CN105398030A - Disposable microscale capillary blood sampling plastic tube and preparation method thereof - Google Patents

Disposable microscale capillary blood sampling plastic tube and preparation method thereof Download PDF

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Publication number
CN105398030A
CN105398030A CN201510787925.XA CN201510787925A CN105398030A CN 105398030 A CN105398030 A CN 105398030A CN 201510787925 A CN201510787925 A CN 201510787925A CN 105398030 A CN105398030 A CN 105398030A
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plastic tube
blood sampling
capillary
coating
temperature
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CN201510787925.XA
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CN105398030B (en
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曾梅君
吴本强
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SHANDONG FENGYUAN MEDICAL MATERIAL CO Ltd
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SHANDONG FENGYUAN MEDICAL MATERIAL CO Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150343—Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
    • B05D3/007—After-treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
    • B05D3/02—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by baking
    • B05D3/0254—After-treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D7/00—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
    • B05D7/22—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to internal surfaces, e.g. of tubes
    • B05D7/222—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to internal surfaces, e.g. of tubes of pipes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/88—Thermal treatment of the stream of extruded material, e.g. cooling
    • B29C48/90—Thermal treatment of the stream of extruded material, e.g. cooling with calibration or sizing, i.e. combined with fixing or setting of the final dimensions of the extruded article
    • B29C48/906—Thermal treatment of the stream of extruded material, e.g. cooling with calibration or sizing, i.e. combined with fixing or setting of the final dimensions of the extruded article using roller calibration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/92—Measuring, controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2948/00—Indexing scheme relating to extrusion moulding
    • B29C2948/92—Measuring, controlling or regulating
    • B29C2948/92504—Controlled parameter
    • B29C2948/92704—Temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2948/00—Indexing scheme relating to extrusion moulding
    • B29C2948/92—Measuring, controlling or regulating
    • B29C2948/92819—Location or phase of control
    • B29C2948/92857—Extrusion unit
    • B29C2948/92876—Feeding, melting, plasticising or pumping zones, e.g. the melt itself
    • B29C2948/92885—Screw or gear
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2948/00—Indexing scheme relating to extrusion moulding
    • B29C2948/92—Measuring, controlling or regulating
    • B29C2948/92819—Location or phase of control
    • B29C2948/92923—Calibration, after-treatment or cooling zone

Abstract

The invention discloses a disposable microscale capillary blood sampling plastic tube and a preparation method thereof. The disposable microscale capillary blood sampling plastic tube is prepared through the step of plastic tube extrusion, the step of plasma gas treatment, the step of coating treatment and the step of coating drying. Due to the fact that hydrophiling treatment is conducted on an inner cavity of a plastic tube body, the hydrophobic plastic catheter has the same characteristics as a hydrophilic glass catheter; the finished plastic tube has the advantages of low in weight, not prone to breakage, high in forming rate, convenient to use, low in cost and capable of being clinically applied and popularized conveniently.

