CN105419058B - A kind of disposable vein nutrition infusion bag film and preparation method thereof - Google Patents

A kind of disposable vein nutrition infusion bag film and preparation method thereof Download PDF

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Publication number
CN105419058B
CN105419058B CN201511004098.9A CN201511004098A CN105419058B CN 105419058 B CN105419058 B CN 105419058B CN 201511004098 A CN201511004098 A CN 201511004098A CN 105419058 B CN105419058 B CN 105419058B
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10min
under conditions
infusion bag
density
fusing point
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CN105419058A (en
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王光华
徐小明
金文毅
崔伟
朱素芳
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HUBEI HENGTAI RUBBER CO Ltd
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HUBEI HENGTAI RUBBER CO Ltd
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/04—Homopolymers or copolymers of ethene
    • C08L23/06—Polyethene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/24—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of indefinite length
    • B29C41/32—Making multilayered or multicoloured articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/16—Articles comprising two or more components, e.g. co-extruded layers
    • B29C48/18—Articles comprising two or more components, e.g. co-extruded layers the components being layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C55/00—Shaping by stretching, e.g. drawing through a die; Apparatus therefor
    • B29C55/28—Shaping by stretching, e.g. drawing through a die; Apparatus therefor of blown tubular films, e.g. by inflation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/30—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
    • B32B27/306—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers comprising vinyl acetate or vinyl alcohol (co)polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/34—Layered products comprising a layer of synthetic resin comprising polyamides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/36—Layered products comprising a layer of synthetic resin comprising polyesters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
    • B32B7/04—Interconnection of layers
    • B32B7/10—Interconnection of layers at least one layer having inter-reactive properties
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/04—Homopolymers or copolymers of ethene
    • C08L23/08—Copolymers of ethene
    • C08L23/0807—Copolymers of ethene with unsaturated hydrocarbons only containing more than three carbon atoms
    • C08L23/0815—Copolymers of ethene with aliphatic 1-olefins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2250/00—Layers arrangement
    • B32B2250/24—All layers being polymeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2270/00—Resin or rubber layer containing a blend of at least two different polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/30—Properties of the layers or laminate having particular thermal properties
    • B32B2307/306—Resistant to heat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/50—Properties of the layers or laminate having particular mechanical properties
    • B32B2307/54—Yield strength; Tensile strength
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/71—Resistive to light or to UV
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/724—Permeability to gases, adsorption
    • B32B2307/7242—Non-permeable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2535/00—Medical equipment, e.g. bandage, prostheses, catheter
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00—Properties
    • C08L2201/08—Stabilised against heat, light or radiation or oxydation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/16—Applications used for films
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend

Abstract

The present invention relates to a kind of disposable vein nutrition infusion bag films, including thermal synthesis layer A, structure sheaf B, adhesive layer C and the outer layer D being arranged in order from the inside to the outside, the material of the thermal synthesis layer A is ethylene vinyl acetate (EVA), the structure sheaf B is polyethylene (PE) and the hybrid resin that ethylene octene copolymer (POE) forms, the material of the adhesive layer C is maleic anhydride (MAH) ethene improved octene copolymer (POE), and the outer layer D is the hybrid resin of polyester elastomer (TPEE), nylon (PA) and compatilizer composition.Gamma-ray irradiation sterilizing both may be used with film for the disposable vein nutrition infusion bag; 115~125 DEG C of high-temp steam sterilizings can also be used; in addition, it is not necessary that addition plasticizer, migration precipitation object are few; drug compatibility is excellent; and manufacturing cost is low, and there is higher barrier property, it is good to the protectiveness for the treatment of and nutrition infusion; it reduces drug and rotten probability occurs, ensure the drug safety of patient.

Description

A kind of disposable vein nutrition infusion bag film and preparation method thereof
Technical field
The present invention relates to a kind of medical instrument more particularly to a kind of disposable vein nutrition infusion bag film and its preparation sides Method.
Background technology
At present in disposable vein nutrition infusion bag production field, bag body be divided into polyvinyl chloride (PVC) or its copolymer and Two kinds of materials of ethane-acetic acid ethyenyl ester (EVA).
Polyvinyl chloride (PVC) there are the problem of be mainly：(1) contain polyvinyl chloride monomer in polyvinyl chloride (PVC), it is unfavorable In the health of human body；(2) polyvinyl chloride (PVC) is to change its performance di (2-ethylhexyl) phthalate is added in process of production (DEHP) plasticizer may have the dissolution of di (2-ethylhexyl) phthalate (DEHP) plasticizer, adjacent benzene two during its use Formic acid ethylhexyl (DEHP) is a kind of harmful substance and releasable female hormone, contacts di (2-ethylhexyl) phthalate (DEHP) Development of Reproductive System may be caused bad, seriously endangers health；(3) polyvinyl chloride (PVC) is in process of production To prevent resin from degrading, the stabilizer usually added with elements such as calcic, zinc, barium, these metal ions have in infusion process can It can migrate, enter human body with liquid or blood product, the health of people is affected；(4) polyvinyl chloride (PVC) is to one A little fat-soluble, alcohol-soluble drugs, especially have stronger adsorptivity to antitumor drug, inaccurate so as to cause prescriptions amount Really, curative effect reduces；(5) hydrochloric acid can be formed after polyvinyl chloride (PVC) and its copolymer burning, humans and animals respiratory tract is caused to injure And the erosion to building, it is separately also easy to produce dioxin when burning, far-reaching influence is generated to environment.
