CN105287440A - Permeation type pharmaceutic thin film patch - Google Patents
Permeation type pharmaceutic thin film patch Download PDFInfo
- Publication number
- CN105287440A CN105287440A CN201410273505.5A CN201410273505A CN105287440A CN 105287440 A CN105287440 A CN 105287440A CN 201410273505 A CN201410273505 A CN 201410273505A CN 105287440 A CN105287440 A CN 105287440A
- Authority
- CN
- China
- Prior art keywords
- medicament
- patch
- film patch
- nanorize
- thin film
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention relates to a permeation type pharmaceutic thin film patch. The permeation type pharmaceutic thin film patch comprises a thin film patch, a medicament cementing layer and a releasing layer, wherein the thin film patch is in the shape of a patch and is provided with an upper surface and a lower surface; two auxiliary patches are arranged on the lower surface; nanosizing medicament is mixed with medical pressure sensitive adhesives, the mixture coats the lower surface of the thin film patch to form the medicament cementing layer; and the releasing layer is adhered to the medicament cementing layer. When the permeation type pharmaceutic thin film patch is used, after the releasing layer is torn off, the thin film patch is adhered to the skin of a patient, at the moment, the auxiliary patches are pressed tightly so that the thin film patch can be smoothly adhered to the skin of the patient, and then the auxiliary patches can be removed; and the nanosizing medicament can be absorbed to the body of the patient through a skin contact position in a permeation mode, and a treatment effect can be achieved. The permeation type pharmaceutic thin film patch has the effect that the medicament can be directly absorbed by the patient through the skin in the permeation mode, the patient does not need to orally take the medicament or be injected with the medicament, but the optimal continuous treatment effect can be achieved.
Description
Technical field
The present invention has about a kind of infiltration type pharmaceutical films paster, and it is by the medicament through nanorize process, after mixing, coats on film patch and forms medicament cementing layer with the medical pressure-sensing glue of tool stickiness.During use, film patch is affixed on health, makes the medicament of nanorize be able to penetration mode and be absorbed in patient body through contact skin place, the effect of continued treatment can be reached.
Background technology
By on traditional medical, in patient medication, the normal administering mode used, mainly contains following three kinds: (1) oral medicine mode: medicament is directly oral to patient with forms such as pill, lozenge, capsule or liquid medicine at present; (2) injected s. c: by medicament with syringe direct injection in patient body; (3) skin absorption pattern: utilize stype or smear mode, makes skin absorb medicament.
But, though these three kinds of methods by pharmacy application with it the patient, can also exist following defect:
(1) oral medicine mode; because needs are taken medicine on time; patient Chang Hui ignores administration time; and forget and take medicine; therefore often therapeutic efficiency cannot be arrived; and for Most patients, especially old and young patient often often has the problem of dysphagia for oral medicine, therefore Oral administration is obviously not satisfactory.
(2) injected s. c, be by medicament with syringe direct injection in patient body, although quite quick, so it needs care-giving professional's injection injection, for quite inconvenience patient, and should be noted that administration time equally, young patient repels especially for having an injection.
(3) skin absorption pattern: utilize stype or smear mode, can pass through skin and absorb medicament, the mode of smearing only is suitable for the symptoms such as the wound of skin or dermatosis usually; And the symptom that stype also can only be ached for health at the stype sold on the market at present, and other medicaments cannot be reached the effect controlling material in the mode of stype, and traditional drugs is distributed on skin and pasted for a long time, patient skin also can be caused irritated uncomfortable.
Inventor is specially to the correlational study of medical aspect, know very well the defect of administration on traditional medical, so be do one's utmost to think hard solution, and rely on specialty itself and working experience for many years, coordinate again after going through test for several times, correction and improvement, finally have infiltration type pharmaceutical films paster of the present invention to be born.
Summary of the invention
The invention relates to a kind of infiltration type pharmaceutical films paster, it comprises: film patch, medicament cementing layer, from shape layer and auxiliary patch.Wherein this film patch is the lamellar that resin type pressure-sensing glue adhesive plaster is made, its tool upper surface and lower surface; First reorganize and outfit required medicament, then by medicament after nanorize process, after mixing with the medical pressure-sensing glue of tool stickiness, the lower surface coating film patch forms medicament cementing layer; From shape layer for two-chip type designs, these two invest on medicament cementing layer from shape laminating, avoid medicament be stained with glutinous or pollute.During use, sequentially tear two and be affixed on patient skin by film patch, then removed by auxiliary patch after shape layer, this auxiliary patch can make the more smooth-going laminating of this film patch; This medicament cementing layer directly contacts by glued membrane paster with patient skin, and the medicament of nanorize is able to, and penetration mode is continual through contact skin place is absorbed in patient body, can reach the effect of long term administration.
