CN105379966A - Water-soluble allicin mixture and preparation method thereof - Google Patents
Water-soluble allicin mixture and preparation method thereof Download PDFInfo
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- CN105379966A CN105379966A CN201510683428.5A CN201510683428A CN105379966A CN 105379966 A CN105379966 A CN 105379966A CN 201510683428 A CN201510683428 A CN 201510683428A CN 105379966 A CN105379966 A CN 105379966A
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Abstract
The invention provides a water-soluble allicin mixture and a preparation method thereof aiming at the defects that allicin cannot be dissolved in water and cannot be fully absorbed conveniently. The original ingredients of allicin are kept and are not damaged, the utilization rate of the allicin is increased, and use by a user is facilitated. The water-soluble allicin mixture is prepared from, by weight, 2-30 parts of allicin, 2-30 parts of emulgator, 0.1-5 parts of mercaptamine and 40-100 parts of water. Mercaptamine is added, and therefore the water-soluble allicin mixture can be stored for a long time without layering. Mercaptamine and allicin generate the synergistic effect.
Description
Technical field
The invention belongs to field of animal feed, be specifically related to a kind of water-soluble allicin mixture and preparation method thereof.
Background technology
Garlic belongs to Liliaceae, and be perennial root herbaceous plant, all have cultivation all over the world, there are long cultivation and applicating history in China.The traditional Chinese medical science is thought that garlic is pungent, warm in nature, can be separated stagnant gas, warming spleen and stomach, eliminating mass are long-pending, removing toxic substances desinsection.
Allicin is extract or the synthetic of garlic, containing abundant Organic nutrient, containing crude protein, fat, crude fibre, full sugar, and a small amount of calcium, phosphorus ore material and thiamine, riboflavin, garlic wet goods.In addition, also containing the mineral matter element such as measurable 17 seed amino acids and potassium, calcium, magnesium, copper, sodium, zinc, manganese, iron, boron.
Disulfide in allicin and trithioether can enter cytoplasm through the cell membrane of germ, are cystine linkage by the oxydasis of hydroxyl, thus the eubolism of T suppression cell division and destruction germ and cancer cell.Allicin can suppress the growth and breeding of shigella dysenteriae, typhoid bacillus, comma bacillus effectively, have staphylococcus, pneumococcus, streptococcus, Aspergillus flavus, aspergillus fumigatus etc. and significantly suppress and killing action, tubercle bacillus, some fungi, protozoon etc. are also had to certain suppression and kill used.Various active material in allicin, makes cellular metabolism strengthen, and vigor improves, and immunity of organisms is strengthened.
Allicin has strong attractant, and garlic oil is a kind of fragrance matter, and most animals such as fish and bird all like this smell, and the sense of smell of allicin energy stimulating animal and the sense of taste, make feed intake improve.In feed, allicin can not add excessive, otherwise causes livestock and poultry search for food excessive and produce indigestion.
Allicin can strengthen the flavor component in broiler chicken, laying hen, in the feed of chicken, add a certain amount of garlic, and the fragrance of chicken can be made to thicken.Method is simple to add garlic in feed, and cost is low, easily promotes, and garlic can be soaked peeling, section, dries (or drying), then pulverize and package spare.
Volatile sulfur compound in allicin, mosquitos and flies worm can be driven suction is stung to feed and ight soil, allicin is transformed under the effect of allicin enzyme in vivo, manure pit is entered after discharging with urine, the breeding of mosquitos and flies in fecaluria and the growth of larva can be stoped, reduce mosquitos and flies to the harassing and wrecking of animal, reduce transmission, improve surrounding environment.
Allicin can strengthen animal gastric secretion, gastrointestinal peristalsis, the appetite of stimulating animal, promotes alimentary canal absorbing nutriment, has obvious growth promoting function to animal, improves daily gain, improves the price of deed, improves the utilization rate of feed.
Allicin is a kind of multifunctional feed additive that development in recent years is got up, with its effect extensively, Be very effective, noresidue, without the resistance to the action of a drug, without three-induced effect, low cost and the advantage and enjoy the favor of raiser and feed producer such as to stimulate appetite.But conventional allicin can not be water-soluble, present that utilization rate is low is not easy to the defects such as animal fully absorbs in actual use.