Ethane-acetic acid ethyenyl ester (EVA) there are the problem of be mainly：(1) material thermal resistance is bad, and infusion bag is steamed in high temperature Contraction and fold are generated when vapour sterilizes, and are also easily led to drug microbiological contamination and are gone bad and patient's pyrogen reaction；(2) material mechanical performance compared with Difference is only made up by increasing film thickness to improve pull-off force, and usual film thickness is 300~400um, therefore manufacturing cost is significantly Increase.Though manufactured infusion bag intensity can meet national standard, infusion bag intensity is not still high, is easily broken in practical application Phenomena such as damage, leakage；(3) barrier property is low, oxygen transit dose is very big, to treatment and nutrition infusion in infusion process when long Protectiveness is poor, and the drug effect so as to cause drug reduces or even occurs to go bad and cannot use.
Invention content
The purpose of the present invention is being directed to above-mentioned present situation, a kind of disposable vein nutrition infusion bag of excellent combination property is provided It both may be used with film and preparation method thereof the purpose is to improve the more flexible of disposable vein nutrition infusion bag film Gamma-ray irradiation sterilizes, and can also use 115~125 DEG C of high-temp steam sterilizings, and plasticizer need not be added when in addition membrane material is processed Migration precipitation object is few, and drug compatibility is excellent, and mechanical property is strong, and the thin manufacturing cost of thickness is low, and has higher barrier property, right The protectiveness for the treatment of and nutrition infusion is good, reduces drug and rotten probability occurs, ensure the drug safety of patient.
The technical solution adopted by the present invention：A kind of disposable vein nutrition infusion bag film, including arrange successively from the inside to the outside The thermal synthesis layer A of row, structure sheaf B, adhesive layer C and outer layer D, the thermal synthesis layer A material be ethane-acetic acid ethyenyl ester (EVA), The structure sheaf B is polyethylene (PE) and the hybrid resin that ethylene octene copolymer (POE) forms, the material of the adhesive layer C For maleic anhydride (MAH) ethene improved octene copolymer (POE), the outer layer D be polyester elastomer (TPEE), nylon (PA) and The hybrid resin of compatilizer composition.
The present invention effect be：Both gamma-ray irradiation sterilizing may be used, can also have been gone out with 115~125 DEG C of high-temperature steams Bacterium, in addition, it is not necessary that addition plasticizer, migration precipitation object is few, and drug compatibility is excellent, and manufacturing cost is low, and with higher Barrier property, it is good to the protectiveness for the treatment of and nutrition infusion, reduce drug and rotten probability occur, ensure the medication peace of patient Entirely.
Further, in the thermal synthesis layer A, the ethane-acetic acid ethyenyl ester (EVA) is in 190 DEG C, the condition of 2.16kg Under melt flow index be 0.5~5g/10min, vinyl acetate (VA) content be 5~30%.
Further, in the structure sheaf B, the polyethylene (PE) accounts for the 30~80% of the structure sheaf B total weights, Melt flow index under conditions of 190 DEG C, 2.16kg is 0.5~5g/10min, and fusing point is 80~120 DEG C, and density is 0.89~0.92g/cm3, the ethylene octene copolymer (POE) accounts for the 20~70% of the structure sheaf B total weights, 190 DEG C, Melt flow index under conditions of 2.16kg is 0.5~5g/10min, and octene content is 5~45%, and fusing point is 40~100 DEG C, density is 0.85~0.91g/cm3。
Further, in the adhesive layer C, the ethene improved octene copolymer of the maleic anhydride (MAH) (POE) is 190 DEG C, the melt flow index under conditions of 2.16kg be 0.3~5g/10min, 45~95 DEG C of fusing point, maleic anhydride (MAH) contains Amount 0.1~3%, density are 0.85~0.90g/cm3。
Further, in the outer layer D, the polyester elastomer (TPEE) accounts for the outer layer D total weights 45~75%, Melt flow index under conditions of 230 DEG C, 2.16kg is 2~20g/10min, 180~240 DEG C of fusing point, density 1.0 ~1.25g/cm3；Nylon (PA) accounts for the 20~50% of the outer layer D total weights, melt volume under conditions of 275 DEG C, 5kg Flow rate is 50~200cm3/ 10min, fusing point are 170~240 DEG C, and density is 1.0~1.25g/cm3；The compatilizer accounts for The 1~25% of the outer layer D total weights, compatilizer is ethylene-acrylic acid copolymer, Polyolefin Grafted Maleic Anhydride (MAH) is poly- Object or multi-group epoxy compound are closed, melt flow index under conditions of 190 DEG C, 2.16kg is 0.5~10g/ 10min, fusing point are 50~110 DEG C, and density is 0.85~0.97g/cm3。
Further, the overall thickness of the disposable vein nutrition infusion bag film is 150~250um, wherein the heat The thickness proportion for closing layer A is 10~20%, and the thickness proportion of the structure sheaf B is 50~80%, the thickness ratio of the adhesive layer C Example is 5~15%, and the thickness proportion of the outer layer D is 5~20%.
