CN105428199B - Mass spectrometric analysis method and the mass spectrometer with atmospheric pressure interface - Google Patents
Mass spectrometric analysis method and the mass spectrometer with atmospheric pressure interface Download PDFInfo
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- CN105428199B CN105428199B CN201511001447.1A CN201511001447A CN105428199B CN 105428199 B CN105428199 B CN 105428199B CN 201511001447 A CN201511001447 A CN 201511001447A CN 105428199 B CN105428199 B CN 105428199B
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0095—Particular arrangements for generating, introducing or analyzing both positive and negative analyte ions
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0422—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for gaseous samples
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
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Abstract
The invention discloses a kind of mass spectrometric analysis method, including：Receive cation and anion that ion gun discharges；Cation is separated with anion, introduces different ion transfer passages, and be sent into mass analyzer by different ion transfer passages.Another mass spectrometric analysis method provided by the invention, including receive cation, anion and unionization material that ion gun discharges；Cation is separated with anion；And ionization processing is carried out to unionization material, it is then fed into mass analyzer；The cation, anion and unionization material produce under atmospheric pressure.Present invention also offers the mass spectrometer with atmospheric pressure interface based on the above method.
Description
Technical field
The present invention relates to mass spectral analysis field, particularly a kind of mass spectrometric analysis method and the mass spectrum point with atmospheric pressure interface
Analysis apparatus.
Background technology
Mass spectrometric mass analyzer is operated in high vacuum environment, and with various atmospheric pressure environments, ion gun goes out
Now, it is necessary to by caused ion under atmospheric pressure, it is transferred in the mass analyzer in high vacuum environment.For this demand, people
It has developed the atmospheric pressure interface device that ion is transmitted between air and vacuum environment.Atmospheric pressure interface device is arranged on vacuum
One end of cavity, has a small size tunnel (can be aperture or tubule), and the one side of small size tunnel is used towards atmospheric pressure environment
Ion caused by atmospheric pressure ionizationion is come from receiving；Another side is towards vacuum cavity.The diameter of aperture or tubule is typically smaller than
1mm, the air-flow throughput of vacuum cavity is entered for limiting atmospheric environment；Vacuum cavity where aperture, is extracted with vavuum pump
To obtain high vacuum environment, in the vacuum cavity after aperture or tubule, various ion transmission parts are installed successively, such as directly
Flow the ion lens of voltage driving or the multistage bar of alternating voltage driving, installation quality analyzer after ion transmission part.It is foregoing
Atmospheric pressure environment under ion gun after ion is produced, in the presence of electric field and air-flow, enter vacuum chamber from small size tunnel
Body, then focused on and be transferred into mass analyzer by ion transmission part, to realize the mass spectral analysis of ion.Current one
In kind mass spectrograph, vacuum cavity includes 3-4 end to end chamber, and each chamber extracts vacuum with a set of vavuum pump, often
By the aperture or tubule of several millimeters of rank diameters come the amount of limiting air flow through between individual chamber, make the vacuum of each chamber
The difference of the order of magnitude is produced, forms multi-stage vacuum system, ion is so more conducive to and is transferred to high vacuum environment mistake from atmospheric environment
Stability is kept in journey.
The problem of current mass spectrograph with atmospheric pressure interface is present includes：
1st, some atmospheric pressure ionizationions, such as dielectric barrier discharge ion gun etc., can be produced simultaneously under atmospheric pressure environment
Raw cation and anion, under the auxiliary of air-flow, positive and negative ion can enter in mass spectrometric vacuum cavity, but true
Under Altitude, electric field force occupy it is leading, on ion transmission part be adapted to transmission cation voltage, be not appropriate for transmission bear from
Son, therefore only a kind of electropolar ion can enter in mass analyzer.Although it can be changed with pulse on ion transmission part
Voltage, time sharing transmissions positive and negative ion enters mass analyzer, but can so reduce the dutycycle of quality analysis.
