CN105349831A - Preparation method for medical artificial joint material - Google Patents
Preparation method for medical artificial joint material Download PDFInfo
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- CN105349831A CN105349831A CN201510508671.3A CN201510508671A CN105349831A CN 105349831 A CN105349831 A CN 105349831A CN 201510508671 A CN201510508671 A CN 201510508671A CN 105349831 A CN105349831 A CN 105349831A
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Abstract
The invention discloses a preparation method for a medical artificial joint. According to the alloy material, the medical artificial joint material comprises the following components of 0.2%-1.0% of Nb, 4.5%-6.0% of Cu, 6%-8% of Fe, 6%-7% of Mo, 0.3%-1.0% of Mn, 6%-16% of Zr, 0.5%-0.8% of Ge, 3%-4% of Ga, 2%-4% of Cr, 1%-3% of Ca, 0.1%-0.3% of Mg, 1%-2% of In, less than 0.1% of C and the balance Ti. According to the preparation method for the medical artificial joint material, element powder or alloy powder of all elements with appropriate particle sizes is adopted, after the element powder or the alloy powder is mixed, the element powder or the alloy powder is sintered through injection molding, and accordingly the medical artificial joint is obtained; the strength of the manufactured artificial joint is much larger than that of a medical pure titanium material, the medical artificial joint is friendly to the internal environment of the human body and low in density, and has good smelting and sintering processing properties; the mechanical properties of the medical artificial joint are close to those of the human bone, and the anti-fatigue property and the anti-corrosion property of the material are good.
Description
Technical field
The invention belongs to medicine and hygiene fields, especially relate to a kind of preparation method of medical artificial joint material.
Background technology
Along with the development of modern medicine and materialogy, medical artificial limb, joint prosthesis, bone anchor, dental implants, heart valve cover etc. for the manufacture of the medical device in implant into body, prosthese or artificial organs and assisting therapy equipment increasingly extensive in the application of medicine and hygiene fields, along with such operation is more and more ripe, the demand of artificial joint increases considerably, and above-mentioned parts have had significant progress in biocompatibility, intensity, plasticity, erosion resistance.The medical alloy used in medical field at present mainly contains Ni-Cr system, Co system, Ti system etc., wherein the Ti-6Al-4V alloy of Ti system is most widely used medical alloy, but discovered in recent years, Ti-6Al-4V alloy in use can separate out vanadium and the aluminum ion of denier, the toxic meeting of the vanadium ion of wherein separating out causes disadvantageous tissue reaction, aluminum ion can cause human nerve disorderly, reduce the defect that cell adaptation etc. works the mischief to human body, solution main at present stops vanadium to a certain extent by top coat and other treatment technology, the precipitation of the toxic element ions such as aluminium, but this method increase the complicacy of manufacturing procedure, improve cost, and still can some vanadium, aluminium toxic element is separated out, reliability can not be guaranteed.
Summary of the invention
In view of this, the invention provides a kind of preparation method of medical artificial joint, the medical artificial joint prepared by it has good intensity, plasticity, erosion resistance, and toxicological harmless, there is good biocompatibility.
The technical scheme that the present invention is complete is:
A preparation method for medical artificial joint material, is characterized in that, precentagewise content weighs required various high pure metals, and wherein the composition of each material consists of:
Nb:0.2%-1.0%, Cu:4.5%-6.0%, Fe:6%-8%, Mo:6%-7%, Mn:0.3% ~ 1.0%, Zr:6% ~ 16%, Ge:0.5% ~ 0.8%, Ga:3%-4%, Cr:2%-4%, Ca:1%-3%, Mg:0.1%-0.3%, In:1%-2%, below C:0.1%, surplus is Ti
Described material is powdery, and wherein the granularity of Ti powder, Zr powder is 100-120 order, and the granularity of Cu powder, Mo powder is 120-160 order, and the granularity of Ca powder, Nb powder, Mn powder, Ge powder is 200-220 order, and the granularity of C powder, Mg powder is 220-240 order,
Fe, Ga, Cr, In are smelted into powder process after Fe-Cr-In-Ga alloy, and the granularity of described Fe-Cr-In-Ga alloy powder is 80-100 order,
Described Fe-Cr-In-Ga alloy powder adopts vacuum induction furnace smelting, first adds in the crucible of induction melting furnace by Fe, Cr, is evacuated down to 10
-4pa, is blown into argon shield, loads power and melts completely to alloy material to 350KW, add Ga, In; be incubated 5 minutes, overturn crucible subsequently, pour in graphite jig; obtain alloy cast ingot, adopt mechanical disintegration or atomization to make the Fe-Cr-In-Ga alloy powder of desired particle size to above-mentioned alloy cast ingot
Remaining element powder is selected corresponding cast metals, after cleaning, adopts mechanical disintegration or atomization to obtain the element powder of desired particle size,
Make the uniform feeding of rheological property in 140 DEG C of mixing 60min in double-planet mixing roll again after above-mentioned all powders are added binding agent, wherein powder loading is 50vol%; Injection machine is shaped to direct injection in the mould of described artificial joint, and injection temperature is 160 ~ 170 DEG C, injection pressure is 70 ~ 100MPa, obtains injecting base substrate; After adopting solvent degreasing and thermal debinding, sinter in vacuum atmosphere, vacuum tightness is 1 × 10
-4pa, sintering temperature is 1100 ~ 1800 DEG C, and soaking time is 180min, obtains described artificial joint.
