CN105381259B - A kind of Chinese medicine composition preparation method that treating gastritis and preparation - Google Patents
A kind of Chinese medicine composition preparation method that treating gastritis and preparation Download PDFInfo
- Publication number
- CN105381259B CN105381259B CN201510942862.0A CN201510942862A CN105381259B CN 105381259 B CN105381259 B CN 105381259B CN 201510942862 A CN201510942862 A CN 201510942862A CN 105381259 B CN105381259 B CN 105381259B
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- preparation
- powder
- chinese medicine
- medicinal extract
- medicine composition
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Abstract
The present invention relates to a kind of preparation methods of Chinese medicine composition, in particular to the preparation method for treating the Chinese medicine composition of gastritis and the pharmaceutical preparation prepared with this method.Product prepared by the method for the present invention has the characteristics that stability is good, therapeutic effect is significant.
Description
Invention field
The present invention relates to a kind of preparation methods of Chinese medicine composition, in particular to are used to treat the Chinese medicine composition of gastritis
Preparation method and the pharmaceutical preparation prepared with this method.
Background technique
MOLUO DAN is a kind of harmonizing stomach and lowering adverse Qi, invigorating the spleen dissipate-swelling, the drug of dredging collateral to stop pain.For atrophic gastritis and stomach
Pain, turgor, ruffian is bored, indigestion and loss of appetite, belch, heartburn to wait diseases.Usage and dosage takes orally, and 9~18g of honeyed bolus 3 times a day uses rice before meals
Soup or warm water are sent down, or are followed the doctor's advice.Its by lily, Radix Ophiopogonis, dendrobium nobile, Poria cocos, Rhizoma Atractylodis Macrocephalae (bran stir-fry), the root of three-nerved spicebush, Radix Paeoniae Alba, Radix Notoginseng, prolong
The 18 taste Chinese medicines such as Hu Suo (vinegar toast), endothelium corneum gigeriae galli (stir-frying), radix scrophulariae, Radix Angelicae Sinensis are prepared, and pharmacological action is as follows
1 effect: Radix Angelicae Sinensis has inhibiting effect, the total soap of Radix Notoginseng to shigella dysenteriae, comma bacillus, proteus, Escherichia coli
Glucoside has certain fungies to be acted on compared with high inhibition.
2 gastric mucosas: we have repair to gastric mucosa damage.
The 3 reason research roots of three-nerved spicebush have dual regulation that is excited and inhibiting to gastrointestinal smooth muscle, promote digestive juice secretion；Chicken
Interior gold improves gastric secretion, acidity and digestion power.
4 immune functions: according to pharmacological experiment Poria cocos, Rhizoma Atractylodis Macrocephalae in addition to invigorating the spleen, humoral immune function is effectively improved.
Radix Notoginseng, Radix Angelicae Sinensis, Poria cocos etc. all have protect liver, relieving alcohol hepatotoxicity in 5 pharmacology discovery we, and serum in liver is promoted to turn
The function of change.
Chinese patent discloses the formula as below of MOLUO DAN preparation
The Rhizoma Atractylodis Macrocephalae is fried with bran, and rhizoma corydalis is processed with vinegar, and endothelium corneum gigeriae galli selects Endothelium Corneum Gigeriae Galli (parched).
And preparation method:
Above 18 taste, adds water to cook 1-3 times, 1.5-3 hours each, collecting decoction, and filtration, filtrate is concentrated into right amount,
Ethyl alcohol is added, makes alcohol content up to 60-80%, stands, ethyl alcohol is recycled in filtration, and filtrate concentration adds water cooling to hide, filters, finally pass through
Normal process steps are directly or clinically-acceptable dosage form is made in the pharmaceutically acceptable excipients of addition.
