CN105439928A - Prodrug of vitamin A acid and quasi-vitamin A acid compounds - Google Patents

Prodrug of vitamin A acid and quasi-vitamin A acid compounds Download PDF

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CN105439928A
CN105439928A CN201510594392.3A CN201510594392A CN105439928A CN 105439928 A CN105439928 A CN 105439928A CN 201510594392 A CN201510594392 A CN 201510594392A CN 105439928 A CN105439928 A CN 105439928A
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carbon atom
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thiazolinyl
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CN105439928B (en
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于崇曦
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Taifeier biomedical (Suzhou) Co.,Ltd.
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于崇曦
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Abstract

The present invention relates to design and synthesis of a prodrug of vitamin A acid and quasi-vitamin A acid compounds, wherein the prodrug has a positive charge and a formula 31 structure as shown in the general formula (31). The compound can be obtained by a reaction of the vitamin A acid and related compounds thereof with appropriate alcohol, mercaptan or amine by using a coupling agent. Experimental results show that over 90% of prodrugs can return to parent drugs within several minutes. In therapy, the prodrugs can perform transdermal administration for any therapy, and most side effects of the vitamin A acid and the -quasi-vitamin A acid compounds are avoided. A controlled release transdermal administration system of a prodrug can keep the concentration of the vitamin A acid and the quasi-vitamin A acid compounds in the blood stable in the optimum therapeutic concentration, so that the therapeutic effect is improved and the side effects of the vitamin A acid and quasi-vitamin A acid compounds are reduced. The transdermal administration of these prodrugs has another great benefit of being more convenient in administration, especially for pediatric administration.

Description

The prodrug of V-A acidic and retinoid acid compound
The application is the divisional application of No. 200780049882.9 Chinese invention patent application.The applying date of original application is on 01 15th, 2007, and denomination of invention is " having the positively charged water miscible V-A acidic of rapid skin penetration speed and the prodrug of retinoid acid compound ".
Technical field
The present invention relates to positive charge and the prodrug of water miscible V-A acidic and retinoid acid compound and the application on any V-A acidic and elliptic function-like solution compounds-treatable conditions for the treatment of human or animal thereof.Especially, the present invention makes V-A acidic and retinoid acid compound energy fast skin penetration.
Background technology
Retinoic acid is a compounds, and its structure contains four the isoprenoid structural units combined in mode from beginning to end.V-A acidic comprises all-trans vitamin A acid (retinoic acid), cis-isomery retinoic acid, as isotretinon (accutane), 9-cis vitamin A acid (A Li retinoic acid), Vitamin A (vitamin A), 4-[1-(5,6,7,8-tetrahydrochysene-3,5,5,8,8-pentamethyl--2-naphthyl) vinyl] phenylformic acid (Bexarotene, Targretin ), retinene, thunder is for taking sieve (retiferol), (E, E, E)-7-(2-n-propoxy--5, 5, 8, 8-tetramethyl--5, 6, 7, 8-tetrahydrochysene-naphthalene-3-base) the fluoro-3-methyl-2 of-6-, 4, the acid of 6-sarohornene, adapalene (6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid), acyclic retiniod [(2E, 4E, 6E, 10E)-3, 7, 11, 15-tetramethyl--2, 4, 6, 10, 14-16 carbon 5 alkene acid (hexadecapentaenoicacid)], ethyl (E, E, E)-7-(2-n-propoxy--5, 5, 8, 8-tetramethyl--5, 6, 7, 8-tetrahydrochysene-naphthalene-3-base) the fluoro-3-methyl-2 of-6-, 4, 6-sarohornene acid esters, and the derivative of their natural and synthesis.Multiple retinoid acid compound (U.S. Patent number: 5,648,563 that patent reports multiple synthesise vitamins A acids and there is retinoic acid activity; 5,648,385; 5,618,839; 5,559,248; 5,616,712; 5,616,597; 5,602,135; 5,599,819; 5,556,996; 5,534,516; 5,516,904; 5,498,755; 5,470,999; 5,468,879; 5,455,265; 5,451,605; 5,426,118; 5,407,937; 5,399,586; 5,399,561; 5,391,753).V-A acidic plays very important effect to many life process, comprises vision, reproduction, metabolism, differentiation, skeleton development and the pattern formation (patternformation) in fetal development period.Vitamin A (vitamin A) and retinene are in the state of chemical equilibrium in vivo, and it is active to have equivalent anti-xeropthalmus.Vitamin A and opsin, i.e. intraretinal rod pigment, in conjunction with formation rhodopsin, rhodopsin is extremely important to visual adaptation dark.Lack that Vitamin A can cause yctalopia, keratomalacia, keratinization and xerosis cutis, anti-infection ability reductions, decreased growth, sclerotin thicken, reflunomide generates minimizing, with fetal anomaly (PDRGenerics, 1996, secondedition, MedicalEconomics, Montvale, NewJersey, pg3094).Topical tretinoin (all-trans vitamin A acid) can reduce the cohesiveness of follicular epithelial cells, reduces trickle acne and is formed and stimulate Mitosis, increases the renewal of follicular epithelial cells and causes the discharge of acne.Retinoic acid topical can treat acne vulgaris, photoageing, pigment macula (chloasma hepaticum) and premature wrinkles, the healing of drug-induced photosensitization, psoriasis, epidermal wound, xerophthalmia, keloid, epiderm skin seborrheic keratosis (PDRGenerics, 1996, secondedition, MedicalEconomics, Montvale, NewJersey, pg2981).Accutane can suppress sebiferous gland function and keratinization.Accutane is applicable to treat serious recalcitrant cystic acne, rodent cancer, cervical cancer, mycosis fungoides (T-cell lymphoma,cutaneous), darier disease, lamellar ichthyosis, pityriasis rubra pilaris, the infection of herpes simplex, Grover disease, lichen planus, the acne erythematosa of stubbornness, palmoplantar keratoderma, leukoplasia, the thin bag cancer of basosquamous and xeroderma pitmentosum.A Li retinoic acid (9-cis-retinoic acid) is a natural endogenous retinoic acid, its can in conjunction with and activate all known intracellular Vitamin A receptor subtypes (RAR, RAR, RAR, RXR, RXR, and RXR).These acceptors are once namely activation can be used as transcription factor, and in normal cell and cancer cells, regulation and control can control the expression of the gene of cytodifferentiation and propagation.A Li retinoic acid can suppress the growth of Kaposi's sarcoma (KS) cell in testing in vitro.A Li retinoic acid is used for the treatment of Kaposi's sarcoma (KS) and myelodysplastic syndrome.Thunder can be used for treatment perproliferative skin diseases as psoriasis, basaloma, keratinization and keratinization disorders, neoplastic conditions for expense sieve (retiferol) derivative, sebaceous gland disorders is as acne and seborrheic dermatitis, the state relevant to light injury, the skin injury that Exposure to Sunlight causes, wrinkle, elastosis and early ageing (Hilpert, etal., U.S.Pat.No.6437142).Adapalene can external curing acne vulgaris.Acyclic retiniod can be used for the prevention time property sent out cancer (YasutoshiMuto, etal., theNewEnglandJournalofMedicine, 340,1046 (1999)).(E, E, E)-7-(2-n-propoxy--5,5,8,8-tetramethyl--5,6,7,8-tetrahydrochysene-naphthalene alkene-3-base) the fluoro-3-methyl-2 of-6-, 4, the acid of 6-sarohornene may be used for treatment II-patients with type Ⅰ DM and other metabolic trouble (DengT, etal., Biol.Pharm.Bull.28 (7), 1192,2005).Targretin ) oral preparations can be used for treatment T-cell lymphoma,cutaneous (CTCL), head and neck cancer, general Kaposi's sarcoma, lung cancer, ovarian cancer, prostate cancer and renal cell carcinoma.Targretin topical administration may be used for treatment T-cell lymphoma,cutaneous (CTCL).
