CN105343145A - Saussurea involucrate and cordyceps sinensis lozenge and preparation method thereof - Google Patents
Saussurea involucrate and cordyceps sinensis lozenge and preparation method thereof Download PDFInfo
- Publication number
- CN105343145A CN105343145A CN201510929598.7A CN201510929598A CN105343145A CN 105343145 A CN105343145 A CN 105343145A CN 201510929598 A CN201510929598 A CN 201510929598A CN 105343145 A CN105343145 A CN 105343145A
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- China
- Prior art keywords
- powder
- cordyceps sinensis
- cordyceps
- herba saussureae
- saussureae involueratae
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- 241001248610 Ophiocordyceps sinensis Species 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 241000133134 Saussurea Species 0.000 title abstract 7
- 239000007937 lozenge Substances 0.000 title abstract 6
- 239000000843 powder Substances 0.000 claims abstract description 35
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 16
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 14
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000000811 xylitol Substances 0.000 claims abstract description 14
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 14
- 229960002675 xylitol Drugs 0.000 claims abstract description 14
- 235000010447 xylitol Nutrition 0.000 claims abstract description 14
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 13
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 13
- 229920002472 Starch Polymers 0.000 claims abstract description 13
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 13
- 239000008107 starch Substances 0.000 claims abstract description 13
- 235000019698 starch Nutrition 0.000 claims abstract description 13
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 9
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 8
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract description 8
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims abstract description 8
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 241001122767 Theaceae Species 0.000 claims abstract 3
- 241000190633 Cordyceps Species 0.000 claims description 27
- 239000006189 buccal tablet Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 8
- 239000000741 silica gel Substances 0.000 claims description 7
- 229910002027 silica gel Inorganic materials 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 238000000748 compression moulding Methods 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 235000011837 pasties Nutrition 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 12
- 238000010521 absorption reaction Methods 0.000 abstract description 6
- 210000004072 lung Anatomy 0.000 abstract description 5
- 210000003734 kidney Anatomy 0.000 abstract description 4
- 208000000059 Dyspnea Diseases 0.000 abstract description 2
- 206010013975 Dyspnoeas Diseases 0.000 abstract description 2
- 208000006673 asthma Diseases 0.000 abstract description 2
- 208000019914 Mental Fatigue Diseases 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 208000013220 shortness of breath Diseases 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 244000269722 Thea sinensis Species 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 229940046011 buccal tablet Drugs 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 2
- 208000005946 Xerostomia Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 206010013781 dry mouth Diseases 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 241001480006 Clavicipitaceae Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000130660 Hepialidae Species 0.000 description 1
- 241000330899 Hepialus Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 244000017020 Ipomoea batatas Species 0.000 description 1
- 235000002678 Ipomoea batatas Nutrition 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 235000020094 liqueur Nutrition 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention provides a saussurea involucrate and cordyceps sinensis lozenge and a preparation method thereof for solving the problems. The saussurea involucrate and cordyceps sinensis lozenge is prepared from the following raw materials by weight proportion: 200 to 300mg of saussurea involucrate powder, 50 to 150mg of cordyceps sinensis powder, 50 to 100mg of starch, 100 to 150mg of xylitol, 150 to 200mg of maltodextrin, 10 to 20mg of tea powder, 1 to 2mg of superfine silica powder, 1 to 2mg of magnesium stearate and 2 to 3mg of carboxymethylcellulose. The saussurea involucrate and cordyceps sinensis lozenge is scientific in formula and unique in function; due to the fact that the saussurea involucrate is added for matching, the rate of absorption and utilization of the cordyceps sinensis is greatly improved, and the efficacy of the lozenge is enriched; the saussurea involucrate and cordyceps sinensis lozenge has the functions of moistening lung and tonifying kidney, enhancing human immunity and resisting rejection, and has very good curative effects and effects on shortness of breath, asthma, thirty mouth, mental fatigue and the like.
Description
Technical field
The present invention relates to a kind of Cordyceps sinensis buccal tablets and preparation method thereof, particularly relate to a kind of Herba Saussureae Involueratae Cordyceps sinensis buccal tablets and preparation method thereof, belong to biological health-care product field.