Chinese patent 200710120838.4 discloses the following content assaying method of MOLUO DAN,
Assay is as follows:
According to high effective liquid chromatography for measuring；
Chromatographic condition and system suitability test: being filler with octadecylsilane chemically bonded silica；With 15-60:40-85
Acetonitrile-water be mobile phase；Detection wavelength is 230nm, and number of theoretical plate is calculated by Paeoniflorin peak should be not less than 1000~5000；
The preparation of reference substance solution: it is appropriate that precision weighs Paeoniflorin reference substance, solubilizer methanol, ethyl alcohol, n-butanol, water,
Chloroform or ethyl acetate be made the solution of every 1ml μ containing 30-50 g to get；
The preparation of test solution: the big honeyed bolus under MOLUO DAN small honey pill or weight differential item is taken, is shredded, precision weighs 1
~10g is added 1~10g of diatomite, grinds well, set in stuffed conical flask, and solvent methanol, ethyl alcohol, n-butanol, water, three is added in precision
Chloromethanes or ethyl acetate 15-25ml, close plug, weighing, ultrasonic treatment or heat reflux or cold soaking extract 30 minutes, and taking-up is put to room
It weighs after temperature, complements to 15-25ml with solvent methanol, ethyl alcohol, n-butanol, water, chloroform or ethyl acetate and shake up, filter,
Precision draws subsequent filtrate 4-6ml, sets in 10ml measuring bottle, solubilizer methanol, ethyl alcohol, n-butanol, water, chloroform or ethyl acetate
Be diluted to scale, shake up to get；
Measuring method: accurate absorption reference substance solution and each 20 μ l of test solution respectively, injection liquid chromatograph, measurement,
To obtain the final product；The every 1g of MOLUO DAN in terms of Paeoniflorin C23H28O11, must not be less than 0.8mg containing Radix Paeoniae Alba.
The present inventor has found that the prior art is in curative effect, stability, saving of raw material etc. in clinical and production practices
It needs to improve, to improve the effect of drug, extends shelf life, reduce the usage amount of drug, improve the adaptability of drug, be this
Inventor improves the prior art, so as to complete the present invention.
Summary of the invention:
For the defect for improving the prior art, the present invention provides a kind of new preparation method of MOLUO DAN, side of the present invention
Method is formulated as follows:
Preparation method is as follows:
Lily, Radix Notoginseng, endothelium corneum gigeriae galli, cattail pollen, rhizoma corydalis, acorus graminens soland, Poria cocos, rhizoma alismatis, nine taste medicine of Radix Paeoniae Alba (20-100%)
It is ground into 80-200 mesh powder；Remaining flavour of a drug add water to cook 2-4 times, 0.5-3 hours each, merge medical fluid filtration and are concentrated into relatively
The dilute cream of density 1.10-1.20, ethyl alcohol, which is added, makes alcohol content up to 50-80%, stands 1-5 days；Ethanol recycling ethyl alcohol is concentrated into
Relative density to 1.10-1.50 medicinal extract；Powder mixes with medicinal extract, obtains pharmaceutically active substance, by formulation method, is prepared into
Pharmaceutical preparations composition.
Preferably, of the invention the preparation method is as follows:
Lily, Radix Notoginseng, endothelium corneum gigeriae galli, cattail pollen, rhizoma corydalis, acorus graminens soland, Poria cocos, rhizoma alismatis, nine taste medicine of Radix Paeoniae Alba (20-100%)
It is ground into 100 mesh powder；Remaining flavour of a drug add water to cook 3 times, 2 hours every time, merge medical fluid filtration and are concentrated into relative density 1.10-
1.20 dilute cream, ethyl alcohol, which is added, makes alcohol content up to 65%, stands 3 days；Ethanol recycling ethyl alcohol is concentrated into relative density extremely
1.10-1.50 medicinal extract；Powder mixes with medicinal extract, obtains pharmaceutically active substance, by formulation method, is prepared into pharmaceutical preparation group
Close object.
Currently preferred preparation preparation method is as follows, and condensed pill is made in pill, drying；Or powder mixed with medicinal extract,
Capsule or tablet is made in granulation, drying；Or powder is mixed with medicinal extract, dries, is crushed, every 1 parts by weight of medicinal powder add after crushing
Concentration honeyed bolus is made in 0.6-1.5 parts by weight refined honey.
