CN105326791A - Emulsus O/W-type emulsified combination containing alkyl phosphate and preparation method of emulsus O/W-type emulsified combination - Google Patents

Abstract

The invention discloses an emulsus O/W-type emulsified combination containing alkyl phosphate and a preparation method of the emulsus O/W-type emulsified combination. The emulsified combination comprises, by weight, higher than 0.2% of alkyl phosphate (A), 0.5-6% of polyglycerol fatty acid ester (B), 0.1-1% of methyl acrylate and alkyl acrylate ester copolymer (C), 0.6-8% of amphiphilic lipid (D), 1-15% of polyhydric alcohol (E) and 0.5-4% of self-emulsifying glycerin fatty acid ester (F), and viscosity of the emulsified combination at 20 DEG C is 6000-50000cps.. The emulsus O/W-type emulsified combination is excellent in long-time emulsifying stability.

Description

A kind of creaminess O/W type emulsification composition and manufacture method thereof containing alkyl phosphate

Technical field

The present invention relates to creaminess O/W type emulsification composition, particularly relate to a kind of the creaminess O/W type emulsification composition and the manufacture method thereof that contain alkyl phosphate.

Background technology

In order to prepare the preparation compositions that effectively can play alkyl phosphate function, need to coordinate alkyl phosphate with ratio more than certain concentration in the composition.But, as electrolytical alkyl phosphate, there is the so-called distinctive character of electrolyte reducing oil-water interfaces film strength in emulsification composition.Therefore, when manufacturing emulsification composition (particularly the O/W type emulsification composition) containing alkyl phosphate, the known emulsified particles that causes is coalescent, and easy generation aqueous phase is separated and produces oil slick (oilemergence) etc. with oil phase.In addition, even if unchanged in appearance, but due to the impact of alkyl phosphate, As time goes on emulsification system itself worsens sometimes, and viscosity is sharply declined.

Therefore; in order to realize excellent emulsion stability under long-term storage conditions; when preparing the O/W type emulsification composition containing alkyl phosphate, such as, coordinate polyglyceryl fatty acid ester, acrylic arid methacrylic acid alkyl ester copolymer, alkanoyl lactic acid (alkanoyllacticacid) or its salt etc.As the mechanism of the decentralized stabilization of its compositions, be utilize the electric repulsion effect produced by the ionic emulsifying agent of alkanoyl lactic acid and so on.

Usually, compositions containing ionic emulsifying agent, although demonstrate stability in the O/W type emulsification composition that the liquid fluidities such as emulsion are high, but in tool sticking creaminess O/W type emulsification composition, the stabilisation of system can not be met by the compositions be used alone containing ionic emulsifying agent.Therefore, the O/W type emulsification system using ionic emulsifying agent to be simultaneously combined with the solid such as higher fatty acids or higher alcohol amphipathic lipids is obtained.But, during containing electrolyte, because electrolyte causes system unstable in above-mentioned combination, therefore damaged the stability of compositions, viscosity can not have been kept for a long time.Particularly containing in electrolytical compositions, because variations in temperature facilitates the separation etc. of compositions, be therefore difficult to obtain being combined with the stable composition electrolytical, there is high viscosity.

Summary of the invention

Main purpose of the present invention is to provide a kind of creaminess O/W type emulsification composition containing alkyl phosphate, even if described emulsification composition also shows excellent emulsion stability under the high temperature conditions or under the violent preservation condition of variations in temperature.

The present inventor conducts in-depth research to solve above-mentioned problem, found that by coordinating self-emulsifying type fatty acid glyceride further in the emulsification composition containing alkyl phosphate, polyglyceryl fatty acid ester, acrylic arid methacrylic acid alkyl ester copolymer, amphipathic lipids and polyhydric alcohol, emulsifying capacity significantly improves, although its result can be prepared containing electrolyte, the compositions of high viscosity and emulsion stability also can be maintained.In addition, the present inventor confirms described emulsification composition and has high-grade outward appearance, improves the sensation of thickness, lubricate for during skin as sense of touch, uses rear sensation excellent.The present invention repeatedly studies further based on above-mentioned discovery and completes.

The invention provides a kind of following creaminess O/W type emulsification composition and manufacture method thereof, and the stable emulsifying method of creaminess O/W type emulsification composition containing alkyl phosphate.

1st: a kind of creaminess O/W type emulsification composition, in the total amount of described emulsification composition, contain (A) ~ (F) composition in following ratio, the viscosity of described emulsification composition at 20 DEG C is 6000 ~ 50000cps:

(A) alkyl phosphate more than 0.2 % by weight, described alkyl phosphate is selected from carbon number 1 ~ 36, preferred carbon number 3 ~ 32, more preferably carbon number 6 ~ 24, the particularly preferably alkyl phosphate of carbon number 8 ~ 18, most preferably heptan alkyl phosphate, Monododecylphosphate, two 1-isobutyl-3,5-dimethylhexylphosphoric acid, single myristyl phosphate ester, two myristyl phosphate ester, single hexadecanyl phosphate, double hexadecyl acid ester, single octadecyl phosphate ester, two octadecyl phosphate ester, and at least one in their salt;

(B) polyglyceryl fatty acid ester 0.6 ~ 5 % by weight;

(C) acrylic arid methacrylic acid alkyl ester copolymer 0.1 ~ 1 % by weight;

(D) amphipathic lipids 0.6 ~ 8 % by weight;

(E) polyhydric alcohol 1 ~ 15 % by weight; And

(F) self-emulsifying type fatty acid glyceride 0.5 ~ 4 % by weight.

2nd: the creaminess O/W type emulsification composition according to the 1st, described (B) composition is the ester that carbon number 12 ~ 36, the preferably fatty acid of carbon number 18 ~ 32, more preferably carbon number 24 ~ 28 and the polyglycereol of the degree of polymerization more than 6 are formed.

3rd: the creaminess O/W type emulsification composition according to the 1st or 2, described (C) composition has the alkyl of carbon number 5 ~ 40, preferably carbon number 8 ~ 36, more preferably carbon number 16 ~ 24.

4th: the creaminess O/W type emulsification composition according to any one of 1st ~ 3, described (D) composition contains at least one be selected from higher fatty acids, higher alcohol, mono alkyl glyceryl ether, ceramide, glycosyl ceramide, glycolipid, lecithin, lecithin derivative and their analog.

5th: the creaminess O/W type emulsification composition according to any one of 1st ~ 4, described (E) composition be 2 yuan or the polyhydric alcohol of 3 yuan.

6th: the creaminess O/W type emulsification composition according to any one of 1st ~ 5, described (F) composition is for mixing hydrophilic surfactant active thus improve hydrophilic self-emulsifying type fatty acid glyceride.

7th: the creaminess O/W type emulsification composition according to any one of 1st ~ 6, further containing (G) moisture 30 ~ 80 % by weight, preferably 40 ~ 70 % by weight, more preferably 45 ~ 65 % by weight.

