CN105534713A - Prescription-applied drug 3D printing system and method - Google Patents
Prescription-applied drug 3D printing system and method Download PDFInfo
- Publication number
- CN105534713A CN105534713A CN201610053263.8A CN201610053263A CN105534713A CN 105534713 A CN105534713 A CN 105534713A CN 201610053263 A CN201610053263 A CN 201610053263A CN 105534713 A CN105534713 A CN 105534713A
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical preparation
- prescription
- prints
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F3/00—Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
- G06F3/12—Digital output to print unit, e.g. line printer, chain printer
- G06F3/1293—Printer information exchange with computer
Landscapes
- Engineering & Computer Science (AREA)
- Theoretical Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Human Computer Interaction (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention discloses a prescription-applied drug 3D printing system and method. The system comprises a printing material preparation module, a drug preparation 3D printing manufacturing module, a drug preparation rapid detecting and quality controlling module and a drug preparation rapid packaging module. The prescription-applied drug 3D printing system integrates 3D printing software and hardware developing, material (such as chemical drugs, biological drugs, traditional Chinese medicine extracts and adhesives) printing, drug preparation sterilizing and rapid detecting and packaging into a whole and can reduce the preparation cost of the drugs and the storage cost of a hospital; according to a drug preparation, the drug dosage form and dosage which are suitable for a patient can be customized according to the constitution, disease syndromes and demands of the patient, individual dosage and precise treatment are achieved, therefore, the maximum treatment effect of the drug preparation can be achieved, and the toxic and side effects of the drugs can be reduced to be minimum.
Description
Technical field
The present invention relates to pharmaceutical preparations technology field, be specially the 3D being suitable for chemical drugs, biological medicament and Chinese medicine and print prescription dispenser system and method.
Background technology
At present, the chemical drugs that hospital uses, biological medicament, Chinese patent medicine preparation all adopt batch production, and the therapeutic dose produced, dosage form are comparatively single, not customized for patient, lacking individuality feature.And can exist for the Chinese herbal medicine that patient is customized storage not easily, decoct trouble, the shortcoming such as mouthfeel is bad.
It is a kind of rapid shaping technique that 3D prints, and has the features such as flexible, accurate, quick.Printed by 3D, according to patient individual difference, dosage form can be selected flexibly, accurate control dose, and realize printing speed, thus realize Personalized Drug Administration and precisely treatment.
Chinese patent 201510306998.2 has set forth a kind of manufacture method being exclusively used in Chinese medicine or medicated diet printed based on 3D, but lacking control environment microorganism and medicine detection etc. ensures the standard compliant key link of medicine, needs perfect further.
Summary of the invention
For solving the above problems, the object of the present invention is to provide a kind of 3D to print prescription dispenser system, its 3D being suitable for chemical drugs, biological medicament and Chinese medicine prints, and can ensure to print gained medicine conformance with standard.
Another object of the present invention is to provide a kind of 3D to print prescription application method.
For achieving the above object, the present invention adopts following technical scheme: a kind of 3D prints prescription dispenser system, it is characterized in that comprising:
Print material and prepare module: according to different printing material medicine being made Powdered, graininess or the liquid state being suitable for that multi-pharmaceutics and 3D print of physicochemical property, and print material and meet medicinal standard;
Pharmaceutical preparation 3D prints manufacturing module: comprise 3D printer and pharmaceutical preparation 3D print control system, and 3D printer prints pharmaceutical preparation according to 3DP principle, and whole print procedure is in being full of N
2carry out in the environment of protection gas, by 3D print control system accurately control 3D print the dosage of pharmaceutical preparation and dosage form;
Pharmaceutical preparation detects and quality control module fast: the medicament contg, microorganism limitation etc. that 3D are printed to pharmaceutical preparation detect fast;
Pharmaceutical preparation fast package module: printed by 3D and fast package is carried out to pharmaceutical preparation, and packaging shows drug information.
The described printing material medicine prepared in module is chemical drugs, biological medicament or Chinese medicine.