Compared to the prior art, main active obviously increases method of the invention, and drug effect significantly improves, preparation stabilization
Property significantly improves,
Illustrate beneficial effects of the present invention below by way of experimental data:
Experiment content:
The present invention and the prior art compare experiment
Experiment 1, the influence that rat acute mucosal lesion is caused to acidic ethanol
Animal packet administration is deprived of food but not water 48h in the 7th day groups of animals is administered respectively, and groups of animals fills again before testing
(water) is administered 1 time in stomach, and (150mmol/L hydrochloric acid and 60% ethyl alcohol are mixed in 1: 1 ratio by every rat oral gavage acidic ethanol 2ml after 2h
Close), it is lethal with excessive etherization rat respectively after 1h, it opens abdomen and takes stomach, with clamp cardia, 1% formaldehyde is injected by pylorus
Solution 5ml clamps pylorus, full stomach is placed in 1% formalin and fixes 10min, is cut off along greater curvature, stomach is turned up, with clear
Water gently washes away content, and stomach is laid on glass plate, mucosal lesion length is measured with precimeter, with damaged length
(lesion width, which is greater than 1mm person, to be doubled to calculate) summation calculates inhibiting rate as gastric mucosal damage index.
Experimental result is as follows:
From result as it can be seen that each group gastric mucosa has a different degrees of damage, of the present invention group and prior art group are compared with mould
Type control group is light, and damage index is substantially reduced (P < 0.05).
The comparison of rat regenerated mucosa thickness
| Group | Number of animals (only) | Regenerated mucosa thickness (μm) |
| Control group | 10 | 421 |
| Model group | 10 | 101 |
| Of the present invention group | 10 | 342 |
| Prior art group | 10 | 302 |
The comparison of ulcer stove granulation scar thickness degree
| Group | Number of animals (only) | Granulation scar thickness degree (μm) |
| Control group | 10 | 0 |
| Model group | 10 | 0.621 |
| Of the present invention group | 10 | 0.162 |
| Prior art group | 10 | 0.241 |
Test 2, the influence to rat gastric secretion
Animal packet administration, every group of 10 rats, groups of animals difference is fasting for solids and liquids for 24 hours after the last administration, with ether fiber crops
It is liquor-saturated, osculum is cut off along ventrimeson, gently pulls out stomach, ligatures pylorus, then by duodenal administration 1 time, suturing them notch, after 6h
Fu jie of taking out stitches out pricks cardia, extracts full stomach, cleans bloodstain with filter paper, cuts off stomach wall along greater curvature, pour out gastric content, be collected in
In graduated centrifuge tube, 10min is centrifuged with 1500r/min speed, accurate to record gastric juice amount, for indicator to measure gastric juice total with phenol red
Acidity measures pepsin activity using wheat spy's capillary tube method.
Experimental result is as follows:
From result as it can be seen that of the present invention group and prior art group can reduce total acidity gastric juice and pepsin activity.
Test 3, internal antibacterial tests:
Of the present invention group and prior art group can reduce infection of staphylococcus aureus dead mouse number, and it is small to extend infection
The survival number of days of mouse；
Experimental result is as follows:
| Group | Number of animals (only) | Death toll (only) | Survival rate % |
| Normal group | 20 | 0 | 100 |
| Model group | 20 | 12 | 40 |
| Of the present invention group | 20 | 5 | 75 |
| Prior art group | 20 | 9 | 55 |
Test 4. anti-inflammation test results:
Of the present invention group and prior art group can reduce dimethylbenzene induced mice auricle swelling degree.
(vola pedis thickness difference mm) is influenced on mouse delayed allergy (vola pedis thickens method)
| Dosage group | Number of animals (only) | Swelling degree of the paw (mm) for 24 hours after injection |
| Negative control group | 10 | 0.213 |
| Of the present invention group | 10 | 0.462 |
| Prior art group | 10 | 0.341 |
Experiment 5, accelerated stability experiment
Sample is placed on 40 DEG C ± 2 DEG C, is placed in climatic chamber under conditions of relative humidity 75% ± 5%, with
Setting time sampling carries out assay to related ingredient, and the primary stability test result after test is as follows
Primary stability test result after sampling test of the present invention
Primary stability test result after prior art sampling test
Advantages of the present invention is mainly manifested in:
By improving preparation method, achieves following technical effect: reducing the dose of drug, the content of active constituent
It increases, preparation stability increases, and the curative effect of drug increases.