Therefore, the object of the invention is to use infiltration type pharmaceutical films mount technology, after the medicament of nanorize is mixed with medical pressure-sensing glue, penetration mode can be utilized to make patient utilize skin directly to absorb medicament, do not need oral or injection medicament, the optimal efficacy for the treatment of can be reached, and the inconvenience that patient uses can not be caused, and this film patch has air permeable effect, its adhering effect is splendid, the sustainable patient skin that sticks in reaches more than 72 hours, and can provide continual effect continued medication; And this infiltration type pharmaceutical films paster is separately provided with tearing end at two end faces from shape layer and two auxiliary patch, stick on hand except avoiding being stained with when pasting, more can make film patch smooth fit on skin surface, not easily cause and come off.
Accompanying drawing explanation
Fig. 1 is three-dimensional exploded view of the present invention;
Fig. 2 is schematic flow sheet of the present invention;
Fig. 3 is that flow chart reorganized and outfit by medicament of the present invention;
Fig. 4 is medicament nanorize flow chart of the present invention;
Fig. 5 is mixing viscose flow chart of the present invention;
Fig. 6 is coating glued membrane flow chart of the present invention;
Fig. 7 is use schematic diagram of the present invention.
Description of reference numerals: 10-film patch; 101-upper surface; 102-lower surface; 11-medicament cementing layer; 12-is from shape layer; 120-first is from shape layer; 121-second is from shape layer; 1201-tearing end; 1211-tearing end; 13-auxiliary patch; 130-first auxiliary patch; 131-second auxiliary patch; 1301-tearing end; 1311-tearing end; 1-medicament is reorganized and outfit; 2-medicament nanorize; 3-mixing viscose; 4-is coated with glued membrane; The medication of 14-physician's prescription; 15-nonprescription drug; 20-nanorize molecular agent; The medical pressure-sensing glue of 30-; 31-glues together medicament; 5-skin.
Detailed description of the invention
Be below embodiment and test data etc. thereof, but content of the present invention is not limited to the scope of these embodiments.
First, referring to Fig. 1, is three-dimensional exploded view of the present invention, and it is by film patch 10, medicament cementing layer 11, formed from shape layer 12 and auxiliary patch 13.This film patch 10 is that resin type pressure-sensing glue adhesive plaster is made, and has upper surface 101 and lower surface 102; Medicament cementing layer 11, after being mixed with the medical pressure-sensing glue (not shown) of tool stickiness by nanorize medicament, coats the lower surface 102 of film patch 10; Be attached at medicament cementing layer 11 from shape layer 12, it has first from shape layer 120 and second from shape layer 121, and is provided with tearing end 1201 and 1211 respectively at a wherein end face; Auxiliary patch 13 has the first auxiliary patch 130, second auxiliary patch 131, and it is attached on the upper surface 101 of film patch 10, and is provided with tearing end 1301 and 1311 respectively at a wherein end face.
Then, referring to shown in Fig. 2, is schematic flow sheet of the present invention, and infiltration type pharmaceutical films paster of the present invention had four stages:
(1) medicament reorganizes and outfit 1: reorganized and outfit for subsequent use by the medicament or nutriment that are applicable to various symptom curative effect.
(2) medicament nanorize 2: all medicaments are given nanorize and is treated as nanorize molecular agent.
(3) viscose 3 is mixed: the medical pressure-sensing glue through nanorize molecular agent and tool stickiness is mixed into gummed medicament.
(4) glued membrane 4 is coated with: be spread evenly across on the inner surface of film patch by gummed medicament.
Then, referring to Fig. 3, is that flow chart reorganized and outfit by medicament of the present invention, and this medicament 1 stage of reorganizing and outfit prepares required medication according to patients symptomatic, as medicaments such as physician's prescription medication 14 or nonprescription drugs 15, reorganized and outfit for subsequent use.
Secondly, referring to Fig. 4, is medicament nanorize flow chart of the present invention, this medicament nanorize 2 stage be by physician's prescription medication 14 or nonprescription drug 15 after nanorize, become nanorize molecular agent 20.
Then, referring to Fig. 5, is mixing viscose flow chart of the present invention, and this mixing viscose 3 stage, by after the nanorize molecular agent 20 after nanorize and medical pressure-sensing glue 30 Homogeneous phase mixing, forms gummed medicament 31.
Referring to Fig. 6 again, is coating glued membrane flow chart of the present invention, and the gummed medicament 31 after Homogeneous phase mixing is coated on the lower surface 102 of the film patch 10 of tool breathability by this coating glued membrane 4 stage, forms medicament cementing layer 11 (not shown).
