CN105412210A - Health-care food composition - Google Patents

Health-care food composition Download PDF

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Publication number
CN105412210A
CN105412210A CN201510911746.2A CN201510911746A CN105412210A CN 105412210 A CN105412210 A CN 105412210A CN 201510911746 A CN201510911746 A CN 201510911746A CN 105412210 A CN105412210 A CN 105412210A
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health
extract
food composition
care food
radix astragali
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CN201510911746.2A
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杨石
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Individual
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/074Ganoderma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention belongs to the technical field of health-care food, and particularly relates to a health-care food composition. The health-care food composition is characterized by being prepared from an astragalus extract and a ganoderma extract. Through years of clinical research, by combining modern medical tests, the astragalus extract is greatly used in the formula and cooperates with ganoderma to be used for treating a Qi-deficiency patient who is low in immune function.

Description

A kind of health-care food composition
Technical field
The present invention relates to technical field of health care food, be specifically related to a kind of health-care food composition.
Background technology
Body immunity is the ability that people resist environment and virus.Our health is all faced with the invasion and attack of antibacterial, virus all the time, normal immunocompetence can help us to resist the invasion and attack of exotic, body is made to be in the state of a relatively stable and dynamic equilibrium, ensure that the vis medicatrix naturae of health is played, thus make our health can from the hardship of disease.
Hypoimmunity is a kind of form of expression that immunologic function suffers damage, and the crowd of hypoimmunity is easily infected, and very easily cause the infection such as antibacterial, virus, fungus, it the most directly shows as liable to illness.Also can with performances such as lethargy, fatigue and weak, loss of appetite, sleep disorder.
The immunity that modern medicine is thought said to the traditional Chinese medical science " healthy energy " is similar, the living matter of general reference human normal and functional activity thereof.Chinese medicine is thought " healthy energy deposit in, heresy can not be done "; " gathering of heresy, its gas must be empty ".Healthy energy be the evil sequela of human body sense whether, the key of prognosis of disease, prognosis quality.Therefore, the traditional Chinese medical science, mainly through QI invigorating and body resistance strengthening, makes QI and blood keep normal physiological function, and make body keep QI and blood gentle, the steady statue of YIN and YANG in a relative equilibrium, to reach the effect of enhancing human body immunity.
Summary of the invention
For these reasons, applicant, through clinical research for many years, in conjunction with modern medicine test, reuses Radix Astragali extract, is aided with Ganoderma, thus be used for the treatment of the patient that immunologic hypofunction belongs to the deficiency of vital energy in prescription.
The present invention is directed to immunologic hypofunction belong to the crowd of the deficiency of vital energy and establish, the choose reasonable Radix Astragali, Ganoderma compatibility, the Radix Astragali is sweet, tepor, returns lung, spleen channel, and Ganoderma is sweet, flat, and GUIXIN, lung, liver, kidney channel, have the merit of QI invigorating and body resistance strengthening.Both share, and play the merit that QI invigorating and body resistance strengthening consolidates altogether, and do not have incompatibility.Meanwhile, in conjunction with modern medicine and threpsology to the achievement in research improving immunity of organisms, composition has the compositions of enhancing immunity health care.
One object of the present invention is open a kind of health-care food composition; Another object of the present invention is openly a kind of health-care food composition with enhancing immunity function; The present invention also aims to the preparation method disclosing this health-care food composition.
The present invention seeks to be achieved through the following technical solutions:
