CN105456287B - Selenium disulfide ultrafine powder and preparation method thereof - Google Patents
Selenium disulfide ultrafine powder and preparation method thereof Download PDFInfo
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- CN105456287B CN105456287B CN201510880617.1A CN201510880617A CN105456287B CN 105456287 B CN105456287 B CN 105456287B CN 201510880617 A CN201510880617 A CN 201510880617A CN 105456287 B CN105456287 B CN 105456287B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
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Abstract
The invention discloses selenium disulfide ultrafine powder and preparation method thereof, belong to articles for washing field.The present invention solves medium ball milling micronizing and prepares selenium disulfide ultrafine powder to there is the production time as lotion long, and selenium disulfide particle is big, disperses uneven, instable quality problems.The particle diameter of selenium disulfide ultrafine powder is (1~50) μm in the present invention.The method of the present invention is as follows：First, selenium disulfide dry powder, purified water, pharmaceutical grade titanium dioxide and pharmaceutical grade glycerine are well mixed, are subsequently adding citron acid for adjusting pH value between 3.5~4.5；2nd, crushing of being milled in grinding type micronizer is subsequently placed in, that is, has obtained selenium disulfide ultrafine powder.Selenium disulfide ultrafine powder of the present invention can be applied to the daily chemical products such as lotion, shampoo, hair conditioner.
Description
Technical field
The invention belongs to articles for washing field；Specifically related to selenium disulfide ultrafine powder and preparation method thereof.
Background technology
Selenium disulfide is bright orange to red-brown powder；It is water insoluble with faint hydrogen sulfide odor, chloroform is slightly soluble in,
It is atomic to be dissolved in ether, it is substantially insoluble in other organic solvents.Under daylight, high temperature or alkalescence condition, easy Oxidative inactivation blackening；
The necessary lucifuge of product, is stored in shady and cool, closed container.
Selenium disulfide is used for dandruff dispelling, seborrhea, dandruff dermatitis, tinea versicolor etc..It is usually used in external application, with 1%
Or 2.5% put scalp on the skin outside lotion, weekly 1~2 time to every 4 weeks 1 time as needed.
Micronization technology is a kind of new skill that 20 century 70s derive to adapt to the development of modern high technology later
Art, generally uses medium ball grinding method, and the drug particle for obtaining is at 50~200 μm；Nowadays, two in production selenium disulfide lotion
The micronizing of selenium sulfide medicinal powder uses this technology.Its shortcoming：First, it is necessary to place medium micronizing, the production cycle is long, work
Skill is complicated, and powder body (selenium disulfide medicinal powder) particle is big, uneven, so as to influence dispersion of the selenium disulfide in lotion base not
Uniformity, medicinal powder particle suspension unstability, the unstability of final influence product quality；Second, a production time (ball long
The mill cycle needs 5-6 hours), loss is big, low production efficiency.
The content of the invention
The present invention solves medium ball milling micronizing and prepares selenium disulfide ultrafine powder has selenium disulfide as lotion
Grain is big, disperses uneven, instable quality problems, while shortening the production time, and provides selenium disulfide Ultramicro-powder
Body and preparation method thereof.
The particle diameter of selenium disulfide ultrafine powder is (1~50) μm in the present invention.
The preparation method of selenium disulfide ultrafine powder is carried out in the steps below in the present invention：
It is step one, selenium disulfide dry powder, purified water, pharmaceutical grade titanium dioxide (i.e. medical grade titanium dioxide) and pharmaceutical grade is sweet
Oil is well mixed, is subsequently adding citron acid for adjusting pH value between 3.5~4.5；
Step 2, crushing of being milled in grinding type micronizer is subsequently placed in, that is, has obtained selenium disulfide ultrafine powder.
Selenium disulfide dry powder, purified water, pharmaceutical grade titanium dioxide (i.e. medical grade titanium dioxide) and pharmaceutical grade are sweet in step one
The mass ratio of oil is 1:1:2:3.
In step 2 crushing of milling is carried out in power 1.5kW, speed of mainshaft 1500r/min.
Grinding time of being milled in step 2 is 30min~60min.