2nd, the composition of atmospheric pressure ionizationion output not only contains ion, it is also possible to the neutrality containing a large amount of unionizations point
Son.These neutral molecules are probably the material that the atmospheric pressure ionizationion can ionize, but in ion gun not all from
The neutral molecule left during sonization, it is also possible to it is the material that this kind of atmospheric pressure ionizationion can not ionize, such as electron spray
The low pole material that ion gun can not ionize.The neutral molecule of these unionizations, and the ion that ion gun discharges is together
Vacuum cavity is entered, wherein the ion transmission part that only ion can be electrically driven is transferred in mass analyzer and divided
Analysis, neutral substance are largely discharged by vavuum pump so that also have substantial amounts of material information to fail to carry out mass spectral analysis in sample.
The A of Chinese patent CN 104658848 disclose a kind of spectrometer system, and it contains two ion guns, first from
Component is used to produce cation, and second ion gun is used to produce anion, by two optical systems by first ion gun
Anion caused by caused cation and second ion gun is introduced into the ion trap that can store two kinds of ions simultaneously.This is special
Although profit can analyze positive and negative ion, on condition that positive and negative ion results from two different ion guns independently of each other
In, therefore it can not be analyzed from same ion gun with caused positive and negative ion.
United States Patent (USP) US 11/542,568 discloses a kind of mass spectrograph, is led anion using the first area of an electric field
Enter the first mass analyzer, cation is imported into the second mass analyzer using the second area of electric field.On the one hand, its is positive/negative
Ion is only limited and produced under vacuo, and on the other hand, the patent does not simultaneously include the processing to neutral substance caused by ion gun, then
On the one hand, it needs to use two mass analyzers, increases the complexity of structure.
The content of the invention
It is an object of the present invention to provide a kind of mass spectrometric analysis method and with atmospheric pressure interface mass spectrometer,
Cation and anion that an ion gun is sent can be analyzed simultaneously.
Second object of the present invention is to provide a kind of mass spectrometric analysis method and the mass spectral analysis with atmospheric pressure interface fills
Put, can at least analyze unionization material being discharged by ion gun, being entrained in cation and anion.
It is the cation and anion for discharging same ion gun to realize the design of above-mentioned two technical purpose common technology
Separation.
One side, the present invention provide a kind of mass spectrometric analysis method, including：
Receive cation and anion that ion gun discharges；
Cation is separated with anion, introduces different ion transfer passages, and pass through different ion transfer passages
It is sent into mass analyzer.
In the first mode in the cards, the cation produces under atmospheric pressure with anion.
With reference to the first mode in the cards of one side, in second of mode in the cards, the matter
Spectral analysis method also includes
It is described cation is separated with anion after, the unionization material that the ion gun is discharged carries out ion
Change is handled, and is then fed into mass analyzer；Or
It is described cation is separated with anion before, the unionization material that the ion gun is discharged carries out ion
Change is handled, and then separates cation and anion again.
With reference to second of possible realization side of the first possible implementation and one side of one side
Formula, in the third possible implementation, the unionization material can be ionized under the ion gun, but is failed
All remaining materials during ionization；Or
The unionization material is the material that can not be ionized under the ion gun.
Second aspect, a kind of spectrometer analysis method provided by the invention, including
Receive cation, anion and unionization material that ion gun discharges；
Cation is separated with anion；And
Ionization processing is carried out to unionization material, is then fed into mass analyzer.
In the first mode in the cards, the cation, anion and unionization material produce under atmospheric pressure
It is raw.
With reference to the first possible implementation of one side, in second of possible implementation, it is described not
Ionised species can be ionized under the ion gun, but fail remaining material when whole ionizes；Or
The unionization material is the material that can not be ionized under the ion gun.
Further, in the first aspect in second of mode in the cards, the third mode in the cards, second
In individual aspect, second aspect in the first mode in the cards and second of mode in the cards, to unionization
After material carries out ionization processing, the conveying to ion after ionization processing is carried out under multi-stage vacuum environment.
3rd aspect, the present invention provide a kind of mass spectrometer with atmospheric pressure interface, including apci ion
Source, the atmospheric pressure ionizationion are connected with negative ions separator, and negative ions separator is connected with mass analyzer；
The negative ions separator includes vacuum cavity, includes in vacuum cavity
Cation grabber, cation grabber pass through cation transfer passage quality of connection analyzer；
Anion grabber, anion grabber pass through anion transfer passage quality of connection analyzer.
