CN105380790B - A method of determining closed disjunctor boiling machine Herb-decocting Method amount of water - Google Patents
A method of determining closed disjunctor boiling machine Herb-decocting Method amount of water Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61J2200/30—Compliance analysis for taking medication
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Abstract
The present invention discloses a kind of method for determining closed disjunctor boiling machine Herb-decocting Method amount of water, and this method comprises the following steps: (1) determining the water absorption rate and dosage of each taste prepared slices of Chinese crude drugs in Chinese prescription；(2) determine that decoction needs liquid volume to be achieved；(3) water for decocting and needing to be added: amount of water=evaporation capacity+liquid volume-correction coefficient × Chinese prescription total weight+∑ (water absorption rate × dosages of the prepared slices of Chinese crude drugs) is calculated as follows.Using method of the invention, quality of boiling medicine can be ensured, fried expected liquid volume, had both guaranteed the compliance and clinical efficacy of patient's medication, and be also avoided that unnecessary waste as required.
Description
Technical field
The present invention relates to a kind of methods for determining closed disjunctor boiling machine Herb-decocting Method amount of water.
Background technique
In application boiling machine decoction process, amount of water is the no small problem that puzzlement decocts, random very strong, this
It may influence the quality boiled medicine, it is also difficult to filling suitable liquid volume out.It is fried suitable as required in order to ensure quality of boiling medicine
Liquid volume, both guaranteed patient medication compliance and clinical efficacy, be also avoided that unnecessary waste.
Summary of the invention
The technical problem to be solved by the present invention is to overcome the existing defects, and it is pan-fried to provide a kind of closed disjunctor boiling machine of determination
The method for boiling traditional Chinese herbal decoction amount of water.
In order to solve the above-mentioned technical problems, the present invention provides the following technical solutions:
A method of it determining closed disjunctor boiling machine Herb-decocting Method amount of water, includes the following steps:
(1) water absorption rate and dosage of each taste prepared slices of Chinese crude drugs in Chinese prescription are determined；
(2) determine that decoction needs liquid volume to be achieved；
(3) water for decocting and needing to be added is calculated as follows:
Amount of water=evaporation capacity+liquid volume-correction coefficient × Chinese prescription total weight+∑ (water absorption rate of the prepared slices of Chinese crude drugs
× dosage).
Further, closed disjunctor boiling machine is using electric boiling machine, evaporation capacity=0.1727 × liquid volume -1.2553, correction
Coefficient is 0.40.
Further, closed disjunctor boiling machine uses combustion gas boiling machine, evaporation capacity=0.0846 × liquid volume+15.316, school
Positive coefficient is 0.45.
Further, the evaluation method of prepared slices of Chinese crude drugs water absorption rate:
(1) the total sample of the prepared slices of Chinese crude drugs is obtained；
(2) using the density of the prepared slices of Chinese crude drugs, shape and moisture as index, Q type is carried out to the total sample of the prepared slices of Chinese crude drugs of step (1)
Clustering；
(3) it chooses frequency of use in total sample and measures the water absorption rate of each prepared slices of Chinese crude drugs up to 10% or more the prepared slices of Chinese crude drugs；
(4) cluster analysis result for combining step (2) calculates step (3) and gathers for the mean water absorption of a kind of prepared slices of Chinese crude drugs
Rate, the mean water absorption rate are the water absorption rate of other prepared slices of Chinese crude drugs in such.
Further, classification number is 10.
Using method of the invention, quality of boiling medicine can be ensured, fried expected liquid volume, had both guaranteed that patient took as required
The compliance and clinical efficacy of medicine, are also avoided that unnecessary waste.
Specific embodiment
Hereinafter, preferred embodiments of the present invention will be described, it should be understood that preferred embodiment described herein is only used
In the description and interpretation present invention, it is not intended to limit the present invention.
