1.36 | 2.14 | 1.71 | 1.81 | 1.19 | 1.54 | 1.01 | 1.57 |
| Wen Tong | 2.43 | 1.90 | 2.39 | 2.27 | 0.00 | 2.35 | 2.71 | 1.11 | 1.95 | 3.65 | 2.83 | 3.07 | 1.87 | 3.20 | 2.09 | 2.96 |
| And stomach | 0.99 | 1.05 | 0.71 | 0.58 | 2.35 | 0.00 | 1.13 | 1.86 | 1.46 | 1.98 | 1.43 | 1.53 | 1.27 | 1.37 | 0.82 | 1.40 |
| Eliminating the phlegm | 0.92 | 1.50 | 0.90 | 1.25 | 2.71 | 1.13 | 0.00 | 2.25 | 2.03 | 1.26 | 1.08 | 1.43 | 1.55 | 0.96 | 1.40 | 0.66 |
| Sweating | 1.75 | 1.31 | 1.77 | 1.68 | 1.11 | 1.86 | 2.25 | 0.00 | 1.30 | 3.32 | 2.67 | 2.92 | 1.84 | 2.76 | 1.81 | 2.64 |
| It is supporing yang | 1.65 | 1.37 | 1.41 | 1.36 | 1.95 | 1.46 | 2.03 | 1.30 | 0.00 | 3.07 | 2.34 | 2.37 | 1.97 | 2.34 | 1.42 | 2.47 |
| Removing toxic substances | 1.79 | 2.54 | 1.79 | 2.14 | 3.65 | 1.98 | 1.26 | 3.32 | 3.07 | 0.00 | 1.16 | 1.41 | 2.15 | 0.93 | 2.28 | 0.83 |
| Calm the nerves | 1.54 | 2.05 | 1.34 | 1.71 | 2.83 | 1.43 | 1.08 | 2.67 | 2.34 | 1.16 | 0.00 | 0.72 | 1.57 | 0.99 | 1.50 | 0.85 |
| Blood-nourishing | 1.82 | 2.25 | 1.56 | 1.81 | 3.07 | 1.53 | 1.43 | 2.92 | 2.37 | 1.41 | 0.72 | 0.00 | 1.74 | 1.19 | 1.50 | 1.21 |
| Expelling pathogenic factors from muscles and skin | 1.38 | 1.27 | 1.38 | 1.19 | 1.87 | 1.27 | 1.55 | 1.84 | 1.97 | 2.15 | 1.57 | 1.74 | 0.00 | 1.82 | 1.19 | 1.58 |
| Promoting menstruation | 1.28 | 2.00 | 1.09 | 1.54 | 3.20 | 1.37 | 0.96 | 2.76 | 2.34 | 0.93 | 0.99 | 1.19 | 1.82 | 0.00 | 1.80 | 0.94 |
| QI invigorating | 1.34 | 1.22 | 1.15 | 1.01 | 2.09 | 0.82 | 1.40 | 1.81 | 1.42 | 2.28 | 1.50 | 1.50 | 1.19 | 1.80 | 0.00 | 1.58 |
| Cough-relieving | 1.24 | 1.87 | 1.26 | 1.57 | 2.96 | 1.40 | 0.66 | 2.64 | 2.47 | 0.83 | 0.85 | 1.21 | 1.58 | 0.94 | 1.58 | 0.00 |
Due to, pharmacological property, flavour of a drug, channel tropism property value be difficult to utterly judge it is true and false, often in [0,1] in various degree
True value occur, therefore, by the meridian distribution of property and flavor vector V of drugi=(vik) be processed into fuzzy set and will more meet reality, wherein, Vi
Represent pharmacological property, flavour of a drug and the channel tropism vector of i-th kind of drug, vikRepresent kth kind pharmacological property, flavour of a drug or the channel tropism attribute of i-th kind of drug
Numeralization as a result, i=1,2 ..., n, n represents the species number of drug in prescription, k=1,2 ..., K, K be each drug pharmacological property,
The total number of flavour of a drug and channel tropism attribute.
