CN105311114A - Traditional Chinese medicine composition for treating halitosis - Google Patents
Traditional Chinese medicine composition for treating halitosis Download PDFInfo
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- CN105311114A CN105311114A CN201510867685.4A CN201510867685A CN105311114A CN 105311114 A CN105311114 A CN 105311114A CN 201510867685 A CN201510867685 A CN 201510867685A CN 105311114 A CN105311114 A CN 105311114A
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Abstract
The invention relates to a medical preparation and in particular relates to a traditional Chinese medicine composition for treating halitosis. The composition consists of active ingredients and medically acceptable adjuvant materials and is characterized in that the active ingredients are volatile oil and aqueous extracts which are extracted from the following raw medicinal materials in parts by weight: 26-30 parts of Chinese mosla herb, 15-20 parts of perilla leaf, 8-12 parts of cablin potchouli herb, 10-15 parts of weeping forsythia capsule, 8-12 parts of peppermint and 12-15 parts of fineleaf schizonepeta herb, wherein the aqueous extracts are obtained by extracting herb residues, which are obtained after volatile oil extraction of the raw materials, by adding water. The traditional Chinese medicine composition provided by the invention not only is less in number of medicines and easily-controlled in quality, but also is significant in curative effect.
Description
Technical field
The present invention relates to medicinal preparation, be specifically related to containing the pharmaceutical preparation not determining structure from plant, said preparation can be used for treating halitosis.
Background technology
Halitosis means in mouth gives vent to anger smelly dirty, can be other people and smells, oneself can feel and or can not discover person, mostly be a symptom of mouth, nose, laryngopharyngeal diseases or some other disease, have a strong impact on social communication and the mental health of people.Investigation display, the current halitosis prevalence of China is 27.5%, and western countries are 50%, and the whole world about has the people of 10%-65% once to suffer from halitosis.Along with the raising of people's living standard and the raising of health perception, get more and more with the patient that halitosis is chief complaint, cause the attention of clinicist.
The root of halitosis is the mist causing the sulfide of halitosis, methanthiol and trimethyl sulfur three kinds of compounds.Physiological halitosis is Exfoliative cells, staphylococcus and the putrefactive fermentation of food residual residue mainly, produces too much VSC (sulfide VolatileSulfurCompounds is called for short VSC) and causes halitosis.Pathologic halitosis derives from the untreated dental caries in oral cavity, residual crown and root, ill fitting prosthesis, abnormal anatomical structure, gingivitis, periodontitis and diseases of oral mucosa etc. and causes internal environment of oral cavity to change, and VSC increases, and produces halitosis; Pathologic systemic disease, such as respiratory tract, digestive tract disease, diabetes, liver cirrhosis, cyanide poisoning etc. also can produce the halitosis of different odor.
Clinically, because the drug selectivity of western medical treatment halitosis is many, clinical effect effect is fast, therefore multiplex western medical treatment halitosis.Conventional collutory generally containing antibacterial action agent metronidazole, tinidazole, hibitane, also comprises chlorine-containing compound, hydrogen peroxide, sodium salt, zinc salt etc.But western medical treatment halitosis has certain side effect, as easy recurrence, the persistent period is short, easily produces drug resistance etc., and sometimes can not treat clinically without the halitosis of the obvious cause of disease.Comparatively speaking, Chinese traditional treatment halitosis has rich experience, as treatment halitosis in " Chinese medicine voluminous dictionary ", wherein just there is " Herba Pogostemonis decocts soup, constantly rinsing the mouth " side, treatment stomach internal organs accumulated heat halitosis manna drink plus-minus, treatment Liver Channel intrinsic heat halitosis Herba Sidae Rhombifoliae soup, treatment spleen-heat and taste deficiency-heat halitosis Liujunzi Tang, treatment gallbladder meridian humid halitosis Decoction of Gentiana for Purging the Liver-fire etc., can obtain certain therapeutic effect.Publication number is that CN102218132A application for a patent for invention discloses a kind of Chinese medicine composition for the treatment of epistaxis, said composition is made up of 17 taste Chinese medicines such as Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, although the accompanied symptoms such as halitosis and halitosis (see description [0009] section) can be treated, but the prescription of said composition is complicated, flavour of a drug are many, and the effect for the treatment of halitosis is also undesirable.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition for the treatment of halitosis, and said composition not only flavour of a drug is few, and quality easily controls, and evident in efficacy.