8th: the creaminess O/W type emulsification composition according to the 7th, described moisture is one or more in distilled water, ion exchange water, aquesterilisa and pure water.

9th: the creaminess O/W type emulsification composition according to any one of 1st ~ 8, further containing (H) oil content 1 ~ 40 % by weight, preferably 2 ~ 35 % by weight, more preferably 5 ~ 30 % by weight.

10th: the creaminess O/W type emulsification composition according to the 9th, described oil content is one or more in vegetable oil, animal oil, hydro carbons fluid oil, high-grade aliphatic ester, wax class, glyceride oils, chain polysiloxanes, cyclic polysiloxanes and cross-linking type polysiloxanes.

11st: the creaminess O/W type emulsification composition according to any one of 1st ~ 10, described compositions is cosmetics for skin or external preparation for skin medicine or accurate pharmaceuticals.

12nd: the application of creaminess O/W type emulsification composition in the manufacture of the accurate pharmaceuticals of cosmetics for skin, dermal drug or external preparation for skin according to any one of 1st ~ 10.

13rd: a kind of preparation method of creaminess O/W type emulsification composition, comprises the steps (1) ~ (3), contain following compositions in described emulsification composition relative to total composition in following ratio:

(A) alkyl phosphate more than 0.2 % by weight, (B) polyglyceryl fatty acid ester 0.6 ~ 5 % by weight, (C) acrylic arid methacrylic acid alkyl ester copolymer 0.1 ~ 1 % by weight, (D) amphipathic lipids 0.6 ~ 8 % by weight, (E) polyhydric alcohol 1 ~ 15 % by weight and (F) self-emulsifying type fatty acid glyceride 0.5 ~ 4 % by weight, the viscosity of described emulsification composition at 20 DEG C is 6000 ~ 50000cps

(1) use the compositions containing (B) polyglyceryl fatty acid ester, (D) amphipathic lipids, (E) polyhydric alcohol and (F) self-emulsifying type fatty acid glyceride, prepare the step of non-water and milk compound;

(2) preparation contains the step of the aqueous solution of (A) alkyl phosphate and (C) acrylic arid methacrylic acid alkyl ester copolymer, described alkyl phosphate is selected from carbon number 1 ~ 36, preferred carbon number 3 ~ 32, more preferably carbon number 6 ~ 24, the particularly preferably alkyl phosphate of carbon number 8 ~ 18, most preferably heptan alkyl phosphate, Monododecylphosphate, two 1-isobutyl-3,5-dimethylhexylphosphoric acid, single myristyl phosphate ester, two myristyl phosphate ester, single hexadecanyl phosphate, double hexadecyl acid ester, single octadecyl phosphate ester, two octadecyl phosphate ester, and at least one in their salt, and

(3) described non-water and milk compound is heated with aqueous solution the step mixing and carry out emulsifying.

14th: a kind of stable emulsifying method of the creaminess O/W type emulsification composition containing alkyl phosphate, comprise the steps (1) ~ (3), in described emulsification composition, contain following compositions relative to total composition in following ratio:

(A) alkyl phosphate more than 0.2 % by weight, (B) polyglyceryl fatty acid ester 0.6 ~ 5 % by weight, (C) acrylic arid methacrylic acid alkyl ester copolymer 0.1 ~ 1 % by weight, (D) amphipathic lipids 0.6 ~ 8 % by weight, (E) polyhydric alcohol 1 ~ 15 % by weight and (F) self-emulsifying type fatty acid glyceride 0.5 ~ 4 % by weight, the viscosity of described emulsification composition at 20 DEG C is 6000 ~ 50000cps

(1) compositions containing (B) polyglyceryl fatty acid ester, (D) amphipathic lipids, (E) polyhydric alcohol and (F) self-emulsifying type fatty acid glyceride is used to prepare the step of non-water and milk compound,

(2) preparation contains the step of the aqueous solution of (A) alkyl phosphate and (C) acrylic arid methacrylic acid alkyl ester copolymer, described alkyl phosphate is selected from carbon number 1 ~ 36, preferred carbon number 3 ~ 32, more preferably carbon number 6 ~ 24, the particularly preferably alkyl phosphate of carbon number 8 ~ 18, most preferably heptan alkyl phosphate, Monododecylphosphate, two 1-isobutyl-3,5-dimethylhexylphosphoric acid, single myristyl phosphate ester, two myristyl phosphate ester, single hexadecanyl phosphate, double hexadecyl acid ester, single octadecyl phosphate ester, two octadecyl phosphate ester, and at least one in their salt, and

(3) described non-water and milk compound is heated with aqueous solution the step mixing and carry out emulsifying.

According to the present invention, although a kind of alkyl phosphate containing being usually difficult to emulsifying can be provided, but also inhibits under high temperature or the violent condition of variations in temperature separations, oil slick, gel formation etc., the creaminess O/W type emulsification composition of emulsion stability excellence for a long time.

Due to alkyl phosphate can be coordinated in a large number with stable state, so creaminess O/W type emulsification composition of the present invention is useful as the cosmetics or skin preparations for extenal use (medicine or accurate pharmaceuticals) etc. taking alkyl phosphate as effective ingredient.Particularly containing alkyl phosphate or the O/W type emulsification composition of its salt etc. in heptan, effectively can play the metabolism facilitation of moisture-keeping function that this material has or skin, prevention microgroove, give skin elasticity etc., as to prevent skin aging beautify the effective cosmetics of skin or skin preparations for extenal use useful.

In addition, a kind of creaminess O/W type emulsification composition can be provided according to the present invention, described creaminess O/W type emulsification composition not only long-term emulsion stability is excellent, and by suitably adjusting the kind of each composition such as alkyl phosphate, polyglyceryl fatty acid ester, amphipathic lipids, acrylic arid methacrylic acid alkyl ester copolymer, polyhydric alcohol, self-emulsifying type fatty acid glyceride coordinated and mixing ratio, high-grade outward appearance can be had, suppress the sensation of oily taste and thickness significantly, skin lubricity is good, and skin use sense is excellent.

As mentioned above, creaminess O/W type emulsification composition of the present invention, particularly as the medicine of external preparation such as cosmetics for skin (comprising scalp to apply some make up), external preparation for skin (comprising scalp) or accurate pharmaceuticals useful.

And then, the present invention is directed to the creaminess O/W type emulsification composition more in large quantities containing alkyl phosphate, provide a kind of method improving emulsion stability.Therefore, the creaminess O/W type emulsification composition containing alkyl phosphate can be obtained easily according to method of the present invention, described creaminess O/W type emulsification composition can play the effect of the alkyl phosphate with various physiological function effectively, effectively utilizes alkyl phosphate.