The technical solution adopted by the present invention：A kind of preparation method of disposable vein nutrition infusion bag film, including it is following Step：S1：Polyethylene (PE) and ethylene octene copolymer (POE) are first mixed to form the first mixture, wherein the polyethylene (PE) the 30~80% of first total weight of the mixture are accounted for；Meanwhile by polyester elastomer (TPEE), nylon (PA) and compatilizer It is mixed to form the second mixture, wherein the polyester elastomer (TPEE) accounts for second total weight of the mixture 45~75%, Buddhist nun Imperial (PA) accounts for the 20~50% of second total weight of the mixture, the compatilizer account for second total weight of the mixture 1~ 25%； S2：Ethane-acetic acid ethyenyl ester (EVA) and maleic anhydride (MAH) ethene improved octene copolymer (POE) is provided, successively With more suction feeders respectively by the ethane-acetic acid ethyenyl ester (EVA), first mixture, the maleic anhydride (MAH) ethene improved octene copolymer (POE) and second mixture suck in more extruder hoppers；S3：Using co-extrusion Blown film or casting technique are produced to obtain film, this film is configured to the ethane-acetic acid ethyenyl ester (EVA) and forms thermal synthesis layer A, first mixture form structure sheaf B, and the ethene improved octene copolymer of the maleic anhydride (MAH) (POE) forms bonding Layer C, second mixture forms outer layer D, and the thermal synthesis layer A, structure sheaf B, adhesive layer C and outer layer D are arranged in order； S4：By the film be placed in Co60 radiation chamber or electron ray room in carry out crosslinking with radiation, and dose of radiation is 5~15Mrad, Gel content is 35~65%, to form disposable vein nutrition infusion bag film.
The present invention effect be：Both gamma-ray irradiation sterilizing may be used, can also have been gone out with 115~125 DEG C of high-temperature steams Bacterium, in addition, it is not necessary that addition plasticizer, migration precipitation object is few, and drug compatibility is excellent, and manufacturing cost is low, and with higher Barrier property, it is good to the protectiveness for the treatment of and nutrition infusion, reduce drug and rotten probability occur, ensure the medication peace of patient Entirely.
Further, melt flow index of the ethane-acetic acid ethyenyl ester (EVA) under conditions of 190 DEG C, 2.16kg For 0.5~5g/10min, vinyl acetate (VA) content is 5~30%；The polyethylene (PE) is in 190 DEG C, the item of 2.16kg Melt flow index under part is 0.5~5g/10min, and fusing point is 80~120 DEG C, and density is 0.89~0.92g/cm3, described Melt flow index of the ethylene octene copolymer (POE) under conditions of 190 DEG C, 2.16kg is 0.5~5g/10min, octene Content is 5~45%, and fusing point is 40~100 DEG C, and density is 0.85~0.91g/cm3；The maleic anhydride (MAH) is modified second Melt flow index of the alkene octene copolymer (POE) under conditions of 190 DEG C, 2.16kg is 0.3~5g/10min, fusing point 45 ~95 DEG C, maleic anhydride (MAH) content 0.1~3%, density is 0.85~0.90g/cm3；The polyester elastomer (TPEE) Melt flow index under conditions of 230 DEG C, 2.16kg is 2~20g/10min, 180~240 DEG C of fusing point, density is 1.0~ 1.25g/cm3；Melt volume-flow rate of the nylon (PA) under conditions of 275 DEG C, 5kg is 50~200cm3/ 10min, Fusing point is 170~240 DEG C, and density is 1.0~1.25g/cm3；The compatilizer is ethylene-acrylic acid copolymer, polyolefin connects Branch maleic anhydride (MAH) polymer or multi-group epoxy compound, melt flows under conditions of 190 DEG C, 2.16kg refer to Number is 0.5~10g/10min, and fusing point is 50~110 DEG C, and density is 0.85~0.97g/cm3。
Further, the overall thickness of the disposable vein nutrition infusion bag film of the formation is 150~250um, wherein The thickness proportion of the thermal synthesis layer A is 10~20%, and the thickness proportion of the structure sheaf B is 50~80%, the adhesive layer C Thickness proportion be 5~15%, the thickness proportion of the outer layer D is 5~20%.
Further, the production district that described step S1, S2, S3 and S4 are C grades in clean rank carries out, and the blown film is cold But mode uses up-draught cold or downward-blowing water-cooling technique, and the air cleaning rank in film bubble is A grades.
Description of the drawings
Fig. 1 show the structural schematic diagram of disposable vein nutrition infusion bag film provided by the invention.
Fig. 2, which show the step of preparation method of secondary property nutrition transfusion bag film provided by the invention, to scheme.
Specific implementation mode
The principle and features of the present invention will be described below with reference to the accompanying drawings, and the given examples are served only to explain the present invention, and It is non-to be used to limit the scope of the present invention.
As shown in Figure 1, be a kind of disposable vein nutrition infusion bag film provided by the invention comprising from the inside to the outside according to Thermal synthesis layer A, structure sheaf B, adhesive layer C and the outer layer D of secondary arrangement.The material of thermal synthesis layer A is ethane-acetic acid ethyenyl ester (EVA), Structure sheaf B is polyethylene (PE) and the hybrid resin that ethylene octene copolymer (POE) forms, and the material of adhesive layer C is maleic acid Acid anhydride (MAH) ethene improved octene copolymer (POE), outer layer D are polyester elastomer (TPEE), nylon (PA) and compatilizer composition Hybrid resin.
