CN105330565A - Novel method for catalytically synthesizing cyanobenzene derivative through copper - Google Patents
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Abstract
The invention discloses a novel method for catalytically synthesizing a cyanobenzene derivative through copper. The method comprises the steps that a benzyl ether or benzaldehyde compound is used as a substrate and combined with a nitrogen source at certain temperature on the condition that copper salt is used as a catalyst to obtain the cyanobenzene derivative. Compared with traditional synthesis methods, the novel method includes only one step, the reaction time is short, the reaction condition is mild, and aftertreatment is simple. The substrate range is wide, both benzyl ether and benzaldehyde can be used as the substrate, it is not reported that ethers are used as the substrate for synthesizing a nitrile compound, no side reaction is produced when benzaldehyde is used as the substrate, and the product separation yield reaches 94% to the maximum degree.
Description
Technical field
The invention belongs to chemosynthesis, high-activity biological pharmaceutical intermediate study on the synthesis technical field, specifically a kind of synthetic method of benzonitrile derivative, i.e. the synthetic method of 2-(2-hydroxyethyl)-cyanobenzene and derivative thereof.
Background technology
Nitrile compounds is very important industrial chemicals, is widely used in the fields such as chemical industry, medicine, agricultural chemicals and biology, and at synthon and plastics, the quenching of plating, steel etc. are industrial also to be had and important effect.In the present invention, the important intermediate of concrete synthesized compound to be 2-(2-hydroxyethyl)-cyanobenzene and derivative thereof be synthetic drugs [o-bismuth (heterocycle) aryl]-[2-(m-two (heterocycle) aryl-pyrrolidine-1-base]-methyl ketone, this medicine is used as the antagonist of orexin receptor, plays an important role in the metabolism of organism.Meanwhile, this compound is also the important source material of synthesis 2-(sulfenyl) nicotine and (S)-2-(pyridine-4-is amino) propyl alcohol.Wherein the former is used as the inhibitor of 11HSD1, and 11HSD1 is the drug tar-get of diabetes and metabolic syndrome, at present at medicine with to be clinically all widely used.The latter, as the pharmaceutical intermediate preparing thrombin inhibitors, is widely used in medical, and thrombin inhibitors, as the important medicine for the treatment of blood coagulation and cardiovascular disorder, is also widely used in clinical treatment.In a word, 2-(2-the hydroxyethyl)-cyanobenzene prepared by our synthetic method and derivative thereof are very important medicine intermediates.
In synthesis nitrile compounds, have a lot of chemist both at home and abroad to this has been research, almost each year has similar research to be in the news.In the middle of the research of synthesis nitrile compounds, substrate extremely has popularity, but also come with some shortcomings in synthetic method.Report respectively from benzyl halide and aldehyde compound 2010 and 2012, all synthesize cyano group using sodiumazide as nitrogenous source, although productive rate all can reach more than 90%, need with the higher sodiumazide of toxicity.2013, M.Bhanage group was using phenylcarbinol as substrate, and ammonium formiate as nitrogenous source, thus achieves research alcohol compound being converted into the nitrile compounds with cyano group, but this synthetic method need to carry out at a higher temperature and the reaction times longer.Within 2014, certain chemical group external proposes the route of synthesis 2-(2-hydroxyethyl)-cyanobenzene and derivative thereof, but synthetic route is longer, needs 4 steps just can complete.
At home, the pyronine seminar research in this regard of Peking University is particularly outstanding, within 2012, they have developed from toluene, nitrile compounds has been collectively referred to as under the promotion of Cu, they have attempted again with the alkene with aryl as raw material is to synthesize cyano group subsequently, with trimethyl silicon based nitrine for nitrogenous source, and achieve higher yield.After this, they have also synthesized cyano group from alkynyl, and productive rate is also up to more than 80%; But the by product that this reaction produces is more, does not meet the theory of Atom economy.They have studied again and go out to send synthesis containing heteroatomic heterogeneous ring compound from having subsequently.But, just synthesis substrate, they report before still not breaking through some, this has certain limitation for industrial application.
Make a general survey of the report of above-mentioned mentioned synthetic method, all there are some areas for improvement, as serious in environmental pollution, reaction substrate not extensively, reactions steps is more, by product is many and severe reaction conditions etc.Although reaction substrate has arene compounds, aldehydes, alcohols, heterocyclic etc., from ether compound synthesis nitrile compounds but still beyond example.Further, exploration discovery in us constantly experiment, this synthetic method is equally applicable to compound of benzaldehyde category and directly prepares cyanobenzene compounds.Therefore, the present invention opens a new route of synthesis in the synthesis being applied to nitrile compounds, has widened the substrate spectrum synthesizing nitrile compounds in the industrial production further, is conducive to preparing this important industrial chemicals.
Summary of the invention
The deficiency that the present invention is directed to above-mentioned synthetic method provides a kind of novel method for synthesizing of benzonitrile derivative, that one catalyzes and synthesizes benzonitrile derivative by copper, take ether compound as substrate, using trimethyl silicon based nitrine as nitrogenous source, avoid the sodiumazide that toxicity is larger, use base metal copper as catalyzer, reaction conditions is gentle, and the reaction times is short and reaction only needs a step namely to complete.Further, exploration discovery in us constantly experiment, this synthetic method is equally applicable to compound of benzaldehyde category and directly prepares cyanobenzene compounds.Particular content is using benzylic ether or compound of benzaldehyde category as substrate, under the existence condition of nitrogenous source, prepares cyanobenzene compounds by mantoquita catalysis.
Concrete synthetic route is as follows:
Wherein R
1for hydrogen, methyl, halogen X (X=F, Cl, Br), the tertiary butyl, methoxyl group or phenyl ring, R
2for methyl or phenyl ring;
R
3for methoxyl group, nitro, phenyl ring, halogen X (X=Br, I).
For achieving the above object, the technical solution used in the present invention is: respectively with benzylic ether or compound of benzaldehyde category for substrate, trimethyl silicon based nitrine be example as nitrogenous source, mantoquita is catalyzer, at a certain temperature obtained a series of benzonitrile derivative.Wherein the mol ratio of mantoquita and nitrogenous source is 1:1 ~ 15, and the mol ratio of substrate and nitrogenous source and mantoquita is respectively 1:1 ~ 15 and 1:1 ~ 15.