The technical scheme that the present invention solves the problems of the technologies described above is:
A kind of Chinese medicine composition for the treatment of halitosis, said composition is made up of effective ingredient and medically acceptable adjuvant, it is characterized in that, described effective ingredient is volatile oil and the water extract of the crude drug extraction of following weight portion: Herba Moslae 26-30 weight portion, Folium Perillae 15-20 weight portion, Herba Pogostemonis 8-12 weight portion, Fructus Forsythiae 10-15 weight portion, Herba Menthae 8-12 weight portion, Herba Schizonepetae 12-15 weight portion; Wherein, described water extract adds water extraction by the medicinal residues after described crude drug extracts volatile oil to obtain.
The optimum proportioning of described crude drug is: Herba Moslae 28 weight portion, Folium Perillae 18 weight portion, Herba Pogostemonis 10 weight portion, Fructus Forsythiae 12 weight portion, Herba Menthae 10 weight portion, Herba Schizonepetae 13 weight portion.
The Chinese medicine composition for the treatment of halitosis of the present invention can be gargarism or buccal tablet.
Above-mentioned volatile oil can adopt traditional way of distillation to extract, and also can adopt modern supercritical fluid CO
2extraction.
The above-mentioned way of distillation concrete steps as follows: take described crude drug, add the water soaking 1 ~ 2 hour of 10 times amount, 2 ~ 3 hours vapor distillation extraction times, collect volatile oil.
Above-mentioned supercritical fluid CO
2the concrete steps of extraction are as follows: take described crude drug, pulverize, and cross 20 mesh sieves, are placed in supercritical extraction unit, adjustment extraction temperature is 35-40 DEG C, and extracting pressure is 20MPa, and resolve pressure 5MPa, flow is 20-25L/h, cycling extraction 2h, decompression, collects volatile oil.
Above-mentioned water extract can adopt conventional method preparation, and the method that the present inventor recommends is as following two kinds:
Method one: extract the medicinal residues after volatile oil, add 10 times of water gagings, decocts 1 hour, extracts secondary, merging filtrate, and adding ethanol to the volumetric concentration of alcohol after concentrated is 50%, and hold over night, filters, reclaim ethanol and concentrated solution to containing crude drug amount 1g/ml, to obtain final product.
Method two: extract the medicinal residues after volatile oil, add 10 times of water gagings, decocts 1 hour, extracts secondary, merging filtrate, and adding ethanol to the volumetric concentration of alcohol after concentrated is 50%, and hold over night, filters, and reclaims ethanol, concentrates, dry, pulverize, to obtain final product.
The Chinese medicine composition for the treatment of halitosis of the present invention is made up of Fructus Forsythiae, Herba Moslae, Herba Menthae, Herba Pogostemonis, Folium Perillae and Herba Schizonepetae, wherein, Herba Moslae, Folium Perillae removing dampness by means of aromatics are monarch drug, and Herba Pogostemonis, Fructus Forsythiae removing dampness heat clearing away are ministerial drug, on Herba Schizonepetae, the light Chhnang of Herba Menthae, the merit having removing dampness heat clearing away concurrently is adjuvant.
Beneficial effect of the present invention is further illustrated below by way of clinical experiment.
1, experimental subject and grouping: outpatient 150 example being selected from certain hospital, is divided into treatment group 1, treatment group 2 and matched group at random, often organizes each 50 examples.The course of disease of above-mentioned patient 1 year ~ 3 years, average 2 years; 25 ~ 60 years old age, average 41 years old.
2, case selection standard:
The model adopting American I nterscan company to produce is the concentration that the portable halimeter of RH17K (Halimeter) directly measures patient's implication medium sulphide content, concentration is more than or equal to 200ppb, and without obvious otorhinolaryngology, respiratory system and other systemic disease person inclusive criteria.
