CN105495564A - Nutritional emulsion, as well as preparation method and application thereof - Google Patents
Nutritional emulsion, as well as preparation method and application thereof Download PDFInfo
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- CN105495564A CN105495564A CN201510506073.2A CN201510506073A CN105495564A CN 105495564 A CN105495564 A CN 105495564A CN 201510506073 A CN201510506073 A CN 201510506073A CN 105495564 A CN105495564 A CN 105495564A
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- oil
- nutrition
- nutrition emulsion
- protein
- emulsion
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
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Abstract
The invention relates to a nutritional emulsion, as well as a preparation method and application thereof. The nutritional emulsion is prepared from grease, water, nutrients, protein and carbohydrate, wherein the grease is 1.0-30.0 percent of the volume of the nutritional emulsion, and water is 70.0-99.0 percent of the volume of the nutritional emulsion; and every 100ml of the nutritional emulsion comprises 0.005-1.0g of nutrients, 0.1-10.0g of protein and 0.1-40.0g of carbohydrate. The nutritional emulsion has excellent freeze-thaw stability, has a relatively good protecting effect for nutrients, and has the advantages of convenience in use, safety, no toxicity, absorption benefit and the like; and the preparation method has the advantages of simple operation and controllable process parameters, is economical and feasible, and is suitable for industrial production.
Description
Technical field
The present invention relates to nutraceutical field, particularly relate to a kind of nutrition emulsion and its preparation method and application.
Background technology
Along with the high development of modern society, nutrient plays more and more important effect in prevent disease and treatment chronic disease, but the defects such as solubility is low, chemically unstable is easily degraded that some nutrient exists, limit its extensive use at food nutrition replenishers and field of medicaments.In order to improve solubility and the biological effectiveness of nutrient, the research of nutritional preparation technology as bag year fat soluble nutrient such as nano-dispersed body technique, solid lipid nano granule technology, microemulsion technology, nano-emulsion technology is adopted to become the focus of research, but, some preparation is needing with an organic solvent or high concentration synthesis class surfactant in preparation, in the Results of nutritional supplementation and chronic disease, all may there is potential safety hazard.
Emulsion comprises water-oil phase, and it can improve oral administration biaavailability with lipid, be easy to the advantages such as industrialization becomes a kind of emulsification system having prospect.In recent years, also have a lot about how improving probing into of fat soluble nutrient retention rate in emulsion systems, such as: utilize Maillard reaction, protein and reproducibility carbohydrate chemical bond is adopted to generate graft copolymer, improve protein emulsifying activity and improve the embedding effect to nutrient, but Maillard reaction research is still immature, in course of reaction, there is the shortcoming that should not control reaction site and reaction time; Utilize electrostatic adsorption, adopt the albumen of oppositely charged can form Non-covalent binding thing with sugar and reach the object protecting nutrient, but Electrostatic Absorption makes Charge repulsion weaken causes instability, and not all polysaccharide and albumen are all with qualified electric charge; Add the antioxidant of synthesis class, unstable nutrient can be protected well, but there is larger potential safety hazard in the antioxidant of synthesis class.In addition, the emulsion only prepared using albumen as stabilizing agent can not tolerate cryogenic conditions, and storage stability is undesirable.
Summary of the invention
Based on this, be necessary the nutrient retention rate for emulsion systems and the dissatisfactory defect of stability, a kind of nutrition emulsion and its preparation method and application is provided.
An object of the present invention is to provide a kind of nutrition emulsion.
Concrete technical scheme is as follows:
A kind of nutrition emulsion, primarily of grease, water, nutrient, protein, carbohydrate composition, wherein:
The volume fraction of described grease in described nutrition emulsion is 1.0-30.0%, and the volume fraction of described water in described nutrition emulsion is 70.0-99.0%;
Containing described nutrient 0.005-5.0g, described protein 0.1-10.0g, described carbohydrate 0.1-40.0g in every 100 milliliters of described nutrition emulsions;
Described nutrient is one or more in fat soluble nutrient;
Described grease is selected from one or more in soybean oil, peanut oil, sesame oil, Seabuckthorn Oil, sunflower oil, linseed oil, perilla oil, coconut oil, olive oil, cod-liver oil, medium chain fatty acid ester;
Described protein is selected from one or more in lactalbumin, albumen, beta lactoglobulin, soybean protein isolate, lactoferrin, whey isolate protein, casein and caseinate;
Described carbohydrate is selected from one or more in glucose, sucrose, trehalose, maltodextrin, maltose, starch, lactose, stevia rebaudianum polysaccharide, oligomeric maltose.