It is a kind of in a hydration neutralized verdigris, cuprous bromide, cupric bromide, cupric chloride, anhydrous cupric sulfate, copper powder or its more than one multiple mixture that described mantoquita is selected from; Be preferably cupric bromide.
Described nitrogenous source is the one in p-toluene sulfonyt azide, trimethyl silicon based nitrine, sodiumazide, trimethyl silicon based diazomethane; Be preferably trimethyl silicon based nitrine.
Above, in described mantoquita, the copper of cuprous bromide is a valence state, and the copper in copper powder is zero-valent state, and remaining copper is all divalent state.
Described temperature of reaction is 60 ~ 120 DEG C, and the reaction times is 2 ~ 12 hours, is preferably 80 DEG C.
The inventive method is preferably:
For formula (1) step: benzylic ether is added in reaction solvent and dissolves, add a certain amount of trimethyl silicon based nitrine subsequently, at 80 DEG C, preheating 2 minutes, then adds a certain amount of copper salt catalyst, finally puts into the oil bath pan reacting by heating 2 ~ 12 hours of 80 DEG C; After reaction terminates, system is cooled to room temperature, filters, be then extracted with ethyl acetate, more respectively with water and saturated common salt washing; The organic layer drying obtained, concentrated after by column chromatography, obtain pure compound: 2-(2-hydroxyethyl)-cyanobenzene.
For formula (2) step: phenyl aldehyde is added in reaction solvent and dissolves, add a certain amount of trimethyl silicon based nitrine subsequently, at 80 DEG C, preheating 2 minutes, then adds a certain amount of copper salt catalyst, finally puts into the oil bath pan reacting by heating 2 ~ 10 hours of 80 DEG C; After reaction terminates, system is cooled to room temperature, filters, be then extracted with ethyl acetate, more respectively with water and saturated common salt washing; The organic layer drying obtained, concentrated after by column chromatography, obtain pure compound: cyanobenzene.
Described reaction solvent is the one in toluene, methylene dichloride, tetrahydrofuran (THF), ethyl acetate, propyl acetate, acetone, butanone, acetonitrile, ether, benzene, dimethylbenzene, trimethylbenzene, normal hexane.
The invention has the beneficial effects as follows:
1, this invention exploits with benzyl ethers compounds is starting raw material, does not all use in synthesis nitrile compounds reported before.
2, the present invention compares with synthetic method in the past, and reactions steps only has a step, and the reaction times is shorter, and reaction conditions is gentle and aftertreatment is simple.
3, the substrate spectrum of the present invention's use is wider, and comprise benzylic ether and benzaldehydes, and occur without side reaction as during substrate reactions at benzaldehydes, the separation yield of product is up to 94%.
Accompanying drawing explanation
The hydrogen spectrum of Fig. 1 (a) 2-(2-hydroxyethyl) cyanobenzene prepared by embodiment 1, (b) is carbon spectrum;
The hydrogen spectrum of Fig. 2 (a) the fluoro-2-of 5-(2-hydroxyethyl) cyanobenzene prepared by embodiment 2, (b) is carbon spectrum;
The hydrogen spectrum of Fig. 3 (a) the fluoro-2-of 6-(2-hydroxyethyl) cyanobenzene prepared by embodiment 3, (b) is carbon spectrum;
The hydrogen spectrum of Fig. 4 (a) the chloro-2-of 5-(2-hydroxyethyl) cyanobenzene prepared by embodiment 4, (b) is carbon spectrum;
The hydrogen spectrum of Fig. 5 (a) the chloro-2-of 6-(2-hydroxyethyl) cyanobenzene prepared by embodiment 5, (b) is carbon spectrum;
The hydrogen spectrum of Fig. 6 (a) the bromo-2-of 5-(2-hydroxyethyl) cyanobenzene prepared by embodiment 6, (b) is carbon spectrum;
The hydrogen spectrum of Fig. 7 (a) the bromo-2-of 6-(2-hydroxyethyl) cyanobenzene prepared by embodiment 7, (b) is carbon spectrum;
The hydrogen spectrum of Fig. 8 (a) 2-(1-hydroxyl-2-hydroxypropyl) cyanobenzene prepared by embodiment 8, (b) is carbon spectrum;
The hydrogen spectrum of Fig. 9 (a) 3-(2-hydroxypropyl) cyanobenzene prepared by embodiment 9, (b) is carbon spectrum;
The hydrogen spectrum of Figure 10 (a) 2-(2-hydroxyethyl) 5-methyl benzonitrile prepared by embodiment 10, (b) is carbon spectrum;
The hydrogen spectrum of Figure 11 (a) 2-(2-hydroxyethyl) 6-methyl benzonitrile prepared by embodiment 11, (b) is carbon spectrum;
The hydrogen spectrum of Figure 12 (a) 2-(2-hydroxyethyl) 3,6-dimethyl benzene formonitrile HCN prepared by embodiment 12, (b) is carbon spectrum;
The hydrogen spectrum of Figure 13 (a) the 5-tertiary butyl-2-(2-hydroxyethyl) cyanobenzene prepared by embodiment 13, (b) is carbon spectrum;
The hydrogen spectrum of Figure 14 (a) 5-methoxyl group-2-(2-hydroxyethyl) cyanobenzene prepared by embodiment 14, (b) is carbon spectrum;
The hydrogen spectrum of Figure 15 (a) 5-methoxyl group-2-(2-hydroxyethyl) cyanobenzene prepared by embodiment 15, (b) is carbon spectrum;
The hydrogen spectrum of Figure 16 (a) 1-(2-hydroxyethyl) 2-naphthyl cyanide prepared by embodiment 16, (b) is carbon spectrum;
The hydrogen spectrum of Figure 17 (a) 4-methoxy benzonitrile prepared by embodiment 17, (b) is carbon spectrum;
The hydrogen spectrum of Figure 18 (a) 2-methoxy benzonitrile prepared by embodiment 18, (b) is carbon spectrum;
The hydrogen spectrum of Figure 19 (a) 2-nitrobenzonitrile prepared by embodiment 19, (b) is carbon spectrum;
The hydrogen spectrum of Figure 20 (a) 3-nitrobenzonitrile prepared by embodiment 20, (b) is carbon spectrum;
The hydrogen spectrum of Figure 21 (a) 4-nitrobenzonitrile prepared by embodiment 21, (b) is carbon spectrum;
The hydrogen spectrum of Figure 22 (a) 2-naphthyl cyanide prepared by embodiment 22, (b) is carbon spectrum;
The hydrogen spectrum of Figure 23 (a) 4-bromobenzylcyanide prepared by embodiment 23, (b) is carbon spectrum;
The hydrogen spectrum of Figure 24 (a) 2-iodobenzene formonitrile HCN prepared by embodiment 24, (b) is carbon spectrum.