Another kind of optional administering mode is exactly topical administration.Topical drug delivery has several large advantage.This method helps to avoid medicine at the first pass metabolism of liver and gastro-intestinal tract.It can when exposing without the need to system by the medicine localized delivery of proper concn to object action site.Fishman (Fishman; Robert, U.S. Patent number 7,052,715) point out that another problem produced with oral medication is that, in order to effectively treat pain or the inflammation of remote location, the drug level in blood circulation must reach very high.These concentration often can directly needed for the reality of targeting in pain or injury far above hypothesis medicine.Yeager attempts by penetration enhancer administration PGE 1be used for the treatment of male erectile dysfunction (Yeager, JamesL. U.S. Patent number 6,693,135).SusanMilosovich etc. have designed and synthesized 4-dimethylaminobutyricacid acid testosterone ester hydrochloride (TSBH), and it has a fat-soluble part and one at physiological ph with the tertiary amine group that protonated form exists.They find that this prodrug (TSBH) is nearly 60 times [SusanMilosovich, etal., J.Pharm.Sci., 82,227 (1993)] of female medicine (TS) through the speed of human body skin.
Technical problem
V-A acidic and retinoid acid compound have been used to treat multiple state of health and have comprised acne, photoageing, psoriasis, ichthyosis, alopecia and various cancer.
But V-A acidic and retinoid acid compound fat-soluble too strong, does not dissolve completely in water.Microbial film has bilayer structure, and hydrophilic head construction is towards the aqueous regions of both sides.V-A acidic can enter biomembranous lipid layer, but because of similar compatibility reason their can stop wherein as a biomembranous part, effectively can not enter inner tenuigenin.Because V-A acidic has height unsaturation, V-A acidic is all very responsive to ultraviolet, air and oxygenant.After V-A acidic topical administration, can microbial film be entered but can not cell interior be entered into.Sunlight, air or oxygenant can make V-A acidic generation chemical reaction, cause skin rubefaction, burning sensation, cast off a skin, ftracture, bubble, or itch.When they are by oral administration, again can because of first pass effect, namely liver and gi tract are to the chemical degradation of compound, destroy and inactivation in several minutes.Oral vitamin A acids can cause unnecessary whole body system expose and cause many side effects.
Solution
The present invention relates to the Design and synthesis with the novel V-A acidic of positive charge and the prodrug of retinoid acid compound, and medicinal use.9-cis vitamin A acid (A Li retinoic acid), isotretinon (accutane), all-trans vitamin A acid (retinoic acid), Vitamin A (vitamin A), thunder are for taking sieve (retiferol), adapalene, acyclic retiniod, and the prodrug of retinoid acid compound has the structure of general formula (1 to 27) " structural formula 1 to 27 ":
In structural formula 1-27, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2Can by O, S, CH=CH, C ≡ C, CR 6R 6', aryl or heteroaryl or other ring system groups substitute; R 1And R 2Independent Shi Ke represents identical or different group separately, can be H, alkyl, alkoxyl, thiazolinyl or the alkynyl of arbitrary 1-12 carbon atom, aryl, or heteroaryl, or combines common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2Can by O, S, CH=CH, C ≡ C, CR 6R 6', aryl or heteroaryl or other ring system groups replace; R 3Represent H, alkyl, alkoxyl, thiazolinyl or the alkynyl of arbitrary 1-12 carbon atom, aryl or heteroaryl, wherein, any CH 2Can by O, S, CH=CH, C ≡ C, CR 6R 6', aryl or heteroaryl or other ring system groups replace; X represents O, S or NH; X 1Represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2R 5, COR 5,COOR 5, NR 4COR 5, SOR 5, SR 5, PO 3R 6R 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl of 1-6 carbon atom; X 2Represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2R 5, COR 5, COOR 5, NR 4COR 5, SOR 5, SR 5, PO 3R 6R 6', SOR 5, SR 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl of 1-6 carbon atom; X 3Represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2R 5, COR 5, COOR 5,NR 4COR 5, SOR 5, SR 5, PO 3R 6R 6', SOR 5, SR 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, the alkoxyl of 1-6 carbon atom; X 4Represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2R 5, COR 5, COOR 5, NR 4COR 5, SOR 5, SR 5, PO 3R 6R 6', SOR 5, SR 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl of 1-6 carbon atom; X 5Represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2R 5, COR 5,COOR 5, NR 4COR 5, SOR 5, SR 5, PO 3R 6R 6', SOR 5, SR 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl of 1-6 carbon atom; X 6Represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2R 5, COR 5, COOR 5, NR 4COR 5, SOR 5, SR 5, PO 3R 6R 6', SOR 5, SR 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl of 1-6 carbon atom; R 4Represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2R 5,COR 5, COOR 5, NR 6COR 5, SOR 5, SR 5, PO 3R 6R 6', SOR 5, SR 5, a 1-6 carbon atom alkyl, the alkoxyl of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5Represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2R 6, COR 6, COOR 6, NR 6COR 4, SOR 6, SR 6, PO 3R 6R 6', SOR 6, SR 6, a 1-6 carbon atom alkyl, the alkoxyl of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 11Represent H, OH, Cl, Br, F, I, NO 2, CN,SO 2R 5, COR 5, COOR 5, NR 6COR 5, SOR 5, SR 5, PO 3R 6R 6', SOR 5, SR 5, a 1-6 carbon atom alkyl, the alkoxyl of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 12Represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2R 5, COR 5, COOR 5, NR 6COR 5, SOR 5, SR 5, PO 3R 6R 6', SOR 5, SR 5, a 1-6 carbon atom alkyl, the alkoxyl of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6And R 6' separately independent Shi Ke represent identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2R 5, COR 5, COOR 5, NR 7COR 5, SOR 5, SR 5, PO 3R 7R 7', SOR 5, SR 5, the alkyl of a 1-6 carbon atom, the alkoxyl of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2Can by O, S, CH=CH, C ≡ C, CR 7R 7' aryl or heteroaryl, or other ring system groups substitute; R 7And R 7Independent Shi Ke represents identical or different group separately, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2R 5, COR 5, COOR 5,NR 6COR 5, SOR 5, SR 5, PO 3R 6R 6', SOR 5, SR 5, the alkyl of a 1-6 carbon atom, the alkoxyl of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2Can by O, S, CH=CH, C ≡ C, CR 6R 6', aryl or heteroaryl, or other ring system groups substitute; R 8And R 8' separately independent Shi Ke represent identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2R 5, COR 5, COOR 5, NR 4COR 5, SOR 5, SR 5, PO 3R 6R 6', SOR 5, SR 5, the alkyl of a 1-6 carbon atom, the alkoxyl of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2Can by O, S, CH=CH, C ≡ C, CR 6R 6', aryl or heteroaryl or other ring system groups substitute; R 9And R 9' separately independent Shi Ke represent identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2R 5, COR 5, COOR 5, NR 4COR 5, SOR 5, SR 5, PO 3R 6R 6', SOR 5, SR 5, the alkyl of a 1-6 carbon atom, the alkoxyl of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2Can by O, S, CH=CH, C ≡ C,CR 6R 6', aryl or heteroaryl, or other ring system groups substitute; R 10And R 10' separately independent Shi Ke represent identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2R 5, COR 5, COOR 5, NR 4COR 5, SOR 5, SR 5, PO 3R 6R 6', SOR 5, SR 5, the alkyl of a 1-6 carbon atom, the alkoxyl of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2Can by O, S, CH=CH, C ≡ C, CR 6R 6' aryl or heteroaryl, or other ring system groups substitute; T represents CH 2=C, CH=CH, C (CH 3)=CH, C ≡ C, C=O, C=S, CONH, CSNH, COO, OCO, COS, COCH 2Or CH 2CO; A -Represent Cl -, Br -, F -, I -, AcO -, citrate, or any anion; Two keys on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, C, H, O can be comprised, S, N and other atoms, and singly-bound, two key, triple bond and ring system can be contained.
