CN105334300A - Rapid method for screening treatment effectiveness of biological source substance - Google Patents
Rapid method for screening treatment effectiveness of biological source substance Download PDFInfo
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- CN105334300A CN105334300A CN201410376550.3A CN201410376550A CN105334300A CN 105334300 A CN105334300 A CN 105334300A CN 201410376550 A CN201410376550 A CN 201410376550A CN 105334300 A CN105334300 A CN 105334300A
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Abstract
The invention relates to a biological source medicament, especially relates to a method for screening biological source medicaments. A rapid method for screening treatment effectiveness of a biological source substance comprises analysis and purification of various biological source substances; substances with the following general formula can be used as an effective ingredient for medicines and compositions thereof: R1(X)nR2, wherein X is one or more selected from O, S, Se, N and C, n equals to 1-5, and R1 and R2 are respectively selected from the group consisting of chain unsaturated hydrocarbon, cyclic hydrocarbon, aromatic hydrocarbon and glycoside derivatives. The invention can greatly reduce the cost of drug development, rapid screen suitable drugs, and shorten the drug development cycle.
Description
Technical field
The present invention relates to biogenic medicine, particularly relate to a kind of biogenic medicament selection method.
Background technology
In acquired immune deficiency syndrome (AIDS), SARS, bird flu, many drug Resistant Pulmonary Tuberculosis, tumour, occurred frequently and antibiotic general resistance etc., brings a difficult problem to the world of medicine of the world.In this context, there is the symptom of a trend of seeking help from Chinese herbal medicine in the medicine scholar of west, intended the plant that 40,000 kinds relate to Chinese herbal medicine, for high flux screening.The application thinks, if west this measure can be successful, will be the disaster of Chinese herbal medicine, and the medicine researched and developed based on Chinese herbal medicine for west is also paid expensive cost by the common people of China, and the medical personal as China must do more work for this reason.
Modern viral germ is emerged in an endless stream, and causes new medicament research and development task very heavy.Current chemical classes medicine is all design large quantities of molecules, then carries out high flux screening to find suitable medicine.This is one of reason that modern medicines valency is very high, is also the reason of medicament research and development cycle length.If a kind of rapid screening method can be found, then object can be had with having direction to select the molecular structure be applicable to, do various animal and clinical testing, greatly can reduce the medicine high cost that high flux screening causes.
Summary of the invention
The object of this invention is to provide the rapid screening method that a kind of kind comes from the validity of curing the disease of biogenic material.The present invention can reduce the cost of medicament research and development greatly, and rapid screening goes out applicable medicine, shortens the medicament research and development cycle.
A kind of rapid screening method coming from the validity of curing the disease of biogenic material of the present invention, analyze various biology of purifying, analyze its structure, have the material of following general formula all to can be used as effective constituent for medicine and composition thereof:
R
1(X)
nR
2
Wherein,
X be in O, S, Se, N or C one or several,
n=1-5、
R
1and R
2be selected from one of derivant of chain unsaturated hydrocarbon, cyclic hydrocarbon, aromatic hydrocarbon or glucoside respectively.
The described rapid screening method coming from the validity of curing the disease of biogenic material, described X is S or Se; N=1-3.
The described rapid screening method coming from the validity of curing the disease of biogenic material, described R
1=R
2.
The described rapid screening method coming from the validity of curing the disease of biogenic material, the derivant of described glucoside comprises oxygen glucoside, sulphur glucoside, nitrogen glucoside, carbon glucoside, glycosides displayed or saponin.
The present invention proposes the molecular structure rule coming from biogenic medicine, utilize this rule can find suitable molecule fast, and find corresponding Chinese herbal medicine or animals and plants by this molecule, therefore can shorten a large amount of time for medicament research and development, reduce huge cost.And because the plant of many Chinese herbal medicines is all derived from China, the monopolization of west to medicament research and development will be broken away from, once there is new viral germ, the pharmacy corporation of China can find suitable biology fast, at low cost, and make corresponding medicine fast, seize market, thus counter is formed to west pharmacy corporation, so by greatly improving the competitiveness of medicine enterprise of China, in international game, more there is right of speech.
