CN105520841A - Thiamine disulfide granules and preparation method thereof - Google Patents
Thiamine disulfide granules and preparation method thereof Download PDFInfo
- Publication number
- CN105520841A CN105520841A CN201410567255.6A CN201410567255A CN105520841A CN 105520841 A CN105520841 A CN 105520841A CN 201410567255 A CN201410567255 A CN 201410567255A CN 105520841 A CN105520841 A CN 105520841A
- Authority
- CN
- China
- Prior art keywords
- tatd
- granule
- preparation
- make
- binding agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of feed industry, and particularly relates to thiamine disulfide granules. Thiamine disulfide is used as an active ingredient, and other pharmaceutical excipients are used as a wetting agent, a binding agent and the like. Measured bulk density of the granules is 0.4-0.65 g/ml while fluidity (calculated through aperture of a disc) of the same is less than or equal to 10 mm.
Description
Technical field
The present invention relates to improving one's methods of a kind of stable TATD granule prepared containing a small amount of adjuvant.In addition, the TATD granule that the present invention relates to, is characterized in that having particularly preferred mobility.
Background technology
TATD is a kind of derivant of vitamin B1, also has preferably Study On The Radioprotective.So in cosmetics and feed industry extensive use.Because the former powder of TATD is crystalline powder, bulk density is little, causes mobility poor, and during application, dust-producing amount is large, and premix difficulty, TATD granule overcomes above-mentioned defect as additive, is convenient to suitability for industrialized production.
Along with the raising of drug preparation technique, and the continuous appearance of novel adjuvant, the crystalline powder medicine of high-load improves mobility and should say it is not what difficult matter.But will solve the mobility (apertometer with by disk) that content is not less than 98% TATD and reach below 10mm, such method needs really always.
This TATD, except having except good mobility to cosmetics and feed technology application, also has more than high-bulk-density 0.40g/ml usually.
Summary of the invention
The object of this invention is to provide a kind of TATD granule and preparation method thereof, have simple process, quality controllable and be suitable for the advantage of suitability for industrialized production, and this TATD mobility of particle is good, bulk density is high.
In order to realize above-mentioned goal of the invention, the technical solution used in the present invention is:
TATD amount of particles of the present invention is weight 100 parts, adjuvant 0.05-0.1 part.
TATD granule of the present invention, adjuvant used is selected from one or more mixture in hydroxypropyl emthylcellulose or polyvinylpyrrolidone or methylcellulose or mannitol, glucose, nicotiamide.
TATD granule of the present invention, solvent used is selected from one or more mixture in water or ethanol or vegetable oil.
The preparation method of TATD granule of the present invention is as follows:
Adjuvant is made into serosity, and TATD weighs up and is placed in efficient wet granulator, adds a little serosity, stirs and makes into granule; Dry through fluid bed for 50-70 DEG C; Cross vibration screening grain.
The invention has the beneficial effects as follows: select above-mentioned solvent and adjuvant, can effectively and TATD stick into granule into good fluidity, improve the mobility of TATD, improve its bulk density.The preparation method of described TATD granule has simple process, quality controllable and be suitable for the advantage of suitability for industrialized production.
Detailed description of the invention
In order to understand technical scheme of the present invention better, be described in further detail below by way of specific embodiment.
Embodiment 1:
Get polyvinylpyrrolidone 2g, add water and make serosity, TATD is inserted in comminutor, adds the serosity prepared, stirs, make into granule, 65 DEG C of fluid bed dryings, then crosses 40 order shaking screens, obtains TATD granule.
Embodiment 2:
Get hydroxypropyl emthylcellulose 2g, add water and make serosity, TATD is inserted in comminutor, adds the serosity prepared, stirs, make into granule, 65 DEG C of fluid bed dryings, then crosses 40 order shaking screens, obtains TATD granule.
