CN105353096A - Apparatus for determining needle passing performance of injection - Google Patents
Apparatus for determining needle passing performance of injection Download PDFInfo
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- CN105353096A CN105353096A CN201510670937.4A CN201510670937A CN105353096A CN 105353096 A CN105353096 A CN 105353096A CN 201510670937 A CN201510670937 A CN 201510670937A CN 105353096 A CN105353096 A CN 105353096A
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- syringe
- injection
- counterweight
- syringeability
- support
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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- Chemical & Material Sciences (AREA)
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- Food Science & Technology (AREA)
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- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
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- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses an apparatus for determining the needle passing performance of an injection. The apparatus comprises a counterweight, a syringe, a support and a timer, wherein the counterweight is arranged on a piston handle of the syringe through a counterweight sleeve box, and the needle cylinder of the syringe is fixed by the support. The invention also provides a set for determining the needle passing performance of the injection. The set comprises the apparatus for determining the needle passing performance of the injection and an auxiliary device, wherein the auxiliary device is a collection container. In use of the apparatus, the counterweight provides a constant heavy load to the piston of the syringe to push quantitative liquid to flow out from the syringe, and the timer meters time when a certain amount of the medicinal liquid flows out, so the needle passing performance of the medicinal liquid can be determined; and the apparatus avoids errors caused artificial factors during detection of the needle passing performance through hand-operated pushing and injection, so measurement results are more accurate.
Description
Technical field
The present invention relates to a kind of device measuring injection syringeability, belong to medicine and vaccine research and development and quality assessment field.
Background technology
Syringeability evaluates liquid or the vaccine index by entry needle complexity.It is the important indicator that drug injection and injection vaccine quality are evaluated that syringeability detects.Drug injection and injection vaccine are the formulations that humans and animals medicine and vaccine are conventional.In drug injection and vaccine development process, and during quality assessment, usually need to measure its syringeability.Good syringeability guarantees medicine and the convenient prerequisite injected in humans and animals body of vaccine.Syringeability as drug injection or injection vaccine is bad, can be very difficult when injecting to human or animal, easily causes injected dose to be forbidden, causes poisoning (during overdose) or invalid (during underdosage).
In report in the past, the manual method of injecting or aspirating of syringeability many employings syringe (being made up of piston handle, piston rod, piston, syringe and syringe needle) of drug injection and injection vaccine is evaluated.Although method of injecting manual is comparatively simple, and because the individual difference of human body is very large, the dynamics of hand is difficult to accurately control, and measured result is difficult to form unified standard, and the result of commensurate's gained is not difficult to compare.
Summary of the invention
The object of this invention is to provide a kind of device measuring injection syringeability, the present invention in use, counterweight provides constant weight to syringe piston, promote liquid quantitative and flow out syringe, the time of a certain amount of liquid outflow is measured with timer, the syringeability of liquid can be judged, present invention, avoiding and manually inject the error that when detecting syringeability, human factor causes, make to record result more accurate.
The device of mensuration injection syringeability provided by the invention, it comprises counterweight, syringe, support and timer;
Described counterweight is located on the piston handle of described syringe by counterweight cover box;
The syringe of described syringe is fixed by support.
In above-mentioned device, described counterweight cover box is fixed or is located at by detachable apparatus on the piston handle of described syringe; Described Weight box is to support and fixing described counterweight, chooses the described Weight box matched with it according to the size of described counterweight.
In above-mentioned device, described support comprises a top board and is attached thereto at least 3 the leg posts connect;
The syringe of described syringe runs through described top board, and the top of the syringe of described syringe or bottom place are connected by retainer plate pad with described top board; Described syringe is fixed, to support the described counterweight on the piston handle of described syringe and described syringe by described support;
The effect of described support is in order to fixing described syringe, is fixed by described syringe perpendicular to surface level.
In above-mentioned device, described support also comprises a base plate;
Described base plate is connected to the bottom of described leg post.
In above-mentioned device, a level meter is set on the described top board of described support;
Bottom margin in the described base plate of described support circumferentially arranges at least 3 foots pad; By described level meter, the equal adjustable-height of described foot pad, to make described support be in water state, then judges whether described support is in horizontality.
In above-mentioned device, described support comprises an iron stand, and described iron stand is furnished with the clip of fixing described syringe.