Described 3D printer prints pharmaceutical preparation according to 3DP principle, and technique is: after last layer bonding, moulding cylinder declines a distance, to rise a height, release some printing materials, and shifted onto moulding cylinder by powder-laying roller, pave and be compacted for powder cylinder; Shower nozzle 3D print control system control under, by next construction section formed data selectively jet binder build aspect; During powder-laying roller paving powder, unnecessary printing material is collected by powder collection device; So powder feeding again and again, paving powder and jet binder, finally complete the bonding of a three-dimensional powder body.
Described 3D printer is equipped with multiinjector.
Described pharmaceutical preparation, in form, can be solid or semi-solid preparation; In dosage form, can be tablet, pill, granule, capsule or suppository; In medicine control, can be controlled release, slow release or quick releasing formulation.
The pharmaceutical preparation poor for mouthfeel can carry out taste masking at its printout surface correctives thin film.
Described pharmaceutical preparation detects with quality control module fast, adopts at least one near infrared spectrum rapid detection system, Raman spectrum detection system, alternative light source experiment instrument to detect fast.
Described pharmaceutical preparation fast package module, prints being packaged as conventional packaging or being printed as the packaging of different animals, animation shape of gained by 3D.
A kind of 3D prints prescription application method, adopts above-mentioned 3D to print prescription dispenser system, comprises the following steps:
(1) in the printed matter magazine of 3D printer, dress is suitable for highly purified chemical drugs, biological medicament, Chinese medicine extract, the adhesive of 3D printing;
(2) doctor diagnoses patient, according to patient's body constitution and genius morbi, and prescription, the medicine of customized applicable patient and dosage form thereof and dosage, and prescription data is transferred to Preparation Room in Hospital;
(3) after Preparation Room in Hospital receives prescription data, according to the kind of medicine on prescription, dosage form and dosage, 3D print control system carries out quick 3D modeling, and generate print command and be transferred to 3D printer ready-to-print;
(4), after 3D printer receives print command, relevant printing material is sprayed onto by nozzle and is full of N
2on the workbench of gas shield, according to 3DP principle, successively print and realize bonding mutually by adhesive, completing 3D and print, pharmaceutical preparation molding;
(5) the quick sensing chamber of pharmaceutical preparation carries out quick nondestructive detection by least one near infrared spectrum rapid detection system, Raman spectrum detection system or alternative light source experiment instrument to printed pharmaceutical preparation;
(6) for medicine characteristic and patient demand, quick 3D is carried out to the qualified pharmaceutical preparation of detection and print personalized packaging;
(7) packaged pharmaceutical preparation is issued in patient's hands by sending out medicine window by pharmacists.
Beneficial effect of the present invention: the present invention is collection 3D printing hardware and software development, print material (chemical drugs, biological medicament, Chinese medicine extract, adhesive etc.), pharmaceutical preparation sterilizing, to detect and the 3D that is packaged in one prints prescription dispenser system fast, the cost of manufacture of medicine and the warehouse cost of hospital can be reduced; Pharmaceutical preparation can, according to customized pharmaceutical dosage form and the dosage being suitable for patient of patient's body constitution, disease and demand, realize Personalized Drug Administration and precisely treatment, thus make pharmaceutical preparation play greatest treatment efficacy, and it is minimum that poisonous side effect of medicine is dropped to.
Detailed description of the invention
The present invention is that a kind of 3D prints prescription dispenser system, comprising:
Print material and prepare module: according to different printing material medicine being made Powdered, graininess or the liquid state being suitable for that multi-pharmaceutics and 3D print of physicochemical property, and print material and meet medicinal standard.The medicine that printing material is prepared in module can adopt chemical drugs, biological medicament or Chinese medicine.