Medicine no matter is through gastrointestinal tract or other approach absorb, and all needs with the form of molecule through barrier membranes.First medicine need dissolve, and if medicine has desirable biopharmaceutical properties, its can region from the regional diffusion of high density to lower concentration, strides across cytolemma and enters blood or systemic circulation system.All microbial films contain lipid as major ingredient.In biofilm structure, active molecule all has the head construction containing phosphatic high polarity, and, in most of the cases, the hydrocarbon tails of two very hydrophobic.Microbial film has bilayer structure, and hydrophilic head construction is towards the aqueous regions of both sides.Very hydrophilic medicine by very hydrophobic medicine stops wherein as a biomembranous part because of the reason of similar compatibility through biomembranous lipid layer, thus cannot effectively can not enter inner tenuigenin.
The object of the invention is, by improving solubleness in skin surface moisture of V-A acidic and related compound thereof and improving its penetrating velocity to microbial film and skin barrier, to make it by transdermal administration (external application).The prodrug of these novel V-A acidics and related compound thereof has two identical constructional features: they have a lipophilic part and one under physiological ph conditions with one-level, secondary or tertiary amine group (water-soluble portion) that protonated form exists.Such hydrophilic-lipophilic balance is that medicine effectively can pass microbial film necessary [SusanMilosovich, etal., J.Pharm.Sci., 82,227 (1993)].Amino with positive charge considerably increases the solubleness of medicine in water.In a lot of situation, the dissolving of medicine is step that is the slowest in absorption process or maximum speed limit.V-A acidic and the solubleness of related compound in skin surface moisture very low, can not with molecular form effectively through skin barrier.After they enter the microbial film of skin, because the reason of similar compatibility can stop wherein as a biomembranous part, thus effectively can not enter tenuigenin, i.e. the concentrated aqueous solution of a kind of semi liquid state of cell interior or suspension.When these novel prodrugs are with formulation transdermal administrations such as such as solution, spray, emulsion, ointment, latex or gels, they can be dissolved in rapidly in the moisture of skin surface.Positive charge in these prodrugs on amino can be combined with the negative charge of the phosphate end group of cytolemma.Therefore, the partial concn of medicine outside microbial film is very high thus contribute to these prodrugs by the region of area with high mercury to lower concentration.After these prodrugs enter into microbial film, hydrophilic parts can promote prodrug and enter tenuigenin.Because the residence time of these prodrugs outside the microbial film of skin surface is very short, thus can not causes skin burns, pain, itch or swelling, and skin also can not be responsive to sunlight.The penetrating velocity of these prodrugs in human body skin is measured by the Franz pond of improving in vitro, and wherein human body skin is separated human skin tissue (360-400 micron thickness) before huckle position or below.Accept solution formed by the physiological saline that 2 milliliters contain the bovine serum globulin of 2% and stirred with the speed of 600 revs/min.The relation of accumulation total amount to the time that these prodrugs and their female medicine pass skin measures by specific high performance liquid chromatography.Donor solution is by the solution containing 5% some V-A acidic prodrug, or 5% retinoic acid compounds suspension composition, all be dissolved in the mixed solution of phosphate buffer soln (0.2M) (v/v, 70/30) of 0.2 milliliter of ethanol and pH7.4, result as shown in Figure 1.Calculate the apparent penetrating value penetrating human body skin, obtain N, N-diethyllaminoethyl 9-cis-retinoate. HBr, N, N-diethyllaminoethyl retinoids ester hydrobromate, N, N-diethyllaminoethyl all-trans vitamin A acid ester hydrobromate, retinyl-N, N-dimethyl-2-glycine ester hydrochloride, N, N-diethyllaminoethyl 4-[1-(5, 6, 7, 8-tetrahydrochysene-3, 5, 5, 8, 8-pentamethyl--2-naphthyl) vinyl] benzoic ether hydrochloride, 9-cis-retinoic acid (A Li retinoic acid), isotretinon (accutane), all-trans vitamin A acid (retinoic acid), Vitamin A (vitamin A) and Bexarotene the apparent penetrating value penetrating human body skin be respectively 0.72 milligram, 0.85 milligram, 1.25 milligrams, 1.21 milligrams, 0.35 milligram, 0.005 milligram, 0.005 milligram, 0.005 milligram, 0.005 milligram and 0.001 milli gram per centimeter 2/ hour.The velocity of diffusion of these prodrugs in human body skin medicine 350 times faster than retinoid medicine.Result illustrate, the positive charge on dialkyl amino ethyl to medicine through microbial film and skin barrier extremely important.
These novel prodrugs are evaluated by the following method to the hormesis of mouse skin or uncomfortable reaction, the various testing drug external applications 0.1 milliliter being dissolved in 1% of ethanol are applied to nude mice back, twice daily, these novel prodrugs of postevaluation in a week are to the hormesis of mouse skin or uncomfortable reaction.To N, N-diethyllaminoethyl-9-cis-retinoate. HBr, N, N-diethyllaminoethyl-retinoids ester hydrobromate, N, N-diethyllaminoethyl alltrans-retinoate, retinyl-N, N-dimethyl-2-aminoethyl hydrochloride, N, N-diethyllaminoethyl 4-[1-(5,6,7,8-tetrahydrochysene-3,5,5,8,8-pentamethyl--2-naphthyl) vinyl] benzoic ether hydrochloride do not find hormesis or uncomfortable reaction.
A good prodrug should change back to female medicine structure easily.In accordance with the following methods external plasma hydrolysis studies is carried out to these prodrugs.10 milligrams of prodrugs are dissolved in the phosphate buffer soln of 0.1 milliliter of 0.2MpH value 7.4.1 milliliter of human plasma is preheating to 37 DEG C, is added in mixture.Mixture is incubated in the water-bath of 37 DEG C.Every two minutes intervals, take out 0.2 ml sample and add 0.4 ml methanol and make plasma protein precipitate.Centrifugal 5 minutes of sample also uses efficient liquid phase chromatographic analysis.N, the transformation period of N-diethyllaminoethyl 9-cis-retinoate. HBr hydrolysis is 10 ± 1 minutes, N, the transformation period of N-diethyllaminoethyl retinoids ester hydrobromate hydrolysis is 8 ± 2 minutes, N, the transformation period of N-diethyllaminoethyl all-trans vitamin A acid ester hydrobromate hydrolysis is 9 ± 1 minutes, retinyl-N, the transformation period of N-dimethyl-2-glycine ester hydrochloride hydrolysis is 13 ± 2 minutes, N, N-diethyllaminoethyl-4-[1-(5, 6, 7, 8-tetrahydrochysene-3, 5, 5, 8, 8-pentamethyl--2-naphthyl) vinyl] benzoic ether hydrochloride hydrolysis transformation period be 11 ± 2 minutes.