Specific embodiment:
The present invention is further illustrated by the following examples, but not as limitation of the present invention.
Embodiment 1
Preparation method is as follows:
Lily, Radix Notoginseng, endothelium corneum gigeriae galli, cattail pollen, rhizoma corydalis, acorus graminens soland, Poria cocos, nine taste medicinal powder of Radix Ophiopogonis are broken into 100 mesh powder；
Remaining flavour of a drug add water to cook 3 times, 2 hours every time, merge the dilute cream that medical fluid filtration is concentrated into relative density 1.10-1.20, are added
Ethyl alcohol makes alcohol content up to 65%, stands 3 days；Ethanol recycling ethyl alcohol, the medicinal extract for being concentrated into relative density to 1.10-1.50；Powder
End mixes with medicinal extract, obtains pharmaceutically active substance, and condensed pill is made in pill, drying；Or powder is mixed with medicinal extract, is pelletized, is dry
Capsule or tablet is made；Or powder is mixed with medicinal extract, dries, is crushed, every 1 parts by weight of medicinal powder add 0.6-1.5 weight after crushing
Concentration honeyed bolus is made in part refined honey.
Embodiment 2
Preparation method is as follows:
Lily, Radix Notoginseng, endothelium corneum gigeriae galli, cattail pollen, rhizoma corydalis, acorus graminens soland, Poria cocos, rhizoma alismatis, nine taste medicine of Radix Paeoniae Alba (20-100%)
It is ground into 80-200 mesh powder；Remaining flavour of a drug add water to cook 2-4 times, 0.5-3 hours each, merge medical fluid filtration and are concentrated into relatively
The dilute cream of density 1.10-1.20, ethyl alcohol, which is added, makes alcohol content up to 50-80%, stands 1-5 days；Ethanol recycling ethyl alcohol is concentrated into
Relative density to 1.10-1.50 medicinal extract；Powder mixes with medicinal extract, obtains pharmaceutically active substance, and concentration is made in pill, drying
Ball；Or powder is mixed with medicinal extract, is pelletized, capsule or tablet is made in drying；Or powder is mixed with medicinal extract, dries, is crushed, and is crushed
Every 1 parts by weight of medicinal powder add 0.6-1.5 parts by weight refined honey that concentration honeyed bolus is made afterwards.
Embodiment 3
Preparation method is as follows:
Lily, Radix Notoginseng, endothelium corneum gigeriae galli, cattail pollen, rhizoma corydalis, acorus graminens soland, Poria cocos, rhizoma alismatis, nine taste medicine of Radix Paeoniae Alba (20-100%)
It is ground into 80-200 mesh powder；Remaining flavour of a drug add water to cook 2-4 times, 0.5-3 hours each, merge medical fluid filtration and are concentrated into relatively
The dilute cream of density 1.10-1.20, ethyl alcohol, which is added, makes alcohol content up to 50-80%, stands 1-5 days；Ethanol recycling ethyl alcohol is concentrated into
Relative density to 1.10-1.50 medicinal extract；Powder mixes with medicinal extract, condensed pill is made in pill, drying；Or powder and medicinal extract mix
It closes, pelletize, capsule or tablet is made in drying；Or powder is mixed with medicinal extract, dries, is crushed, every 1 parts by weight of medicinal powder add after crushing
Concentration honeyed bolus is made in 0.6-1.5 parts by weight refined honey.
The sample of above embodiments method preparation, measures by content determination: every 1g is containing Radix Paeoniae Alba with Paeoniflorin C23H28O11
Meter, no less than 1.4mg.