The ultrafine powder granular size of selenium disulfide of the present invention is controlled in 1~50 μ m.Received as fruit granule is entirely reached
Meter level, then the aspect such as the toxicology of selenium disulfide medicinal powder, biology and pharmacodynamics needs safety evaluation again.In other words,
Nanoscale selenium disulfide medicinal powder, its lotion product needs to be carried out research and declared by new drug registration again, increases cost.The present invention is produced
The granular size of product in the middle of medium ball abrasive particle and nano-scale particle, i.e., less than 100 times or so of medium ball milling micro powder granule,
More than between nano-scale particle 1000；Both selenium disulfide disperseed homogeneity and hanged because ball milling micro powder granule is big in having solved lotion
Instable quality problems are floated, meanwhile, it also avoid because after selenium disulfide nano powder, its preparation lotion is noted by new drug again
The risk that volume is evaluated.
Selenium disulfide medicinal powder is changed by surface nature after micronization processes, and specific surface area is greatly increased, according to
Noyes-Whitney equations, reduce due to particle diameter, specific surface area increases, so as to increased selenium disulfide medicinal powder in lotion
Homogeneity and stability；Further, since the reduction of selenium disulfide medicinal powder particle diameter can also increase the adhesion of medicinal powder and skin and mucosa,
So as to increase the contact area of medicine and skin, extend contact time, the sufficiently effective performance pharmacological effect of medicine can be made,
Connect the drug effect that improve selenium disulfide lotion.
1~50 μm of the particle of the inventive method selenium disulfide medicinal powder, selenium disulfide prepared by traditional ball grinding technique micronizing
50~200 μm of particle diameters using the preparation of ultra micro powdering techniques of particle of medicinal powder are small, with multiple advantage：
(1) its special chemical property due to selenium disulfide, preparation process adds a small amount of stabilizer, using wet milling
Method, reaches ultra micro efflorescence purpose；Its ultra micro powdering techniques is different from liposome, solid dispersions etc. and is free of host material, only
It is made up of medicine, and contains appropriate stabilizer, it is ensured that main drug effectiveness, it also avoid the use of carrier, reduces cost subtracts
The incidence of toxic and side effect is lacked.
(2) particle diameter is small, increases the adhesion of medicine and skin, and extension medicine is improved in the holdup time of pathogen skin
The bioavilability of medicine.
(3) medicine stability is improved；Particle diameter is reduced, and specific surface area increase, surface can also increase, and surface charge is big,
The particle band mutually exclusive power of identical charges increases, and reduces particle buildup, increases stability.
Invention applies micronizer tool, the ultra micro efflorescence without medium is carried out to selenium disulfide medicinal powder and has been crushed,
It is made selenium disulfide particle and reaches 1~50 μm of ultrafine powder, selenium disulfide lotion, shampoo and hair conditioner can be directly appended to
Matrix in, reach simplified production technology, shorten the production time and improve the requirement of product internal control quality standard.
By the Grain size controlling of selenium disulfide at 1~50 μm, this not only simplifies and shortens selenium disulfide lotion to the present invention
Production technology, it is often more important that substantially increase dispersion homogeneity of the selenium disulfide in lotion base and the stability for suspending,
Directly enhance the product quality of selenium disulfide lotion.
Compared with the technique of selenium disulfide prepared by the micronizing of traditional ball grinding technique, particle reduces 100 times or so, is washing
Dispersion homogeneity in agent matrix, stability are more preferable than ball milling powder body；Technique is simplified, the production time is shortened, improve
Production efficiency, also reduces production cost, is easily applied to industrialization.
The route of the inventive method is simple, and process conditions are gentle, morphology microstructure, steady quality：Micronizer sets not
Same technological parameter, you can obtain the homogeneous powder of different particulates, production technology collimation is good, and products therefrom homogeneity is good, quality
Stabilization.
Outstanding advantage of the present invention be using single or multiple equipment combine, carry out continuous prodution, can easily with
Seamless connection is realized in the technological process that pharmaceutical industries metaplasia is produced, and the technical characterstic is that other conventional arts are unrivaled.
Selenium disulfide ultrafine powder of the present invention can be applied to the daily chemical products such as lotion, shampoo, hair conditioner.
Brief description of the drawings
Fig. 1 is the grain size distribution that powder after 30min is ground in specific embodiment six.
Specific embodiment
Specific embodiment one：The particle diameter of selenium disulfide ultrafine powder is 1 μm in present embodiment.
Specific embodiment two：The particle diameter of selenium disulfide ultrafine powder is 30 μm in present embodiment.
Specific embodiment three：The particle diameter of selenium disulfide ultrafine powder is 50 μm in present embodiment.
Specific embodiment four：The particle diameter of selenium disulfide ultrafine powder is 5 μm in present embodiment.
Specific embodiment five：The particle diameter of selenium disulfide ultrafine powder is 20 μm in present embodiment.
