CN105435309A - Composite tissue repairing sheet and preparation method thereof - Google Patents
Composite tissue repairing sheet and preparation method thereof Download PDFInfo
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- CN105435309A CN105435309A CN201510966930.7A CN201510966930A CN105435309A CN 105435309 A CN105435309 A CN 105435309A CN 201510966930 A CN201510966930 A CN 201510966930A CN 105435309 A CN105435309 A CN 105435309A
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- electrostatic spinning
- tissue repairing
- repairing patch
- compound tissue
- rete
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
Abstract
The invention discloses a composite tissue repairing sheet and a preparation method thereof. The composite tissue repairing sheet comprises an electrostatic spinning film layer, a bonding layer and a woven mesh layer; the electrostatic spinning film layer is prepared from a material A, the bonding layer is prepared from a material B through electrostatic spinning, and the hot melting temperature of the material B is lower than the hot melting temperature of the material A; and the bonding layer is disposed between the electrostatic spinning film layer and the woven mesh layer, and the bonding layer is heated and melt through hot press, and thus the electrostatic spinning film layer is bonded with the woven mesh layer. The prepared composite tissue repairing sheet possesses good mechanical properties of a woven mesh and the three-dimensional porous structure and the soft characteristic of the electrostatic spinning film, facilitates to promote rapid growth of cell in the sheet, and possesses relatively good fusion property with hyperplastic tissue.
Description
Technical field
The present invention relates to biomedical sector, more particularly relate to a kind of compound tissue repairing patch and preparation method thereof.
Background technology
Electrospinning film has a wide range of applications in tissue repair, but due to its limitation in intensity, is such as requiring the higher rarely seen report of disease application aspect at abdominal hernia, shoulder sleeve etc. to the strength of materials.Main material at present for above-mentioned two kinds of diseases still weaves mesh sheet.But although braiding mesh sheet has good mechanical property, it exists in promotion tissue repair, and hardness is large, rough surface, easily and tissue adhesion, with the defect such as tissue fusion is bad, be difficult to obtain desirable repairing effect.Therefore, need a kind of compound tissue repairing patch, make its mechanical strength advantage combining braiding mesh sheet and static spinning membrane promote the advantage in tissue repair, thus can be used for abdominal hernia, shoulder sleeve etc. require higher position tissue repair to the strength of materials.
Electrospinning film and the method for braiding mesh sheet compound are mainly direct hot pressing and bonding by tradition.Long-term implant into body is carried out to the reparation goods of tissue repair, have higher requirement to material, material therefor is necessary for the human implantable material through approval.Because electrospinning membrane material is general and there is larger modulus difference between braiding mesh sheet, adopt the mode of conventional direct hot binding to be directly connected with braiding mesh sheet by electrospinning film and then easily occur to combine loosely, layering will occur under less external tensile force.Simultaneously, carry out direct hot binding to electrospinning film and braiding mesh sheet, processing technique is difficult to control, and easily destroys the structure of electrospinning film or braiding mesh sheet, thus cause the repairing performance decline of electrospinning film or the mechanical strength loss of braiding mesh sheet, desirable compound film sheet can not be obtained.
Summary of the invention
The present invention is intended to the defect overcoming above-mentioned prior art, provides a kind of compound tissue repairing patch.Described compound tissue repairing patch has the braiding good mechanical property of mesh sheet and the three-dimensional porous structure of static spinning membrane and flexible nature concurrently; And static spinning membrane is combined closely with braiding mesh sheet, not easily layering.
Another object of the present invention is to the preparation method that described compound tissue repairing patch is provided.
Another object of the present invention is to the application that described compound tissue repairing patch is provided.
Foregoing invention object of the present invention is achieved by following technical solution.