During use, refer to Fig. 7, it is use schematic diagram of the present invention, first finger is gently pinched tearing end 1201 tear first from shape layer 120 after (please look back again Fig. 1 shown in), by the support of the first auxiliary patch 130, film patch 10 can be made to keep smooth, then will the medicament cementing layer 11 of film patch 10 be affixed on patient skin 5, now after light press first auxiliary patch 130, make that one end of film patch 10 is smooth-going to be obedient on skin 5, relend and by tearing end 1301, first auxiliary patch 130 is removed; Then light tearing pull end 1211 is torn second from shape layer 121, after making film patch 10 fit after pressing the second auxiliary patch 131 again, relend and by tearing end 1311, second auxiliary patch 131 is removed, now this film patch 10 can completely be attached on patient skin 5, and directly contact by medicament cementing layer 11 with patient skin 5, make the medicament through nanorize, can be absorbed in patient body through skin 5 contact position by penetration mode, the effect for the treatment of can be reached.
Therefore, infiltration type pharmaceutical films mount technology is used by the present invention, after the medicament of nanorize is mixed with medical pressure-sensing glue, penetration mode can be utilized to make patient utilize skin directly to absorb medicament, do not need oral or injection medicament, can reach the optimal efficacy for the treatment of, and overturn the method for traditional medical administration completely, be a quantum jump in fact.
So utilize infiltration type pharmaceutical films mount technology of the present invention, have the following advantages:
(1) utilize infiltration type pharmaceutical films paster to substitute medicinal preparation for oral administration, reach effect of SM, especially can solve the dysphagia of problem old and young patient often often has to(for) oral medicine.
(2) utilize infiltration type pharmaceutical films paster to substitute subcutaneous injection medicament mode, do not need care-giving professional's injection injection, reduce the discomfort that patient has an injection.
(3) this film patch has air permeable effect, and medical pressure-sensing glue tool height adhesion, fabulous skin adhesion, do not drop in water, peel off not cull and do not cause skin tension, and have two-chip type from the design of shape layer and auxiliary patch, adhering effect is splendid, the sustainable patient skin that sticks in reaches more than 72 hours, and can provide continual continued treatment effect.
In sum, the present invention uses infiltration type pharmaceutical films mount technology, after the medicament of nanorize is mixed with medical type pressure-sensing glue, penetration mode is utilized to make patient utilize skin directly to absorb medicament, do not need oral or injection medicament, the optimal efficacy for the treatment of can be reached, and this film patch has air permeable effect, can continue for a long time to stick on patient skin, can not come off, and continual continued treatment effect can be provided, for having the invention of progressive, and not seeing publication, reason has met the patent requirement of invention, therefore proposes patent application in accordance with the law.
Above-described embodiment is only be described the preferred embodiment of the present invention; not scope of the present invention is limited; under not departing from the present invention and designing the prerequisite of spirit; the various distortion that those of ordinary skill in the art make technical scheme of the present invention and improvement, all should fall in protection domain that claims of the present invention determines.
Claims (6)
1. an infiltration type pharmaceutical films paster, its have film patch, medicament cementing layer, two from shape layer and two auxiliary patch, this film patch is the lamellar paster that resin type pressure-sensing glue adhesive plaster is made, and has upper surface and lower surface; Medicament cementing layer coats the lower surface of film patch after being mixed with the medical pressure-sensing glue of tool stickiness by nanorize medicament; Invest below medicament cementing layer from shape laminating, have first from shape layer and second from shape layer, and be provided with tearing end respectively at a wherein end face; Auxiliary patch has the first auxiliary patch, the second auxiliary patch, and it is attached on the upper surface of film patch, and is provided with tearing end respectively at a wherein end face, and its method for making at least comprises the following step:
(1) medicament is reorganized and outfit;
(2) medicament nanorize;
(3) viscose is mixed;
(4) glued membrane is coated with.
2. infiltration type pharmaceutical films paster as claimed in claim 1, is characterized in that, step reorganized and outfit by this medicament is reorganized and outfit for subsequent use by the medicament being applicable to various symptom curative effect.
3. infiltration type pharmaceutical films paster as claimed in claim 1, is characterized in that, this medicament nanorize step has given nanorize be treated as nanorize molecular agent by having reorganized and outfit medicament.
4. infiltration type pharmaceutical films paster as claimed in claim 1, it is characterized in that, this mixing viscose step is that the medical type pressure-sensing glue through nanorize molecular agent and tool stickiness is mixed into gummed medicament.
5. infiltration type pharmaceutical films paster as claimed in claim 1, is characterized in that, this coating glued membrane step is spread evenly across on the lower surface of film patch by gummed medicament.