Detailed description of the invention

Below in conjunction with embodiment, embodiment of the present invention are described in detail.It will be understood to those of skill in the art that following examples are only the preferred embodiments of the present invention, so that understand the present invention better, thus should not be considered as limiting scope of the present invention.For a person skilled in the art, the present invention can have various modifications and variations, within the spirit and principles in the present invention all, and any amendment done, equivalent replacement or improvement etc., all should be included within protection scope of the present invention.Experimental technique in following embodiment, if no special instructions, is conventional method; Experiment material used, if no special instructions, is and is purchased available from routine biochemistry chemical reagent work.Quantitative experiment in following embodiment, all arranges and repeats experiment for three times, results averaged.

1, creaminess O/W type emulsification composition

Creaminess O/W type emulsification composition of the present invention, following (A) ~ (F) composition containing ormal weight.Below, formation of the present invention is described in detail in detail.

(A) composition: alkyl phosphate

There is no particular limitation for the alkyl phosphate used in the present invention, preferably be applicable to skin, play the alkyl phosphate of physiological function, such as, can enumerate the alkyl phosphate in the medicine that can be engaged in external preparation, particularly cosmetics or external or accurate pharmaceuticals widely.Preferred water dissolubility or hydrophilic.

As described alkyl phosphate, carbon number 1 ~ 36 can be enumerated particularly, preferred carbon number 3 ~ 32, more preferably carbon number 6 ~ 24, the particularly preferably alkyl phosphate of carbon number 8 ~ 18, most preferably heptan alkyl phosphate, Monododecylphosphate, two 1-isobutyl-3,5-dimethylhexylphosphoric acid, single myristyl phosphate ester, two myristyl phosphate ester, single hexadecanyl phosphate, double hexadecyl acid ester, single octadecyl phosphate ester, two octadecyl phosphate ester, and their salt.Above-mentioned substance can be used alone a kind, or combination in any two or more use.

It should be noted that, as above-mentioned various salt, can enumerate: acid-addition salts (inorganic acid salt that such as hydrochlorate, hydrobromate, hydriodate, sulfate, phosphate, nitrate are such, the acylate etc. that such as acetate, lactate, tartrate, benzoate, citrate, mesylate, esilate, benzene sulfonate, toluene fulfonate, tosilate (tosilate), isethionate, glucuronate, gluconate are such); The salt of acid natural amino acid (such as, aspartic acid, glutamic acid etc.); The salt of alkali metal (such as, potassium, sodium etc.); The salt of alkaline-earth metal (such as, calcium, magnesium etc.); Ammonium salt; Tetramethyl ammonium; 4-butyl ammonium; Pharmaceutically acceptable organic amine (such as, alkylamine (such as, methyl amine, dimethyl amine, Trimethylamine, triethylamine etc.), heterocyclic amine (such as, pyridine, picoline, piperidines etc.), alkanolamine (such as, ethanolamine, diethanolamine, triethanolamine etc.), dicyclohexylamine, N, N'-dibenzyl-ethylenediamin, cyclopenta amine, benzyl amine, dibenzyl amine, phenethyl amine, three (hydroxymethyl) methyl amine, N-methyl-D-glucosamine etc.) salt; The salt etc. of Basic natural amino acids (such as, arginine, lysine, ornithine, histidine etc.).Wherein, the salt formed with alkali metal can preferably be enumerated.

There is no particular limitation for the ratio of the alkyl phosphate coordinated in emulsification composition of the present invention, as long as play the amount of expected effect for its alkyl phosphate.Specifically, different according to the kind of alkyl phosphate used, can enumerate in every 100 % by weight final emulsification compositions, aforementioned proportion is at least more than 0.2 % by weight, preferably 0.5 ~ 8 % by weight, be more preferably 1 ~ 6 % by weight scope.

(B) composition: polyglyceryl fatty acid ester

As the polyglyceryl fatty acid ester used in the present invention, there is no particular limitation, can enumerate that carbon number is 12 ~ 36, preferably the fatty acid of carbon number 18 ~ 32, more preferably carbon number 24 ~ 28 and the degree of polymerization are the ester that formed of polyglycereol of more than 6, particularly 6 ~ 10.The fatty acid forming ester with polyglycereol can be any one fatty acid in saturated, unsaturated, straight-chain or branched, specifically can enumerate capric acid, lauric acid, different tridecanoic acid, myristic acid, Palmic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, behenic acid or castor oil acid etc.

As polyglyceryl fatty acid ester, six polyglycereol monolaurates specifically can be enumerated, six polyglycereol list isostearates, six polyglycereol list myristinates, six Plurol Oleique CC497s, six polyglycereol two myristinates, six polyglycereol dipalmitates, six polyglycerol distearates, six polyglycereol two behenates, six polyglycereol trilaurins, six polyglycereol three myristinates, six polyglycereol tripalmitates, six polyglycereol tristearates, six polyglycereol three behenates, six polyglycereol four laurates, six polyglycereol four myristinates, six polyglycereol four cetylates, six polyglycereol tetrastearates, six polyglycereol four behenates, six polyglycereol five laurates, six polyglycereol five myristinates, six polyglycereol five cetylates, six polyglycereol five stearates, six polyglycereol five behenates, ten polyglycereol monkey cells, ten polyglycereol monolaurates, ten polyglycereol list myristinates, ten polyglycereol monopalmitates, ten polyglycereol monostearates, ten polyglycerol monooleate, ten polyglycereol list linoleates, ten polyglycereol list isostearates, ten polyglycereol dicaprates, ten polyglycereol dilaurates, ten polyglycereol two myristinates, ten polyglycereol dipalmitates, ten polyglycerol distearates, ten Risorex PGIS 22s, ten polyglycereol trilaurins, ten polyglycereol three myristinates, ten polyglycereol tripalmitates, ten polyglycereol tristearates, ten polyglycereol trioleates, ten polyglycereol three behenates, ten polyglycereol five stearates, ten polyglycereol five oleates, ten polyglycereol five isostearates, ten polyglycereol seven stearates, ten polyglycereol ten stearates, ten polyglycereol ten oleates, ten polyglycereol ten isostearates etc., but be not limited to these.

Described polyglyceryl fatty acid ester can be used alone one, or also can combination in any is two or more uses.And then, as polyglyceryl fatty acid ester, can preferably use HLB to be the polyglyceryl fatty acid ester of the scope of more than 10, particularly 10 ~ 15.Relative to every 100 % by weight final emulsification compositions, preferably contain described polyglyceryl fatty acid ester use with the ratio of 0.6 ~ 5 % by weight, the more preferably ratio of 1 ~ 4 % by weight.