Description

Disposable micro capillary blood sampling plastic tube and preparation method thereof
Technical field
The present invention relates to a kind of disposable micro capillary blood sampling plastic tube and preparation method thereof.
Background technology
Disposable micro capillary heparin tube is mainly used in the blood sampling chemical examination of peripheral vessel or capillary.Due to convenient to use and be subject to the favor of numerous health care workers, Clinical practice is very general.Due to the capillary properties that heparin tube requires, glass is all adopted to make at present on the market.The shortcomings such as it is high that glass article has proportion, frangible, have certain defect in Product transport and use procedure.Plastic material due to quality light, non-friable, the shaping advantage such as simple fast and liking extensively by consumer; But because plastic material surface is hydrophobicity, capillary siphonage cannot be produced as the hydrophilic materials such as glass material, so body cannot be entered by automatic siphon blood under the effect of regular atmospheric pressure, thus market also seldom there is the micro-capillary heparin tube of plastic material.
Summary of the invention
For problems of the prior art, the invention provides a kind of disposable micro capillary blood sampling plastic tube and preparation method thereof.This capillary blood sampling plastic tube quality is light, and non-friable, ratio of briquetting is high, easy to use, and cost is low, is convenient to clinical practice and promotes the use of.
The present invention is by the following technical solutions:
A kind of disposable micro capillary blood sampling plastic tube, it is characterized in that, it adopts following method to prepare:
1) plastic tube is extruded: by plastic extrusion level material in dehumidifying heat pump 90 DEG C, dry 4-6 hour for subsequent use; Dried plastic raw materials joins in single screw extrusion machine, one section of temperature 140-160 DEG C is set, two sections of temperature 160-200 DEG C, three sections of temperature 200-230 DEG C, four sections of temperature 180-210 DEG C, die temperature: 210-240 DEG C, screw speed 60-120rpm, mouth mould Φ 4.2*10mm, core Φ 2.8*15mm; Extrude final vacuum sizing, vacuum 0.06-0.08Mpa, vacuum sizing sleeve diameter of phi 1.80mm, length 15mm; Stereotyped plastic tube, after water-cooled, crosses hauling machine, cuts on request and obtains capillary blood sampling plastic tube;
2) plasma gas process: the capillary of extrusion molding blood sampling plastic tube is put into vacuum seal process chamber plasma process is carried out to tube cavity;
3) coating processing: by through step 2) tubing after process carried out coating processing to tube cavity surface in 24 hours, and coat is siliceous hydrophilic coating;
4) coating drying process: the capillary plastic tube of gained after step 3) process is put in centrigugal swing dryer, parallelly to pile up, centrifugal rotational speed 1000-1500rpm, dry time 3-5 minute, to remove the unnecessary coating liquid of inner chamber; The capillary dried after process is put in drying box and carries out heat cure and further dry process, solidification temperature 65 DEG C, hardening time 1-2 hour, the taking-up that cools afterwards gets product.
Preferably, in described step 1), capillary blood sampling plastic tube outer tube diameter is 1.70 ± 0.05mm, and internal diameter 1.00 ± 0.05mm, length is 75 ± 2mm.
Preferably, in described step 1), plastic raw materials is PET.
Preferably, described step 2) in plasma treatment conditions be: plasma treatment gas is air, and in process chamber, vacuum is 13-65Pa, and voltage is 500V, and power is 300-450W, processing time 30-60s.
Preferably, in described step 3), painting method is be dissolved in the water by siliceous hydrophilic coating to be mixed with the weak solution that concentration is 2.5%, leaves standstill stand-by after 24 hours; Adopt micro-flow pump to carry out the pumping of coating solution, φ 0.50mm inhales plastic pin and pours into tubing inner chamber, keeps perfusion flow velocity to be 5-15mL/ second, injection pressure 0.03-0.0.05Mpa, often props up capillary perfusion and continues 5-15s; Described siliceous hydrophilic coating is CaSiO 3, Na 2siO 3or SiO 2; Coat thickness is at 10-50 μm.
A preparation method for above-mentioned micro-capillary blood sampling plastic tube, it is characterized in that, it comprises the following steps:
1) plastic tube is extruded: by plastic extrusion level material in dehumidifying heat pump 90 DEG C, dry 4-6 hour for subsequent use; Dried plastic raw materials joins in single screw extrusion machine, one section of temperature 140-160 DEG C is set, two sections of temperature 160-200 DEG C, three sections of temperature 200-230 DEG C, four sections of temperature 180-210 DEG C, die temperature: 210-240 DEG C, screw speed 60-120rpm, mouth mould Φ 4.2*10mm, core Φ 2.8*15mm; Extrude final vacuum sizing, vacuum 0.06-0.08Mpa, vacuum sizing sleeve diameter of phi 1.80mm, length 15mm; Stereotyped plastic tube, after water-cooled, crosses hauling machine, cuts on request and obtains capillary blood sampling plastic tube;