A kind of compound tissue repairing patch, comprises electrostatic spinning rete, adhesive layer, mesh grid lamella; Described electrostatic spinning rete is made up of materials A, and described adhesive layer is made up through electrostatic spinning of material B, and the hot melting temperature of described material B is lower than the hot melting temperature of materials A; Adhesive layer is placed between electrostatic spinning rete and mesh grid lamella, then makes described adhesive layer hot melt by hot pressing, make described electrostatic spinning rete and mesh grid lamella bonding.
The adhesive layer of the method for the invention, have employed the material of hot melting temperature lower than electrostatic spinning rete, therefore its hot melt can not affect the original structure of static spinning membrane, remain static spinning membrane better and be beneficial to the characteristic that cell grows into, by the mode of hot pressing, the adhesive layer of hot melt is embedded in the hole of electrostatic spinning rete and mesh grid lamella, makes it be bonded together, thus make can combine closely between electrostatic spinning rete and mesh grid lamella, not easily layering.
Preferably, the fiber interweaving that described electrostatic spinning rete is 10nm ~ 100 μm by diameter forms, and has three-dimensional porous structure.Electrostatic spinning rete prepared by electrospinning process, owing to having the features such as great specific surface area, high porosity and high surface energy, can imitate natural extracellular matrix from nanoscale, can be used as the porous support of Growth of Cells, promotes migration and the propagation of cell.There is the electrostatic spinning rete of three-dimensional porous structure, be easier to carry nutrition and oxygen in order to the propagation of cell and differentiation.
In the present invention, described materials A, the material of material B and formation braiding mesh sheet, is human implantable material.
Preferably, described electrostatic spinning rete A material therefor is polylactic acid (PLA), PGA (PGA), one or more in polyvinylidene fluoride (PVDF).
Preferably, adhesive layer material therefor is degradation material, such as polycaprolactone (PCL) or poly-4 butyric esters (P4HB).The degradation material that the hot melting temperature of PCL, P4HB is more general is low, and can carry out electrostatic spinning, is all the degradation material that approval can be used for implant into body.
Preferably, mesh grid lamella material therefor is polypropylene (PP), polyvinylidene fluoride (PVDF), one or more in polyethylene terephthalate (PET) or polytetrafluoroethylene (PTFE).
Compound tissue repairing patch of the present invention, it can be three-decker, or multiple structure, such as five-layer structure, when described compound tissue repairing patch is five-layer structure, be preferably made up of the first electrostatic spinning rete, the first adhesive layer, mesh grid lamella, the second adhesive layer, the second electrostatic spinning rete successively.
In order to improve the effect of tissue repair better, preferably, at least one deck static spinning membrane layer for being loaded with the electrostatic spinning layer of medicine.Described medicine can be antitumor, anti-infection drug, adherence preventing material or anticoagulant material, and other drug.Electrostatic spinning rete loads medicine, and compound tissue repairing patch, not only as sticking patch, simultaneously also as a kind of pharmaceutical carrier, can reduce drug degradation and loss, reduces side effect, improves bioavailability.When having adhered to above-mentioned adherence preventing material (as chitosan) or anticoagulant material (as PEO copolymer), can prevent the operative site constant pain brought by postoperative tissue adhesion or operative site part from losing the sequela such as function, having promoted wound healing.
In order to prevent the operative site constant pain brought by postoperative tissue adhesion or operative site part from losing the sequela such as function, promote wound healing, preferably, the outer surface of described electrostatic spinning layer is also coated with anti and/or anticoagulant coatings.
The preparation method of described compound tissue repairing patch, comprises the steps:
S1. the static spinning membrane be made up of materials A is prepared;
S2. the static spinning membrane be made up of material B is prepared;
S3. be placed on by the static spinning membrane of S2 between the static spinning membrane of S1 and braiding mesh sheet, hot pressing, makes the static spinning membrane hot melt of S2, makes the static spinning membrane of S1 bonding with mesh grid lamella.
Preferably, described hot pressing is carried out under the following conditions: temperature is 40 DEG C ~ 90 DEG C, and pressure is 0.4 ~ 1.3MPa, and hot pressing time is 2 ~ 10min.Preferably, the condition of electrostatic spinning described in described step S1, S2 is the speed of micro-injection pump is 0.1 ~ 15.0mL/h, and the voltage of high tension generator is 5 ~ 45KV, and the receiving range of receiving system is 5.0 ~ 30.0cm.