4 0-5 Guizhi decoction effect similarity matrixs of table
| Inducing diaphoresis | It delivers | Analgesic | Preventing or arresting vomiting | Wen Tong | And stomach | Eliminating the phlegm | Sweating | It is supporing yang | Removing toxic substances | Calm the nerves | Blood-nourishing | Expelling pathogenic factors from muscles and skin | Promoting menstruation | QI invigorating | Cough-relieving | |
| Inducing diaphoresis | 1 | 2 | 3 | 3 | 0 | 3 | 3 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| It delivers | 2 | 1 | 2 | 3 | 2 | 2 | 2 | 2 | 2 | 0 | 0 | 0 | 2 | 2 | 2 | 2 |
| Analgesic | 3 | 2 | 1 | 3 | 0 | 3 | 3 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| Preventing or arresting vomiting | 3 | 3 | 3 | 1 | 0 | 3 | 2 | 2 | 2 | 0 | 2 | 2 | 2 | 2 | 2 | 2 |
| Wen Tong | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 2 | 2 | 4 | 0 | 4 | 2 | 4 | 0 | 0 |
| And stomach | 3 | 2 | 3 | 3 | 0 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 3 | 2 |
| Eliminating the phlegm | 3 | 2 | 3 | 2 | 0 | 2 | 1 | 0 | 0 | 2 | 2 | 2 | 2 | 3 | 2 | 3 |
| Sweating | 2 | 2 | 2 | 2 | 2 | 2 | 0 | 1 | 2 | 4 | 0 | 0 | 2 | 0 | 2 | 0 |
| It is supporing yang | 2 | 2 | 2 | 2 | 2 | 2 | 0 | 2 | 1 | 4 | 0 | 0 | 2 | 0 | 2 | 0 |
| Removing toxic substances | 2 | 0 | 2 | 0 | 4 | 2 | 2 | 4 | 4 | 1 | 2 | 2 | 0 | 3 | 0 | 3 |
| Calm the nerves | 2 | 0 | 2 | 2 | 0 | 2 | 2 | 0 | 0 | 2 | 1 | 3 | 2 | 3 | 2 | 3 |
| Blood-nourishing | 2 | 0 | 2 | 2 | 4 | 2 | 2 | 0 | 0 | 2 | 3 | 1 | 2 | 2 | 2 | 2 |
| Expelling pathogenic factors from muscles and skin | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 0 | 2 | 2 | 1 | 2 | 2 | 2 |
| Promoting menstruation | 2 | 2 | 2 | 2 | 4 | 2 | 3 | 0 | 0 | 3 | 3 | 2 | 2 | 1 | 2 | 3 |
| QI invigorating | 2 | 2 | 2 | 2 | 0 | 3 | 2 | 2 | 2 | 0 | 2 | 2 | 2 | 2 | 1 | 2 |
| Cough-relieving | 2 | 2 | 2 | 2 | 0 | 2 | 3 | 0 | 0 | 3 | 3 | 2 | 2 | 3 | 2 | 1 |
In the embodiment of the present invention, it can be calculated in prescription by the concept by the approach degree provided in fuzzy logic
Drug similarity matrix.Wherein, it according to the attribute of drug each in prescription, determines the similarity between each drug in prescription, is formed
Drug similarity matrix includes：
Similarity in prescription between each drug is determined by formula (4), the formula (4) is expressed as：
In formula (4), SijRepresent the similarity (approach degree) between i-th kind of drug and jth kind drug, vikAnd vjkTable respectively
Show the numeralization of the kth kind pharmacological property of i-th, j, two kinds of drugs, flavour of a drug or channel tropism attribute as a result, i, j=1,2 ..., n, n represent prescription
The species number of middle drug, k=1,2 ..., K, K represent the total number of medicine property of medicine, flavour of a drug and channel tropism attribute.
In the embodiment of the present invention, prescription is by taking Guizhi decoction as an example, and according to table 2 (a), table 2 (b), table 2 (c) is obtained by formula (4)
Similarity matrix (abbreviation drug similarity matrix) between each drug of Guizhi decoction, as shown in table 5.
In general, the similarity of two kinds of drugs is bigger, and the intensity of interaction is stronger.