Targretin (Bexarotene) optionally activates the subclass that a class is called as the retinoic acid receptor of RXR, and this receptor is played a part very important to permitting cellulous activity.Wherein a most important effect is exactly apoptosis, or " apoptosis ", and namely health removes the natural process of self unwanted cells.Ligand company is developing external application and the oral preparations of Targretin.External application Targretin can be used for treatment T-cell lymphoma,cutaneous (CTCL).In addition, Targretin oral formulation can be used for treating T-cell lymphoma,cutaneous (CTCL), incidence cancer, the Kaposi's sarcoma of general, lung cancer, ovarian cancer, prostate cancer and renal cell carcinoma.A Li retinoic acid (9-cis-retinoic acid) is a natural endogenous retinoic acid, it can in conjunction with and activate all known intracellular Vitamin A receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg).These acceptors once activate, then can be used as transcription factor in normal cell and tumour cell, regulate the genetic expression that can control cytodifferentiation and breeding.A Li retinoic acid can be used for treating Kaposi's sarcoma, the Kaposi's sarcoma relevant to acquired immune deficiency syndrome (AIDS), other skin carcinoma, mammary cancer and other cancer.
In order to evaluate the antitumour activity of these prodrugs, by the breast cancer cell of people, (BCAP-37, every mouse uses 3-4 millimeter 3tumor tissues) to implant nude mice (BALB) subcutaneous.After 1 day, smear the N of 50 microlitres 1% in region (near the foreleg) external application of implanting human breast cancer cell, the N of N-diethyllaminoethyl 9-cis-retinoate. HBr and 50 microlitres 1%, N-diethyllaminoethyl 4-[1-(5,6,7,8-tetrahydrochysene-3,5,5,8,8-pentamethyl--2-naphthyl) vinyl] benzoic ether hydrochloride, all be dissolved in the phosphate buffer soln (v/v, 70/30) of ethanol/0.2MpH value 7.4, every day smears twice.After 28 days, the Tumor incidence of nude mice of control group (n=7) is 100% (half equal tumor size is 13 ± 2 millimeters × 12 ± 2 centimetres), and administration N, N-diethyllaminoethyl 9-cis-retinoate. HBr or N, N-diethyllaminoethyl 4-[1-(5,6,7,8-tetrahydrochysene-3,5,5,8,8-pentamethyl--2-naphthyl) vinyl] the treatment group nude mice (n=7) of benzoic ether hydrochloride all do not observe tumour.Most importantly any discomfort or hormesis is not shown after nude mice administration.The nude mice mean body weight for the treatment of group is 25 ± 2 grams, and the nude mice mean body weight of blank group is 23 ± 3 grams.The side effect of these prodrugs of the results show is very slight.
In another experiment, by the colon cancer cell of people, (LS174J, every mouse uses 3-4 millimeter 3tumor tissues) to implant nude mice (BALB) subcutaneous.After 1 day, smear the N of 50 microlitres 1% in region (near the foreleg) external application of implanting human colon cancer cell, the N of N-diethyllaminoethyl 9-cis-retinoate. HBr and 50 microlitres 1%, N-diethyllaminoethyl 4-[1-(5,6,7,8-tetrahydrochysene-3,5,5,8,8-pentamethyl--2-naphthyl) vinyl] benzoic ether hydrochloride, all be dissolved in the phosphate buffer solution (v/v, 70/30) of ethanol/0.2MpH value 7.4, every day smears twice.After 28 days, the Tumor incidence of control group (n=7) is 100% (average tumor size is 22 ± 4 millimeters × 20 ± 3 millimeters), and administration N, N-diethyllaminoethyl 9-cis-retinoate. HBr or N, N-diethyllaminoethyl 4-[1-(5,6,7,8-tetrahydrochysene-3,5,5,8,8-pentamethyl--2-naphthyl) vinyl] treatment group (n=7) of benzoic ether hydrochloride all do not observe tumour.
All vitamins A acids can buy.Compound represented by above-mentioned general formula (1,2,3,5,6,7,8,9,10,11,12,16,17,22,23,24,25,26 or 27) " structural formula 1,2,3,5,6,7,8,9,10,11,12,16,17,22,23,24,25,26 or 27 " can react obtained by V-A acidic or its related compound under the effect of coupler with the compound represented by general formula (28) " structural formula 28 ".Coupler is such as: N, N '-Dicyclohexylcarbodiimide, N, N '-diisopropylcarbodiimide, O-(benzotriazole-1-base)-N, N, N ', N '-tetramethyl-urea Tetrafluoroboric acid ester, O-(benzotriazole-1-base)-N, N, N ', N '-tetramethyl-urea phosphofluoric acid ester, benzotriazole-1-base-oxygen-three (dimethylamino) phosphorus phosphofluoric acid ester etc.
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6' aryl or heteroaryl or other ring system groups substitute; X represents O, S or NH.
Compound represented by above-mentioned general formula (4,13,14,15,20 or 21) " structural formula 4,13,14,15,20 or 21 " can be obtained by reacting by the compound represented by vitamin A and related compound and general formula (29) " structural formula 29 " thereof
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; Z represents F, Cl, Br or I; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion.
When X represents O, the compound represented by above-mentioned general formula (1,2,3,5,6,7,8,9,10,11,12,16,17,22,23,24,25,26 or 27) " structural formula 1,2,3,5,6,7,8,9,10,11,12,16,17,22,23,24,25,26 or 27 " can be obtained by reacting by the compound represented by V-A acidic and the metal-salt of related compound, organic alkali salt or immobilized alkali salt and general formula (30) " structural formula 30 ".
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, alkyl, alkoxyl group, thiazolinyl, the alkynyl of arbitrary 1-12 carbon atom, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6' aryl or heteroaryl, or other ring system groups substitute; R 3represent H, alkyl, alkoxyl group, the alkenyl or alkynyl of arbitrary 1-12 carbon atom, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; Z represents F, Cl, Br or I, or p-toluenesulfonyl; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion.
Advantage
A fatty contents and a water-soluble portion (with the amido that protonated form exists under at physiological ph) is had in the pro-drugs of the V-A acidic in the present invention and retinoid acid compound.In these prodrugs, the amino of positively charged has two large advantages.First, it largely increases the solubleness of prodrug in water, when these prodrugs are with formulation transdermal administrations such as solution, spray, emulsion, ointment, latex or gels, it can mix with other portion faces moisture of skin, eyes, genital area, mouth, nose or health rapidly.The second, on these prodrug amino with positive charge can be combined with the negative charge of biomembranous phosphate head structure band.Therefore, the partial concn outside microbial film can be very high, thus promote that these prodrugs penetrate into low concentration region from area with high mercury.After these prodrugs enter into microbial film, hydrophilic parts can promote medicine and enter tenuigenin, a kind of concentrated semi liquid state aqueous solution or suspension.Due to very short in the residence time at skin, eyes, genital area, mouth, nose or other positions of health, prodrug can not cause itch, burning sensation or pain.The prodrug of experimental result display more than 90% can get back to female medicine in several minutes.Because prodrug has higher specific absorption and transdermal administration can avoid first pass metabolism, therefore when equal dose, these prodrugs are stronger than the effect of V-A acidic and retinoid acid compound.Another large benefit of these prodrug transdermal administrations is that medication is convenient, particularly gives children.