2) plasma gas process: the capillary of extrusion molding blood sampling plastic tube is put into vacuum seal process chamber plasma process is carried out to tube cavity;
3) coating processing: by through step 2) tubing after process carried out coating processing to tube cavity surface in 24 hours, and coat is hydrophilic calcium silicon coating;
4) coating drying process: the capillary plastic tube of gained after step 3) process is put in centrigugal swing dryer, parallelly to pile up, centrifugal rotational speed 1000-1500rpm, dry time 3-5 minute, to remove the unnecessary coating liquid of inner chamber; The capillary dried after process is put in drying box and carries out heat cure and further dry process, solidification temperature 65 DEG C, hardening time 1-2 hour, the taking-up that cools afterwards gets product.
In step 1) described in described step 1), plastic tube raw material is PET; Described capillary blood sampling plastic tube outer tube diameter is 1.70 ± 0.05mm, and internal diameter 1.00 ± 0.05mm, length is 75 ± 2mm.
Described step 2) in plasma treatment conditions be: plasma treatment gas is air, and in process chamber, vacuum is 13-65Pa voltage is 500V, and power is 300-450W, processing time 30-60s.
In described step 3), painting method is: being dissolved in the water by siliceous hydrophilic coating is mixed with the weak solution that concentration is 2.5%, leaves standstill stand-by after 24 hours; Adopt micro-flow pump to carry out the pumping of coating solution, φ 0.50mm inhales plastic pin and pours into tubing inner chamber, keeps perfusion flow velocity to be 5-15mL/ second, injection pressure 0.03-0.0.05Mpa, often props up capillary perfusion and continues 5-15s; Described siliceous hydrophilic coating is CaSiO 3, Na 2siO 3or SiO 2; Coat thickness is at 10-50 μm.
The invention has the beneficial effects as follows: product of the present invention adopts PET to be that material extruding is shaping, adopt plasma process and the design of paint layer simultaneously, hydrophilicity-imparting treatment is carried out to plastic tube body inner chamber, make hydrophobic plastic catheter be provided with the characteristic identical with hydrophilic glass conduit, its finished product has that quality is light, non-friable, ratio of briquetting is high, easy to use, cost is low, be convenient to clinical practice and the advantage such as promote the use of.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.
Embodiment 1
A kind of disposable micro capillary blood sampling plastic tube, it adopts following method to prepare:
1) plastic tube is extruded: by plastic extrusion level material in dehumidifying heat pump 90 DEG C, dry 4 hours for subsequent use; Dried plastic raw materials joins in single screw extrusion machine, arranges one section of temperature 140 DEG C, two sections of temperature 160 DEG C, three sections of temperature 200 DEG C, four sections of temperature 180 DEG C, die temperature: 210 DEG C, screw speed 60rpm, mouth mould Φ 4.2*10mm, core Φ 2.8*15mm; Extrude final vacuum sizing, vacuum 0.06Mpa, vacuum sizing sleeve diameter of phi 1.80mm, length 15mm; Capillary blood sampling plastic tube outer tube diameter is 1.70 ± 0.05mm, internal diameter 1.00 ± 0.05mm; Stereotyped plastic tube, after water-cooled, crosses hauling machine, cuts into the capillary blood sampling plastic tube that length is 75 ± 2mm;
2) plasma gas process: the capillary of extrusion molding blood sampling plastic tube is put into vacuum seal process chamber plasma process is carried out to tube cavity; Plasma treatment gas is air, and in process chamber, vacuum is 13-65Pa, and voltage is 500V, and power is 300W, processing time 30s.
3) coating processing: by through step 2) tubing after process carried out coating processing to tube cavity surface in 24 hours, and coat is Na 2siO 3, concrete grammar is by hydrophilic Na 2siO 3coating is dissolved in the water and is mixed with the weak solution that concentration is 2.5%, leaves standstill stand-by after 24 hours; Adopt micro-flow pump to carry out the pumping of coating solution, φ 0.50mm inhales plastic pin and pours into tubing inner chamber, keeps perfusion flow velocity to be 5mL/ second, injection pressure 0.03Mpa, often props up capillary perfusion and continues 5s; Coat thickness is at 10 μm;
4) coating drying process: the capillary plastic tube of gained after step 3) process is put in centrigugal swing dryer, parallelly to pile up, centrifugal rotational speed 1000rpm, dry 3 minutes time, to remove the unnecessary coating liquid of inner chamber; The capillary dried after process is put in drying box and carries out heat cure and dry process further, and solidification temperature 65 DEG C, 1 hour hardening time, the taking-up that cools afterwards gets product.
Micro-capillary blood sampling plastic tube yield rate prepared by said method is 98%.
Embodiment 2