In thermal synthesis layer A, melt flow index of the ethane-acetic acid ethyenyl ester (EVA) under conditions of 190 DEG C, 2.16kg is 0.5~5g/10min, vinyl acetate (VA) content are 5~30%.
Preferably, melt flow index of the ethane-acetic acid ethyenyl ester (EVA) under conditions of 190 DEG C, 2.16kg be 1~ 3g/10min, vinyl acetate (VA) content 8~25%.
In structure sheaf B, polyethylene (PE) accounts for the 30~80% of structure sheaf B total weights, under conditions of 190 DEG C, 2.16kg Melt flow index be 0.5~5g/10min, fusing point be 80~120 DEG C, density be 0.89~0.92g/cm3, ethylene octene Copolymer (POE) accounts for the 20~70% of structure sheaf B total weights, and melt flow index under conditions of 190 DEG C, 2.16kg is 0.5~5g/10min, octene content are 5~45%, and fusing point is 40~100 DEG C, and density is 0.85~0.91g/cm3。
Preferably, polyethylene (PE) accounts for the 50~70% of structure sheaf B total weights, under conditions of 190 DEG C, 2.16kg Melt flow index is 1~3g/10min, and fusing point is 90~115 DEG C, and density is 0.9~0.91g/cm3, ethylene octene copolymerization Object (POE) accounts for the 30~50% of structure sheaf B total weights, melt flow index under conditions of 190 DEG C, 2.16kg be 1~ 3g/10min, octene content are 15~35%, and fusing point is 55~90 DEG C, and density is 0.86~0.89g/cm3。
In adhesive layer C, maleic anhydride (MAH) ethene improved octene copolymer (POE) is under conditions of 190 DEG C, 2.16kg Melt flow index be 0.3~5g/10min, 45~95 DEG C of fusing point, maleic anhydride (MAH) content 0.1~3%, density is 0.85~0.90g/cm3。
Preferably, maleic anhydride (MAH) ethene improved octene copolymer (POE) is 190 DEG C, the 2.16kg under conditions of Melt flow index is 1~4g/10min, and 50~75 DEG C of fusing point, maleic anhydride (MAH) content 0.3~1.5%, density is 0.86~0.88g/cm3。
In outer layer D, polyester elastomer (TPEE) accounts for the 45~75% of outer layer D total weights, in 230 DEG C, the condition of 2.16kg Under melt flow index be 2~20g/10min, fusing point be 180~240 DEG C, density be 1.0~1.25g/cm3；Nylon (PA) the 20~50% of outer layer D total weights are accounted for, melt volume-flow rate under conditions of 275 DEG C, 5kg be 50~ 200cm3/ 10min, fusing point are 170~240 DEG C, and density is 1.0~1.25g/cm3；Compatilizer account for outer layer D total weights 1~ 25%, compatilizer is ethylene-acrylic acid copolymer, Polyolefin Grafted Maleic Anhydride (MAH) polymer or multifunction group epoxy Object is closed, melt flow index under conditions of 190 DEG C, 2.16kg is 0.5~10g/10min, and fusing point is 50~110 DEG C, close Degree is 0.85~0.97g/cm3。
Preferably, polyester elastomer (TPEE) accounts for the 55~70% of outer layer D total weights, in 230 DEG C, the condition of 2.16kg Under melt flow index be 3~15g/10min, fusing point be 190~220 DEG C, density be 1.1~1.2g/cm3；Nylon (PA) The 25~45% of outer layer D total weights are accounted for, melt volume-flow rate under conditions of 275 DEG C, 5kg is 75~150cm3/ 10min, fusing point are 185~215 DEG C, and density is 1.05~1.2g/cm3；Compatilizer accounts for the 3~15% of outer layer D total weights, phase Appearance agent is ethylene-acrylic acid copolymer, and melt flow index under conditions of 190 DEG C, 2.16kg is 1~8g/10min, is melted Point is 55~90 DEG C, and density is 0.86~0.95g/cm3。
The overall thickness of the disposable vein nutrition infusion bag film is 150~250um, the wherein thickness proportion of thermal synthesis layer A It is 10~20%, the thickness proportion of structure sheaf B is 50~80%, and the thickness proportion of adhesive layer C is 5~15%, the thickness of outer layer D Degree ratio is 5~20%.
In this way, a kind of disposable vein nutrition infusion bag film provided by the invention, has the following advantages：
1. raw material does not use polyvinyl chloride (PVC) or its copolymer, so not containing polyvinyl chloride monomer and neighbour in membrane material Phthalic acid ethylhexyl (DEHP) plasticizer, the potential hazard for avoiding the two from generating human body；
2. raw material composition is all inert medical macromolecular materials and is not susceptible to react with drug, migration precipitation object is few, And absorption will not be generated to drug and lessened the curative effect.It is very convenient using rear recycling, if not will produce when burning disposal Dioxin, impacts environment minimum, reaches Packaging Reduce, energy-saving purpose, belongs to environment-friendly products.
3. being used as thermal synthesis layer, the high polyester elastomer of fusing point using low-melting ethane-acetic acid ethyenyl ester (EVA) (TPEE), the hybrid resin of nylon (PA) and compatilizer composition both can also use high warm as outer layer with high-frequency welding Pressure quickly heat-sealing.