Claims (6)
1. a kind of preparation method for the Chinese medicine composition for treating gastritis, the Chinese medicine composition is former by the Chinese medicine of following weight proportion
Material medicine is prepared,
It is characterized in that, steps are as follows for the preparation method:
The above-mentioned parts by weight of lily, Radix Notoginseng, endothelium corneum gigeriae galli, cattail pollen, rhizoma corydalis, acorus graminens soland, Poria cocos, rhizoma alismatis, 20%-100% it is white
Nine taste medicinal powder of Chinese herbaceous peony is broken into 80-200 mesh powder；Remaining flavour of a drug add water to cook 2-4 times, 0.5-3 hours each, and it is dense to merge medical fluid filtration
It is reduced to the dilute cream of relative density 1.10-1.20, ethyl alcohol, which is added, makes alcohol content up to 50-80%, stands 1-5 days；Ethanol recycles second
Alcohol, the medicinal extract for being concentrated into relative density to 1.10-1.50；Powder mixes with medicinal extract, obtains pharmaceutically active substance, by preparation side
Method is prepared into pharmaceutical preparations composition.
2. preparation method according to claim 1, which is characterized in that the Chinese medicine composition is by following weight proportion
Medicine bulk pharmaceutical chemicals are prepared,
It is characterized in that, steps are as follows for the preparation method:
The above-mentioned parts by weight of lily, Radix Notoginseng, endothelium corneum gigeriae galli, cattail pollen, rhizoma corydalis, acorus graminens soland, Poria cocos, rhizoma alismatis, 20%-100% it is white
Nine taste medicinal powder of Chinese herbaceous peony is broken into 100 mesh powder；Remaining flavour of a drug add water to cook 3 times, 2 hours every time, merge medical fluid filtration and are concentrated into relatively
The dilute cream of density 1.10-1.20, ethyl alcohol, which is added, makes alcohol content up to 65%, stands 3 days；Ethanol recycling ethyl alcohol is concentrated into relatively
Density to 1.10-1.50 medicinal extract；Powder mixes with medicinal extract, obtains pharmaceutically active substance, by formulation method, is prepared into drug
Preparation compositions.
3. preparation method according to claim 1, which is characterized in that the Chinese medicine composition is by following weight proportion
Medicine bulk pharmaceutical chemicals are prepared,
It is characterized in that, steps are as follows for the preparation method:
The above-mentioned parts by weight of lily, Radix Notoginseng, endothelium corneum gigeriae galli, cattail pollen, rhizoma corydalis, acorus graminens soland, Poria cocos, rhizoma alismatis, 20%-100% it is white
Nine taste medicinal powder of Chinese herbaceous peony is broken into 100 mesh powder；Remaining flavour of a drug add water to cook 3 times, 2 hours every time, merge medical fluid filtration and are concentrated into relatively
The dilute cream of density 1.10-1.20, ethyl alcohol, which is added, makes alcohol content up to 65%, stands 3 days；Ethanol recycling ethyl alcohol is concentrated into relatively
Density to 1.10-1.50 medicinal extract；Powder mixes with medicinal extract, obtains pharmaceutically active substance, and condensed pill is made in pill, drying；Or
Powder is mixed with medicinal extract, is pelletized, capsule or tablet is made in drying；Or powder is mixed with medicinal extract, dries, is crushed, medicine after crushing
Every 1 parts by weight of powder add 0.6-1.5 parts by weight refined honey that concentration honeyed bolus is made.
4. preparation method according to claim 1, which is characterized in that the Chinese medicine composition is condensed pill.
5. preparation method according to claim 1, which is characterized in that the Chinese medicine composition is capsule.
6. preparation method according to claim 1, which is characterized in that the Chinese medicine composition is tablet.
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| 正交试验法优选摩罗片的提取工艺;高立霞 等;《泰山医学院学报》;20090125;第30卷(第1期);第32-34页 |
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Denomination of invention: A preparation method and preparation of traditional Chinese medicine composition for treating gastritis Effective date of registration: 20220225 Granted publication date: 20190628 Pledgee: China Construction Bank Corporation Handan Fudong sub branch Pledgor: HANDAN PHARMACEUTICAL Co.,Ltd. Registration number: Y2022130000009 |
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Denomination of invention: A method and preparation of a traditional Chinese medicine combination for treating gastritis Granted publication date: 20190628 Pledgee: China Construction Bank Corporation Handan Fudong sub branch Pledgor: HANDAN PHARMACEUTICAL Co.,Ltd. Registration number: Y2024980006897 |