Embodiment 3:
Get mannitol 4g to add water and make serosity, TATD is inserted in comminutor, adds the serosity prepared, stirs, make into granule, 65 DEG C of fluid bed dryings, then crosses 40 order shaking screens, obtains TATD granule.
Embodiment 4:
Get glucose 4g to add water and make serosity, TATD is inserted in comminutor, adds the serosity prepared, stirs, make into granule, 65 DEG C of fluid bed dryings, then crosses 40 order shaking screens, obtains TATD granule.
Embodiment 5:
Get nicotiamide 4g to add water and make serosity, TATD is inserted in comminutor, adds the serosity prepared, stirs, make into granule, 65 DEG C of fluid bed dryings, then crosses 40 order shaking screens, obtains TATD granule.
Embodiment 6:
Get polyvinylpyrrolidone 2g, mannitol 2g adds water and makes serosity, TATD is inserted in comminutor, adds the serosity prepared, stirs, make into granule, 65 DEG C of fluid bed dryings, then crosses 40 order shaking screens, obtains TATD granule.
Embodiment 7:
Get polyvinylpyrrolidone 2g, nicotiamide 2g adds water and makes serosity, TATD is inserted in comminutor, adds the serosity prepared, stirs, make into granule, 65 DEG C of fluid bed dryings, then crosses 40 order shaking screens, obtains TATD granule.
Claims (5)
1. the preparation method for direct premix TATD granule; it is characterized in that: first the TATD of 100 parts is dropped in efficient wet granulator; then 50 parts of mixed adhesive solution are added; binder solution concentration is 1.0 % by weight; be uniformly mixed 10-30 minute; namely become TATD wet granular, the TATD wet granular made is transferred in ebullated dryer and carries out drying and make granule become the granule of TATD content >=98%, mobility (apertometer with by disk)≤10mm.
2. TATD granule as claimed in claim 1, is characterized in that: described binding agent is selected from one or more mixture in hydroxypropyl emthylcellulose or polyvinylpyrrolidone or ethyl cellulose or methylcellulose or sodium carboxymethyl cellulose or microcrystalline Cellulose, mannitol, glucose, nicotiamide.
3. TATD granule as claimed in claim 1 or 2, is characterized in that: described solvent is selected from one or more mixture in water or ethanol or vegetable oil.
4. the TATD granule according to any one of claim 1-3, is characterized in that: can be used for feed additive for fowls.
5. prepare a preparation method for the TATD granule according to any one of claim 1-4, it is characterized in that, comprise the following steps:
A, TATD to be weighed up, be placed in efficient wet granulator, add a certain amount of binding agent, stir and make into granule;
Dry through fluid bed for B, 50-70 DEG C;
C, excessively vibration screening grain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410567255.6A CN105520841A (en) | 2014-10-23 | 2014-10-23 | Thiamine disulfide granules and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410567255.6A CN105520841A (en) | 2014-10-23 | 2014-10-23 | Thiamine disulfide granules and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105520841A true CN105520841A (en) | 2016-04-27 |
Family
ID=55763596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410567255.6A Pending CN105520841A (en) | 2014-10-23 | 2014-10-23 | Thiamine disulfide granules and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105520841A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85107365A (en) * | 1984-10-09 | 1986-10-01 | 武田药品工业株式会社 | The granule of thiamine salt and production thereof |
| JPH0952832A (en) * | 1995-08-10 | 1997-02-25 | Takeda Chem Ind Ltd | Medicinal composition |
| CN101654440A (en) * | 2009-07-28 | 2010-02-24 | 湖北华中药业有限公司 | Method for synthesizing vitamin B1 derivative dithio-thiamin |
| CN102988300A (en) * | 2012-12-03 | 2013-03-27 | 华中药业股份有限公司 | Thiamine nitrate particle and preparation method thereof |