In view of characteristic of low cost of the present invention, the mankind will obtain the lower medicine of price, for the people of low-income groups and poor and under-developed area, not less than being huge Gospel.
Embodiment
Come from a rapid screening method for the validity of curing the disease of biogenic material, analyze various biology of purifying, analyze its structure, have the material of following general formula all to can be used as effective constituent for medicine and composition thereof:
R
1(X)
nR
2
Wherein,
X is one or several in O, S, Se, N or C
n=1-5
R
1and R
2be selected from one of derivant of chain unsaturated hydrocarbon, cyclic hydrocarbon, aromatic hydrocarbon or glucoside respectively.
The described rapid screening method coming from the validity of curing the disease of biogenic material, described X is S or Se; N=1-3.
The described rapid screening method coming from the validity of curing the disease of biogenic material, described R
1=R
2.
Below described general formula is described
Ester ether structure
X is the core of whole molecule, is made up of respectively S, O, Se tri-elements.
N=1-5, in a molecule only by element sulphur form and S element more than 3, to be found in sea life, but common in the Liliaceae allium of Lu Sheng.
If the core of molecule only has O element to form, namely n=1-2 forms ether, ester, but is present in plant with the form of glucoside containing oxygen ester ether majority at nature.
Medicine molecule core is made up of jointly sulphur, oxygen, and oxygen element number more than element sulphur time, microorganism easily produces and the property of medicine, as sulfonamides this kind of compound (medicine).
Medicine molecule core is made up of oxygen element entirely, so also easily produces drug resistance, as Anti-HIV agents tenofovir (Tenofouir).
When the core of molecule is made up of element sulphur entirely, so this organism does not produce or not easily produces drug resistance because virus waits microorganism and the mankind, the chemotactic factor (CF) of mammal have 25% homology.
R：
R
1=R
2=unsaturated hydrocarbon, hydrocarbon can be chain hydrocarbon, cyclic hydrocarbon, aromatic hydrocarbons, unsaturated hydrocarbon, and oxidisability is strong; Otherwise then oxidisability is weak, it has significant impact, as R to the chemical property of whole molecule
1=R
2in situation, there is CH
2=CH-CH
2-SS-CH
2-CH=CH
2(diallyl disulfide ester), if both are different, as CH
3sSCH
2-CH=CH
2(methacrylic dithioesters)
The structure of glucoside, glucoside is combined into by the oxygen on glucoside, sulphur, selenium, nitrogen, carbon and one or more glucose.Glucoside is prevalent in book on Chinese herbal medicine, and triterpenoid saponin is distributed widely in the plants such as pulse family, Araliaceae Polygalaceae and Curcurbitaceae.Steroid saponin is mainly distributed in the plants such as Dioscoreaceae, Liliaceae, Scrophulariaceae, and sulphur glucoside is mainly distributed in Cruciferae, liliaceous plant, and flavonoids is mainly distributed in Rutaceae, labiate.
Oxygen glucoside: oxygen glucoside is common in book on Chinese herbal medicine, as panaxoside.
Sulphur glucoside: sulphur glucoside is more common in crucifer, as sinalbin.
Nitrogen glucoside: as gland glucoside, bird glucoside.Similar nitrogen glucoside have alkaloid, alkaloid often has nitrogen electronegativity and water-soluble.Alkaloid is mostly in fat-soluble, and namely tool is amphiphilic, therefore they is listed in nitrogen glucoside, as little wall alkali.
Carbon glucoside: carbon glucoside be by glucoside on hydrogen form with sugar or sugared derivant hemiacetal (hemiketal) hydroxyls dehydrate condensation.Carbon glucoside is common in Verbenaceae, as the Vitexin in Vitex negundo var cannabifolia.
Glycosides displayed: glycosides displayed is formed, as the abrasine in legume jequirity by the hydroxyl on flavonoids organism and glucose condensation.
Also have other glucosides many, be present in each Plants, cannot enumerate herein as space is limited.