Preferably, the composition of described material consists of:
Nb:0.4%-0.8%, Cu:5%-5.5%, Fe:6.5%-7.5%, Mo:6.2%-6.8%, Mn:0.5% ~ 0.8%, Zr:10% ~ 13%, Ge:0.6% ~ 0.7%, Ga:3.2%-3.8%, Cr:2.5%-3.5%, Ca:1.5%-2.5%, Mg:0.15%-0.25%, In:1.2%-1.6%, below C:0.06%, surplus is Ti.
Preferably, the composition of described material consists of:
Nb:0.6%, Cu:5.5%, Fe:7%, Mo:6.5%, Mn:0.7%, Zr:12%, Ge:0.65%, Ga:3.5%, Cr:3%, Ca:2%, Mg:0.2%, In:1.4%, C:0.03, surplus is Ti.
The present invention relative to the advantage of prior art is:
The most compatible Ti metal of selection of the present invention and inside of human body environment as alloy substrate, and is selected to add Zr, the elements such as Ge add the biocompatibility of alloy, simultaneously Mn, Fe, Mo, the elements such as Nb exist with solution in Ti alloy, play the effect of solution strengthening, be adopt material of the present invention to obtain the intensity in medical artificial joint much larger than medical pure titanium material, and in working method, add Fe, In, the compositions such as Ga, this composition add the fusing point significantly reducing Ti alloy, make the fusion process in powder process, or follow-up sintering process, all reduce melting or sintering temperature, Ca, C, Cr, Cu, Fe, Mg, the elements such as C define multi-element alloy system, form anode passivation, significantly increase the erosion resistance of alloy to Ti, and arranged by the alloying constituent optimized, make between component, to form stable combination, the obtained artificial joint of this alloy material in inside of human body environment, Cu, the metal ions such as Cr can not be separated out, harmless, have very good biocompatibility.The intensity of this material is to inside of human body environmental friendliness, and density is low, have good melting, sintering processing characteristics, mechanical property close to people's bone, antifatigue, corrosion resistance and good.
Embodiment
Below in conjunction with embodiment, the present invention will be further described.
Precentagewise content weighs required various high pure metals: wherein the composition of each material consists of:
Nb:0.2%-1.0%, Cu:4.5%-6.0%, Fe:6%-8%, Mo:6%-7%, Mn:0.3% ~ 1.0%, Zr:6% ~ 16%, Ge:0.5% ~ 0.8%, Ga:3%-4%, Cr:2%-4%, Ca:1%-3%, Mg:0.1%-0.3%, In:1%-2%, below C:0.1%, surplus is Ti.
Preferably, the composition of described material consists of:
Nb:0.4%-0.8%, Cu:5%-5.5%, Fe:6.5%-7.5%, Mo:6.2%-6.8%, Mn:0.5% ~ 0.8%, Zr:10% ~ 13%, Ge:0.6% ~ 0.7%, Ga:3.2%-3.8%, Cr:2.5%-3.5%, Ca:1.5%-2.5%, Mg:0.15%-0.25%, In:1.2%-1.6%, below C:0.06%, surplus is Ti.