3, exclusion standard:
Get rid of and suffer from membrane disease, test in first 1 month and use antibiotic and compliance difference person.
4, Therapeutic Method:
(1) method of administration:
Treatment group 1 uses the gargarism of following embodiment 1, and every day is early, middle and late respectively once, each containing gargling after 2-3 minute, continuously treatment one month;
Treatment group 2 uses the buccal tablet of following embodiment 4, every 6 hours a slices, and treatment one month continuously;
The oral publication number of matched group is the medicine soup of CN102218132A application for a patent for invention embodiment 2, every day potion, every agent divide three times oral, continuously treatment one month.
5, observation of curative effect
Efficacy assessment standard: adopt the reference instrument RH17K implication of internationally recognized detection implication to analyze detector and detect, everyone measures 3 times, averages.
(1) effective: implication medium sulphide content lowering of concentration is to being less than 100ppb.
(2) take a turn for the better: implication medium sulphide content lowering of concentration amplitude is 50% ~ 80%.
(3) invalid: implication medium sulphide content lowering of concentration amplitude is less than 50%.
Statistical procedures:
Total data adopts SPSS17.0 statistics software to carry out statistical analysis.
Experimental result:
Volume fraction (ppb) testing result of table 1 oral volatile sulfur compounds (VSCS)
| Group | Effective | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group 1 | 41 | 5 | 4 | 92％ |
| Treatment group 2 | 40 | 7 | 3 | 94％ |
| Matched group | 25 | 12 | 13 | 74％ |
As shown in Table 1, the total effective rate for the treatment of group 1 and treatment group 2 is respectively 92% and 94%, apparently higher than the total effective rate of matched group.The X 2 test of two groups of data Average value compare, P<0.05, difference has statistical significance.
Conclusion: compare with matched group, the Be very effective of traditional Chinese medicine composition for treating halitosis of the present invention.
Detailed description of the invention
Embodiment 1
1, the preparation of volatile oil:
Take Herba Moslae 28g, Folium Perillae 18g, Herba Pogostemonis 10g, Fructus Forsythiae 12g, Herba Menthae 10g, Herba Schizonepetae 13g, add 910ml distilled water immersion 1.5h, vapor distillation extracts 2.5h, collects volatile oil, for subsequent use.
2, alcohol dissolubility herb liquid preparation:
Medicinal residues after distillation extraction are added 10 times of water gagings, decoct 1 hour, extract secondary, merging filtrate, the volumetric concentration adding ethanol to 50% alcohol after concentrated is 50%, hold over night, filters, reclaim ethanol concentrated solution to containing crude drug amount 1g/ml, obtain alcohol dissolubility herb liquid, for subsequent use.
3, gargarism is prepared into
Get volatile oil, add 2g Polysorbate, stir and obtain oiliness liquid; Get alcohol dissolubility herb liquid, add glycerol 3g and polyvidon 1g and mix, add water to 100g, stir and obtain aqueous solution; Get oiliness liquid slowly to add in aqueous solution, stir, add qs pH adjuster and be adjusted to neutrality, be diluted with water to 1000ml, carry out with homogenizer after fully dissolving secondary homogeneous after canned, obtain gargarism of the present invention.
Embodiment 2
1, the preparation of volatile oil:
Take Herba Moslae 26g, Folium Perillae 19g, Herba Pogostemonis 11g, Fructus Forsythiae 12g, Herba Menthae 11g, Herba Schizonepetae 12g, pulverize, cross 20 mesh sieves, be placed in supercritical extraction unit, adjustment extraction temperature is 35-40 DEG C, and extracting pressure is 20MPa, resolves pressure 5MPa, flow is 20-25L/h, cycling extraction 2h, decompression, collects volatile oil.
2, alcohol dissolubility herb liquid preparation:
By the medicinal residues after supercritical extraction, add 10 times of water gagings, decoct 1 hour, extract secondary, merging filtrate, adding ethanol to the volumetric concentration of alcohol after concentrated is 50%, and hold over night, filters, reclaim ethanol concentrated solution to containing crude drug amount 1g/ml, obtain alcohol dissolubility herb liquid, for subsequent use.
