CN105520915A - Fenoprofen sustained-release tablets and preparation method thereof - Google Patents
Fenoprofen sustained-release tablets and preparation method thereof Download PDFInfo
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- CN105520915A CN105520915A CN201410516666.2A CN201410516666A CN105520915A CN 105520915 A CN105520915 A CN 105520915A CN 201410516666 A CN201410516666 A CN 201410516666A CN 105520915 A CN105520915 A CN 105520915A
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- fenoprofen
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- calcium
- tablet
- sustained release
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- 238000002360 preparation method Methods 0.000 title claims abstract description 46
- 239000007939 sustained release tablet Substances 0.000 title claims abstract description 32
- RDJGLLICXDHJDY-NSHDSACASA-N (2s)-2-(3-phenoxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](C)C1=CC=CC(OC=2C=CC=CC=2)=C1 RDJGLLICXDHJDY-NSHDSACASA-N 0.000 title claims abstract description 31
- 229960001419 fenoprofen Drugs 0.000 title claims abstract description 31
- 229960005341 fenoprofen calcium Drugs 0.000 claims abstract description 26
- VHUXSAWXWSTUOD-UHFFFAOYSA-L fenoprofen calcium (anhydrous) Chemical compound [Ca+2].[O-]C(=O)C(C)C1=CC=CC(OC=2C=CC=CC=2)=C1.[O-]C(=O)C(C)C1=CC=CC(OC=2C=CC=CC=2)=C1 VHUXSAWXWSTUOD-UHFFFAOYSA-L 0.000 claims abstract description 26
- 239000000463 material Substances 0.000 claims abstract description 13
- 239000011230 binding agent Substances 0.000 claims abstract description 9
- 239000000314 lubricant Substances 0.000 claims abstract description 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 6
- 239000003826 tablet Substances 0.000 claims description 26
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 24
- 239000011575 calcium Substances 0.000 claims description 24
- 229910052791 calcium Inorganic materials 0.000 claims description 24
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 14
- 239000008187 granular material Substances 0.000 claims description 13
- -1 hydroxypropyl Chemical group 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 8
- 230000001476 alcoholic effect Effects 0.000 claims description 8
- 238000013270 controlled release Methods 0.000 claims description 8
- 239000007779 soft material Substances 0.000 claims description 8
- 235000019359 magnesium stearate Nutrition 0.000 claims description 7
- 239000004925 Acrylic resin Substances 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 6
- 239000011347 resin Substances 0.000 claims description 6
- 229920005989 resin Polymers 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 6
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 5
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 5
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 5
- 239000000741 silica gel Substances 0.000 claims description 5
- 229910002027 silica gel Inorganic materials 0.000 claims description 5
- 239000002002 slurry Substances 0.000 claims description 4
- 239000001856 Ethyl cellulose Substances 0.000 claims description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 3
- 229920001249 ethyl cellulose Polymers 0.000 claims description 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000004744 fabric Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 3
- 238000004090 dissolution Methods 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 239000002253 acid Substances 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 239000003607 modifier Substances 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 4
- 206010013786 Dry skin Diseases 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 206010002556 Ankylosing Spondylitis Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 206010018634 Gouty Arthritis Diseases 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 208000001294 Nociceptive Pain Diseases 0.000 description 1
- 102000011759 adducin Human genes 0.000 description 1
- 108010076723 adducin Proteins 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 108010017796 epoxidase Proteins 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 150000008134 glucuronides Chemical group 0.000 description 1
- YPGCWEMNNLXISK-UHFFFAOYSA-N hydratropic acid Chemical class OC(=O)C(C)C1=CC=CC=C1 YPGCWEMNNLXISK-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 230000008058 pain sensation Effects 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The invention relates to fenoprofen sustained-release tablets and a preparation method thereof. The fenoprofen sustained-release tablets prepared by the method comprise fenoprofen calcium serving as the main medicine and pharmaceutic adjuvant, wherein the pharmaceutic adjuvant includes acid environment modifier, sustained-release materials, binder and lubricant. The fenoprofen sustained-release tablets prepared by the method has the advantages that the side effects of the fenoprofen sustained-release tablets are reduced, the safety of the fenoprofen sustained-release tablets is increased, the fenoprofen sustained-release tablets are good in stability, fast in dissolution and good in releasing rate, administration frequency is reduced, and the compliance of a patient is increased. The preparation method is simple, suitable for industrial production and promising in market prospect.