Embodiment
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1:
Add in a round-bottomed flask heterochromatic full (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), stirs 1-2 minute, and then adds CuBr in the heating module of 80 DEG C
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain product 2-(2-hydroxyethyl) cyanobenzene by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 85%.
As shown in Fig. 1 (a), the hydrogen spectrum of 2-prepared by embodiment 1 (2-hydroxyethyl) cyanobenzene:
1hNMR (500MHz, CDCl
3) δ 7.64 (d, J=7.7Hz, 1H), 7.55 (td, J=7.7,1.1Hz, 1H), 7.42 (d, J=7.8Hz, 1H), 7.34 (t, J=7.6Hz, 1H), 3.93 (t, J=6.5Hz, 2H), 3.11 (t, J=6.5Hz, 2H), 2.06 (s, 1H).
As shown in Fig. 1 (b), the carbon spectrum of 2-prepared by embodiment 1 (2-hydroxyethyl) cyanobenzene:
13cNMR (126MHz, CDCl
3) δ 142.82,132.88,132.82,130.37,127.01,118.12,112.83,62.53,37.78.
Embodiment 2:
In a round-bottomed flask, add 5-fluorine heterochromatic full (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), stirs 1-2 minute, and then adds CuBr in the heating module of 80 DEG C
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain the fluoro-2-of product 5-(2-hydroxyethyl) cyanobenzene by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 80%.
As shown in Fig. 2 (a), the hydrogen spectrum of the fluoro-2-of 5-(2-hydroxyethyl) cyanobenzene prepared by embodiment 2:
1hNMR (500MHz, CDCl
3) δ 7.42 (dd, J=8.6,5.3Hz, 1H), 7.36 (dd, J=8.0,2.7Hz, 1H), 7.28 (td, J=8.2,2.7Hz, 1H), 3.94 (t, J=6.4Hz, 2H), 3.10 (t, J=6.4Hz, 2H), 1.77 (s, 1H).
As shown in Fig. 2 (b), the carbon spectrum of the fluoro-2-of 5-(2-hydroxyethyl) cyanobenzene prepared by embodiment 2:
13cNMR (126MHz, CDCl
3) δ 161.76,159.79,138.95,138.92,132.29,132.23,120.55,120.39,119.50,119.31,62.53,62.52,36.97.
Mass-spectrometric data is: HRMS (ESI) CalcdforC
9h
9fNO (M+H
+): 166.0668, found, 166.0666.
Embodiment 3:
In a round-bottomed flask, add 6-fluorine heterochromatic full (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), stirs 1-2 minute, and then adds CuBr in the heating module of 80 DEG C
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain the fluoro-2-of product 8-(2-hydroxyethyl) cyanobenzene by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 80%.
As shown in Fig. 3 (a), the hydrogen spectrum of the fluoro-2-of 6-(2-hydroxyethyl) cyanobenzene prepared by embodiment 3:
1hNMR (500MHz, CDCl
3) δ 7.65 (dd, J=8.6,5.5Hz, 1H), 7.15 (dd, J=9.2,2.5Hz, 1H), 7.04 (td, J=8.3,2.5Hz, 1H), 3.96 (t, J=6.3Hz, 2H), 3.16 – 2.99 (m, 2H), 1.69 (d, J=6.2Hz, 1H).
As shown in Fig. 3 (a), the carbon spectrum of the fluoro-2-of 6-(2-hydroxyethyl) cyanobenzene prepared by embodiment 3:
13cNMR (126MHz, CDCl
3) δ 165.95,163.91,146.42,146.35,135.16,135.09,117.90,117.72,117.45,114.87,114.69,62.21,37.63,37.62.
Mass-spectrometric data is: HRMS (ESI) CalcdforC
9h
8fNONa (M+Na
+): 188.0488, found, 188.0484.
Embodiment 4:
In a round-bottomed flask, add 5-chlorine heterochromatic full (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), stirs 1-2 minute, and then adds CuBr in the heating module of 80 DEG C
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain the chloro-2-of product 5-(2-hydroxyethyl) cyanobenzene by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 70%.
As shown in Fig. 4 (a), the hydrogen spectrum of the chloro-2-of 5-(2-hydroxyethyl) cyanobenzene prepared by embodiment 4:
1hNMR (500MHz, CDCl
3) δ 7.63 (d, J=2.2Hz, 1H), 7.53 (dd, J=8.4,2.2Hz, 1H), 7.38 (d, J=8.4Hz, 1H), 3.94 (t, J=6.4Hz, 2H), 3.09 (t, J=6.4Hz, 2H), 1.77 (s, 1H).
As shown in Fig. 4 (b), the carbon spectrum of the chloro-2-of 5-(2-hydroxyethyl) cyanobenzene prepared by embodiment 4:
13cNMR (126MHz, CDCl
3) δ 141.41,133.12,132.93,132.32,131.77,116.87,114.35,62.37,37.14.
Mass-spectrometric data is: HRMS (ESI) CalcdforC
9h
8clNONa (M+Na
+): 204.0192, found, 204.0189.
Embodiment 5:
In a round-bottomed flask, add 6-chlorine heterochromatic full (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), stirs 1-2 minute, and then adds CuBr in the heating module of 80 DEG C
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain the chloro-2-of product 6-(2-hydroxyethyl) cyanobenzene by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 65%.
As shown in Fig. 5 (a), the hydrogen spectrum of the chloro-2-of 6-(2-hydroxyethyl) cyanobenzene prepared by embodiment 5:
1hNMR (500MHz, CDCl
3) δ 7.58 (d, J=8.3Hz, 1H), 7.43 (d, J=2.0Hz, 1H), 7.33 (dd, J=8.3,2.0Hz, 1H), 3.94 (dd, J=7.8,4.8Hz, 2H), 3.07 (t, J=6.3Hz, 2H), 1.85 (d, J=6.7Hz, 1H).