Pharmaceutical preparation 3D prints manufacturing module: comprise 3D printer and pharmaceutical preparation 3D print control system, and 3D printer prints pharmaceutical preparation according to 3DP principle, and whole print procedure is in being full of N
2carry out (to control pharmaceutical preparation microbial limit and to prevent oxidation of drug, moisture absorption etc.) in the environment of protection gas, by 3D print control system accurately control 3D print the dosage of pharmaceutical preparation and dosage form.3D printer prints pharmaceutical preparation according to 3DP principle, and technique is: after last layer bonding, moulding cylinder declines a distance, to rise a height, release some printing materials, and shifted onto moulding cylinder by powder-laying roller, pave and be compacted for powder cylinder; Shower nozzle 3D print control system control under, by next construction section formed data selectively jet binder build aspect; During powder-laying roller paving powder, unnecessary printing material is collected by powder collection device; So powder feeding again and again, paving powder and jet binder, finally complete the bonding of a three-dimensional powder body.3D printer is equipped with multiinjector, to be adapted in prescription multi-medicament and to realize printing speed.3D print control system should be stablized, simple to operate, accurately can print dosage and the dosage form of pharmaceutical preparation by control 3D, possess the ability printing most solid or semisolid dosage form.Pharmaceutical preparation, in form, can be solid or semi-solid preparation; In dosage form, can be tablet, pill, granule, capsule or suppository; In medicine control, can be controlled release, slow release or quick releasing formulation.The pharmaceutical preparation poor for mouthfeel can carry out taste masking at its printout surface one deck correctives thin film.
Pharmaceutical preparation detects and quality control module fast: the medicament contg, microorganism limitation etc. that 3D are printed to pharmaceutical preparation detect fast, such as, adopt at least one near infrared spectrum rapid detection system, Raman spectrum detection system, alternative light source experiment instrument to detect fast.
Pharmaceutical preparation fast package module: printed by 3D and fast package is carried out to pharmaceutical preparation, and packaging shows drug information, such as, comprise the drug informations such as function cures mainly, usage and dosage, product batch number, date of manufacture.The packaging being printed gained by 3D can be conventional packaging, also can realize packaging for medicine characteristic or patient demand personalized, as: for child patient, the shapes such as the printable one-tenth different animals of pharmaceutical preparation packages, animation, to improve child patient compliance.
A kind of 3D prints prescription application method, comprises the following steps:
(1) in the printed matter magazine of 3D printer, dress is suitable for highly purified chemical drugs, biological medicament, Chinese medicine extract, the adhesive of 3D printing;
(2) doctor diagnoses patient, according to patient's body constitution and genius morbi, and prescription, the medicine of customized applicable patient and dosage form thereof and dosage, and prescription data is transferred to Preparation Room in Hospital;
(3) after Preparation Room in Hospital receives prescription data, according to the kind of medicine on prescription, dosage form and dosage, 3D print control system carries out quick 3D modeling, and generate print command and be transferred to 3D printer ready-to-print;
(4), after 3D printer receives print command, relevant printing material is sprayed onto by nozzle and is full of N
2on the workbench of gas shield, according to 3DP principle, successively print and realize bonding mutually by adhesive, completing 3D and print, pharmaceutical preparation molding;
(5) the quick sensing chamber of pharmaceutical preparation carries out quick nondestructive detection by least one near infrared spectrum rapid detection system, Raman spectrum detection system or alternative light source experiment instrument to printed pharmaceutical preparation;
(6) for medicine characteristic and patient demand, quick 3D is carried out to the qualified pharmaceutical preparation of detection and print personalized packaging;
(7) packaged pharmaceutical preparation is issued in patient's hands by sending out medicine window by pharmacists.
Print prescription dispenser system to 3D set forth in the present invention by way of example to be below described further:
Embodiment 1
Print chemical drugs for 3D, illustrate that 3D prints prescription dispenser system.