(C) composition: acrylic arid methacrylic acid alkyl ester copolymer

As the acrylic arid methacrylic acid alkylester polymers used in the present invention, have no particular limits, the carbon number usually can enumerating alkyl chain be 5 ~ 40, preferably carbon number 8 ~ 36, more preferably carbon number 16 ~ 24.Described material can utilize can easily by product that business obtains, have no particular limits, specifically, Carbopol (trade mark) 1342 (Lubrizol Inc.), Carbopol (trade mark) ETD2020 (Lubrizol Inc.), Pemulen (trade mark) TR-1 (Lubrizol Inc.), PemulenTR-2 (Lubrizol Inc.) etc. can be enumerated.

Described acrylic arid methacrylic acid alkylester polymers can be used alone one, or also can combination in any is two or more uses.Relative to every 100 % by weight final emulsification compositions, preferably contain described acrylic arid methacrylic acid alkylester polymers use with the ratio of 0.1 ~ 1 % by weight, the more preferably ratio of 0.1 ~ 0.6 % by weight.

(D) composition: amphipathic lipids

Amphipathic lipids in 1 molecule, has " hydrophilic group " (hydrophilic functional group) and " lipophilic group " (hydrophobic functional groups) concurrently, do not dissolve in water but has the general name of the solid lipid of the tendency of dispersion.

As (D) composition, if the composition allowed in pharmacy or fragrant adornment, there is no particular limitation, specifically, can enumerate higher fatty acids, higher alcohol, mono alkyl glyceryl ether, sphingolipid, glycolipid, lecithin, lecithin derivative and their analog etc.Such as, the higher fatty acids (carbon number 14 ~ 22) such as myristic acid, stearic acid, oleic acid, Palmic acid, behenic acid can be enumerated; As higher alcohol, the saturated or undersaturated alcohol (carbon number 8 ~ 22) of the straight or brancheds such as capryl alcohol, myristyl alcohol, spermol, cetearyl alcohol, stearyl alcohol, behenyl alcohol, isooctadecanol, cholesterol, plant sterol; The mono alkyl glyceryl ether (atomic number of alkyl carbon 8 ~ 22) such as .alpha.-hexadecylglyceryl ether, batilol (single monostearoyl glyceride ether), selachyl alcohol, Glycerol monoisooctadecyl ether, Dan Ershi bis-glycerin ether; Sphingolipid and their glucosides (such as glycosyl ceramide etc.) such as ceramide, plant sheath amine alcohol; The glycolipid matter such as galactose lipid, sulfo group lipid, glycosyl sphingolipid matter; The lecithin such as soybean lecithin, Ovum Gallus domesticus Flavus lecithin, LYSOLECITHIN SUNLECITHIN A; The lecithin derivative such as hydrogenated soya phosphatide, partially hydrogenated soybean phospholipid, hydrogenation egg yolk lecithin, partial hydrogenation egg yolk lecithin, hydroxylating soybean phospholipid, hydrogenated soybean lysophosphatide (so-called derivant herein refers to and the unsaturated bond of the middle alkyl such as lecithin is carried out hydrogenation or hydroxylating); Phospholipid in the lecithin such as phosphatidylcholine, PHOSPHATIDYL ETHANOLAMINE, phosphatidylinositols, sphingomyelins heats up in a steamer compound.

Wherein, preferably use the amphipathic lipids be selected from higher fatty acids, higher alcohol, mono alkyl glyceryl ether, lecithin, lecithin derivative as (D) composition.By the amphipathic lipids described in choice for use, following O/W type emulsification composition can be obtained, the emulsion stability of described O/W type emulsification composition improves further, even if the problem such as gelation, oil slick also significantly reduces under high temperature or the violent preservation condition of variations in temperature.

Amphipathic lipids can be used alone or combines material of more than two kinds and uses.The mixing ratio of amphipathic lipids is different according to dosage form etc., can enumerate in final emulsification composition 100 % by weight, be preferably 0.6 ~ 8 % by weight, be more preferably the scope of 1 ~ 5 % by weight, more preferably 1 ~ 3 % by weight.Particularly, during by soybean lecithin and batilol combination, the emulsion stability more excellent than the situation of other combinations can be demonstrated.

(E) composition: polyhydric alcohol

Emulsification composition of the present invention, by coordinating polyhydric alcohol, can improve the expression of the emulsifying capacity of polyglyceryl fatty acid ester etc. further.

There is no particular limitation for polyhydric alcohol used herein, specifically, can enumerate the polyhydric alcohol of ethylene glycol, diethylene glycol, Polyethylene Glycol, 1,3 butylene glycol, propylene glycol, dipropylene glycol, isoprene, pentanediol etc. 2 yuan; The polyhydric alcohol of glycerol (comprising concentrated glycerin) etc. 3 yuan and the polyglycereol (such as two glycerol, triglycerin, four glycerol etc.) of the degree of polymerization 2 ~ 10; The sugar alcohols such as sorbitol, maltose alcohol, fructose.Preferably glycerine.

Described polyhydric alcohol can be used alone one, or combination in any is two or more uses.Now, coordinate polyhydric alcohol to make the ratio in 1 ~ 15 % by weight in final emulsification composition 100 % by weight contain polyhydric alcohol, preferably contain polyhydric alcohol in the ratio of 1 ~ 12 % by weight.

(F) composition: self-emulsifying type fatty acid glyceride

Emulsification composition of the present invention, by coordinating self-emulsifying type fatty acid glyceride, giving the emulsifying of O/W type with electrolyte-resistant, can seek the stabilisation of emulsification system.Self-emulsifying type fatty acid glyceride for the hydrophilic surfactant active such as fatty acid soaps or cithrol is mixed with fatty acid glyceride, the lipophilic emulsifier with non-ionic surfactant effect that fatty acid glyceride is disperseed in water.In self-emulsifying type fatty acid glyceride used herein, fatty acid glyceride is expected to be made up of single glycerol, specifically, and preferred self-emulsifying type monomyristin, self-emulsifying type glyceryl monostearate, self-emulsifying type glycerin mono-fatty acid ester etc.And then expect preferably to use self-emulsifying type glyceryl monostearate.

As (F) composition in the present invention, the self-emulsifying type fatty acid glyceride obtained by business can be used, such as, can enumerate LeodolMS165V (Kao Corp's system); NIKKOLMGS-150V (Nikko Chemicals Co., Ltd's system), NIKKOLMGS-ASEV (Nikko Chemicals Co., Ltd's system) etc.

It should be noted that, described self-emulsifying type fatty acid glyceride can be used alone one, or also can combination in any is two or more uses.Now, coordinate self-emulsifying type fatty acid glyceride, make to contain self-emulsifying type fatty acid glyceride with the ratio of the ratio of 0.5 ~ 4 % by weight, preferably 0.5 ~ 3 % by weight in final emulsification composition 100 % by weight.

And then, in O/W type emulsification composition of the present invention, except above-mentioned (A) ~ (F) composition, following (G) composition respectively containing ormal weight: moisture and (H) composition: oil content.