3, gargarism is prepared into
Get volatile oil, add 2g Polysorbate, stir and obtain oiliness liquid; Get alcohol dissolubility herb liquid, add glycerol 3g and polyvidon 1g and mix, add water to 100g, stir and obtain aqueous solution; Get oiliness liquid slowly to add in aqueous solution, stir, add qs pH adjuster and be adjusted to neutrality, be diluted with water to 1000ml, carry out with homogenizer after fully dissolving secondary homogeneous after canned, obtain gargarism of the present invention.
Embodiment 3
1, the preparation of effective ingredient:
Take Herba Moslae 30g, Folium Perillae 16g, Herba Pogostemonis 9g, Fructus Forsythiae 12g, Herba Menthae 11g, Herba Schizonepetae 13g, add 910ml distilled water immersion 1.5h, vapor distillation extracts 2.5h, collects volatile oil, for subsequent use.
2, alcohol dissolubility herb liquid preparation:
Medicinal residues after distillation extraction are added 10 times of water gagings, decoct 1 hour, extract secondary, merging filtrate, adding ethanol to the volumetric concentration of alcohol after concentrated is 50%, and hold over night, filters, and reclaims ethanol, concentrated, dry, pulverize, obtains water solublity dried cream powder, for subsequent use.
3, buccal tablet is prepared into
Get β mono-cyclodextrin 2g, put in beaker, add water 25ml, heating for dissolving, be cooled to 50 DEG C, drip above-mentioned volatile oil, constant temperature stirs 1.5 hours, cooling, adularescent Precipitation, completely rear sucking filtration to be precipitated.Precipitation dehydrated alcohol 3ml divides 3 washings, and the nearly oil stains-less to surface, puts precipitation in exsiccator dry, obtain β mono-cyclodextrin clathrate.
Molten dried cream powder of fetching water adds cane sugar powder, citric acid wet granulation, 80 DEG C of dryings, and granulate, adds β mono-cyclodextrin clathrate and magnesium stearate, tabletting.
Embodiment 4
1, the preparation of effective ingredient:
Take Herba Moslae 27g, Folium Perillae 20g, Herba Pogostemonis 8g, Fructus Forsythiae 13g, Herba Menthae 11g, Herba Schizonepetae 12g, pulverize, cross 20 mesh sieves, be placed in supercritical extraction unit, adjustment extraction temperature is 35-40 DEG C, and extracting pressure is 20MPa, resolves pressure 5MPa, flow is 20-25L/h, cycling extraction 2h, decompression, collects volatile oil.
2, alcohol dissolubility herb liquid preparation:
By the medicinal residues after supercritical extraction, add 10 times of water gagings, decoct 1 hour, extract secondary, merging filtrate, being condensed into by Aqueous extracts containing crude drug amount is the medicinal liquid of 1g/ml, adding ethanol to the volumetric concentration of alcohol is 50%, hold over night, filters, reclaim ethanol, concentrated, dry, pulverize, obtain water solublity dried cream powder, for subsequent use.
3, buccal tablet is prepared into
Get β mono-cyclodextrin 2g, put in beaker, add water 25ml, heating for dissolving, be cooled to 50 DEG C, drip above-mentioned volatile oil, constant temperature stirs 1.5 hours, pours out supernatant, cooling, adularescent Precipitation, completely rear sucking filtration to be precipitated.Precipitation dehydrated alcohol 3ml divides 3 washings, and the nearly oil stains-less to surface, puts precipitation in exsiccator dry, obtain β mono-cyclodextrin clathrate.
Molten dried cream powder of fetching water adds cane sugar powder, citric acid wet granulation, 80 DEG C of dryings, and granulate, adds β mono-cyclodextrin clathrate and magnesium stearate, tabletting.