Closed disjunctor boiling machine (natural gas boiling machine: model KR-101N, Koryo Industries, Ltd, South Korea；Electricity is boiled medicine
Machine: model MF-304, Koryo Industries, Ltd, South Korea), the prepared slices of Chinese crude drugs (Xinjiang Zycon Ha Bowei medicine limited liability company), electricity
Sub- scale one (Guangdong Xiangshan Weighing Group Co).
(1) measurement of closed disjunctor boiling machine evaporation capacity
Select electric boiling machine, natural gas boiling machine each one tested, since such boiling machine is in closed environment
Lower progress, the interference of outside environmental elements can be excluded, evaporation capacity is primarily referred to as squeezing the vapor generated when tapping.Pass through
Electricity consumption boiling machine 115 DEG C of temperature display or so (air pressure >=0.1MPa), extrudes water to the tap water heating 30min of various dose,
It is measured with graduated cylinder, calculates evaporation capacity, evaporation capacity=amount of water-surplus；25min is heated when with natural gas boiling machine, temperature is aobvious
Show 115 DEG C or so (air pressures >=0.1MPa), evaporation capacity (being shown in Table 1) is calculated using same method.
1 evaporation capacity tables of data of table
Using surplus as abscissa, evaporation capacity is ordinate, draws standard curve, and electric boiling machine evaporation capacity regression equation is
Y=0.1727x -1.2553 (r=0.9619)；Natural gas boiling machine evaporation capacity regression equation is Y=0.0846x+15.316 (r
=0.9946).
(2) measurement of prepared slices of Chinese crude drugs water absorption rate
Under the work shape of decoction room practical operation, selection natural gas boiling machine carries out the selected representative prepared slices of Chinese crude drugs pan-fried
Experiment is boiled, its water absorption rate is calculated.Every taste crude drug weighs 300g (marking its quality is A), and 8 times of amounts (2400ml) of its quality are added
Water, after impregnating 30 minutes, the closing that is powered decocts 25min, and weighing and squeezing out the quality of the crude drug of liquid after decocting is B.Every taste is raw
Medicine inspection is surveyed 2 times (if data difference can detect 1 time greatly very much again), is averaged.Medicine materical crude slice water absorption=B-A, water absorption rate=(B-A)
× 100%/A.
It randomly selects 2011 to the 2012 annual prescriptions 20000 in the hospital of traditional Chinese hospital, autonomous region to open, uses data analysis application
Weka data mining software (herbal pharmacology room at Institute Of Chinese Materia Medica Of China Academy of Chinese Medical Sciences's scientific research and education) divides from prescription data
Analyse the medicine frequency of Chinese medicine in clinical prescription.The plant of medicine frequency >=10% is chosen from the hospital of traditional Chinese hospital, autonomous region outpatient service prescription
Medicine, mineral drug, animal drugs carry out water absorption rate measurement experiment as representative medicine materical crude slice, the results are shown in Table 2-1 and table 2-2.
22 kinds of representative prepared slices of Chinese crude drugs water absorption rate measurement result tables selected by table 2-1
22 kinds of representative prepared slices of Chinese crude drugs water absorption rate measurement result tables selected by table 2-2
Measuring the water absorption rates of all prepared slices of Chinese crude drugs used, then time-consuming, heavy workload, and close with prepared slices of Chinese crude drugs water absorption rate
Relevant property is cut, is easier to measure if the density of medicine materical crude slice, shape, moisture content index.Since types of herbal Yinpian prepared for decoction is more, if directly
It connects and the water absorption rate of every taste prepared slices of Chinese crude drugs is measured, then heavy workload, inefficient.This experiment utilizes the layer in clustering
Secondary cluster, using the property closely related with prepared slices of Chinese crude drugs water absorption rate as judge index, such as the density of medicine materical crude slice, shape, moisture compared with
Easily measure index；Hierarchical cluster cluster is carried out to 388 kinds of prepared slices of Chinese crude drugs, so that the similar medicine materical crude slice of water suction property gathers for one kind, benefit
Its water absorption rate is represented with a close average value in above-mentioned 22 kinds representative prepared slices of Chinese crude drugs cluster results.If gathered for a kind of medicine
There is water absorption rate difference biggish between material medicine materical crude slice, can be finely adjusted, can not only reduce workload in this way, but also liquid volume added number can be made
It learns model formation to be simplified, convenience of calculation.In this way if it is a kind of newly into the prepared slices of Chinese crude drugs measure its density, shape, moisture etc.