4. structure sheaf is made of the hybrid resin that medical grade polyvinyl (PE) and ethylene octene copolymer (POE) form, material The mechanical properties such as tensile strength, pull-off force and the tearing strength of material are far more than polyvinyl chloride (PVC) or its copolymer and ethylene- Vinyl acetate (EVA), membrane material thickness is thin, and manufacturing cost is low.
5. barrier property is high, oxygen transit dose is small, good to the protectiveness for the treatment of and nutrition infusion in infusion process when long, It reduces drug and rotten probability occurs, ensure the drug safety of patient.
6. being solved pure as outer layer using the hybrid resin of polyester elastomer (TPEE), nylon (PA) and compatilizer composition Nylon (PA) occurs the browning of membrane material surface in γ ray sterilization, leachable increases and curling problem, hybrid resin curling resistance Can be good, unsymmetric structure will not crimp, to keep bag making welding very smooth.
As shown in Fig. 2, be a kind of preparation method of disposable vein nutrition infusion bag film provided by the invention, including with Lower step：
S1：Polyethylene (PE) and ethylene octene copolymer (POE) are first mixed to form the first mixture, wherein the poly- second Alkene (PE) accounts for the 30~80% of first total weight of the mixture；Meanwhile by polyester elastomer (TPEE), nylon (PA) and compatible Agent is mixed to form the second mixture, wherein the polyester elastomer (TPEE) accounts for second total weight of the mixture 45~75%, Nylon (PA) accounts for the 20~50% of second total weight of the mixture, and the compatilizer accounts for the 1 of second total weight of the mixture ~25%.
Specifically, melt flow index of the polyethylene (PE) under conditions of 190 DEG C, 2.16kg is 0.5~5g/ 10min, fusing point are 80~120 DEG C, and density is 0.89~0.92g/cm3, the ethylene octene copolymer (POE) 190 DEG C, Melt flow index under conditions of 2.16kg is 0.5~5g/10min, and octene content is 5~45%, and fusing point is 40~100 DEG C, density is 0.85~0.91g/cm3；Melt flows of the polyester elastomer (TPEE) under conditions of 230 DEG C, 2.16kg Index is 2~20g/10min, and 180~240 DEG C of fusing point, density is 1.0~1.25g/cm3；The nylon (PA) 275 DEG C, Melt volume-flow rate under conditions of 5kg is 50~200cm3/ 10min, fusing point be 170~240 DEG C, density be 1.0~ 1.25g/cm3；The compatilizer is ethylene-acrylic acid copolymer, Polyolefin Grafted Maleic Anhydride (MAH) polymer or multifunctional Group's epoxide, melt flow index under conditions of 190 DEG C, 2.16kg are 0.5~10g/10min, fusing point is 50~ 110 DEG C, density is 0.85~0.97g/cm3。
Preferably, polyethylene (PE) accounts for the 50~70% of first total weight of the mixture, in 190 DEG C, the item of 2.16kg Melt flow index under part is 1~3g/10min, and fusing point is 90~115 DEG C, and density is 0.9~0.91g/cm3, ethylene is pungent Alkene copolymer (POE) accounts for the 30~50% of first total weight of the mixture, melt flow under conditions of 190 DEG C, 2.16kg Dynamic index is 1~3g/10min, and octene content is 15~35%, and fusing point is 55~90 DEG C, and density is 0.86~0.89g/cm3； Polyester elastomer (TPEE) accounts for second total weight of the mixture 55~70%, melt flow under conditions of 230 DEG C, 2.16kg Dynamic index is 3~15g/10min, and 190~220 DEG C of fusing point, density is 1.1~1.2g/cm3；It is mixed that nylon (PA) accounts for described second The 25~45% of object total weight are closed, melt volume-flow rate under conditions of 275 DEG C, 5kg is 75~150cm3/ 10min, fusing point are 185~215 DEG C, and density is 1.05~1.2g/cm3；Compatilizer account for second total weight of the mixture 3~ 15%, compatilizer is ethylene-acrylic acid copolymer, and melt flow index under conditions of 190 DEG C, 2.16kg is 1~8g/ 10min, fusing point are 55~90 DEG C, and density is 0.86~0.95g/cm3。
In addition, the first mixture and the second mixture are individually placed to be stirred mixing in batch mixer, and its mixing time For 3~6min, preferably 4~5min.
S2：Ethane-acetic acid ethyenyl ester (EVA) and maleic anhydride (MAH) ethene improved octene copolymer (POE) is provided, according to It is secondary with more suction feeders respectively by the ethane-acetic acid ethyenyl ester (EVA), first mixture, the maleic anhydride (MAH) ethene improved octene copolymer (POE) and second mixture suck in more extruder hoppers.
Specifically, melt flow index of the ethane-acetic acid ethyenyl ester (EVA) under conditions of 190 DEG C, 2.16kg is 0.5~5g/10min, vinyl acetate (VA) content are 5~30%；The ethene improved octene copolymer of the maleic anhydride (MAH) Melt flow index of the object (POE) under conditions of 190 DEG C, 2.16kg is 0.3~5g/10min, 45~95 DEG C of fusing point, Malaysia Acid anhydrides (MAH) content 0.1~3%, density are 0.85~0.90g/cm3。
Preferably, melt flow index of the ethane-acetic acid ethyenyl ester (EVA) under conditions of 190 DEG C, 2.16kg be 1~ 3g/10min, vinyl acetate (VA) content 8~25%；Maleic anhydride (MAH) ethene improved octene copolymer (POE) is 190 DEG C, the melt flow index under conditions of 2.16kg be 1~4g/10min, 50~75 DEG C of fusing point, maleic anhydride (MAH) content 0.3~1.5%, density is 0.86~0.88g/cm3。
In addition, using automatic suction system of weighing, such each raw material when being sucked to each raw material using suction feeder What is be inhaled into and squeeze out measures control, and then can control each finally formed thickness of layer raw material.