Wherein in some embodiments, the volume fraction of described grease in described nutrition emulsion is 3.0-20.0%, and the volume fraction of described water in described nutrition emulsion is 80.0-97.0%.
Wherein in some embodiments, containing described protein 1.0-5.0g in every 100 milliliters of described nutrition emulsions.
Wherein in some embodiments, containing described carbohydrate 5.0-20.0g in every 100 milliliters of described nutrition emulsions.
Wherein in some embodiments, described fat soluble nutrient is liposoluble vitamin or carotenoid, and liposoluble vitamin is VitAVitE, vitamin D such as, and carotenoid is lutein, carrotene, lycopene such as.
Another object of the present invention is to provide a kind of above-mentioned nutrition emulsion and is preparing the application in health food, beverage, clinical nutritive preparations, medicine.
Concrete technical scheme is as follows:
A kind of above-mentioned nutrition emulsion is preparing the application in health food, beverage/food, clinical nutritive preparations, medicine.
Another object of the present invention is to provide a kind of preparation method of above-mentioned nutrition emulsion.
Concrete scheme is as follows:
A preparation method for nutrition emulsion, comprises the following steps:
(1) by proteolytic abundant aquation in water, obtain protein aqueous solution, then carbohydrate is dissolved in protein aqueous solution, obtain aqueous phase solution;
(2) nutrient is dissolved in grease, obtains oil-phase solution;
(3) oil-phase solution is mixed with aqueous phase solution shear and form thick breast;
(4) emulsifying homogeneous is carried out to thick breast.
Wherein in some embodiments, in described step (1), the time of aquation is 1-24h; The temperature of dissolving in described step (2) is 25-180 DEG C, and the time of dissolving is 1-50min; The speed sheared in described step (3) is 100-30000r/min, and the time of shearing is 30s-10min; In described step (4), the pressure of homogeneous is 200-1500bar, and the cycle-index of homogeneous is 2-15 time.
Wherein in some embodiments, the speed sheared in described step (3) is 1000-10000r/min, and the time of shearing is 30s-5min.
Wherein in some embodiments, in described step (4), the pressure of homogeneous is 300-700bar.
A kind of nutrition emulsion provided by the present invention, is a kind of safe nutrition emulsion that inventor is prepared by a large amount of experiments, and determines its best composition and content.In best composition and content range; and under the cooperation of grease and water; protein and carbohydrate act synergistically mutually; make this nutrition emulsion have good stability, low temperature is placed the wild effects such as rear agalasisa is analysed, layering, flocculation for a long time and is occurred, without bad smell; it is the emulsion droplet of 100-500nm in system; dispersed, low viscosity, to the protective capability of nutrient and freeze-thaw stability splendid.In addition, because this emulsion system is without the need to additionally adding any emulsifying agent and chemical synthesis kind antioxidant, also without the need to adjusting the pH of product, carbohydrate supplementation while supplementary protein and nutrient, realize protein, carbohydrate, fatty three macro-energy supplement, therefore there is safety non-toxic, be beneficial to the feature of absorption.
The preparation method of above-mentioned nutrition emulsion provided by the present invention, without the need to additionally adding any chemical synthesis class emulsifying agent and antioxidant, also without the need to adjusting pH, have easy and simple to handle, technological parameter is controlled, economy and facility, be applicable to the advantage of suitability for industrialized production.