Accompanying drawing explanation
Fig. 1: by the N of the human skin tissue of separation in Franz pond (n=5), N-diethyllaminoethyl 9-cis-retinoate. HBr (5% solution, A), N, N-diethyllaminoethyl isotretinon ester hydrobromate (5% solution, B), N, N-diethyllaminoethyl all-trans vitamin A acid ester hydrobromate (5% solution, C), retinyl-N, N-dimethyl-2-aminoacetic acid ester hydrochloride (5% solution, D), N, N-diethyllaminoethyl 4-[1-(5, 6, 7, 8-tetrahydrochysene-3, 5, 5, 8, 8-pentamethyl--2-naphthyl) vinyl] benzene methyl hydrochloride (5% solution, E), 9-cis-retinoic acid (5% suspension, F), isotretinon (5% suspension, G), all-trans vitamin A acid (5% suspension, H), Vitamin A (5% suspension, I), with Bexarotene (5% mixed earnestly liquid, J).In each example, carrier soln is all the phosphate buffer soln (0.2M) (v/v, 70/30) of ethanol/pH value 7.4.
Fig. 2: structure 31, wherein, Ret represents the compound of V-A acidic and elliptic function-like solution; R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ..., aryl or heteroaryl; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, alkyl, alkoxyl group, the alkenyl or alkynyl of arbitrary 1-12 carbon atom, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 4r 3, aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, or aryl or heteroaryl; R 4represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, or aryl or heteroaryl; X represents O, S or NH; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; All R, R 1, R 2, R 3or-(CH 2) n-group is side chain or side chain, can comprise C, and H, O, S or atom N can have singly-bound, double bond and triple bond.
Preferred forms
The preparation of N, N-diethyllaminoethyl 9-cis-retinoate. HBr
32.2 grams of (0.1 mole) 9-cis vitamin A acid sodium are dissolved in 100 milliliters of acetonitriles.26.1 grams of bromo-N, N-diethylethylamine. HBr of (0.1 mole) 2-are added reaction mixture.At room temperature mixed solution stirs and spends the night.Solvent evaporated.200 milliliters of ethanol are added the mixture of evaporate to dryness.Solids removed by filtration.Evaporate to dryness filtrate.100 milliliters of ethyl acetate are added to reaction mixture.Add 100 milliliters of hexanes.Solid collected by filtration product.Drying, obtains 36 grams of desired products (productive rate is 75%).Easy absorbent product; Ultimate analysis: C 26h 42brNO 2; Molecular weight: 480.52.Theoretical value %C:64.99; H:8.81; Br:16.63; N:2.91; O:6.66; Measured value %C:65.03; H:8.80; Br:16.60; N:2.89; O:6.68.
Embodiment
The preparation of N, N-diethyllaminoethyl retinoids ester hydrobromate
32.2 grams of (0.1 mole) retinoids sodium are dissolved in 100 milliliters of acetonitriles.26.1 grams of bromo-N, N-diethylethylamine. HBr of (0.1 mole) 2-are added reaction mixture.At room temperature mixed solution is stirred and spend the night.Solvent evaporated.200 milliliters of ethanol are added the mixture of evaporate to dryness.Solids removed by filtration.Evaporate to dryness filtrate.100 milliliters of ethyl acetate are added to reaction mixture.Add 100 milliliters of hexanes.Solid collected by filtration product.Drying, obtains 38 grams of desired products (productive rate is 79.1%).Easy absorbent product; Ultimate analysis: C 26h 42brNO 2; Molecular weight: 480.52.Theoretical value %C:64.99; H:8.81; Br:16.63; N:2.91; O:6.66; Measured value %C:65.03; H:8.80; Br:16.60; N:2.89; O:6.68.
N, N-diethyllaminoethyl is complete-preparation of trans-retinoate
Complete to 32.2 grams (0.1 moles)-Trans-Retinoic Acid sodium is dissolved in 100 milliliters of acetonitriles.26.1 grams of bromo-N, N-diethylethylamine. HBr of (0.1 mole) 2-are added reaction mixture.At room temperature mixed solution is stirred and spend the night.Solvent evaporated.200 milliliters of ethanol are added the mixture of evaporate to dryness.Solids removed by filtration.Evaporate to dryness filtrate.100 milliliters of ethyl acetate are added to reaction mixture.Add 100 milliliters of hexanes.Solid collected by filtration product.Drying, obtains 35 grams of desired products (productive rate is 72.9%).Easy absorbent product; Ultimate analysis: C 26h 42brNO 2; Molecular weight: 480.52.Theoretical value %C:64.99; H:8.81; Br:16.63; N:2.91; O:6.66; Measured value %C:65.03; H:8.80; Br:16.60; N:2.89; O:6.68.
N, N dimethylamine guanidine-acetic acid looks the preparation of Huang (vitamin A) ester hydrochloride
28.6 grams of (0.1 mole) vitamin A are dissolved in 100 milliliters of acetonitriles.25 milliliters of triethylamines join in this reaction solution.16 grams of N, N dimethylamine base acetyl chloride hydrochloride adds reaction mixture.At room temperature mixed solution is stirred 5 hours.Solids removed by filtration.Evaporate to dryness filtrate.500 milliliters of ethyl acetate are added in residuum.Under agitation in mixed solution, add 200 milliliter of 5% sodium carbonate solution.Collect organic solution and wash with water and (after evaporate to dryness, obtain 31 grams of desired products (productive rate is 75.5%).Easy absorbent product; Ultimate analysis: C 24h 38clNO 2; Molecular weight: 408.02.Theoretical value %C:70.65; H:9.39; Cl:8.69; N:3.43; O:7.84; Measured value %C:70.60; H:9.46; Cl:8.71; N:3.42; O:7.81.
The preparation of N, N-diethyllaminoethyl 4-[1-(5,6,7,8-tetrahydrochysene-3,5,5,8,8-pentamethyl--2-naphthyl) vinyl] benzoic ether hydrochloride
34.9 grams of (0.1 mole) 4-[1-(5,6,7,8-tetrahydrochysene-3,5,5,8,8-pentamethyl--2-naphthyl) vinyl] phenylformic acid (Bexarotene, Targretin) is dissolved in 300 milliliters of chloroforms.20.6 grams of (0.1 mole) N, N '-Dicyclohexylcarbodiimide are joined reaction mixture.11.6 grams of dimethylamino-ethanols are joined in reaction mixture.Mixed solution at room temperature stirs 3 hours.Solids removed by filtration.Chloroformic solution 5%NaHCO 3(2 × 100 milliliters) and water (3 × 100 milliliters) wash.Organic solution anhydrous sodium sulfate drying.Cross and filter sodium sulfate.Under agitation the 3.6 grams of HCl gases be dissolved in 100 milliliters of ether are joined in reaction mixture.Solid collected by filtration product.After drying, obtain 40 grams of desired products (productive rate is 85.8%).Easy absorbent product; Ultimate analysis: C 30h 42clNO 2; Molecular weight: 484.11.Theoretical value %C:74.43; H:8.74; Cl:7.32; N:2.89; O:6.61; Measured value %C:74.39; H:8.76; Cl:7.29; N:2.91; O:6.65.
Industrial applicibility
These prodrugs that general formula (1-27) " structural formula 1-27 " represents are better than V-A acidic and retinoid acid compound.They may be used for the treatment any available V-A acidic of human or animal and the state of elliptic function-like solution compounds for treating.They can be used for Acne treatment, acne scars, psoriasis, ichthyosis, eczema, keratinization disorders, precancerous lesion, chemoprophylaxis, wart, sarcoidosis, treats skin photo-ageing, prevents skin photo-ageing, aging, the alopecia for the treatment of chronic skin and various cancer.

