CN105287212A - Preparation process for improving stability of cream preparation - Google Patents
Preparation process for improving stability of cream preparation Download PDFInfo
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- CN105287212A CN105287212A CN201410313348.6A CN201410313348A CN105287212A CN 105287212 A CN105287212 A CN 105287212A CN 201410313348 A CN201410313348 A CN 201410313348A CN 105287212 A CN105287212 A CN 105287212A
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Abstract
The invention relates to cream preparation processes, in particular to a preparation process for improving the stability of a cream preparation, comprising following steps: a), adding materials into a container except for an emulsifier, raising the temperature to 70-85 DEG C, and stirring them for 0.5-1.5 h to fully dissolve them; b), then adding the emulsifier into the this container, during this process controlling the temperature to be 70-85 DEG C, and performing stirring for 0.5-1 h; stopping heating, and then lowering the temperature while stirring for 1-5 h so as to obtain a cream when the temperature is lowered to room temperature; c), performing filling on the finished cream obtained in step b, according to specifications. The smaller the base granules of the cream obtained by using the preparation method, the more stable the cream is; equipment investment is saved, and only one reaction tank is required in the preparation process while a separate phase preparation method requires at least two reaction tanks; the preparation is simple, operating is simple and convenient, energy is saved, and a production cycle is short.
Description
Technical field
The present invention relates to emulsifiable paste preparation technology, be specifically related to a kind of preparation technology increasing cream preparation stability.
Background technology
In the actual production of cream preparation, the existing method generally adopted has following several, namely phase-splitting preparation method, be mixed with method, mixed grinding preparation method (mostly be Preparation Room in Hospital small lot batch manufacture with) etc.Pharmaceutical producing enterprise many employings phase-splitting preparation method, it has many shortcomings, as aqueous phase and oil phase need be distinguished, need consider that the order of two-phase mixtures and the difference of temperature and emulsifying agent and principal agent add biphase selection, the quality of emulsifiable paste and stability need to improve, and equipment investment is comparatively large, and utilization rate of equipment and installations is low etc., bring many difficulties being difficult to overcome to industry preparation, have totally unfavorable impact storage period to the quality of product, product simultaneously.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of preparation technology increasing cream preparation stability.
Technical problem to be solved by this invention is achieved by the following technical programs:
Increase a preparation technology for cream preparation stability, comprise following steps:
A) raw material except emulsifying agent is added in a container, is heated to 70 ~ 85 DEG C of stirring 0.5 ~ 1.5h and raw material is dissolved completely;
B) be then added in said vesse by emulsifying agent, control temperature is 70 ~ 85 DEG C in this process, and stirs 0.5 ~ 1h; Stop heating, then lower the temperature while stirring, stir 1 ~ 5h and be down to room temperature, obtain emulsifiable paste;
C) the finished product emulsifiable paste that step b is obtained is carried out fill according to specification.
Further, mixing speed when stirring in step a is 100 ~ 250r/min.
Further, mixing speed when stirring in step b is 50 ~ 100r/min.
The present invention has following beneficial effect:
1. the emulsifiable paste matrix microgranule that obtains of this preparation method is less, and mastic is more stable;
2. save equipment investment, preparation process only needs a retort, and phase-splitting preparation method at least needs two retort;
3. preparation is simple, easy and simple to handle, and energy savings is with short production cycle.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be described in detail, and embodiment is only the preferred embodiment of the present invention, is not limitation of the invention.
Embodiment 1
Increase a preparation technology for cream preparation stability, comprise following steps:
A) raw material except emulsifying agent is added in a container, is heated to 80 DEG C of stirring 1h and raw material is dissolved completely; Mixing speed is 120r/min;
B) be then added in said vesse by emulsifying agent, control temperature is 80 DEG C in this process, and stirs 1h; Stop heating, then lower the temperature while stirring, stir 1h and be down to room temperature, obtain emulsifiable paste; Mixing speed is 80r/min;
C) the finished product emulsifiable paste that step b is obtained is carried out fill according to specification.
