CN105476636A - Real-time magnetic resonance imaging data collecting and analyzing method and system - Google Patents
Real-time magnetic resonance imaging data collecting and analyzing method and system Download PDFInfo
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Abstract
The invention provides a real-time magnetic resonance imaging data collecting and analyzing method and system. The method comprises the steps that scanning is conducted on a testee, and a magnetic resonance scan image sequence is generated in real time; real-time processing is conducted on the magnetic resonance scan image sequence to obtain scan image data subjected to real-time treatment. The system comprises a magnetic resonance scanning module and a data processing module. According to the real-time magnetic resonance imaging data collecting and analyzing method and system, the magnetic resonance scan image sequence is generated through the magnetic resonance scanning module in real time, the magnetic resonance scan image sequence is transmitted to the data processing module in time so as to enable the data processing module to conduct image processing, and therefore real-time collecting and analyzing of magnetic resonance imaging data are achieved. The real-time magnetic resonance imaging data collecting and analyzing system is stable in framework performance, safe, reliable and strong in expandability. In brain science research, compared with offline function magnetic resonance imaging, the real-time function magnetic resonance imaging is more accurate in feedback regulation mode and better in real-time performance.
Description
Technical field
The present invention relates to mr imaging technique field, particularly relate to a kind of real-time magnetic resonance image-forming data acquisition analytical method and system.
Background technology
Functional MRI (functionalMagneticResonanceImaging, be called for short fMRI) is a kind of emerging neuroimaging mode, and its principle is utilize magnetic to shake hemodynamic change that radiography causes to measure neuron activity.FMRI studies a kind of very effective method of brain function at present, because it can without the signal intensity of the blood oxygen dependence level (BloodOxygenLevelDependent is called for short BOLD) of the whole cerebral nerve activity that sets a record under high spatial resolution.But, the data that traditional functional mri research uses processed offline to gather, data are Using statistics Parameter Map (StatisticalParametricMapping after data acquisition completes only, be called for short SPM), functional nerve image analysing computer (AnalysisofFunctionalNeuroImages, be called for short AFNI) etc. software scan process, calculating etc. are carried out to data, often need the time in several days even a few weeks.In many cases, such as a scan operation person or researcher possibly cannot detect because of technical failure or subjects compliance difference and the problem such as can not to react in time, the result of this dereference data is compared other more interactive imaging techniques and is made using of fMRI and understand more complicated.
In order to overcome the Real-time Obtaining of restricting data, simultaneously also in order to real-time process can be carried out to the data that the experiment of using function mr imaging technique produces, namely realize real-time functional magnetic resonance imaging.A kind of brain-computer interface (BrainComputerInterface is proposed in prior art, be called for short BCI) technology, this technology has very large use in brain science research, compare in traditional experiment of the cognition based on Functional magnetic resonance imaging, brain-computer interface technology can see the gatherer process of scanogram in real time, if there are the problems such as head moves in gatherer process, can at once find and take measures, instead of after will by the time testing end, a couple of days as before, data prediction completes and just pinpoints the problems.In the research of brain-computer interface (BCI) technology, real-time functional magnetic resonance can provide a kind of information reading technology of noninvasive, high spatial resolution for brain-computer interface technical research.Meanwhile, real-time functional magnetic resonance imaging technique has important social value at brain function mechanism, brain perceive in the adjustment of cognitive competence, the disease treatment relevant with cognition etc.But the research based on the real-time functional magnetic resonance imaging online treatment of brain-computer interface is faced with a lot of challenges, be in particular in following some:
1, cannot Real-time Obtaining MR data.In the experiment of traditional function NMR (Nuclear Magnetic Resonance)-imaging, it is very many for being used under similar environment in order to obtain the software of memory scanning image on scanning main frame, these softwares are mostly with digital imaging and communications in medicine (DigitalImagingandCommunicationsinMedicine, be called for short DICOM) based on the image archiving write and communication system (PictureArchivingandCommunicationSystems is called for short PACS) communication software.But these existing softwares do not possess the function of real-time image acquisition in scanning process required by real-time functional magnetic resonance imaging, their function is all after traditional experimentation (scanning process) terminates completely, then downloads the scanning imagery file that scanning main frame has existed;
