CN105477769A - Stem cell introduction device - Google Patents
Stem cell introduction device Download PDFInfo
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- CN105477769A CN105477769A CN201410469951.3A CN201410469951A CN105477769A CN 105477769 A CN105477769 A CN 105477769A CN 201410469951 A CN201410469951 A CN 201410469951A CN 105477769 A CN105477769 A CN 105477769A
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- stem cell
- trocar sheath
- closing member
- nook closing
- hollow
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Abstract
The invention discloses a stem cell introduction device. The stem cell introduction device comprises a hollow outer cannula, a hollow needle core and a hollow catheter. A vernier is arranged along one side on the outer wall of the outer cannula. The other side of the outer wall of the hollow outer cannula is provided with digit scale marks protruding from the outer wall surface. When moving to the digit scale mark, the vernier is rotated to be secured between digit scale marks or above them. The head of the needle core is provided with a piercing part. The tail of the needle core is connected with one end of a first injector joint. The piercing part is exposed by two millimeters when the needle core is completely inserted into the hollow part of the outer cannula. The near end of the cannula is connected to the other end of the first injector joint. The distal end of the cannula is connected to a second injector joint. The stem cell introduction device has following beneficial effects: the stem cell introduction device can accurately introduce stem cells into the stratum basale of the endometrium such that the damaged endometrium of a patient can be repaired; the reproduction function is improved so that diseases related to endometria can be treated; and the stem cell introduction device is easy and convenient to operate, cost-effective and practical and is convenient for clinic use.
Description
Technical field
The present invention relates to a kind of stem cell gatherer, particularly relate to a kind of by the gatherer of stem cell or drugs delivery basal layer.
Background technology
Endometrium increases organ the most active in human body, is divided into functional layer and basal layer, and the former with Estrogen and progestin change in menstrual cycle, propagation occurs and changes with secretion; Latter wound repairing, hypertrophy after menstrual phase inner membrance comes off form new functional layer.The driving source of this repair process of menstrual endometrium wound surface is the stem cell being positioned at inner membrance basal layer.Thought that the damage and fracture of basal layer was irreversible pathological changes in the past, patient's amenorrhea and infertile can be caused.Zoopery is by stem cell injection to myometrium and inner membrance intersection, and visible damage position has new inner membrance to be formed.Stem cell, as the pluripotent cell with self replication and directed differentiation ability, opens the new approaches of mankind's difficult and complicated illness treatment., the clinical difficult disease such as intimal lesion or damage excessively thin to endometrium in department of obstetrics and gynecology field, adopting stem cell local to import is the new therapeutic means improved inner membrance local environment, impel interior film healing, need clinically to solve method stem cell being imported to inner membrance basal layer, but how stem cell being sent to lesion is still an open question.
Summary of the invention
For the problems referred to above, the technical problem that the present invention mainly solves is to provide a kind of stem cell gatherer, stem cell can be imported endometrial basal layer by described stem cell gatherer exactly, thus the inner membrance making patient impaired is repaired, improve reproductive function, membrane disease in treatment, described stem cell gatherer is easy and simple to handle, economical and practical, is convenient to clinical expansion.
For solving the problems of the technologies described above, the technical solution used in the present invention is: provide a kind of stem cell gatherer, and described gatherer comprises the conduit of the trocar sheath of hollow, the nook closing member of hollow and hollow;
The side of described trocar sheath outer wall is provided with the vernier that can move up and down along described trocar sheath outer wall, the opposite side of described trocar sheath outer wall for zero point is to having the digital calibration labelling protruding from outer wall surface with described trocar sheath top, rotates described vernier and makes described vernier be fixed on described digital calibration labelling when described vernier moves to described digital calibration mark;
The head end of described nook closing member is provided with sharp portion, and described nook closing member tail end connects one end of the first syringe interface, and when described nook closing member inserts the hollow bulb of described trocar sheath completely, described sharp portion exposes described trocar sheath two millimeters;
The near-end of described conduit connects the other end of the first syringe interface, and the far-end of described conduit connects the second syringe interface.
