CN105399777A - Nedaplatin analogue and preparation method thereof - Google Patents
Nedaplatin analogue and preparation method thereof Download PDFInfo
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- CN105399777A CN105399777A CN201510815387.0A CN201510815387A CN105399777A CN 105399777 A CN105399777 A CN 105399777A CN 201510815387 A CN201510815387 A CN 201510815387A CN 105399777 A CN105399777 A CN 105399777A
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- analogue
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- iodine
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- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 190000005734 Nedaplatin analogue Chemical class 0.000 title abstract 5
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 238000006243 chemical reaction Methods 0.000 claims abstract description 20
- 229910001961 silver nitrate Inorganic materials 0.000 claims abstract description 14
- 238000003756 stirring Methods 0.000 claims abstract description 10
- 239000000706 filtrate Substances 0.000 claims abstract description 9
- 239000000126 substance Substances 0.000 claims abstract description 9
- 239000011541 reaction mixture Substances 0.000 claims abstract description 5
- -1 iodine ammonia platinum Chemical compound 0.000 claims description 16
- 238000001035 drying Methods 0.000 claims description 8
- 239000008213 purified water Substances 0.000 claims description 5
- 239000000376 reactant Substances 0.000 claims description 5
- 230000035484 reaction time Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- PNCHTLQBARZRSO-UHFFFAOYSA-L azane;platinum(2+);diiodide Chemical compound N.N.[I-].[I-].[Pt+2] PNCHTLQBARZRSO-UHFFFAOYSA-L 0.000 abstract 3
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 2
- 229940005574 sodium gluconate Drugs 0.000 abstract 2
- 235000012207 sodium gluconate Nutrition 0.000 abstract 2
- 239000000176 sodium gluconate Substances 0.000 abstract 2
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 239000005457 ice water Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 description 6
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940041181 antineoplastic drug Drugs 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000002932 luster Substances 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- KLNFSAOEKUDMFA-UHFFFAOYSA-N azanide;2-hydroxyacetic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OCC(O)=O KLNFSAOEKUDMFA-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229950007221 nedaplatin Drugs 0.000 description 1
- 231100000417 nephrotoxicity Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a nedaplatin analogue of which the main constituent structure is shown in a formula I. A preparation method of the nedaplatin analogue comprises the following steps: (1) dissolving silver nitrate in 10-30 times volume of water, adding cisdiiododiam mineplatinum, and stirring for a 2-5 hours' reaction to obtain a reaction mixture, wherein the mass ratio of silver nitrate to cisdiiododiam mineplatinum is 0.7:1; (2) filtering the reaction mixture by a Buchner funnel to obtain a filtrate; (3) adding sodium gluconate into the filtrate for a 2-5 hours' reaction, wherein the amount of substance of sodium gluconate is 2 times of that of cisdiiododiam mineplatinum; (4) concentrating the reaction product till dryness, adding 5-10 ml of ice water, and carrying out filtration to prepare the nedaplatin analogue. The preparation properties are stable, the nedaplatin analogue is high in purity, the reaction process is controllable, and industrialized production is easy.
Description
Technical field
The present invention relates to medicines and health protection product technical field, be specifically related to a kind of S 254 analogue and preparation method thereof.
Background technology
S 254 (nedaplatin), trade(brand)name prompt one hundred is relaxed, and is the broad-spectrum anti-cancer drug that Nanjing Xianshengdongyuan Pharmaceutical Co., Ltd produces, is a kind of good effect, the platinum kind anti-cancer drugs of a new generation that toxic side effect is few.Its water-soluble height, to various animal tumor, all show good effect under the dosage of a wider range, and renal toxicity, the digestion organs toxicity of animal are also lower.Its structural formula is shown below:
As clinical commonly used drug, in its production process, usually use polymerization sugar if dextran etc. is as vehicle.If polymerization sugar does not obtain good control in process of production, part generation depolymerization may be had, along with the generation of depolymerization, the poly-material of partial solution and main ingredient may be had and some occur act on, produce some impurity.Along with the supervision and management of state food and medicine is more and more stricter, more and more higher to the concern of the impurity in product, but little about the report of its analogue.We think that impurity is compound of the present invention.