In above-mentioned device, the material of the syringe of described syringe adopts clear glass or transparent plastic, so that observe the volume of the syringe internal liquid of described syringe;
The syringe of described syringe is provided with scale, so that the volume of trickle in the syringe measuring described syringe;
The syringe needle of described syringe and the syringe of described syringe for removably connecting so that change the syringe needle of described syringe according to the syringeability complexity of liquid to be detected or vaccine.
In above-mentioned device, the quality of described counterweight is 1.0 ~ 4000g; Described counterweight provides constant weight for described syringe;
The volume of the syringe of described syringe is 1.0 ~ 200mL;
Described timer is hand timer or automatic timing unit; Described timer is for observing a certain amount of liquid delivery time.
The above-mentioned application of installation of the present invention is in the syringeability measuring injection;
Described injection is specially drug injection or injection vaccine.
Injection of the present invention is specially ivermectin supensoid agent that sodium carboxymethyl cellulose (CMC-Na) prepared as suspending agent or the ivermectin supensoid agent that carboxymethyl cellulose (CMC) is prepared as suspending agent.
Invention further provides a kind of suit measuring injection syringeability, it comprises device and the auxiliary appliance of described mensuration injection syringeability;
Described auxiliary appliance is collection container; When the present invention uses, described collection container is placed in below the syringe needle of described syringe, to receive the liquid flowed out in described syringe.
In the present invention, described counterweight is placed on syringe piston handle, by its gravity, constant weight is provided to syringe piston, to extrude syringe piston, the liquid in pushing syringe or vaccine flow out from entry needle, carry out timing (with timer) by the time of flowing out liquid or the vaccine of certain volume in syringe, the time length that drug injection or injection vaccine flow out can reflect drug injection or the injection vaccine complexity by entry needle, i.e. syringeability.
The present invention has the following advantages:
1) the present invention in use counterweight provide constant weight to syringe piston, promote liquid and flow out syringe, avoid and manually inject the error that causes of human factor when detecting syringeability, make to record result more accurate.
2) applied widely, can be widely used in humans and animals drug injection, injection vaccine development process and quality assessment time syringeability detect.
3) there is the features such as production is easy, price is more cheap.
Accompanying drawing explanation
Fig. 1 is the device that the present invention measures injection syringeability, and the bottom place of the syringe of described syringe is connected by retainer plate pad with described top board.
Fig. 2 is the device that the present invention measures injection syringeability, and the top place of the syringe of described syringe is connected by retainer plate pad with described top board.
Fig. 3 is the device that the present invention measures injection syringeability, fixes syringe with iron stand.
Fig. 4 is the device of the present invention's difference configuration, and the syringeability of the variable concentrations glycerine of mensuration (time, s).
Fig. 5 is the syringeability of the ivermectin supensoid agent that the sodium carboxymethyl cellulose (CMC-Na) of variable concentrations is prepared as suspending agent.
Fig. 6 is the syringeability of the ivermectin supensoid agent that the carboxymethyl cellulose (CMC) of variable concentrations is prepared as suspending agent.
In Fig. 1-3, mark is as follows: 1 counterweight; 2 counterweight cover boxes; 3 piston handles; 4 syringes with a scale; 5 fixed bolsters; 51 geometrical clamps; 6 level meters; 7 supports; 8 adjustable foots pad; 9 collection containers; 10 syringe needles; 11 iron stands.
Embodiment
The experimental technique used in following embodiment if no special instructions, is conventional method.
Material used in following embodiment, reagent etc., if no special instructions, all can obtain from commercial channels.
Below in conjunction with accompanying drawing, the present invention is further described, but the present invention is not limited to following examples.
The syringeability of the glycerine of embodiment 1, mensuration variable concentrations
The device of the mensuration injection syringeability shown in Fig. 1 of the present invention is used to determine the syringeability of variable concentrations glycerine.Concrete determination step is as follows:
1) by sucking glycerine in syringe, then will be placed on support 7 by fixed bolster 5 bottom the syringe 4 with a scale of syringe, syringe needle 10 is enclosed within syringe 4 with a scale, by the levelness of adjustable foot pad 8 adjusting pole 7, judged by level meter 6, to determine that support 7 is in level;
2) counterweight 1 is put into, when liquid flows out, when opening timer by the counterweight that the piston handle 3 of syringe is arranged cover box 2;
3) collect the glycerine flowed out with collection container 9, observe the state flowed out during the glycerine flowed out in syringe, after outflow, close timer, read the time of timer.