Summary of the invention
Can not be water-soluble for allicin, be not easy to the defect fully absorbed, the invention provides a kind of water-soluble allicin mixture and preparation method thereof, both remained the not destroyed utilization rate turn improving allicin of original composition of allicin, and be user-friendly to.
According to the first embodiment of the present invention, provide a kind of water-soluble allicin mixture (also referred to as allicin emulsion):
Water-soluble allicin mixture, comprises following component or composed of the following components:
Allicin: 2-30 weight portion; Preferred 5-20 weight portion, more preferably 8-15 weight portion, further preferred 10-12 weight portion;
Emulsifying agent: 2-30 weight portion, preferred 5-20 weight portion, more preferably 8-15 weight portion, further preferred 10-12 weight portion;
Mercaptamine: 0.1-5 weight portion, preferred 0.2-3 weight portion, more preferably 0.3-1 weight portion, further preferred 0.4-0.8 weight portion;
Water: 40-100 weight portion, preferred 60-90 weight portion, more preferably 70-85 weight portion, further preferred 75-80 weight portion.
In the present invention, for the sucrose fatty acid ester of single acid esters, diacid fat, three sour fat, isobutyric acid acetic acid Sucrose Fatty Acid Ester, the sorbitol anhydride fatty acid fat of mono laurate fat, single palmitin, monostearate, single olein, sodium alginate, the hydrophilies such as alginic acid the third two fat or lipophile stationary value (HLB), in any one of 1-18, also can be the blended emulsifiers of above-mentioned several emulsifying agent composition; Preferred emulsifier is Tween-80.
According to the second embodiment provided by the invention, provide a kind of preparation method of water-soluble allicin mixture:
Prepare a method for water-soluble allicin mixture, comprise the following steps:
(1) by Mercaptamine dissolved water, the aqueous solution being dissolved with Mercaptamine is obtained;
(2) allicin is mixed in a reservoir with emulsifying agent, stir, obtain the mixture of allicin and emulsifying agent;
(3) aqueous solution being dissolved with Mercaptamine is placed in reactor, under agitation slowly adds the mixture of allicin and emulsifying agent, add rear abundant stirring.
In first scheme:
Allicin: 2-30 weight portion; Preferred 5-20 weight portion, more preferably 8-15 weight portion, further preferred 10-12 weight portion;
Emulsifying agent: 2-30 weight portion, preferred 5-20 weight portion, more preferably 8-15 weight portion, further preferred 10-12 weight portion;
Mercaptamine: 0.1-5 weight portion, preferred 0.2-3 weight portion, more preferably 0.3-1 weight portion, further preferred 0.4-0.8 weight portion;
Water: 40-100 weight portion, preferred 60-90 weight portion, more preferably 70-85 weight portion, further preferred 75-80 weight portion.
In first scheme, emulsifying agent is the sucrose fatty acid ester of single acid esters, diacid fat, three sour fat, isobutyric acid acetic acid Sucrose Fatty Acid Ester, the sorbitol anhydride fatty acid fat of mono laurate fat, single palmitin, monostearate, single olein, sodium alginate, the hydrophilies such as alginic acid the third two fat or lipophile stationary value (HLB), in any one of 1-18, also can be the blended emulsifiers of above-mentioned several emulsifying agent composition; Preferred emulsifier is Tween-80.
As preferably, the mixing time of step (3) is 0.5-3h, preferred 1-2h.
According to the third embodiment provided by the invention, provide the application of a kind of water-soluble allicin mixture in feed:
Water-soluble allicin mixture of the present invention is added in animal feed.
As preferably, the amount adding water-soluble allicin mixture in every 1Kg feed is: 10mg-2000mg, preferred 20mg-1000mg, more preferably 30mg-800mg.
Natural allicin (oil) can adopt the method such as vapor distillation method, organic solvent extraction to extract, interior containing 16 kinds of sulfur-containing compounds, what wherein content was higher is propyl disulfide propylene (about 60%), diallyl disulfide (23% ~ 39%), trisulfides two propylene (13% ~ 19%) and methyl curing propylene etc.