The drug similarity matrix of 5 Guizhi decoction of table
| Cassia twig | Radix Glycyrrhizae | Chinese herbaceous peony | Ginger | Jujube | |
| Cassia twig | 1.000 | 0.564 | 0.345 | 0.465 | 0.423 |
| Radix Glycyrrhizae | 0.564 | 1.000 | 0.423 | 0.564 | 0.622 |
| Chinese herbaceous peony | 0.345 | 0.423 | 1.000 | 0.423 | 0.465 |
| Ginger | 0.465 | 0.564 | 0.423 | 1.000 | 0.622 |
| Jujube | 0.423 | 0.622 | 0.465 | 0.622 | 1.000 |
In the embodiment of the present invention, according to obtained Prescription Effect similarity matrix and drug similarity matrix, pass through formula (5)
Calculate the interaction coefficient between each each effect of drug in prescriptionThe formula (5) is expressed as：
In formula (5), wpqRepresent the similarity between pth kind effect and q kind effects, SijRepresent i-th kind of drug and jth
Similarity between kind drug,Represent pth kind effect and the jth kind drug of i-th kind of drug in prescription q kinds effect it
Between interaction coefficient.
In the embodiment of the present invention, the interaction coefficient in Guizhi decoction between each each effect of drug, shape are obtained according to formula (5)
Interaction matrix into Guizhi decoction between each each effect of drug.
In the specific embodiment of aforementioned tcm prescription effect quantitative approach based on Chinese medicine attribute, further, institute
It states and is standardized as including with respect to dose by the practical dose of drug each in prescription：
Dose and maximum common dose are commonly used, and tie according to the minimum of drug each in the prescription of Traditional chinese medicine medicament database purchase
The practical dose of each drug in prescription is closed, the practical dose of drug each in prescription is standardized as opposite medicine by standardizing formula
Amount；
Wherein, standardization formula is：
In formula,X is the opposite dose of drug, and x is the practical dose of drug, and M is medicine
The maximum of object commonly uses dose, and m is that the minimum of drug commonly uses dose.
In the embodiment of the present invention, prescription by taking Guizhi decoction as an example, and by the dosage unit of drug each in prescription be standardized into
" gram " is unit,《The pharmacology of traditional Chinese medical formulae》The formula of middle Guizhi decoction includes：Cassia twig 9g, Chinese herbaceous peony 9g, Radix Glycyrrhizae 6g, ginger 9g, jujube 6g connect
It, drug dose is analyzed and processed, be standardized as the practical dose of drug each in prescription relatively by standardizing formula
Dose is placed on drug dose each in prescription under same standard and is compared, it is contemplated that interacts between efficacy of drugs
The problem of, it can quantify to parse the Feature Dependence relationship between the medicine element that prescription is contained, standardisation process such as Fig. 3 institutes
Show, Guizhi decoction is with respect to shown in medicine calculation result table 6：
The practical dose of 6 Guizhi decoction of table and opposite dose
| Guizhi decoction | Practical dose | With respect to dose |
| Cassia twig | 9g | 186 |
| Ginger | 9g | 10 |
| Radix Glycyrrhizae | 6g | 64.16667 |
| Chinese herbaceous peony | 9g | 30 |
| Jujube | 6g | 6.666667 |
It sorts from big to small with respect to dose to each drug in the Guizhi decoction come is obtained, ranking results are as shown in table 7：
The practical dose of 7 Guizhi decoction of table and opposite dose (sequence)
| Guizhi decoction | Practical dose | With respect to dose |
| Cassia twig | 9g | 186 |
| Radix Glycyrrhizae | 6g | 64.16667 |
| Chinese herbaceous peony | 9g | 30 |
| Ginger | 9g | 10 |
| Jujube | 6g | 6.666667 |
According to table 2 (a), table 2 (b), table 2 (c) can obtain the drug effect of each drug, and each drug with respect to dose XiIt can
The action intensity of i-th kind of drug in prescription is regarded as, so as to be all various single effects that the drug has by its etc.
Efficacy strength is denoted as Xie, XieThe efficacy strength of e kind effects of i-th kind of drug of expression, the drug effect that i-th kind of drug does not have,
Effect intensity value is set as 0, and intensity is as shown in table 8 the effect of each drug in Guizhi decoction：
Intensity the effect of various single effects of each drug in 8 Guizhi decoction of table
The effect of prescription intensity be all drugs for forming prescription institute it is medicative complicated comprehensive, can be according in prescription
Each each effect of drug influences each other, and calculates the effect of prescription is whole value.Specifically, each effect in prescription is determined by formula (6)
The effect of value, the 4th formula is expressed as：
In formula (6), HPThe effect of representing pth kind effect in prescription value, i, j=1,2 ..., n, n represent each drug in prescription
Species number, XipRepresent the efficacy strength of pth kind effect of i-th kind of drug, p=1,2 ..., E, q=1,2 ..., E, E represent effect
Species number, XjqRepresent the efficacy strength of q kind effects of jth kind drug,Represent pth kind effect and jth of i-th kind of drug
Interaction coefficient between q kind effects of kind drug.