1, a health-care food composition, is characterized in that compositions is made up of following raw material: Radix Astragali extract and Ganoderma extract.
2, a kind of health-care food composition according to claim 1, wherein Radix Astragali extract 15 ~ 60 weight portion, Ganoderma extract 1 ~ 10 weight portion.
3, a kind of health-care food composition according to claim 1, wherein Radix Astragali extract 20 ~ 45 weight portion, Ganoderma extract 3 ~ 6 weight portion.
4, a kind of health-care food composition according to claim 1, wherein Radix Astragali extract 30 weight portion, Ganoderma extract 4.1 weight portion.
5, a kind of health-care food composition according to any one of claim 1-4, wherein the preparation method of Radix Astragali extract is: get the Radix Astragali and add water, soak 2 hours, extract 2 times, each 2 hours, first time adds 10 times of water gagings, second time adds 8 times of water gagings, filters, filtrate reduced in volume to 60 DEG C relative density 1.25-1.30,60 DEG C of-70 DEG C of dryings, obtain Radix Astragali extract;
Wherein the preparation method of Ganoderma extract is: get Ganoderma and add water, and soaks 2 hours, extracts 2 times, each 2 hours, first time adds 10 times of water gagings, and second time adds 8 times of water gagings, filters, filtrate reduced in volume to 60 DEG C relative density 1.25-1.30,60 DEG C of-70 DEG C of dryings, obtain Ganoderma extract.
6, a kind of health-care food composition according to any one of claim 1-4, is characterized in that health-care food composition is prepared into solid preparation.
7, a kind of health-care food composition according to any one of claim 1-4 is preparing the application treated and/or prevented in the health food of hypoimmunity.
Detailed description of the invention
Enhancing immunity functional trial:
Laboratory animal: the SPF level 18-22g male mice in kunming selecting the breeding of the long-living biological company limited in Liaoning.
Test grouping:
Test 1 group: Radix Astragali extract 30g, Ganoderma extract 4.1g;
Test 2 groups: Radix Astragali extract 18g, Ganoderma extract 7g;
Test 3 groups: Radix Astragali extract 5g, Ganoderma extract 25g.
Wherein testing 1 group is the combination of present composition optimal proportion; Within the scope of the proportioning raw materials that the proportioning raw materials testing 2 groups is protected at the present composition; Outside the proportioning raw materials scope that the proportioning raw materials testing 3 groups is protected at the present composition.
The preparation method of Radix Astragali extract is: get the Radix Astragali and add water, and soaks 2 hours, extracts 2 times, each 2 hours, first time adds 10 times of water gagings, and second time adds 8 times of water gagings, filters, filtrate reduced in volume to 60 DEG C relative density 1.25-1.30,60 DEG C of-70 DEG C of dryings, obtain Radix Astragali extract;
Wherein the preparation method of Ganoderma extract is: get Ganoderma and add water, and soaks 2 hours, extracts 2 times, each 2 hours, first time adds 10 times of water gagings, and second time adds 8 times of water gagings, filters, filtrate reduced in volume to 60 DEG C relative density 1.25-1.30,60 DEG C of-70 DEG C of dryings, obtain Ganoderma extract.
Metering is selected and tested material gives mode: by 30 times (1.20g/kgBW) design recommending human body daily intaking amount, test is established test 1 group, tests 2 groups, tested 3 groups of three groups and sample solvent matched group.Take tested material 6.00g respectively, add distilled water and be adjusted to 100mL, sample preparation concentration is 6.00g/mL, Fresh during use.Gavage mode gives sample, by body weight adjustment gavage capacity, every day gavage 1 time, continuous 30 days.Last measures every immune indexes respectively to after sample 30min.
1, antibody-producting cell detects and mice serum hemolysin test result of the test:
Each test group original body mass, test opisthosoma are heavy, weight gain compares with sample solvent matched group, there was no significant difference (P>0.05); Test 1 group, test the hemolysis plaque number of 2 groups and be significantly higher than sample solvent matched group (P<0.05); Test 1 group, test the antibody product of 2 groups and be significantly higher than sample solvent matched group (P<0.05); Test the hemolysis plaque number of 3 groups, antibody product and solvent control group there was no significant difference (P>0.05).
Body weight measurements (the unit: g) that table 1 antibody-producting cell detects and serum hemolysin measures