(G) composition: moisture

O/W type emulsification composition of the present invention contains moisture, as moisture except distilled water, ion exchange water, aquesterilisa, pure water, also can use the water containing alkyl phosphate.As the described water containing alkyl phosphate, such as, can enumerate sea water, thermal water, mineral water etc.It should be noted that, so-called sea water is any one in superficial water, mid-water, deep water, super deep water herein.

Described in final emulsification composition 100 % by weight, the mixing ratio of moisture has no particular limits, and usually suitably can select from the scope of 30 ~ 80 % by weight, preferably 40 ~ 70 % by weight, more preferably 45 ~ 65 % by weight.

(H) composition: oil content

There is no particular limitation for the oil content used in the present invention.Specifically, the oils such as Oleum Arachidis hypogaeae semen, Oleum sesami, soybean oil, safflower oil, American Avocado Tree oil, Oleum Helianthi, Semen Maydis oil, Oleum Brassicae campestris, Oleum Gossypii semen, Oleum Ricini, Camellia oil, Oleum Cocois, olive oil, poppy seed oil, cupu oil and jojoba wet goods vegetable oil and Adeps Bovis seu Bubali, Adeps Sus domestica and Pilus Caprae seu Ovis wet goods animal oil can be enumerated; The hydro carbons fluid oils such as vaseline, liquid paraffin, squalane, vegetalitas squalane and alpha-olefin low polymers; Isopropyl myristate, IPIS, myristyl myristate, cetin, isooctyl acid cetyl, the different cetyl of myristic acid, n-butyl myristate, myristic acid octyl group lauryl, linolenic acid isopropyl ester, castor oil acid propyl ester, castor oil acid isopropyl ester, isobutyl ricinoleate, castor oil acid heptyl ester, ethyl sebacate and the contour level fatty acid ester of diisopropyl adipate; The wax classes such as cera alba, spermaceti and haze tallow; The wax such as microwax, paraffin class; Saturated or the unsaturated fatty acid of aceto-glyceride, three isooctyl acid glyceride, three glyceryl isostearates, three different tripalmitins, three-2 ethyl hexanoic acid glyceride, glyceryl monostearate, two Glyceryl Behenates, myristin, three (caprylic capric) glyceride, carbon number 12 ~ 18 single, two, the glyceride oils such as triglycerin mixture; The chain polysiloxanes such as methyl polysiloxane, dimethyl polysiloxane, methyl phenyl silicone, methylhydrogenpolysi,oxane (methylhydrogenpolysiloxane), the cyclic polysiloxanes such as decamethylcyclopentasiloxane, prestox ring fourth siloxanes, methyl cyclosiloxane, the cross-linking type polysiloxanes such as cross-linking type methyl polysiloxane and cross-linking type methyl phenyl silicone, such as, with silicone oil etc. such as the modified polyorganosiloxanes of the modification such as polyoxyethylene or polyoxypropylene.

Described oil content can be used alone one, or also can combination in any is two or more uses.Can enumerate relative to every 100 % by weight final emulsification compositions, preferably contain described oil content carry out using described oil content with the ratio of 1 ~ 40 % by weight, preferably 2 ~ 35 % by weight, more preferably 5 ~ 30 % by weight.

Emulsification composition of the present invention, suitably can be selected the compound recorded to be prepared from as above-mentioned (A) ~ (H) composition, preferably be enumerated the combination of the following stated.

Combination (i)

(A) composition alkyl phosphate in heptan; (B) composition six polyglycereol monolaurate; (C) composition acrylic arid methacrylic acid alkyl ester copolymer; (D) composition spermol, cetearyl alcohol, stearyl alcohol; (E) composition concentrated glycerin, dipropylene glycol; (F) composition self-emulsifying type glyceryl monostearate; (G) composition pure water; (H) composition three (caprylic capric) glyceride, methyl polysiloxane.

Combination (ii)

(A) composition Monododecylphosphate; (B) composition ten polyglycereol list myristinate; (C) composition acrylic arid methacrylic acid alkyl ester copolymer; (D) composition behenyl alcohol, isooctadecanol; (E) composition concentrated glycerin, dipropylene glycol; (F) composition self-emulsifying type glyceryl monooleate; (G) composition pure water; (H) component liquids paraffin, three (caprylic capric) glyceride, methyl polysiloxane.

Combination (iii)

(A) composition Monododecylphosphate; (B) composition six polyglycereol two behenate, ten polyglycereol monostearates; (C) composition acrylic arid methacrylic acid alkyl ester copolymer; (D) composition Palmic acid, behenic acid; (E) composition concentrated glycerin; (F) composition self-emulsifying type glyceryl monostearate; (G) composition pure water; (H) component liquids paraffin, three (caprylic capric) glyceride, methyl polysiloxane.

Combination (iv)

(A) the two 1-isobutyl-3,5-dimethylhexylphosphoric acid of composition; (B) composition ten polyglycereol list myristinate; (C) composition acrylic arid methacrylic acid alkyl ester copolymer; (D) composition batilol, hydrogenated soya phosphatide, stearic acid, behenyl alcohol; (E) composition concentrated glycerin; (F) composition self-emulsifying type glyceryl monostearate; (G) composition pure water; (H) component liquids paraffin, three (caprylic capric) glyceride, methyl polysiloxane.

Combination (v)

(A) composition list myristyl phosphate ester; (B) composition six polyglycereol four laurate; (C) composition acrylic arid methacrylic acid alkyl ester copolymer; (D) composition capryl alcohol, myristyl alcohol, spermol, cetearyl alcohol, stearyl alcohol; (E) composition concentrated glycerin, dipropylene glycol; (F) composition self-emulsifying type glyceryl monooleate; (G) composition pure water; (H) component liquids paraffin, three (caprylic capric) glyceride, methyl polysiloxane.

Combination (vi)

(A) the two myristyl phosphate ester of composition; (B) composition ten polyglycereol list myristinate; (C) composition acrylic arid methacrylic acid alkyl ester copolymer; (D) composition stearic acid, behenyl alcohol; (E) composition concentrated glycerin; (F) composition self-emulsifying type glyceryl monostearate; (G) composition pure water; (H) composition three (caprylic capric) glyceride, methyl polysiloxane.

Combination (vii)

(A) composition list hexadecanyl phosphate; (B) composition ten polyglycereol list isostearate; (C) composition acrylic arid methacrylic acid alkyl ester copolymer; (D) composition batilol, stearic acid, behenyl alcohol; (E) composition concentrated glycerin; (F) composition self-emulsifying type list myristin; (G) composition pure water; (H) component liquids paraffin, three (caprylic capric) glyceride, methyl polysiloxane.

Combination (viii)

(A) composition double hexadecyl acid ester; (B) composition ten polyglycereol trilaurin; (C) composition acrylic arid methacrylic acid alkyl ester copolymer; (D) composition soybean lecithin, Ovum Gallus domesticus Flavus lecithin, LYSOLECITHIN SUNLECITHIN A; (E) composition concentrated glycerin, dipropylene glycol; (F) composition stearoyl self-emulsifying type glyceryl monostearate; (G) composition pure water; (H) component liquids paraffin, three (caprylic capric) glyceride, methyl polysiloxane.