Claims (7)
1. treat the Chinese medicine composition of halitosis for one kind, said composition is made up of effective ingredient and medically acceptable adjuvant, it is characterized in that, described effective ingredient is volatile oil and the water extract of the crude drug extraction of following weight portion: Herba Moslae 26-30 weight portion, Folium Perillae 15-20 weight portion, Herba Pogostemonis 8-12 weight portion, Fructus Forsythiae 10-15 weight portion, Herba Menthae 8-12 weight portion, Herba Schizonepetae 12-15 weight portion; Wherein, described water extract adds water extraction by the medicinal residues after described crude drug extracts volatile oil to obtain.
2. a kind of Chinese medicine composition for the treatment of halitosis as claimed in claim 1, it is characterized in that, described effective ingredient is volatile oil and the aqueous extract of the crude drug extraction of following weight portion: Herba Moslae 28 weight portion, Folium Perillae 18 weight portion, Herba Pogostemonis 10 weight portion, Fructus Forsythiae 12 weight portion, Herba Menthae 10 weight portion, Herba Schizonepetae 13 weight portion.
3. a kind of Chinese medicine composition for the treatment of halitosis as claimed in claim 1, it is characterized in that, described Chinese medicine composition is gargarism or buccal tablet.
4. the Chinese medicine composition of the treatment halitosis as described in claim 1,2 or 3, it is characterized in that, described volatile oil is obtained by following methods: take described crude drug, adds the water soaking 1-2 hour of 10 times amount, vapor distillation extracts 2-3 hour, collects volatile oil.
5. the Chinese medicine composition of the treatment halitosis as described in claim 1,2 or 3, it is characterized in that, described volatile oil is obtained by following methods: take described crude drug, pulverizes, cross 20 mesh sieves, be placed in supercritical extraction unit, adjustment extraction temperature is 35-40 DEG C, and extracting pressure is 20MPa, resolve pressure 5MPa, flow is 20-25L/h, cycling extraction 2h, and volatile oil is collected in decompression.
6. the Chinese medicine composition for the treatment of halitosis as claimed in claim 1 or 2, it is characterized in that, described water extract is obtained by following methods: get the medicinal residues after extracting volatile oil, add 10 times of water gagings, decoct 1 hour, extract secondary, merging filtrate, adding ethanol to the volumetric concentration of alcohol after concentrated is 50%, hold over night, filtration, reclaims ethanol and concentrated solution extremely contains crude drug amount 1g/ml, to obtain final product.
7. the Chinese medicine composition for the treatment of halitosis as claimed in claim 1 or 2, it is characterized in that, described water extract is obtained by following methods: get the medicinal residues after extracting volatile oil, add 10 times of water gagings, decoct 1 hour, extract secondary, merging filtrate, adding ethanol to the volumetric concentration of alcohol after concentrated is 50%, hold over night, filter, reclaim ethanol, concentrated, dry, pulverize, to obtain final product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510867685.4A CN105311114A (en) | 2015-12-01 | 2015-12-01 | Traditional Chinese medicine composition for treating halitosis |
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| CN201510867685.4A CN105311114A (en) | 2015-12-01 | 2015-12-01 | Traditional Chinese medicine composition for treating halitosis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113491660A (en) * | 2021-08-24 | 2021-10-12 | 厦门恒新万鼎电子科技有限公司 | Chinese herbal medicine mouthwash and preparation method thereof |
-
2015
- 2015-12-01 CN CN201510867685.4A patent/CN105311114A/en active Pending
Non-Patent Citations (4)
| Title |
|---|
| 卢颖: "药用花卉-连翘", 《中华养生保健》 * |
| 张大宁: "《中医肾病学大辞典》", 31 December 1993, 中国医药科技出版社 * |
| 杨朝华: "小验方六则", 《农村百事通》 * |
| 郑修湘: "《大众健康常识》", 31 December 2008, 海潮摄影艺术出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113491660A (en) * | 2021-08-24 | 2021-10-12 | 厦门恒新万鼎电子科技有限公司 | Chinese herbal medicine mouthwash and preparation method thereof |
| CN113491660B (en) * | 2021-08-24 | 2023-05-09 | 厦门恒新万鼎电子科技有限公司 | Chinese herbal medicine mouthwash and preparation method thereof |
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