CN105326799A - Salinomycin granule preparation preparation technology based on improvement of spraying effect - Google Patents
Salinomycin granule preparation preparation technology based on improvement of spraying effect Download PDFInfo
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- CN105326799A CN105326799A CN201510758972.1A CN201510758972A CN105326799A CN 105326799 A CN105326799 A CN 105326799A CN 201510758972 A CN201510758972 A CN 201510758972A CN 105326799 A CN105326799 A CN 105326799A
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Abstract
The invention relates to a salinomycin granule preparation preparation technology based on improvement of the spraying effect. The preparation technology includes the following steps that acidic fermentation liquid is prepared, wherein the pH of salinomycin fermentation liquid is adjusted to 4.0-5.0 through acidic liquid; the acidic fermentation liquid is pre-processed, wherein the temperature of the acidic fermentation liquid with the pH adjusted is preserved for 3-4 h at the temperature of 60-65 DEG C; the pH is adjusted till the salinomycin fermentation liquid is alkaline, a saponification reaction is performed, and salinomycin material liquid is prepared, wherein a certain amount of light calcium carbonate is added into the prepared acidic fermentation liquid so that salinomycin material liquid can be prepared; spraying and drying are performed, wherein after spraying particles are added into the prepared salinomycin material liquid, granules are prepared through a spraying and drying method, and then a salinomycin granule preparation is obtained. The salinomycin granule preparation preparation technology solves the problems that an existing salinomycin granule preparation technology is low yield and not ideal in spraying effect.
Description
Technical field
The present invention relates to medical art, particularly, relating to the salinomycin particle preparation process thereof based on improving spray effect.
Background technology
Salinomycin is the polyethers ionophore type animal specific antibiotic produced by streptomyces albus.Salinomycin particle preparation not only good anti-bacterial effect, low toxicity and low residue, production technology is simple, and raw material is easy to get and cheap, is one of veterinary drug of the most prospect that market is approved.
Salinomycin has stronger inhibitory action and killing action to most of gram positive bacteria and various coccidiosis, not easily produces drug resistance and cross-resistance, and rapidly, residual quantity is extremely low in excretion, can be used for preventing suffering from diarrhoea, promotes production, improves survival rate.Salinomycin has cation transport effect in cell, and especially to the affinity of potassium ion, sodium ion, rubidium ion, but these ion selectivities flow out outside film, cause ionic equilibrium to destroy, osmotic pressure imbalance, cell expansion, be out of shape, break, disintegrate.
Existing salinomycin particle preparation process due to Salinomycin fermentation liquor pretreatment step and spray step the unreasonable yield of salinomycin particle preparation that causes of process lower, and spray effect is undesirable.
Summary of the invention
Technical problem to be solved by this invention is to provide the salinomycin particle preparation process thereof based on improving spray effect, to overcome the problem that yield is low, spray effect is undesirable that existing salinomycin particle preparation process causes.
The present invention's adopted technical scheme that solves the problem is: based on the salinomycin particle preparation process thereof improving spray effect, comprise the following steps:
1) acid fermentation liquid, is prepared: Salinomycin fermentation liquid acid solution is regulated pH to 4.0 ~ 5.0;
2), the pretreatment of acid fermentation liquid: will the acid fermentation liquid of pH be mixed up 60 DEG C ~ 65 DEG C insulations 3 ~ 4 hours;
3), plate-and-frame filtration: to through step 2) add sodium hydroxide as saponifier in the acid fermentation liquid that obtains, add perlite, kieselguhr and precipitated calcium carbonate as filter aid, add alkali liquor and regulate pH to be 8.5 ~ 9.5, abundant saponification;
4) Salinomycin feed liquid, is prepared: make Salinomycin feed liquid to obtaining adding a certain amount of precipitated calcium carbonate in fermentation liquid after step 3) saponification;
5), spraying dry: adopting spray drying method to make granule by adding spray granulation in the Salinomycin feed liquid prepared through step 4), obtaining salinomycin particle preparation; Described spray granulation is made up of following components by weight percent: the calcium carbonate of the Semen Maydis powder of 50 ~ 60 weight portions, the bentonite of 100 ~ 120 weight portions, 80 ~ 100 weight portions; Described spray-dired condition is atomisation pressure: 0.4 ~ 0.45Mpa, and leaving air temp 70 DEG C ~ 80 DEG C, air-introduced machine air quantity is 50 ~ 60HZ.