(1) in " prepared Chinese ink " box of 3D printer, dress meets the printing material of medicinal standard: high-purity chemical medicine and adhesive;
(2) doctor diagnoses patient, be diagnosed as the heating that common cold causes, according to patient's body constitution and genius morbi, prescription (as table 1), the medicine of customized applicable patient and dosage form thereof and dosage, and by computer, prescription is transferred to Preparation Room in Hospital;
Table 1
(3) after Preparation Room in Hospital receives prescription, according to the kind of medicine on prescription, dosage form and dosage, computer 3D print control system carries out quick 3D modeling, and generate print command and be transferred to 3D printer ready-to-print;
(4), after 3D printer receives print command, " prepared Chinese ink " is sprayed onto by nozzle and is full of N
2on workbench Deng gas shield, according to 3DP principle, medicine successively printed and realizes bonding mutually by adhesive, completing 3D and print, pharmaceutical preparation molding;
(5) the quick sensing chamber of pharmaceutical preparation carries out quick, efficient, undamaged detection by near infrared spectrum rapid detection system, Raman spectrum detection system, alternative light source experiment instrument etc. to printed pharmaceutical preparation, ensures the conformance with standard such as medicament contg, microorganism limitation of preparation;
(6) for medicine characteristic and patient demand, quick 3D being carried out to the qualified pharmaceutical preparation of detection and prints personalized packaging---aluminium-plastic bubble plate packing, packaging comprises the drug informations such as function cures mainly, usage and dosage, product batch number, date of manufacture;
(7) packaged pharmaceutical preparation is issued in patient's hands by sending out medicine window by pharmacists.
Embodiment 2
Print biological medicament for 3D, illustrate that 3D prints prescription dispenser system.
(1) in " prepared Chinese ink " box of 3D printer, dress meets high-purity biological medicament and the adhesive of medicinal standard;
(2) doctor diagnoses patient, be diagnosed as dyspepsia, according to patient's body constitution and genius morbi, prescription (as table 2), the medicine of customized applicable patient and dosage form thereof and dosage, and by computer, prescription is transferred to Preparation Room in Hospital;
Table 2
(3) after Preparation Room in Hospital receives prescription, according to the kind of medicine on prescription, dosage form and dosage, computer 3D print control system carries out quick 3D modeling, and generate print command and be transferred to 3D printer ready-to-print;
(4), after 3D printer receives print command, " prepared Chinese ink " is sprayed onto by nozzle and is full of N
2on workbench Deng gas shield, according to 3DP principle, medicine successively printed and realizes bonding mutually by adhesive, completing 3D and print, pharmaceutical preparation molding;
(5) the quick sensing chamber of pharmaceutical preparation carries out quick, efficient, undamaged detection by near infrared spectrum rapid detection system, Raman spectrum detection system, alternative light source experiment instrument etc. to printed pharmaceutical preparation, ensures the conformance with standard such as medicament contg, microorganism limitation of preparation;
(6) for medicine characteristic and patient demand, quick 3D being carried out to the qualified pharmaceutical preparation of detection and prints personalized packaging---Plastic medicinal bottle is packed, and packaging comprises the drug informations such as function cures mainly, usage and dosage, product batch number, date of manufacture;
(7) packaged pharmaceutical preparation is issued in patient's hands by sending out medicine window by pharmacists.
Embodiment 3
Print Chinese medicine for 3D, illustrate that 3D prints prescription dispenser system.
(1) in " prepared Chinese ink " box of 3D printer, dress meets high-purity Chinese medicine extract and the adhesive of medicinal standard;
(2) doctor diagnoses patient, be diagnosed as anemopyretic cold, according to patient's body constitution and genius morbi, prescription (as table 3), the medicine of customized applicable patient and dosage form thereof and dosage, and by computer, prescription is transferred to Preparation Room in Hospital;
Table 3
(3) after Preparation Room in Hospital receives prescription, according to the kind of medicine on prescription, dosage form and dosage, computer 3D print control system carries out quick 3D modeling, and generate print command and be transferred to 3D printer ready-to-print;
(4), after 3D printer receives print command, " prepared Chinese ink " is sprayed onto by nozzle and is full of N
2on workbench Deng gas shield, according to 3DP principle, medicine successively printed and realizes bonding mutually by adhesive, completing 3D and print, pharmaceutical preparation molding;
(5) the quick sensing chamber of pharmaceutical preparation carries out quick, efficient, undamaged detection by near infrared spectrum rapid detection system, Raman spectrum detection system, alternative light source experiment instrument etc. to printed pharmaceutical preparation, ensures the conformance with standard such as medicament contg, microorganism limitation of preparation;
(6) for medicine characteristic and patient demand, quick 3D being carried out to the qualified pharmaceutical preparation of detection and prints personalized packaging---aluminium-plastic bubble plate packing, packaging comprises the drug informations such as function cures mainly, usage and dosage, product batch number, date of manufacture;
(7) packaged pharmaceutical preparation is issued in patient's hands by sending out medicine window by pharmacists.