As shown in table 1, with the device of difference configuration, determine the syringeability of variable concentrations glycerine, the broken line graph of result as shown in Figure 4.As can be seen from the test results, the syringeability of the glycerine of variable concentrations is different, even if adopt the device of different configuration to measure, the variation tendency of the glycerine syringeability of variable concentrations is consistent, namely its syringeability curve is parallel, illustrates that the measurement result that the present invention measures the device of injection syringeability is reliable, stable.
The device of table 1 difference configuration, and the syringeability of the variable concentrations glycerine of mensuration (time, s)
Glycerine water solution with 25%, as test sample, measures the syringeability of different syringe needle.The specification of syringe is 10ml, and working volume is 5ml, selects the syringe needle of different size, measures the time of liquid by syringe needle.Measurement result is as shown in table 2.As shown in Table 2, test findings shows, the syringeability of model to glycerite of syringe needle has a significant effect, and along with the increase of syringe needle model, the syringeability of liquid reduces.The selection of the syringe needle 10 that test findings is syringe in apparatus of the present invention provides foundation.
Table 2 different size syringe needle is on the impact of 25% glycerine water solution syringeability
Note: stoste " * " represents that measurement result is excessive, error is very large, is not listed in, and impact is overall.
The syringeability of embodiment 2, mensuration ivermectin supensoid agent
The device of the mensuration injection syringeability shown in Fig. 2 of the present invention is used to determine the syringeability of ivermectin supensoid agent.Concrete determination step is as follows:
1) by sucking ivermectin supensoid agent in syringe, then will be placed on support 7 by fixed bolster 5 bottom the syringe 4 with a scale of syringe, syringe needle 10 is enclosed within syringe 4 with a scale, by the levelness of adjustable foot pad 8 adjusting pole 7, judged by level meter 6, to determine that support 7 is in level;
2) counterweight 1 is put into, when liquid flows out, when opening timer by the counterweight that the piston handle 3 of syringe is arranged cover box 2;
3) collect the ivermectin supensoid agent flowed out with collection container 9, observe the state flowed out during the ivermectin supensoid agent flowed out in syringe, after outflow, close timer, read the time of timer.
With the syringe (working volume is 10ml), 10 of 20ml
#syringe needle and 500g counterweight measure the syringeability of the ivermectin supensoid agent prepared with different suspending agent.As shown in Figure 5, result display is along with the increase of CMC-Na concentration, and the syringeability of ivermectin supensoid agent declines gradually for the syringeability result of the ivermectin supensoid agent prepared as suspending agent with the sodium carboxymethyl cellulose (CMC-Na) of variable concentrations.As shown in Figure 6, result display is along with the increase of CMC concentration, and the syringeability of ivermectin supensoid agent declines gradually for the syringeability result of the ivermectin supensoid agent prepared as suspending agent by the carboxymethyl cellulose (CMC) of variable concentrations.Shown by the above results, apparatus of the present invention effectively can measure the syringeability of different sample.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. measure a device for injection syringeability, it is characterized in that: it comprises counterweight, syringe, support and timer;
Described counterweight is located on the piston handle of described syringe by counterweight cover box;
The syringe of described syringe is fixed by support.
2. device according to claim 1, is characterized in that: described counterweight cover box is fixed or is located at by detachable apparatus on the piston handle of described syringe.
3. device according to claim 1 and 2, is characterized in that: described support comprises a top board and is attached thereto at least 3 the leg posts connect;
The syringe of described syringe runs through described top board, and the top of the syringe of described syringe or bottom place are connected by retainer plate pad with described top board.
4. device according to claim 3, is characterized in that: described support also comprises a base plate;
Described base plate is connected to the bottom of described leg post.
5. the device according to claim 3 or 4, is characterized in that: on the described top board of described support, arrange a level meter;
Bottom margin in the described base plate of described support circumferentially arranges at least 3 foots pad.
6. device according to claim 1 and 2, is characterized in that: described support comprises an iron stand, and described iron stand is furnished with the clip of fixing described syringe.
7. device according to claim 1 and 2, is characterized in that: the material of the syringe of described syringe adopts clear glass or transparent plastic;
The syringe of described syringe is provided with scale;
The syringe needle of described syringe and the syringe of described syringe are for removably connecting.
8. the device according to any one of claim 1-7, is characterized in that: the quality of described counterweight is 1.0 ~ 4000g;
The volume of the syringe of described syringe is 1.0 ~ 200mL;
Described timer is hand timer or automatic timing unit.