The allicin of synthesis is primarily of diallyl one thioether, disulfide, trithioether (Allicin), four thioether compositions.One thioether has good result in the control of cardio-cerebrovascular diseases, and disulfide, trithioether stable in properties, sterilizing ability are strong.Four thioethers are unstable, are long placed in and can discharge sulphur and other not clear material.One thioether is colourless liquid, boiling point 139 DEG C; Disulfide is colourless to light yellow liquid, has special garlic flavour, water insoluble, is dissolved in the organic solvents such as ethanol, boiling point 139 ~ 139 DEG C; Trithioether is colourless to light yellow liquid, boiling point 139 ~ 140 DEG C; Four thioethers be light brown to brownish red, boiling point 140 DEG C.
Tween 80 (Tween80; Polysorbate80; Polyoxyethy-lene-sorbitan-20-monooleate) have another name called polyoxyethylene sorbitan monoleate, chemistry Tween 80 by name, for faint yellow to orange-yellow thick liquid.Soluble in water, methyl alcohol, ethanol and ethyl acetate, soluble,very slightly in mineral oil, belongs to hydrophilic non-ionic surface active agent, is one of auxiliary material conventional in pharmaceutical preparation.
Mercaptamine is extensively present in animal vegetable tissue, and cysteamine is the part of coacetylase, can participate in sugar in body, fat and protein metabolism, participate in synthetic hormone and neurotransmitter, participate in liver detoxification; Mercaptamine consumes growth hormone release inhibiting hormone, improves level of growth hormone, and stimulating animal grows, and improves reproductive performance, improves carcass quality, reduces food consumption; Mercaptamine is the raw material of synthesizing taurine in vivo, and taurine is essential nutrients and cell-protecting, and it has the cardiovascular and central nervous system disease of protection animal, safeguards the effect of vision, immune system and reproductive system normal function.
In the present invention, utilize the antioxidation of Mercaptamine, allicin forms water soluble mixt under the effect of emulsifying agent, adds Mercaptamine, the preservation that water-soluble allicin mixture can be made more permanent and not stratified; Meanwhile, add Mercaptamine, can promote that animal is to the absorption of water-soluble allicin, thus animal better absorbs, utilizes the effect of allicin and Mercaptamine, produce synergy.
Allicin in the present invention, also referred to as garlic oil, is same substance.All substances of the present invention and equipment all have commercially available.
Compared with prior art, the present invention has following beneficial effect:
1, the carrier of Common garlic element pulvis is generally the solids such as zeolite powder, and carrier and the solvent of the water-soluble allicin mixture of the present invention are water, and water-soluble allicin mixture can be absorbed by animal completely, and the absorptivity of common allicin animal can be much lower.
2, allicin dissolves in ethanol, ether and benzene, but ethanol, ether and stupid equal solvent are unsuitable for animal feed, the present invention is adopted as the sucrose fatty acid ester of single acid esters, diacid fat, three sour fat, isobutyric acid acetic acid Sucrose Fatty Acid Ester, the sorbitol anhydride fatty acid fat of mono laurate fat, single palmitin, monostearate, single olein, sodium alginate, the hydrophilies such as alginic acid the third two fat or lipophile stationary value (HLB), in any one of 1-18, also can be the blended emulsifiers of above-mentioned several emulsifying agent composition; These emulsifying agents itself can the adding ingredient of animal feed, and these emulsifying agents have the effect of well dispersion and emulsification to garlic, make allicin form liquid state.Especially Tween-80, Tween 80 has good emulsifying effectiveness, and the material of certain biology and pharmacologically active, can play synergy with allicin.
3, add Mercaptamine in the present invention, the preservation that water-soluble allicin mixture (emulsion) can be made more permanent and not stratified, be not separated, it and emulsifying agent (especially Tween 80) improve emulsifying effectiveness jointly; In long storage process, also prevent that allicin is oxidized, sex change simultaneously; In addition, Mercaptamine and allicin produce and act synergistically, and as the synergist of allicin, improve the health of pig and guarantee the healthy growth of porkling.