In the first mode in the cards, in addition to the unionization substance ion source being arranged in vacuum cavity,
Unionization material for being discharged to atmospheric pressure ionizationion carries out ionization processing, unionization substance ion source quality of connection
Analyzer；The unionization substance ion source is arranged on after cation grabber and anion grabber.
In second of mode in the cards, the mass analyzer includes the first mass analyzer and the second mass point
Parser；
Cation transfer passage is connected with the first mass analyzer；
Anion transfer passage is connected with the second mass analyzer.
In the third mode in the cards, the end of the cation transfer passage and anion transfer passage is common
Ion-deflector is connected, is connected by ion-deflector with a mass analyzer.
In the 4th kind of mode in the cards, the mass analyzer is linear ion hydrazine, and cation transfer passage connects
An entrance of linear ion hydrazine is connected to, anion transfer passage is connected to another entrance of linear ion hydrazine.
With reference to the first possible implementation of the 3rd aspect, in second of possible implementation, the matter
Contents analyzer includes the first mass analyzer, the second mass analyzer and the 3rd mass analyzer；
Cation transfer passage is connected with the first mass analyzer；
Anion transfer passage is connected with the second mass analyzer；
Unionization substance ion source is connected with the 3rd mass analyzer.
With reference to the 3rd aspect the first possible implementation, in the third possible implementation, it is described just
The end of ion transfer passage, anion transfer passage and unionization substance ion source connects ion-deflector jointly, leads to
Ion-deflector is crossed to be connected with a mass analyzer.
In the 5th kind of mode in the cards, in addition to the unionization substance ion source being arranged in vacuum cavity,
Unionization material for being discharged to atmospheric pressure ionizationion carries out ionization processing, and unionization substance ion source is arranged on institute
Before stating cation grabber and anion grabber.
With reference to the first mode in the cards of one side, multistage is provided with behind the unionization substance ion source
Vacuum system.
4th aspect, a kind of mass spectrometer with atmospheric pressure interface provided by the invention, including atmospheric pressure from
Component, the atmospheric pressure ionizationion are connected with negative ions separator, and the negative ions separator includes vacuum cavity,
Include cation grabber and anion grabber in vacuum cavity；
Unionization substance ion source is additionally provided with vacuum cavity, for the unionization thing discharged to atmospheric pressure ionizationion
Matter carries out ionization processing, unionization substance ion source quality of connection analyzer；The unionization substance ion source is set
After cation grabber and anion grabber.
Further, multi-stage vacuum system is provided with behind the unionization substance ion source.
For any of present invention mass spectrograph, cation grabber includes the first pole plate with positive electricity, the first pole
Plate is provided with the space passed through for anion, and anion grabber includes the second pole plate with negative electricity, and the second pole plate is provided with
The space passed through for cation.
Mass spectrometric analysis method provided by the invention and the mass spectrometer with atmospheric pressure interface, can be by air ion
The cation and anion that source discharges are separated by negative ions separator, into different ion channels in convey, most
It is sent to eventually in mass analyzer, realizes the cation and anion of one ion gun release of detection simultaneously；And/or to being mixed in
Detected by the unionization material between the cation and anion of ion gun release.
Brief description of the drawings
Fig. 1 is that the structure of one embodiment of the mass spectrometer provided by the present invention with atmospheric pressure interface is shown
It is intended to；
Fig. 2 is that the structure of second embodiment of the mass spectrometer provided by the present invention with atmospheric pressure interface is shown
It is intended to；
Fig. 3 is that the structure of the 3rd embodiment of the mass spectrometer provided by the present invention with atmospheric pressure interface is shown
It is intended to；
Fig. 4 is that the structure of the 4th embodiment of the mass spectrometer provided by the present invention with atmospheric pressure interface is shown
It is intended to；
Fig. 5 is that the structure of the 5th embodiment of the mass spectrometer provided by the present invention with atmospheric pressure interface is shown
It is intended to
Fig. 6 is that the structure of the 6th embodiment of the mass spectrometer provided by the present invention with atmospheric pressure interface is shown
It is intended to；
Fig. 7 is the structural representation that the present invention respectively has the more vacuum systems used in the mass spectrometer of atmospheric pressure interface
Figure.