In the embodiment of the present invention, prescription is by taking Guizhi decoction as an example, the effect of obtaining each effect in Guizhi decoction according to the 4th formula
Value, as shown in table 9 (a), 9 (b)：
Value the effect of each effect in table 9 (a) Guizhi decoction
| Effect | And stomach | Expelling pathogenic factors from muscles and skin | It delivers | Analgesic | Promoting menstruation | Inducing diaphoresis | Preventing or arresting vomiting | Cough-relieving |
| Effect value | 2083.0 | 2078.1 | 2074.2 | 1787.0 | 1780.3 | 1736.0 | 1710.8 | 1665.5 |
Value the effect of each effect in table 9 (b) Guizhi decoction
| Effect | Eliminating the phlegm | QI invigorating | Sweating | It is supporing yang | Calm the nerves | Wen Tong | Blood-nourishing | Removing toxic substances |
| Effect value | 1639.8 | 1593.1 | 1584.0 | 1584.0 | 1181.5 | 1180.5 | 749.7 | 731.7 |
In the embodiment of the present invention, set about from traditional Chinese medicine prescription cassia twig soup formula, each drug in prescription is extracted, by each drug
Druggability, four generic attribute of flavour of a drug, channel tropism and effect are decomposed respectively, and to Guizhi decoction the effect of carries out quantitative calculating, and result meets
The effect of traditional Chinese medical science is to Guizhi decoction attribute recognizes.The present invention constructs drug similarity moment and effect similarity matrix, and prescription
In the practical dose of each drug be standardized, calculate the opposite dose of each drug, drug each in prescription be placed on same
It is compared under standard, and takes into account the problem of interacting between each efficacy of drugs, it is preliminary to realize quantifying for traditional Chinese medical science effect
Description and qualitatively forecast analysis open a new thinking for tcm prescription drug and efficacy of drugs quantitative study, are applicable in
Prediction scheme, clinical manifestation primary and secondary evaluation scheme in prescription idicatio etc. advance the paces of TCM Modernization, have weight
The meaning wanted.
Embodiment two
The present invention also provides a kind of specific embodiment of tcm prescription effect quantitative system based on Chinese medicine attribute, due to
Tcm prescription effect quantitative system provided by the invention based on Chinese medicine attribute and the aforementioned tcm prescription work(based on Chinese medicine attribute
The specific embodiment for imitating quantitative approach is corresponding, and being somebody's turn to do tcm prescription effect quantitative system based on Chinese medicine attribute can be by holding
Process step in row above method specific embodiment achieves the object of the present invention, therefore in the above-mentioned attribute based on Chinese medicine
The explanation in Prescription Effect quantitative approach specific embodiment is cured, is also applied for provided by the invention based on Chinese medicine attribute
The specific embodiment of tcm prescription effect quantitative system will not be described in great detail in the specific embodiment below the present invention.
As shown in figure 4, the embodiment of the present invention also provides a kind of tcm prescription effect quantitative system based on Chinese medicine attribute,
It is characterized in that, including：
Input unit, for inputting prescription information, the prescription information includes：The composition drug of prescription and the reality of each drug
Border dose；
Drug attribute determining unit, for determining the attribute of each drug in prescription, the attribute includes：Pharmacological property, is returned at flavour of a drug
Through and effect；
Effect interaction coefficient determination unit, for according to preset Traditional chinese medicine medicament database, determining each medicine in prescription
Interaction coefficient between each effect of object；
Standardisation Cell, for the practical dose of drug each in prescription to be standardized as opposite dose, and by each drug
The efficacy strength of various single effects that has as corresponding drug of opposite dose；
Prescription Effect value determination unit, for the power using the opposite dose of drug each in prescription as corresponding drug attribute
Value, and value the effect of the interaction coefficient combined in prescription between each each effect of drug determines each effect in prescription；
Output unit, if the prescription for input is single, value the effect of output each effect of prescription；If the prescription of input
When being multiple, Prescription Effect trend graph is exported.