As shown in Fig. 5 (b), the carbon spectrum of the chloro-2-of 6-(2-hydroxyethyl) cyanobenzene prepared by embodiment 5:
13cNMR (126MHz, CDCl
3) δ 144.81,139.38,133.91,130.72,127.55,117.44,111.28,62.21,37.49.
Mass-spectrometric data is: HRMS (ESI) CalcdforC
9h
8clNONa (M+Na
+): 204.0192, found, 204.0192.
Embodiment 6:
In a round-bottomed flask, add 5-bromine heterochromatic full (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), stirs 1-2 minute, and then adds CuBr in the heating module of 80 DEG C
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain the bromo-2-of product 5-(2-hydroxyethyl) cyanobenzene by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 60%.
As shown in Fig. 6 (a), the hydrogen spectrum of the bromo-2-of 5-(2-hydroxyethyl) cyanobenzene prepared by embodiment 6:
1hNMR (500MHz, CDCl
3) δ 7.78 (d, J=2.1Hz, 1H), 7.68 (dd, J=8.3,2.1Hz, 1H), 7.32 (d, J=8.3Hz, 1H), 3.94 (t, J=6.4Hz, 2H), 3.07 (t, J=6.4Hz, 2H), 1.79 (s, 1H).
As shown in Fig. 6 (b), the carbon spectrum of the bromo-2-of 5-(2-hydroxyethyl) cyanobenzene prepared by embodiment 6:
13cNMR (126MHz, CDCl
3) δ 141.89,136.02,135.18,131.97,120.36,116.73,114.69,62.29,37.22.
Mass-spectrometric data is: HRMS (ESI) CalcdforC
9h
9brNO (M+H
+): 225.9868, found, 225.9865.
Embodiment 7
In a round-bottomed flask, add 6-bromine heterochromatic full (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), stirs 1-2 minute, and then adds CuBr in the heating module of 80 DEG C
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain the bromo-2-of product 6-(2-hydroxyethyl) cyanobenzene by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 87%.
As shown in Fig. 7 (a), the hydrogen spectrum of the bromo-2-of 6-(2-hydroxyethyl) cyanobenzene prepared by embodiment 7:
1hNMR (500MHz, CDCl
3) δ 7.62 (s, 1H), 7.52 (d, J=1.4Hz, 2H), 3.99 – 3.96 (m, 2H), 3.09 (t, J=6.3Hz, 2H), 1.66 (s, 1H).
As shown in Fig. 7 (b), the carbon spectrum of the bromo-2-of 6-(2-hydroxyethyl) cyanobenzene prepared by embodiment 7:
13cNMR (126MHz, CDCl
3) δ 144.78,133.90,133.65,130.49,127.91,117.47,111.81,62.26,37.44.
Mass-spectrometric data is: HRMS (ESI) CalcdforC
9h
9brNO (M+H
+): 225.9868, found, 225.9876.
Embodiment 8:
In a round-bottomed flask, add 4-methyl heterochromatic full (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), stirs 1-2 minute, and then adds CuBr in the heating module of 80 DEG C
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain product 2-(1-hydroxyl-2-hydroxypropyl) cyanobenzene by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 50%.
As shown in Fig. 8 (a), the hydrogen spectrum of 2-prepared by embodiment 8 (1-hydroxyl-2-hydroxypropyl) cyanobenzene:
1hNMR (500MHz, CDCl
3) δ 7.57 (dd, J=7.7,1.1Hz, 1H), 7.50 (td, J=7.8,1.3Hz, 1H), 7.35 (d, J=7.9Hz, 1H), 7.25 (td, J=7.6,1.0Hz, 1H), 3.73 (d, J=6.6Hz, 2H), 3.37 (dd, J=13.6,6.8Hz, 1H), 1.64 (s, 1H), 1.27 (d, J=7.0Hz, 3H).
As shown in Fig. 8 (b), the carbon spectrum of 2-prepared by embodiment 8 (1-hydroxyl-2-hydroxypropyl) cyanobenzene:
13cNMR (126MHz, CDCl
3) δ 146.83,132.02,132.01,125.96,125.94,117.17,111.85,66.52,39.52,16.12.
Mass-spectrometric data is: HRMS (ESI) CalcdforC
10h
12nO (M+H
+): 162.0919, found, 162.0926.
Embodiment 9
In a round-bottomed flask, add 3-methyl heterochromatic full (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), stirs 1-2 minute, and then adds CuBr in the heating module of 80 DEG C
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain product 3-(2-hydroxypropyl) cyanobenzene by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 67%.
As shown in Fig. 9 (a), the hydrogen spectrum of 3-prepared by embodiment 9 (2-hydroxypropyl) cyanobenzene:
1hNMR (500MHz, CDCl
3) δ 7.66 (dd, J=7.7,1.1Hz, 1H), 7.56 (td, J=7.7,1.3Hz, 1H), 7.43 – 7.39 (m, 1H), 7.36 (td, J=7.6,1.1Hz, 1H), 4.16 (ddd, J=7.8,6.2,4.8Hz, 1H), 3.01 (ddd, J=21.6,13.7,6.3Hz, 2H), 1.68 (s, 1H), 1.32 (d, J=6.2Hz, 3H).
As shown in Fig. 9 (b), the carbon spectrum of 3-prepared by embodiment 9 (2-hydroxypropyl) cyanobenzene:
13cNMR (126MHz, CDCl
3) δ 142.71,132.90,132.70,130.79,127.02,118.30,113.10,68.33,44.03,23.26.
Mass-spectrometric data is: HRMS (ESI) CalcdforC
10h
12nO (M+H
+): 162.0919, found, 162.0927.
Embodiment 10
In a round-bottomed flask, add 7-methyl heterochromatic full (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), stirs 1-2 minute, and then adds CuBr in the heating module of 80 DEG C
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain product 2-(2-hydroxyethyl) 5-methyl benzonitrile by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 60%.
As shown in Figure 10 (a), the hydrogen spectrum of 2-prepared by embodiment 10 (2-hydroxyethyl) 5-methyl benzonitrile:
1hNMR (500MHz, CDCl
3) δ 7.44 (s, 1H), 7.34 (dd, J=7.9,1.1Hz, 1H), 7.28 (d, J=7.9Hz, 1H), 3.90 (t, J=6.5Hz, 2H), 3.05 (t, J=6.5Hz, 2H), 2.35 (s, 3H), 1.77 (s, 1H).