9. the device according to any one of claim 1-8 is measuring the application in injection syringeability; Described injection is specially drug injection or injection vaccine.
10. measure a suit for injection syringeability, it is characterized in that: it comprises device according to any one of claim 1-7 and auxiliary appliance;
Described auxiliary appliance is specially collection container.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510670937.4A CN105353096A (en) | 2015-10-13 | 2015-10-13 | Apparatus for determining needle passing performance of injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510670937.4A CN105353096A (en) | 2015-10-13 | 2015-10-13 | Apparatus for determining needle passing performance of injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105353096A true CN105353096A (en) | 2016-02-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510670937.4A Pending CN105353096A (en) | 2015-10-13 | 2015-10-13 | Apparatus for determining needle passing performance of injection |
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| Country | Link |
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| CN (1) | CN105353096A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108593280A (en) * | 2018-06-27 | 2018-09-28 | 上海市医疗器械检测所 | Sliding performance of syringe test device and test method |
| CN112414502A (en) * | 2020-11-10 | 2021-02-26 | 武汉昊诚能源科技有限公司 | Device and method for measuring liquid absorption amount |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86206401U (en) * | 1986-09-01 | 1987-09-16 | 李春来 | Gravity driving device for intravenous injection |
| CN2072406U (en) * | 1990-08-28 | 1991-03-06 | 施晓洲 | Intravenous injection vertical pressure assisting apparatus |
| CN2319060Y (en) * | 1997-12-18 | 1999-05-19 | 陈欢庆 | Constant power intravenous syringe |
| CN2352193Y (en) * | 1998-11-24 | 1999-12-08 | 冯抒云 | Controlled gravity injection means for intravneous injection |
| CN1706391A (en) * | 2005-05-09 | 2005-12-14 | 史同瑞 | Terramycin suspension emulsion |
| CN101862294A (en) * | 2010-06-22 | 2010-10-20 | 华南农业大学 | Ivermectin suspending agent, preparation method and application thereof |
| CN102939121A (en) * | 2010-05-19 | 2013-02-20 | 阿勒根公司 | Modular injection device |
| FR2992562A1 (en) * | 2012-06-27 | 2014-01-03 | Ass Pour Les Transferts De Technologie Du Mans Attm | SYRINGE OF WHICH AT LEAST ONE OF THE PLUG OR BODY IS COATED WITH A HYDROPHILIC PRODUCT. |
| US20150005708A1 (en) * | 2013-06-28 | 2015-01-01 | Juvaplus Sa | Injection device |
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2015
- 2015-10-13 CN CN201510670937.4A patent/CN105353096A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86206401U (en) * | 1986-09-01 | 1987-09-16 | 李春来 | Gravity driving device for intravenous injection |
| CN2072406U (en) * | 1990-08-28 | 1991-03-06 | 施晓洲 | Intravenous injection vertical pressure assisting apparatus |
| CN2319060Y (en) * | 1997-12-18 | 1999-05-19 | 陈欢庆 | Constant power intravenous syringe |
| CN2352193Y (en) * | 1998-11-24 | 1999-12-08 | 冯抒云 | Controlled gravity injection means for intravneous injection |
| CN1706391A (en) * | 2005-05-09 | 2005-12-14 | 史同瑞 | Terramycin suspension emulsion |
| CN102939121A (en) * | 2010-05-19 | 2013-02-20 | 阿勒根公司 | Modular injection device |
| CN101862294A (en) * | 2010-06-22 | 2010-10-20 | 华南农业大学 | Ivermectin suspending agent, preparation method and application thereof |
| FR2992562A1 (en) * | 2012-06-27 | 2014-01-03 | Ass Pour Les Transferts De Technologie Du Mans Attm | SYRINGE OF WHICH AT LEAST ONE OF THE PLUG OR BODY IS COATED WITH A HYDROPHILIC PRODUCT. |
| US20150005708A1 (en) * | 2013-06-28 | 2015-01-01 | Juvaplus Sa | Injection device |
Non-Patent Citations (1)
| Title |
|---|
| YANNIC B.SCHUETZ ET AL.: "A novel thermoresponsive hydrogel based on chitosan", 《EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108593280A (en) * | 2018-06-27 | 2018-09-28 | 上海市医疗器械检测所 | Sliding performance of syringe test device and test method |
| CN112414502A (en) * | 2020-11-10 | 2021-02-26 | 武汉昊诚能源科技有限公司 | Device and method for measuring liquid absorption amount |
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Application publication date: 20160224 |