In 1012 organic molecules of China's book on Chinese herbal medicine 10%, glucoside 203,130, glucoside unit, alkaloid 160, ester 14, count 507, account for half of rivers and mountains, they all have fat-soluble, there is again water miscible amphipathic characteristics, namely all possessed the cell membrane that can pass through people and mammal to enter in cell, but killed the function of pathogenic microorganisms in cell, for the health procreation of the Chinese nation provides material guarantee.
Saponin: saponin has triterpenoid saponin, steroid saponin
Triterpenoid saponin: its characteristic be it aqueous solution slightly jolting will produce a large amount of immediately, the long-time soap bubble sample foam do not disappeared, this kind of saponin is book on Chinese herbal medicine is produce under evolution pressure under the invasion and attack suffering microorganism, to resist virus, such as full staphylococcus aureus, the G such as branch tubercle bacillus
+bacterium, verdigris vacation end born of the same parents bacterium (Pseudomonas aeruginosa), the G such as typhoid bacillus, shigella dysenteriae
-bacterium, and the fungi such as Candida albicans, cryptococcus.
Saponin is kind of a surfactant, its foam surface has a kind of surface tension contrary with pathogenic germ cells wall (film) surface direction, causes the intracellular penetration pressure of pathogenic microorganisms to exceed its surface tension and cell membrane (film) is broken even violence and dead.Here it must be noted that the mankind, mammal are in the mode of mouth picked-up but not the mode injected by blood vessel in its long-term evolution process, do not have to form the mechanism injected from vein blood vessel, so likely hemolytic reaction can be there is as the book on Chinese herbal medicine containing triterpenoid saponin, steroid saponin made intravenous fluid injection human body, even there is life danger.60, have to abandon through the project of the Chinese holly intravenous fluid replacement penicillin of 10 years research cooperation the seventies.But Chinese holly oral liquid does not have haemocylolysis, because the tannin also containing hemoglutination in Chinese holly, cancel out each other, tannin also has antibacterial action.We should draw lesson from it, and make full use of its profit and keep away its evil.
Steroid saponin: steroid saponin has certain hormone-like effect, remaining same triterpenoid saponin.
Flavonoid glycosides: in the books on Chinese herbal medicine such as flavonoid glycosides is prevalent in Rutaceae, pulse family, the anti-pathogenic microorganisms of flavonoids book on Chinese herbal medicine mainly has (methyl ether groups, its rare 1,3,5 at most, even 6,7) by it.Microbiologist distinguishes envelope virus and nonenveloped virus with ether, and ether can kill envelope virus.The amphiphilic organism that flavonoids is not too water-soluble, glycosides displayed then water-solublely can be dissolved in again fat.
Alkaloid and Anthraquinones book on Chinese herbal medicine
Because in alkaloid, some contains N
+(become negative oxygen) or salt, can be water-soluble, both can be dissolved in again the amphiphilic alkaloid that ester can be water-soluble, make them can enter in human body cell, as jamaicin 9,10 has-OCH containing ester (ether) group
3, and tetrahydropalmatine and colchicine reach 4, also have aconitine.Jamaicin is because containing-OCH
3group, and there is antibiosis and antiviral functions, and tetrahydropalmatine and colchicin tool analgesic effect, atropine, the hyoscine with spasmolysis have lactone groups.
Because of quinones organism, majority has and is not only dissolved in ester but also water-solublely also returns together, as the Physcion in rheum officinale has antibacterial catharsis effect.
Containing ester, the 19%(that the herbal molecule of ether group accounts for herbal molecule does not comprise quinone)
Containing three large features of unsaturated thioesters book on Chinese herbal medicine
We select ubiquitous two sulphur two propylenes in Liliaceae (green onion garlic) plant
(CH
2=CH-CH
2sSCH
2-CH=CH
2) and methacrylic dithioesters
(CH
3sSCH
2-CH=CH
2) pharmacological mechanism of beta-unsaturated esters in Chinese book on Chinese herbal medicine is described
Two sulphur two propylenes: be prevalent in green onion garlic plant (garlic, onion, Longstamen Onion Bulb head), oily liquids is kind of an extremely strong oxygenant.