Embodiment
In order that those skilled in the art more fully understand the present invention program, with reference to the accompanying drawings and detailed description
The present invention is described in further detail.
A kind of mass spectrometric analysis method provided by the invention, be by will in an atmospheric pressure ionizationion with it is caused just from
Son is first introduced into an interface arrangement with anion, and cation is separated with anion in the apparatus, not only can so may be used
With separated processing cation and anion, they are sent into mass analyzer, can make to be mixed in again cation and bear from
Unionization neutral substance in son is separated, to carry out subsequent treatment.
In order to which the cation ion channel different from anion introducing, mass spectrometric analysis method provided by the invention are included：
Receive simultaneously and come from cation and anion caused by atmospheric pressure ionizationion.Described atmospheric pressure ionizationion can be
Electric spray ion source (ESI), atmospheric pressure chemical ion gun (APCI), dielectric barrier discharge ion gun (DBDI), atmospheric pressure are photochemical
Various modifications body when ionization source (APPI) or above several ion guns compound uses is learned, such as combines ESI with APCI
The ESCI compound ion sources designed.
After positive and negative ion is received, it is separated, positive and negative ion is moved towards different directions.In the present invention
In one embodiment of offer, realizing the negative ions separator of above-mentioned function includes vacuum cavity, one end of vacuum cavity
Docked provided with opening, and with atmospheric pressure ionizationion, opening can be aperture, and diameter is typically smaller than 1mm or size is similar
Small pipeline, one end of pipeline stretches into inside cavities, and the other end stretches out cavity and docked with atmospheric pressure ionizationion, using the latter's
Hatch frame is ion by providing transition, can play a part of stabilizing ion motion.It is provided with and carries in vacuum cavity
First pole plate of positive electricity, the first pole plate are provided with the space passed through for anion, and the second pole plate with negative electricity, the second pole
Plate is provided with the space passed through for cation.First pole plate and the second pole plate are in spaced and parallel setting, the sky formed between the two
Between can accommodate the positive and negative ion from atmospheric pressure ionizationion.When positive and negative ion enters between two-plate, the second pole plate attracts
Cation deflects to it, and through its space, similarly the first pole plate attraction anion is to its deflection, through its space.Described sky
Gap can be the pass structure of the circular hole positioned at polar board surface, square hole and other shapes.The edge of these pass structures can be
Closing or marginal belt is had vacant position, the square hole such as set in the middle part of pole plate, two parallel edge is along pole plate
Constantly extension, until passing the edge of pole plate, the gap of one end closing is formd on pole plate.
So far, cation caused by atmospheric pressure ionizationion is separated with anion and come, if in atmospheric pressure ionizationion also
The material of unionization is discharged, because it is neutrality, is not guided by any electromagnetic field, therefore enter in vacuum cavity along it
Fashionable direction motion, i.e., separate with positive and negative ion simultaneously.These unionization materials are probably the atmospheric pressure ionizationion
The material that can be ionized, but in ion gun all ionization when the neutral molecule left, it is also possible to be this
The material that kind atmospheric pressure ionizationion can not ionize, such as the low pole material that electric spray ion source can not ionize.
Embodiment one
As shown in figure 1, the invention provides a kind of specific reality based on above-mentioned principle, method and negative ions separator
Apply mode.
The mass spectrometer with atmospheric pressure interface provided in the present embodiment, including atmospheric pressure ionizationion 100, air
Pressure ion gun 100 is connected with negative ions separator, and negative ions separator includes vacuum cavity 101, vacuum cavity 101
It is interior including cation grabber 102, for capturing cation, anion grabber 105, for capturing anion.Cation is caught
Obtain device 102 and first mass analyzer 104 is connected by cation transfer passage 103；Anion grabber 105 is defeated by anion
Passage 106 is sent to connect the second mass analyzer 107.Cation transfer passage 103 and anion transfer passage 106 can use more
Pole bar, such as quadrupole rod, sextupole bar and ends of the earth bar.Pole bar can be cylinder or hyperboloid.When ion conveys into cation
After passage 103 and anion transfer passage 106, under the electric field that DC voltage (DC) and radio-frequency voltage (RF) are formed, ion is made
Stable oscillation stationary vibration, more stable ion beam is formed after over-focusing, and then conveyed along cation transfer passage 103 or anion
Passage 106 is introduced into corresponding mass analyzer.