Stem cell gatherer using method of the present invention is: (1) is first by the probe detection uterine cavity degree of depth, again by probe and trocar sheath comparison, the uterine cavity degree of depth detected by probe carrys out moving cursor to respective digital scale mark place, again by clockwise or be rotated counterclockwise 90o ~ 180o rotating vernier, vernier is fixed between digital calibration labelling or on digital calibration labelling; (2) nook closing member is inserted the hollow bulb of trocar sheath, retreating nook closing member makes sharp portion retreat to completely in the hollow bulb of trocar sheath, trocar sheath is inserted in uterine cavity again through cervix uteri mouth, nook closing member tail end is communicated with catheter proximal end by the first syringe interface, the second syringe interface that distal end of catheter connects connects the syringe that stem cell liquid or medicinal liquid are housed; (3) vernier reaches cervical orifice place, the top of trocar sheath is touched at the bottom of palace just, fixed jacket pipe, core of above pushing pin makes nook closing member enter trocar sheath completely, and now sharp portion thrusts Uterus wall two millimeters, push a little stem cell liquid, after exiting nook closing member, move trocar sheath, fixed jacket pipe respectively to the angular direction, left and right palace of uterine cavity and front and rear wall, core of pushing pin again makes sharp portion thrust Uterus wall two millimeters and inject stem cell liquid, multi-point injection Cell sap in Uterus wall like this.Stem cell gatherer of the present invention controls syringe needle and thrusts Uterus wall two millimeters, this degree of depth is just myometrium and inner membrance boundary aspect, i.e. place, basal layer position, through multi-point injection, import the stem cell survival near inner membrance basal layer, under local environmental factors effect, play differentiation potential, form inner membrance glandular epithelium and mesenchymal cell, the cell that each injection point is newly bred simultaneously spreads towards periphery, connects and is the new functional layer formed in flakes.
Preferably, described trocar sheath is the blunt smooth straight tube of nose-circle.The nose-circle of trocar sheath is blunt smooth, not easy damaged uterine cavity mucosal tissue when trocar sheath is inserted in uterine cavity; Trocar sheath is straight tube, and the uterus being suitable for horizontal position uses.
Preferably, described trocar sheath is the bend pipe of blunt smooth, the front curvature of nose-circle.The nose-circle of trocar sheath is blunt smooth, not easy damaged uterine cavity mucosal tissue when trocar sheath is inserted in uterine cavity; Trocar sheath front curvature, is suitable for anteflexion position or rear uterus of bending position and uses.
Preferably, described sharp portion is 45 degree of inclined-planes.Sharp portion is 45 degree of inclined-planes, makes nook closing member sharp-pointed, easily thrusts Uterus wall.
Preferably, described conduit is set to breeches pipe.Conduit is set to breeches pipe, the supervisor of breeches pipe near-end is communicated with the other end of the first syringe interface, two side pipes of breeches pipe far-end connect second syringe interface respectively, the second syringe interface connect respectively the syringe that stem cell liquid and medicinal liquid are housed.When using stem cell gatherer of the present invention to inject stem cell toward Uterus wall, folder closes the side pipe of the breeches pipe of logical medicinal liquid, after stem cell multi-point injection, change the side pipe that folder closes the breeches pipe of logical stem cell liquid into, decontrol the side pipe of the breeches pipe of logical medicinal liquid, nook closing member thrusts Uterus wall, injects a little medicinal liquid, makes the stem cell liquid retained in syringe needle inject Uterus wall.
Preferably, described digital calibration labelling is with described trocar sheath top for zero point, and often downward 0.5 centimetre is provided with a described digital calibration labelling, until 9 centimeters.From the top on trocar sheath top, arrange a digital scale mark every 0.5 centimetre, totally 9 centimeter length, this sets according to the mean depth of people's uterine cavity.
Preferably, described trocar sheath is straight pipe, thickness of pipe wall 1.0 millimeters, external diameter 5.5 millimeters, long 15 centimetres.This is according to the mean depth of people's uterine cavity and reduces and set the length of trocar sheath, external diameter and shape to the infringement of cervix uteri mouth.
Preferably, described nook closing member is straight pipe, external diameter 3 millimeters, internal diameter 1 millimeter, long 15.2 centimetres, near head end 0.5 cm OD constriction to 1.5 mm dia.This sets the length of nook closing member and inside and outside footpath according to trocar sheath length and internal diameter, is convenient to the sharp portion of nook closing member when nook closing member inserts the hollow bulb of trocar sheath completely and exposes trocar sheath two millimeters.
Preferably, described conduit is silica gel hose, external diameter 3 millimeters, internal diameter 1 millimeter, long 4 centimetres.This is the inside and outside footpath setting conduit according to the inside and outside footpath of nook closing member, and nook closing member and conduit are cooperatively interacted; Conduit is silica gel hose, and silica gel is nontoxic, and is convenient to folder and closes conduit.
Preferably, described trocar sheath is made up of medical poisonless hard plastic material, and described nook closing member is that metal material is made.Trocar sheath is made up of medical poisonless hard plastic material, reduces the murder by poisoning to uterus when trocar sheath is inserted in uterine cavity; Nook closing member is that metal material is made, and make nook closing member have certain hardness, the sharp portion being convenient to nook closing member thrusts Uterus wall.