Double bond: double bond is necessary component in its molecular structure, there is the feature of alkene---additivity: can hydrogenation, so it can attract the hydrogen ion in pathogenic microorganisms body and kill them, so two sulphur two propylenes not only can kill envelope virus, nonenveloped virus (destroying the amino acid of its protein) can also be killed, as adenovirus etc.Because heavy metal ion is positively charged, so two sulphur two propylenes can adsorb heavy metal in human body ion, as Pb, Hg, Cd, As plasma, for removing toxic substances (for heavy metal poisoning).
Duality: refer to two sulphur diallyl oxygenation effects, namely it also have reducing action (reductive agent) can be formed as shown in the formula epoxy construction:
CH
2－CH－CH
2SS－CH
2－CH－CH
2，
OO
Once form this epoxide, its oxidisability is stronger, because oxirane has extremely strong penetration power, for high-grade amenities of sterilizing.Also have epoxide group in astragalin, this and Radix Astragali antibiosis and antiviral functions have some relations more by force.
As a same reason, the free radical oxygen in two sulphur two propylene energy and in body, in and the acute myocardial infarction AMI oxygen that stress discharge.So two sulphur two propylenes are applicable to acute myocardial infarction AMI very much, and various bacteria, acute and chronic pericarditis, myocarditis and endocarditis that virus causes.Over 40 years, about the report of this respect is not within minority.
Amphiphilic: Small molecular thioesters, as two sulphur two propylene, Ailitridin, sulphur two propylene; Methacrylic thioesters etc. is prevalent in Liliaceae (green onion garlic) plant.Through experiment, facts have proved, they are not only dissolved in ester but also water-soluble, are kind of parents' agent, so the ability that they have 7 cross-films enters in human body cell, kill and invade intracellular various virus, comprise nonenveloped virus; The G-bacillus such as verdigris vacation end born of the same parents bacterium (Pseudomonas aeruginosa), typhoid bacillus, shigella dysenteriae invaded in born of the same parents can be killed; Can also staphylococcus aureus be killed, the G+ bacterium such as Much's bacillus, can also the fungi such as Killing Candida Albicans and cryptococcus, can also killing off tumor cells.Ask for an interview attached 3rd the People's Hospital of Shanghai second medical college, the pharmacological evaluation of garlic and clinical practice overview, Chinese herbal medicine communication, the 10th phase in 1976.
Unsaturated thioesters amphiphilic, has sympathy with human body cell, has compatibility with tissue, guarantee nontoxic, the low toxicity to human body.
Various thioesters above-mentioned, be kind of an oil at normal temperatures, people generally believe that oil does not dissolve in water, and actually this is not so: by R
1sSR
2molecular formula can be found out ,-SS-is electronegative, can attract the H in water
+and make R
1sSR
2be slightly soluble in water, the Ye Yuankang of Bengbu Medical College and USA New York commemorate that the experiment of Tang Na mono-Armstrong of this grand Kate woods tumor center proves that the solubleness of allicin is 2.5%, see Bengbu Medical College's journal, 1990.4.Just take into account this characteristic but I had never expected that it is than water weight during Shanghai Ren Ji hospital development garlic injection in 1972.This characteristic is prevalent in the fragrance book on Chinese herbal medicine class in book on Chinese herbal medicine, namely tcm prescription indicates those Chinese medicines of " under rear ", so effectively oral.The liposome of the invention sixties in last century is a kind of contributions to the mankind.It seems now not to be necessary.
The street cleaner hauled more and run faster: above-mentioned unsaturated thioesters, molecular weight is little, and maximum is also all less than 180, double bond, and chemical property is active, and become the street cleaner of load fat, glucose, Here it is occurs allicin reducing blood lipid, hypoglycemic molecule pharmacological mechanism clinically.
To sum up, unsaturated thioester becomes anti-various infection, reducing blood lipid, the important substance of blood sugar, therefore the saying having garlic to control all kinds of diseases and ailments among the people.