2, fMRI Signal-to-Noise is low.The noise jamming that nuclear magnetic resonance scanner and physiological movement produce belongs to high-frequency noise more, and physiological movement comprises breathing, heart beating etc., when particularly these are relevant to task, on BOLD signal to detect impact larger, simultaneously, because BOLD effect is blood flow regulation, the change speed of active region signal is limited, physiology spontaneous activity can cause the fluctuation of thermal noise and high temporal frequency, the shakiness of scanning hardware can produce low frequency wonder, thus easily cause fMRI Signal-to-Noise lower, and signal intensity has certain delay relative to real neural activity, certain difficulty is brought to signal processing.And how to remove the interfering signal with BOLD signal correction, improving signal to noise ratio is a major challenge faced;
3, data-handling efficiency is low.The view data that nuclear magnetic resonance scanner produces needs elapsed time layer correction, head dynamic(al) correction, registration, segmentation, standardization, pretreatment and the step such as characteristics extraction, pattern recognition such as level and smooth, and the mode efficiency that tradition single computer carries out date processing is difficult to reach the requirement of real-time fMRI to data-handling efficiency.
Summary of the invention
The object of the present invention is to provide a kind of real-time magnetic resonance image-forming data acquisition analytical method and system, the problem that during in order to solve the real-time functional magnetic resonance imaging online treatment based on brain-computer interface in prior art, fMRI Signal-to-Noise is low and data-handling efficiency is low.
First aspect of the present invention is to provide a kind of real-time magnetic resonance image-forming data acquisition analytical method, comprising:
Subjects is scanned, and generates magnetic resonance imaging image sequence in real time;
Magnetic resonance imaging image sequence is processed in real time, to obtain the scan image data after process in real time.
Further, also comprise: the scan image data after process is showed subjects.
Further, described magnetic resonance imaging image sequence to be processed in real time, comprises with the scan image data after obtaining process in real time:
Pretreatment is carried out to magnetic resonance imaging image sequence, to obtain pretreated magnetic resonance imaging image;
Corresponding target data is extracted according in the algorithm magnetic resonance imaging image after the pre-treatment preset.
Further, carry out pretreated operation to magnetic resonance imaging image sequence to comprise:
Format conversion is carried out to magnetic resonance imaging image sequence;
Magnetic resonance imaging image sequence after format conversion is corrected, standardization and go interference process.
Another aspect of the present invention is to provide a kind of real-time magnetic resonance image-forming data acquisition analytical system, comprising:
Magnetic resonance imaging module, for scanning subjects, and generates magnetic resonance imaging image sequence in real time;
Data processing module, for processing in real time magnetic resonance imaging image sequence, to obtain the scan image data after process in real time.
Further, also comprise display module, for the scan image data after process is showed subjects.
Further, magnetic resonance imaging module comprises magnetic resonance scanner and magnetic resonance imaging main frame, and wherein, magnetic resonance scanner is used for scanning subjects, and generates magnetic resonance imaging image sequence; Magnetic resonance imaging main frame is used for Real-time Obtaining magnetic resonance imaging image sequence.
Further, data processing module comprises pretreatment unit and coupling extraction unit, and wherein, pretreatment unit is used for carrying out pretreatment to magnetic resonance imaging image sequence, to obtain pretreated magnetic resonance imaging image; Coupling extraction unit is used for extracting corresponding target data in the default algorithm of basis magnetic resonance imaging image after the pre-treatment.
Further, pretreatment unit comprises format conversion subelement, syndrome unit, normalizer unit and goes to disturb subelement, and wherein, format conversion subelement is used for carrying out format conversion to magnetic resonance imaging image sequence; Syndrome unit is used for carrying out feature correction to the magnetic resonance imaging image sequence after format conversion; The standard form that normalizer unit is used for according to presetting carries out standardization to the magnetic resonance imaging image sequence after format conversion; Go interference subelement for going interference process to the magnetic resonance imaging image sequence after format conversion.