Claims (39)

1. the compound represented by general formula (1) " structural formula 1 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 6represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 6, COR 6, COOR 6, NR 6cOR 7, SOR 6, SR 6, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6and R 6' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 7cOR 5, SOR 5, SR 5, PO 3r 7r 7', the alkyl of arbitrary 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 7r 7', aryl or heteroaryl, or other ring system groups substitute; R 7and R 7' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of arbitrary 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
2. a kind of compound as claimed in claim 1, it is N, N-diethyllaminoethyl 9-cis vitamin A acid ester .HA salt, wherein, A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion.
3. the compound represented by general formula (2) " structural formula 2 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 6represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 6, COR 6, COOR 6, NR 6cOR 7, SOR 6, SR 6, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6and R 6' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 7cOR 5, SOR 5, SR 5, PO 3r 7r 7', the alkyl of arbitrary 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 7r 7', aryl or heteroaryl, or other ring system groups substitute; R 7and R 7' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of arbitrary 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
4. a kind of compound as claimed in claim 3, it is N, N-diethyllaminoethyl retinoids ester .HA salt, wherein, A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion.
5. the compound represented by general formula (3) " structural formula 3 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 6represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 6, COR 6, COOR 6, NR 6cOR 7, SOR 6, SR 6, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6and R 6' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 7cOR 5, SOR 5, SR 5, PO 3r 7r 7', the alkyl of arbitrary 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 7r 7', aryl or heteroaryl, or other ring system groups substitute; R 7and R 7' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of arbitrary 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
6. a kind of compound as claimed in claim 5, its be N, N-diethyllaminoethyl complete-Trans-Retinoic Acid ester .HA salt, wherein A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion.
7. the compound represented by general formula (4) " structural formula 4 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10......, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 6, COR 6, COOR 6, NR 6cOR 7, SOR 6, SR 6, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6and R 6' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 7cOR 5, SOR 5, SR 5, PO 3r 7r 7', the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 7r 7', aryl or heteroaryl, or other ring system groups substitute; R 7and R 7' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of arbitrary 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 6represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
8. a kind of compound as claimed in claim 7, it is retinyl-N, N-dimethyl-2-amino ethyl ester HA salt, A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion.
9. the compound represented by general formula (5) " structural formula 5 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,1O ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 6, COR 6, COOR 6, NR 6cOR 7, SOR 6, SR 6, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6and R 6' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 7cOR 5, SOR 5, SR 5, PO 3r 7r 7', the alkyl of arbitrary 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 7r 7', aryl or heteroaryl, or other ring system groups substitute; R 7and R 7' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of arbitrary 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6' aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
10. a kind of compound as claimed in claim 9, it is N, N-diethyllaminoethyl 4-[1-(5,6,7,8-tetra-oxygen-3,5,5,8,8-pentamethyl--2-naphthyl) vinyl] benzoic ether .HA salt, wherein A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion.
Compound represented by 11. general formulas (6) " structural formula 6 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 6, COR 6, COOR 6, NR 6cOR 7, SOR 6, SR 6, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 11represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 12represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6and R 6' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 7cOR 5, SOR 5, SR 5, PO 3r 7r 7', the alkyl of arbitrary 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 7r 7', aryl or heteroaryl, or other ring system groups substitute; R 7and R 7' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; T represents CH 2=C, CH=CH, C (CH 3)=CH, C ≡ C, C=O, C=S, CONH, CSNH, COO, OCO, COS, COCH 2or CH 2cO; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
12. compounds represented by general formula (7) " structural formula 7 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 6, COR 6, COOR 6, NR 6cOR 7, SOR 6, SR 6, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 9represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 10represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6and R 6' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 7cOR 5, SOR 5, SR 5, PO 3r 7r 7', the alkyl of arbitrary 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 7r 7', aryl or heteroaryl, or other ring system groups substitute; R 7and R 7' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 8and R 8' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
13. compounds represented by general formula (8) " structural formula 8 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 6, COR 6, COOR 6, NR 6cOR 7, SOR 6, SR 6, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 10represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6and R 6' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 7cOR 5, SOR 5, SR 5, PO 3r 7r 7', the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 7r 7', aryl or heteroaryl, or other ring system groups substitute; R 7and R 7' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 8and R 8' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 9and R 9' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
14. compounds represented by general formula (9) " structural formula 9 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6' aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4, R 5, R 7, R 8, R 10, and R 11can represent identical or different group, can be H, OH, C1, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6and R 6' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 9cOR 5, SOR 5, SR 5, PO 3r 9r 9', the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 9r 9', aryl or heteroaryl, or other ring system groups substitute; R 9and R 9' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
15. compounds represented by general formula (10) " structural formula 10 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4, R 5, R 7, R 8, R 9, R 10and R 11can represent identical or different group, can be H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6and R 6' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 12cOR 5, SOR 5, SR 5, PO 3r 12r 12', the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 9r 9', aryl or heteroaryl, or other ring system groups substitute; R 12and R 12' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
16. compounds represented by general formula (11) " structural formula 11 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 6, COR 6, COOR 6, NR 6cOR 7, SOR 6, SR 6, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 7represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 9represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 10represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 11represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6and R 6' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 8cOR 5, SOR 5, SR 5, PO 3r 8r 8', the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 8r 8', aryl or heteroaryl, or other ring system groups substitute; R 8and R 8' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
17. compounds represented by general formula (12) " structural formula 12 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or it is with representative-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 6, COR 6, COOR 6, NR 6cOR 7, SOR 6, SR 6, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 7represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 10represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 11represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6and R 6' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 8cOR 5, SOR 5, SR 5, PO 3r 8r 8', the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 8r 8', aryl or heteroaryl, or other ring system groups substitute; R 8and R 8' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 9and R 9' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
18. compounds represented by general formula 13 " structural formula 13 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 7, aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 7, aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 6, COR 6, COOR 6, NR 6cOR 7, SOR 6, SR 6, PO 3r 6r 7, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 7represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 8represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 9represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 10represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 11represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 12represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
19. compounds represented by general formula (14) " structural formula 14 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 7, aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 7, aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 6, COR 6, COOR 6, NR 6cOR 7, SOR 6, SR 6, PO 3r 6r 7, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 7represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 8represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 9represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 10represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 7, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
