CN105534917A - Albendazole dry suspension and preparation method thereof - Google Patents
Albendazole dry suspension and preparation method thereof Download PDFInfo
- Publication number
- CN105534917A CN105534917A CN201610037904.0A CN201610037904A CN105534917A CN 105534917 A CN105534917 A CN 105534917A CN 201610037904 A CN201610037904 A CN 201610037904A CN 105534917 A CN105534917 A CN 105534917A
- Authority
- CN
- China
- Prior art keywords
- albendazole
- dry suspension
- solvent
- adjuvant
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses an albendazole dry suspension and a preparation method thereof, and belongs to the field of veterinary medicine preparations. The albendazole dry suspension consists of a suspending aid, a solvent, and auxiliary materials. The albendazole dry suspension has the characteristics of simple preparation method, high sedimentation ratio, high medicinal content uniformity and the like, and can be easily accepted by patients.
Description
Technical field
The invention belongs to field of veterinary medicine preparation, be specifically related to a kind of albendazole dry suspension and preparation method thereof.
Background technology
Albendazole albendazole is the broad-spectrum de-worming medicine of a high-efficiency low-toxicity, and albendazole is clinical can be used for ascarifuge, pinworm, cestode, whipworm, ancylostome, excrement strongylid etc., because its Clinical practice anthelminthic effect is good, is used widely.
Albendazole is insoluble in water, not by water-soluble rear use, affects the absorption after its use and convenience, brings restriction to its application.
Summary of the invention
In order to solve the water-fast problem of albendazole preparation, the invention provides a kind of albendazole dry suspension, solving albendazole preparation water insoluble, not by the technical problem of drinking water administration.The present invention program is specific as follows:
A kind of albendazole dry suspension, is made up of albendazole, suspending agent, solvent, adjuvant, and described solvent is polyvinylpyrrolidone, dimethyl formamide, ethanol, glycerol or its combination.
Further, described suspending agent is carbomer, gummi arabicum pulveratum, tragacanth, sodium carboxymethyl cellulose, hydroxy propyl cellulose, sodium alginate, microcrystalline Cellulose or its compositions.
Further, described adjuvant is lactose, mannitol, starch, xylitol, maltose alcohol, starch milk saccharide complex, sorbitol or its compositions.
Further, the composition of described albendazole dry suspension consists of: precentagewise is calculated, and albendazole is 2 ~ 10%, suspending agent 1 ~ 10%, solvent 5 ~ 20%, surplus are adjuvant.
Another object of the present invention is to provide a kind of preparation method of albendazole dry suspension.In order to realize this object, the present invention is achieved by the following technical solutions:
Take the albendazole of recipe quantity, add the solvent of recipe quantity, stir, albendazole is dissolved completely, obtains settled solution; In solution, successively add suspensoid, adjuvant, stir, mix homogeneously, sieves, dry, again sieves and get final product.
Beneficial effect of the present invention
The invention provides a kind of albendazole dry suspension and preparation method thereof, solve albendazole and be insoluble in water, not by the defect of water-soluble rear use, product sedimentation volume ratio is high, medicament contg homogeneity is good.Preparation method provided by the invention is simple, is easy to realize.
Detailed description of the invention
Embodiment 1: albendazole dry suspension and preparation method thereof
One, prescription: albendazole 2g, sodium carboxymethyl cellulose 1g, polyvinylpyrrolidone 5ml, starch milk saccharide complex polishing are to full dose.
Two, preparation method: the albendazole taking recipe quantity, adds the solvent of recipe quantity, stirs, and albendazole is dissolved completely, obtains settled solution; In solution, successively add suspensoid, adjuvant, stir, mix homogeneously, sieves, dry, again sieves and get final product.
Embodiment 2: albendazole dry suspension and preparation method thereof
One, prescription: albendazole 10g, gummi arabicum pulveratum 10g, dimethyl formamide 20ml, lactose polishing are to full dose.
Two, preparation method: the albendazole taking recipe quantity, adds the solvent of recipe quantity, stirs, and albendazole is dissolved completely, obtains settled solution; In solution, successively add suspensoid, adjuvant, stir, mix homogeneously, sieves, dry, again sieves and get final product.
Embodiment 3: albendazole dry suspension and preparation method thereof
One, prescription: mixture (ethanol: the glycerol=7:3) 15ml of mixture (sodium alginate: microcrystalline Cellulose=2:8) 8g, ethanol and the glycerol of albendazole 6g, sodium alginate and microcrystalline Cellulose, mannitol polishing are to full dose.
Two, preparation method: the albendazole taking recipe quantity, adds the solvent of recipe quantity, stirs, and albendazole is dissolved completely, obtains settled solution; In solution, successively add suspensoid, adjuvant, stir, mix homogeneously, sieves, dry, again sieves and get final product.
Test example: be albendazole dry suspension product homogeneity and sedimentation volume ratio test below
Experimental agents: albendazole dry suspension prepared by embodiment 1 ~ 3.
Experimental technique: homogeneity and sedimentation volume ratio carry out according to " Chinese veterinary pharmacopoeia " version two in 2010.
Experimental result: see the following form 1:
Table 1 albendazole dry suspension character and sedimentation volume ratio result
| Laboratory sample | Homogeneity | Sedimentation volume ratio |
| Embodiment 1 | Qualified | 0.91 |
| Embodiment 2 | Qualified | 0.95 |
| Embodiment 3 | Qualified | 0.93 |
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (5)
1. an albendazole dry suspension, is made up of albendazole, suspending agent, solvent, adjuvant, it is characterized in that, described solvent is polyvinylpyrrolidone, dimethyl formamide, ethanol, glycerol or its combination.