Accompanying drawing explanation
Fig. 1 is the emulsion (A) of fresh preparation in embodiment 1 and the grading curve figure of the storage emulsion (B) of 3 months;
The viscosity of the nutrition emulsion of Fig. 2 obtained by embodiment 2 and shear rate curve figure (sugary quality is A=10g, B=20g, C=30g, D=40g);
The nutrition emulsion of Fig. 3 obtained by embodiment 3 is with the changing trend diagram of ionic strength;
The freeze-thaw stability variation diagram of the nutrition emulsion of Fig. 4 A obtained by embodiment 6;
The freeze-thaw stability variation diagram of the nutrition emulsion of Fig. 4 B obtained by embodiment 4;
The trimestral storage stability variation diagram of the nutrition emulsion low-temperature dark of Fig. 5 obtained by embodiment 5;
The nutrition emulsion low-temperature dark trimestral nutrient retention rate variation diagram of Fig. 6 obtained by embodiment 5;
The grading curve figure of the emulsion (B) that Fig. 7 is the fresh preparation of embodiment 6 and the storage emulsion (A) of 3 months;
The nutrition emulsion low-temperature dark trimestral nutrient retention rate variation diagram of Fig. 8 obtained by embodiment 6.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further elaborated.
Embodiment 1
A kind of nutrition emulsion, is prepared from by following raw material:
The preparation method of above-mentioned nutrition emulsion comprises the following steps:
(1) by whey isolate protein dispersing and dissolving in ultra-pure water, the abundant aquation 1h of normal temperature magnetic agitation, obtains protein aqueous solution, adds trehalose stirring and dissolving, obtains aqueous phase solution;
(2) vitamin A is dissolved 1min in 25 DEG C of perilla oils;
(3) oil-phase solution and aqueous phase solution are stirred and evenly mixed, be high speed shear dispersion 30s under the condition of 8000r/min in rotating speed, obtain thick breast;
(4) by high-pressure homogeneous for thick breast, the cycle-index of homogeneous is 10 times, and homogenization pressure is 700bar, prepares nutrition emulsion.
Prepared nutrition emulsion detects through nano-particle size analysis instrument, detection method for by be put in after Sample Dilution 200 times balance 120s in sample detection pond after detect, at least scanning obtains grading curve 20 times, result as shown in Figure 1, the average grain diameter of emulsion is approximately 260nm, and polydispersity coefficient pdI is less than 0.2, and after this emulsion systems low-temperature dark is placed 3 months, average grain diameter is without marked change, and the nutrition emulsion prepared by explanation is dispersed and have good stability.
Embodiment 2
A kind of nutrition emulsion, is prepared from by following raw material:
The quality A value of sucrose is respectively 10g, 20g, 30g, 40g;
The preparation method of above-mentioned nutrition emulsion comprises the following steps:
(1) by casein dispersing and dissolving in ultra-pure water, the abundant aquation 12h of normal temperature magnetic agitation, obtains protein solution, then adds carbohydrate stirring and dissolving, obtains aqueous phase solution;
(2) lycopene is dissolved in medium chain triglyceride and soybean oil, at 150 DEG C, dissolves 5min, be more at room temperature stirred to whole dissolving, obtain oil-phase solution;
(3) oil-phase solution and aqueous phase solution are stirred and evenly mixed, be that under the condition of 10000r/min, speed shears dispersion 5min in rotating speed, obtain thick breast;
(4) by high-pressure homogeneous for thick breast, the cycle-index of homogeneous is 2 times, and homogenization pressure is 700bar, prepares nutrition emulsion.
Prepared nutrition emulsion detects through Malvern rotational rheometer, and to reach balance, measuring temperature constant was 25 DEG C, and shear rate is 10s in five minutes about 1ml emulsion sample to be put in preheating on cone-plate
-1-1000s
-1as shown in Figure 2, the nutrition emulsion system viscosity obtained is lower than 5mpa.s, and viscosity does not change with the change of shear rate for result, illustrate that this nutrition emulsion is low viscosity Newtonian fluid, the tube feed that can be applicable to patient with severe symptoms or the crowd needing the special diet modes such as slop to take food.