20. compounds represented by general formula (15) " structural formula 15 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6' aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 6represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 6, COR 6, COOR 6, NR 6cOR 6, SOR 6, SR 6, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 6, COR 6, COOR 6, NR 6cOR 6, SOR 6, SR 6, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 5cOR 4, SOR 5, SR 5, PO 3r 5r 4, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6and R 6' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 4cOR 5, SOR 5, SR 5, PO 3r 4r 5, the alkyl of a 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 4r 5, aryl or heteroaryl, or other ring system groups substitute; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
21. compounds represented by general formula (16) " structural formula 16 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 5, aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 5, aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 5, aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 6, COR 6, COOR 6, NR 6cOR 7, SOR 6, SR 6, PO 3r 6r 4, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 4cOR 5, SOR 5, SR 5, PO 3r 4r 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 7represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 8represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 4cOR 5, SOR 5, SR 5, PO 3r 4r 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 9represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 10represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
22. compounds represented by general formula (17) " structural formula 17 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 5, aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 5, aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 5, aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 5, SOR 5, SR 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 5, SOR 5, SR 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 6, COR 6, COOR 6, NR 6cOR 7, SOR 6, SR 6, PO 3r 6r 4, SOR 6, SR 6, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 4cOR 5, SOR 5, SR 5, PO 3r 4r 5, SOR 5, SR 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 7represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 5, SOR 5, SR 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 8represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 4cOR 5, SOR 5, SR 5, PO 3r 4r 5, SOR 5, SR 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 9represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 5, SOR 5, SR 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 10represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 5, SOR 5, SR 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
23. compounds represented by general formula (18) " structural formula 18 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2x 5, COX 5, COOX 5, NX 6cOX 5, SOX 5, SX 5, PO 3x 6x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 5, COX 5, COOX 5, NX 6cOX 5, SOX 5, SX 5, PO 3x 6x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 5, COX 5, COOX 5, NX 6cOX 5, SOX 5, SX 5, PO 3x 6x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 5, COX 5, COOX 5, NX 6cOX 5, SOX 5, SX 5, PO 3x 6x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 4, COX 4, COOX 4, NX 6cOX 4, SOX 4, SX 4, PO 3x 6x 4, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 6represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 5, COX 5, COOX 5, NX 4cOX 5, SOX 5, SX 5, PO 3x 4x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
24. compounds represented by general formula (19) " structural formula 19 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2x 5, COX 5, COOX 5, NX 6cOX 5, SOX 5, SX 5, PO 3x 6x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 5, COX 5, COOX 5, NX 6cOX 5, SOX 5, SX 5, PO 3x 6x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 5, COX 5, COOX 5, NX 6cOX 5, SOX 5, SX 5, PO 3x 6x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 5, COX 5, COOX 5, NX 6cOX 5, SOX 5, SX 5, PO 3x 6x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 4, COX 4, COOX 4, NX 6cOX 4, SOX 4, SX 4, PO 3x 6x 4, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 6represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 5, COX 5, COOX 5, NX 4cOX 5, SOX 5, SX 5, PO 3x 4x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 5x 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 4, COR 4, COOR 4, NR 4cOX 5, SOR 4, SR 4, PO 3r 4x 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
25. compounds represented by general formula (20) " structural formula 20 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2x 5, COX 5, COOX 5, NX 6cOX 5, SOX 5, SX 5, PO 3x 6x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 5, COX 5, COOX 5, NX 6cOX 5, SOX 5, SX 5, PO 3x 6x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 5, COX 5, COOX 5, NX 6cOX 5, SOX 5, SX 5, PO 3x 6x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 5, COX 5, COOX 5, NX 6cOX 5, SOX 5, SX 5, PO 3x 6x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 4, COX 4, COOX 4, NX 6cOX 4, SOX 4, SX 4, PO 3x 6x 4, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 6represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 5, COX 5, COOX 5, NX 4cOX 5, SOX 5, SX 5, PO 3x 4x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 5, COX 5, COOX 5, NX 6cOX 5, SOX 5, SX 5, PO 3x 4x 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 4, COX 4, COOX 4, NX 4cOX 5, SOX 4, SX 4, PO 3x 4x 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
26. compounds represented by general formula (21) " structural formula 21 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2x 5, COX 5, COOX 5, NX 6cOX 5, SOX 5, SX 5, PO 3x 6x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 5, COX 5, COOX 5, NX 6cOX 5, SOX 5, SX 5, PO 3x 6x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 5, COX 5, COOX 5, NX 6cOX 5, SOX 5, SX 5, PO 3x 6x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 5, COX 5, COOX 5, NX 6cOX 5, SOX 5, SX 5, PO 3x 6x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 4, COX 4, COOX 4, NX 6cOX 4, SOX 4, SX 4, PO 3x 6x 4, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 6represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 5, COX 5, COOX 5, NX 4cOX 5, SOX 5, SX 5, PO 3x 4x 5, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 5x 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 4, COR 4, COOR 4, NR 4cOX 1, SOR 4, SR 4, PO 3r 4x 1, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
27. compounds represented by general formula (22) " structural formula 22 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2x 2, COX 2, COOX 5, NX 2cOX 3, SOX 2, SX 3, PO 3x 2x 3, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 3, SOX 1, SX 1, PO 3x 1x 3, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 1, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 2, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 2, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 4, COR 4, COOR 4, NR 4cOX 1, SOR 4, SR 4, PO 3r 4x 1, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
28. compounds represented by general formula (23) " structural formula 23 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2x 2, COX 2, COOX 5, NX 2cOX 3, SOX 2, SX 3, PO 3x 2x 3, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 3, SOX 1, SX 1, PO 3x 1x 3, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 1, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 2, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or a heatable brick bed oxygen base of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 2, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, a heatable brick bed oxygen base of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 4, COR 4, COOR 4, NR 4cOX 1, SOR 4, SR 4, PO 3r 4x 1, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluor a heatable brick bed base of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
29. compounds represented by general formula (24) " structural formula 24 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, a heatable brick bed base of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2x 2, COX 2, COOX 5, NX 2cOX 3, SOX 2, SX 3, PO 3x 2x 3, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 3, SOX 1, SX 1, PO 3x 1x 3, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 1, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom a heatable brick bed base, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 2, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 4, COX 4, COOX 4, NX 1cOX 4, SOX 4, SX 4, PO 3x 1x 4, a 1-6 carbon atom alkyl, the perfluor a heatable brick bed base of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 2, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 4, COR 4, COOR 4, NR 4cOX 5, SOR 4, SR 4, PO 3r 4x 5, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
30. compounds represented by general formula (25) " structural formula 25 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 3represent H, a heatable brick bed base of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2x 2, COX 2, COOX 5, NX 2cOX 3, SOX 2, SX 3, PO 3x 2x 3, a 1-6 carbon atom a heatable brick bed base, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 3, SOX 1, SX 1, PO 3x 1x 3, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 1, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 2, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 4, COX 4, COOX 4, NX 1cOX 4, SOX 4, SX 4, PO 3x 1x 4, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 2, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 4, COR 4, COOR 4, NR 4cOX 1, SOR 4, SR 4, PO 3r 4x 1, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 11represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 4, COR 4, COOR 4, NR 4cOX 1, SOR 4, SR 4, PO 3r 4x 1, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