The beneficial effect of employing the invention described above technical scheme is: generate magnetic resonance imaging image sequence in real time by magnetic resonance imaging module, and timely magnetic resonance imaging image sequence is transferred on data processing module, carry out image procossing for data processing module, thus realize the gather and analysis of real-time magnetic resonance imaging data.Real-time magnetic resonance image-forming data acquisition analytical system framework performance provided by the invention is stable, safe and reliable, extensibility is strong.In brain science research, real-time functional magnetic resonance imaging is compared with offline functionality nuclear magnetic resonance, and its feedback regulation mode is more accurate, real-time is better.To move at the end of a thread in experiment that detections, the research of brain-computer interface technology, brain function are machine-processed, brain perceive all has very important value in the adjustment of cognitive competence, the disease treatment relevant with cognition etc.
Accompanying drawing explanation
Fig. 1 is the schematic flow sheet of real-time magnetic resonance image-forming data acquisition analytical method of the present invention;
Fig. 2 is the structural representation of real-time magnetic resonance image-forming data acquisition analytical system of the present invention;
Fig. 3 is the structural representation of magnetic resonance imaging module in Fig. 2;
Fig. 4 is the structural representation of data processing module in Fig. 2.
Detailed description of the invention
For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with the accompanying drawing in the embodiment of the present invention, technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is the present invention's part embodiment, instead of whole embodiments.
The invention discloses a kind of real-time magnetic resonance image-forming data acquisition analytical method, as shown in Figure 1, can comprise the steps:
Step S101, scans subjects, and generates magnetic resonance imaging image sequence in real time;
Step S102, processes in real time to magnetic resonance imaging image sequence, to obtain the scan image data after process in real time.
In embodiments of the present invention, scanning is carried out to subjects and after in real time generating magnetic resonance imaging image sequence, pretreatment can be carried out to this magnetic resonance imaging image sequence, concrete, comprise and format conversion is carried out to magnetic resonance imaging image sequence and the magnetic resonance imaging image sequence after format conversion is corrected, standardization and go interference process, thus obtain pretreated magnetic resonance imaging image, and then extract corresponding target data according in the algorithm magnetic resonance imaging image after the pre-treatment preset, thus the scan image data obtained after process in real time.In the present embodiment, the scan image data after process can also be showed subjects in real time, thus allow subjects also can the MR data of decorrelation timely.
The invention also discloses a kind of real-time magnetic resonance image-forming data acquisition analytical system, as shown in Figure 2, comprising: magnetic resonance imaging module 200 and data processing module 300, wherein, magnetic resonance imaging module 200, for scanning subjects, and generates magnetic resonance imaging image sequence in real time; Data processing module 300, for processing in real time magnetic resonance imaging image sequence, to obtain the scan image data after process in real time.The present invention generates magnetic resonance imaging image sequence in real time by magnetic resonance imaging module 200, and is transferred on data processing module 300 by magnetic resonance imaging image sequence timely, carries out image procossing for data processing module 300.
In embodiments of the present invention, this system can also comprise display module 400, wherein, can carry out data transmission by TEP/IP agreement, ICP/IP protocol or other similar host-host protocols between display module 400 and data processing module 300, thus the scan image data after data processing module 300 can be processed by display module 400 shows subjects.Concrete, display module 400 can adopt projector to realize.
As shown in Figure 3, magnetic resonance imaging module 200 specifically can also comprise magnetic resonance scanner 201 and magnetic resonance imaging main frame 202, and wherein, magnetic resonance scanner 201 for scanning subjects, and generates magnetic resonance imaging image sequence; The magnetic resonance imaging image sequence that magnetic resonance imaging main frame 202 generates for Real-time Obtaining magnetic resonance scanner 201.