Embodiment 4
Print drop pill for 3D, illustrate that 3D prints prescription dispenser system.
(1) in " prepared Chinese ink " box of 3D printer, dress meets high-purity Chinese medicine extract medicine and the adhesive of medicinal standard;
(2) doctor diagnoses patient, be diagnosed as coronary heart disease, according to patient's body constitution and genius morbi, prescription (as table 4), the medicine of customized applicable patient and dosage form (being suitable for the rapid-onset dosage forms such as drop pill) thereof and dosage, and by computer, prescription is transferred to Preparation Room in Hospital;
Table 4
(3) after Preparation Room in Hospital receives prescription, according to the kind of medicine on prescription, dosage form and dosage, computer 3D print control system carries out drop pill (every ball heavy 30mg) 3D modeling fast, and generates print command and be transferred to 3D printer ready-to-print;
(4), after 3D printer receives print command, " prepared Chinese ink " is sprayed onto by nozzle and is full of N
2on workbench Deng gas shield, according to 3DP principle, medicine successively printed and realizes bonding mutually by adhesive, completing 3D and print, pharmaceutical preparation molding;
(5) the quick sensing chamber of pharmaceutical preparation carries out quick, efficient, undamaged detection by near infrared spectrum rapid detection system, Raman spectrum detection system, alternative light source experiment instrument etc. to printed pharmaceutical preparation, ensures the conformance with standard such as medicament contg, microorganism limitation of preparation;
(6) for medicine characteristic and patient demand, quick 3D being carried out to the qualified pharmaceutical preparation of detection and prints personalized packaging---Plastic medicinal bottle is packed, and packaging comprises the drug informations such as function cures mainly, usage and dosage, product batch number, date of manufacture;
(7) packaged pharmaceutical preparation is issued in patient's hands by sending out medicine window by pharmacists.
Embodiment 5
Print taste masking thin film for 3D, illustrate that 3D prints prescription dispenser system.
(1) in " prepared Chinese ink " box of 3D printer, dress meets high-purity Chinese medicine extract and the adhesive of medicinal standard;
(2) doctor diagnoses patient, be diagnosed as three burnt fire-toxicity syndromes, according to patient's body constitution and genius morbi, prescription (as table 5), the medicine of customized applicable patient and dosage form thereof and dosage, and by computer, prescription is transferred to Preparation Room in Hospital;
Table 5
(3) after Preparation Room in Hospital receives prescription, according to the kind of medicine on prescription, dosage form and dosage, computer 3D print control system carries out the quick 3D modeling of Film coated tablets, and generate print command and be transferred to 3D printer ready-to-print;
(4), after 3D printer receives print command, " prepared Chinese ink " is sprayed onto by nozzle and is full of N
2on workbench Deng gas shield, according to 3DP principle, medicine successively printed and realizes bonding mutually by adhesive, completing 3D and print, pharmaceutical preparation molding.Because Rhizoma Coptidis has bitterness, print simultaneously at its outer isochronous printing film-coat, to cover Rhizoma Coptidis bitterness in pharmaceutical preparation;
(5) the quick sensing chamber of pharmaceutical preparation carries out quick, efficient, undamaged detection by near infrared spectrum rapid detection system, Raman spectrum detection system, alternative light source experiment instrument etc. to printed pharmaceutical preparation, ensures the conformance with standard such as medicament contg, microorganism limitation of preparation;
(6) for medicine characteristic and patient demand, quick 3D being carried out to the qualified pharmaceutical preparation of detection and prints personalized packaging---aluminium-plastic bubble plate packing, packaging comprises the drug informations such as function cures mainly, usage and dosage, product batch number, date of manufacture;
(7) packaged pharmaceutical preparation is issued in patient's hands by sending out medicine window by pharmacists.