Description
Technical field
The present invention relates to biomedical product field, particularly a kind of fenoprofen sustained release tablet of calcium and preparation method thereof.
Background technology
Fenoprofen calcium is a kind of anti-inflammatory analgesic.This product is white crystalline powder; Odorless, tasteless.Dissolve in ethanol, slightly soluble in methanol, soluble,very slightly in water, almost insoluble in chloroform.Be applicable to various arthritis, comprise rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gouty arthritis and other soft tissue pains.Also for other pain as dysmenorrhea, toothache, damage and traumatic pain etc.This product is also phenylpropionic acid derivative, is NSAID (non-steroidal anti-inflammatory drug); Reduced the synthesis of prostaglandin by the suppression to epoxidase, therefore alleviate the sensitivity of tissue hyperemia, swelling, the reduction peripheral nerve pain sensation.It plays refrigeration function by hypothalamus center of body temperature regulation.Absorbed following oral administration is fast, and absorb when roughly the same taking with food, milk and slow down, 1 ~ 2 hour blood drug level peaking after single administration 600mg, concentration is 50mg/ml, and protein binding rate is 99%.T1/2 is 3 hours, discharges in 90% in 24 hours from urine.Mainly discharge with glucuronide form.About 2% discharges from feces.This product is because the half-life is short, medication frequent and stimulate gastrointestinal therefore be suitable for making slow releasing preparation to solve above deficiency.
Summary of the invention
The present invention aims to provide a kind of fenoprofen sustained release tablet of calcium and preparation method thereof, thus the solution fenoprofen calcium conventional formulation half-life is short, medication problem frequently.
For achieving the above object, a kind of fenoprofen sustained release tablet of calcium of the present invention and preparation method thereof, technical scheme is:
A kind of fenoprofen sustained release tablet of calcium of the present invention and preparation method thereof, is characterized in that this slow releasing tablet is made up of principal agent fenoprofen calcium and pharmaceutic adjuvant, and pharmaceutic adjuvant comprises sour environment regulator, slow controlled-release material, binding agent, lubricant.
A kind of fenoprofen sustained release tablet of calcium of the present invention and preparation method thereof, is characterized in that each weight percentages of components of this slow releasing tablet is counted:
Fenoprofen calcium 10-99% sour environment regulator 1%-10%
Slow controlled-release material 10-65% lubricant 1%-5% binding agent 1-10%.
A kind of fenoprofen sustained release tablet of calcium of the present invention and preparation method thereof, is characterized in that the preparation method of this slow releasing tablet is:
1) above-mentioned supplementary material is crossed 100 sieves for subsequent use;
2) take fenoprofen calcium by prescription, mix with the sour environment regulator controlled-release material that eases up, cross 50-100 mesh sieve, mixing, adds binding agent soft material;
3) by step 2) gained soft material crosses 10-30 screen cloth and granulates, with 10-30 mesh sieve granulate after dry;
4) add mix lubricant even, rush in row tabletting with 11mm, adjustment tableting pressure and sheet weight, be pressed into tablet.
A kind of fenoprofen sustained release tablet of calcium of the present invention and preparation method thereof, is characterized in that the sour environment regulator of this slow releasing tablet is acrylic acid
number resin salt hydrochlorate.
A kind of fenoprofen sustained release tablet of calcium of the present invention and preparation method thereof, is characterized in that the slow controlled-release material of this slow releasing tablet is one or more in hydroxypropyl cellulose, hydroxypropyl emthylcellulose, polyacrylic resin II, ethyl cellulose, sodium carboxymethyl cellulose.
