CN105343182A - Medicinal composition for treating cough asthma and chronic bronchitis, and preparation method thereof - Google Patents
Medicinal composition for treating cough asthma and chronic bronchitis, and preparation method thereof Download PDFInfo
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- CN105343182A CN105343182A CN201510805750.0A CN201510805750A CN105343182A CN 105343182 A CN105343182 A CN 105343182A CN 201510805750 A CN201510805750 A CN 201510805750A CN 105343182 A CN105343182 A CN 105343182A
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- chronic bronchitis
- asthma
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Abstract
The invention discloses a medicinal composition for treating cough asthma and chronic bronchitis. The medicinal composition is prepared through mixing 1800 parts by weight of Ficus microcarpa dry extract and 7 parts by weight of chlorphenamine maleate. The invention also provides a preparation method of the medicinal composition. The medicinal composition for treating cough asthma and chronic bronchitis has the cough relieving, panting calming, inflammation eliminating and phlegm expelling effects, and has a good treatment effect on the cough asthma and chronic bronchitis.
Description
Technical field
The present invention relates to and be a kind ofly used for the treatment of pharmaceutical composition of cough with asthma and chronic bronchitis and preparation method thereof.
Background technology
Cough with asthma is the cardinal symptom of pneumonopathy.The cause of disease of cough with asthma has Exogenous and internal injuries not, and pathogenesis has dividing of cold and heat and asthenia and sthenia.Cough with asthma and expectorant closely related, cough with asthma often more presss from both sides expectorant, and expectorant also often causes cough with asthma.
Chronic bronchitis is the chronic nonspecific inflammation of trachea-bronchial epithelial cell mucosa and surrounding tissue.Clinical with cough, expectoration for cardinal symptom, annual morbidity continues 3 months, continuous more than 2 years or 2 years.Need to get rid of the other diseases (as illness such as pulmonary tuberculosis, pneumoconiosis, pulmonary abscess, heart disease, cardiac insufficiency, bronchiectasis, bronchial asthma, chronic nasopharyngitis, esophageal reflux syndromes) with cough, expectoration, wheezing symptoms further.
Summary of the invention
Object of the present invention is exactly for above-mentioned defect of the prior art, provides a kind ofly to be used for the treatment of pharmaceutical composition of cough with asthma and chronic bronchitis and preparation method thereof.
To achieve these goals, technical scheme provided by the invention is: a kind of pharmaceutical composition being used for the treatment of cough with asthma and chronic bronchitis, prepare after being mixed by the following raw material according to parts by weight: Foliole banyan dry extract 1800 parts, chlorphenamine maleate 7 parts.
Second object of the present invention there is provided above-mentioned a kind of preparation method being used for the treatment of the pharmaceutical composition of cough with asthma and chronic bronchitis, in the Foliole banyan sense extractum of formula ratio, add chlorphenamine maleate, and granulate after mixing, be used for the treatment of the pharmaceutical composition of cough with asthma and chronic bronchitis described in can obtaining.
Beneficial effect of the present invention is: a kind of pharmaceutical composition being used for the treatment of cough with asthma and chronic bronchitis provided by the invention, has antitussive and antiasthmatic, the effect that antiinflammatory is eliminated the phlegm, and is used for the treatment of cough with asthma and chronic bronchitis can reach very good effect.
Detailed description of the invention
embodiment 1:
A kind of pharmaceutical composition being used for the treatment of cough with asthma and chronic bronchitis, prepare after being mixed by following raw material: Foliole banyan dry extract 360g, chlorphenamine maleate 1.4g, after mixing, system 1000, is used for the treatment of the pharmaceutical composition of cough with asthma and chronic bronchitis described in can obtaining.
differentiate:
Get this product content 10g, porphyrize, add water 30ml, warmly make dissolving, centrifugal (rotating speed is per minute 4000) 10 minutes, the jolting of supernatant ether extracts 2 times, each 30ml, discard ether solution, aqueous layer with ethyl acetate jolting extracts 2 times, each 30ml, divide and get acetic acid ethyl fluid, recycling design as, residue adds methanol 1ml makes dissolving, as need testing solution.Separately get Foliole banyan control medicinal material 5g, decoct with water 2 times, each 150ml, decoct 30 minutes, collecting decoction, filter, filtrate is concentrated into about 30ml, from " extracting 2 times with ether jolting ", is made in the same way of control medicinal material solution.Get apigenin-8-C-glucoside reference substance again, add methanol and make the solution not having 1ml to contain 0.2mg, in contrast product solution, test according to thin layer chromatography (general rule 0502).Draw need testing solution 2 ~ 8 μ l, control medicinal material solution and each 1 μ l of reference substance solution, put respectively on same polyamide film, making into strips, take acetic acid as developing solvent, launches, take out, dry, spray the aluminum chloride alcoholic solution with 5%, hot blast drying, inspect under ultraviolet light (365nm), in test sample chromatograph, on the position corresponding to control medicinal material chromatograph, the fluorescence speckle of at least aobvious 2 same colors; On the position corresponding to reference substance chromatograph, the fluorescence speckle of aobvious same color.
assay:
Foliole banyan dry extract measures according to high performance liquid chromatography (general rule 0512).
Chromatographic condition and system suitability: take octadecylsilane chemically bonded silica as filler; Take methanol as mobile phase A .0.05% phosphoric acid solution be Mobile phase B, carry out gradient elution by the regulation in table 1; Detecting liquid long is 335nm.Number of theoretical plate calculates should be not less than 3000 by apigenin-8-C-glucoside peak.