As shown in Figure 4, data processing module 300 specifically can comprise pretreatment unit 301 and coupling extraction unit 302:
In the present embodiment, pretreatment unit 301 can shift to an earlier date file opening and receive service, and define self receive the storing path of file, the application entity title (ApplicationEntityTitle is called for short AET) of transmission, own files receive the network service port, IP network address etc. of serving and using.202, magnetic resonance imaging main frame can by inserting the IP network address of destination host and pretreatment unit 301, network service port, AET and file transmit path, thus send magnetic resonance imaging image sequence in real time to pretreatment unit 301, to make pretreatment unit 301 can carry out pretreatment to the magnetic resonance imaging image sequence received, thus obtain pretreated magnetic resonance imaging image.Concrete, pretreatment unit 301 also comprises format conversion subelement 3011, syndrome unit 3012, normalizer unit 3013 and goes to disturb subelement 3014, wherein, format conversion subelement 3011 is for carrying out format conversion to magnetic resonance imaging image sequence, namely pass through inner gigabit networking with the magnetic resonance imaging image sequence of DICOM Data Transport Protocol Real-time Obtaining magnetic resonance imaging main frame 202, and magnetic resonance imaging image sequence is converted to the three-dimensional image matrix file of subsequent treatment needs; Syndrome unit 3012 is for carrying out feature correction to the magnetic resonance imaging image sequence after format conversion subelement 3011 format conversion, namely when extraction of magnetic resonance scanner 201 scanogram gathers, the head of subjects moves parameter, thus utilizes these parameters to carry out registration to magnetic resonance imaging image sequence; Normalizer unit 3013 is for carrying out standardization according to the standard form preset to the magnetic resonance imaging image sequence after format conversion; Go interference subelement 3014 for going interference process to the magnetic resonance imaging image sequence after format conversion, specifically can be called the business softwares such as SPM, AFNI by script automatically to have processed, thus noise when reducing magnetic resonance data acquisition and the interference of other factors.
Coupling extraction unit 302 is for extracting corresponding target data according to the algorithm preset in pretreatment unit 301 pretreated magnetic resonance imaging image.In the present embodiment, the algorithm preset can be write feature extraction and algorithm for pattern recognition voluntarily according to the research topic demand of researcher.And adopt the work station of multiple stage multi-core as node, thus the Parallel application based on MPI can well be met.Wherein, node should adopt the high-frequency as far as possible CPU of disposal ability, and provides internal memory high as far as possible, and to meet the demand of software data processing, the system of guarantee has the highest service efficiency.Processed the magnetic resonance imaging image sequence of acquisition in real time with the resource that SSH terminal submits to calculating script to call whole computing cluster by real-time processing host.
In embodiments of the present invention, magnetic resonance imaging main frame 202, before Real-time Obtaining magnetic resonance imaging image sequence starts, first can verify whether pretreatment unit 301 is connected with magnetic resonance imaging main frame 202, whether can efficient communication.After checking connection completes, also need to inquire about on magnetic resonance imaging main frame 202, thus find the scanned image sequence of current experiment in a large amount of scanned image sequence stored from data base.Concrete, this query script can adopt the Query enquiry module in DICOM development kit to realize, Query enquiry module then can pass through PID (patient number), PName (patient's name) inquires about, thus inquiry obtains all scanned image sequence of this patient (subjects), and list in program listing, then current experiment scanning sequence is selected, program will remember the numbering of Current Scan sequence, and whether detection current experiment has new sequence of pictures to generate in scanning automatically, have, newly-generated sequence of pictures is sent to pretreatment unit 301, after experiment terminates, then stop real-time image acquisition sequence.
In order to ensure the requirement of real-time of system, therefore, the running time of modules and the summation of data transmission period should be less than the TR of magnetic resonance scanner setting.
In embodiments of the present invention, magnetic resonance imaging image sequence is generated in real time by magnetic resonance imaging module 200, and timely magnetic resonance imaging image sequence is transferred on data processing module 300, carry out image procossing for data processing module 300, thus realize the gather and analysis of real-time magnetic resonance imaging data.Real-time magnetic resonance image-forming data acquisition analytical system framework performance provided by the invention is stablized, safe and reliable, easily extensible.In brain science research, real-time functional magnetic resonance imaging is compared with offline functionality nuclear magnetic resonance, and its feedback regulation mode is more accurate, real-time is better.To move at the end of a thread in experiment that detections, the research of brain-computer interface technology, brain function are machine-processed, brain perceive all has very important value in the adjustment of cognitive competence, the disease treatment relevant with cognition etc.