A kind of fenoprofen sustained release tablet of calcium of the present invention and preparation method thereof, is characterized in that the lubricant of this slow releasing tablet is one or both in magnesium stearate, micropowder silica gel.
A kind of fenoprofen sustained release tablet of calcium of the present invention and preparation method thereof, is characterized in that the binding agent of this slow releasing tablet is 60-95% alcoholic solution or 5-8% starch slurry.
A kind of fenoprofen sustained release tablet of calcium of the present invention and preparation method thereof, is characterized in that this preparation method step 2) cross 65 mesh sieve 3 times.
A kind of fenoprofen sustained release tablet of calcium of the present invention and preparation method thereof, is characterized in that this preparation method step 3) baking temperature is 55-70 DEG C.
A kind of fenoprofen sustained release tablet of calcium of the present invention and preparation method thereof, is characterized in that this preparation method step 4) gained tablet hardness is 5kg/cm
2, sheet is heavily 0.6g.
Beneficial effect of the present invention has:
1. reduce the side effect of preparation, improve the safety of preparation;
2. medicine stability is good, and release conforms with the regulations, and reduces administration frequency, increases the compliance of patient;
3. simple for process, be applicable to industrialized great production.
accompanying drawing illustrates:
Fig. 1 is: fenoprofen calcium dissolution of sustained-release tablets curve chart.
Detailed description of the invention
Following embodiment only for further illustrating technical solution of the present invention, does not limit the present invention in any form.
embodiment 1
The following film-making of prescription 1000 of fenoprofen calcium:
| Name of material | Consumption (g) | Ratio (%) |
| Fenoprofen calcium | 300 | 50 |
| Acrylic acid Number resin salt hydrochlorate | 30 | 5 |
| Hydroxypropyl cellulose | 60 | 10 |
| Hydroxypropyl emthylcellulose | 120 | 20 |
| 60% alcoholic solution | In right amount | - |
| Polyacrylic resin II | 36 | 6 |
| Magnesium stearate | 12 | 2 |
Preparation method: above-mentioned supplementary material is crossed 100 mesh sieves for subsequent use, take fenoprofen calcium by prescription, starch mixes, cross 65 mesh sieve 3 times, mixing, then add the hydroxypropyl emthylcellulose mixing of recipe quantity, add 60% alcoholic solution soft material, cross 20 eye mesh screens and granulate, after 55 DEG C of dryings, use 24 mesh sieve granulate.Add magnesium stearate mix homogeneously, rush in row tabletting with 11mm, adjustment tableting pressure and sheet weight, be pressed into slice, thin piece hardness and be about 5kg/cm
2, sheet is heavily about the tablet of 0.6g.Fenoprofen calcium tablet is gone out by above formula preparation.
embodiment 2
The following film-making of prescription 1000 of fenoprofen calcium:
| Name of material | Consumption (g) | Ratio (%) |
| Fenoprofen calcium | 180 | 30 |
| Acrylic acid Number resin salt hydrochlorate | 30 | 5 |
| Hydroxypropyl cellulose | 120 | 20 |
| Hydroxypropyl emthylcellulose | 150 | 25 |
| 75% alcoholic solution | In right amount | - |
| Polyacrylic resin II | 48 | 8 |
| Micropowder silica gel | 12 | 2 |
Preparation method: above-mentioned supplementary material is crossed 100 mesh sieves for subsequent use, take fenoprofen calcium by prescription, starch mixes, cross 65 mesh sieve 3 times, mixing, then add the hydroxypropyl emthylcellulose mixing of recipe quantity, add 75% alcoholic solution soft material, cross 20 eye mesh screens and granulate, after 60 DEG C of dryings, use 24 mesh sieve granulate.Add micropowder silica gel mix homogeneously, rush in row tabletting with 11mm, adjustment tableting pressure and sheet weight, be pressed into slice, thin piece hardness and be about 5kg/cm
2, sheet is heavily about the tablet of 0.6g.Fenoprofen calcium tablet is gone out by above formula preparation.