Existing salinomycin particle preparation process is all generally adopt base extraction for the fermentation process of fermentation liquid, cause the layered velocity of fermentation liquid slow, generally all want about 12h, and layering is not thoroughly and then cause the yield of Salinomycin low, the fermentation technology to Salinomycin of the present invention adopts acid fermentation, after adopt regulate pH alkalize after carry out saponification, improve the speed of fermentation liquid layering, shorten the time of layering, and layering is thorough, improves the yield of Salinomycin; And the present invention is by adding spray granulation and coordinating the spray condition of setting, improves the efficiency of spraying, so, instant invention overcomes the problem that yield is low, spray effect is undesirable that existing salinomycin particle preparation process causes.
Further, the acid solution described in step 1) is sulphuric acid or phosphoric acid.
Further, the medicine valency of the Salinomycin fermentation liquid described in step 1) is 80000 ~ 100000u/ml.
Further, in step 4), the addition of precipitated calcium carbonate is 10% ~ 20% of acid fermentation liquid quality.
Further, step 2) described in alkali liquor be sodium carbonate.
To sum up, the invention has the beneficial effects as follows:
Fermentation technology to Salinomycin of the present invention adopts acid fermentation, after adopt regulate pH alkalize after carry out saponification, improve the speed of fermentation liquid layering, shorten the time of layering, and layering is thorough, improve the yield of Salinomycin, and the present invention is by adding spray granulation and coordinating the spray condition of setting, improves the efficiency of spraying.
Detailed description of the invention
Below in conjunction with embodiment, to the detailed description further of invention do, but embodiments of the present invention are not limited thereto.
Embodiment 1:
Based on the salinomycin particle preparation process thereof improving spray effect, comprise the following steps:
1) acid fermentation liquid, is prepared: the Salinomycin fermentation liquid sulfur acid for adjusting pH to 4.0 by medicine valency being 80000u/ml;
2), the pretreatment of acid fermentation liquid: will the acid fermentation liquid of pH be mixed up 60 DEG C of insulations 3 hours;
3), plate-and-frame filtration: to through step 2) add sodium hydroxide as saponifier in the acid fermentation liquid that obtains, add perlite, kieselguhr and precipitated calcium carbonate as filter aid, add sodium carbonate and regulate pH to be 8.5, abundant saponification;
4), prepare Salinomycin feed liquid: make Salinomycin feed liquid to obtaining adding a certain amount of precipitated calcium carbonate in fermentation liquid after step 3) saponification, described precipitated calcium carbonate addition be 10% of acid fermentation liquid quality;
5), spraying dry: adopting spray drying method to make granule by adding spray granulation in the Salinomycin feed liquid prepared through step 4), obtaining salinomycin particle preparation; Described spray granulation is made up of following components by weight percent: the calcium carbonate of the Semen Maydis powder of 50 weight portions, the bentonite of 100 weight portions, 80 weight portions; Described spray-dired condition is atomisation pressure: 0.4Mpa, leaving air temp 70 DEG C, and air-introduced machine air quantity is 50HZ.
Embodiment 2:
Based on the salinomycin particle preparation process thereof improving spray effect, comprise the following steps:
1) acid fermentation liquid, is prepared: the Salinomycin fermentation liquid sulfur acid for adjusting pH to 4.5 by medicine valency being 90000u/ml;
2), the pretreatment of acid fermentation liquid: will the acid fermentation liquid of pH be mixed up 62 DEG C of insulations 3.5 hours;
3), plate-and-frame filtration: to through step 2) add sodium hydroxide as saponifier in the acid fermentation liquid that obtains, add perlite, kieselguhr and precipitated calcium carbonate as filter aid, add sodium carbonate and regulate pH to be 9.0, abundant saponification;
4), prepare Salinomycin feed liquid: make Salinomycin feed liquid to obtaining adding a certain amount of precipitated calcium carbonate in fermentation liquid after step 3) saponification, described precipitated calcium carbonate addition be 15% of acid fermentation liquid quality;
5), spraying dry: adopting spray drying method to make granule by adding spray granulation in the Salinomycin feed liquid prepared through step 4), obtaining salinomycin particle preparation; Described spray granulation is made up of following components by weight percent: the calcium carbonate of the Semen Maydis powder of 60 weight portions, the bentonite of 120 weight portions, 100 weight portions; Described spray-dired condition is atomisation pressure: 0.45Mpa, leaving air temp 80 DEG C, and air-introduced machine air quantity is 60HZ.