Embodiment 3
A kind of nutrition emulsion, is prepared from by the raw material of following mass percent:
The preparation method of above-mentioned nutrition emulsion comprises the following steps:
(1) by soybean protein isolate and casein dispersing and dissolving in water, the abundant aquation 20h of normal temperature magnetic agitation, obtains protein solution, then adds carbohydrate stirring and dissolving, obtains aqueous phase solution;
(2) vitamin E is dissolved in olive oil and soybean oil, dissolves completely at 80 DEG C, obtain oil-phase solution;
(3) oil-phase solution and aqueous phase solution being stirred and evenly mixed, is under the condition of 1000r/min in rotating speed, and high speed shear dispersion 3min, obtains thick breast;
(4) by high-pressure homogeneous for thick breast, the cycle-index of homogeneous is 15 times, and homogenization pressure is 300bar, prepares nutrition emulsion.
The sodium chloride solution of variable concentrations gradient under preparation neutral environment, the nutrition emulsion of above-mentioned preparation is mixed with sodium chloride solution, preparing containing Na ion concentration scope is the emulsion of 0.2M-4M scope, concussion mixing, low temperature places equilibrate overnight, particle diameter current potential and the coefficient of dispersion is detected with Malvern laser particle analyzer, put into after the emulsion of emulsion different ionic strength is diluted corresponding multiple after droplet measurement instrument sample cell balances 120s and detect, result as shown in Figure 3, find that this nutrition emulsion can tolerate the high salt concentration up to 2M, nutrition emulsion prepared by explanation is under high salt concn stablized, therefore can supplement with high salt food is composite.
Embodiment 4
A kind of nutrition emulsion, is prepared from by the raw material of following mass percent:
The preparation method of above-mentioned nutrition emulsion comprises the following steps:
(1) by soybean protein isolate dispersing and dissolving in ultra-pure water, the abundant aquation 1h of normal temperature magnetic agitation, obtains protein aqueous solution, adds maltodextrin stirring and dissolving, obtains aqueous phase solution;
(2) lutein is dissolved in 25 DEG C of linseed oil and dissolves 5min; ,
(3) oil-phase solution and aqueous phase solution are stirred and evenly mixed, be high speed shear dispersion 30s under the condition of 5000r/min in rotating speed, obtain thick breast;
(4) by high-pressure homogeneous for thick breast, the cycle-index of homogeneous is 5 times, and homogenization pressure is 500bar, prepares nutrition emulsion.
48h placed by the refrigerator nutrition emulsion of above-mentioned fresh preparation being positioned over-20 DEG C, and this is a freezing and thawing cycle, in triplicate, and without freeze thawing in contrast.As shown in fig. 4b, decentralized analysis of stability analyzer is adopted to detect, sample is positioned over highly for behind the transparent sample pond of 45mm, observe the changing value of the backing strip from container bottom to container top, result shows, and after three Frozen-thawed cycled, the changing value of backscattered light is still close to 0 value, illustrate that the freeze-thaw stability of emulsion is good, comparatively extreme low temperature environment can be tolerated.
Embodiment 5
A kind of nutrition emulsion, is prepared from by the raw material of following mass percent:
The preparation method of above-mentioned nutrition emulsion comprises the following steps:
(1) by casein and whey isolate protein dispersing and dissolving in ultra-pure water, the abundant aquation 4h of normal temperature magnetic agitation, obtains protein aqueous solution, adds oligomeric maltose and dissolves and obtain aqueous phase solution completely;
(2) beta carotene is dissolved in soybean oil, dissolves 2min prior to 50 DEG C, then in stirred at ambient temperature until all dissolve;
(3) oil-phase solution and aqueous phase solution are stirred and evenly mixed, be high speed shear dispersion 2min under the condition of 10000r/min in rotating speed, obtain thick breast;
(4) by high-pressure homogeneous for thick breast, the cycle-index of homogeneous is 5 times, and homogenization pressure is 600bar, prepares nutrition emulsion.
The nutrition emulsion of above-mentioned fresh preparation is placed 3 months in low-temperature dark, by decentralized analysis of stability analyzer test specimens product stability, sample is positioned over highly for behind the transparent sample pond of 45mm, the backing strip of observation from container bottom to container top and the change of transmitted light, result as shown in Figure 5, the backscattered light of the nutrition emulsion after placement is almost identical with the nutrition emulsion of fresh preparation with projection light curve, illustrate that the wild effects such as nutrition emulsion provided by the present invention there is no layering, flocculation, breast are analysed, precipitation occur, storage stability is excellent.