S3：It is produced using coextrusion film blowing or casting technique to obtain film, this film is configured to the ethylene-acetic acid Vinyl acetate (EVA) forms thermal synthesis layer A, and first mixture forms structure sheaf B, and the maleic anhydride (MAH) is ethene improved pungent Alkene copolymer (POE) forms adhesive layer C, and second mixture forms outer layer D, and the thermal synthesis layer A, structure sheaf B, adhesive layer C and outer layer D are arranged in order.
Specifically, the blown film type of cooling can be that up-draught is cold and downward-blowing water-cooling, it is preferable that in such a way that up-draught is cold.
S4：By the film be placed in Co60 radiation chamber or electron ray room in carry out crosslinking with radiation, and dose of radiation be 5~ 15Mrad, gel content is 35~65%, to form the disposable vein nutrition infusion bag film.
Preferably, the film is placed in high energy electron ray room and carries out crosslinking with radiation, and dose of radiation be 6~ 12Mrad, gel content are 40~55%.
As a result of automatic suction system of weighing so that the amount that each raw material is inhaled into and squeezes out is under control, in turn Each finally formed thickness of layer raw material can be controlled.Therefore, finally formed disposable vein nutrition infusion bag film Overall thickness is 150~250um, wherein the thickness proportion of the thermal synthesis layer A is 10~20%, the thickness proportion of the structure sheaf B It is 50~80%, the thickness proportion of the adhesive layer C is 5~15%, and the thickness proportion of the outer layer D is 5~20%.
The disposable vein nutrition infusion bag film can be two layered cylinder film, double-layer tablets film and single-layer sheet film, preferably bilayer Cylinder film.
In addition, the production district that above-mentioned steps S1, S2, S3 and S4 are C grades in clean rank carries out, the blown film type of cooling can For up-draught is cold and downward-blowing water-cooling, and the air cleaning rank in film bubble is A grades.
A kind of preparation method of disposable vein nutrition infusion bag film provided by the invention, has the following advantages：
1. raw material does not use polyvinyl chloride (PVC) or its copolymer, so not containing polyvinyl chloride monomer and neighbour in membrane material Phthalic acid ethylhexyl (DEHP) plasticizer, the potential hazard for avoiding the two from generating human body；
2. improving heat resistance using crosslinking with radiation technical finesse product, sterilising temp is not likely to produce change up to 125 DEG C Shape, it is ensured that sterility requirements (F0＞ 12), solve polyvinyl chloride (PVC) or its copolymer and ethylene-vinyl acetate (EVA) two Kind not above 110 DEG C problems of material sterilising temp, greatly improve the Sterility Assurance value of nutrition infusion bag, while can also resistance to y Ray sterilizing.
3. raw material composition is all inert medical macromolecular materials and is not susceptible to react with drug, migration precipitation object is few, And absorption will not be generated to drug and lessened the curative effect.It is very convenient using rear recycling, if not will produce when burning disposal Dioxin, impacts environment minimum, reaches Packaging Reduce, energy-saving purpose, belongs to environment-friendly products.
4. being used as thermal synthesis layer, the high polyester elastomer of fusing point using low-melting ethane-acetic acid ethyenyl ester (EVA) (TPEE), the hybrid resin of nylon (PA) and compatilizer composition both can also use high warm as outer layer with high-frequency welding Pressure quickly heat-sealing.
5. structure sheaf is made of the hybrid resin that medical grade polyvinyl (PE) and ethylene octene copolymer (POE) form, material The mechanical properties such as tensile strength, pull-off force and the tearing strength of material are far more than polyvinyl chloride (PVC) or its copolymer and ethylene- Vinyl acetate (EVA), membrane material thickness is thin, and manufacturing cost is low.
6. barrier property is high, oxygen transit dose is small, good to the protectiveness for the treatment of and nutrition infusion in infusion process when long, It reduces drug and rotten probability occurs, ensure the drug safety of patient.
7. the production process of film from raw pellets to film, crosslinking with radiation carried out in clean environment, avoid particle and Other pollutions, ensure that the sanitation performance of product to greatest extent.
8. being solved pure as outer layer using the hybrid resin of polyester elastomer (TPEE), nylon (PA) and compatilizer composition Nylon (PA) occurs the browning of membrane material surface in γ ray sterilization, leachable increases and curling problem, hybrid resin curling resistance Can be good, unsymmetric structure will not crimp, to keep bag making welding very smooth.
Specific implementation situation is shown in Table 1.
Respectively situation is embodied in formula to table 1
Reference《National Medical Packing Materials calibrating gas transit dose measuring method》(YBB00082003) oxygen of the various embodiments described above is examined Gas transit dose and nitrogen transit dose, while polyvinyl chloride (PVC) film and ethane-acetic acid ethyenyl ester (EVA) film are tested, it examines It tests Comparative result and is shown in Table 2.