Preferably, the composition of described material consists of:
Nb：0.6％，Cu：5.5％，Fe：7％，Mo：6.5％，Mn：0.7％，Zr：12％，Ge：0.65％，Ga：3.5％，
Cr:3%, Ca:2%, Mg:0.2%, In:1.4%, C:0.03, surplus is Ti.
Described Fe-Cr-In-Ga alloy powder adopts vacuum induction furnace smelting, first adds in the crucible of induction melting furnace by Fe, Cr, is evacuated down to 10
-4pa, is blown into argon shield, loads power and melts completely to alloy material to 350KW; add Ga, In, be incubated 5 minutes, overturn crucible subsequently; pour in graphite jig, obtain alloy cast ingot, adopting mechanical disintegration or atomization to make granularity to above-mentioned alloy cast ingot is 80-100 object powder.
Remaining element powder is selected this element ingot casting, mechanical disintegration or atomization is adopted to make element powder after cleaning, wherein, the granularity of Ti powder, Zr powder is 100-120 order, the granularity of Cu powder, Mo powder is 120-160 order, the granularity of Ca powder, Nb powder, Mn powder, Ge powder is 200-220 order, and the granularity of C powder, Mg powder is 220-240 order.
Make the uniform feeding of rheological property in 140 DEG C of mixing 60min in double-planet mixing roll again after above-mentioned all powders are added binding agent, wherein powder loading is 50vol%; Injection machine is shaped to direct injection in the mould of described artificial joint, and injection temperature is 160 ~ 170 DEG C, injection pressure is 70 ~ 100MPa, obtains injecting base substrate; After adopting solvent degreasing and thermal debinding, sinter in vacuum atmosphere, vacuum tightness is 1 × 10
-4pa, sintering temperature is 1100 ~ 1800 DEG C, and soaking time is 180min, obtains described artificial joint.
Claims (3)
1. the preparation method in medical artificial joint, is characterized in that, precentagewise content weighs required various high pure metals, and wherein the composition of each material consists of:
Nb:0.2%-1.0%, Cu:4.5%-6.0%, Fe:6%-8%, Mo:6%-7%, Mn:0.3% ~ 1.0%, Zr:6% ~ 16%, Ge:0.5% ~ 0.8%, Ga:3%-4%, Cr:2%-4%, Ca:1%-3%, Mg:0.1%-0.3%, In:1%-2%, below C:0.1%, surplus is Ti
Described material is powdery, and wherein the granularity of Ti powder, Zr powder is 100-120 order, and the granularity of Cu powder, Mo powder is 120-160 order, and the granularity of Ca powder, Nb powder, Mn powder, Ge powder is 200-220 order, and the granularity of C powder, Mg powder is 220-240 order,
Fe, Ga, Cr, In are smelted into powder process after Fe-Cr-In-Ga alloy, and the granularity of described Fe-Cr-In-Ga alloy powder is 80-100 order,
Described Fe-Cr-In-Ga alloy powder adopts vacuum induction furnace smelting, first adds in the crucible of induction melting furnace by Fe, Cr, is evacuated down to 10
-4pa, is blown into argon shield, loads power and melts completely to alloy material to 350KW, add Ga, In; be incubated 5 minutes, overturn crucible subsequently, pour in graphite jig; obtain alloy cast ingot, adopt mechanical disintegration or atomization to make the Fe-Cr-In-Ga alloy powder of desired particle size to above-mentioned alloy cast ingot
Remaining element selects corresponding cast metals, adopts mechanical disintegration or atomization to obtain the element powder of desired particle size after cleaning,
Make the uniform feeding of rheological property in 140 DEG C of mixing 60min in double-planet mixing roll again after above-mentioned all powders are added binding agent, wherein powder loading is 50vol%; Injection machine is shaped to direct injection in the mould of described artificial joint, and injection temperature is 160 ~ 170 DEG C, injection pressure is 70 ~ 100MPa, obtains injecting base substrate; After adopting solvent degreasing and thermal debinding, sinter in vacuum atmosphere, vacuum tightness is 1 × 10
-4pa, sintering temperature is 1100 ~ 1800 DEG C, and soaking time is 180min, obtains described artificial joint.
2. the preparation method in medical artificial joint as claimed in claim 1, is characterized in that, the composition of described material consists of:
Nb:0.4%-0.8%, Cu:5%-5.5%, Fe:6.5%-7.5%, Mo:6.2%-6.8%, Mn:0.5% ~ 0.8%, Zr:10% ~ 13%, Ge:0.6% ~ 0.7%, Ga:3.2%-3.8%, Cr:2.5%-3.5%, Ca:1.5%-2.5%, Mg:15%-0.25%, In:1.2%-1.6%, below C:0.06%, surplus is Ti.