The beta carotene that the extracts degradation rate with the storage time is measured with high performance liquid chromatograph; result as shown in Figure 6; the retention rate of the beta carotene retention rate after three months shelf lifes is higher than 90%; illustrate that the protective effect of nutrition emulsion provided by the present invention to nutrient is splendid, nutrient chemical stability in this emulsion systems is excellent.
Embodiment 6
A kind of nutrition emulsion, is prepared from by the raw material of following mass percent:
The preparation method of above-mentioned nutrition emulsion comprises the following steps:
(1) by casein dispersing and dissolving in ultra-pure water, the abundant aquation 4h of normal temperature magnetic agitation, obtains protein aqueous solution;
(2) beta carotene is dissolved in soybean oil, dissolves 2min prior to 50 DEG C, then in stirred at ambient temperature until all dissolve;
(3) oil-phase solution and aqueous phase solution are stirred and evenly mixed, be high speed shear dispersion 2min under the condition of 10000r/min in rotating speed, obtain thick breast;
(4) by high-pressure homogeneous for thick breast, the cycle-index of homogeneous is 5 times, and homogenization pressure is 600bar, prepares nutrition emulsion.
Prepared nutrition emulsion detects through nano-particle size analysis instrument, detection method for by be put in after Sample Dilution 200 times balance 120s in sample detection pond after detect, at least scanning obtains grading curve 20 times, as shown in Figure 7, emulsion is being bimodal distribution to result, and particle diameter is larger, and after this emulsion systems low-temperature dark is placed 3 months, polydispersity coefficient increases, and the nutrition emulsion generation clustering phenomena prepared by explanation, physical stability is bad.
48h placed by the refrigerator nutrition emulsion of above-mentioned fresh preparation being positioned over-20 DEG C, and this is a freezing and thawing cycle, in triplicate, and without freeze thawing in contrast.As shown in fig 4, decentralized analysis of stability analyzer is adopted to detect, sample is positioned over highly for behind the transparent sample pond of 45mm, observe the changing value of the backing strip from container bottom to container top, result shows, after three Frozen-thawed cycled, be scattered light and occur larger fluctuation, there is the wild effects such as obvious layering in sample, illustrates that the freeze-thaw stability of emulsion is not good, can not tolerate comparatively extreme low temperature environment.
The beta carotene that the extracts degradation rate with the storage time is measured with high performance liquid chromatograph; result as shown in Figure 8; the retention rate of retention rate after three months shelf lifes of beta carotene obviously declines, and illustrates that this formula is not good to nutrient protective capability.
Each technical characteristic of the above embodiment can combine arbitrarily, for making description succinct, the all possible combination of each technical characteristic in above-described embodiment is not all described, but, as long as the combination of these technical characteristics does not exist contradiction, be all considered to be the scope that this description is recorded.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be construed as limiting the scope of the patent.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. a nutrition emulsion, is characterized in that, primarily of grease, water, nutrient, protein, carbohydrate composition, wherein:
The volume fraction of described grease in described nutrition emulsion is 1.0-30.0%, and the volume fraction of described water in described nutrition emulsion is 70.0-99.0%;
Containing described nutrient 0.005-5.0g, described protein 0.1-10.0g, described carbohydrate 0.1-40.0g in every 100 milliliters of described nutrition emulsions;
Described nutrient is one or more in fat soluble nutrient;
Described grease is selected from one or more in soybean oil, peanut oil, sesame oil, Seabuckthorn Oil, sunflower oil, linseed oil, perilla oil, coconut oil, olive oil, cod-liver oil, medium chain fatty acid ester;
Described protein is selected from one or more in lactalbumin, albumen, beta lactoglobulin, soybean protein isolate, lactoferrin, whey isolate protein, casein and caseinate;
Described carbohydrate is selected from one or more in glucose, sucrose, trehalose, maltodextrin, maltose, starch, lactose, stevia rebaudianum polysaccharide, oligomeric maltose.
2. nutrition emulsion according to claim 1, is characterized in that, the volume fraction of described grease in described nutrition emulsion is 3.0-20.0%, and the volume fraction of described water in described nutrition emulsion is 80.0-97.0%.