As shown in Figure 10 (b), the carbon spectrum of 2-prepared by embodiment 10 (2-hydroxyethyl) 5-methyl benzonitrile:
13cNMR (126MHz, CDCl
3) δ 139.67,137.05,133.77,133.15,130.25,118.30,112.62,62.72,37.33,20.69.
Mass-spectrometric data is: HRMS (ESI) CalcdforC
10h
12nO (M+H
+): 162.0919, found, 162.0912.
Embodiment 11:
In a round-bottomed flask, add 8-methyl heterochromatic full (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), stirs 1-2 minute, and then adds CuBr in the heating module of 80 DEG C
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain product 2-(2-hydroxyethyl) 6-methyl benzonitrile by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 70%.
As shown in Figure 11 (a), the hydrogen spectrum of 2-prepared by embodiment 11 (2-hydroxyethyl) 6-methyl benzonitrile:
1hNMR (500MHz, CDCl
3) δ 7.52 (d, J=7.9Hz, 1H), 7.20 (s, 1H), 7.13 (d, J=7.9Hz, 1H), 3.96 – 3.84 (m, 2H), 3.10 – 2.96 (m, 2H), 2.43 (dd, J=60.8,42.4Hz, 3H), 2.07 (d, J=27.5Hz, 1H).
As shown in Figure 11 (b), the carbon spectrum of 2-prepared by embodiment 11 (2-hydroxyethyl) 6-methyl benzonitrile:
13cNMR (126MHz, CDCl
3) δ 143.79,142.60,132.79,132.32,131.15,128.19,127.89,127.50,118.50,109.67,62.62,62.60,38.08,37.74,21.83,20.87.
Mass-spectrometric data is: HRMS (ESI) CalcdforC
10h
12nO (M+H
+): 162.0919, found, 162.0912.
Embodiment 12:
In a round-bottomed flask, add 5,8-dimethyl heterochromatic full (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), stirs 1-2 minute, and then adds CuBr in the heating module of 80 DEG C
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, product 2-(2-hydroxyethyl) 3 can be obtained by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, 6-dimethyl benzene formonitrile HCN, yield is 38%.
As shown in Figure 12 (a), the hydrogen spectrum of 2-prepared by embodiment 12 (2-hydroxyethyl) 3,6-dimethyl benzene formonitrile HCN:
1hNMR (500MHz, CDCl
3) δ 7.26 (d, J=7.8Hz, 1H), 7.08 (d, J=7.8Hz, 1H), 3.88 (t, J=7.0Hz, 2H), 3.15 (t, J=7.0Hz, 2H), 2.50 (s, 3H), 2.36 (s, 3H), 1.79 (s, 1H).
As shown in Figure 12 (b), the carbon spectrum of 2-prepared by embodiment 12 (2-hydroxyethyl) 3,6-dimethyl benzene formonitrile HCN:
13cNMR (126MHz, CDCl
3) δ 140.57,140.08,135.06,134.39,128.12,117.88,114.02,62.09,35.34,20.59,19.39.
Mass-spectrometric data is: HRMS (ESI) CalcdforC
11h
14nO (M+H
+): 176.1075, found, 176.1074.
Embodiment 13:
In a round-bottomed flask, add the 7-tertiary butyl heterochromatic full (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), stirs 1-2 minute, and then adds CuBr in the heating module of 80 DEG C
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain the product 5-tertiary butyl-2-(2-hydroxyethyl) cyanobenzene by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 68%.
As shown in Figure 13 (a), the hydrogen spectrum of the 5-tertiary butyl-2-(2-hydroxyethyl) cyanobenzene prepared by embodiment 13:
1hNMR (500MHz, CDCl
3) δ 7.66 (d, J=2.1Hz, 1H), 7.58 (dd, J=8.2,2.1Hz, 1H), 7.35 (d, J=8.2Hz, 1H), 3.95 (t, J=6.5Hz, 2H), 3.09 (t, J=6.5Hz, 2H), 1.66 (s, 1H), 1.34 (s, 9H).
As shown in Figure 13 (b), the carbon spectrum of the 5-tertiary butyl-2-(2-hydroxyethyl) cyanobenzene prepared by embodiment 13:
13cNMR (126MHz, CDCl
3) δ 150.37,139.59,130.20,130.11,129.85,118.62,112.48,62.72,37.27,34.60,31.05.
Mass-spectrometric data is: HRMS (ESI) CalcdforC
13h
18nO (M+H
+): 204.1388, found, 204.1394.
Embodiment 14:
In a round-bottomed flask, add 7-methoxyl group heterochromatic full (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), stirs 1-2 minute, and then adds CuBr in the heating module of 80 DEG C
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain product 5-methoxyl group-2-(2-hydroxyethyl) cyanobenzene by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 64%.
As shown in Figure 14 (a), the hydrogen spectrum of 5-methoxyl group-2-(2-hydroxyethyl) cyanobenzene prepared by embodiment 14:
1hNMR (500MHz, CDCl
3) δ 7.34 (d, J=2.1Hz, 1H), 7.05 (dd, J=8.3,2.1Hz, 1H), 6.77 (d, J=8.3Hz, 1H), 3.80 (s, 2H), 3.74 (t, J=6.5Hz, 2H), 2.70 (t, J=6.5Hz, 2H), 1.60 (s, 1H).
As shown in Figure 14 (b), the carbon spectrum of 5-methoxyl group-2-(2-hydroxyethyl) cyanobenzene prepared by embodiment 14:
13cNMR (126MHz, CDCl
3) δ 153.48,132.66,131.17,128.00,112.99,110.97,110.60,62.49,55.25,36.82.
Mass-spectrometric data is: HRMS (ESI) CalcdforC
10h
12nO
2(M+H
+): 178.0868, found, 178.0854.
Embodiment 15:
3 are added in a round-bottomed flask, 4-dihydro-1H-benzo [h] heterochromatic full (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), in the heating module of 80 DEG C, stir 1-2 minute, and then add CuBr
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain product 1-(2-hydroxyethyl) 1-naphthyl cyanide by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 43%.