In addition, being additionally provided with an ion gun, i.e. unionization substance ion source 108 in vacuum cavity 101, it is set
After cation grabber 102 and anion grabber 105.Unionization substance ion source 108 can to from atmospheric pressure from
Component 100 discharges, and the neutral molecule exported through negative ions separator carries out ionization processing.Unionization material from
Component connects the 3rd mass analyzer 109 by multi-pole plasma transfer passage.Neutral molecule by ionization processing is released
Release ion, after line focus be sent into the 3rd mass analyzer 109 in analyze, it is achieved thereby that in atmospheric pressure ionizationion 100 not
The analysis of ionised species, avoid the missing inspection of a large amount of neutral substances.
In the Transmission system of the mass analyzer 109 of unionization substance ion source 108 to the 3rd, it can set multistage true
Empty set unites (as shown in Figure 7).As sequentially set more than two sub- vacuum chambers.Each vacuum chamber is evacuated to different magnitudes with vavuum pump
Vacuum.Such as the sub- vacuum chamber of the first order 111 can be vacuumized using mechanical pump 110, the second level is true to son further below
Cavity body extracts vacuum using molecule turbine pump 112.This multi-stage vacuum system improves ion and transmitted into the 3rd quality analysis
Stability in device 109.
Unionization substance ion source can be glow discharge ion source, and its advantage is just the of multi-stage vacuum system
It can be discharged under one-level vacuum pressure (about 1Torr or so vacuum), carry out ionization processing, and air can be ionized
The low pole material that pressure ion gun can not ionize；Ultraviolet light photo can also be used from such as in installation UV-light luminous pipe progress
Ionization, is characterized in unrelated with vacuum pressure；EI sources (electron ionization sources), it is characterized in needing higher operated under vacuum,
Vacuum pressure is less than 1E-4Torr, otherwise can burn out filament, is also not necessarily limited to these above-mentioned ion guns, people in the art certainly
Member can be selected according to the enlightenment of the present invention.
First mass analyzer 104, the second mass analyzer 107 and the 3rd mass analyzer 109 can combine actual
Need using known mass analyzer, including multipole rod-type mass analyzer, such as triple quadrupole bar mass analyzer；Also include
Ion strap mass analyzer, such as three-dimensional ion trap and linear ion hydrazine.Inert gas, such as nitrogen can be passed through in an ion trap
Deng ion is further smashed to form daughter ion and analyzed.
Embodiment two
As shown in Fig. 2 present embodiments provide second of mass spectrometer with atmospheric pressure interface.The device and reality
The difference for applying example one is：
First, in the present embodiment, it is inclined to be connected with ion only with a mass analyzer 204, on mass analyzer 204
Turn device 210, cation transfer passage 203, anion transfer passage 206 and unionization substance ion source 208 are both connected to
In described ion-deflector 210.
Second, in the present embodiment, the structure of cation transfer passage 203 and anion transfer passage 206 is divided into three sections
Formula.By taking cation transfer passage 203 as an example, including the first cation transfer passage 31, it is docked with cation grabber.
The end of one cation transfer passage 31 connects the second cation transfer passage 32, and the second cation transfer passage 32 and first is just
Ion transfer passage 31 is vertical, extends (from Fig. 2, i.e., extending along horizontal direction) towards the side of mass analyzer 204,
The end of second cation transfer passage 32 is connected with the 3rd cation transfer passage 33, the 3rd cation transfer passage 33 and
Two cation transfer passages 32 are vertical, and are connected in the ion-deflector 210 of vacuum cavity end.Cation is first
First time yaw motion occurs for the intersection of the cation transfer passage 32 of cation transfer passage 31 and second, into second just from
Sub- transfer passage 32 is transmitted, and is occurred at the second cation transfer passage 32 and the 3rd cation transfer passage 33 second
Deflection, is finally delivered in ion-deflector 210.Anion transfer passage 206 is also conveyed by the first anion being sequentially connected
Passage 61, the second anion transfer passage 62 and the 3rd anion transfer passage 63 are formed, and its connected mode and anion exist
Transmission means therein is identical with cation transfer passage.
