CN105463626A - Alginate medical film and preparation method thereof - Google Patents
Alginate medical film and preparation method thereof Download PDFInfo
- Publication number
- CN105463626A CN105463626A CN201510958209.3A CN201510958209A CN105463626A CN 105463626 A CN105463626 A CN 105463626A CN 201510958209 A CN201510958209 A CN 201510958209A CN 105463626 A CN105463626 A CN 105463626A
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- preparation
- alginate
- alginates
- medical films
- auxiliary element
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F9/00—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments
- D01F9/04—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments of alginates
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties
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- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Textile Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Materials For Medical Uses (AREA)
- Artificial Filaments (AREA)
Abstract
The invention discloses an alginate medical film and a preparation method thereof. Sodium alginate is used as a main raw material, and a special spinneret plate with only one long and narrow slit is adopted to form the alginate medical film through a wet spinning technology for preparing alginate fiber.
Description
Technical field
The present invention relates to field of medical materials, particularly relate to a kind of alginates medical films and preparation method thereof.
Background technology
Alginate dressing is the important component part of modern moist dressing, but up to the present, is all confined to first prepare alginate fibre, and then prepares alginate dressing.
Using the films such as alginates preparation medically have much potential application as biological wound-protecting film, apply ointment or plaster and paste skin layers, artificial skin, transparent dressing etc., except keeping the moisture absorption of the alginate dressing be prepared from alginate fibre, moisturizing, easily becoming gel and except discharging calcium ion, alleviating wound pain, promote the functions such as organization healing, membrane structure characteristic makes alginates medical films without fibre shedding, ultrathin type, transparent in facilitate outstanding advantages such as observing Wound healing situation, is good novel wound dressing.
But the technological difficulty that current alginates medical films is produced is very high, progress is slow, does not still have technique and the technology of large-scale production, also without any the alginates medical films of industrialization.The preparation method that Li Qianqian proposes in " preparation of alginate film, sign and electrochemical research thereof " paper is the mixed solution surface spraying calcium chloride solution by sodium alginate and polyethylene glycol, dries rear cleaning.With this preparation method except stoste needs to be coated on base material as on plate glass, steel plate or plastic sheeting, can only at the solidification liquid of side spraying above, one side carry out double diffusion solidify cause two sides structure asymmetric outside, primary film does not have stretchedly to make molecularly oriented and apply under tension state dry, to such an extent as to the alginates film prepared is hard, crisp, is difficult to practical, and produce and cannot carry out continuously, in addition, easily make foaming be mixed into during coating stoste, form defect.
Preparation method of the present invention is ejected in solidification liquid continuously owing to adopting the spinnerets of slit; film double-sided carries out symmetric double diffusion simultaneously and solidifies; and equally with fiber preparation process can carry out stretching, wash, drying, rolling etc.; prepared film is uniform and stable; the defect that bubble-free causes, can realize full-automation, large-scale production, and prepared alginates film fracture strength is high; pliability is good, can be used for commercial application.
Guangdong Taibao Medical Science Technology Co., Ltd. has Registering product to be the production and selling of " alginates medical films ", but in fact, this product is the alginate dressing that alginate fibre is prepared through needle punched non-woven fabrics technique, is essentially different with alginates medical films of the present invention.
The present invention has huge facilitation for the production of new type functional thin films of alginate and application.
Summary of the invention
The object of the present invention is to provide a kind of alginates medical films and preparation method thereof.
For achieving the above object, the invention provides a kind of preparation method of alginates medical films, it is characterized in that, with sodium alginate and auxiliary element for raw material, wherein sodium alginate is main raw material, adopt the wet spinning technology preparation preparing alginate fibre, wherein, adopt the spinnerets only having a long and narrow seam.
Further, described sodium alginate accounts for and is not less than 80 quality %; Auxiliary element is not more than 20 quality %;
Described auxiliary element is one or more in cm-chitosan, sodium carboxymethylcellulose, polyvinyl alcohol.
Further, take sodium alginate as main raw material, one or more of cm-chitosan, sodium carboxymethylcellulose, polyvinyl alcohol are auxiliary element, and water is solvent, and homogeneous dissolving, filtration, vacuum defoamation technique are prepared into spinning solution;
Again with the mixed solution of calcium chloride solution or calcium chloride and zinc chloride for solidification liquid, ejection stoste through solidifying, hot water drawing-off, washing, solvent extraction, drying, winding prepare; Described solvent is one or more in methyl alcohol, ethanol, acetone.
The alginates medical films that the present invention also protects described preparation method to prepare.
Further, being take alginate as the film of main component.