4, the present invention adopts water as solvent, and safely, reliably, animal itself needs moisture to supplement, and animal, while absorption water, absorbs water-soluble allicin mixture; Also can water-soluble allicin be mixed in animal feed, nutrition purposes, especially for feeding animals together.
5, present invention process is simple, and successful is easy to operate.
Detailed description of the invention
According to the first embodiment of the present invention, provide a kind of water-soluble allicin mixture:
Water-soluble allicin mixture, comprises following component:
Allicin: 2-30 weight portion; Preferred 5-20 weight portion, more preferably 8-15 weight portion, further preferred 10-12 weight portion;
Emulsifying agent: 2-30 weight portion, preferred 5-20 weight portion, more preferably 8-15 weight portion, further preferred 10-12 weight portion;
Mercaptamine: 0.1-5 weight portion, preferred 0.2-3 weight portion, more preferably 0.3-1 weight portion, further preferred 0.4-0.8 weight portion;
Water: 40-100 weight portion, preferred 60-90 weight portion, more preferably 70-85 weight portion, further preferred 75-80 weight portion.
In the present invention, for the sucrose fatty acid ester of single acid esters, diacid fat, three sour fat, isobutyric acid acetic acid Sucrose Fatty Acid Ester, the sorbitol anhydride fatty acid fat of mono laurate fat, single palmitin, monostearate, single olein, sodium alginate, the hydrophilies such as alginic acid the third two fat or lipophile stationary value (HLB), in any one of 1-18, also can be the blended emulsifiers of above-mentioned several emulsifying agent composition; Preferred emulsifier is Tween-80.
According to the second embodiment provided by the invention, provide a kind of preparation method of water-soluble allicin mixture:
Prepare a method for water-soluble allicin mixture, comprise the following steps:
(1) by Mercaptamine dissolved water, the aqueous solution being dissolved with Mercaptamine is obtained;
(2) allicin is mixed in a reservoir with emulsifying agent, stir, obtain the mixture of allicin and emulsifying agent;
(3) aqueous solution being dissolved with Mercaptamine is placed in reactor, under agitation slowly adds the mixture of allicin and emulsifying agent, add rear abundant stirring.
In first scheme:
Allicin: 2-30 weight portion; Preferred 5-20 weight portion, more preferably 8-15 weight portion, further preferred 10-12 weight portion;
Emulsifying agent: 2-30 weight portion, preferred 5-20 weight portion, more preferably 8-15 weight portion, further preferred 10-12 weight portion;
Mercaptamine: 0.1-5 weight portion, preferred 0.2-3 weight portion, more preferably 0.3-1 weight portion, further preferred 0.4-0.8 weight portion;
Water: 40-100 weight portion, preferred 60-90 weight portion, more preferably 70-85 weight portion, further preferred 75-80 weight portion.
In first scheme, emulsifying agent is the sucrose fatty acid ester of single acid esters, diacid fat, three sour fat, isobutyric acid acetic acid Sucrose Fatty Acid Ester, the sorbitol anhydride fatty acid fat of mono laurate fat, single palmitin, monostearate, single olein, sodium alginate, the hydrophilies such as alginic acid the third two fat or lipophile stationary value (HLB), in any one of 1-18, also can be the blended emulsifiers of above-mentioned several emulsifying agent composition; Preferred emulsifier is Tween-80.
As preferably, the mixing time of step (3) is 0.5-3h, preferred 1-2h.
According to the third embodiment provided by the invention, provide the application of a kind of water-soluble allicin mixture in feed:
Water-soluble allicin mixture of the present invention is added in animal feed.
As preferably, the amount adding water-soluble allicin mixture in every 1Kg feed is: 10mg-2000mg, preferred 20mg-1000mg, more preferably 30mg-800mg.