Table 1
time (minute) mobile phase A (%) Mobile phase B %
0～5525→3575→65
55～5635→2565→75
56～652575
the preparation of reference substance solution: get apigenin-8-C-glucoside reference substance appropriate, accurately weighed, make the solution not having 1ml to contain 10 μ g with 70% methanol, to obtain final product.
the preparation of need testing solution: get this product content under content uniformity item, porphyrize, get about 1.4g accurately weighed, put in tool conical flask, precision adds the close plug of 70% methanol 50ml., weighed weight, supersound process (power 250W, frequency 40KHZ) 45 minutes, lets cool, in weighed weight, supply the weight of less loss for 70% methanol, shake up, filter, get subsequent filtrate, to obtain final product.
algoscopy: accurate absorption reference substance solution and each 10ul of need testing solution respectively, injection liquid chromatography, measures.With apigenin-8-C-glucoside reference substance for reference, with its corresponding peak for s peak.Calculate the relative retention time of Saponaretin, its relative retention time should setting+scope of-5% within.Relative retention time and relative correction factor as shown in table 2.
Table 2
composition to be measured (peak) relative retention time relative correction factor
Saponaretin 1.30.90
apigenin-8-C-glucoside 1.01.00
This product every contains Foliole banyan dry extract with apigenin-8-C-glucoside (C
21h
20o
39) and Saponaretin (C
21h
20o
10) total amount, must not 0.28mg be less than.
Chlorphenamine maleate measures according to high performance liquid chromatography (general rule 0512).
Chromatographic condition and system suitability take octadecylsilane chemically bonded silica as filler; Be mobile phase with methanol-0.05mo1/L potassium dihydrogen phosphate (every 100ml adds the triethylamine of 0.5ml, is 3.6 by phosphoric acid adjust ph) (39::61); Determined wavelength is 262nm, column temperature 40.c.Number of theoretical plate calculates should be not less than 3000. by chlorphenamine peak
The preparation of reference substance solution is got chlorphenamine maleate and is solely shone product in right amount, accurately weighed, adds methanol supersound process and makes dissolving and make the solution of every 1ml containing 80 μ g, to obtain final product.
the preparation of need testing solutionget this product content under content uniformity item, porphyrize, get appropriate (being about equivalent to Malaysia Su Na chlorphenamine 2.1mg) accurately weighed, put in tool match conical flask, precision adds hydrochloric acid-methanol (1:100) 25ml, close plug, weighed weight, supersound process (power 250W, frequency 50KHz) 20 minutes, let cool, more weighed weight, the weight of less loss is supplied with hydrochloric acid-methanol (1:100), shake up, filter, get subsequent filtrate, to obtain final product.
algoscopyaccurate absorption reference substance solution and each 10ul of need testing solution respectively, injection liquid chromatography, measures, by external standard method with chlorphenamine areal calculation, to obtain final product.
This product every is containing chlorphenamine maleate (C
16h
19cIN
2.C
4h
4o
4) should be 80.0% ~ 120.0% of expression amount.
Last it is noted that the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (2)
1. being used for the treatment of a pharmaceutical composition for cough with asthma and chronic bronchitis, it is characterized in that, is prepare after being mixed by the following raw material according to parts by weight: Foliole banyan dry extract 1800 parts, chlorphenamine maleate 7 parts.
2. a kind of preparation method being used for the treatment of the pharmaceutical composition of cough with asthma and chronic bronchitis according to claim 1, it is characterized in that, in the Foliole banyan sense extractum of formula ratio, add chlorphenamine maleate, and granulate after mixing, be used for the treatment of the pharmaceutical composition of cough with asthma and chronic bronchitis described in can obtaining.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510805750.0A CN105343182A (en) | 2015-11-20 | 2015-11-20 | Medicinal composition for treating cough asthma and chronic bronchitis, and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510805750.0A CN105343182A (en) | 2015-11-20 | 2015-11-20 | Medicinal composition for treating cough asthma and chronic bronchitis, and preparation method thereof |
Publications (1)
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|---|---|
| CN105343182A true CN105343182A (en) | 2016-02-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510805750.0A Pending CN105343182A (en) | 2015-11-20 | 2015-11-20 | Medicinal composition for treating cough asthma and chronic bronchitis, and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107456483A (en) * | 2017-08-31 | 2017-12-12 | 吉林修正药业新药开发有限公司 | A kind of pharmaceutical composition for being used for cough and asthma and chronic bronchitis and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1723964A (en) * | 2005-06-22 | 2006-01-25 | 叶耀良 | Medicine for treating cough and chronic bronchitis |
-
2015
- 2015-11-20 CN CN201510805750.0A patent/CN105343182A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1723964A (en) * | 2005-06-22 | 2006-01-25 | 叶耀良 | Medicine for treating cough and chronic bronchitis |
Non-Patent Citations (2)
| Title |
|---|
| 国家药典委员会: "《中华人民共和国药典：2015年版.一部》", 30 June 2015, 中国医药科技出版社 * |
| 张耕武: "高效液相色谱法测定咳特灵片中马来酸氯苯那敏的含量", 《海峡药学》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107456483A (en) * | 2017-08-31 | 2017-12-12 | 吉林修正药业新药开发有限公司 | A kind of pharmaceutical composition for being used for cough and asthma and chronic bronchitis and preparation method thereof |
| CN107456483B (en) * | 2017-08-31 | 2020-05-19 | 吉林修正药业新药开发有限公司 | A pharmaceutical composition for treating cough and asthma and chronic bronchitis, and its preparation method |
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Application publication date: 20160224 |
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