Table 2 antibody-producting cell detects plaque number and serolysin test antibody product measurement result
2, mice carbonic clearance result of the test:
Each experimental group original body mass, test opisthosoma are heavy, weight gain compares with sample solvent matched group, there was no significant difference (P>0.05); The phagocytic index a testing 1 group is significantly higher than sample solvent matched group (P<0.05).
Table 3 mice carbonic clearance test body weight measurements (unit: g)
Table 4 mice carbonic clearance test phagocytic index a measurement result
3, Turnover of Mouse Peritoneal Macrophages engulfs chicken red blood cell result of the test:
Each experimental group original body mass, test opisthosoma are heavy, weight gain compares with sample solvent matched group, there was no significant difference (P>0.05); Test the phagocytic percentage of 1 group, phagocytic index is significantly higher than solvent control group (P<0.01); Test the phagocytic percentage of 2 groups, phagocytic index is significantly higher than solvent control group (P<0.05); Test 3 groups and solvent control group there was no significant difference (P>0.05).
Table 5 Turnover of Mouse Peritoneal Macrophages engulfs chicken red blood cell test body weight measurements (unit: g)
Table 6 Turnover of Mouse Peritoneal Macrophages engulfs chicken red blood cell test phagocytic percentage, phagocytic index measurement result
Result judges: in the immunologic function test carry out three groups of tested materials and one group of solvent control, the hemolysis plaque number testing 1 group is significantly higher than sample solvent matched group (P<0.05); Antibody product is significantly higher than sample solvent matched group (P<0.05); Carbonic clearance phagocytosis test phagocytic index a is significantly higher than sample solvent matched group (P<0.05); Macrophage phagocytic chicken red blood cell phagocytic percentage, phagocytic index are significantly higher than solvent control group (P<0.01).
The hemolysis plaque number testing 2 groups is significantly higher than sample solvent matched group (P<0.05); Antibody product is significantly higher than sample solvent matched group (P<0.05); Carbonic clearance phagocytosis test phagocytic index a and sample solvent matched group there was no significant difference (P>0.05); Macrophage phagocytic chicken red blood cell phagocytic percentage, phagocytic index are significantly higher than solvent control group (P<0.05).
Test the above-mentioned result of the test of 3 groups there are no significant compared with sample solvent matched group difference (P>0.05).Known, test 1 group, test 2 groups there is enhancing immunity function, and test 1 group is more better than test 2 groups; Test 3 groups and not there is enhancing immunity function.
Preparation embodiment:
Embodiment 1: get 30kg Radix Astragali extract, 4.17kg Ganoderma extract, add 5.43kg dextrin, mix homogeneously, granulates, adds 0.4kg magnesium stearate, mix homogeneously, loads capsule, obtains capsule.
Embodiment 2: get 25kg Radix Astragali extract, 9kg Ganoderma extract, add 5.6kg dextrin, mix homogeneously, granulates, adds 0.4kg magnesium stearate, mix homogeneously, loads capsule, obtains capsule.
Embodiment 3: get 35kg Radix Astragali extract, 2kg Ganoderma extract, add 2.5kg dextrin, mix homogeneously, granulates, adds 0.5kg magnesium stearate, mix homogeneously, loads capsule, obtains capsule.
Embodiment 4: get 30kg Radix Astragali extract, 4.17kg Ganoderma extract, adds 2.43kg dextrin, 3kg starch, 0.4kg microcrystalline Cellulose, mix homogeneously, and granulate, granulate, tabletting, obtains tablet.
Embodiment 5: get 30kg Radix Astragali extract, 4kg Ganoderma extract, adds 50kg dextrin, 15kg Icing Sugar, mix homogeneously, granulates, obtains granule.
The preparation method of Radix Astragali extract described above is: get the Radix Astragali and add water, and soaks 2 hours, extracts 2 times, each 2 hours, first time adds 10 times of water gagings, and second time adds 8 times of water gagings, filters, filtrate reduced in volume to 60 DEG C relative density 1.25-1.30,60 DEG C of-70 DEG C of dryings, obtain Radix Astragali extract;
The preparation method of wherein Ganoderma extract described above is: get Ganoderma and add water, soak 2 hours, extract 2 times, each 2 hours, first time added 10 times of water gagings, and second time adds 8 times of water gagings, filter, filtrate reduced in volume to 60 DEG C relative density 1.25-1.30,60 DEG C of-70 DEG C of dryings, obtain Ganoderma extract.