6. infiltration type pharmaceutical films paster as claimed in claim 1, it is characterized in that, the nanorize medicament of this medicament cementing layer can be the medicine of nonprescription drug, physician's prescription medicine or other tool curative effects.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410273505.5A CN105287440A (en) | 2014-06-18 | 2014-06-18 | Permeation type pharmaceutic thin film patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410273505.5A CN105287440A (en) | 2014-06-18 | 2014-06-18 | Permeation type pharmaceutic thin film patch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105287440A true CN105287440A (en) | 2016-02-03 |
Family
ID=55185738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410273505.5A Pending CN105287440A (en) | 2014-06-18 | 2014-06-18 | Permeation type pharmaceutic thin film patch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105287440A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6129929A (en) * | 1998-10-30 | 2000-10-10 | Noven Pharmaceuticals, Inc. | Patch applicator |
| WO2002089717A1 (en) * | 1999-08-03 | 2002-11-14 | Noven Pharmaceuticals, Inc. | Patch applicator |
| WO2005018517A1 (en) * | 2003-08-15 | 2005-03-03 | Mylan Technologies, Inc. | Transdermal patch incorporating active agent migration barrier layer |
| CN102573722A (en) * | 2009-10-14 | 2012-07-11 | 久光制药株式会社 | A preparation method of adhesive patch and a device thereof |
| CN102573721A (en) * | 2009-09-30 | 2012-07-11 | 莫恩里克保健公司 | A method of attaching grip tabs to the carrier layer of a film dressing |
| CN103079506A (en) * | 2010-08-31 | 2013-05-01 | 日绊株式会社 | Adhesive sheet, use thereof, and method of adhering the adhesive sheet |
-
2014
- 2014-06-18 CN CN201410273505.5A patent/CN105287440A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6129929A (en) * | 1998-10-30 | 2000-10-10 | Noven Pharmaceuticals, Inc. | Patch applicator |
| WO2002089717A1 (en) * | 1999-08-03 | 2002-11-14 | Noven Pharmaceuticals, Inc. | Patch applicator |
| WO2005018517A1 (en) * | 2003-08-15 | 2005-03-03 | Mylan Technologies, Inc. | Transdermal patch incorporating active agent migration barrier layer |
| CN102573721A (en) * | 2009-09-30 | 2012-07-11 | 莫恩里克保健公司 | A method of attaching grip tabs to the carrier layer of a film dressing |
| CN102573722A (en) * | 2009-10-14 | 2012-07-11 | 久光制药株式会社 | A preparation method of adhesive patch and a device thereof |
| CN103079506A (en) * | 2010-08-31 | 2013-05-01 | 日绊株式会社 | Adhesive sheet, use thereof, and method of adhering the adhesive sheet |
Non-Patent Citations (1)
| Title |
|---|
| 黎迎等: "压敏胶应用于中药贴剂研究进展", 《中国中医药信息杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4540688B2 (en) | Fastening means for a wearable pharmaceutical injector used by being fastened to a living body | |
| ES2739469T3 (en) | Preparation of adhesive tape | |
| BRPI0411032A (en) | hydrophilic adhesive composition, medical article, method for manufacturing the adhesive composition, and transdermal delivery device | |
| DK166193B (en) | Plaster with active substance for controlled administration of active substances to the skin | |
| JP2010163367A (en) | Patch and patch preparation | |
| TWM329426U (en) | Pharmacy patch | |
| TWM508308U (en) | Improved structure of infiltration type thin film patch | |
| CN105287440A (en) | Permeation type pharmaceutic thin film patch | |
| US11071717B2 (en) | Anesthetic bandage | |
| TW201545776A (en) | Infiltration type medical thin film patch | |
| CN202605425U (en) | Indwelling needle fixed adhesive tape | |
| CN212651206U (en) | Disposable children's oral mucosa surface anesthesia safety is applied ointment or plaster | |
| CN111359073A (en) | Disposable children's oral mucosa surface anesthesia safety is applied ointment or plaster | |
| CN201912324U (en) | Novel acupuncture point administrating patch | |
| US8865209B1 (en) | Combined sublingual and gastro-intestinal delivery method of a liquid medication in a single volume limited dose | |
| CN103505795B (en) | Combined type functional fixing device (paste/piece/film) for indwelling needle or indwelling tube | |
| CN206120944U (en) | Improvement structure of film paster | |
| CN205251837U (en) | Film dressing | |
| CN213157935U (en) | Medicament paster of easy separation | |
| CN205964620U (en) | Disposable infusion pastes | |
| CN204840344U (en) | Navel subsides for internal medicine | |
| CN1921829B (en) | Patch | |
| CN205885641U (en) | Medicine applying plaster of additive topical application of drug | |
| CN213312403U (en) | Medical transfusion three way connection's fixed paster | |
| CN106860434A (en) | Increase viscous force, reduce excessive new traditional patch |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160203 |
|
| WD01 | Invention patent application deemed withdrawn after publication |