In the embodiment of the present invention, according to tcm prescription effect quantitative approach, tcm prescription effect quantitative system is designed, is such as schemed
Shown in 5, by tcm prescription effect quantitative system, the effect of convenient for analyzing single and multiple prescriptions, according to recipe drug information
Tendency and treatment time reflect user's medicine law.The embodiment of the present invention is tcm prescription drug and efficacy of drugs quantitative study
A new thinking is opened, prediction scheme, clinical manifestation primary and secondary evaluation scheme suitable for prescription idicatio etc., in advancing
The paces of medicine modernization.
In the embodiment of the present invention, specifically, by user (for example, doctor or patient) in tcm prescription effect quantitative system
(prescription information includes middle input prescription information：Form the practical dose of drug and each drug), tcm prescription effect quantitative system
Exported according to the value tcm prescription effect quantitative approach calculates each effect of the prescription the effect of and in the form of visualization interface to
User, convenient for customer analysis is single and the effect of multiple prescriptions, is illustrated in figure 6 the man-machine friendship of tcm prescription effect quantitative system
Mutual schematic diagram, when user inputs single prescription, value the effect of output each effect of prescription, can when user inquires multiple prescriptions
To form the Prescription Effect trend graph of user's medication, prescription drug information tendency and treatment time are inquired convenient for user, is reflected
User's medicine law.
Further, the system also includes：Traditional chinese medicine medicament database determination unit；
The Traditional chinese medicine medicament database determination unit, for obtaining the attribute of Traditional chinese medicine medicament and each drug, practical dose, most
Small common dose and maximum common dose, and numeralization processing is carried out to the attribute of the Traditional chinese medicine medicament, establish Traditional chinese medicine medicament number
According to library；
Effect interaction coefficient determination unit includes：
Traditional chinese medicine medicament database effect similarity matrix determining module, for being stored according in the Traditional chinese medicine medicament database
Each drug attribute, determine the similarity between each effect, form Traditional chinese medicine medicament database effect similarity matrix；
Prescription Effect similarity matrix determining module, for according in prescription the effect of each drug, to the traditional Chinese medicine of formation
Object database effect similarity matrix is extracted, and obtains Prescription Effect similarity matrix；
Drug similarity matrix determining module, for the attribute according to drug each in prescription, determine in prescription each drug it
Between similarity, formed drug similarity matrix；
Effect interaction coefficient determining module, for the Prescription Effect similarity matrix and drug similarity according to formation
Matrix determines the interaction coefficient between each each effect of drug in prescription.
Further, Traditional chinese medicine medicament database effect similarity matrix determining module, specifically for passing through the first public affairs
Formula determines the corresponding average pharmacological property value of each effect, average flavour of a drug value and average channel tropism value vector in Traditional chinese medicine medicament database, described
First formula is expressed as：
In formula, VeRepresent the corresponding average pharmacological property value of e kind effects, average flavour of a drug value and average channel tropism value vector, VtIt represents
Pharmacological property, flavour of a drug and the channel tropism vector of t kind drugs, t=1,2 ... T represent t kind drugs in Traditional chinese medicine medicament database, and T is represented
The species number of drug, M in Traditional chinese medicine medicament databaseteRepresent e kind effects of t kind drugs, e=1,2 ..., E, E is drug
Effect species number；
The similarity of two kinds of effects is determined by the second formula, second formula is expressed as：
In formula, wpqRepresent the similarity between pth kind effect and q kind effects, VpRepresent that pth kind effect is corresponding average
Pharmacological property value, average flavour of a drug value and average channel tropism value vector, VqRepresent the corresponding average pharmacological property value of q kind effects, average flavour of a drug value
With average channel tropism value vector；
0 to the value between maximum similarity value is divided to obtain multiple similarity dimensions, each similarity dimensions pair
Answer effect interaction value；
According to the similarity dimensions belonging to the similarity value of two kinds of effects, determine that the effect of two kinds of effects correspond to interacts
Value；
The interaction value according to the effect of two kinds of effects builds Traditional chinese medicine medicament database effect similarity matrix；
The drug similarity matrix determining module specifically for the attribute according to drug each in prescription, is determined in prescription
Similarity between each drug forms drug similarity matrix and includes：
Similarity in prescription between each drug is determined by third formula, the third formula is expressed as：
In formula, SijRepresent the similarity between i-th kind of drug and jth kind drug, vikAnd vjkI-th, two kinds of j is represented respectively
The numeralization of the kth kind pharmacological property of drug, flavour of a drug or channel tropism attribute is as a result, i, j=1,2 ..., n, n represent the kind of drug in prescription
Class number, k=1,2 ..., K, K represent the total number of medicine property of medicine, flavour of a drug and channel tropism attribute.