(I) other compositions

Topical composition of the present invention, as long as the pH usually possessing in faintly acid ~ neutral range, but improves effect, preferred pH5 ~ 7, more preferably pH5.5 ~ 7 from the viewpoint of to the low irritant of skin and pigmentation.In order to regulate the pH of topical composition of the present invention in above-mentioned scope, pH adjusting agent can be coordinated in this composition for external application.As the pH adjusting agent of described cooperation, as long as allow the material used in alkalescence ~ alkalescence, pharmacy or fragrant adornment, there is no particular limitation.As an example, sodium hydroxide, potassium hydroxide, L-arginine, amino-methyl-propanediol, diisopropanolamine (DIPA), triethanolamine etc. can be enumerated.

In the scope not damaging effect of the present invention, various surfactant can also be coordinated as required in creaminess O/W type emulsification composition of the present invention, pigment (dyestuff, pigment), spice, antiseptic, biocide, viscosifier, antioxidant, chelating agen, the various additive such as deodorizer, and wetting agent, UV absorbent, ultraviolet scattering diluent, vitamins, plant extract, skin contraction agent, antiinflammatory, whitening agent, antioxidant, and the known various composition such as cell activator, particularly the accurate pharmaceuticals of medicine etc. of cosmetics or external are applied in the topical composition of skin the known composition coordinated.

Creaminess O/W type emulsification composition of the present invention, the alkyl phosphate containing desired amount according to use and expected effect particularly alkyl phosphate more than 0.2 % by weight, preferably 0.5 ~ 8 % by weight, be more preferably 1 ~ 6 % by weight scope time, even if by preserving for a long time under the labile condition of temperature, also suppress the separation of oil content significantly, stably maintain emulsified state.In addition, creaminess O/W type emulsification composition of the present invention, can also be prepared according to use and make it non-blocking and skin use sense is excellent.Therefore, creaminess O/W type emulsification composition of the present invention, the external preparation such as medicine or accurate pharmaceuticals particularly as the cosmetics or skin (comprising scalp) external that are applied to skin (comprising scalp) is useful.

Creaminess O/W type emulsification composition of the present invention, can be prepared as external preparations such as creamy cosmetics or skin preparations for extenal use (medicine, accurate pharmaceuticals).The form of creamy external preparation has no particular limits, and such as, can enumerate skin moistening fat, massage cream, cleansing cream, adornment foremilk etc.According to the symptom degree etc. of age of user, sex, purposes, skin affected part, according to appropriate amount/time or suitably described external preparation is coated on enterprising the enforcements use of skin by number of times/day.

2, manufacture method

Creaminess O/W type emulsification composition of the present invention, relative to total composition, following compositions is contained: (A) alkyl phosphate more than 0.2 % by weight, (B) polyglyceryl fatty acid ester 0.6 ~ 5 % by weight, (C) acrylic arid methacrylic acid alkyl ester copolymer 0.1 ~ 1 % by weight, (D) amphipathic lipids 0.6 ~ 8 % by weight, (E) polyhydric alcohol 1 ~ 15 % by weight and (F) self-emulsifying type fatty acid glyceride 0.5 ~ 4 % by weight with following ratio, its preparation method has no particular limits, and is prepared described in being preferably as follows.

(1) first, by following mixture heated and stirred, it is made to dissolve equably, obtain non-water system compositions, described mixture comprises above-mentioned (B) composition: polyglyceryl fatty acid ester and (D) composition: amphipathic lipids, (E) composition: polyhydric alcohol, (F) composition: self-emulsifying type fatty acid glyceride and (G) composition: oil content.

(2) then, (A) composition by preparing in addition: alkyl phosphate, (C) composition: acrylic arid methacrylic acid alkyl ester copolymer and (H) composition: aqueous solution (water system compositions) the heating mixing containing moisture, carries out emulsifying with above-mentioned non-water and milk compound at 60 ~ 80 DEG C.Cool afterwards, prepare creaminess O/W type emulsification composition.

Herein, (G) composition: oil content and (H) composition: the mixing ratio of moisture is as described in above-mentioned 1. hurdles.

In the emulsifying step of above-mentioned (2), after mixing above-mentioned non-water and milk compound and aqueous solution (water system compositions), can lower alcohol be coordinated when cooling, the percutaneous absorbtion of alkyl phosphate can be promoted thus further.

There is no particular limitation for the lower alcohol used after the above-mentioned non-water and milk compound of mixing and aqueous solution, usually can suitably select to use from the alcohol of carbon number 1 ~ 6, preferably can enumerate the alcohol that ethanol, propanol and isopropyl alcohol etc. have carbon number 1 ~ 4.Described lower alcohol can be used alone one, or also can combination in any is two or more uses.More preferably ethanol.Now, coordinate lower alcohol, make the ratio with 0.5 ~ 10 % by weight in final emulsification composition 100 % by weight contain lower alcohol, preferably contain lower alcohol with the ratio of 1 ~ 7 % by weight.

And then, in above-mentioned aqueous solution (water system compositions), also can coordinate polyhydric alcohol, the performance of keeping humidity of final emulsification composition and organoleptic attribute can be adjusted to the degree of expectation thus.Polyhydric alcohol can use arbitrarily above-mentioned material herein, when using polyhydric alcohol in the preparation of non-water system compositions, preferably uses the material same or high with its intermiscibility with this polyol phase.

It should be noted that, as the emulsification method of non-water system compositions and aqueous solution (water system compositions), the method using mixer for well-distribution etc. to stir at atmospheric pressure or elevated pressure can be enumerated, also the Emulsion obtained can be used homogenizer miniaturization further as required.

The mixing ratio of non-water system compositions and aqueous solution (water system compositions) has no particular limits, make non-water and milk compound be prepared in the scope of 1 ~ 40 % by weight, preferably 5 ~ 35 % by weight relative to the ratio of every 100 % by weight final emulsification compositions, stable creaminess O/W type emulsification composition can be manufactured thus.

Creaminess O/W type emulsification composition of the present invention, its viscosity has no particular limits, when being applied to the accurate pharmaceuticals of the cosmetics of skin or external used medicine or external, expect to be prepared and make usually to use Brookfield viscometer, use No.4 rotor to be below 50000cps in rotation number 6rpm, the viscosity that measures at 20 DEG C, preferably 6000 ~ 50000cps, more preferably 10000 ~ 45000cps, preferred 15000 ~ 40000cps further, the further scope of preferably 15000 ~ 30000cps, particularly preferably 20000 ~ 25000cps.