Preferably, the step loading medicine in the static spinning membrane of S1 is also included in.
Preferably, the top layer being also included in described compound tissue repairing patch arranges the step of anti and/or anticoagulant coatings.
As a kind of preferred version, the preparation method of described compound tissue repairing patch, also comprises the steps:
S4., between the static spinning membrane static spinning membrane of S2 being placed on two panels S1, hot pressing, makes the static spinning membrane hot melt of S2, makes the static spinning membrane of two panels S1 bonding;
And/or
S5. be placed on by the static spinning membrane of S2 between two panels braiding mesh sheet, hot pressing, makes the static spinning membrane hot melt of S2, makes two panels weave mesh sheet bonding.
Described compound tissue repairing patch repairs the application in reparation goods at the bottom of goods, hernia reparation goods and/or basin at shoulder sleeve.
Compared with prior art, the present invention has following beneficial effect:
Compound tissue repairing patch prepared by the present invention has the braiding good mechanical property of mesh sheet and the three-dimensional porous structure of static spinning membrane and flexible nature, static spinning membrane and the strong bonded weaving mesh sheet, the microstructure of static spinning membrane obtains good reservation, has better repairing effect.The present invention is in the process of compound tissue repairing patch, introduce the adhesive layer that electrostatic spinning is made, it is compared to existing medical material adhesive layer, there is three-dimensional porous structure, even if also there is certain hole after hot melt adhesive, be conducive to growing into of cell, and electrostatic spinning rete can be made to be combined better with braiding mesh sheet, this adhesive layer is conducive to promoting growing into fast of cell, makes the amalgamation between compound tissue repairing patch and hyperplastic tissue better.
Accompanying drawing explanation
Fig. 1 is a kind of structural representation of compound tissue repairing patch of the present invention.
Fig. 2 is a kind of structural representation of compound tissue repairing patch of the present invention.
Detailed description of the invention
Below in conjunction with some detailed description of the invention, compound tissue repairing patch of the present invention is described further.Specific embodiment is for further describing the present invention, non-limiting protection scope of the present invention.
Embodiment 1
A preparation method for compound tissue repairing patch, comprises the following steps:
s1.the preparation of electrostatic spinning rete A:
PLA is dissolved in hexafluoroisopropanol solution, the concentration of PLA is 8%(g/ml), obtain uniform macromolecular solution; Loaded by PLA solution in electrostatic spinning syringe, the speed regulating micro-injection pump is 10mL/h, and the voltage regulating high tension generator is 22KV, the receiving range regulating receiving system is 18cm, carry out electrostatic spinning, after reaching thickness 0.3mm, close electrostatic spinning, obtain PLA electrostatic spinning rete.
s2.the preparation of static spinning membrane B:
PCL is dissolved in hexafluoroisopropanol solution, the concentration of PCL is 20%(g/ml), obtain uniform macromolecular solution, loaded by PCL solution in electrostatic spinning syringe, the speed regulating micro-injection pump is 4mL/h, and the voltage regulating high tension generator is 20KV, the receiving range regulating receiving system is 15cm, carry out electrostatic spinning, after reaching thickness 0.15mm, close electrostatic spinning, obtain PCL static spinning membrane.
s3.compound:
S2 gained PCL static spinning membrane is placed in S1 gained PLA electrostatic spinning layer and PP weaves between mesh sheet (thickness 0.1mm), trilamellar membrane is overlaped; The trilamellar membrane folded is put into the hot press that temperature is 75 DEG C, and adjustment pressure is 0.8MPa, carries out hot pressing compound 5min, obtains compound tissue repairing patch.
embodiment 2
A preparation method for compound tissue repairing patch, comprises the following steps:
s1.the preparation of electrostatic spinning rete A:
PLA is dissolved in hexafluoroisopropanol solution, the concentration of PLA is 6%(g/ml), obtain uniform macromolecular solution; Loaded by PLA solution in electrostatic spinning syringe, the speed regulating micro-injection pump is 8mL/h, and the voltage regulating high tension generator is 20KV, the receiving range regulating receiving system is 20cm, carry out electrostatic spinning, after reaching thickness 0.3mm, close electrostatic spinning, obtain PLA electrostatic spinning rete A.