Background technology
Cordyceps is the traditional rare Chinese medicine of China, equally celebrated for their achievements with Radix Ginseng, Cornu Cervi Pantotrichum, is listed as three large tonics.Cordyceps is the larva cadaveric complex of the Stroma and host's Hepialidae insecticide Hepialus armorieanus Oberthur etc. thereof of Clavicipitaceae plant Cordyceps, be distributed in the mesophorbium, coryphile of the ground height above sea level more than 3000 meters such as Qinghai, Tibet, Sichuan, Yunnan, Guizhou, Gansu, the effects such as Cordyceps has kidney-replenishing, kidney tonifying essence, tonifying the lung gas, expelling phlegm for arresting cough are relievingd asthma, lung benefiting is cloudy, it is the key medicine for the treatment of chronic cough dyspnea due to deficiency, modern study shows, it has immunomodulating, anticancer, resisting fatigue, the anti-ageing effect of waiting for a long time.
Product at present in this mainly contains cordyceps sinensis medicine liqueur, Cordyceps patent medicine and cordyceps medicinal food etc., but all only rests on simple, coarse, original basis, its utilization rate and to take effect all not good, causes very large waste.As extremely famous and precious Chinese medicine, people often wish by being ground into superfine powder, to improve the absorption rate of human body to it to greatest extent, Cordyceps is directly pulverized, although also can obtain superfine powder, but other adjuvant is added when preparing preparation, as the macromolecular substances such as sodium carboxymethyl cellulose, microcrystalline Cellulose, its bury function also can affect dissolving and the absorption of Cordyceps, if do not add any adjuvant, make so-called pure powder, its solution absorption and mouthfeel neither be fine.
Summary of the invention
The present invention provides a kind of Herba Saussureae Involueratae Cordyceps sinensis buccal tablets and preparation method thereof to solve the problem exactly, this buccal tablet scientific formulation, function is unique, and join assistant owing to adding Herba Saussureae Involueratae, the absorption rate substantially increasing Cordyceps has enriched effect of buccal tablet, there is lung moistening the kidney invigorating, strengthen the function of resistance of human body and immunologic rejection.To breathing hard, pant, the symptom such as xerostomia and metal fatigue has good curative effect or effect.
In order to solve the problems of the technologies described above, the present invention is achieved through the following technical solutions:
A kind of Herba Saussureae Involueratae Cordyceps sinensis buccal tablets, it is prepared from by weight ratio by following raw material: Herba Saussureae Involueratae powder 200-300mg, Cordyceps powder 50-150mg, starch 50-100mg, xylitol 100-150mg, maltodextrin 150-200mg, tea powder 10-20mg, micropowder silica gel 1-2mg, magnesium stearate 1-2mg, carboxymethyl cellulose 2-3mg.
Described Herba Saussureae Involueratae Cordyceps sinensis buccal tablets, it is prepared from by weight ratio by following raw material: Herba Saussureae Involueratae powder 260mg, Cordyceps powder 80mg, starch 75mg, xylitol 120mg, maltodextrin 180mg, tea powder 16mg, micropowder silica gel 1.5mg, magnesium stearate 1mg, carboxymethyl cellulose 2.5mg.
A kind of manufacture method of described Herba Saussureae Involueratae Cordyceps sinensis buccal tablets, get the Herba Saussureae Involueratae, Cordyceps powder, starch and xylitol and the maltodextrin that meet described parts by weight room temperature and put into a mixing bowl mix homogeneously, the pure water of scalding, cool to 30-40 DEG C, water to pour in a mixing bowl and is uniformly mixed by the ratio being 10: 3 in the weight ratio of material in a mixing bowl and water, cover lid stirs 1-2 hour, to be mixed to pasty state post-drying, then compression molding.