The viscosity of creaminess O/W type emulsification composition of the present invention, can by coordinating (A) ~ (F) composition suitably to regulate based on above-mentioned mixing ratio.Such as, when increasing the use level of (C) composition or (D) composition, viscosity has the tendency of rising, and when increasing the use level of (E) composition, viscosity has the tendency of reduction.Therefore, characteristic described in consideration, simultaneously by suitably regulating the use level of (A) ~ (F) composition in the scope of above-mentioned mixing ratio, can be maintained as O/W type emulsification composition stability and there is the creaminess O/W type emulsification composition of desired viscosity.

If the viscosity of creaminess O/W type emulsification composition of the present invention is in above-mentioned scope, then described emulsification composition is easily applied, is had good extensibility and can obtain excellent use sense.

The stable emulsifying method of the creaminess O/W type emulsification composition 3, containing alkyl phosphate

In addition, the invention provides a kind of stable emulsifying method of the O/W type emulsification composition containing alkyl phosphate.The method can be implemented as follows: except using above-mentioned alkyl phosphate, also use above-mentioned acrylic arid methacrylic acid alkyl ester copolymer, polyglyceryl fatty acid ester, amphipathic thing lipid, polyhydric alcohol and self-emulsifying type fatty acid glyceride, moisture, oil content etc., prepare creaminess O/W type emulsification composition.

Specifically, can, by 100 % by weight final O/W type emulsification compositions, following substances be coordinated to implement with following ratio: the ratio of alkyl phosphate more than 0.2 % by weight, preferably 0.5 ~ 8 % by weight, more preferably 1 ~ 6 % by weight; The ratio of polyglyceryl fatty acid ester 0.6 ~ 5 % by weight, preferably 1 ~ 5 % by weight; The ratio of acrylic arid methacrylic acid alkyl ester copolymer 0.1 ~ 1 % by weight; Amphipathic lipids 0.6 ~ 8 % by weight, more preferably 1 ~ 5 % by weight, further preferably 1 ~ 3 % by weight ratio; The ratio of polyhydric alcohol 1 ~ 15 % by weight, more preferably 1 ~ 12 % by weight; And the ratio of the ratio of self-emulsifying type fatty acid glyceride 0.5 ~ 4 % by weight, preferably 1 ~ 3 % by weight.It should be noted that, now, the ratio of the oil content contained in final creaminess O/W type emulsification composition has no particular limits, and preferably 1 ~ 40 % by weight, preferably 2 ~ 35 % by weight, more preferably 5 ~ 30 % by weight.In addition, moisture is the residual components except above-mentioned oil content and other each compositions, has no particular limits, and usually can suitably select to regulate from the scope of 30 ~ 80 % by weight, preferably 40 ~ 70 % by weight, more preferably 45 ~ 65 % by weight.

Stable emulsifying method of the present invention, more specifically can implement as follows: as described belowly prepare creaminess O/W type emulsification composition, make each gradation composition be above-mentioned ratio.

(1) first, by the mixture heated and stirred of polyglyceryl fatty acid ester, amphipathic lipids, oil content, polyhydric alcohol and self-emulsifying type fatty acid glyceride, make it dissolve equably, obtain non-water system compositions.

(2) then, the alkyl phosphate prepared in addition, moisture and the heating of the aqueous solution (water system compositions) containing acrylic arid methacrylic acid alkylester polymers are mixed, at 60 ~ 80 DEG C, carries out emulsifying with above-mentioned non-water system compositions.Cool afterwards, prepare creaminess O/W type emulsification composition.

By preparing creaminess O/W type emulsification composition as mentioned above, the higher dosage form of viscosity can be given with emulsion stability, a kind of emulsification composition can be provided, though described emulsification composition under the high temperature conditions or carry out under the labile condition of temperature long-term preservation also can significantly control separation, stably maintain emulsified state.

4, embodiment

Below provide embodiment etc. and illustrate in greater detail the present invention, but the present invention is not limited to described embodiment.

Embodiment 1 ~ 8

Mixing polyglyceryl fatty acid ester, amphipathic lipids, oil content, polyhydric alcohol and self-emulsifying type fatty acid glyceride, heat and dissolve, prepare uniform non-water system compositions.To in this non-water system compositions, heat while add the water system compositions (aqueous solution) of preparation in addition, be uniformly mixed with mixer for well-distribution at 80 DEG C, alkyl phosphate (heptan alkyl phosphate, Monododecylphosphate or single myristyl phosphate ester), acrylic arid methacrylic acid alkyl ester copolymer and pH adjusting agent etc. are dissolved in Purified Water (pure water) and prepare by described water system compositions.Afterwards, by cooling preparation emulsification composition of the present invention (embodiment 1 ~ 8).Each one-tenth of final composition is grouped into and is shown in table 1.

Being divided respectively by 8 kinds of emulsification compositions (embodiment 1 ~ 8) of preparation gets in 3 Clear glass bottles and jars, terminate keeping under the condition of (i) ~ (iii) after, with the naked eye confirm the appearance character (separation, oil slick, viscosity sharply reduce) of emulsification composition, evaluate according to following determinating reference.Condition (i) ~ (iii) is as described below.

I () takes care of 1 month at 40 DEG C;

(ii) take care of 2 weeks at 60 DEG C;

(iii) 15 cyclic tests (1 circulates 24 hours) at-5 ~ 40 DEG C are repeated.

< determinating reference >

Good: not confirm any one in separation, oil slick and the reduction of viscosity sharply.

Bad: to confirm any one in separation, oil slick or the reduction of viscosity sharply.

Described " separation " refers to because the deterioration oil phase of emulsification system and aqueous phase are divided into biphase phenomenon, so-called " oil slick " is also referred to as creaminess liquid layering (creaming), refer to the reduction of the film-strength due to profit surface, the composition in oil phase becomes the phenomenon that oil droplet floats liquid surface.

Except observing above-mentioned appearance character, measure the viscosity after just preparation.The mensuration of viscosity uses Brookfield viscometer (BL pattern; Tokyo Keiki Inc.'s system), use No.4 rotor to carry out at rotation number 6rpm, at 20 DEG C.Measurement result is shown in following table 1.

Table 1

Ratio (% by weight) in the final emulsification composition 100 % by weight of numeric representation.

In addition, the method same with above-described embodiment 1 ~ 8 is adopted in order to compare, preparation containing the emulsification composition (comparative example 1) of the polyhydric alcohol shown in table 2 and the emulsification composition (comparative example 2) containing lipophilic fatty acid glyceride replacement self-emulsifying type fatty acid monoglyceride, is not supplied to as described above and preserves in stabilisation test.

Emulsification composition for embodiment 1 ~ 8 and comparative example 1 ~ 2 carries out storage stability test, and result is shown in table 1 and table 2.

It should be noted that, as self-emulsifying type glycerol monostearate, use LeodolMS165V (Kao Corp's system); As acrylic arid methacrylic acid alkyl ester copolymer, use PemulenTR-2 (Lubrizol Inc.); As lipophilic glycerol monostearate, use polyglycereol list myristinate (Nikko Chemicals Co., Ltd's system).