Summary of the invention
The invention provides a kind of stable in properties, S 254 analogue that product purity is high and preparation method thereof.
To achieve these goals, the present invention is achieved through the following technical solutions: a kind of S 254 analogue of the present invention, and the structure of its main component is such as formula shown in I:
The preparation method of S 254 analogue of the present invention, comprises the steps:
(1) be dissolved in by Silver Nitrate in the water of 10-30 times of volume, add iodine ammonia platinum, stirring reaction 2-5h, the mass ratio of described Silver Nitrate and iodine ammonia platinum is 0.7:1;
(2) with the above-mentioned reaction mixture of filtered on buchner funnel;
(3) in above-mentioned filtrate, add Sunmorl N 60S, described Sunmorl N 60S amount of substance is 2 times of iodine ammonia platinum amount of substance, reaction 2-5h;
(4) above-mentioned reactant is concentrated into drying, adds 5-10mL frozen water, filter, obtained S 254 analogue.
Further, in step (1), Silver Nitrate is dissolved in the water of 15-25 times of volume, adds iodine ammonia platinum (NH
3)
2ptI
2, stirring reaction 2-5h.
Further, in step (1), 3.50g Silver Nitrate is dissolved in 30mL water, adds 5.0g iodine ammonia platinum (NH in batches
3)
2ptI
2, vigorous stirring is reacted, and the reaction times is 2-5h.
Further, in step (1), described water is purified water.
Further, in step (3), filtrate adds 4.6g Sunmorl N 60S, after reaction 3-5h,
Further, in step (4), reaction solution is less than 0.095Mpa being decompressed to, and is concentrated into drying.
Further, in step (4), add 5mL frozen water, vibration, filter, obtained 1.96g S 254 analogue.
Beneficial effect: stable in properties of the present invention, product purity is high.Preparation method is simple, and the product purity obtained is high, and reaction process is controlled, is conducive to bringing larger benefit to the product quality analysis of S 254 preparation.
Embodiment
Further illustrate the present invention by the following examples.It should be understood that these embodiments are explaination of the present invention and citing, do not limit the scope of the invention in any form.
Embodiment 1
A kind of S 254 analogue of the present invention, the structure of its main component is such as formula shown in I:
The preparation method of S 254 analogue of the present invention, comprises the steps:
(1) be dissolved in by Silver Nitrate in the purified water of 10 times of volumes, add iodine ammonia platinum, stirring reaction 2h, the mass ratio of described Silver Nitrate and iodine ammonia platinum is 0.7:1;
(2) with the above-mentioned reaction mixture of filtered on buchner funnel;
(3) in above-mentioned filtrate, add Sunmorl N 60S, described Sunmorl N 60S amount of substance is 2 times of iodine ammonia platinum amount of substance, reaction 2-5h;
(4) above-mentioned reactant is decompressed to is less than 0.095Mpa, be concentrated into drying, add 8mL frozen water, filter, obtained S 254 analogue.Be sample 1.
Embodiment 2
Embodiment 2 is with the difference of embodiment 1:
The preparation method of S 254 analogue of the present invention, comprises the steps:, in step (1), to be dissolved in by 3.50g Silver Nitrate in 30mL purified water, adds 5.0g iodine ammonia platinum (NH in batches
3)
2ptI
2, vigorous stirring is reacted, and the reaction times is 3h.
In step (3), filtrate adds 4.6g Sunmorl N 60S, and after reaction 5h, reaction solution is evaporated to drying.
In step (4), above-mentioned reactant is concentrated into drying, adds 5mL frozen water, vibration, filter, obtained 1.96g S 254 analogue.Be sample 2.
Fusing point 118-123 DEG C (decomposition).Ultimate analysis (C
6h
16n
2o
7pt) %: calculated value, C17.03, H3.81, N, 6.62, Pt, 46.09; Analytical value: C16.91, H3.97, N, 6.69, Pt, 46.39.Infrared spectra (cm-1): 3400,3270,1634,1131,1087,1041,867,821.