2 gas transit dose survey report of table [cm3/ (m224h0.1MPa)]
From above-mentioned table 2 it can be found that the gas transit dose of each embodiment is relatively small, compared with PVC and EVA film when long It is more preferable to the protectiveness for the treatment of and nutrition infusion in infusion process, it reduces drug and rotten probability occurs, ensure the medication of patient Safety.
According to《Currency of Chinese medical industry standard》Disposable nutrition transfusion bag (YY0611-2007),《National pack Material standard》Multilayer co-squeeze film for transfusion, bag general rule (YBB00342002) are tested, and the various embodiments described above product physics is examined Performance, wherein 1 inspection result of embodiment are shown in Table 3.
3 physical property survey report of table
According to 88 ＞ of United States Pharmacopeia USP35 ＜,《National Medical Packing Materials standard》YBB00012003, YBB00032003 and YBB00052003 tests, and the various embodiments described above product bio-safety performance, wherein 2 inspection result of embodiment is examined to be shown in Table 4。
4 bio-safety performance survey report of table
According to《Currency of Chinese medical industry standard》Disposable nutrition transfusion bag (YY0611-2007) and United States Pharmacopeia 87 ＞ of USP35 ＜ test, and the various embodiments described above product chemical property, wherein 3 inspection result of embodiment is examined to be shown in Table 5.
5 chemical property survey report of table
The rich former medicine company inaction pharmaceutical factory in this product commission Anhui has carried out drug compatibility experiment, is tested below for embodiment 4 Conclusion.According to《Pharmacopoeia of People's Republic of China》The two annex XIXC medicine stability tests guidelines of version in 2010 and《Medicine Product packaging material and drug compatibility test direction principle》(YBB00142002) requirement in by exposure experiments to light, accelerates to try Test, long-term test results show using a variety of drugs of disposable vein nutrition infusion bag film bag-making loading provided by the invention, It places under difficult environmental conditions, every Testing index is without significant change and meets regulation, it was demonstrated that disposable vein nutrition is defeated Liquid bag film does not occur physics, chemistry, biology with drug and reacts, and stable quality does not influence the original characteristic of drug, meet drug Compatibility test requirement, specific test result are shown in Table 6~table 9.
6 nutrition infusion bag of table is reported with hydrochloric acid lomefloxacin injection compatibility test
7 nutrition infusion bag of table is reported with Dextrose and Sodium Chloride Inj. compatibility test
8 nutrition infusion bag of table is reported with fat emulsion injection compatibility test
9 nutrition infusion bag of table is reported with Amino Acid Compound Injection (3AA) compatibility test
Drug absorbability and stability test have been carried out, has injected corresponding infusion bag after drawing drug with disposable syringe respectively In, drug needs 30 mixings of shake well after infusion bag is added, and places at different ambient temperatures, respectively at 0,8,24,48h Inspection by sampling.Vapor recovery unit is not good substantially to taxol, insulin for EVA and 5 film of embodiment, and changes of contents is small, PVC film pair Two kinds of drugs have certain absorption, and changes of contents is big, and when use must shorten the time of instiling, and otherwise influence drug effect.Embodiment 5, EVA and PVC film specific test result are shown in Table 10~table 11.
10 content of taxol of table changes survey report [%]
11 insulin content of table changes survey report [mU/L]
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all the present invention spirit and Within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.

Claims (8)

1. a kind of disposable vein nutrition infusion bag film, which is characterized in that including be arranged in order from the inside to the outside thermal synthesis layer A, The material of structure sheaf B, adhesive layer C and outer layer D, the thermal synthesis layer A are EVA, and the structure sheaf B is polyethylene（PE）And ethylene Octene copolymer（POE）The material of the hybrid resin of composition, the adhesive layer C is maleic anhydride（MAH）Ethene improved octene is total Polymers（POE）, the outer layer D is polyester elastomer（TPEE）, nylon（PA）With the hybrid resin of compatilizer composition；The heat seal In layer A, melt flow indexes of EVA under conditions of 190 DEG C, 2.16kg is 0.5~5g/10min, vinyl acetate （VA）Content is 5~30%；In the structure sheaf B, the polyethylene（PE）The 30~80% of the structure sheaf B total weights are accounted for, 190 DEG C, the melt flow index under conditions of 2.16kg be 0.5~5g/10min, fusing point is 80~120 DEG C, density 0.89 ~0.92g/cm3, the ethylene octene copolymer（POE）Account for the 20~70% of the structure sheaf B total weights, 190 DEG C, Melt flow index under conditions of 2.16kg is 0.5~5g/10min, and octene content is 5~42%, and fusing point is 40~90 DEG C, Density is 0.85~0.87g/cm3。
2. disposable vein nutrition infusion bag film as described in claim 1, it is characterised in that：It is described in the adhesive layer C Maleic anhydride（MAH）Ethene improved octene copolymer（POE）Melt flow index under conditions of 190 DEG C, 2.16kg is 0.3 ~5g/10min, 45~95 DEG C of fusing point, maleic anhydride（MAH）Content 0.1~3%, density are 0.85~0.90g/cm3。