Advantage of the present invention and effect as follows:
The present invention is different from traditional Cordyceps patent medicine, and the present invention with the addition of Herba Saussureae Involueratae on the basis of Cordyceps, improves effect of Cordyceps sinensis buccal tablets; Add tea powder and xylitol substantially improves mouthfeel.The processing technology of buccal tablet of the present invention is also different from traditional method, compared with simple traditional method, present invention employs premixing stirring, the gelatinizing that adds water stirring, makes Cordyceps fully mix with batching the absorption efficiency greatly improving Cordyceps; Oven drying at low temperature technique effectively ensures that the main component of Cordyceps can not be subject to temperatures involved, and effect of Cordyceps sinensis buccal tablets is maximized the retention, and this is that traditional handicraft is not accomplished.。Cordyceps sinensis buccal tablets scientific formulation of the present invention, function is unique, has lung moistening the kidney invigorating, strengthens the function of resistance of human body and immunologic rejection.To breathing hard, pant, the symptom such as xerostomia and metal fatigue has good curative effect or effect.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further details, but protection scope of the present invention not limit by embodiment.
Embodiment 1:
Herba Saussureae Involueratae Cordyceps sinensis buccal tablets of the present invention, it is prepared from by weight ratio by following raw material: seven powder 200-300mg, Cordyceps powder 50-150mg, starch 50-100mg, xylitol 100-150mg, maltodextrin 150-200mg, tea powder 10-20mg, micropowder silica gel 1-2mg, magnesium stearate 1-2mg, carboxymethyl cellulose 2-3mg.
The manufacture method of Herba Saussureae Involueratae Cordyceps sinensis buccal tablets, it is characterized in that getting the Herba Saussureae Involueratae, Cordyceps powder, starch and xylitol and the maltodextrin that meet described parts by weight room temperature and put into a mixing bowl mix homogeneously, the pure water of scalding, cool to 30-40 DEG C, water to pour in a mixing bowl and is uniformly mixed by the ratio being 10: 3 in the weight ratio of material in a mixing bowl and water, cover lid stirs 1-2 hour, to be mixed to pasty state post-drying, then compression molding.
Embodiment 2:
A kind of Herba Saussureae Involueratae Cordyceps sinensis buccal tablets, it is prepared from by weight ratio by following raw material: Herba Saussureae Involueratae powder 260mg, Cordyceps powder 80mg, starch 75mg, xylitol 120mg, maltodextrin 180mg, tea powder 16mg, micropowder silica gel 1.5mg, magnesium stearate 1mg, carboxymethyl cellulose 2.5mg.
The manufacture method of Herba Saussureae Involueratae Cordyceps sinensis buccal tablets, it is characterized in that getting the Herba Saussureae Involueratae, Cordyceps powder, starch and xylitol and the maltodextrin that meet described parts by weight room temperature and put into a mixing bowl mix homogeneously, the pure water of scalding, cool to 36 DEG C, water to pour in a mixing bowl and is uniformly mixed by the ratio being 10: 3 in the weight ratio of material in a mixing bowl and water, cover lid stirs 1 hour, to be mixed to pasty state post-drying, then compression molding.
Embodiment 3:
A kind of Herba Saussureae Involueratae Cordyceps sinensis buccal tablets, it is prepared from by weight ratio by following raw material: Herba Saussureae Involueratae powder 200mg, Cordyceps powder 50mg, starch 50mg, xylitol 100mg, maltodextrin 150mg, tea powder 10mg, micropowder silica gel 1mg, magnesium stearate 1mg, carboxymethyl cellulose 2mg.
The manufacture method of seven Cordyceps sinensis buccal tabletses, it is characterized in that getting the Herba Saussureae Involueratae, Cordyceps powder, starch and xylitol and the maltodextrin that meet described parts by weight room temperature and put into a mixing bowl mix homogeneously, the pure water of scalding, cool to 40 DEG C, water to pour in a mixing bowl and is uniformly mixed by the ratio being 10: 3 in the weight ratio of material in a mixing bowl and water, cover lid stirs 2 hours, to be mixed to pasty state post-drying, then compression molding.