" rear under " of the traditional Chinese medical science, namely refers to fragrance book on Chinese herbal medicine, as peppermint, wrinkled giant hyssop, cassia twig, herba houttuyniae, Chinese anise etc., also increases a garlic now, has listed Chinese Pharmacopoeia in 2010 in.
Book on Chinese herbal medicine volatile oil 22 adds olefine aldehydr ketone 108, counts 130, accounts for 1012 13%, but do not look down upon them, because they play great pharmacological action.Volatile oil is generated by isoprene, but does not impose uniformity without examining individual cases, namely keto-aldehyde alkynes also can, as long as Small molecular double bond, namely strong oxidizer can kill pathogenic microorganisms.But from the evolution of the mankind, mammal and pathogenic microorganisms is struggled against, also need a methyl to be increased to ODN, on CpG island nucleic acid 5 ', strengthen immunologic function to excite the growth propagation of B, T cell when pathogenic microorganisms is invaded.(methacrylic thioesters) is selected by the mankind and mammal like this.Garlic contains three kinds of diallyl thioesters and three kinds of methacrylic thioesters, and this is the important molecule mechanism that garlic controls all kinds of diseases and ailments.Like this, garlic thioesters becomes once is the patron saint of life over 4.5 hundred million years; Also be the patron saint of the present and the future mankind and mammal!
Can imagine, hand can duty be washed, and food can cook well-done, prevents that illness finds its way in by the mouth to greatest extent, but people cannot accomplish that the air of people's scope of activities is all sterilized, that is people cannot avoid sucking pathogenic microorganisms because of breathing.Namely autumn-dryness disease is an example, whenever the time in late autumn, north strong cold air becomes to directly entering to reach the Yangtze river basin by North China Central China head, sometimes can have influence on area, Guangdong and Guangxi Provinces, cause people's cold cough, tracheitis etc. because dust in air is entrained with various pathogenic microorganisms (gasoloid).
There are two workers in certain hospital, suffers from rhinitis chronic, chronic bronchitis for one, and the treatment through many Grade A hospital more than ten years of two places, peaceful Shanghai is not cured, and another one suffers from 40 years rhinitis chronics, and in more than 40 year, two operations is not cured.But two people participate in development 2 wheat harvesting period of garlic injection for once 1970, rhinitis chronic, chronic bronchitis recovery occurs without treatment soon.When its reason is development garlic injection, breathes all day and be full of alliaceous air and heal.The rhinitis chronic patient of those bit stream green pus tears seeks help from me, gives garlic nasal drops and namely heals for one week, the valuable pharmacological effect of visible volatile oil.
Some traditional Chinese medical science fears the pungency of garlic, and garlic is irritant really, improper use, and skin can bubble.This garlic forcing Switzerland doctor to abandon their invention controls the method for rhinitis chronic.But we to have grasped early than Switzerland doctor in the seventies and have removed foamer, and got its pharmacological mechanism clear, use is safe.
Organic acid and alcohol
Organic acid 56, alcohol 58, add up to 114, accounting is slightly above 11%.
According to the Natural Medicine Chemistry 317 pages of Mei Li army chief editor record organic acid to enter in body after and cholesterol form compound and excrete, i.e. organic acid, has the effect of norcholesterol.
Containing chlorogenic acid in honeysuckle, be kind of a good Chinese medicine microbiotic, neat pier acid, glycyrrhizic acid and glucose can form glucoside.
Relevant problem:
Compound, it is nearly all compound that Chinese herbal medicine is cured the disease, and from the Treatise on Fevrile Diseases of Zhang Zhongjing, a kitchen has three taste medicines at least, normally 3-5 taste medicine, maximum reached at 7-8 tastes, and the medicine that Treatise on Fevrile Diseases pandect relates to only 80 pleasant impressions.To the modern times, the what is called that 8-9 taste medicine and even more medicine are formed is generous also very common, and the medicine related to reaches 535 tastes.The only taste soup of so-called ginseng is also wherein containing a large amount of effective constituent in fact, and modern confirmation, ginseng contains more than 30 plants panaxoside and tens of kinds of eneyne type organics, and it has very strong oxidisability.