Further, thickness is 12um ~ 200um.
Preparation technology's wet spinning technology of described alginate fibre is known, namely be raw material with sodium alginate, the techniques such as homogeneous dissolving, filtration, vacuum defoamation are prepared into spinning solution, take solidification liquid as calcium chloride, ejection stoste through solidifying, hot water drawing-off, washing, solvent extraction, drying, the preparation of the technique such as winding.But being used for preparing thin films of alginate with the wet spinning technology preparing alginate fibre is that no one attempts and put into practice, also without any disclosed Literature.Especially, spinnerets wherein used is different from the used spinnerets (as shown in Figure 2) having the spinneret cap of many circular apertures (general aperture is 0.06mm ~ 0.5mm) to form by many groups of fibre spinning, but adopts the spinnerets (as shown in Figure 1) only having a long and narrow seam.The gap width be rectangle and length, according to thickness and the wide selection setting of film of prepared film.
Extractant adopts the one of methyl alcohol, ethanol or acetone etc., preferably, adopts acetone to adopt low boiling point solvent as much as possible, be beneficial to reduce baking temperature with the flexibility of enhanced film and completely removal dissolvent residual ensure that product has good biocompatibility.
Accompanying drawing explanation
Fig. 1 is film spinnerets schematic diagram;
Fig. 2 is fibre spinning nozzle assembly schematic diagram.
Detailed description of the invention
Be described below in detail embodiments of the invention, the example of described embodiment is shown in the drawings, and wherein same or similar label represents same or similar element or has element that is identical or similar functions from start to finish.Be exemplary below by the embodiment be described with reference to the drawings, be intended to for explaining the present invention, and can not limitation of the present invention be interpreted as.Unreceipted concrete technology or condition person in embodiment, according to the technology described by the document in this area or condition or carry out according to product description.Agents useful for same or the unreceipted production firm person of instrument, being can by the conventional products of commercial acquisition.
embodiment 1: the preparation of alginates medical films
Prepared by stoste: the sodium alginate of 4.5 quality % intrinsic viscosities is dissolved in 60
0in the warm water of C, stirring and dissolving, filters, deaeration, leaves standstill, obtains spinning solution;
Spinning: spinning solution is through the compressed air extrusion of 0.4MPa pressure, measured by measuring pump, then through candle filter, gooseneck, be immersed in the ejection thread of the spinnerets in the first coagulating basin solidification liquid and solidifying traction, the concentration 4.0 quality % of solidification liquid calcium chloride, temperature 40
0c, successively through 70
0c hot water drawing-off, 60
0c washing, extraction, dry, reel.Described spinnerets stitches wide 0.15mm.
It is the long and narrow seam spinnerets of list of 0.075mm that the present embodiment adopts seam wide.
Compliance test result: the medical thickness 12um of gained alginates.
embodiment 2: the preparation of alginates medical films
Prepared by stoste: the sodium alginate of 4.5 quality % intrinsic viscosities is dissolved in 40
0in the warm water of C, stirring and dissolving, filters, deaeration, leaves standstill, obtains spinning solution.
Spinning: spinning solution is through the compressed air extrusion of 0.4MPa pressure, measured by measuring pump, then through candle filter, gooseneck, be immersed in the ejection thread of the spinnerets in the first coagulating basin solidification liquid and solidifying traction, the concentration 5.0 quality % of solidification liquid calcium chloride and zinc chloride mixed solution, wherein the mol ratio of calcium chloride and zinc chloride is 1:1, temperature 60
0c, successively through 70
0c hot water drawing-off, 60
0c washing, extraction, dry, reel.Described spinnerets stitches wide 0.50mm.
It is the long and narrow seam spinnerets of list of 0.50mm that the present embodiment adopts seam wide.
Compliance test result: the medical thickness 200um of gained alginates.
Although illustrate and describe embodiments of the invention above, be understandable that, above-described embodiment is exemplary, can not be interpreted as limitation of the present invention, those of ordinary skill in the art can change above-described embodiment within the scope of the invention when not departing from principle of the present invention and aim, revising, replacing and modification.
Claims (6)
1. a preparation method for alginates medical films, is characterized in that, with sodium alginate and auxiliary element for raw material, wherein sodium alginate is main raw material, adopts the wet spinning technology preparation preparing alginate fibre, wherein, adopts the spinnerets only having a long and narrow seam.
2. the preparation method of alginates medical films described in claim 1, is characterized in that, described sodium alginate accounts for and is not less than 80 quality %; Auxiliary element is not more than 20 quality %;
Described auxiliary element is one or more in cm-chitosan, sodium carboxymethylcellulose, polyvinyl alcohol.