Repeat once, prepare two panels PLA electrostatic spinning rete A altogether.
s2.the preparation of static spinning membrane B:
PCL is dissolved in hexafluoroisopropanol solution, the concentration of PCL is 18%(g/ml), obtain uniform macromolecular solution, loaded by PCL solution in electrostatic spinning syringe, the speed regulating micro-injection pump is 5mL/h, and the voltage regulating high tension generator is 20KV, the receiving range regulating receiving system is 20cm, carry out electrostatic spinning, after reaching thickness 0.15mm, close electrostatic spinning, obtain PCL static spinning membrane B.
Repeat once, prepare two panels PCL static spinning membrane B altogether.
s3.compound:
S2 gained PCL static spinning membrane B is placed in S1 gained PLA electrostatic spinning layer A and PP to weave between mesh sheet (thickness 0.1mm), is followed successively by PLA electrostatic spinning layer A, PCL static spinning membrane B, PP and weaves mesh sheet, PCL static spinning membrane B, PLA electrostatic spinning layer A; Five tunics folded are put into the hot press that temperature is 70 DEG C, and adjustment pressure is 1.0MPa, carries out hot pressing compound 8min, obtains compound tissue repairing patch.
Particularly, the obtained compound tissue repairing patch structure of the present embodiment is as shown in Figure 1: comprise five layers, be followed successively by the first electrostatic spinning rete 1, first adhesive layer 2, mesh grid lamella 3, second adhesive layer 2 and the second electrostatic spinning rete 1, first adhesive layer and the second adhesive layer be the PCL static spinning membrane B that S2 makes, the first electrostatic spinning rete and the second electrostatic spinning rete are the PLA electrostatic spinning rete A that S1 makes.
embodiment 3
A preparation method for compound tissue repairing patch, comprises the following steps:
s1.the preparation of electrostatic spinning rete A:
PLA is dissolved in hexafluoroisopropanol solution, the concentration of PLA is 6%(g/ml), obtain uniform macromolecular solution; Loaded by PLA solution in electrostatic spinning syringe, the speed regulating micro-injection pump is 8mL/h, and the voltage regulating high tension generator is 20KV, the receiving range regulating receiving system is 20cm, carry out electrostatic spinning, after reaching thickness 0.3mm, close electrostatic spinning, obtain PLA electrostatic spinning rete A.
Repeat once, prepare two panels PLA electrostatic spinning rete A altogether.
Wherein a slice PLA electrostatic spinning rete A loads chitosan adherence preventing material.
s2.the preparation of static spinning membrane B:
P4HB is dissolved in chloroformic solution, the concentration of P4HB is 5%(g/ml), obtain uniform macromolecular solution, loaded by P4HB solution in electrostatic spinning syringe, the speed regulating micro-injection pump is 3mL/h, and the voltage regulating high tension generator is 18KV, the receiving range regulating receiving system is 15cm, carry out electrostatic spinning, after reaching thickness 0.15mm, close electrostatic spinning, obtain P4HB static spinning membrane B.
Repeat once, prepare two panels P4HB static spinning membrane B altogether.
s3.compound:
S2 gained P4HB static spinning membrane B is placed in S1 gained PLA electrostatic spinning layer A and PP to weave between mesh sheet (thickness 0.1mm), is followed successively by PLA electrostatic spinning layer A(and loads chitosan adherence preventing material), P4HB static spinning membrane B, PP weave mesh sheet, P4HB static spinning membrane B, PLA electrostatic spinning layer A; Five tunics folded are put into the hot press that temperature is 60 DEG C, and adjustment pressure is 0.8MPa, carries out hot pressing compound 5min, obtains compound tissue repairing patch.