Further, the Prescription Effect value determination unit determines each effect in prescription specifically for passing through the 4th formula
The effect of value, the 4th formula is expressed as：
In formula, HPThe effect of representing pth kind effect in prescription value, i, j=1,2 ..., n, n represent each medicament categories in prescription
Number, XipRepresent the efficacy strength of pth kind effect of i-th kind of drug, p=1,2 ..., E, q=1,2 ..., E, E represent effect type
Number, XjqRepresent the efficacy strength of q kind effects of jth kind drug,Represent pth kind effect of i-th kind of drug and jth kind medicine
Interaction coefficient between q kind effects of object.
The above is the preferred embodiment of the present invention, it is noted that for those skilled in the art
For, without departing from the principles of the present invention, several improvements and modifications can also be made, these improvements and modifications
It should be regarded as protection scope of the present invention.
Claims (2)
1. a kind of tcm prescription effect quantitative approach based on Chinese medicine attribute, which is characterized in that including：
Prescription is obtained, determines that the attribute of each drug and practical dose, the attribute include in prescription：Pharmacological property, flavour of a drug, channel tropism and work(
Effect；
According to preset Traditional chinese medicine medicament database, the interaction coefficient between each each effect of drug in prescription is determined；
The practical dose of drug each in prescription is standardized as opposite dose, and using the opposite dose of each drug as corresponding medicine
The efficacy strength of various single effects that object has；
According to the interaction system between each effect of drug each in the efficacy strength and prescription of the single effect of each drug in prescription
The effect of counting, determining each effect in prescription value；
Wherein, the acquisition prescription determines before the attribute of each drug and practical dose to include in prescription：
It obtains the attribute of Traditional chinese medicine medicament and each drug, practical dose, minimum common dose and maximum commonly uses dose, and in described
The attribute of medical object carries out numeralization processing, establishes Traditional chinese medicine medicament database；
It is described according to preset Traditional chinese medicine medicament database, determine the interaction coefficient packet between each each effect of drug in prescription
It includes：
According to the attribute of each drug stored in the Traditional chinese medicine medicament database, the similarity between each effect is determined, in formation
Cure drug data base effect similarity matrix；
According to the effect of each drug, extracting, obtain to Traditional chinese medicine medicament database effect similarity matrix of formation in prescription
Prescription Effect similarity matrix；
According to the attribute of drug each in prescription, the similarity between each drug in prescription is determined, form drug similarity matrix；
According to the Prescription Effect similarity matrix of formation and drug similarity matrix, determine in prescription between each each effect of drug
Interaction coefficient；
Wherein, the attribute of each drug stored in the Traditional chinese medicine medicament database according to foundation is determined between each effect of drug
Similarity, formed Traditional chinese medicine medicament database effect similarity matrix include：
The corresponding average pharmacological property value of each effect, average flavour of a drug value in Traditional chinese medicine medicament database are determined by the first formula and averagely returned
Through value vector, first formula is expressed as：
In formula, VeRepresent the corresponding average pharmacological property value of e kind effects, average flavour of a drug value and average channel tropism value vector, VtRepresent t
Pharmacological property, flavour of a drug and the channel tropism vector of kind drug, t=1,2 ... T represent t kind drugs in Traditional chinese medicine medicament database, and T represents the traditional Chinese medical science
The species number of drug, M in drug data baseteE kind effects of t kind drugs are represented, the effect of e=1,2 ..., E, E is drug
Species number；
The similarity of two kinds of effects is determined by the second formula, second formula is expressed as：
In formula, wpqRepresent the similarity between pth kind effect and q kind effects, VpRepresent the corresponding average pharmacological property of pth kind effect
Value, average flavour of a drug value and average channel tropism value vector, VqRepresent the corresponding average pharmacological property value of q kind effects, average flavour of a drug value peace
Equal channel tropism value vector；
0 to the value between maximum similarity value is divided to obtain multiple similarity dimensions, each similarity dimensions correspond to one
