CN105316386A - 反复电刺激增加超极化活化的环核苷酸门控的阳离子通道(hcn)的单通道开放概率 - Google Patents
反复电刺激增加超极化活化的环核苷酸门控的阳离子通道(hcn)的单通道开放概率 Download PDFInfo
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Abstract
本发明涉及反复的电刺激增加超极化活化的环核苷酸门控的阳离子通道(HCN)的单通道开放概率。可以利用这个特性来改变细胞在超极化状态时的电学特性,从而改变细胞的自动去极化的速度,改变动作电位的频率等等,进而干预或影响HCN通道相关疾病的发生发展过程。
Description
技术领域
本发明涉及反复的电刺激增加超极化活化的环核苷酸门控的阳离子通道(HCN)的单通道开放概率。该发明被用来利用反复的电刺激导致HCN单通道的开放概率增加,从而干预或影响HCN通道相关的疾病发生发展过程。
背景技术
HCN通道的特点是超极化活化的环核苷酸门控的阳离子通道,是在细胞膜复极化并在静息之后才开始激活的,超极化的电压越负,其电流越大,它参与了自动去极化过程。HCN通道最初是在心脏窦房结中发现的,它是窦房结自律性的分子基础。后在神经系统中也发现了它的存在,引起了人们对它在神经系统中的作用研究。很多研究显示它与许多心血管和神经系统的疾病有关。
发明内容
反复的电刺激增加超极化活化的环核苷酸门控的阳离子通道(HCN)的单通道开放概率。这是一个有关HCN通道的新发现,HCN通道是个非失活的通道,只要刺激存在,通道就处于开放,但是只要刺激撤除,通道即关闭。而本发明是刺激-撤除刺激-再刺激反复多次后HCN通道开放概率随着反复刺激的次数增加而增加,直到一个饱和状态(如图1所示,原代培养大鼠大脑皮层神经元的HCN通道开放概率会随着刺激次数的增加而增加。A对原代培养大鼠大脑皮层神经元进行贴附式单通道电流记录电流图示例,记录电压为-90mV。随着记录次数的提升,HCN通道开放概率逐渐增加。B对单通道记录所得电流进行统计,用单通道开放概率对刺激次数作图,随着刺激的进行开放概率增加,最终达到相对稳态)。这是一个完全新的特性。可以利用这个特性来改变细胞在超极化状态时的电学特性,从而改变细胞的自动去极化的速度,改变动作电位的频率等等,从而干预相关疾病的发生发展过程。
附图说明
图1中的A为对原代培养大鼠大脑皮层神经元进行贴附式单通道电流记录电流图,B为单通道开放概率的统计图。
Claims (2)
1.反复的电刺激可以增加超极化活化的环核苷酸门控的阳离子通道(HCN)的单通道开放概率。
2.权利要求1所述的在生物学和医学上的用途,其特征在于:利用反复的电刺激导致HCN单通道的开放概率增加,从而干预或影响HCN通道相关的疾病发生发展过程。
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Citations (1)
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CN101970014A (zh) * | 2007-07-26 | 2011-02-09 | 通用电气医疗集团英国有限公司 | 包含超极化的13c-乳酸盐的成像介质及其用途 |
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CN101970014A (zh) * | 2007-07-26 | 2011-02-09 | 通用电气医疗集团英国有限公司 | 包含超极化的13c-乳酸盐的成像介质及其用途 |
Non-Patent Citations (3)
Title |
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T. A. SIMEONE1等: "Single channel properties of hyperpolarization-activated cation currents in acutely dissociated rat hippocampal neurones", 《J PHYSIOL》 * |
THON S 等: "Elementary Functional Properties of Single HCN2 Channels", 《BIOPHYSICAL JOURNAL》 * |
章鹏宇等: "超极化激活环核苷酸门控通道的研究展望", 《山西医科大学学报》 * |
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