Parent's film: it is kind of a complicated process that drug molecule enters in human body cell, at least wants cross-film 1-5 time, even also has 7-9 time, and with the combination of G-protein, visible cell film has like the bastion of iron.Doctor trained in Western medicine emphasize quiet note, quiet, rapidly and efficiently.But in fact many drug molecules are blocked in outside cell membrane, and the pathogenic microorganisms in virocyte is safe and sound in cell, so Western medicine is to pathogenic bacteria limited efficiency in virus, born of the same parents.And as herein say, the glucoside in Chinese herbal medicine, ester, volatile oil equal size are more than 80%, and they have amphiphilic, can enter in cell smoothly, reach to kill germ in born of the same parents, thus realize preventing disease theraping effect.
Synergy: from content of monomer, general only several milligram, even several microgram, but namely foregoing solely taste Ginseng Decoction has so numerous medicine with the panaxoside of similar performance, those reach the generous of 8-9 taste medicine still more, so, even if little from content of monomer, but what have in Chinese herbal medicine a series ofly has substantially mutually isostructural monomer and has identical pharmacological action, and namely this act synergistically.
And connection reaction, structure, the communication network mechanism of action of human body cell are very complicated, some cellular elements enters after cell is combined with G-protein, can excite the molecule of some cell, these molecules are the third molecule of deexcitation again, forms cascade reaction, the effect of drug molecule is made to amplify several times to tens times, even if so the drug molecule amount entering cell membrane is few, but under the help of cascade reaction, can play a big part.
Drug resistance: modern age, first nineteen twenty-eight Britain bacteriologist Fleming has found the first microbiotic-penicillin in the world, plays penicillin and starts application clinical, saved the life of countless patient to 1940.But widely using with penicillin, germ is gradually to which creating drug resistance.To the 1970's, the effect of penicillin is had a greatly reduced quality.Because western medicine antibiotics, the general 2-3 of its effective group, reach at most 4 or 5, and pathogenic microorganisms is in evolution, along with evolutionary process, it can adapt to antibiotic effective group singly, can adapt to completely through many decades, cause microbiotic drug effect to be lost.And in Chinese herbal medicine, there is not this problem, with common garlic, it contains thioester, triterpenoid saponin, also has numerous sulfide, and pathogenic microorganisms is difficult to adapt to so numerous groups.The anti-infection of garlic is found and uses existing more than 5000 years so far, and its anti-infectious effect remains unchanged.Be used for preventing and treating the numb apricot Shigao Tang of hay of pestilence with Zhang Zhongjing, still can be used to anti-avian influenza to today.Visible, Chinese herbal medicine adapts to the infection of various pathogenic microorganisms, formed in human body saponin particularly triterpenoid saponin, ester class particularly thioesters and volatilization wet goods thousands of, pathogenic microorganisms to its formed drug resistance be very difficulty.
In sum, Chinese medicine can solve the various virus infectionses that Western medicine is difficult to treat, the G such as in various born of the same parents, microorganism is as G-and staphylococcus aureus, mark tubercle bacillus
+medicine infects.
Need what mention to be safety issue, general formula involved in the present invention comprises as safrole, and existing report thinks that it can be carcinogenic, and therefore, the effective constituent obtained according to the present invention still needing to do animal experiment before clinical.
The following event of purposes of the present invention illustrates:
Whenever going deep into investigation folk prescription among the people, when the people cure, must collect complete herbal sample, band flowers and fruits band root, band rhizome, because this grass roots, rhizome medicine accounting is maximum; Flowers and fruits are also many, and they are organs of multiplication, and must store enough nutrition, energy and prevent the material of disease and pest, the normal growth for seedling is grown.
Distinguish stamen grass of meadow rue, infer with more than 10,000 the drug molecular structure formulas collected with reference to " China's book on Chinese herbal medicine " according to theory of biologic evolution: debate in stamen grass of meadow rue and be likely separated to similar 1 to the several biological alkali of jamaicin structure.As for glossy privet, can be separated in its kernel and obtain multiple similar volatile oil, unsaturated fatty acid to being separated in the capsule of weeping forsythia.