Embodiment 3:
Based on the salinomycin particle preparation process thereof improving spray effect, comprise the following steps:
1) acid fermentation liquid, is prepared: the Salinomycin fermentation liquid sulfur acid for adjusting pH to 5.0 by medicine valency being 100000u/ml;
2), the pretreatment of acid fermentation liquid: will the acid fermentation liquid of pH be mixed up 65 DEG C of insulations 4 hours;
3), plate-and-frame filtration: to through step 2) add sodium hydroxide as saponifier in the acid fermentation liquid that obtains, add perlite, kieselguhr and precipitated calcium carbonate as filter aid, add sodium carbonate and regulate pH to be 9.5, abundant saponification;
4), prepare Salinomycin feed liquid: make Salinomycin feed liquid to obtaining adding a certain amount of precipitated calcium carbonate in fermentation liquid after step 3) saponification, described precipitated calcium carbonate addition be 20% of acid fermentation liquid quality;
5), spraying dry: adopting spray drying method to make granule by adding spray granulation in the Salinomycin feed liquid prepared through step 4), obtaining salinomycin particle preparation; Described spray granulation is made up of following components by weight percent: the calcium carbonate of the Semen Maydis powder of 55 weight portions, the bentonite of 110 weight portions, 90 weight portions; Described spray-dired condition is atomisation pressure: 0.42Mpa, leaving air temp 75 DEG C, and air-introduced machine air quantity is 55HZ.
As mentioned above, the present invention can be realized preferably.
Claims (5)
1., based on the salinomycin particle preparation process thereof improving spray effect, it is characterized in that, comprise the following steps:
1) acid fermentation liquid, is prepared: Salinomycin fermentation liquid acid solution is regulated pH to 4.0 ~ 5.0;
2), the pretreatment of acid fermentation liquid: will the acid fermentation liquid of pH be mixed up 60 DEG C ~ 65 DEG C insulations 3 ~ 4 hours;
3), plate-and-frame filtration: to through step 2) add sodium hydroxide as saponifier in the acid fermentation liquid that obtains, add perlite, kieselguhr and precipitated calcium carbonate as filter aid, add alkali liquor and regulate pH to be 8.5 ~ 9.5, abundant saponification;
4) Salinomycin feed liquid, is prepared: make Salinomycin feed liquid to obtaining adding a certain amount of precipitated calcium carbonate in fermentation liquid after step 3) saponification;
5), spraying dry: adopting spray drying method to make granule by adding spray granulation in the Salinomycin feed liquid prepared through step 4), obtaining salinomycin particle preparation; Described spray granulation is made up of following components by weight percent: the calcium carbonate of the Semen Maydis powder of 50 ~ 60 weight portions, the bentonite of 100 ~ 120 weight portions, 80 ~ 100 weight portions; Described spray-dired condition is atomisation pressure: 0.4 ~ 0.45Mpa, and leaving air temp 70 DEG C ~ 80 DEG C, air-introduced machine air quantity is 50 ~ 60HZ.
2. the salinomycin particle preparation process thereof based on improving spray effect according to claim 1, it is characterized in that, the acid solution described in step 1) is sulphuric acid or phosphoric acid.
3. the salinomycin particle preparation process thereof based on improving spray effect according to claim 1, it is characterized in that, the medicine valency of the Salinomycin fermentation liquid described in step 1) is 80000 ~ 100000u/ml.
4. the salinomycin particle preparation process thereof based on improving spray effect according to claim 1, it is characterized in that, in step 4), the addition of precipitated calcium carbonate is 10% ~ 20% of acid fermentation liquid quality.
5. according to claim 1 based on improving the salinomycin particle preparation process thereof of spray effect, to it is characterized in that, step 2) described in alkali liquor be sodium carbonate.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510758972.1A CN105326799A (en) | 2015-11-10 | 2015-11-10 | Salinomycin granule preparation preparation technology based on improvement of spraying effect |
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| CN201510758972.1A CN105326799A (en) | 2015-11-10 | 2015-11-10 | Salinomycin granule preparation preparation technology based on improvement of spraying effect |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108342426A (en) * | 2018-03-30 | 2018-07-31 | 内蒙古拜克生物有限公司 | A kind of method of fermenting and producing salinomycin |
| CN108440558A (en) * | 2018-03-30 | 2018-08-24 | 内蒙古拜克生物有限公司 | A kind of method of purification of Salinomycin Sodium |
-
2015
- 2015-11-10 CN CN201510758972.1A patent/CN105326799A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108342426A (en) * | 2018-03-30 | 2018-07-31 | 内蒙古拜克生物有限公司 | A kind of method of fermenting and producing salinomycin |
| CN108440558A (en) * | 2018-03-30 | 2018-08-24 | 内蒙古拜克生物有限公司 | A kind of method of purification of Salinomycin Sodium |
| CN108440558B (en) * | 2018-03-30 | 2019-04-09 | 内蒙古拜克生物有限公司 | A kind of method of purification of Salinomycin Sodium |
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Application publication date: 20160217 |