As shown in Figure 15 (a), the hydrogen spectrum of 5-methoxyl group-2-(2-hydroxyethyl) cyanobenzene prepared by embodiment 15:
1hNMR (500MHz, CDCl
3) δ 8.22 (d, J=8.4Hz, 1H), 8.01 (d, J=8.4Hz, 1H), 7.89 (d, J=8.1Hz, 1H), 7.70 – 7.65 (m, 1H), 7.57 (t, J=7.5Hz, 1H), 7.48 (t, J=7.0Hz, 1H), 4.03 (t, J=6.5Hz, 2H), 3.31 (t, J=6.5Hz, 2H), 1.69 (s, 1H).
As shown in Figure 15 (b), the carbon spectrum of 5-methoxyl group-2-(2-hydroxyethyl) cyanobenzene prepared by embodiment 15:
13cNMR (126MHz, CDCl
3) δ 143.74,132.90,131.65,128.69,128.44,127.33,127.00,125.11,117.07,109.79,62.86,38.61.
Mass-spectrometric data is: HRMS (ESI) CalcdforC
13h
12nO (M+H
+): 198.0919, found, 198.0913.
Embodiment 16:
1 is added in a round-bottomed flask, 4-dihydro-2H-benzo [f] heterochromatic full (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), in the heating module of 80 DEG C, stir 1-2 minute, and then add CuBr
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain product 1-(2-hydroxyethyl) 2-naphthyl cyanide by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 46%.
As shown in Figure 16 (a), the hydrogen spectrum of 1-prepared by embodiment 16 (2-hydroxyethyl) 2-naphthyl cyanide:
1hNMR (500MHz, CDCl
3) δ 8.18 (dd, J=5.4,4.2Hz, 1H), 7.91 – 7.87 (m, 1H), 7.80 (d, J=8.5Hz, 1H), 7.66 – 7.62 (m, 1H), 7.59 (d, J=8.5Hz, 1H), 4.03 (t, J=6.9Hz, 1H), 4.03 (t, J=6.9Hz, 2H), 3.64 (t, J=6.9Hz, 2H), 1.83 (s, 1H).
As shown in Figure 16 (b), the carbon spectrum of 1-prepared by embodiment 16 (2-hydroxyethyl) 2-naphthyl cyanide:
13cNMR (126MHz, CDCl
3) δ 142.00,135.08,131.49,129.01,128.64,128.11,127.73,126.66,124.81,77.32,77.06,76.81,62.83,34.83.
Mass-spectrometric data is: HRMS (ESI) CalcdforC
13h
11nONa (M+Na
+): 220.0738, found, 198.0913.
Embodiment 17
In a round-bottomed flask, add 4-methoxybenzaldehyde (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), in the heating module of 80 DEG C, stir 1-2 minute, and then add CuBr
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain product 4-methoxy benzonitrile by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 94%.
As shown in Figure 17 (a), the hydrogen spectrum of 4-methoxy benzonitrile prepared by embodiment 17:
1hNMR (500MHz, CDCl
3) δ 7.59 (d, J=8.9Hz, 2H), 6.95 (d, J=8.9Hz, 2H), 3.86 (s, 3H).
As shown in Figure 17 (b), the carbon spectrum of 4-methoxy benzonitrile prepared by embodiment 17:
13cNMR (126MHz, CDCl
3) δ 162.86,133.99,119.25,114.76,103.97,77.32,77.06,76.81,55.56.
Embodiment 18
In a round-bottomed flask, add Benzaldehyde,2-methoxy (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), in the heating module of 80 DEG C, stir 1-2 minute, and then add CuBr
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain product 2-methoxy benzonitrile by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 76%.
As shown in Figure 18 (a), the hydrogen spectrum of 2-methoxy benzonitrile prepared by embodiment 18:
1hNMR (500MHz, CDCl
3) δ 7.67 – 7.52 (m, 2H), 7.04 – 6.85 (m, 2H), 3.93 (d, J=4.5Hz, 3H).
As shown in Figure 18 (b), the carbon spectrum of 2-methoxy benzonitrile prepared by embodiment 18:
13cNMR (126MHz, CDCl
3) δ 161.25,137.28,135.85,134.42,133.78,120.78,113.06,111.29,56.01.
Embodiment 19:
In a round-bottomed flask, add 2-nitrobenzaldehyde (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), in the heating module of 80 DEG C, stir 1-2 minute, and then add CuBr
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain product 2-nitrobenzonitrile by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 74%.
As shown in Figure 19 (a), the hydrogen spectrum of 2-nitrobenzonitrile prepared by embodiment 19:
1hNMR (500MHz, CDCl
3) δ 8.36 (dd, J=6.1,3.4Hz, 1H), 7.98 – 7.93 (m, 1H), 7.89 – 7.83 (m, 2H).
As shown in Figure 19 (b), the carbon spectrum of 2-nitrobenzonitrile prepared by embodiment 19:
13cNMR (126MHz, CDCl
3) δ 135.64,134.37,133.76,125.61,114.98,108.10.
. embodiment 20:
In a round-bottomed flask, add 3-nitrobenzaldehyde (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), in the heating module of 80 DEG C, stir 1-2 minute, and then add CuBr
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain product 3-nitrobenzonitrile by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 85%.
As shown in Figure 20 (a), the hydrogen spectrum of 3-nitrobenzonitrile prepared by embodiment 20:
1hNMR (500MHz, CDCl
3) δ 8.56 – 8.53 (m, 1H), 8.50 – 8.47 (m, 1H), 8.01 (d, J=7.7Hz, 1H), 7.75 (t, J=8.0Hz, 1H).
As shown in Figure 20 (b), the carbon spectrum of 3-nitrobenzonitrile prepared by embodiment 20:
13cNMR (126MHz, CDCl
3) δ 137.61,130.68,127.55,127.25,116.54,114.17.
Embodiment 21:
In a round-bottomed flask, add 4-nitrobenzaldehyde (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), in the heating module of 80 DEG C, stir 1-2 minute, and then add CuBr
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain product 4-nitrobenzonitrile by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 90%.
As shown in Figure 21 (a), the hydrogen spectrum of 4-nitrobenzonitrile prepared by embodiment 21:
1hNMR (500MHz, CDCl
3) δ 8.39 – 8.35 (m, 2H), 7.93 – 7.86 (m, 2H).
As shown in Figure 21 (b), the carbon spectrum of 4-nitrobenzonitrile prepared by embodiment 21:
13cNMR (126MHz, CDCl
3) δ 133.50,124.32,118.36,116.82.