Be different from and existingly not yet solve situation stem cell being imported basal layer, stem cell gatherer of the present invention makes trocar sheath insert in uterine cavity by the digital calibration labelling of trocar sheath and cooperatively interacting of vernier, when vernier reaches cervical orifice place, the top of trocar sheath is touched at the bottom of palace just, determine the position of trocar sheath in this way dexterously, owing to determining to make the sharp portion of nook closing member head end thrust Uterus wall just in time two millimeters in the position of trocar sheath when again nook closing member being inserted completely the hollow bulb of described trocar sheath, this degree of depth is just myometrium and inner membrance boundary aspect, i.e. place, basal layer position, finally inject stem cell by conduit and nook closing member to Uterus wall by the syringe that stem cell liquid is housed, stem cell is injected into basal layer exactly, thus the inner membrance making patient impaired is repaired, improve reproductive function, membrane disease in treatment.In addition, stem cell gatherer of the present invention is easy and simple to handle, economical and practical, is convenient to clinical expansion.
Accompanying drawing explanation
The stem cell gatherer sectional view that Fig. 1 provides for the embodiment of the present invention;
The stem cell gatherer sectional view that Fig. 2 provides for another embodiment of the present invention.
Detailed description of the invention
Below in conjunction with drawings and Examples, the present invention is described in detail.
Embodiment 1
Refer to Fig. 1, stem cell gatherer comprises the conduit 3 of the trocar sheath 1 of hollow, the nook closing member 2 of hollow and hollow.The blunt smooth straight pipe of nose-circle that trocar sheath 1 is made up of medical poisonless hard plastic material, thickness of pipe wall 1.0 millimeters, external diameter 5.5 millimeters, long 15 centimetres; The side of trocar sheath 1 outer wall is provided with the vernier 101 that can move up and down along trocar sheath 1 outer wall, beyond the opposite side of trocar sheath 1 outer wall cannula tip be zero point often downward 0.5 centimetre to having the digital calibration labelling 102 that protrudes from the outer wall surface of trocar sheath 1, until 9 centimeters, again by clockwise or counterclockwise rotate 90o ~ 180o rotating vernier 101 and make it be fixed on digital calibration labelling 102 when vernier 101 moves to digital calibration labelling 102 place.The straight pipe that nook closing member 2 is made for metal material, external diameter 3 millimeters, internal diameter 1 millimeter, long 15.2 centimetres, near head end 0.5 cm OD constriction to 1.5 mm dia, the head end of nook closing member 2 is provided with sharp portion 201, and sharp portion 201 is in 45 degree of inclined-planes, nook closing member 2 tail end connects one end of the first syringe interface 4, and when nook closing member 2 inserts the hollow bulb of trocar sheath 1 completely, sharp portion 201 exposes 2 millimeters; Conduit 3 is silica gel hose, external diameter 3 millimeters, internal diameter 1 millimeter, and long 4 centimetres, the near-end of conduit 3 connects the other end of the first syringe interface 4, and the far-end of conduit 3 connects the second syringe interface 5.The stem cell gatherer using method of the present embodiment is: (1) is first by the probe detection uterine cavity degree of depth, again by probe and trocar sheath 1 comparison, the uterine cavity degree of depth detected by probe comes moving cursor 101 to respective digital scale mark 102 place, again by rotating 90o ~ 180o rotating vernier 101 clockwise or counterclockwise, vernier 101 is fixed between digital calibration labelling 102 or on digital calibration labelling 102; (2) nook closing member 2 is inserted the hollow bulb of trocar sheath 1, retreating nook closing member 2 makes sharp portion 201 retreat in the hollow bulb of trocar sheath 1 completely, insert in trocar sheath 1 to uterine cavity through cervix uteri mouth again, nook closing member 2 tail end is communicated with conduit 3 near-end by the first syringe interface 4, the second syringe interface 5 that conduit 3 far-end connects connects the syringe that stem cell liquid is housed; (3) vernier 101 reaches cervical orifice place, the top of trocar sheath 1 is touched at the bottom of palace just, fixed jacket pipe 1, core 2 of above pushing pin makes it enter trocar sheath 1 completely, and now sharp portion 201 thrusts Uterus wall 2 millimeters, push a little stem cell liquid, after exiting nook closing member 2, move trocar sheath 1, fixed jacket pipe 1 respectively to the angular direction, left and right palace of uterine cavity and front and rear wall, core 2 of pushing pin again makes sharp portion 201 thrust Uterus wall two millimeters and inject stem cell liquid, multi-point injection stem cell liquid in Uterus wall like this.