When what is discharged in the cation, anion and unionization substance ion source that atmospheric pressure ionizationion discharges
After positive and negative ion is transported in ion-deflector 210, multi beam ion stream, ion-deflector are formed in ion-deflector 210
210 can make these negative ions beams deflect, and transfer out respectively, and then be sent in same mass analyzer 204.
Due to only needing a mass analyzer just can be to cation, the anion of an atmospheric pressure ionizationion release in the present embodiment
Quality analysis is carried out with unionization neutral substance, the structure of mass spectrometer is simplified, has saved space and cost.
Embodiment three
As shown in figure 3, the present embodiment and the difference of embodiment one are, it is logical cation conveying is not included in vacuum cavity
Road and anion transfer passage, the cation and anion separated through negative ions separator, directly impinge upon vacuum cavity
Inwall on, or be used for extract vacuum cavity vacuum pumped.But unionization material is still remained in vacuum cavity
Ion gun 308 and a connected mass analyzer 304.This structure is for only needing to analyze atmospheric pressure ionizationion
The situation design of the neutral substance of release.In such a case it is not necessary to analyze the cation that atmospheric pressure ionizationion discharges
And anion, the effect of negative ions separator are the neutral substance by atmospheric pressure ionizationion release between positive and negative ion
Separate, the neutral substance being sent into vacuum cavity carries out ionization processing by unionization ion gun, is finally sent into quality
In analyzer 304.In the case where that only need to analyze the neutral substance, this structure has structure more compared with embodiment one
Simplify, save space, cost-effective advantage.
Example IV
Fig. 4 is refer to, the present embodiment and the difference of embodiment two are：
Unionization substance ion source is eliminated in vacuum cavity, when the neutrality that need not be discharged to atmospheric pressure ionizationion
When material is detected, this more simplified structure can be used.
Embodiment five
Fig. 5 is refer to, the difference of the present embodiment and example IV is, which further eliminates ion-deflector, and use
As mass analyzer, (detector of linear ion hydrazine 504 is conventional electron multiplier, i.e. Fig. 5 center lines to linear ion hydrazine 504
The circular dash area of property ion trap both sides).The end of 3rd cation transfer passage 533 with one of linear ion hydrazine 504
Entrance connects, and another relative with said inlet with linear ion hydrazine 504 of the end of the 3rd anion transfer passage 633 enters
Mouth connection.Linear ion hydrazine 504 can cause positive and negative ion to enter respectively from relative two entrances, without inclined using ion
Turn device, this structure more simplifies compared with example IV.It should be noted that in the present embodiment, mass analyzer can only
Linear ion hydrazine is used, because only that the entrance that the both ends of linear ion hydrazine can simultaneously as ion, so as to ensure cation
Enter respectively from two ports with anion.
Embodiment six
Negative ions separator is provided with the present embodiment, in vacuum cavity, is additionally provided with unionization substance ion
Source, unlike remaining embodiment, unionization ion gun is arranged on the cation grabber 602 of negative ions separator
Before anion grabber 605.So the various materials of atmospheric pressure ionizationion release are carried out equivalent in vacuum cavity
Secondary ion, then unify to carry out negative ions separation, make it into different ion transfer passages, be finally sent into quality point
In parser.In the present embodiment, cation transfer passage 603, the structure of anion transfer passage 606 and its and mass analyzer
Between annexation it is identical with embodiment five.
It should also be noted that, of the present invention improve in mass spectral analysis, ion is defeated from atmospheric pressure ionizationion
The process of mass analyzer is sent to, for the latter linked detector of mass analyzer, and for analyzing letter caused by detector
Number computer system, techniques known can be used, therefore be no longer described in detail in this patent.
Mass spectrometric analysis method provided by the present invention and the mass spectrometer with air interface have been carried out in detail above
It is thin to introduce.Specific case used herein is set forth to the principle and embodiment of the present invention, and above example is said
It is bright to be only intended to help the core concept for understanding the present invention.It should be pointed out that for those skilled in the art,
Under the premise without departing from the principles of the invention, some improvement and modification can also be carried out to the present invention, these are improved and modification
Fall into the protection domain of the claims in the present invention.