Embodiment 22
In a round-bottomed flask, add 2-naphthaldehyde (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), in the heating module of 80 DEG C, stir 1-2 minute, and then add CuBr
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain product 2-naphthyl cyanide by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 84%.
As shown in Figure 22 (a), the hydrogen spectrum of 2-naphthyl cyanide prepared by embodiment 22:
1hNMR (500MHz, CDCl
3) δ 8.22 (s, 1H), 7.93 – 7.87 (m, 3H), 7.67 – 7.57 (m, 3H).
As shown in Figure 22 (b), the carbon spectrum of 2-naphthyl cyanide prepared by embodiment 22:
13cNMR (126MHz, CDCl
3) δ 134.66,134.17,132.26,129.21,129.06,128.43,128.07,127.67,126.36,119.27,109.40.
Embodiment 23:
In a round-bottomed flask, add 4-bromobenzaldehyde (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), in the heating module of 80 DEG C, stir 1-2 minute, and then add CuBr
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain product 4-bromobenzylcyanide by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 68%.
As shown in Figure 23 (a), the hydrogen spectrum of 4-bromobenzaldehyde prepared by embodiment 23:
1hNMR (500MHz, CDCl
3) δ 7.63 (dt, J=7.4,3.7Hz, 2H), 7.54 – 7.50 (m, 2H).
As shown in Figure 23 (b), the carbon spectrum of 4-bromobenzylcyanide prepared by embodiment 23:
13cNMR (126MHz, CDCl
3) δ 133.42,132.66,128.03,118.07,111.26.
Embodiment 24:
In a round-bottomed flask, add 2-benzaldehyde iodine (1.0mmol), acetonitrile (2ml), trimethyl silicon based nitrine (3.0mmol), in the heating module of 80 DEG C, stir 1-2 minute, and then add CuBr
2(2.0mmol), then after the sealing of this system at 80 DEG C reacting by heating 3 hours, be extracted with ethyl acetate after reaction terminates, can obtain product 2-iodobenzene formonitrile HCN by simple column chromatography (eluent uses the mixed solvent of sherwood oil (60 ~ 90 DEG C) and ethyl acetate) after concentrated, yield is 68%.
As shown in Figure 24 (a), the hydrogen spectrum of 2-iodobenzene formonitrile HCN prepared by embodiment 24:
1hNMR (500MHz, CDCl
3) δ 7.95 – 7.92 (m, 1H), 7.62 (dd, J=7.8,1.6Hz, 1H), 7.47 (td, J=7.7,1.1Hz, 1H), 7.30 (td, J=7.9,1.6Hz, 1H).
As shown in Figure 24 (b), the carbon spectrum of 2-iodobenzene formonitrile HCN prepared by embodiment 24:
13cNMR (126MHz, CDCl
3) δ 139.58,134.28,133.70,128.30,120.69,119.33,98.41.
Embodiment 25:
Nitrine trimethyl silicon based in embodiment 1 is replaced by p-toluene sulfonyt azide, and other experiment conditions are constant, and prepare 2-(2-hydroxyethyl) cyanobenzene, yield is 77%.
Embodiment 26
Nitrine trimethyl silicon based in embodiment 1 is replaced by sodiumazide, and other experiment conditions are constant, and prepare 2-(2-hydroxyethyl) cyanobenzene, yield is 73%.
Embodiment 27
Nitrine trimethyl silicon based in embodiment 17 is replaced by trimethyl silicon based diazomethane, and other experiment conditions are constant, prepare 4-methoxy benzonitrile, and yield is 80%.
Embodiment 28
Cupric bromide in embodiment 1 is replaced by a hydration neutralized verdigris, and solvent acetonitrile is replaced by toluene, and the reaction times is 2 hours, and other experiment conditions are constant, and prepare 2-(2-hydroxyethyl) cyanobenzene, yield is 62%.
Embodiment 29
Cupric bromide in embodiment two is replaced by cuprous bromide, and solvent acetonitrile is replaced by methylene dichloride, and the reaction times is 10 hours, and other experiment conditions are constant, and prepare the fluoro-2-of 5-(2-hydroxyethyl) cyanobenzene, yield is 70%.
Embodiment 30
Cupric bromide in embodiment 3 is replaced by cupric chloride, and solvent acetonitrile is replaced by benzene, and temperature becomes 60 DEG C from 80 DEG C, and other experiment conditions are constant, and prepare the fluoro-2-of 6-(2-hydroxyethyl) cyanobenzene, yield is 59%.
Embodiment 31
Cupric bromide in embodiment 3 is replaced by anhydrous cupric sulfate, and solvent acetonitrile is replaced by acetone, and temperature becomes 100 DEG C from 80 DEG C, and other experiment conditions are constant, and prepare the fluoro-2-of 6-(2-hydroxyethyl) cyanobenzene, yield is 73%.
Embodiment 32
Cupric bromide in embodiment 4 is replaced by copper powder, and solvent acetonitrile is replaced by trimethylbenzene, and temperature becomes 120 DEG C from 80 DEG C, and other experiment conditions are constant, and prepare the chloro-2-of 5-(2-hydroxyethyl) cyanobenzene, yield is 67%.
Embodiment 33
Cupric bromide in embodiment 4 is replaced by cuprous bromide, cuprous bromide add-on changes to 1mmol, trimethyl silicon based nitrine add-on changes to 15mmol, solvent acetonitrile is replaced by tetrahydrofuran (THF), reaction times is 12 hours, other experiment conditions are constant, and prepare the chloro-2-of 5-(2-hydroxyethyl) cyanobenzene, yield is 65%
Embodiment 34
Cupric bromide in embodiment 4 is replaced by cupric bromide and cupric chloride, cupric bromide add-on changes to 5mmol, cupric chloride add-on changes to 10mmol, trimethyl silicon based nitrine add-on changes to 15mmol, solvent acetonitrile is replaced by ethyl acetate, other experiment conditions are constant, and prepare the chloro-2-of 5-(2-hydroxyethyl) cyanobenzene, yield is 73%
Embodiment 35
Cupric bromide add-on in embodiment 4 is changed to 1mmol, and trimethyl silicon based nitrine add-on changes to 1.0mmol, and solvent acetonitrile is replaced by ether, and other experiment conditions are constant, and prepare the chloro-2-of 5-(2-hydroxyethyl) cyanobenzene, yield is 58%.