2. albendazole dry suspension according to claim 1, is characterized in that, described suspending agent is carbomer, gummi arabicum pulveratum, tragacanth, sodium carboxymethyl cellulose, hydroxy propyl cellulose, sodium alginate, microcrystalline Cellulose or its compositions.
3. albendazole dry suspension according to claim 1, is characterized in that, described adjuvant is lactose, mannitol, starch, xylitol, maltose alcohol, starch milk saccharide complex, sorbitol or its compositions.
4. the albendazole dry suspension according to any one of claims 1 to 3, is characterized in that, described albendazole is 2 ~ 10%, suspending agent 1 ~ 10%, solvent 5 ~ 20%, surplus are adjuvant.
5. a preparation method for albendazole dry suspension, is characterized in that, takes the albendazole of recipe quantity, adds the solvent of recipe quantity, stirs, and albendazole is dissolved completely, obtains settled solution; In solution, successively add suspensoid, adjuvant, stir, mix homogeneously, sieves, dry, again sieves and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610037904.0A CN105534917A (en) | 2016-01-21 | 2016-01-21 | Albendazole dry suspension and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610037904.0A CN105534917A (en) | 2016-01-21 | 2016-01-21 | Albendazole dry suspension and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105534917A true CN105534917A (en) | 2016-05-04 |
Family
ID=55814851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610037904.0A Pending CN105534917A (en) | 2016-01-21 | 2016-01-21 | Albendazole dry suspension and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105534917A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106377505A (en) * | 2016-10-17 | 2017-02-08 | 朱隆娅 | Mebendazole dry suspension |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1215590A (en) * | 1998-07-24 | 1999-05-05 | 武汉第四制药厂 | Albendazole suspension for expelling and controlling parasite in livestock, and preparing process thereof |
| CN103800354A (en) * | 2013-12-24 | 2014-05-21 | 沈阳伟嘉牧业技术有限公司 | Compound albendazole dry suspension and preparation method thereof |
| CN104688683A (en) * | 2015-03-04 | 2015-06-10 | 西北农林科技大学 | Albendazole suspension and preparation method thereof |
-
2016
- 2016-01-21 CN CN201610037904.0A patent/CN105534917A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1215590A (en) * | 1998-07-24 | 1999-05-05 | 武汉第四制药厂 | Albendazole suspension for expelling and controlling parasite in livestock, and preparing process thereof |
| CN103800354A (en) * | 2013-12-24 | 2014-05-21 | 沈阳伟嘉牧业技术有限公司 | Compound albendazole dry suspension and preparation method thereof |
| CN104688683A (en) * | 2015-03-04 | 2015-06-10 | 西北农林科技大学 | Albendazole suspension and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 蔡进忠等: "阿苯达唑干混悬剂驱除绵羊线虫的效力与安全性试验", 《青海畜牧兽医杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106377505A (en) * | 2016-10-17 | 2017-02-08 | 朱隆娅 | Mebendazole dry suspension |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2020203720B2 (en) | Combination product for the prevention of sexually transmitted infections | |
| CN104490841B (en) | A kind of Apixaban tablet and preparation method thereof | |
| CN103768063B (en) | A kind of moxifloxacin hydrochloride medicinal composition and preparation method thereof | |
| CN102579393A (en) | Solid composition for improving content uniformity and dissolution rate of imidafenacin | |
| CN105534917A (en) | Albendazole dry suspension and preparation method thereof | |
| CN102846570B (en) | Cefditoren pivoxil composition tablets and preparation method thereof | |
| CN105708804A (en) | Decoquinate dry suspension and preparation method thereof | |
| CN105168172A (en) | Erlotinib hydrochloride tablet with improved dissolution rate and stability and preparation method thereof | |
| CN103893107B (en) | Sertaconazole vaginal expansion plug and preparation method thereof and detection method | |
| CN106265489A (en) | A kind of gel preparation containing dapsone and preparation method thereof | |
| CN107625779A (en) | A kind of pharmaceutical preparation, kit for being used to suppress PRRS virus duplication | |
| CN103520106A (en) | Salbutamol sulphate inhalation aerosol and preparation method thereof | |
| CN105919960A (en) | Roxithromycin dispersible tablets and preparation method thereof | |
| WO2021258590A1 (en) | APPLICATION OF β-GLUCAN AS ADHESIVE IN PREPARATION OF TABLET OR GRANULE | |
| CN106580899B (en) | Method for preparing imidafenacin tablets | |
| KR100358081B1 (en) | Steroid anti-inflammatory agent for treatment of stomatitis | |
| CN102485217B (en) | Letrozole tablet with high dissolubility and preparation method thereof | |
| CN109330985A (en) | A kind of vitamin C vaginal tablets and preparation method thereof | |
| CN102366415A (en) | Mice lavage praziquantel suspension and preparation method thereof | |
| CN110721171A (en) | Improved vibration source sheet and preparation method thereof | |
| CN106692062A (en) | Benzimidazole medicine dispersion system and preparation method thereof | |
| CN106102717A (en) | For treating the topical anti-fungal composition of onychomycosis | |
| CN103494896B (en) | Cnidium monnieri and rheum officinale vaginal dilation suppository as well as preparation method and detection method thereof | |
| CN105560248A (en) | Pharmaceutical composition for treating fungal infection and preparing method and application thereof | |
| CN105412018A (en) | Enramycin dry suspension and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160504 |