Embodiment 6
Print personalization with 3D and be packaged as example, illustrate that 3D prints prescription dispenser system.
(1) in " prepared Chinese ink " box of 3D printer, dress meets high-purity Chinese medicine extract and the adhesive of medicinal standard;
(2) doctor diagnoses child patient, is diagnosed as infantile malnutrition, anorexia.According to patient's body constitution and genius morbi, prescription (as table 6), the medicine of customized applicable patient and dosage form thereof and dosage, and by computer, prescription is transferred to Preparation Room in Hospital;
Table 6
(3) after Preparation Room in Hospital receives prescription, according to the kind of medicine on prescription, dosage form and dosage, computer 3D print control system carries out quick 3D modeling, and generate print command and be transferred to 3D printer ready-to-print;
(4), after 3D printer receives print command, " prepared Chinese ink " is sprayed onto by nozzle and is full of N
2on workbench Deng gas shield, according to 3DP principle, medicine successively printed and realizes bonding mutually by adhesive, completing 3D and print, pharmaceutical preparation molding;
(5) the quick sensing chamber of pharmaceutical preparation carries out quick, efficient, undamaged detection by near infrared spectrum rapid detection system, Raman spectrum detection system, alternative light source experiment instrument etc. to printed pharmaceutical preparation, ensures the conformance with standard such as medicament contg, microorganism limitation of preparation;
(6) for medicine characteristic and patient demand, quick 3D being carried out to the qualified pharmaceutical preparation of detection and prints personalized packaging---packet printing becomes Little Bear shape, to improve the compliance of child patient.Packaging comprises the drug informations such as function cures mainly, usage and dosage, product batch number, date of manufacture;
(7) packaged pharmaceutical preparation is issued in patient's hands by sending out medicine window by pharmacists.
Claims (9)
1. 3D prints a prescription dispenser system, it is characterized in that comprising:
Print material and prepare module: according to different printing material medicine being made Powdered, graininess or the liquid state being suitable for that multi-pharmaceutics and 3D print of physicochemical property, and print material and meet medicinal standard;
Pharmaceutical preparation 3D prints manufacturing module: comprise 3D printer and pharmaceutical preparation 3D print control system, and 3D printer prints pharmaceutical preparation according to 3DP principle, and whole print procedure is in being full of N
2carry out in the environment of protection gas, by 3D print control system accurately control 3D print the dosage of pharmaceutical preparation and dosage form;
Pharmaceutical preparation detects and quality control module fast: the medicament contg, microorganism limitation etc. that 3D are printed to pharmaceutical preparation detect fast;
Pharmaceutical preparation fast package module: printed by 3D and fast package is carried out to pharmaceutical preparation, and packaging shows drug information.
2. 3D according to claim 1 prints prescription dispenser system, it is characterized in that: the described printing material medicine prepared in module is chemical drugs, biological medicament or Chinese medicine.
3. 3D according to claim 1 prints prescription dispenser system, it is characterized in that: described 3D printer prints pharmaceutical preparation according to 3DP principle, technique is: after last layer bonding, moulding cylinder declines a distance, one is risen highly for powder cylinder, release some printing materials, and shifted onto moulding cylinder by powder-laying roller, pave and be compacted; Shower nozzle 3D print control system control under, by next construction section formed data selectively jet binder build aspect; During powder-laying roller paving powder, unnecessary printing material is collected by powder collection device; So powder feeding again and again, paving powder and jet binder, finally complete the bonding of a three-dimensional powder body.
4. 3D according to claim 1 prints prescription dispenser system, it is characterized in that: described 3D printer is equipped with multiinjector.
5. 3D according to claim 1 prints prescription dispenser system, it is characterized in that: described pharmaceutical preparation, in form, can be solid or semi-solid preparation; In dosage form, can be tablet, pill, granule, capsule or suppository; In medicine control, can be controlled release, slow release or quick releasing formulation.
6. 3D according to claim 1 prints prescription dispenser system, it is characterized in that: the pharmaceutical preparation poor for mouthfeel can carry out taste masking at its printout surface correctives thin film.