The emulsifiable paste matrix microgranule of this preparation method gained is less, mastic is more stable, after emulsifying agent addition emulsifying cause by thermal agitation in coarse dispersion system profit phase-contact surface the most greatly after emulsifying agent further dispersion make emulsifying agent fully be distributed in oil-water interfaces to produce the finest and the smoothest emulsifying effectiveness, the microgranule forming mastic is less.And namely the emulsifying agent phase-splitting addition method of prior art carries out in the moment emulsifying of two-phase mixtures, now profit contacts and insufficient, therefore the emulsifying agent participating in emulsifying is relatively less, emulsifying effectiveness is not good, emulsion droplet microgranule is larger, and the emulsifying agent of some is free in foreign minister, add the viscosity of emulsification system, so have impact on the release ability of obtained mastic.
Embodiment 2
Increase a preparation technology for cream preparation stability, comprise following steps:
A) raw material except emulsifying agent is added in a container, is heated to 75 DEG C of stirring 1.5h and raw material is dissolved completely; Mixing speed is 200r/min;
B) be then added in said vesse by emulsifying agent, control temperature is 75 DEG C in this process, and stirs 1h; Stop heating, then lower the temperature while stirring, stir 2h and be down to room temperature, obtain emulsifiable paste; Mixing speed is 100r/min;
C) the finished product emulsifiable paste that step b is obtained is carried out fill according to specification.
Embodiment 3
Increase a preparation technology for cream preparation stability, comprise following steps:
A) raw material except emulsifying agent is added in a container, is heated to 70 DEG C of stirring 1h and raw material is dissolved completely; Mixing speed is 150r/min;
B) be then added in said vesse by emulsifying agent, control temperature is 70 DEG C in this process, and stirs 1h; Stop heating, then lower the temperature while stirring, stir 5h and be down to room temperature, obtain emulsifiable paste; Mixing speed is 100r/min;
C) the finished product emulsifiable paste that step b is obtained is carried out fill according to specification.
The above embodiment only have expressed embodiments of the present invention; it describes comparatively concrete and detailed; but therefore can not be interpreted as the restriction to the scope of the claims of the present invention; in every case the technical scheme adopting the form of equivalent replacement or equivalent transformation to obtain, all should drop within protection scope of the present invention.
Claims (3)
1. increase a preparation technology for cream preparation stability, it is characterized in that comprising following steps:
A) raw material except emulsifying agent is added in a container, is heated to 70 ~ 85 DEG C of stirring 0.5 ~ 1.5h and raw material is dissolved completely;
B) be then added in said vesse by emulsifying agent, control temperature is 70 ~ 85 DEG C in this process, and stirs 0.5 ~ 1h; Stop heating, then lower the temperature while stirring, stir 1 ~ 5h and be down to room temperature, obtain emulsifiable paste;
C) the finished product emulsifiable paste that step b is obtained is carried out fill according to specification.
2. a kind of preparation technology increasing cream preparation stability according to claim 1, is characterized in that: mixing speed when stirring in step a is 100 ~ 250r/min.
3. a kind of preparation technology increasing cream preparation stability according to claim 1, is characterized in that: mixing speed when stirring in step b is 50 ~ 100r/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410313348.6A CN105287212A (en) | 2014-07-03 | 2014-07-03 | Preparation process for improving stability of cream preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410313348.6A CN105287212A (en) | 2014-07-03 | 2014-07-03 | Preparation process for improving stability of cream preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105287212A true CN105287212A (en) | 2016-02-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410313348.6A Withdrawn CN105287212A (en) | 2014-07-03 | 2014-07-03 | Preparation process for improving stability of cream preparation |
Country Status (1)
| Country | Link |
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| CN (1) | CN105287212A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108210449A (en) * | 2018-02-02 | 2018-06-29 | 佛山市南海东方澳龙制药有限公司 | Dog Terbinafine hydrochloride emulsifiable paste and preparation method thereof |
-
2014
- 2014-07-03 CN CN201410313348.6A patent/CN105287212A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108210449A (en) * | 2018-02-02 | 2018-06-29 | 佛山市南海东方澳龙制药有限公司 | Dog Terbinafine hydrochloride emulsifiable paste and preparation method thereof |
| CN108210449B (en) * | 2018-02-02 | 2021-01-26 | 佛山市南海东方澳龙制药有限公司 | Terbinafine hydrochloride cream for dogs and preparation method thereof |
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| C06 | Publication | ||
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| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160203 |