Table 2

Applicant states, the present invention illustrates detailed features of the present invention and method detailed by above-described embodiment, but the present invention is not limited to above-mentioned detailed features and method detailed, namely do not mean that the present invention must rely on above-mentioned detailed features and method detailed could be implemented.Person of ordinary skill in the field should understand, any improvement in the present invention, to equivalence replacement and the interpolation of auxiliary element, concrete way choice etc. that the present invention selects component, all drops within protection scope of the present invention and open scope.

Claims (8)

1. a creaminess O/W type emulsification composition, is characterized in that, in the total amount of described emulsification composition, contain (A) ~ (F) composition in following ratio, the viscosity of described emulsification composition at 20 DEG C is 6000 ~ 50000cps:

(A) alkyl phosphate more than 0.2 % by weight, described alkyl phosphate is selected from carbon number 1 ~ 36, preferred carbon number 3 ~ 32, more preferably carbon number 6 ~ 24, the particularly preferably alkyl phosphate of carbon number 8 ~ 18, most preferably heptan alkyl phosphate, Monododecylphosphate, two 1-isobutyl-3,5-dimethylhexylphosphoric acid, single myristyl phosphate ester, two myristyl phosphate ester, single hexadecanyl phosphate, double hexadecyl acid ester, single octadecyl phosphate ester, two octadecyl phosphate ester, and at least one in their salt;

(B) polyglyceryl fatty acid ester 0.6 ~ 5 % by weight;

(C) acrylic arid methacrylic acid alkyl ester copolymer 0.1 ~ 1 % by weight;

(D) amphipathic lipids 0.6 ~ 8 % by weight;

(E) polyhydric alcohol 1 ~ 15 % by weight; And

(F) self-emulsifying type fatty acid glyceride 0.5 ~ 4 % by weight.

2. creaminess O/W type emulsification composition according to claim 1, it is characterized in that, described (B) composition is the ester that carbon number 12 ~ 36, the preferably fatty acid of carbon number 18 ~ 32, more preferably carbon number 24 ~ 28 and the polyglycereol of the degree of polymerization more than 6 are formed.

3. creaminess O/W type emulsification composition according to claim 1 and 2, is characterized in that, described (C) composition has the alkyl of carbon number 5 ~ 40, preferably carbon number 8 ~ 36, more preferably carbon number 16 ~ 24.

4. the creaminess O/W type emulsification composition according to any one of claim 1 ~ 2, it is characterized in that, described (D) composition contains at least one be selected from higher fatty acids, higher alcohol, mono alkyl glyceryl ether, ceramide, glycosyl ceramide, glycolipid, lecithin, lecithin derivative and their analog.

5. the creaminess O/W type emulsification composition according to any one of claim 1 ~ 2, is characterized in that, further containing (G) moisture 30 ~ 80 % by weight, preferably 40 ~ 70 % by weight, more preferably 45 ~ 65 % by weight.

6. the creaminess O/W type emulsification composition according to any one of claim 1 ~ 2, is characterized in that, further containing (H) oil content 1 ~ 40 % by weight, preferably 2 ~ 35 % by weight, more preferably 5 ~ 30 % by weight.

7. a preparation method for creaminess O/W type emulsification composition, is characterized in that, comprises the steps (1) ~ (3), contains following compositions in described emulsification composition relative to total composition in following ratio:

(A) alkyl phosphate more than 0.2 % by weight, (B) polyglyceryl fatty acid ester 0.6 ~ 5 % by weight, (C) acrylic arid methacrylic acid alkyl ester copolymer 0.1 ~ 1 % by weight, (D) amphipathic lipids 0.6 ~ 8 % by weight, (E) polyhydric alcohol 1 ~ 15 % by weight and (F) self-emulsifying type fatty acid glyceride 0.5 ~ 4 % by weight, the viscosity of described emulsification composition at 20 DEG C is 6000 ~ 50000cps

(1) use the compositions containing (B) polyglyceryl fatty acid ester, (D) amphipathic lipids, (E) polyhydric alcohol and (F) self-emulsifying type fatty acid glyceride, prepare the step of non-water and milk compound;

(2) preparation contains the step of the aqueous solution of (A) alkyl phosphate and (C) acrylic arid methacrylic acid alkyl ester copolymer, described alkyl phosphate is selected from carbon number 1 ~ 36, preferred carbon number 3 ~ 32, more preferably carbon number 6 ~ 24, the particularly preferably alkyl phosphate of carbon number 8 ~ 18, most preferably heptan alkyl phosphate, Monododecylphosphate, two 1-isobutyl-3,5-dimethylhexylphosphoric acid, single myristyl phosphate ester, two myristyl phosphate ester, single hexadecanyl phosphate, double hexadecyl acid ester, single octadecyl phosphate ester, two octadecyl phosphate ester, and at least one in their salt, and

(3) described non-water and milk compound is heated with aqueous solution the step mixing and carry out emulsifying.

8. the stable emulsifying method of the creaminess O/W type emulsification composition containing alkyl phosphate, it is characterized in that, comprise the steps (1) ~ (3), in described emulsification composition, contain following compositions relative to total composition in following ratio:

(A) alkyl phosphate more than 0.2 % by weight, (B) polyglyceryl fatty acid ester 0.6 ~ 5 % by weight, (C) acrylic arid methacrylic acid alkyl ester copolymer 0.1 ~ 1 % by weight, (D) amphipathic lipids 0.6 ~ 8 % by weight, (E) polyhydric alcohol 1 ~ 15 % by weight and (F) self-emulsifying type fatty acid glyceride 0.5 ~ 4 % by weight, the viscosity of described emulsification composition at 20 DEG C is 6000 ~ 50000cps

(1) compositions containing (B) polyglyceryl fatty acid ester, (D) amphipathic lipids, (E) polyhydric alcohol and (F) self-emulsifying type fatty acid glyceride is used to prepare the step of non-water and milk compound,

(2) preparation contains the step of the aqueous solution of (A) alkyl phosphate and (C) acrylic arid methacrylic acid alkyl ester copolymer, described alkyl phosphate is selected from carbon number 1 ~ 36, preferred carbon number 3 ~ 32, more preferably carbon number 6 ~ 24, the particularly preferably alkyl phosphate of carbon number 8 ~ 18, most preferably heptan alkyl phosphate, Monododecylphosphate, two 1-isobutyl-3,5-dimethylhexylphosphoric acid, single myristyl phosphate ester, two myristyl phosphate ester, single hexadecanyl phosphate, double hexadecyl acid ester, single octadecyl phosphate ester, two octadecyl phosphate ester, and at least one in their salt, and

(3) described non-water and milk compound is heated with aqueous solution the step mixing and carry out emulsifying.