Claims (7)

1. a health-care food composition, is characterized in that compositions is made up of following raw material: Radix Astragali extract and Ganoderma extract.
2. a kind of health-care food composition according to claim 1, wherein Radix Astragali extract 15 ~ 60 weight portion, Ganoderma extract 1 ~ 10 weight portion.
3. a kind of health-care food composition according to claim 1, wherein Radix Astragali extract 20 ~ 45 weight portion, Ganoderma extract 3 ~ 6 weight portion.
4. a kind of health-care food composition according to claim 1, wherein Radix Astragali extract 30 weight portion, Ganoderma extract 4.1 weight portion.
5. a kind of health-care food composition according to any one of claim 1-4, wherein the preparation method of Radix Astragali extract is: get the Radix Astragali and add water, soak 2 hours, extract 2 times, each 2 hours, first time adds 10 times of water gagings, second time adds 8 times of water gagings, filters, filtrate reduced in volume to 60 DEG C relative density 1.25-1.30,60 DEG C of-70 DEG C of dryings, obtain Radix Astragali extract;
Wherein the preparation method of Ganoderma extract is: get Ganoderma and add water, and soaks 2 hours, extracts 2 times, each 2 hours, first time adds 10 times of water gagings, and second time adds 8 times of water gagings, filters, filtrate reduced in volume to 60 DEG C relative density 1.25-1.30,60 DEG C of-70 DEG C of dryings, obtain Ganoderma extract.
6. a kind of health-care food composition according to any one of claim 1-4, is characterized in that health-care food composition is prepared into solid preparation.
7. a kind of health-care food composition according to any one of claim 1-4 is preparing the application treated and/or prevented in the health food of hypoimmunity.
CN201510911746.2A 2015-12-11 2015-12-11 Health-care food composition Pending CN105412210A (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104815050A (en) * 2015-05-20 2015-08-05 吉林大学 Slimming and fat-burning assistant health food and preparation method thereof
CN105999096A (en) * 2016-07-07 2016-10-12 天津天狮生物发展有限公司 Composition for enhancing immunity and application
WO2019024014A1 (en) * 2017-08-02 2019-02-07 江苏安惠生物科技有限公司 Health-care capsule for enhancing immunity and relieving fatigue
CN109793811A (en) * 2019-03-26 2019-05-24 上海市农业科学院 A kind of Lingzhu ' that triple function being immunized with inhibition hyperplasia of prostate, liver protection, raising
CN111905092A (en) * 2020-09-23 2020-11-10 桂明霞 Traditional Chinese medicine preparation for removing dampness, expelling toxin and tonifying qi as well as preparation method and application thereof
CN113069484A (en) * 2021-03-12 2021-07-06 黑龙江中医药大学 Anti-aging medicine and preparation method of microcapsule preparation thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1586300A (en) * 2004-06-28 2005-03-02 陈萍 Method for preparing health food for improving immunological function
CN101780136A (en) * 2010-03-17 2010-07-21 上海大学 Medicine and food dual-purpose traditional Chinese medicine composition with anti-tumor activity and immunoregulation effect and application thereof
CN101810337A (en) * 2010-05-11 2010-08-25 苏豹 Health food containing pseudo-ginseng and ganoderma lucidum and radix astragali
CN103039955A (en) * 2012-12-28 2013-04-17 杨石 Health food with function of boosting immunity
CN103202479A (en) * 2013-05-03 2013-07-17 高益槐 Health protection food for adjusting immunity function and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1586300A (en) * 2004-06-28 2005-03-02 陈萍 Method for preparing health food for improving immunological function
CN101780136A (en) * 2010-03-17 2010-07-21 上海大学 Medicine and food dual-purpose traditional Chinese medicine composition with anti-tumor activity and immunoregulation effect and application thereof
CN101810337A (en) * 2010-05-11 2010-08-25 苏豹 Health food containing pseudo-ginseng and ganoderma lucidum and radix astragali
CN103039955A (en) * 2012-12-28 2013-04-17 杨石 Health food with function of boosting immunity
CN103202479A (en) * 2013-05-03 2013-07-17 高益槐 Health protection food for adjusting immunity function and preparation method thereof

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104815050A (en) * 2015-05-20 2015-08-05 吉林大学 Slimming and fat-burning assistant health food and preparation method thereof
CN104815050B (en) * 2015-05-20 2018-06-08 吉林大学 It is a kind of that thin body is assisted to disappear the health food and preparation method thereof of fat
CN105999096A (en) * 2016-07-07 2016-10-12 天津天狮生物发展有限公司 Composition for enhancing immunity and application
WO2019024014A1 (en) * 2017-08-02 2019-02-07 江苏安惠生物科技有限公司 Health-care capsule for enhancing immunity and relieving fatigue
CN109793811A (en) * 2019-03-26 2019-05-24 上海市农业科学院 A kind of Lingzhu ' that triple function being immunized with inhibition hyperplasia of prostate, liver protection, raising
CN111905092A (en) * 2020-09-23 2020-11-10 桂明霞 Traditional Chinese medicine preparation for removing dampness, expelling toxin and tonifying qi as well as preparation method and application thereof
CN113069484A (en) * 2021-03-12 2021-07-06 黑龙江中医药大学 Anti-aging medicine and preparation method of microcapsule preparation thereof

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