A kind of disposable micro capillary blood sampling plastic tube, it adopts following method to prepare:
1) plastic tube is extruded: by plastic extrusion level material in dehumidifying heat pump 90 DEG C, dry 6 hours for subsequent use; Dried plastic raw materials joins in single screw extrusion machine, arranges one section of temperature 160 DEG C, two sections of temperature 200 DEG C, three sections of temperature 230 DEG C, four sections of temperature 210 DEG C, die temperature: 240 DEG C, screw speed 120rpm, mouth mould Φ 4.2*10mm, core Φ 2.8*15mm; Extrude final vacuum sizing, vacuum 0.08Mpa, vacuum sizing sleeve diameter of phi 1.80mm, length 15mm; Capillary blood sampling plastic tube outer tube diameter is 1.70 ± 0.05mm, internal diameter 1.00 ± 0.05mm; Stereotyped plastic tube, after water-cooled, crosses hauling machine, cuts into the capillary blood sampling plastic tube that length is 75 ± 2mm;
2) plasma gas process: the capillary of extrusion molding blood sampling plastic tube is put into vacuum seal process chamber plasma process is carried out to tube cavity; Plasma treatment gas is air, and in process chamber, vacuum is 65Pa, and voltage is 500V, and power is 450W, processing time 60s.
3) coating processing: by through step 2) tubing after process carried out coating processing to tube cavity surface in 24 hours, and coat is CaSiO 3, concrete grammar is by hydrophilic CaSiO 3coating is dissolved in the water and is mixed with the weak solution that concentration is 2.5%, leaves standstill stand-by after 24 hours; Adopt micro-flow pump to carry out the pumping of coating solution, φ 0.50mm inhales plastic pin and pours into tubing inner chamber, keeps perfusion flow velocity to be 15mL/ second, injection pressure 0.0.05Mpa, often props up capillary perfusion and continues 15s; Coat thickness is at 50 μm;
4) coating drying process: the capillary plastic tube of gained after step 3) process is put in centrigugal swing dryer, parallelly to pile up, centrifugal rotational speed 1500rpm, dry 5 minutes time, to remove the unnecessary coating liquid of inner chamber; The capillary dried after process is put in drying box and carries out heat cure and dry process further, and solidification temperature 65 DEG C, 2 hours hardening times, the taking-up that cools afterwards gets product.
Micro-capillary blood sampling plastic tube yield rate prepared by said method is 99%.
Embodiment 3
A kind of disposable micro capillary blood sampling plastic tube, it adopts following method to prepare:
1) plastic tube is extruded: by plastic extrusion level material in dehumidifying heat pump 90 DEG C, dry 5 hours for subsequent use; Dried plastic raw materials joins in single screw extrusion machine, arranges one section of temperature 150 DEG C, two sections of temperature 180 DEG C, three sections of temperature 220 DEG C, four sections of temperature 200 DEG C, die temperature: 230 DEG C, screw speed 100rpm, mouth mould Φ 4.2*10mm, core Φ 2.8*15mm; Extrude final vacuum sizing, vacuum 0.07Mpa, vacuum sizing sleeve diameter of phi 1.80mm, length 15mm; Capillary blood sampling plastic tube outer tube diameter is 1.70 ± 0.05mm, internal diameter 1.00 ± 0.05mm; Stereotyped plastic tube, after water-cooled, crosses hauling machine, cuts into the capillary blood sampling plastic tube that length is 75 ± 2mm;
2) plasma gas process: the capillary of extrusion molding blood sampling plastic tube is put into vacuum seal process chamber plasma process is carried out to tube cavity; Plasma treatment gas is air, and in process chamber, vacuum is 35Pa, and voltage is 500V, and power is 400W, processing time 50s.
3) coating processing: by through step 2) tubing after process carried out coating processing to tube cavity surface in 24 hours, and coat is SiO 2, concrete grammar is by hydrophilic SiO 2coating is dissolved in the water and is mixed with the weak solution that concentration is 2.5%, leaves standstill stand-by after 24 hours; Adopt micro-flow pump to carry out the pumping of coating solution, φ 0.50mm inhales plastic pin and pours into tubing inner chamber, keeps perfusion flow velocity to be 10mL/ second, injection pressure 0.04Mpa, often props up capillary perfusion and continues 10s; Coat thickness is at 30 μm;
4) coating drying process: the capillary plastic tube of gained after step 3) process is put in centrigugal swing dryer, parallelly to pile up, centrifugal rotational speed 1200rpm, dry 4 minutes time, to remove the unnecessary coating liquid of inner chamber; The capillary dried after process is put in drying box and carries out heat cure and dry process further, and solidification temperature 65 DEG C, 1.5 hours hardening times, the taking-up that cools afterwards gets product.
Micro-capillary blood sampling plastic tube yield rate prepared by said method is 97%.
Although embodiment of the present invention are open as above, but it is not restricted to listed in description and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the universal that claim and equivalency range limit, the present invention is not limited to specific details and description.