7. 3D according to claim 1 prints prescription dispenser system, it is characterized in that: described pharmaceutical preparation detects with quality control module fast, adopt at least one near infrared spectrum rapid detection system, Raman spectrum detection system, alternative light source experiment instrument to detect fast.
8. 3D according to claim 1 prints prescription dispenser system, it is characterized in that: described pharmaceutical preparation fast package module, prints being packaged as conventional packaging or being printed as the packaging of different animals, animation shape of gained by 3D.
9. 3D prints a prescription application method, adopts 3D described in claim 1-8 to print prescription dispenser system, comprises the following steps:
(1) in the printed matter magazine of 3D printer, dress is suitable for highly purified chemical drugs, biological medicament, Chinese medicine extract, the adhesive of 3D printing;
(2) doctor diagnoses patient, according to patient's body constitution and genius morbi, and prescription, the medicine of customized applicable patient and dosage form thereof and dosage, and prescription data is transferred to Preparation Room in Hospital;
(3) after Preparation Room in Hospital receives prescription data, according to the kind of medicine on prescription, dosage form and dosage, 3D print control system carries out quick 3D modeling, and generate print command and be transferred to 3D printer ready-to-print;
(4), after 3D printer receives print command, relevant printing material is sprayed onto by nozzle and is full of N
2on the workbench of gas shield, according to 3DP principle, successively print and realize bonding mutually by adhesive, completing 3D and print, pharmaceutical preparation molding;
(5) the quick sensing chamber of pharmaceutical preparation carries out quick nondestructive detection by least one near infrared spectrum rapid detection system, Raman spectrum detection system or alternative light source experiment instrument to printed pharmaceutical preparation;
(6) for medicine characteristic and patient demand, quick 3D is carried out to the qualified pharmaceutical preparation of detection and print personalized packaging;
(7) packaged pharmaceutical preparation is issued in patient's hands by sending out medicine window by pharmacists.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610053263.8A CN105534713A (en) | 2016-01-25 | 2016-01-25 | Prescription-applied drug 3D printing system and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610053263.8A CN105534713A (en) | 2016-01-25 | 2016-01-25 | Prescription-applied drug 3D printing system and method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105534713A true CN105534713A (en) | 2016-05-04 |
Family
ID=55814649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610053263.8A Pending CN105534713A (en) | 2016-01-25 | 2016-01-25 | Prescription-applied drug 3D printing system and method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105534713A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074412A (en) * | 2016-07-05 | 2016-11-09 | 南方医科大学 | A kind of 3D prints Folium Crataegi total flavones dispersible tablet and preparation method thereof |
| CN106821755A (en) * | 2017-02-17 | 2017-06-13 | 广东药科大学 | A kind of preparation method of any dose tablet based on 3D printing |
| US11724486B2 (en) | 2019-07-09 | 2023-08-15 | Kyndryl, Inc. | Printing customized medication based on current user data and medical records of the user |
| CN117568440A (en) * | 2024-01-17 | 2024-02-20 | 中国科学院化学研究所 | Drug screening method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393543A (en) * | 2013-08-02 | 2013-11-20 | 魏雪纹 | Method using 3D printing technology to prepare dropping pills |
| CN104337754A (en) * | 2013-08-02 | 2015-02-11 | 厦门塔斯曼生物工程有限公司 | Method for designing and manufacturing biochemistry medicament product based on 3D printing technology |
| CN204352789U (en) * | 2015-01-01 | 2015-05-27 | 冯福林 | A kind of medicine ordinance 3D printer |
| CN104886738A (en) * | 2015-06-05 | 2015-09-09 | 郑蕾娜 | A manufacturing method of traditional Chinese medicines or medicined diets based on 3D printing |