3. disposable vein nutrition infusion bag film as described in claim 1, it is characterised in that：It is described poly- in the outer layer D Ester elastomer（TPEE）The outer layer D total weights 45~75% are accounted for, melt flow index under conditions of 230 DEG C, 2.16kg is 2~20g/10min, 180~240 DEG C of fusing point, density are 1.0~1.25g/cm3；Nylon（PA）Account for the outer layer D total weights 20~50%, melt volume-flow rate under conditions of 275 DEG C, 5kg is 50~200cm3/ 10min, fusing point be 170~ 240 DEG C, density is 1.0~1.25g/cm3；The compatilizer accounts for the 1~25% of the outer layer D total weights, and compatilizer is ethylene- Acrylic copolymer, Polyolefin Grafted Maleic Anhydride polymer or multi-group epoxy compound, in 190 DEG C, the item of 2.16kg Melt flow index under part is 0.5~10g/10min, and fusing point is 50~110 DEG C, and density is 0.85~0.97g/cm3。
4. disposable vein nutrition infusion bag film as described in claim 1, it is characterised in that：The disposable vein nutrition The overall thickness of film for infusion bag is 150~250um, wherein the thickness proportion of the thermal synthesis layer A is 10~20%, the structure sheaf B Thickness proportion be 50~80%, the thickness proportion of the adhesive layer C is 5~15%, the thickness proportion of the outer layer D is 5~ 20%。
5. a kind of preparation method of any disposable vein nutrition infusion bag film of claim 1 ~ 4, it is characterised in that： Include the following steps：
S1：First by polyethylene（PE）And ethylene octene copolymer（POE）It is mixed to form the first mixture, wherein the polyethylene （PE）Account for the 30~80% of first total weight of the mixture；Meanwhile by polyester elastomer（TPEE）, nylon（PA）And compatilizer It is mixed to form the second mixture, wherein the polyester elastomer（TPEE）Account for second total weight of the mixture 45~75%, nylon （PA）The 20~50% of second total weight of the mixture are accounted for, the compatilizer accounts for the 1~25% of second total weight of the mixture；
S2：EVA and maleic anhydride are provided（MAH）Ethene improved octene copolymer（POE）, distinguished successively with more suction feeders By the EVA, first mixture, the maleic anhydride（MAH）Ethene improved octene copolymer（POE）It is mixed with described second Object is closed to suck in more extruder hoppers；
S3：It being produced using coextrusion film blowing or casting technique to obtain film, this film is configured to the EVA and forms thermal synthesis layer A, First mixture forms structure sheaf B, the maleic anhydride（MAH）Ethene improved octene copolymer（POE）Form adhesive layer C, second mixture forms outer layer D, and the thermal synthesis layer A, structure sheaf B, adhesive layer C and outer layer D are arranged in order；
S4：By the film be placed in Co60 radiation chamber or electron ray room in carry out crosslinking with radiation, and dose of radiation be 5~ 15Mrad, gel content is 35~65%, to form disposable vein nutrition infusion bag film.
6. the preparation method of disposable vein nutrition infusion bag film as claimed in claim 5, it is characterised in that：The EVA Melt flow index under conditions of 190 DEG C, 2.16kg is 0.5~5g/10min, vinyl acetate（VA）Content be 5~ 30%；The polyethylene（PE）Melt flow index under conditions of 190 DEG C, 2.16kg is 0.5~5g/10min, and fusing point is 80~120 DEG C, density is 0.89~0.92g/cm3, the ethylene octene copolymer（POE）Under conditions of 190 DEG C, 2.16kg Melt flow index be 0.5~5g/10min, octene content be 5~45%, fusing point be 40~100 DEG C, density be 0.85~ 0.91g/cm3；The maleic anhydride（MAH）Ethene improved octene copolymer（POE）It is molten under conditions of 190 DEG C, 2.16kg Body flow index is 0.3~5g/10min, 45~95 DEG C of fusing point, maleic anhydride（MAH）Content 0.1~3%, density be 0.85~ 0.90g/cm3；The polyester elastomer（TPEE）Melt flow index under conditions of 230 DEG C, 2.16kg is 2~20g/ 10min, 180~240 DEG C of fusing point, density are 1.0~1.25g/cm3；The nylon（PA）It is molten under conditions of 275 DEG C, 5kg Body rate of volume flow is 50~200cm3/ 10min, fusing point are 170~240 DEG C, and density is 1.0~1.25g/cm3；The phase Appearance agent be ethylene-acrylic acid copolymer, Polyolefin Grafted Maleic Anhydride polymer or multi-group epoxy compound, 190 DEG C, Melt flow index under conditions of 2.16kg is 0.5~10g/10min, and fusing point is 50~110 DEG C, density is 0.85~ 0.97g/cm3。
7. the preparation method of disposable vein nutrition infusion bag film as claimed in claim 5, it is characterised in that：The formation Disposable vein nutrition infusion bag film overall thickness be 150~250um, wherein the thickness proportion of the thermal synthesis layer A be 10 The thickness proportion of~20%, the structure sheaf B are 50~80%, and the thickness proportion of the adhesive layer C is 5~15%, the outer layer D Thickness proportion be 5~20%.
8. the preparation method of disposable vein nutrition infusion bag film as claimed in claim 5, it is characterised in that：The step S1, S2, S3 and S4 clean rank be C grade production district carry out, the blown film type of cooling use up-draught it is cold or under blow Water-cooling process, and the air cleaning rank in film bubble is A grades.
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