31. compounds represented by general formula (26) " structural formula 26 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 3represent H, a heatable brick bed base of arbitrary 1-12 carbon atom, a heatable brick bed oxygen base, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2x 2, COX 2, COOX 5, NX 2cOX 3, SOX 2, SX 3, PO 3x 2x 3, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 3, SOX 1, SX 1, PO 3x 1x 3, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 1, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 2, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or a heatable brick bed oxygen base of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 4, COX 4, COOX 4, NX 1cOX 4, SOX 4, SX 4, PO 3x 1x 4, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 2, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; T represents CH 2=C, CH=CH, C (CH 3)=CH, C ≡ C, C=O, C=S, CONH, CSNH, COO, OCO, COS, COCH 2or CH 2cO; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
32. compounds represented by general formula (27) " structural formula 27 ",
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CX 1x 2, aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; X 1represent H, OH, Cl, Br, F, I, NO 2, NO, CN, SO 2x 2, COX 2, COOX 5, NX 2cOX 3, SOX 2, SX 3, PO 3x 2x 3, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 2represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 3, SOX 1, SX 1, PO 3x 1x 3, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 3represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 1, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 2, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, 1-6 carbon atom with fluoroalkyl, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 4, COX 4, COOX 4, NX 1cOX 4, SOX 4, SX 4, PO 3x 1x 4, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; X 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 4, COX 4, COOX 4, NX 1cOX 4, SOX 4, SX 4, PO 3x 1x 4, a 1-6 carbon atom alkyl, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the alkoxyl group of 1-6 carbon atom; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 2, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 2, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 2, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 7represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 2, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 8represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2x 1, COX 1, COOX 1, NX 1cOX 2, SOX 1, SX 1, PO 3x 1x 2, a 1-6 carbon atom alkyl, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can sufficient Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
33. as claim 1, 2, 3, 4, 5, 6, 9, 10, 11, 12, 13, 14, 15, 16, 17, 21, 22, 27, 28, 29, 30, general formula (1 described in 31 and 32, 2, 3, 5, 6, 7, 8, 9, 10, 11, 12, 16, 17, 22, 23, 24, 25, 26 and 27) " structural formula 1, 2, 3, 5, 6, 7, 8, 9, 10, 11, 12, 16, 17, 22, 23, 24, 25, the synthetic method of the compound 26 and 27 ", wherein said compound can react obtained by retinoic acid compounds and related compound thereof under the effect of coupler with the compound represented by general formula (28) " structural formula 28 ", coupling agent has: N, N '-Dicyclohexylcarbodiimide, N, N '-diisopropylcarbodiimide, O-(benzotriazole-1-base)-N, N, N ', N '-tetramethyl-urea Tetrafluoroboric acid ester, O-(benzotriazole-1-base)-N, N, N ', N '-tetramethyl-urea phosphofluoric acid ester, benzotriazole-1-base-oxygen base-three (dimethylamino) phosphorus phosphofluoric acid ester (HBTU) etc.,
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can be H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 4, COR 4, COOR 4, NR 6cOR 4, SOR 4, SR 4, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6and R 6' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 4cOR 5, SOR 5, SR 5, PO 3r 5r 4, the alkyl of arbitrary 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 4r 5, aryl or heteroaryl, or other ring system groups substitute; X represents O, S or NH; Double bond on side chain can sufficient Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
34. as claim 7, and 8,18,19,20,23,24, general formula (4,13,14 described in 25 and 26,15,20, and 21) synthetic method of the compound represented by " structural formula 4; 13,14,15; 20 or 21 ", wherein said compound can be obtained by reacting by the compound represented by retinoid and related compound and general formula (29) " structural formula 29 " thereof
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can the alkyl of sufficient H, an arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 4, COR 4, COOR 4, NR 6cOR 4, SOR 4, SR 4, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6and R 6' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 4cOR 5, SOR 5, SR 5, PO 3r 5r 4, the alkyl of arbitrary 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 4r 5, aryl or heteroaryl, or other ring system groups substitute; Z represents F, Cl, Br, or I; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
35. as claim 1, 2, 3, 4, 5, 6, 9, 10, 11, 12, 13, 14, 15, 16, 17, 21, 22, 27, 28, 29, 30, general formula (1 described in 31 and 32, 2, 3, 5, 6, 7, 8, 9, 10, 11, 12, 16, 17, 22, 23, 24, 25, 26 and 27) " structural formula 1, 2, 3, 5, 6, 7, 8, 9, 10, 11, 12, 16, 17, 22, 23, 24, 25, the synthetic method of the compound 26 and 27 ", wherein when X represents O, described compound can by the metal-salt of retinoic acid or its related compound, organic alkali salt or immobilization alkali salt and the compound represented by general formula (30) " structural formula 30 " react obtained:
Wherein, R represents straight or branched ,-(CH 2) n-, wherein n=0,1,2,3,4,5,6,7,8,9,10 ... ,-(CH 2) n-in, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 1and R 2respective independent Shi Ke represents identical or different group, can the alkyl of sufficient H, an arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, or common designation-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 3represent H, the alkyl of arbitrary 1-12 carbon atom, alkoxyl group, thiazolinyl or alkynyl, aryl or heteroaryl, wherein, any CH 2can by O, S, CH=CH, C ≡ C, CR 6r 6', aryl or heteroaryl, or other ring system groups substitute; R 4represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 6cOR 5, SOR 5, SR 5, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 5represent H, OH, Cl, Br, F, I, NO 2, CN, SO 2r 4, COR 4, COOR 4, NR 6cOR 4, SOR 4, SR 4, PO 3r 6r 6', the alkyl of a 1-6 carbon atom, the alkoxyl group of 1-6 carbon atom, the perfluoroalkyl of 1-6 carbon atom, the thiazolinyl of 1-6 carbon atom, the alkynyl of 1-6 carbon atom, or the haloalkyl of 1-6 carbon atom; R 6and R 6' respective independent Shi Ke represents identical or different group, can be H, Cl, Br, F, I, OH, NO 2, CN, SO 2r 5, COR 5, COOR 5, NR 4cOR 5, SOR 5, SR 5, PO 3r 5r 4, the alkyl of arbitrary 1-6 carbon atom, the alkoxyl group of a 1-6 carbon atom, the thiazolinyl of a 1-6 carbon atom, the alkynyl of a 1-6 carbon atom, or haloalkyl, or common designation oxygen (=O) or-(CH 2) n-, wherein n=2,3,4,5,6,7,8,9,10 ..., any CH 2can by O, S, CH=CH, C ≡ C, CR 4r 5, aryl or heteroaryl, or other ring system groups substitute; Z represents halogen, or p-toluenesulfonyl; A -represent Cl -, Br -, F -, I -, AcO -, citrate, or any negative ion; Double bond on side chain can be Z or E; All R, R 1, R 2, R 3, R 4, or-(CH 2) n-group can be side chain or straight chain, can comprise C, H, O, S, N and other atoms, can contain singly-bound, double bond, triple bond and ring system.
36. compounds as described in Claim 1-3 2 represented by general formula (1 to 27) " structural formula 1 to 27 " or at least containing the composition of the compound represented by a kind of general formula (1 to 27) " structural formula 1 to 27 " as activeconstituents, its by oral or transdermal administration for treating the state of the compounds for treating of any available V-A acidic and elliptic function-like solution in human or animal; The state of the compounds-treatable of V-A acidic and elliptic function-like solution includes but not limited to: acne, acne scars, psoriasis, ichthyosis, eczema, keratinization disorders, precancerous lesion, chemoprophylaxis, wart, sarcoidosis, treatment skin photoage, prevention skin photoage, aging, the alopecia for the treatment of chronic skin and various cancers etc.
The method of the 37. treatment any available V-A acidics of human or animal and the compounds-treatable conditions of elliptic function-like solution, the method by the compound represented by the general formula (1 to 27) " structural formula 1 to 27 " of health any part transdermal administration (external application) as described in Claim 1-3 2 as activeconstituents, and reach treatment effective concentration, wherein Transdermal delivery systems comprises solution, spray, emulsion, ointment, latex or gel.
The acne of 38. external curing human or animals, acne scars, psoriasis, ichthyosis, eczema, keratinization disorders, precancerous lesion, chemoprophylaxis, wart, sarcoidosis, treatment photoaged skin, prevention skin photoage, the method for aging, the alopecia for the treatment of chronic skin and various cancer, the method by the compound represented by the general formula (1 to 27) " structural formula 1 to 27 " as described in Claim 1-3 2 that gives effective therapeutic dose in disease area as activeconstituents.
39. skin-penetrating therapeutic application systems, containing the compound as described in Claim 1-3 2 represented by general formula (1 to 27) " structural formula 1 to 27 " as activeconstituents, can be used for the state for the treatment of any V-A acidic of human or animal and the compounds-treatable of elliptic function-like solution; The above system can be bandage or paster, and it contains one and comprises the hypothallus of active substance and the protective layer of an impermeable, and most preferred system is an active substance reservoir, containing a permeable bottom towards skin; By Co ntrolled release speed, this system can make the stability of compounds of V-A acidic and elliptic function-like solution in optimal treatment Plasma Concentration thus improve the side effect that curative effect increases the compound of curative effect and minimizing V-A acidic and elliptic function-like solution.
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