Index judges which kind of it belongs to according to cluster result, then which kind of mean water absorption rate its water absorption rate just use.Hierarchical cluster
Method selection sample clustering (Q type), using Euclidean distance square as measure, Word method is as clustering method.Selection is solidifying
Poly- state table, which generates, clusters tree-like chart.Clustering data result is as shown in table 3.It is polynary gradually using the progress of water absorption rate inverse
It returns, using medicinal material density, medicinal material shape, it is index that medicinal material moisture intersects respectively, is fitted multiple linear regression equations, wherein R
=0.9118, AIC=76, BIC=72.4 are corrected, the water absorption rate of every kind of prepared slices of Chinese crude drugs is predicted using regression equation, is conveniently used for
Judge prepared slices of Chinese crude drugs cluster result, observation gathers the water absorption rate between a kind of prepared slices of Chinese crude drugs and differs size, thus determines cluster numbers.
The cluster result (22 kinds therein) of 3 prepared slices of Chinese crude drugs of table
Therefore, 388 kinds of prepared slices of Chinese crude drugs are divided by 10 classes using above-mentioned clustering method herein, the corresponding prepared slices of Chinese crude drugs are inhaled
Water rate is respectively the 1st class: 158%, the 2nd class 167%, and the 3rd class 150%, the 4th class 120%, the 5th class 130%, the 6th class
110%, the 7th class 25%, the 8th class 78%, the 9th class 33%, the 10th class 8%.
(3) the squeeze function parameter correction of different type boiling machine
Electric boiling machine discharge medical fluid is to exclude medical fluid by the air pressure that its steam is formed inside boiling machine, and natural gas
Boiling machine discharge medical fluid is the air pressure and artificial rotary squeezing bar increasing action power formed inside boiling machine by its steam
Medical fluid is discharged, the extrusion principle of different type boiling machine is different, and different type boiling machine pair will be indicated using squeezing parameter
The squeeze function of prescriptions of traditional Chinese medicine, to the squeeze function of prescriptions of traditional Chinese medicine when further studying different type boiling machine Herb-decocting Method
It is whether related with prescriptions of traditional Chinese medicine Chinese medicine total weight, therefore 22 prescriptions of traditional Chinese medicine are selected, it is utilized respectively electric boiling machine and natural gas
Boiling machine carries out decocting herb medicine materical crude slice, and weighing same prescription respectively, it squeezes medicinal material total weight after preceding medicinal material total weight and extruding,
Data are recorded, are calculated by the calculation method of squeeze function parameter: squeeze function parameter=(medicinal material total weight-extruding before squeezing
Medicinal material total weight afterwards) × 100%/medicinal material total weight after squeezing, as shown in table 4-1, table 4-2.Such as 5 institute of table before and after parameter correction
Show.