embodiment 3
The following film-making of prescription 1000 of fenoprofen calcium:
| Name of material | Consumption (g) | Ratio (%) |
| Fenoprofen calcium | 300 | 50 |
| Acrylic acid Number resin salt hydrochlorate | 30 | 5 |
| Ethyl cellulose | 60 | 10 |
| Hydroxypropyl emthylcellulose | 120 | 20 |
| Sodium carboxymethyl cellulose | 60 | 10 |
| 95% alcoholic solution | In right amount | - |
| Polyacrylic resin II | 18 | 3 |
| Magnesium stearate | 12 | 2 |
Preparation method: above-mentioned supplementary material is crossed 100 mesh sieves for subsequent use, fenoprofen calcium is taken by prescription, sodium carboxymethyl cellulose mixes, cross 65 mesh sieve 3 times, mixing, then the hydroxypropyl emthylcellulose mixing adding recipe quantity, add 95% alcoholic solution soft material, cross 20 eye mesh screens to granulate, after 65 DEG C of dryings, use 24 mesh sieve granulate.Add magnesium stearate mix homogeneously, rush in row tabletting with 11mm, adjustment tableting pressure and sheet weight, be pressed into slice, thin piece hardness and be about 5kg/cm
2, sheet is heavily about the tablet of 0.6g.Fenoprofen calcium tablet is gone out by above formula preparation.
embodiment 4
The following film-making of prescription 1000 of fenoprofen calcium:
| Name of material | Consumption (g) | Ratio (%) |
| Fenoprofen calcium | 180 | 30 |
| Acrylic acid Number resin salt hydrochlorate | 30 | 5 |
| Hydroxypropyl cellulose | 120 | 20 |
| Hydroxypropyl emthylcellulose | 150 | 25 |
| 8% starch slurry | In right amount | - |
| Sodium carboxymethyl cellulose | 60 | 10 |
| Polyacrylic resin II | 48 | 8 |
| Micropowder silica gel | 12 | 2 |
Preparation method: above-mentioned supplementary material is crossed 100 mesh sieves for subsequent use, fenoprofen calcium is taken by prescription, sodium carboxymethyl cellulose mixes, cross 65 mesh sieve 3 times, mixing, then the hydroxypropyl emthylcellulose mixing adding recipe quantity, add 8% starch slurry soft material, cross 20 eye mesh screens to granulate, after 70 DEG C of dryings, use 24 mesh sieve granulate.Add magnesium stearate mix homogeneously, rush in row tabletting with 11mm, adjustment tableting pressure and sheet weight, be pressed into slice, thin piece hardness and be about 5kg/cm
2, sheet is heavily about the tablet of 0.6g.Fenoprofen calcium tablet is gone out by above formula preparation.
Embodiment 1-4 release changes experimental data in time:
| Time | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 |
| 0 | 0 | 0 | 0 | 0 |
| 2 | 10.43 | 5.21 | 7.36 | 8.97 |
| 4 | 25.52 | 19.37 | 15.98 | 17.76 |
| 6 | 45.75 | 38.34 | 42.89 | 35.88 |
| 8 | 70.47 | 60.24 | 55.56 | 65.65 |
| 10 | 88.42 | 78.87 | 72.87 | 75.66 |
| 12 | 98.68 | 89.69 | 85.07 | 93.96 |
Claims (10)
1. fenoprofen sustained release tablet of calcium and preparation method thereof, is characterized in that this slow releasing tablet is made up of principal agent fenoprofen calcium and pharmaceutic adjuvant, and pharmaceutic adjuvant comprises sour environment regulator, slow controlled-release material, binding agent, lubricant.