One of ordinary skill in the art will appreciate that: all or part of step realizing above-mentioned each embodiment of the method can have been come by the hardware that programmed instruction is relevant.Aforesaid program can be stored in a computer read/write memory medium.This program, when performing, performs the step comprising above-mentioned each embodiment of the method; And aforesaid storage medium comprises: ROM, RAM, magnetic disc or CD etc. various can be program code stored medium.
Last it is noted that above each embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to foregoing embodiments to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein some or all of technical characteristic; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.
Claims (9)
1. a real-time magnetic resonance image-forming data acquisition analytical method, is characterized in that, comprising:
Subjects is scanned, and generates magnetic resonance imaging image sequence in real time;
Described magnetic resonance imaging image sequence is processed in real time, to obtain the scan image data after process in real time.
2. real-time magnetic resonance image-forming data acquisition analytical method according to claim 1, is characterized in that, also comprise:
Scan image data after described process is showed subjects.
3. real-time magnetic resonance image-forming data acquisition analytical method according to claim 1 and 2, is characterized in that, describedly processes in real time described magnetic resonance imaging image sequence, comprises with the scan image data after obtaining process in real time:
Pretreatment is carried out to described magnetic resonance imaging image sequence, to obtain pretreated magnetic resonance imaging image;
Algorithm according to presetting extracts corresponding target data in described pretreated magnetic resonance imaging image.
4. real-time magnetic resonance image-forming data acquisition analytical method according to claim 3, is characterized in that, describedly carries out pretreated operation to described magnetic resonance imaging image sequence and comprises:
Format conversion is carried out to described magnetic resonance imaging image sequence;
Magnetic resonance imaging image sequence after format conversion is corrected, standardization and go interference process.
5. a real-time magnetic resonance image-forming data acquisition analytical system, is characterized in that, comprising:
Magnetic resonance imaging module, for scanning subjects, and generates magnetic resonance imaging image sequence in real time;
Data processing module, for processing in real time described magnetic resonance imaging image sequence, to obtain the scan image data after process in real time.
6. real-time magnetic resonance image-forming data acquisition analytical system according to claim 5, is characterized in that, also comprise display module, for the scan image data after described process is showed subjects.
7. the real-time magnetic resonance image-forming data acquisition analytical system according to claim 5 or 6, is characterized in that, described magnetic resonance imaging module comprises magnetic resonance scanner and magnetic resonance imaging main frame,
Described magnetic resonance scanner is used for scanning subjects, and generates magnetic resonance imaging image sequence;
Described magnetic resonance imaging main frame is used for magnetic resonance imaging image sequence described in Real-time Obtaining.
8. real-time magnetic resonance image-forming data acquisition analytical system according to claim 7, is characterized in that, described data processing module comprises pretreatment unit and coupling extraction unit,
Described pretreatment unit is used for carrying out pretreatment to described magnetic resonance imaging image sequence, to obtain pretreated magnetic resonance imaging image;
The algorithm that described coupling extraction unit is used for according to presetting extracts corresponding target data in described pretreated magnetic resonance imaging image.
9. real-time magnetic resonance image-forming data acquisition analytical system according to claim 8, is characterized in that, described pretreatment unit comprises format conversion subelement, syndrome unit, normalizer unit and goes to disturb subelement,
Described format conversion subelement is used for carrying out format conversion to described magnetic resonance imaging image sequence;
Described syndrome unit is used for carrying out feature correction to the magnetic resonance imaging image sequence after format conversion;
The standard form that described normalizer unit is used for according to presetting carries out standardization to the magnetic resonance imaging image sequence after format conversion;
The described interference subelement that goes is for going interference process to the magnetic resonance imaging image sequence after format conversion.
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