Embodiment 2
Refer to Fig. 2, the stem cell gatherer sectional view that Fig. 2 provides for another embodiment of the present invention, trocar sheath in the stem cell gatherer that the present embodiment provides, nook closing member, the trocar sheath of the first syringe interface and the second syringe interface and the stem cell gatherer provided embodiment illustrated in fig. 1, nook closing member, first syringe interface is identical with the second syringe interface, with the stem cell gatherer provided embodiment illustrated in fig. 1 unlike, conduit 3 is set to breeches pipe, the supervisor of breeches pipe near-end is communicated with the other end of the first syringe interface 4, two side pipes of breeches pipe far-end connect second syringe interface 5 respectively, second syringe interface 5 connects respectively the syringe that stem cell liquid and medicinal liquid are housed.The stem cell gatherer using method of the present embodiment is: (1) is first by the probe detection uterine cavity degree of depth, again by probe and trocar sheath 1 comparison, the uterine cavity degree of depth detected by probe comes moving cursor 101 to respective digital scale mark 102 place, again by rotating 90o ~ 180o rotating vernier 101 clockwise or counterclockwise, vernier 101 is fixed between digital calibration labelling 102 or on digital calibration labelling 102; (2) nook closing member 2 is inserted the hollow bulb of trocar sheath 1, retreating nook closing member 2 makes sharp portion 201 retreat in the hollow bulb of trocar sheath 1 completely, insert in trocar sheath 1 to uterine cavity through cervix uteri mouth again, nook closing member 2 tail end is communicated with conduit 3 near-end by the first syringe interface 4, and the second syringe interface 5 that conduit 3 far-end connects connects the syringe that stem cell liquid and medicinal liquid are housed respectively; (3) vernier 101 reaches cervical orifice place, the top of trocar sheath 1 is touched at the bottom of palace just, fixed jacket pipe 1, folder closes the side pipe of the breeches pipe of logical medicinal liquid, on core 2 of pushing pin make it enter trocar sheath 1 completely, now sharp portion 201 thrusts Uterus wall 2 millimeters, push a little stem cell liquid, after exiting nook closing member 2, trocar sheath 1 is moved respectively to the angular direction, left and right palace of uterine cavity and front and rear wall, fixed jacket pipe 1, core 2 of pushing pin again makes sharp portion 201 thrust Uterus wall 2 millimeters and inject stem cell liquid, multi-point injection stem cell liquid in Uterus wall like this; (4) after stem cell multi-point injection, change the side pipe that folder closes the breeches pipe of logical stem cell liquid into, decontrol the side pipe of the breeches pipe of logical medicinal liquid, nook closing member 2 thrusts Uterus wall, injects a little medicinal liquid, makes the stem cell liquid retained in nook closing member 2 inject Uterus wall.
Syringe interface in above-described embodiment can be universal syringe interface.
Stem cell gatherer of the present invention is used to import to basal layer the follicle that time of stem cell should be arranged in non-intermenstrual period menstrual cycle early stage.Now, endometrium is the thinnest and be in the Endometrial stem cell multiplicative stage, and it is high that stem cell imports success rate.After stem cell imports, give exogenous estrogen supporting treatment, promote the hypertrophy and the differentiation that import endometrial stem cell, when B-mode ultrasonography prompting endometrium thickness is greater than 6 ~ 8mm, change estrogen into periodically to use, judge curative effect according to or without withdrawal bleeding and amount of bleeding, if desired, within 3 ~ 6 months, reuse stem cell gatherer of the present invention and import stem cell to basal layer, treat.The hypertrophy high in view of stem cell and reparation potential, imported basal layer and be used for the treatment of the carcinoma of endometrium and precancerous lesion that intrauterine is lepthymenia, inner membrance disease damage is repaired and limit to.Stem cell gatherer of the present invention is applicable to palace wall local injection diagnosis and treatment hysteropathy simultaneously.
Those skilled in the art do not depart from essence of the present invention and spirit, various deformation scheme can be had to realize the present invention, the foregoing is only the better feasible embodiment of the present invention, not thereby interest field of the present invention is limited to, the equivalent structure change that all utilizations description of the present invention and accompanying drawing content are done, is all contained within interest field of the present invention.