Embodiment 1
A kind of water-soluble allicin mixture, preparation method:
(1) Mercaptamine of 0.1 weight portion is dissolved in 95 weight parts waters, obtain the aqueous solution being dissolved with Mercaptamine;
(2) Tween 80 of the allicin of 3 weight portions with 3 weight portions is mixed in a reservoir, stir, obtain the mixture of allicin and emulsifying agent;
(3) aqueous solution being dissolved with Mercaptamine is placed in reactor, under agitation slowly adds the mixture of allicin and emulsifying agent, add rear abundant stirring, stir 1 hour, to homogeneous phase.Obtain water-soluble allicin mixture I.
Embodiment 2
Repeat embodiment 1, just allicin 10 weight portion, 10 weight portion Tween 80s, 0.5 weight portion Mercaptamine, 80 weight parts waters.Obtain water-soluble allicin mixtures II.
Embodiment 3
Repeat embodiment 1, just allicin 20 weight portion, 20 weight portion Tween 80s, 4 weight portion Mercaptamines, 55 weight parts waters.Obtain water-soluble allicin mixtures III.
Comparative example 1
A kind of water-soluble allicin mixture, preparation method:
The Tween 80 of the allicin of 10 weight portions with 10 weight portions is mixed in a reservoir, stirs, obtain the mixture of allicin and emulsifying agent; Obtain mixture IV.
Comparative example 2
The Tween 80 of the allicin of 10 weight portions, 10 weight portions and the origanum oil of 10 weight portions are mixed in a reservoir, stirs, obtain the mixture of allicin and emulsifying agent; Obtain mixture V.
Test method 1
Hold obtaining mixture I-V in above-described embodiment with identical container respectively, place in air, room temperature, observed after a period of time.
Table 1
As can be seen from Table 1, the mixture not adding Mercaptamine places layering after month, illustrates that this mixture can not keep homogeneous phase for a long time; Place after two months, there is no the smell of allicin, illustrate that this allicin is oxidized, lose the function of allicin.Do not add Mercaptamine, add the mixture of origanum oil can place two months not stratified, also there is the smell of allicin, but can not place longer time.And water-soluble allicin mixture of the present invention can be preserved for a long time, not stratified, the not oxidized Sum decomposition of allicin, still can keep the existing forms of allicin.
Test method 2
Get 5 tons of piglet feeds, be divided into equal 5 parts, in a foddering, add 500g mixture I, be numbered feed I; In second part of feed, add 500g mixtures II, be numbered Feed II; In the 3rd part of feed, add 500g mixtures III, be numbered Feed II I; In the 4th part of feed, add 500g mixture IV, be numbered feed IV; In the 5th part of feed, add 500g mixture V, be numbered feed V.
Commercially available piglet 50, about body weight 20Kg, healthy, be divided into five groups at random, often organize 10.
Piglet is placed same place to feed, point 5 pig houses.According to daily nursing, free choice feeding and drinking-water.
Test period: 1 month
Experimental result:
Table 2
| Feed I | Feed II | Feed II I | Feed IV | Feed V | |
| Head number (head) | 10 | 10 | 10 | 10 | 10 |
| Preliminary examination head counterpoise (Kg) | 20.12 | 20.18 | 19.95 | 20.01 | 20.07 |
| Examination head counterpoise (Kg) eventually | 49.6 | 52.7 | 48.3 | 42.0 | 43.2 |
| Health status | Healthy | Healthy | Healthy | Healthy | Healthy |
As can be seen from Table 2, the growth effect of water-soluble allicin of the present invention to piglet is better than feed IV, the feed V growth effect to piglet, and all can ensure the health of pig.
Claims (10)
1. a water-soluble allicin mixture, comprises following component:
Allicin: 2-30 weight portion;
Emulsifying agent: 2-30 weight portion
Mercaptamine: 0.1-5 weight portion
Water: 40-100 weight portion.
2. mixture according to claim 1, is characterized in that:
Allicin: 5-20 weight portion
Emulsifying agent: 5-20 weight portion
Mercaptamine: 0.2-3 weight portion
Water: 60-90 weight portion.
3. mixture according to claim 1, is characterized in that:
Allicin: 8-15 weight portion
Emulsifying agent: 8-15 weight portion
Mercaptamine: 0.3-1 weight portion
Water: 70-85 weight portion.