Specific embodiment six：The particle diameter of selenium disulfide ultrafine powder is 10 μm in present embodiment, and its preparation method is
Carry out in the steps below：
Step one, selenium disulfide dry powder, purified water, pharmaceutical grade titanium dioxide and pharmaceutical grade glycerine are well mixed, Ran Houjia
Enter citron acid for adjusting pH value between 3.5~4.5；
Step 2, it is subsequently placed in grinding type micronizer, is ground in power 1.5kW, speed of mainshaft 1500r/min
Be milled broken 30min (see Fig. 1), sieving, that is, obtained selenium disulfide ultrafine powder；It is selenium disulfide dry powder wherein in step one, pure
The mass ratio for changing water, pharmaceutical grade titanium dioxide and pharmaceutical grade glycerine is 1:1:2:3.
Present embodiment is made the dispersion homogeneity of selenium disulfide ultrafine powder, the theoretical foundation of stability：By 6 months
Product quality acceleration investigates experiment, and the quality of product is stability, meets target level of product quality.
Claims (1)
1. a kind of preparation method of selenium disulfide ultrafine powder, it is characterised in that carry out in the steps below：
Step one, selenium disulfide dry powder, purified water, pharmaceutical grade titanium dioxide and pharmaceutical grade glycerine are well mixed, are subsequently adding Chinese holly
Rafter acid for adjusting pH value between 3.5~4.5, wherein selenium disulfide dry powder, purified water, pharmaceutical grade titanium dioxide and pharmaceutical grade glycerine
Mass ratio is 1:1:2:3；
Step 2, it is subsequently placed in grinding type micronizer to enter under conditions of power 1.5kW, speed of mainshaft 1500r/min
Row is milled and crushes 30min~60min, that is, obtained the selenium disulfide composite superfine powder body that particle diameter is 1~50 μm.
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| CN201510880617.1A CN105456287B (en) | 2015-12-03 | 2015-12-03 | Selenium disulfide ultrafine powder and preparation method thereof |
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| CN201510880617.1A CN105456287B (en) | 2015-12-03 | 2015-12-03 | Selenium disulfide ultrafine powder and preparation method thereof |
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| CN105456287A CN105456287A (en) | 2016-04-06 |
| CN105456287B true CN105456287B (en) | 2017-06-30 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4205726A4 (en) * | 2021-10-08 | 2024-02-14 | Zhang, Zhiang | Product for treating skin fungi and micronized preparation method therefor |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9463201B2 (en) | 2014-10-19 | 2016-10-11 | M.G. Therapeutics Ltd | Compositions and methods for the treatment of meibomian gland dysfunction |
| MX2018012390A (en) | 2016-04-14 | 2019-07-04 | Azura Ophthalmics Ltd | Selenium disulfide compositions for use in treating meibomian gland dysfunction. |
| CA3166357A1 (en) | 2020-01-10 | 2021-07-15 | Azura Ophthalmics Ltd. | Instructions for composition and sensitivity |
| CN113620258B (en) * | 2021-07-14 | 2022-11-01 | 江苏晨牌邦德药业有限公司 | Shampoo dandruff-removing itching-relieving washing and protecting reagent additive |
| CN114788788B (en) * | 2022-05-09 | 2023-08-01 | 无锡知妍生物科技有限公司 | Selenium sulfide wrapping technology and selenium sulfide shampoo |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101951869A (en) * | 2007-09-15 | 2011-01-19 | 特许品牌有限公司 | Shampoo |
| CN102060277A (en) * | 2010-11-25 | 2011-05-18 | 广东先导稀有材料股份有限公司 | Production method of selenium sulfide |
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- 2015-12-03 CN CN201510880617.1A patent/CN105456287B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101951869A (en) * | 2007-09-15 | 2011-01-19 | 特许品牌有限公司 | Shampoo |
| CN102060277A (en) * | 2010-11-25 | 2011-05-18 | 广东先导稀有材料股份有限公司 | Production method of selenium sulfide |
Non-Patent Citations (2)
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| 原子荧光光谱法测定二硫化硒洗剂中硒的含量;刘彦刚等;《中国药事》;20121020;第26卷(第10期);第1105页左栏第1-4行 * |
| 超微粉碎技术的应用现状与发展趋势;谢瑞红等;《中国粉体技术》;20090615;第15卷(第3期);第64页右栏第1-3行，第65页左栏"1.3 超微粉碎的优点"项下 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4205726A4 (en) * | 2021-10-08 | 2024-02-14 | Zhang, Zhiang | Product for treating skin fungi and micronized preparation method therefor |
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