A effect interaction value；
According to the similarity dimensions belonging to the similarity value of two kinds of effects, the effect of two kinds of effects correspond to interaction value is determined；
The interaction value according to the effect of two kinds of effects builds Traditional chinese medicine medicament database effect similarity matrix；
Wherein, the attribute according to drug each in prescription determines the similarity between each drug in prescription, and it is similar to form drug
Degree matrix includes：
Similarity in prescription between each drug is determined by third formula, the third formula is expressed as：
In formula, SijRepresent the similarity between i-th kind of drug and jth kind drug, vikAnd vjkI-th, two kinds of drugs of j are represented respectively
Kth kind pharmacological property, flavour of a drug or channel tropism attribute numeralization as a result, i, j=1,2 ..., n, n represent the species number of drug in prescription,
K=1,2 ..., K, K represent the total number of medicine property of medicine, flavour of a drug and channel tropism attribute；
Wherein, the practical dose by drug each in prescription is standardized as including with respect to dose：
Dose and maximum common dose, and combination side are commonly used according to the minimum of drug each in the prescription of Traditional chinese medicine medicament database purchase
The practical dose of drug each in prescription is standardized as opposite dose by the practical dose of each drug in agent by standardizing formula；
Wherein, standardization formula is：
In formula,X is the opposite dose of drug, and x is the practical dose of drug, and M is drug
The common dose of maximum, m are that the minimum of drug commonly uses dose；
Wherein, the phase according between each effect of drug each in the efficacy strength and prescription of the single effect of each drug in prescription
Interaction factor, the effect of determining each effect in prescription value include：
The effect of determining each effect in prescription by the 4th formula value, the 4th formula are expressed as：
In formula, HPThe effect of representing pth kind effect in prescription value, i, j=1,2 ..., n, n represent each medicament categories number in prescription,
XipRepresenting the efficacy strength of pth kind effect of i-th kind of drug, p=1,2 ..., E, q=1,2 ..., E, E represent effect species number,
XjqRepresent the efficacy strength of q kind effects of jth kind drug,Represent pth kind effect of i-th kind of drug and jth kind drug
Interaction coefficient between q kind effects；
Wherein,wpqRepresent the similarity between pth kind effect and q kind effects.
2. a kind of tcm prescription effect quantitative system based on Chinese medicine attribute, which is characterized in that including：
Input unit, for inputting prescription information, the prescription information includes：The composition drug of prescription and the practical medicine of each drug
Amount；
Drug attribute determining unit, for determining the attribute of each drug in prescription, the attribute includes：Pharmacological property, flavour of a drug, channel tropism and
Effect；
Effect interaction coefficient determination unit, for according to preset Traditional chinese medicine medicament database, determining that each drug is each in prescription
Interaction coefficient between effect；
Standardisation Cell, for the practical dose of drug each in prescription to be standardized as opposite dose, and by the phase of each drug
The efficacy strength of various single effects having to dose as corresponding drug；
Prescription Effect value determination unit, for according to each drug in the efficacy strength and prescription of the single effect of each drug in prescription
Interaction coefficient between each effect, the effect of determining each effect in prescription value；
Output unit, if the prescription for input is single, value the effect of output each effect of prescription；If the prescription of input is more
When a, Prescription Effect trend graph is exported；
Wherein, the system also includes：Traditional chinese medicine medicament database determination unit；
The Traditional chinese medicine medicament database determination unit, for obtaining the attribute of Traditional chinese medicine medicament and each drug, practical dose, minimum often
Dosage and maximum common dose, and numeralization processing is carried out to the attribute of the Traditional chinese medicine medicament, establish Traditional chinese medicine medicament database；
Effect interaction coefficient determination unit includes：
Traditional chinese medicine medicament database effect similarity matrix determining module, for each according to being stored in the Traditional chinese medicine medicament database
The attribute of drug determines the similarity between each effect, forms Traditional chinese medicine medicament database effect similarity matrix；