Embodiment 3
Embodiment 3 is with the difference of embodiment 1:
The preparation method of S 254 analogue of the present invention, comprises the steps:
In step (1), Silver Nitrate is dissolved in the purified water of 30 times of volumes, adds iodine ammonia platinum, stirring reaction 5h,
In step (3), in above-mentioned filtrate, add Sunmorl N 60S, described Sunmorl N 60S amount of substance is 2 times of iodine ammonia platinum amount of substance, reaction 3h;
In step (4), above-mentioned reactant is concentrated into drying, adds 10mL frozen water, filter, obtained S 254 analogue.Be sample 3.
Test 1
To be kept sample placement 6 months in room temperature by sample 1 to 3 in embodiment 1 to 3, compare appearance luster, the change of the indexs such as content with before placement, experimental result is as shown in table 1 below:
Table 1
As shown in table 1, sample 1 to 3 of the present invention to keep sample placement 6 months in room temperature, and compare appearance luster with before placement, the change of the indexs such as content is very little, almost unchanged, stable in properties.
More than show and describe ultimate principle of the present invention, principal character and advantage of the present invention.The technician of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and specification sheets just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and application claims protection domain is defined by appending claims, specification sheets and equivalent thereof.
Claims (8)
1. a S 254 analogue, the structure of its main component is such as formula shown in I:
2. the preparation method of S 254 analogue described in claim 1, is characterized in that comprising the steps:
(1) be dissolved in by Silver Nitrate in the water of 10-30 times of volume, add iodine ammonia platinum, stirring reaction 2-5h, the mass ratio of described Silver Nitrate and iodine ammonia platinum is 0.7:1;
(2) with the above-mentioned reaction mixture of filtered on buchner funnel;
(3) in above-mentioned filtrate, add Sunmorl N 60S, described Sunmorl N 60S amount of substance is 2 times of iodine ammonia platinum amount of substance, reaction 2-5h;
(4) above-mentioned reactant is concentrated into drying, adds 5-10mL frozen water, filter, obtained S 254 analogue.
3. the preparation method of S 254 analogue according to claim 2, is characterized in that: in step (1), be dissolved in by Silver Nitrate in the water of 15-25 times of volume, adds iodine ammonia platinum (NH
3)
2ptI
2, stirring reaction 2-5h.
4. the preparation method of S 254 analogue according to claim 2, is characterized in that: in step (1), is dissolved in by 3.50g Silver Nitrate in 30mL water, add 5.0g iodine ammonia platinum (NH in batches
3)
2ptI
2, vigorous stirring is reacted, and the reaction times is 2-5h.
5. the preparation method of S 254 analogue according to claim 2, it is characterized in that: in step (1), described water is purified water.
6. the preparation method of S 254 analogue according to claim 2, is characterized in that: in step (3), filtrate adds 4.6g Sunmorl N 60S, after reaction 3-5h.
7. the preparation method of S 254 analogue according to claim 2, is characterized in that: in step (4), and reaction solution is less than 0.095Mpa being decompressed to, and is concentrated into drying.
8. the preparation method of S 254 analogue according to claim 4 or 7, is characterized in that: in step (4), add 5mL frozen water, vibration, filters, obtained 1.96g S 254 analogue.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510815387.0A CN105399777A (en) | 2015-11-23 | 2015-11-23 | Nedaplatin analogue and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510815387.0A CN105399777A (en) | 2015-11-23 | 2015-11-23 | Nedaplatin analogue and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105399777A true CN105399777A (en) | 2016-03-16 |
Family
ID=55465572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510815387.0A Pending CN105399777A (en) | 2015-11-23 | 2015-11-23 | Nedaplatin analogue and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105399777A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4575550A (en) * | 1981-01-23 | 1986-03-11 | Shionogi & Co., Ltd. | Platinum complexes |
| CN102417522A (en) * | 2011-10-20 | 2012-04-18 | 南京工业大学 | Preparation method of nedaplatin with extremely low silver content |
-
2015
- 2015-11-23 CN CN201510815387.0A patent/CN105399777A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4575550A (en) * | 1981-01-23 | 1986-03-11 | Shionogi & Co., Ltd. | Platinum complexes |
| CN102417522A (en) * | 2011-10-20 | 2012-04-18 | 南京工业大学 | Preparation method of nedaplatin with extremely low silver content |
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| PB01 | Publication | ||
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160316 |
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| RJ01 | Rejection of invention patent application after publication |