-
2016
- 2016-01-25 CN CN201610053263.8A patent/CN105534713A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393543A (en) * | 2013-08-02 | 2013-11-20 | 魏雪纹 | Method using 3D printing technology to prepare dropping pills |
| CN104337754A (en) * | 2013-08-02 | 2015-02-11 | 厦门塔斯曼生物工程有限公司 | Method for designing and manufacturing biochemistry medicament product based on 3D printing technology |
| CN204352789U (en) * | 2015-01-01 | 2015-05-27 | 冯福林 | A kind of medicine ordinance 3D printer |
| CN104886738A (en) * | 2015-06-05 | 2015-09-09 | 郑蕾娜 | A manufacturing method of traditional Chinese medicines or medicined diets based on 3D printing |
Non-Patent Citations (3)
| Title |
|---|
| IULIA URSAN 等: "Three-dimensional drug printing: A structured review", 《JOUR NAL OF THE AMERICAN PHAR MACISTS ASSOCIATION》 * |
| JONATHAN GOOLE 等: "3D printing in pharmaceutics: A new tool for designing customized drug delivery systems", 《INTERNATIONAL JOURNAL OF PHARMACEUTICS》 * |
| 刘珍 等: "首款3D打印抗癫痫药物———Spritam", 《药学研究》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074412A (en) * | 2016-07-05 | 2016-11-09 | 南方医科大学 | A kind of 3D prints Folium Crataegi total flavones dispersible tablet and preparation method thereof |
| CN106821755A (en) * | 2017-02-17 | 2017-06-13 | 广东药科大学 | A kind of preparation method of any dose tablet based on 3D printing |
| US11724486B2 (en) | 2019-07-09 | 2023-08-15 | Kyndryl, Inc. | Printing customized medication based on current user data and medical records of the user |
| CN117568440A (en) * | 2024-01-17 | 2024-02-20 | 中国科学院化学研究所 | Drug screening method |
| CN117568440B (en) * | 2024-01-17 | 2024-05-07 | 中国科学院化学研究所 | Drug screening method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20230330035A1 (en) | Systems of on-demand customized medicament doses by 3d printing | |
| EP1306071B1 (en) | A method and dosage form for dispensing a bioactive substance | |
| CN105534713A (en) | Prescription-applied drug 3D printing system and method | |
| KR101936958B1 (en) | Discharging methods and packagings for oral medications | |
| West et al. | 3D printing: a case of ZipDose® technology–world's first 3D printing platform to obtain FDA approval for a pharmaceutical product | |
| US6981592B2 (en) | Product packaging material for individual temporary storage of pharmaceutical products | |
| Melnyk et al. | Integration of 3D printing technology in pharmaceutical compounding: Progress, prospects, and challenges | |
| CN107072877A (en) | Drug packages and dosage system | |
| US20100108559A1 (en) | Packaged product combination | |
| KR20130009661A (en) | Administration methods and packagings for dosage units | |
| KR20150078774A (en) | Methods and device for making drugs with 3D printing technique | |
| US20230053278A1 (en) | Pharmacy assembly machine and packaging for customised polypills, and customised antipsychotic combinations for improved compliance | |
| Genina et al. | 3D printing in oral drug delivery | |
| JPH06190020A (en) | Packaged medical supply | |
| US20200115074A1 (en) | Methods and Apparatus for Automatically Filling Dispensing Containers | |
| KR101253588B1 (en) | Method for manufacturing the prescription printing paper with a medicine envelope | |
| Preis | Potential of 3D printing in pharmaceutical drug delivery and manufacturing | |
| EP3839921A1 (en) | Multi-layered buccal dosage form and method for the production thereof | |
| CN2766833Y (en) | Medicament box for hospital ward | |
| JP4987192B2 (en) | Packaging system according to the time of taking medicine | |
| EP3636240A1 (en) | Methods and apparatus for automatically filling dispensing containers | |
| Sabitha et al. | STUDY OF INCONVENIENCES IN SOLID PEDIATRIC MEDICATION AND FORMULATION OF SUSPENSION OF AMLODIPINE | |
| Preis | Towards printing of medicine in 2D and 3D | |
| Ohi | Design and optimization of 3D printed Orodispersible Film | |
| KR200360542Y1 (en) | Medicine receipt case having Date discernment part for one times |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160504 |
|
| RJ01 | Rejection of invention patent application after publication |