Prescription Effect similarity matrix determining module, for according in prescription the effect of each drug, to the Traditional chinese medicine medicament number of formation
It is extracted according to library effect similarity matrix, obtains Prescription Effect similarity matrix；
Drug similarity matrix determining module for the attribute according to drug each in prescription, is determined in prescription between each drug
Similarity forms drug similarity matrix；
Effect interaction coefficient determining module, for the Prescription Effect similarity matrix and drug similarity moment according to formation
Battle array, determines the interaction coefficient between each each effect of drug in prescription；
Wherein, Traditional chinese medicine medicament database effect similarity matrix determining module, specifically for passing through during the first formula determines
Cure the corresponding average pharmacological property value of each effect in drug data base, average flavour of a drug value and average channel tropism value vector, first formula
It is expressed as：
In formula, VeRepresent the corresponding average pharmacological property value of e kind effects, average flavour of a drug value and average channel tropism value vector, VtRepresent t
Pharmacological property, flavour of a drug and the channel tropism vector of kind drug, t=1,2 ... T represent t kind drugs in Traditional chinese medicine medicament database, and T represents the traditional Chinese medical science
The species number of drug, M in drug data baseteE kind effects of t kind drugs are represented, the effect of e=1,2 ..., E, E is drug
Species number；
The similarity of two kinds of effects is determined by the second formula, second formula is expressed as：
In formula, wpqRepresent the similarity between pth kind effect and q kind effects, VpRepresent the corresponding average pharmacological property of pth kind effect
Value, average flavour of a drug value and average channel tropism value vector, VqRepresent the corresponding average pharmacological property value of q kind effects, average flavour of a drug value peace
Equal channel tropism value vector；
0 to the value between maximum similarity value is divided to obtain multiple similarity dimensions, each similarity dimensions correspond to one
A effect interaction value；
According to the similarity dimensions belonging to the similarity value of two kinds of effects, the effect of two kinds of effects correspond to interaction value is determined；
The interaction value according to the effect of two kinds of effects builds Traditional chinese medicine medicament database effect similarity matrix；
The drug similarity matrix determining module specifically for the attribute according to drug each in prescription, determines each medicine in prescription
Similarity between object forms drug similarity matrix and includes：
Similarity in prescription between each drug is determined by third formula, the third formula is expressed as：
In formula, SijRepresent the similarity between i-th kind of drug and jth kind drug, vikAnd vjkI-th, two kinds of drugs of j are represented respectively
Kth kind pharmacological property, flavour of a drug or channel tropism attribute numeralization as a result, i, j=1,2 ..., n, n represent the species number of drug in prescription,
K=1,2 ..., K, K represent the total number of medicine property of medicine, flavour of a drug and channel tropism attribute；
Wherein, the Prescription Effect value determination unit, specifically for passing through the effect of the 4th formula determines each effect in prescription value,
4th formula is expressed as：
In formula, HPThe effect of representing pth kind effect in prescription value, i, j=1,2 ..., n, n represent each medicament categories number in prescription,
XipRepresenting the efficacy strength of pth kind effect of i-th kind of drug, p=1,2 ..., E, q=1,2 ..., E, E represent effect species number,
XjqRepresent the efficacy strength of q kind effects of jth kind drug,Represent pth kind effect of i-th kind of drug and jth kind drug
Interaction coefficient between q kind effects；
Wherein,wpqRepresent the similarity between pth kind effect and q kind effects.
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| CN106778080A (en) * | 2016-11-23 | 2017-05-31 | 小红象医疗科技有限公司 | A kind of Chinese medicinal formulae analysis method and the system for realizing the method |
| CN107945845A (en) * | 2017-11-09 | 2018-04-20 | 西安天巳生生物科技有限公司 | Medicine property of medicine detection and quantization method based on channel tropism effect |
| CN109346180B (en) * | 2018-08-03 | 2022-04-01 | 电子科技大学 | Traditional Chinese medicine prescription monarch, minister, assistant and guide training identification method and system |
| CN109637672B (en) * | 2018-11-28 | 2023-11-07 | 北京工业大学 | Prescription similarity calculation method based on medicine availability |
| CN113470779B (en) * | 2021-09-03 | 2021-11-26 | 壹药网科技(上海)股份有限公司 | Medicine category identification method and system |
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