Claims (10)
1. a stem cell gatherer, is characterized in that, described gatherer comprises the conduit of the trocar sheath of hollow, the nook closing member of hollow and hollow;
The side of described trocar sheath outer wall is provided with the vernier that can move up and down along described trocar sheath outer wall, the opposite side of described trocar sheath outer wall for zero point is to having the digital calibration labelling protruding from outer wall surface with described trocar sheath top, rotates described vernier and described vernier is fixed between described digital calibration labelling or on described digital calibration labelling when described vernier moves to described digital calibration mark;
The head end of described nook closing member is provided with sharp portion, and described nook closing member tail end connects one end of the first syringe interface, and when described nook closing member inserts the hollow bulb of described trocar sheath completely, described sharp portion exposes described trocar sheath two millimeters;
The near-end of described conduit connects the other end of the first syringe interface, and the far-end of described conduit connects the second syringe interface.
2. stem cell gatherer according to claim 1, is characterized in that, described trocar sheath is the blunt smooth straight tube of nose-circle.
3. stem cell gatherer according to claim 1, is characterized in that, described trocar sheath is the bend pipe of blunt smooth, the front curvature of nose-circle.
4. stem cell gatherer according to claim 1, is characterized in that, described sharp portion is 45 degree of inclined-planes.
5. stem cell gatherer according to claim 1, is characterized in that, described conduit is set to breeches pipe.
6. stem cell gatherer according to claim 1, is characterized in that, described digital calibration labelling is with described trocar sheath top for zero point, and often downward 0.5 centimetre is provided with a described digital calibration labelling, until 9 centimeters.
7. the stem cell gatherer according to any one of claim 1,2,4,5,6, is characterized in that, described trocar sheath is straight pipe, thickness of pipe wall 1.0 millimeters, external diameter 5.5 millimeters, long 15 centimetres.
8. stem cell gatherer according to claim 7, is characterized in that, described nook closing member is straight pipe, external diameter 3 millimeters, internal diameter 1 millimeter, long 15.2 centimetres, near head end 0.5 cm OD constriction to 1.5 mm dia.
9. stem cell gatherer according to claim 8, is characterized in that, described conduit is silica gel hose, external diameter 3 millimeters, internal diameter 1 millimeter, long 4 centimetres.
10. stem cell gatherer according to claim 9, is characterized in that, described trocar sheath is made up of medical poisonless hard plastic material, and described nook closing member is that metal material is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410469951.3A CN105477769B (en) | 2014-09-16 | 2014-09-16 | Stem cell gatherer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410469951.3A CN105477769B (en) | 2014-09-16 | 2014-09-16 | Stem cell gatherer |
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| Publication Number | Publication Date |
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| CN105477769A true CN105477769A (en) | 2016-04-13 |
| CN105477769B CN105477769B (en) | 2019-03-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410469951.3A Active CN105477769B (en) | 2014-09-16 | 2014-09-16 | Stem cell gatherer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107693926A (en) * | 2017-11-08 | 2018-02-16 | 固安博健生物技术有限公司 | A kind of adjustable hysteroscope endometrium injection device |
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| WO2011038931A1 (en) * | 2009-10-01 | 2011-04-07 | B. Braun Melsungen Ag | Catheter insertion device |
| CN202355651U (en) * | 2011-10-26 | 2012-08-01 | 杨月芬 | Safety type puncture injection needle |
| CN202761397U (en) * | 2012-09-19 | 2013-03-06 | 袁源 | Novel brain puncture needle |
| CN203075346U (en) * | 2013-01-16 | 2013-07-24 | 中国医学科学院阜外心血管病医院 | Infant intra-arterial infusion syringe needle |
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Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2116490U (en) * | 1992-03-10 | 1992-09-23 | 南通丝绸印染联合厂 | Syringe having insertion depth controller |
| CN2449667Y (en) * | 2000-11-02 | 2001-09-26 | 张顺遂 | Guide type arc tracheal puncture needle |
| CN201200674Y (en) * | 2008-06-06 | 2009-03-04 | 段希康 | Infusion device |
| CN201290948Y (en) * | 2008-10-15 | 2009-08-19 | 上海市儿童医院 | Mice intrauterine stem cell transplantation tool |
| WO2011038931A1 (en) * | 2009-10-01 | 2011-04-07 | B. Braun Melsungen Ag | Catheter insertion device |
| CN202355651U (en) * | 2011-10-26 | 2012-08-01 | 杨月芬 | Safety type puncture injection needle |
| CN202761397U (en) * | 2012-09-19 | 2013-03-06 | 袁源 | Novel brain puncture needle |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107693926A (en) * | 2017-11-08 | 2018-02-16 | 固安博健生物技术有限公司 | A kind of adjustable hysteroscope endometrium injection device |
| CN107693926B (en) * | 2017-11-08 | 2023-12-01 | 固安博健生物技术有限公司 | Adjustable intrauterine injection device with hysteroscope |
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| Publication number | Publication date |
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| CN105477769B (en) | 2019-03-15 |
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