3. the preparation method in medical artificial joint as claimed in claim 2, is characterized in that, the composition of described material consists of:
Nb:0.6%, Cu:5.5%, Fe:7%, Mo:6.5%, Mn:0.7%, Zr:12%, Ge:0.65%, Ga:3.5%, Cr:3%, Ca:2%, Mg:0.2%, In:1.4%, C:0.03, surplus is Ti.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105671364A (en) * | 2016-03-29 | 2016-06-15 | 昆明理工大学 | Preparation method of porous titanium copper calcium material |
| CN108285990A (en) * | 2018-01-30 | 2018-07-17 | 宝鸡文理学院 | A kind of new type bone implantation titanium alloy and preparation method thereof |
| JP2018204095A (en) * | 2017-03-29 | 2018-12-27 | ザ・ボーイング・カンパニーＴｈｅ Ｂｏｅｉｎｇ Ｃｏｍｐａｎｙ | Titanium-copper-iron alloy and associated thixoforming method |
| CN109732084A (en) * | 2019-03-21 | 2019-05-10 | 西京学院 | A kind of ferrotitanium molybdenum alloy and preparation method thereof |
| CN114438370A (en) * | 2021-12-31 | 2022-05-06 | 上海精科智能科技股份有限公司 | Lightweight damping flip self-locking orthodontic device and near-net-shape preparation method thereof |
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| CN102021362A (en) * | 2010-11-22 | 2011-04-20 | 哈尔滨工程大学 | Multipurpose Ti-Ge series alloy with adjustable property for oral cavity and preparation method thereof |
| CN103240412A (en) * | 2013-05-22 | 2013-08-14 | 北京科技大学 | Method for preparing powder super-alloy by near net shape |
| CN104745872A (en) * | 2015-04-22 | 2015-07-01 | 哈尔滨工业大学 | High-temperature titanium alloy applicable to use at temperature of 650 DEG C and preparation method thereof |
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2015
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Patent Citations (3)
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| CN102021362A (en) * | 2010-11-22 | 2011-04-20 | 哈尔滨工程大学 | Multipurpose Ti-Ge series alloy with adjustable property for oral cavity and preparation method thereof |
| CN103240412A (en) * | 2013-05-22 | 2013-08-14 | 北京科技大学 | Method for preparing powder super-alloy by near net shape |
| CN104745872A (en) * | 2015-04-22 | 2015-07-01 | 哈尔滨工业大学 | High-temperature titanium alloy applicable to use at temperature of 650 DEG C and preparation method thereof |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105671364A (en) * | 2016-03-29 | 2016-06-15 | 昆明理工大学 | Preparation method of porous titanium copper calcium material |
| JP2018204095A (en) * | 2017-03-29 | 2018-12-27 | ザ・ボーイング・カンパニーＴｈｅ Ｂｏｅｉｎｇ Ｃｏｍｐａｎｙ | Titanium-copper-iron alloy and associated thixoforming method |
| JP7250429B2 (en) | 2017-03-29 | 2023-04-03 | ザ・ボーイング・カンパニー | Titanium-copper-iron alloys and related thixo-forming methods |
| CN108285990A (en) * | 2018-01-30 | 2018-07-17 | 宝鸡文理学院 | A kind of new type bone implantation titanium alloy and preparation method thereof |
| CN109732084A (en) * | 2019-03-21 | 2019-05-10 | 西京学院 | A kind of ferrotitanium molybdenum alloy and preparation method thereof |
| CN109732084B (en) * | 2019-03-21 | 2021-05-11 | 西京学院 | Iron-titanium-molybdenum alloy and preparation method thereof |
| CN114438370A (en) * | 2021-12-31 | 2022-05-06 | 上海精科智能科技股份有限公司 | Lightweight damping flip self-locking orthodontic device and near-net-shape preparation method thereof |
| CN114438370B (en) * | 2021-12-31 | 2022-08-16 | 上海精科智能科技股份有限公司 | Lightweight damping flip self-locking orthodontic device and near-net-shape preparation method thereof |
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Application publication date: 20160224 |