Adopt the Herba Saussureae Involueratae Cordyceps sinensis buccal tablets that the method for embodiment of the present invention 1-3 is obtained, adopt the conventional method detecting purple sweet potato powder to detect,
Physical and chemical index
Cordyceps content/(mg/G) >=50.0
Sanitary index
The project indicator
Total arsenic (in As)/(mg/G)≤0.1
Plumbous (with Pb)/(mg/G)≤0.03
Microbiological indicator
Claims (4)
1. a Herba Saussureae Involueratae Cordyceps sinensis buccal tablets, it is characterized in that it is prepared from by weight ratio by following raw material: Herba Saussureae Involueratae powder 200-300mg, Cordyceps powder 50-150mg, starch 50-100mg, xylitol 100-150mg, maltodextrin 150-200mg, tea powder 10-20mg, micropowder silica gel 1-2mg, magnesium stearate 1-2mg, carboxymethyl cellulose 2-3mg.
2. a kind of Herba Saussureae Involueratae Cordyceps sinensis buccal tablets according to claim 1, it is characterized in that it is prepared from by weight ratio by following raw material: Herba Saussureae Involueratae powder 260mg, Cordyceps powder 80mg, starch 75mg, xylitol 120mg, maltodextrin 180mg, tea powder 16mg, micropowder silica gel 1.5mg, magnesium stearate 1mg, carboxymethyl cellulose 2.5mg.
3. the manufacture method of a Herba Saussureae Involueratae Cordyceps sinensis buccal tablets according to claim 1, it is characterized in that getting the Herba Saussureae Involueratae, Cordyceps powder, starch and xylitol and the maltodextrin that meet described parts by weight room temperature and put into a mixing bowl mix homogeneously, the pure water of scalding, cool to 30-40 DEG C, water to pour in a mixing bowl and is uniformly mixed by the ratio being 10: 3 in the weight ratio of material in a mixing bowl and water, cover lid stirs 1-2 hour, to be mixed to pasty state post-drying, then compression molding.
4. the manufacture method of Herba Saussureae Involueratae Cordyceps sinensis buccal tablets as claimed in claim 3, is characterized in that bake out temperature is 40-50 degree.
Priority Applications (1)
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CN201510929598.7A CN105343145A (en) | 2015-12-14 | 2015-12-14 | Saussurea involucrate and cordyceps sinensis lozenge and preparation method thereof |
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CN201510929598.7A CN105343145A (en) | 2015-12-14 | 2015-12-14 | Saussurea involucrate and cordyceps sinensis lozenge and preparation method thereof |
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CN201510929598.7A Pending CN105343145A (en) | 2015-12-14 | 2015-12-14 | Saussurea involucrate and cordyceps sinensis lozenge and preparation method thereof |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108464500A (en) * | 2018-03-13 | 2018-08-31 | 武春风 | A kind of dietary composition of auxiliary adjustment hypertension |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101926842A (en) * | 2010-09-07 | 2010-12-29 | 郭景龙 | Medicinal composition prepared from raw materials containing snow lotus and fermented cordyceps fungal powder |
CN103652846A (en) * | 2012-09-25 | 2014-03-26 | 江苏学府生物工程有限公司 | Production method for cordyceps militaris buccal tablets |
CN104642616A (en) * | 2015-02-12 | 2015-05-27 | 中国农业科学院茶叶研究所 | Processing method of tea lozenge |
-
2015
- 2015-12-14 CN CN201510929598.7A patent/CN105343145A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101926842A (en) * | 2010-09-07 | 2010-12-29 | 郭景龙 | Medicinal composition prepared from raw materials containing snow lotus and fermented cordyceps fungal powder |
CN103652846A (en) * | 2012-09-25 | 2014-03-26 | 江苏学府生物工程有限公司 | Production method for cordyceps militaris buccal tablets |
CN104642616A (en) * | 2015-02-12 | 2015-05-27 | 中国农业科学院茶叶研究所 | Processing method of tea lozenge |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108464500A (en) * | 2018-03-13 | 2018-08-31 | 武春风 | A kind of dietary composition of auxiliary adjustment hypertension |
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