Claims (9)

1. a disposable micro capillary blood sampling plastic tube, is characterized in that, it adopts following method to prepare:
1) plastic tube is extruded: by plastic extrusion level material in dehumidifying heat pump 90 DEG C, dry 4-6 hour for subsequent use; Dried plastic raw materials joins in single screw extrusion machine, one section of temperature 140-160 DEG C is set, two sections of temperature 160-200 DEG C, three sections of temperature 200-230 DEG C, four sections of temperature 180-210 DEG C, die temperature: 210-240 DEG C, screw speed 60-120rpm, mouth mould Φ 4.2*10mm, core Φ 2.8*15mm; Extrude final vacuum sizing, vacuum 0.06-0.08Mpa, vacuum sizing sleeve diameter of phi 1.80mm, length 15mm; Stereotyped plastic tube, after water-cooled, crosses hauling machine, cuts on request and obtains capillary blood sampling plastic tube;
2) plasma gas process: the capillary of extrusion molding blood sampling plastic tube is put into vacuum seal process chamber plasma process is carried out to tube cavity;
3) coating processing: by through step 2) tubing after process carried out coating processing to tube cavity surface in 24 hours, and coat is siliceous hydrophilic coating;
4) coating drying process: the capillary plastic tube of gained after step 3) process is put in centrigugal swing dryer, parallelly to pile up, centrifugal rotational speed 1000-1500rpm, dry time 3-5 minute, to remove the unnecessary coating liquid of inner chamber; The capillary dried after process is put in drying box and carries out heat cure and further dry process, solidification temperature 65 DEG C, hardening time 1-2 hour, the taking-up that cools afterwards gets product.
2. micro-capillary blood sampling plastic tube according to claim 1, is characterized in that, in described step 1), capillary blood sampling plastic tube outer tube diameter is 1.70 ± 0.05mm, and internal diameter 1.00 ± 0.05mm, length is 75 ± 2mm.
3. micro-capillary blood sampling plastic tube according to claim 1, it is characterized in that, in described step 1), plastic raw materials is PET.
4. micro-capillary blood sampling plastic tube according to claim 1, is characterized in that, described step 2) in plasma treatment conditions be: plasma treatment gas is air, in process chamber, vacuum is 13-65Pa, voltage is 500V, and power is 300-450W, processing time 30-60s.
5. micro-capillary blood sampling plastic tube according to claim 1, it is characterized in that, in described step 3), painting method is be dissolved in the water by siliceous hydrophilic coating to be mixed with the weak solution that concentration is 2.5%, leaves standstill stand-by after 24 hours; Adopt micro-flow pump to carry out the pumping of coating solution, φ 0.50mm inhales plastic pin and pours into tubing inner chamber, keeps perfusion flow velocity to be 5-15mL/ second, injection pressure 0.03-0.0.05Mpa, often props up capillary perfusion and continues 5-15s; Described siliceous hydrophilic coating is CaSiO 3, Na 2siO 3or SiO 2, coat thickness is at 10-50 μm.
6. a preparation method for micro-capillary blood sampling plastic tube according to claim 1, it is characterized in that, it comprises the following steps:
1) plastic tube is extruded: PET extrusion grade material in dehumidifying heat pump 90 DEG C, dry 4-6 hour for subsequent use; Dried PET raw material joins in single screw extrusion machine, one section of temperature 140-160 DEG C is set, two sections of temperature 160-200 DEG C, three sections of temperature 200-230 DEG C, four sections of temperature 180-210 DEG C, die temperature: 210-240 DEG C, screw speed 60-120rpm, mouth mould Φ 4.2*10mm, core Φ 2.8*15mm; Extrude final vacuum sizing, vacuum 0.06-0.08Mpa, vacuum sizing sleeve diameter of phi 1.80mm, length 15mm; Stereotyped plastic tube, after water-cooled, crosses hauling machine, cuts on request and obtains capillary blood sampling plastic tube;
2) plasma gas process: the capillary of extrusion molding blood sampling plastic tube is put into vacuum seal process chamber plasma process is carried out to tube cavity;
3) coating processing: by through step 2) tubing after process carried out coating processing to tube cavity surface in 24 hours, and coat is siliceous hydrophilic coating;
4) coating drying process: the capillary plastic tube of gained after step 3) process is put in centrigugal swing dryer, parallelly to pile up, centrifugal rotational speed 1000-1500rpm, dry time 3-5 minute, to remove the unnecessary coating liquid of inner chamber; The capillary dried after process is put in drying box and carries out heat cure and further dry process, solidification temperature 65 DEG C, hardening time 1-2 hour, the taking-up that cools afterwards gets product.
7. preparation method according to claim 6, is characterized in that, in described step 1), plastic tube raw material is PET; Described capillary blood sampling plastic tube outer tube diameter is 1.70 ± 0.05mm, and internal diameter 1.00 ± 0.05mm, length is 75 ± 2mm.
8. preparation method according to claim 6, is characterized in that, described step 2) in plasma treatment conditions be: plasma treatment gas is air, in process chamber, vacuum is 13-65Pa, voltage is 500V, and power is 300-450W, processing time 30-60s.
9. preparation method according to claim 6, is characterized in that, in described step 3), painting method is: being dissolved in the water by siliceous hydrophilic coating is mixed with the weak solution that concentration is 2.5%, leaves standstill stand-by after 24 hours; Adopt micro-flow pump to carry out the pumping of coating solution, φ 0.50mm inhales plastic pin and pours into tubing inner chamber, keeps perfusion flow velocity to be 5-15mL/ second, injection pressure 0.03-0.0.05Mpa, often props up capillary perfusion and continues 5-15s; Described siliceous hydrophilic coating is CaSiO 3, Na 2siO 3or SiO 2, coat thickness is at 10-50 μm.
CN201510787925.XA 2015-11-17 2015-11-17 Disposable micro capillary blood sampling plastic tube and preparation method thereof Active CN105398030B (en)

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Application Number Priority Date Filing Date Title
CN201510787925.XA CN105398030B (en) 2015-11-17 2015-11-17 Disposable micro capillary blood sampling plastic tube and preparation method thereof

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Application Number Priority Date Filing Date Title
CN201510787925.XA CN105398030B (en) 2015-11-17 2015-11-17 Disposable micro capillary blood sampling plastic tube and preparation method thereof

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CN105398030A true CN105398030A (en) 2016-03-16
CN105398030B CN105398030B (en) 2017-10-27

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Publication number Priority date Publication date Assignee Title
WO2020128632A3 (en) * 2018-12-21 2020-09-03 Crannmed Limited A tube having an interior lubricious coating and systems and methods of applying the same
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