In addition fraxetin, moutan bark are all led containing glucoside material in addition, see " China's book on Chinese herbal medicine " 665 pages, and 10-826 page, 10-1293 page.
Find qinghaosu substitute products
It was reported that the plasmodium falciparum invading human brain produces drug resistance to qinghaosu.It is predictable that total oxygen esters medicine produces drug resistance, as Anti-HIV agents tenofovir.If one in the lactone 4 of qinghaosu, on the ring intramolecular lactone of 6 interdigits or 12 makes two thiolactone (R into
1sSR
2) that drug resistance can postpone.The key finding antimalarial is that plasmodium is worm or fungi, and the author thinks that plasmodium is fungi, fungi in this way, and that way is just just many.
Why can lepidium seed control myocarditis? lepidium seed exceeds the plant that knee is similar to wormwood artemisia outward, 2-3 returns winglike compound leaf, siliqua, faint yellow, there is folder film, film is had the seed eliminating brown, seed refers to a pressure with two mothers, see there is oil stain, Jian Dings Wei ma Ba wormwood artemisia, and (DecunainiaSophia) seed is exactly lepidium seed.Rear confirmation, lepidium seed can control myocarditis:
" selected of China's book on Chinese herbal medicine " 709 pages of lepidium seed hurdles: " lepidium seed contains sinapic acid, strophanthin, yellowish-white erysimoside ..., also containing volatile oil, containing glucosinolates in volatile oil, erucic acid, diallyl disulfide, linoleic acid, leukotrienes ... ".Present strophanthin as everybody knows, have cardiotonic, diallyl disulfide is strong oxidizer, has antiviral antibacterial action, and strophanthin and diallyl disulfide can control myocarditis, pericarditis and endocarditis just.
Claims (4)
1. come from a rapid screening method for the validity of curing the disease of biogenic material, it is characterized in that, analyze various biology of purifying, analyze its structure, have the material of following general formula all to can be used as effective constituent for medicine and composition thereof:
R
1(X)
nR
2
Wherein,
X is one or several in O, S, Se, N or C
n=1-5
R
1and R
2be selected from one of derivant of chain unsaturated hydrocarbon, cyclic hydrocarbon, aromatic hydrocarbon or glucoside respectively.
2. the rapid screening method coming from the validity of curing the disease of biogenic material according to claim 1, is characterized in that, described X is S or Se; N=1-3.
3. the rapid screening method coming from the validity of curing the disease of biogenic material according to claim 1, is characterized in that, described R
1=R
2.
4. the rapid screening method coming from the validity of curing the disease of biogenic material according to claim 1, is characterized in that, the derivant of described glucoside comprises oxygen glucoside, sulphur glucoside, nitrogen glucoside, carbon glucoside, glycosides displayed or saponin.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004505609A (en) * | 2000-04-03 | 2004-02-26 | オックスフォード グリコサイエンシズ（ユーケー） リミテッド | Nucleic acid molecules, polypeptides, and uses thereof including diagnosis and treatment of Alzheimer's disease |
| CN101040995A (en) * | 2006-03-20 | 2007-09-26 | 沈联慈 | Valid target of garlic oil and the application in preparing many kinds of medicine |
| CN102499912A (en) * | 2011-11-10 | 2012-06-20 | 沈德铭 | Garlic extract and preparation method thereof as well as application in preparation of drugs for resisting HIV-1 virus, tubercle bacillus and Toxoplasma gondii |
-
2014
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004505609A (en) * | 2000-04-03 | 2004-02-26 | オックスフォード グリコサイエンシズ（ユーケー） リミテッド | Nucleic acid molecules, polypeptides, and uses thereof including diagnosis and treatment of Alzheimer's disease |
| CN101040995A (en) * | 2006-03-20 | 2007-09-26 | 沈联慈 | Valid target of garlic oil and the application in preparing many kinds of medicine |
| CN102499912A (en) * | 2011-11-10 | 2012-06-20 | 沈德铭 | Garlic extract and preparation method thereof as well as application in preparation of drugs for resisting HIV-1 virus, tubercle bacillus and Toxoplasma gondii |
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