| CN103720669A (en) * | 2013-11-19 | 2014-04-16 | 华中药业股份有限公司 | Preparation method of compressible vitamin C granules |
| CN103720660A (en) * | 2013-11-19 | 2014-04-16 | 华中药业股份有限公司 | VB2 (vitamin B2) granule and preparation method thereof |
-
2014
- 2014-10-23 CN CN201410567255.6A patent/CN105520841A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85107365A (en) * | 1984-10-09 | 1986-10-01 | 武田药品工业株式会社 | The granule of thiamine salt and production thereof |
| JPH0952832A (en) * | 1995-08-10 | 1997-02-25 | Takeda Chem Ind Ltd | Medicinal composition |
| CN101654440A (en) * | 2009-07-28 | 2010-02-24 | 湖北华中药业有限公司 | Method for synthesizing vitamin B1 derivative dithio-thiamin |
| CN102988300A (en) * | 2012-12-03 | 2013-03-27 | 华中药业股份有限公司 | Thiamine nitrate particle and preparation method thereof |
| CN103720669A (en) * | 2013-11-19 | 2014-04-16 | 华中药业股份有限公司 | Preparation method of compressible vitamin C granules |
| CN103720660A (en) * | 2013-11-19 | 2014-04-16 | 华中药业股份有限公司 | VB2 (vitamin B2) granule and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 崔福德: "《药剂学》", 31 January 2011, 中国医药科技出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104288154B (en) | Favipiravir pharmaceutical composition containing different particle size ranges | |
| CN1360499A (en) | Pharmaceutical composition contg. fenofibrate and preparation method | |
| RU2328134C2 (en) | Feed additive for animals | |
| CN103720660A (en) | VB2 (vitamin B2) granule and preparation method thereof | |
| CN102988993A (en) | Screening and composition of main auxiliary materials of compound acetaminophen tablet, and preparation method of compound acetaminophen tablet | |
| CN102696589B (en) | A kind of flonicamid water dispersible granules and preparation method thereof | |
| CN103099789A (en) | Preparation method of vitamin C granules | |
| HRP20141134T1 (en) | A solid pharmaceutical formulation | |
| CN107951849B (en) | Amlodipine besylate tablet and preparation method thereof | |
| CN103735544B (en) | A kind of preparation technology of vildagliptin/metformin hydrochloride compound preparation | |
| CN105267169A (en) | Rivaroxaban tablet and preparation method thereof | |
| CN105520841A (en) | Thiamine disulfide granules and preparation method thereof | |
| CN104739789B (en) | Pharmaceutical composition containing Solifenacin or its salt | |
| CN105520918B (en) | Pregabalin capsule | |
| CN105434375A (en) | Levetiracetam tablet and preparation method thereof | |
| CN107536831A (en) | A kind of composition and preparation method containing vildagliptin and melbine | |
| CN102274203B (en) | Method for improving moisture resistance of L-carnitine tea polyphenol capsule inclusion | |
| CN103110588A (en) | Production method of vitamin B6 granules | |
| CN107174571A (en) | A kind of Li Gelieting and its salt, ester, the pharmaceutical composition of derivative and preparation method thereof | |
| CN103210913B (en) | Zoxamide water dispersible granule and preparation method thereof | |
| CN107982228B (en) | Dihydroartemisinin tablet and preparation method thereof | |
| CN102428921A (en) | Clodinafop-propargyl water dispersible granule and preparation method thereof | |
| CN107835643A (en) | A kind of novel Zilpaterol animal pre-composition preparation | |
| CN106913556B (en) | Rifapentine capsule and preparation method thereof | |
| CN104138365A (en) | Telmisartan capsule and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Liu Yuting Inventor after: Wang Yong Inventor after: Li Xinyu Inventor after: Wu Shumei Inventor after: Tang Wei Inventor before: Wang Yong Inventor before: Li Xinyu Inventor before: Wu Shumei Inventor before: Tang Wei |
|
| COR | Change of bibliographic data | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160427 |
|
| WD01 | Invention patent application deemed withdrawn after publication |