Particularly, the obtained compound tissue repairing patch structure of the present embodiment is as shown in Figure 2: comprise five layers, be followed successively by the first electrostatic spinning rete 11, first adhesive layer 21, mesh grid lamella 3, second adhesive layer 22 and the second electrostatic spinning rete 12, first adhesive layer and the second adhesive layer be the P4HB static spinning membrane B that S2 makes, the first electrostatic spinning rete and the second electrostatic spinning rete are the PLA electrostatic spinning rete A that S1 makes.The outer surface of the first electrostatic spinning tunic 11 is also coated with antiblocking layers 4, and described antiblocking layers is the antiblocking layers be made up of chitosan.
comparative example 1
The PP described in electrostatic spinning rete A and S3 that in embodiment 1, S1 obtains is adopted to weave mesh sheet, this two membranes is overlapping, then the heat pressing process identical with embodiment 1 is adopted directly to carry out hot binding, specifically the two membranes folded is put into the hot press that temperature is 75 DEG C, adjustment pressure is 0.8MPa, carries out hot pressing compound 5min.Result shows, and described electrostatic spinning rete A and PP braiding mesh sheet can not be in conjunction with, the state that both are still separated from each other.
comparative example 2
For in above-mentioned comparative example 1 electrostatic spinning rete A and PP weave mesh sheet can not in conjunction with result, inventor consider may be that hot pressing temperature is lower, be not enough to make described electrostatic spinning rete A hot melt, therefore improve the temperature of hot pressing, extend hot pressing time test.
Specifically hot pressing temperature is 170 DEG C, hot pressing time is 10 minutes, all the other are identical with comparative example 1, not there is hot melt in result electrostatic spinning rete, but PP mesh grid lamella has partial melting, the surface of melt portions and internal structure are completely destroyed, lose the object supported for main mechanical with PP braid.
Above comparative example illustrates, the complex method of conventional direct hot pressing can not make electrostatic spinning rete effectively be combined with braiding mesh sheet, or can destroy the structure of electrostatic spinning rete or braiding mesh sheet, makes to obtain desirable compound film sheet.Electrostatic spinning rete and braiding mesh sheet, by introducing the lower adhesive layer of hot melting temperature, to be combined closely by adhesive layer generation hot melt by the present invention, and remain the structure of electrostatic spinning rete and braiding mesh sheet well; In addition, adhesive layer in the present invention is made by electrostatic spinning, it is compared to existing medical material binding agent, there is three-dimensional porous structure, even if also there is certain hole after hot melt adhesive, be conducive to growing into of cell, make the amalgamation between compound tissue repairing patch and hyperplastic tissue better.
The above embodiment of the present invention is only for example of the present invention is clearly described, and is not the restriction to embodiments of the present invention.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.All any amendments done within the spirit and principles in the present invention, equivalent to replace and improvement etc., within the protection domain that all should be included in the claims in the present invention.
Claims (15)
1. a compound tissue repairing patch, is characterized in that, described compound tissue repairing patch comprises electrostatic spinning rete (1), adhesive layer (2), mesh grid lamella (3); Described electrostatic spinning rete (1) is made up of materials A, and described adhesive layer (2) is made up through electrostatic spinning of material B, and the hot melting temperature of described material B is lower than the hot melting temperature of materials A; Adhesive layer is placed between electrostatic spinning rete and mesh grid lamella, then makes described adhesive layer hot melt by hot pressing, make described electrostatic spinning rete (1) and mesh grid lamella (3) bonding.
2. compound tissue repairing patch according to claim 1, is characterized in that, the fiber interweaving that described electrostatic spinning rete (1) is 10nm ~ 100 μm by diameter forms, and has three-dimensional porous structure.