3. nutrition emulsion according to claim 1 and 2, is characterized in that, containing described protein 1.0-5.0g in every 100 milliliters of described nutrition emulsions.
4. nutrition emulsion according to claim 1 and 2, is characterized in that, containing described carbohydrate 5.0-20.0g in every 100 milliliters of described nutrition emulsions.
5. nutrition emulsion according to claim 1 and 2, is characterized in that, described fat soluble nutrient is liposoluble vitamin or carotenoid.
6. the nutrition emulsion described in any one of claim 1-5 is preparing the application in health food, beverage/food, clinical nutritive preparations, medicine.
7. the preparation method of the nutrition emulsion described in any one of claim 1-5, is characterized in that, comprises the following steps:
(1) by proteolytic abundant aquation in water, obtain protein aqueous solution, then carbohydrate is dissolved in protein aqueous solution, obtain aqueous phase solution;
(2) nutrient is dissolved in grease, obtains oil-phase solution;
(3) oil-phase solution is mixed with aqueous phase solution shear and form thick breast;
(4) emulsifying homogeneous is carried out to thick breast.
8. the preparation method of nutrition emulsion according to claim 7, is characterized in that, in described step (1), the time of aquation is 1-24h; The temperature of dissolving in described step (2) is 25-180 DEG C, and the time of dissolving is 1-50min; The speed sheared in described step (3) is 100-30000r/min, and the time of shearing is 30s-10min; In described step (4), the pressure of homogeneous is 200-1500bar, and the cycle-index of homogeneous is 2-15 time.
9. the preparation method of nutrition emulsion according to claim 8, is characterized in that, the speed sheared in described step (3) is 1000-10000r/min, and the time of shearing is 30s-5min.
10. the preparation method of nutrition emulsion according to claim 8, is characterized in that, in described step (4), the pressure of homogeneous is 300-700bar.
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| CN106616987A (en) * | 2016-12-21 | 2017-05-10 | 中山大学 | Nutritional emulsion as well as preparation method and application thereof |
| CN107594503A (en) * | 2017-09-11 | 2018-01-19 | 广东省农业科学院蚕业与农产品加工研究所 | A kind of application of complex enzyme nutrition emulsion and preparation method thereof and complex enzyme |
| CN108497250A (en) * | 2018-03-28 | 2018-09-07 | 北京海生泰合医药科技有限公司 | A kind of the lactalbumin sports drink and production technology of MCT reinforcings |
| CN108578365A (en) * | 2018-05-22 | 2018-09-28 | 潍坊医学院 | A kind of astaxanthin enteral nutrition emulsion, dried emulsifier and its preparation method and application |
| CN114680325A (en) * | 2022-04-25 | 2022-07-01 | 武汉星辰现代生物工程有限公司 | Beta-carotene nanoemulsion and preparation method and application thereof |
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| CN106616987A (en) * | 2016-12-21 | 2017-05-10 | 中山大学 | Nutritional emulsion as well as preparation method and application thereof |
| CN107594503A (en) * | 2017-09-11 | 2018-01-19 | 广东省农业科学院蚕业与农产品加工研究所 | A kind of application of complex enzyme nutrition emulsion and preparation method thereof and complex enzyme |
| CN107594503B (en) * | 2017-09-11 | 2020-12-15 | 广东省农业科学院蚕业与农产品加工研究所 | Complex enzyme nutrient emulsion, preparation method thereof and application of complex enzyme |
| CN108497250A (en) * | 2018-03-28 | 2018-09-07 | 北京海生泰合医药科技有限公司 | A kind of the lactalbumin sports drink and production technology of MCT reinforcings |
| CN108578365A (en) * | 2018-05-22 | 2018-09-28 | 潍坊医学院 | A kind of astaxanthin enteral nutrition emulsion, dried emulsifier and its preparation method and application |
| CN114680325A (en) * | 2022-04-25 | 2022-07-01 | 武汉星辰现代生物工程有限公司 | Beta-carotene nanoemulsion and preparation method and application thereof |
| CN114680325B (en) * | 2022-04-25 | 2022-11-11 | 武汉星辰现代生物工程有限公司 | Beta-carotene nanoemulsion and preparation method and application thereof |
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