3. the preparation method of alginates medical films described in claim 1, it is characterized in that, take sodium alginate as main raw material, one or more of cm-chitosan, sodium carboxymethylcellulose, polyvinyl alcohol are auxiliary element, water is solvent, and homogeneous dissolving, filtration, vacuum defoamation technique are prepared into spinning solution;
Again with the mixed solution of calcium chloride solution or calcium chloride and zinc chloride for solidification liquid, ejection stoste through solidifying, hot water drawing-off, washing, solvent extraction, drying, winding prepare; Described solvent is one or more in methyl alcohol, ethanol, acetone.
4. the alginates medical films for preparing of preparation method described in any one of claim 1-3.
5. alginates medical films described in claim 4, is characterized in that, is take alginate as the film of main component.
6. alginates medical films described in claim 4, is characterized in that, thickness is 12um ~ 200um.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510958209.3A CN105463626A (en) | 2015-12-18 | 2015-12-18 | Alginate medical film and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510958209.3A CN105463626A (en) | 2015-12-18 | 2015-12-18 | Alginate medical film and preparation method thereof |
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| CN105463626A true CN105463626A (en) | 2016-04-06 |
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| CN201510958209.3A Pending CN105463626A (en) | 2015-12-18 | 2015-12-18 | Alginate medical film and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281539A (en) * | 2017-06-05 | 2017-10-24 | 江西省科学院应用化学研究所 | A kind of preparation method of soluble paper-like alginates compound hemostatic film |
| CN109943899A (en) * | 2019-03-27 | 2019-06-28 | 西宝生物科技（上海）股份有限公司 | A kind of Biodegradable anti-biotic material and preparation method thereof |
| CN109972233A (en) * | 2019-02-19 | 2019-07-05 | 青岛大学 | The preparation method of the biodegradable alginic acid fibre with high-intensity and high-tenacity |
| CN115094539A (en) * | 2022-07-13 | 2022-09-23 | 大连工业大学 | Heat-insulating flame-retardant sodium alginate/polyvinyl alcohol aerogel fiber and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101519812A (en) * | 2008-02-25 | 2009-09-02 | 李换位 | Process for manufacturing oxidized cellulose regenerated fibrils or thin films |
| CN103060946A (en) * | 2012-12-21 | 2013-04-24 | 稳健实业(深圳)有限公司 | Blend fibers of alginate and sodium carboxymethyl cellulose and preparation method and application thereof |
| CN103132179A (en) * | 2013-03-27 | 2013-06-05 | 海安县锦荣化纤有限公司 | Method for preparing alginate fiber |
| CN104436281A (en) * | 2014-12-06 | 2015-03-25 | 江西省科学院应用化学研究所 | Preparation method of porous sodium alginate nano-fiber wound dressing |
-
2015
- 2015-12-18 CN CN201510958209.3A patent/CN105463626A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101519812A (en) * | 2008-02-25 | 2009-09-02 | 李换位 | Process for manufacturing oxidized cellulose regenerated fibrils or thin films |
| CN103060946A (en) * | 2012-12-21 | 2013-04-24 | 稳健实业(深圳)有限公司 | Blend fibers of alginate and sodium carboxymethyl cellulose and preparation method and application thereof |
| CN103132179A (en) * | 2013-03-27 | 2013-06-05 | 海安县锦荣化纤有限公司 | Method for preparing alginate fiber |
| CN104436281A (en) * | 2014-12-06 | 2015-03-25 | 江西省科学院应用化学研究所 | Preparation method of porous sodium alginate nano-fiber wound dressing |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281539A (en) * | 2017-06-05 | 2017-10-24 | 江西省科学院应用化学研究所 | A kind of preparation method of soluble paper-like alginates compound hemostatic film |
| CN109972233A (en) * | 2019-02-19 | 2019-07-05 | 青岛大学 | The preparation method of the biodegradable alginic acid fibre with high-intensity and high-tenacity |
| CN109943899A (en) * | 2019-03-27 | 2019-06-28 | 西宝生物科技（上海）股份有限公司 | A kind of Biodegradable anti-biotic material and preparation method thereof |
| CN115094539A (en) * | 2022-07-13 | 2022-09-23 | 大连工业大学 | Heat-insulating flame-retardant sodium alginate/polyvinyl alcohol aerogel fiber and preparation method thereof |
| CN115094539B (en) * | 2022-07-13 | 2023-08-22 | 大连工业大学 | Heat-insulating flame-retardant sodium alginate/polyvinyl alcohol aerogel fiber and preparation method thereof |
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Application publication date: 20160406 |