3. compound tissue repairing patch according to claim 1, it is characterized in that, described materials A is one or more in polylactic acid, PGA or polyvinylidene fluoride.
4. compound tissue repairing patch according to claim 1, is characterized in that, described material B is degradation material polycaprolactone or poly-4 butyric esters.
5. compound tissue repairing patch according to claim 1, is characterized in that, the material of described mesh grid lamella (3) is one or more in polypropylene, polyvinylidene fluoride, polyethylene terephthalate or politef.
6. compound tissue repairing patch according to claim 1, it is characterized in that, described compound tissue repairing patch is made up of the first electrostatic spinning rete, the first adhesive layer, mesh grid lamella, the second adhesive layer, the second electrostatic spinning rete successively.
7. compound tissue repairing patch according to claim 1, it is characterized in that, at least one deck electrostatic spinning layer is for being loaded with the electrostatic spinning layer of medicine.
8. compound tissue repairing patch according to claim 1, it is characterized in that, the outer surface of described electrostatic spinning layer is also coated with anti and/or anticoagulant coatings.
9. the preparation method of compound tissue repairing patch described in claim 1, is characterized in that, comprise the steps:
S1. the static spinning membrane be made up of materials A is prepared;
S2. the static spinning membrane be made up of material B is prepared; S3. be placed on by the static spinning membrane of S2 between the static spinning membrane of S1 and braiding mesh sheet, hot pressing, makes the static spinning membrane hot melt of S2, makes the static spinning membrane of S1 bonding by the static spinning membrane of S2 with mesh grid lamella.
10. the preparation method of compound tissue repairing patch according to claim 9, it is characterized in that, described hot pressing is carried out under the following conditions: temperature is 40 DEG C ~ 90 DEG C, and pressure is 0.4 ~ 1.3MPa, and hot pressing time is 2 ~ 10min.
The preparation method of 11. compound tissue repairing patch according to claim 9, it is characterized in that, the condition of electrostatic spinning described in described step S1, S2 is the speed of micro-injection pump is 0.1 ~ 15.0mL/h, the voltage of high tension generator is 5 ~ 45KV, and the receiving range of receiving system is 5.0 ~ 30.0cm.
The preparation method of 12. compound tissue repairing patch according to claim 9, is characterized in that, be also included in the step loading medicine in the static spinning membrane of S1.
The preparation method of 13. compound tissue repairing patch according to claim 9, it is characterized in that, the top layer being also included in described compound tissue repairing patch arranges the step of anti and/or anticoagulant coatings.
The preparation method of 14. compound tissue repairing patch according to claim 9, is characterized in that, also comprise the steps:
S4., between the static spinning membrane static spinning membrane of S2 being placed on two panels S1, hot pressing, makes the static spinning membrane hot melt of S2, makes the static spinning membrane of two panels S1 bonding; And/or
S5. be placed on by the static spinning membrane of S2 between two panels braiding mesh sheet, hot pressing, makes the static spinning membrane hot melt of S2, makes two panels weave mesh sheet bonding.
Compound tissue repairing patch described in 15. claim 1 to 8 any one repairs the application in reparation goods at the bottom of goods, hernia reparation goods and/or basin at shoulder sleeve.
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| CN105708581B (en) * | 2016-01-21 | 2019-01-11 | 东华大学 | A kind of Static Spinning overlay film type basin with compound bottom sticking patch and preparation method thereof |
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| CN111803710B (en) * | 2016-12-28 | 2022-04-19 | 广州迈普再生医学科技股份有限公司 | Composite tissue repair patch prepared by tape casting process and preparation method thereof |
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Address after: 510663 Guangzhou District, Guangdong, new high tech Industrial Development Zone, Science City, 80 E third district. Applicant after: Guangzhou Maple regenerative medicine Polytron Technologies Inc Address before: 510663 Guangzhou District, Guangdong, new high tech Industrial Development Zone, Science City, 80 E third district. Applicant before: Medprin Regenerative Medical Technologies Co., Ltd. |
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