This invention exploits isochroman compounds is starting raw material, with the method providing the azide compounds of nitrogenous source directly to prepare cyanobenzene analog derivative compounds, compare with synthetic method in the past, present invention uses ether compound as synthesis substrate, and reactions steps only has a step, aftertreatment is simple, and reaction conditions is greatly gentle, is the synthetic method of a kind of novelty, simple, efficient synthesis benzonitrile derivative.
Above-described embodiment is not that the present invention is not limited only to above-described embodiment for restriction of the present invention, as long as meet application claims, all belongs to protection scope of the present invention.
Claims (10)
1. one kind is catalyzed and synthesized the novel method of benzonitrile derivative by copper, it is characterized in that the method is take benzyl ethers compounds as substrate, under mantoquita is catalysts conditions, prepare benzonitrile derivative at a certain temperature in conjunction with nitrogenous source, concrete synthetic route is as follows:
Wherein R
1for hydrogen, methyl, halogen F, halogen Cl, halogen Br, the tertiary butyl, methoxyl group or phenyl ring, R
2for methyl or phenyl ring.
2. one kind is catalyzed and synthesized the novel method of benzonitrile derivative by copper, it is characterized in that the method is take compound of benzaldehyde category as substrate, under mantoquita is catalysts conditions, prepare benzonitrile derivative at a certain temperature in conjunction with nitrogenous source, concrete synthetic route is as follows:
R
3for methoxyl group, nitro, phenyl ring, halogen Br or halogen I.
3. a kind of novel method being catalyzed and synthesized benzonitrile derivative by copper as claimed in claim 1 or 2, is characterized in that the mol ratio of mantoquita and nitrogenous source is 1:1 ~ 15; The mol ratio of substrate and nitrogenous source, mantoquita is respectively 1:1 ~ 15 and 1:1 ~ 15.
4. a kind of novel method being catalyzed and synthesized benzonitrile derivative by copper as claimed in claim 1 or 2, it is characterized in that described mantoquita is selected from is one or more mixtures in a hydration neutralized verdigris, cuprous bromide, cupric bromide, cupric chloride, anhydrous cupric sulfate, copper powder.
5. a kind of novel method being catalyzed and synthesized benzonitrile derivative by copper as claimed in claim 1 or 2, is characterized in that described nitrogenous source is the one in p-toluene sulfonyt azide, trimethyl silicon based nitrine, sodiumazide, trimethyl silicon based diazomethane.
6. a kind of novel method being catalyzed and synthesized benzonitrile derivative by copper as claimed in claim 1 or 2, it is characterized in that described temperature of reaction is 60 ~ 120 DEG C, the reaction times is 2 ~ 12 hours.
7. a kind of novel method being catalyzed and synthesized benzonitrile derivative by copper as claimed in claim 6, is characterized in that described temperature of reaction is 80 DEG C.
8. a kind of novel method being catalyzed and synthesized benzonitrile derivative by copper as claimed in claim 1, it is characterized in that the method is added in reaction solvent by benzylic ether to dissolve, add a certain amount of trimethyl silicon based nitrine subsequently, preheating 2 minutes at 80 DEG C, then add a certain amount of copper salt catalyst, finally put into the oil bath pan reacting by heating 2 ~ 12 hours of 80 DEG C; After reaction terminates, system is cooled to room temperature, filters, be then extracted with ethyl acetate, more respectively with water and saturated common salt washing; The organic layer drying obtained, concentrated after by column chromatography, obtain pure compound: 2-(2-hydroxyethyl)-cyanobenzene.
9. a kind of novel method being catalyzed and synthesized benzonitrile derivative by copper as claimed in claim 2, it is characterized in that the method is added in reaction solvent by phenyl aldehyde to dissolve, add a certain amount of trimethyl silicon based nitrine subsequently, preheating 2 minutes at 80 DEG C, then add a certain amount of copper salt catalyst, finally put into the oil bath pan reacting by heating 2 ~ 10 hours of 80 DEG C; After reaction terminates, system is cooled to room temperature, filters, be then extracted with ethyl acetate, more respectively with water and saturated common salt washing; The organic layer drying obtained, concentrated after by column chromatography, obtain pure compound: cyanobenzene.
10. a kind of novel method being catalyzed and synthesized benzonitrile derivative by copper as claimed in claim 8 or 9, is characterized in that described reaction solvent is the one in toluene, methylene dichloride, tetrahydrofuran (THF), ethyl acetate, propyl acetate, acetone, butanone, acetonitrile, ether, benzene, dimethylbenzene, trimethylbenzene, normal hexane.
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| CN113845442A (en) * | 2021-09-30 | 2021-12-28 | 孙国伟 | Method for preparing p-bromobenzonitrile |
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| WO2001017949A1 (en) * | 1999-09-03 | 2001-03-15 | Millennium Specialty Chemicals | Process for the conversion of aldehydes into nitriles using ammonia and hydrogen peroxide |
| WO2008012532A2 (en) * | 2006-07-27 | 2008-01-31 | Astrazeneca Ab | : pyridine-3-carboxamide compounds and their use for inhibiting 11-beta-hydroxysteroid dehydrogenase |
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| US3723463A (en) * | 1970-03-09 | 1973-03-27 | Squibb & Sons Inc | Dibenzooxazepines and dibenzothiazepines |
| WO2001017949A1 (en) * | 1999-09-03 | 2001-03-15 | Millennium Specialty Chemicals | Process for the conversion of aldehydes into nitriles using ammonia and hydrogen peroxide |
| WO2008012532A2 (en) * | 2006-07-27 | 2008-01-31 | Astrazeneca Ab | : pyridine-3-carboxamide compounds and their use for inhibiting 11-beta-hydroxysteroid dehydrogenase |
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| CN108299335A (en) * | 2018-03-01 | 2018-07-20 | 天津力生制药股份有限公司 | A kind of synthetic method converting impurity 3- formoxyl Febustats to Febustat |
| CN113845442A (en) * | 2021-09-30 | 2021-12-28 | 孙国伟 | Method for preparing p-bromobenzonitrile |
| CN113845442B (en) * | 2021-09-30 | 2023-09-29 | 孙国伟 | Method for preparing p-bromobenzonitrile |
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