Claims (7)
- A kind of 1. mass spectrometric analysis method, it is characterised in that including：Receive cation and anion that ion gun discharges；Cation and anion are separated, introduce different ion transfer passages, and be sent into by different ion transfer passages In one ion-deflector, it is sent into by the ion-deflector in a mass analyzer；The cation produces under atmospheric pressure with anion.
- 2. mass spectrometric analysis method according to claim 1, it is characterised in that also include：It is described cation is separated with anion after, the unionization material that the ion gun discharges is carried out at ionization Reason, is then fed into mass analyzer；OrIt is described cation is separated with anion before, the unionization material that the ion gun discharges is carried out at ionization Reason, then separates cation and anion again.
- 3. mass spectrometric analysis method according to claim 2, it is characterised in that the unionization material is in the ion Remaining material when can be ionized under source, but fail all to ionize；OrThe unionization material is the material that can not be ionized under the ion gun.
- 4. the mass spectrometric analysis method according to Claims 2 or 3, it is characterised in that ionized to unionization material After processing, the conveying to ion after ionization processing is carried out under multi-stage vacuum environment.
- 5. a kind of mass spectrometer with atmospheric pressure interface, including atmospheric pressure ionizationion, it is characterised in that the atmospheric pressure Ion gun is connected with negative ions separator, and negative ions separator is connected with mass analyzer；The negative ions separator includes vacuum cavity, and cation grabber is included in vacuum cavity and anion captures Device, cation grabber connection cation transfer passage, anion grabber connection anion transfer passage, cation conveying are logical The end of road and anion transfer passage connects ion-deflector jointly, is connected by ion-deflector and a mass analyzer Connect.
- 6. the mass spectrometer according to claim 5 with atmospheric pressure interface, it is characterised in that also include being arranged on Unionization substance ion source in vacuum cavity, the unionization material for being discharged to atmospheric pressure ionizationion ionize Processing, unionization substance ion source quality of connection analyzer；The unionization substance ion source is arranged on cation capture After device and anion grabber.
- 7. the mass spectrometer with atmospheric pressure interface according to claim 5 or 6, the cation grabber includes The first pole plate with positive electricity, the first pole plate are provided with the space passed through for anion, and anion grabber includes carrying negative electricity The second pole plate, the second pole plate is provided with the space passed through for cation.
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| CN105957798A (en) * | 2016-06-08 | 2016-09-21 | 中国科学院合肥物质科学研究院 | Ion trap mass analyzer based infrared light dissociation spectrograph |
| CN106783505B (en) * | 2016-12-30 | 2018-11-20 | 聚光科技(杭州)股份有限公司 | The vacuum interface of atmospheric pressure ionizationion |
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| JPH05251039A (en) * | 1992-03-04 | 1993-09-28 | Ebara Corp | Secondary ion mass spectrometry device |
| DE19844604A1 (en) * | 1998-09-29 | 2000-03-30 | Bernhard Spengler | Transportable laser detection and ionization device for sampling and analyzing particles in a gas flow used for monitoring clean room ventilation exhaust air |
| US7649170B2 (en) * | 2006-10-03 | 2010-01-19 | Academia Sinica | Dual-polarity mass spectrometer |
| US7855361B2 (en) * | 2008-05-30 | 2010-12-21 | Varian, Inc. | Detection of positive and negative ions |
| CN102568997A (en) * | 2011-02-15 | 2012-07-11 | 上海大学 | Bipolar reflection-type flight time mass analyzer |
| CN103681207A (en) * | 2012-09-13 | 2014-03-26 | 中国科学院大连化学物理研究所 | Combined ionization device for ion migration spectrum analysis |
| CN104335323B (en) * | 2013-01-31 | 2017-02-15 | 北京理工大学 | Ion trap-based apparatus and method for analyzing and detecting bipolar ion |
| CN104392887A (en) * | 2014-10-17 | 2015-03-04 | 大连民族学院 | Femtosecond laser post-ionization mass spectrum apparatus |
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