Table 4-1 squeeze function parametric data table
Table 4-2 squeeze function parametric data table
Contrast table before and after 5 parameter correction of table
(4) foundation of mathematical model and confirmatory experiment
For variety classes boiling machine, the Accuracy Verification for randomly selecting 44 prepared slices of Chinese crude drugs prescriptions progress formula is (electric to decoct
Medicine machine and natural gas boiling machine respectively select 22 prescriptions), actual operation demonstration is carried out in decoction room.Process is as follows:
(a) according to prescription and to 388 kinds of prepared slices of Chinese crude drugs be divided into 10 classes as a result, determining each taste prepared slices of Chinese crude drugs in prescription
Dosage and water absorption rate, as a result such as table 6- table 17:
The electric boiling machine of table 6 decocts prescription 1-4
The electric boiling machine of table 7 decocts prescription 5-8
The electric boiling machine of table 8 decocts prescription 9-12
The electric boiling machine of table 9 decocts prescription 13-16
The electric boiling machine of table 10 decocts prescription 17-20
The electric boiling machine of table 11 decocts prescription 21-22
12 natural gas boiling machine of table decocts prescription 1-4
13 natural gas boiling machine of table decocts prescription 5-8
14 natural gas boiling machine of table decocts prescription 9-12
15 natural gas boiling machine of table decocts prescription 13-16
16 natural gas boiling machine of table decocts prescription 17-20
17 natural gas boiling machine of table decocts prescription 21-22
(b) determine that decoction needs liquid volume (namely standard volume) to be achieved；
(c) water for decocting and needing to be added is calculated as follows:
Amount of water=evaporation capacity+liquid volume-correction coefficient × Chinese prescription total weight+∑ (water absorption rate of the prepared slices of Chinese crude drugs
× dosage).
When wherein, using electric boiling machine, evaporation capacity=0.1727 × liquid volume -1.2553, correction coefficient 0.40；
When using combustion gas boiling machine, evaporation capacity=0.0846 × liquid volume+15.316, correction coefficient 0.45.
Experimental result is as shown in table 18-1 and table 18-2.
Table 18-1 liquid volume added mathematical model verify data table
Table 18-2 liquid volume added mathematical model verify data table
Finally, it should be noted that the foregoing is only a preferred embodiment of the present invention, it is not intended to restrict the invention,
Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used
To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features.
All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in of the invention
Within protection scope.
Claims (4)
1. a kind of method for determining closed disjunctor boiling machine Herb-decocting Method amount of water, includes the following steps:
(a) water absorption rate and dosage of each taste prepared slices of Chinese crude drugs in Chinese prescription are determined；
(b) determine that decoction needs liquid volume to be achieved；
(c) water for decocting and needing to be added is calculated as follows:
Amount of water=evaporation capacity+liquid volume-correction coefficient × Chinese prescription total weight+∑ (water absorption rate × use of the prepared slices of Chinese crude drugs
Dose)；
The evaluation method of prepared slices of Chinese crude drugs water absorption rate:
(1) the total sample of the prepared slices of Chinese crude drugs is obtained；
(2) using the density of the prepared slices of Chinese crude drugs, size, shape and moisture as index, Q is carried out to the total sample of the prepared slices of Chinese crude drugs of step (1)
Type clustering；
(3) it chooses frequency of use in total sample and measures the water absorption rate of each prepared slices of Chinese crude drugs up to 10% or more the prepared slices of Chinese crude drugs；
(4) cluster analysis result for combining step (2) calculates step (3) and gathers for the mean water absorption rate of a kind of prepared slices of Chinese crude drugs, institute
State the water absorption rate that mean water absorption rate is other prepared slices of Chinese crude drugs in such.
2. determining the method for closed disjunctor boiling machine Herb-decocting Method amount of water according to claim 1, which is characterized in that
Closed disjunctor boiling machine is using electric boiling machine, evaporation capacity=0.1727 × liquid volume -1.2553, correction coefficient 0.40.
3. determining the method for closed disjunctor boiling machine Herb-decocting Method amount of water according to claim 1, which is characterized in that
Closed disjunctor boiling machine uses combustion gas boiling machine, evaporation capacity=0.0846 × liquid volume+15.316, correction coefficient 0.45.
4. determining the method for closed disjunctor boiling machine Herb-decocting Method amount of water according to claim 1, which is characterized in that
The classification number of step (2) clustering is 10.
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| CN106408129B (en) * | 2016-09-28 | 2021-05-07 | 河南中医药大学 | Method for detecting quality of traditional Chinese medicine decoction by relative density |
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