4. the water-soluble allicin mixture according to any one of claim 1-3, it is characterized in that: described emulsifying agent is the sucrose fatty acid ester of single acid esters, diacid fat, three sour fat, isobutyric acid acetic acid Sucrose Fatty Acid Ester, the sorbitol anhydride fatty acid fat of mono laurate fat, single palmitin, monostearate, single olein, sodium alginate, the hydrophilies such as alginic acid the third two fat or lipophile stationary value (HLB), in any one of 1-18, also can be the blended emulsifiers of above-mentioned several emulsifying agent composition; Preferred emulsifier is Tween-80.
5. prepare the method for water-soluble allicin mixture or prepare a method for mixture described in claim 1-4, comprising the following steps:
(1) by Mercaptamine dissolved water, the aqueous solution being dissolved with Mercaptamine is obtained;
(2) allicin is mixed in a reservoir with emulsifying agent, stir, obtain the mixture of allicin and emulsifying agent;
(3) aqueous solution being dissolved with Mercaptamine is placed in reactor, under agitation slowly adds the mixture of allicin and emulsifying agent, add rear abundant stirring.
6. method according to claim 5, is characterized in that: the addition of each component is:
Allicin: 2-30 weight portion; Preferred 5-20 weight portion, more preferably 8-15 weight portion
Emulsifying agent: 2-30 weight portion, preferred 5-20 weight portion, more preferably 8-15 weight portion
Mercaptamine: 0.1-5 weight portion, preferred 0.2-3 weight portion, more preferably 0.3-1 weight portion
Water: 40-100 weight portion, preferred 60-90 weight portion, more preferably 70-85 weight portion.
7. the method according to claim 5 or 6, it is characterized in that: described emulsifying agent is the sucrose fatty acid ester of single acid esters, diacid fat, three sour fat, isobutyric acid acetic acid Sucrose Fatty Acid Ester, the sorbitol anhydride fatty acid fat of mono laurate fat, single palmitin, monostearate, single olein, sodium alginate, the hydrophilies such as alginic acid the third two fat or lipophile stationary value (HLB), in any one of 1-18, also can be the blended emulsifiers of above-mentioned several emulsifying agent composition; Preferred emulsifier is Tween-80.
8. the method according to any one of claim 5-7, is characterized in that: the mixing time of step (3) is 0.5-3h, preferred 1-2h.
9. the mixture according to any one of claim 1-4 or the mixture any one of claim 5-8 prepared by method are used for the purposes in feed, it is characterized in that: added in animal feed by water-soluble allicin mixture.
10. purposes according to claim 9, is characterized in that: the amount adding water-soluble allicin mixture in every 1Kg feed is: 10mg-2000mg, preferred 20mg-1000mg, more preferably 30mg-800mg.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107890564A (en) * | 2017-06-12 | 2018-04-10 | 揭阳市润达肠衣有限公司 | A kind of compounding aqueous emulsion containing allicin and liposoluble vitamin and preparation method thereof |
| CN109430687A (en) * | 2018-12-13 | 2019-03-08 | 江南大学 | A kind of composition can be used as aflatoxin scavenger |
| CN115887451A (en) * | 2023-01-05 | 2023-04-04 | 山东国邦药业有限公司 | Levamisole hydrochloride tablet and preparation method thereof |
| CN117379373A (en) * | 2023-09-28 | 2024-01-12 | 石家庄正大鸿福牧业有限公司 | Compound aqueous emulsion of garlic oil and carvacrol with homogeneous phase stability and preparation method thereof |
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| CN107890564A (en) * | 2017-06-12 | 2018-04-10 | 揭阳市润达肠衣有限公司 | A kind of compounding aqueous emulsion containing allicin and liposoluble vitamin and preparation method thereof |
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| CN115887451A (en) * | 2023-01-05 | 2023-04-04 | 山东国邦药业有限公司 | Levamisole hydrochloride tablet and preparation method thereof |
| CN117379373A (en) * | 2023-09-28 | 2024-01-12 | 石家庄正大鸿福牧业有限公司 | Compound aqueous emulsion of garlic oil and carvacrol with homogeneous phase stability and preparation method thereof |
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| CN105379966B (en) | 2017-06-27 |
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