2. a kind of fenoprofen sustained release tablet of calcium and preparation method thereof according to claim 1, is characterized in that each weight percentages of components of this slow releasing tablet is counted:
Fenoprofen calcium 10-99% sour environment regulator 1%-10%
Slow controlled-release material 10-65% lubricant 1%-5% binding agent 1-10%.
3. a kind of fenoprofen sustained release tablet of calcium and preparation method thereof according to claim 1, is characterized in that the preparation method of this slow releasing tablet is:
1) above-mentioned supplementary material is crossed 100 sieves for subsequent use;
2) take fenoprofen calcium by prescription, mix with the sour environment regulator controlled-release material that eases up, cross 50-100 mesh sieve, mixing, adds binding agent soft material;
3) by step 2) gained soft material crosses 10-30 screen cloth and granulates, with 10-30 mesh sieve granulate after dry, dry, granulate;
4) add mix lubricant even, carry out tabletting with 11mm punch die, adjustment tableting pressure and sheet weight, be pressed into tablet.
4. a kind of fenoprofen sustained release tablet of calcium and preparation method thereof according to claim 1, is characterized in that the sour environment regulator of this slow releasing tablet is acrylic acid
number resin salt hydrochlorate.
5. a kind of fenoprofen sustained release tablet of calcium and preparation method thereof according to claim 1, is characterized in that the slow controlled-release material of this slow releasing tablet is one or more in hydroxypropyl cellulose, hydroxypropyl emthylcellulose, polyacrylic resin II, ethyl cellulose, sodium carboxymethyl cellulose.
6. a kind of fenoprofen sustained release tablet of calcium and preparation method thereof according to claim 1, is characterized in that the lubricant of this slow releasing tablet is one or both in magnesium stearate, micropowder silica gel.
7. a kind of fenoprofen sustained release tablet of calcium and preparation method thereof according to claim 1, is characterized in that the binding agent of this slow releasing tablet is 60-95% alcoholic solution or 5-8% starch slurry.
8. a kind of fenoprofen sustained release tablet of calcium and preparation method thereof according to claim 3, is characterized in that this preparation method step 2) cross 65 mesh sieve 3 times.
9. a kind of fenoprofen sustained release tablet of calcium and preparation method thereof according to claim 3, is characterized in that this preparation method step 3) baking temperature is 55-70 DEG C.
10. a kind of fenoprofen sustained release tablet of calcium and preparation method thereof according to claim 3, is characterized in that this preparation method step 4) gained tablet hardness is 5kg/cm
2, sheet is heavily 0.6g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410516666.2A CN105520915A (en) | 2014-09-30 | 2014-09-30 | Fenoprofen sustained-release tablets and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410516666.2A CN105520915A (en) | 2014-09-30 | 2014-09-30 | Fenoprofen sustained-release tablets and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105520915A true CN105520915A (en) | 2016-04-27 |
Family
ID=55763670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410516666.2A Pending CN105520915A (en) | 2014-09-30 | 2014-09-30 | Fenoprofen sustained-release tablets and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105520915A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1352938A (en) * | 2000-11-14 | 2002-06-12 | 北京万全阳光医药科技有限公司 | Slowly releasing bupropion hydrochloride tablet |
-
2014
- 2014-09-30 CN CN201410516666.2A patent/CN105520915A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1352938A (en) * | 2000-11-14 | 2002-06-12 | 北京万全阳光医药科技有限公司 | Slowly releasing bupropion hydrochloride tablet |
Non-Patent Citations (3)
| Title |
|---|
| 李娟等: "非诺洛芬钙缓释片的研制及释药性质研究", 《中国药科大学学报》 * |
| 赵春顺等: "非诺洛芬钙亲水凝胶缓释骨架片释药机理的研究", 《药学学报》 * |
| 赵春顺等: "非诺洛芬钙缓释片的制备及其人体药动学初步研究", 《中国药学杂志》 * |
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Application publication date: 20160427 |
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